抽象
虽然在慢性支气管炎患者的整个呼吸道中发现炎症变化,但慢性支气管炎发病机制仍然不清楚。本研究的目的是调查患有患者的气道炎症,而不会加剧支气管炎。研究了十三个慢性支气管患者和九个正常受试者。在基线条件(B)下,在致支气管炎(E)的加剧期间,研究了八个患者。进行了细胞学分析的支气管镜和支气管肺泡灌洗(BAL),并通过固相酶免疫测定在血清和BAL上清液中测定粒细胞/巨噬细胞凝聚因子(GM-CSF)的水平。与基线条件下的患者相比,加剧的慢性支气管内患者具有增加的BAL中性粒细胞(10 +/- 3和83 +/- 18x10(3)细胞x ml(-1))。P <0.0001)和BAL嗜酸性粒细胞(1.9 +/- 0.5和6.7 / -1.9x10(3)细胞x ml(-1); p = 0.014)。与整体慢性支气管炎的患者相比,与对照受试者(36 +/- 5和19 +/- 4 pg x ml(-1)相比,Bal GM-CSF水平显着增加; P = 0.035),和类似水平的血清GM-CSF。与基线条件下的患者(1.4 +/- 0.4和13 +/- 1pg x ml(-1)相比,慢性支气管内患者血清GM-CSF水平显着增加。。 BAL levels of GM-CSF were also increased in chronic bronchitic patients with an exacerbation (25+/-5 and 54+/-8 pg x mL(-1), respectively; p=0.009). During exacerbations of chronic bronchitis there are changes in the cell populations in bronchoalveolar lavage of patients consistent with a recruitment of polymorphonuclear leucocytes in the airway lumen. The increased levels of granulocyte/macrophage colony-stimulating factor might suggest a role for this cytokine in the inflammatory processes of chronic bronchitis.