抽象的
一氧化氮在气道功能的调节中具有重要作用,并且可以具有促炎作用。支气管高反应性(BHR)和呼吸系统症状是Sjogren综合征(SS)的患者常见的。本研究的目的是确定SS的患者是否具有增加的呼出量,也没有与呼吸系统症状和BHR相关。在18例SS和13名正常受试者中测量呼出的NO,在三种不同的场合使用化学发光方法的间隔至少3天。通过甲胆碱挑衅评估气道反应性。测定血清髓过氧化物酶(MPO),人嗜嗜中性粒细胞脂素(HNL),嗜酸性粒细胞阳离子蛋白(ECP)和嗜酸性粒细胞过氧化物酶(EPO)。SS的患者呼出不显着高于对照(147 +/- 82对88 +/- 52 NL X min(-1);平均+/- SD; P = 0.041)。呼出不与年龄相关(部分r = 0.52,p = 0.006)和血清HNL(部分r = 0.46,p = 0.014)。呼出的NO和呼吸症状,BHR或血清MPO,ECP或EPO之间没有显着相关性。疾病持续时间与血清MPO(R = -0.47,P = 0.043)负相关。 In patients with SS, a positive correlation was found between symptom score and serum ECP (partial r=0.65, p=0.003) and EPO (partial r=0.62, p=0.004) and a negative correlation with age (partial r=-0.60, p=0.005). In conclusion, elevated levels of exhaled nitric oxide in patients with Sjogren's syndrome were demonstrated. The mechanism underlying this increase in exhaled nitric oxide in Sjogren's syndrome is not known.