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[(,)-334.6(M)0(.)-334.5(Rotger)]TJ
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[(,)-334.6(J.A.)-330.9(Barbera)]TJ
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(\302)Tj
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({)Tj
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[(,)-334.6(D)0(.)-330.5(Navajas)]TJ
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[(in)-463(COPD)-461.7(patients.)-462.2(R.)-454.8(Farr)27.8(e)]TJ
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(\302)Tj
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[(,)-458.2(R)0(.)-461.1(Peslin,)-464.3(M.)-458.1(Rotger)103.7(,)-458.2(J.A.)-463.3(Barbera)]TJ
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(\302)Tj
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[(,)-458.2(D)0(.)-460.9(Navajas.)]TJ
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(#)Tj
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(ERS)Tj
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[(Journals)-335.6(Ltd)-334.6(1999.)]TJ
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T*
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(R)Tj
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(rs)Tj
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(R)Tj
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(L,sb)Tj
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[(\))-316.6(i)0(n)-316.1(patients)-320.8(with)-319.3(airway)]TJ
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T*
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(R)Tj
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(rs)Tj
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(R)Tj
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(L,sb)Tj
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(P)Tj
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(tp)Tj
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(\))Tj
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(R)Tj
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(rs)Tj
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[(over)-345.3(the)-339.2(same)-347.1(periods.)-347.4("Instan-)]TJ
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(R)Tj
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(L,sb)Tj
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[(wer)11.3(e)-271.2(also)-267.1(obtained)-273(by)-263.1(computing)-272.9(the)-269.7(dynamic)-268.1(component)-270.3(of)]TJ
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(P)Tj
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(tp)Tj
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[(,)-338(and)-330.8(compar)10.8(ed)-332.5(to)-335.1(simultaneous)-339.4(values)-334(of)]TJ
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(rs)Tj
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(and)Tj
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(L,sb)Tj
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(L,sb)Tj
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(-1)Tj
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[(at)-335.1(16)-334.1(Hz.)]TJ
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(L,sb)Tj
