摘要
使用都保等干粉吸入器给病人的药物运送据信受到所使用的吸气流量的影响。临床研究表明,这种给药系统可以有效地用于儿童。然而,目前尚不清楚气道的总剂量和重量校正剂量如何随年龄变化。使用锝-99m (99mTc)标记的布地奈德进行沉积研究,以确定年龄对分娩的影响。招募了21名4-16岁的囊性纤维化患儿。临床表现稳定,肺功能正常。最初,在一个包含37 MBq的99mTc的洪水源前进行了伽马相机扫描。随后,受试者通过一个低阻力吸气过滤器吸入,该过滤器连接到一个商用的都保。随后,他们立即吸入一种非商业性的含有布地奈德标记为99mTc的都保,然后进行前后伽玛相机扫描。两个吸入器都与便携式肺活量计相连,记录每次吸入时通过都保吸入器的吸气流量峰值。 The total body dose was calculated from the dose deposited on the inspiratory filter connected to the commercial Turbuhaler. Analysis of the gamma camera images provided information on the proportion of the radiolabel delivered to the lungs compared to that deposited in the upper airway and stomach. As expected, a highly significant positive correlation was noted between the peak inspiratory flow generated by the patient through the Turbuhaler and the dose delivered to the lung. Similarly, there was a highly significant positive correlation between age and "total lung dose". However, when total lung dose was corrected for body weight, there was a nonsignificant negative correlation with age. This study suggests that the "weight-corrected lung dose" achieved when children aged > 6 yrs use the Turbuhaler, is largely independent of age. It would appear that the flow-dependent properties of this device are such that the reduced peak inspiratory flow generated by younger children results in a lower dose to the lungs, but that this is off-set by their lower body weight. This is unlikely to be a property of other devices with different flow/drug delivery characteristics.