摘要
本研究的目的是综合评估日本阻塞性睡眠呼吸暂停(OSA)患者的头影测量特征,并阐明头影测量变量与呼吸暂停严重程度之间的关系。48人头测量法的测量变量在37岁的健康男性和114年男性阻塞性睡眠呼吸暂停综合症的病人,他们被分类到54个非肥胖(体重指数(BMI) < 27公斤x m (2), apnoea-hypopnoea指数(AHI) = 25.3 + / - -16.1事件x h(1))和60肥胖(体重指数>或= 27公斤x m (2), AHI = 45.6 + / - -28.0 h(1))事件组。对所有OSA患者和19名正常对照组进行了诊断性多导睡眠描画。与bmi匹配的正常对照组相比,非肥胖OSA患者表现出若干头影测量缺陷:1)颅底、上颌骨水平面的A-P距离减小,骨咽宽度减小;2)舌头扩大,舌量下移;3)软腭扩大;4)舌骨位置较低;5) 4个不同水平上气道宽度减小。肥胖OSA组软组织异常更广泛、严重,颅面骨性结构有少量缺陷。对于非肥胖OSA组,以两个骨结构变量:前颅底长度(S-N)和下颌长度(Me-Go)为决定因素,逐步回归模型对AHI有显著影响。 Although the regression model retained only linear distance between anterior vertebra and hyoid bone (H-VL) as an explainable determinant for AHI in the obese OSA group, H-VL was significantly correlated with soft tissue measurements such as overall tongue area (Ton), inferior tongue area (Ton2) and pharyngeal airway length (PNS-V). In conclusion, Japanese obstructive sleep apnoea patients have a series of cephalometric abnormalities similar to those described in Caucasian patients, and that the aetiology of obstructive sleep apnoea in obese patients may be different from that in non-obese patients. In obese patients, upper airway soft tissue enlargement may play a more important role in the development of obstructive sleep apnoea, whereas in non-obese patients, bony structure discrepancies may be the dominant contributing factors for obstructive sleep apnoea.