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T*
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[(*Lab.)-419(Biofisica)-412(i)-427.1(Bioenginye)13.6(ria,)-421(Facultat)]TJ
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(')Tj
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(me)Tj
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[(diques)-502.1(Agust)]TJ
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(\302)Tj
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[(Pi)-501(Sunyer)-503.6(\(IDIBA)9.5(PS\),)]TJ
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[(Universitat)-30.9(de)-30.4(Barcelona,)-25.9(Spain.)]TJ
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(+)Tj
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(Unite)Tj
1.821 0.0427 TD
(\302)Tj
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[(14)-31.4(de)]TJ
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[(Nancy)67(,)-354.6(France.)]TJ
/F4 1 Tf
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({)Tj
/F3 1 Tf
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[(Servei)-355.6(de)-357.6(Pneumolog)12.4(ia)-360(i)]TJ
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(Al)Tj
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(.)Tj
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(le)Tj
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(\301)Tj
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[(rgia)-825.4(Respirato)]TJ
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(\301)Tj
0.4054 -0.0427 TD
[(ria,)-833.5(Hospital)-839.5(Clinic)]TJ
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[(Provincia)11.1(l,)-539.8(Institut)-527.6(d)]TJ
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(')Tj
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[(lnvestigacio)10.4(ns)-537.6(Bio-)]TJ
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(me)Tj
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(\301)Tj
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[(diques)-445.2(August)-441.6(Pi)-444.1(Sunyer)-446.7(\(IDIBA)9.5(PS\),)]TJ
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[(Barcelona,)-324.7(Spain.)]TJ
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[(Corresponde)11.8(nce:)-255.1(R.)-250.5(Farre)]TJ
9.8161 0.0427 TD
(\302)Tj
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[(,)-255(Lab.)-250.4(Biofisica)-255.5(i)]TJ
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[(Bioenginye)13.6(ria,)-961.6(Facultat)-959.6(de)-955.1(Medicina,)]TJ
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[(Casanova)-1173.9(143,)-1173.4(E-08036)-1176(Barcelona,)]TJ
0 -1.0599 TD
[(Spain.)-329(Fax:)-325.1(34)-330.1(934024516)]TJ
0 -2.1268 TD
[(Keywords)11.5(:)-270.6(Cyclic)-258(variations)-262.9(of)-266.3(resistance)10.6(,)]TJ
0 -1.0599 TD
[(frequency)-163.3(dependence)-158.8(of)-173.8(resistance)10.6(,)-347.5(resist-)]TJ
T*
[(ance)-145(measurem)10.8(ents,)-142.5(respiratory)-144.9(mechanic)11.1(s,)]TJ
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[(upper)-330.1(airway)-324.7(artefact)]TJ
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[(Received:)-327.9(July)-329.5(14)-330.1(1998)]TJ
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[(Accepted)-304.1(after)-310.3(revision)-308.4(February)-306.5(15)-308.8(1999)]TJ
