抽象的
在不同的人类恶性肿瘤中,包括肺癌,生活质量(QOL)影响患者的临床结果。然而,许多QOL尺寸受到物理状态的影响。目前的研究是为了描绘抑郁症的作用,一种不一定受体因素影响的心态。所有患者都观察到肺部的新诊断癌,接受了W.W.K.提出的自评抑郁尺度(SDS)的副本。Zung。一百三十三名患者能够愿意完成调查问卷。根据最初描述的,计算了凹陷指数。19世纪其他预后的重要变量被记录并获得评估。在进行调查问卷中包含的所有20个项目的95名患者中,53名具有SDS指数<或= 50(无抑郁症),而42则受到适度或严重抑制(SDS指数> 50)。抑郁症患者的存活率显着降低(P = 0.048)。 Diverse SDS subscales were associated with survival, in either univariate or multivariate analysis. SDS item 19, "I feel that others would be better off if I were dead", emerged as the most significant one. A multivariate model of survival, constructed using only SDS data, had a global Chi-squared value of 29.78, and a p-value of 0.00023. Based on this evidence, it appears that a relationship does exist between patients' depression and prognosis, at least in lung cancer. Further studies are needed to clarify the prognostic effect of depression in more specific (and homogeneous) subgroups of patients.