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[(This)-367.8(work)-364.2(was)-366.3(supported,)-359.8(in)-361(part,)-369.1(by)-365.7(the)]TJ
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(Comisio)Tj
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(\302)Tj
0.4054 -0.0427 TD
[(n)-609.6(Interministeria)6.4(l)-619.1(d)0(e)-613.6(Ciencia)-610.6(y)]TJ
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[(T)63.4(ecnolog)42.8(\302)]TJ
3.6775 0 TD
[(a)-388.1(\(CICYT)75.9(,)-390.2(SAF96-007)13.6(6\),)-386.2(DGE-)]TJ
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[(SIC/)-331(PM99-0027)14.8(,)-333.3(and)-327(by)-330.1(PM980027.)]TJ
9.963 0 0 9.963 68.258 371.849 Tm
[(Be)16.1(ca)14.7(us)20(e)-530.4(i)0(t)-524.1(i)0(s)-522.9(s)0(t)17.7(r)0(i)17.3(c)0(t)18.5(l)0(y)-527.4(n)0(o)21.2(n)0(i)18.9(n)0(v)15.5(a)0(s)19.6(i)0(v)13.2(e)-530.4(an)20.8(d)-535.7(o)0(n)21.2(l)0(y)-527.4(r)0(e)19.2(q)0(u)21.2(i)0(r)11.6(e)0(s)]TJ
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[(pa)15.1(ss)18.9(iv)18.9(e)-302.8(c)0(o)20.8(o)0(p)15.5(e)0(r)19.2(a)0(t)18.4(i)0(o)13.2(n)-296.7(fr)18(om)-294.9(th)18.9(e)-302.8(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(,)-293.7(t)0(h)18.9(e)-297.1(me)12(as)19.6(ur)19.6(em)12(en)20.8(t)-304.7(o)0(f)]TJ
T*
[(to)18.9(ta)18.4(l)-424.2(r)0(e)19.2(s)0(p)14.4(i)13.9(ra)13.5(to)18.9(ry)-412.8(re)19.2(si)17.7(st)17.7(an)15.1(ce)-412.1(\()]TJ
/F5 1 Tf
11.2673 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 176.485 350.419 Tm
-0.0161 Tc
(rs)Tj
9.963 0 0 9.963 181.928 350.419 Tm
0 Tc
[(\))-423.5(b)0(y)-411.3(m)13.2(ea)14.7(ns)-412.4(of)-412.8(th)18.9(e)-422.3(f)0(o)19.6(r)0(c)19.2(e)0(d)]TJ
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[(os)20(ci)12.8(ll)22.2(at)12.8(io)18.9(n)-461.7(t)0(e)12.8(c)0(h)20.8(n)0(i)18.9(q)0(u)15.5(e)-462.1(\(F)14.7(OT)18.9(\))-469([)0(1)19.6(])-474.7(is)-477.4(increasing)-10.7(ly)-476.2(used)-477(to)]TJ
T*
[(asses)-8.2(s)-485.7(airway)-491.3(obstr)-9(uction)-493.4(in)-487.6(patients.)-493.6(In)-486.8(contr)-8.2(ast)-490(with)]TJ
0 -1.0698 TD
[(forced)-230.5(expiratio)-10.7(n)-222.7(manoe)-7.8(uvres)-223.2([2],)-227.8(the)-227(FOT)-225.8(does)-220.9(not)-226.6(mod-)]TJ
0 -1.0755 TD
[(ify)-359.1(broncho)-7.3(mot)-7.8(or)-355.9(tone)-358.7([3],)-358.7(whi)-8.6(ch)-354.7(makes)-361.8(it)-359.1(a)-359.7(method)-363.3(of)]TJ
T*
[(choice)-378.1(for)-375.4(study)-7.4(ing)-368.9(bronchi)-9.7(al)-374.2(react)-9(ivity)57.3(.)-370.3(T)63.4(o)-370.7(avoid)-376.5(inte)-8.2(r-)]TJ
T*
[(ference)-442.6(from)-441.9(spont)-7.4(aneous)-444.7(breathing,)-446.9(the)-437.6(measurem)-10.7(ents)]TJ
T*
[(are)-368.9(pe)-7.6(rformed)-372.2(at)-374.2(frequen)-9.3(cies)-371.6(at)-368.5(least)-374.8(one)-366.9(order)-377.3(of)-367.3(mag-)]TJ
T*
[(nitude)-430.8(above)-431.4(norm)-7.8(al)-425.4(breat)-8.6(hing)-432.2(frequency)57(.)-427.2(This)-431.8(confer)-8.6(s)]TJ
T*
[(to)-373.8(the)-380.7(method)-380.4(a)-376.7(time)-381.2(resoluti)-10.7(on)-377.1(good)-372.9(eno)-8.4(ugh)-372.2(to)-379.5(follow)]TJ
T*
[(changes)-326.4(of)]TJ
/F5 1 Tf
4.6606 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 110.778 243.326 Tm
(rs)Tj
9.963 0 0 9.963 119.509 243.326 Tm
[(throu)-7.8(gh)-320.2(the)-318.1(respirato)-11.1(ry)-321.8(cycle)-320.4([4\2616].)-320.4(Con)-7(-)]TJ
-6.1458 -1.0755 TD
[(versel)-10.6(y)61.8(,)-370.3(a)-371.1(potential)-381.4(drawback)-377(of)-373(the)-375(high)-375.3(frequenc)-10.5(ies)-370.5(is)]TJ
T*
(that)Tj
/F5 1 Tf
1.6389 0 TD
(R)Tj
/F3 1 Tf
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[(th)18.9(e)-280(h)0(e)20.8(a)0(d)-269.4(g)0(e)15.1(n)0(e)15.1(r)0(a)19.2(t)0(o)18.9(r)-281.2(te)18.4(ch)20.8(ni)13.2(qu)21.2(e)-280([)0(1)19.6(7)0(])-282(t)0(o)-288.4(minim)-9.2(ize)-290(transmur)-10.7(al)]TJ
0 -1.0527 TD
[(press)-8.2(ure)-328.7(variation)-10.7(s)-326.3(across)-333.7(the)-329.4(upper)-330.2(airway)-332(wal)-9(l)-327.5(and)-327.1(the)]TJ
0 -1.0471 TD
[(corres)-9.8(pondin)-7(g)-336.5(artef)-10.2(act)-341.2([16,)-345.7(17].)-345.7(The)-342.6(generat)-10.5(or)-338.9(consi)-7.8(sted)]TJ
0 -1.0528 TD
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0 -1.0471 TD
[(neck)-339.6(coll)-8.2(ar)-339.3(and)-338.4(connect)-8.9(ed)-337.7(to)-334(a)-342.6(100-W)-342.3(loudspeaker)42.1(.)-336.1(The)]TJ
0 -1.0528 TD
[(latter)-378.3(was)-377.7(supplied)-376.7(with)-375.9(a)-371.1(c)0(o)-7.6(mputer-generated)-379.7(2\26132)-372.9(Hz)]TJ
0 -1.0471 TD
[(pseudor)-8.5(andom)-331.7(signa)-7.8(l.)-327.9(The)-331.2(a)-6.9(pplied)-334.1(airway)-332(o)-6.5(pening)-331.7(pres-)]TJ
0 -1.0527 TD
[(sure)-347.7(\()]TJ
/F5 1 Tf
2.3161 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 87.364 489.543 Tm
(ao)Tj
9.963 0 0 9.963 94.847 489.543 Tm
[(\))-343.8(was)-343.6(meas)-8.2(ured)-346.5(using)-348.8(a)-342.6(trans)-9.4(ducer)-347.7(\(Ho)-7.8(neywell)]TJ
-3.6704 -1.0471 TD
[(176;)-398.1(Hone)-7.4(ywell)-399.9(Freeport,)-404.7(IL,)-394.6(USA\),)-399.1(and)-401(gas)-396.5(flow)-397.9(\(V)]TJ
/F10 1 Tf
22.2557 0 TD
(')Tj
/F3 1 Tf
0.2219 0 TD
(\))Tj
-22.4777 -1.0528 TD
[(using)-303.3(a)-302.8(Fleisch-II)-308.6(pneum)-7.4(atacho)-8.2(graph)-301.7(\(Sibel)-306.5(S.A.,)-301.7(Bar)-9(ce-)]TJ
0 -1.0471 TD
[(lona,)-757.4(Sp)-6.4(ain\))-758.6(connect)-8.9(ed)-753.1(to)-755.1(a)-758(differential)-758.7(transduc)-12.1(er)]TJ
0 -1.0527 TD
[(\(Hone)-9.7(ywell)-200.7(176\).)-204.2(In)-196.6(add)-8.4(ition,)-199.1(oesopha)-7.3(gea)-8.8(l)-196.6(press)-8.2(ure)-197.8(\()]TJ
/F5 1 Tf
20.816 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 271.672 447.704 Tm
(oes)Tj
9.963 0 0 9.963 282.217 447.704 Tm
(\))Tj
-22.4777 -1.0471 TD
[(was)-184.2(meas)-8.2(ured)-181.5(with)-182.5(a)-183.3(balloon)-186.9(\(4)-179.5(cm)-187.2(perimete)-11.1(r\))-181.1(filled)-184.4(with)-188.2(1)]TJ
0 -1.0528 TD
[(mL)-242.1(air)-240(and)-241.7(conne)-10.3(cted)-239.6(to)-242.9(a)-240.2(transducer)-248.9(\(Honeyw)-9.5(ell)-240.8(176P)-8(C/)]TJ
T*
[(14\))-555.9(throu)-7.8(gh)-553.5(a)-558.8(90-cm-lon)-10.3(g)-552.8(cathet)-10.6(er)-555.5(\(0.12)-557(c)-6.9(m)-555.9(internal)]TJ
0 -1.0471 TD
[(diame)-10.1(ter\).)-299.6(The)-297(posit)-9.8(ion)-294.9(of)-299(the)-301(balloon)-300.7(in)-299.8(the)-301(oesopha)-7.3(gus)]TJ
0 -1.0528 TD
[(was)-138.7(checked)]TJ
/F5 1 Tf
5.0646 0 TD
0.0069 Tc
[(vi)6.9(a)]TJ
/F3 1 Tf
1.3487 0 TD
0 Tc
[(the)-136(occlusion)-144.5(test)-134.6(of)-304.7(B)]TJ
6.974 0 0 6.974 207.609 395.376 Tm
0.0001 Tc
[(A)75.9(YDUR)]TJ
/F5 1 Tf
9.963 0 0 9.963 233.121 395.376 Tm
0 Tc
[(et)-135.2(al)]TJ
/F3 1 Tf
1.6161 0 TD
[(.)-131.3([19].)]TJ
/F5 1 Tf
2.4128 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 279.326 395.376 Tm
(tp)Tj
9.963 0 0 9.963 58.28 384.945 Tm
[(was)-343.6(obtained)-347.4(from)-339.4(the)-346.5(dif)10.8(ference)-345.9(b)-6.5(etween)]TJ
/F5 1 Tf
17.4188 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 237.883 384.945 Tm
(ao)Tj
9.963 0 0 9.963 248.655 384.945 Tm
(and)Tj
/F5 1 Tf
1.7811 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 272.409 384.945 Tm
(oes)Tj
9.963 0 0 9.963 282.954 384.945 Tm
(.)Tj
-22.5516 -1.0527 TD
[(After)-366.5(low-pas)-9.1(s)-360.5(filteri)-12.8(ng)-360(at)-362.8(32)-360(Hz)-364.4(to)-362.4(avoid)-365.1(aliasing,)]TJ
/F5 1 Tf
21.1973 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 275.471 374.457 Tm
(ao)Tj
9.963 0 0 9.963 282.954 374.457 Tm
(,)Tj
/F5 1 Tf
-22.5516 -1.0471 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 64.29 364.025 Tm
(oes)Tj
9.963 0 0 9.963 76.876 364.025 Tm
(and)Tj
/F5 1 Tf
1.6389 0 TD
(V)Tj
/F10 1 Tf
0.6089 0 TD
(')Tj
/F3 1 Tf
0.4211 0 TD
[(wer)-8.2(e)-200.3(samp)-7.8(led)-204.2(a)-6.9(t)-202.3(a)-206(rate)-207(of)-208(128)-207.2(Hz)-205(for)-204.6(p)-6.5(eriods)-209.3(of)]TJ
-4.5354 -1.0527 TD
[(32)-177.9(s)-178.4(using)-183.8(a)-177.6(person)-7.8(al)-180.7(compu)-7.4(ter)-177.4(syst)-7.8(em)-181.5(equipped)-185.7(with)-182.5(a)-177.6(12-)]TJ
0 -1.0471 TD
[(bit)-445.2(analogu)-8.5(e\261digital)-449.7(interface.)-449.3(Eight)-445.2(such)-442.8(record)-8.6(s)-440.1(wer)-8.2(e)]TJ
0 -1.0527 TD
[(collec)-10.6(ted)-335.1(in)-334(each)-340(patient)-337.6(over)-340.8(a)-331.2(perio)-8.2(d)-336.5(o)0(f)-333.2(1)0(0)-337.3(min.)]TJ
/F5 1 Tf
0 -2.3786 TD
[(Data)-339.4(analys)-8.6(is)]TJ
0 -1.8551 TD
[(T)91.1(o)0(t)18.9(a)0(l)-334(r)43.6(es)13.9(pi)18.9(ra)20(to)13.2(ry)-333.2(r)43.6(e)0(s)13.9(i)0(s)17.7(t)0(a)18.9(n)0(c)20.8(e)-342.6(me)16.9(as)14.4(ur)48.5(em)16.9(en)20.8(t)]TJ
/F3 1 Tf
16.3888 0 TD
[(.)-341.8(A)0(m)14.2(o)0(n)21.2(g)-342.2(th)18.9(e)-342.6(1)0(6)]TJ
-16.3888 -1.0471 TD
[(fr)18(eq)15.1(ue)20.8(nc)15.1(y)-530(c)0(o)15.1(m)0(p)18.1(o)0(n)21.2(e)0(n)15.1(t)0(s)-522.9(i)0(n)-521.8(t)0(h)18.9(e)-536.1(fo)19.6(rc)19.2(ed)-525.5(os)20(ci)18.4(ll)16.5(at)18.4(io)13.2(n)-530(s)0(i)17.7(g)0(n)21.2(a)0(l)12.8(,)]TJ
0 -1.0527 TD
[(so)20(me)-289.6(ha)20.8(d)-296.7(a)0(n)-280.8(i)0(n)13.2(t)13.9(eg)15.1(er)-288.1(nu)21.2(mb)18.1(er)-288.1(of)-282(da)15.1(ta)-283.2(po)15.5(in)18.9(ts)-283.9(pe)15.1(r)-292.6(o)0(s)20(c)0(i)18.4(l)0(l)16.5(a)0(t)18.4(i)0(o)13.2(n)]TJ
25.1977 50.4012 TD
[(cy)15.1(cl)18.4(e)-234.5(\()0(6)19.6(4)-228.4(po)15.5(in)18.8(ts)-221.3(at)-226.2(2)-228.4(H)0(z)16.9(,)-233.7(32)-217.8(at)-226.2(4)-228.4(H)0(z)16.9(,)-233.7(16)-217.8(at)-226.2(8)-228.4(H)0(z)16.9(,)-233.7(ei)18.4(gh)21.2(t)-230.8(a)0(t)-226.2(1)0(6)]TJ
0 -1.0527 TD
[(Hz)-284.7(an)15.1(d)-291(f)0(o)19.6(u)0(r)-282(a)0(t)-283.1(3)0(2)-286.1(H)12.4(z\))13.5(.)-290.6(T)12.2(hi)13.2(s)-286.5(p)0(e)15.1(r)0(m)16.5(i)0(t)16.5(t)0(e)18.5(d)-291(th)18.9(e)-291.4(c)0(o)15.1(m)0(p)18.1(u)0(t)18.9(a)0(t)12.8(i)0(o)18.9(n)-291(of)]TJ
/F5 1 Tf
T*
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 315.269 750.671 Tm
(rs)Tj
9.963 0 0 9.963 324.964 750.671 Tm
[(on)-405.6(a)-416.6(c)0(y)15.1(c)0(l)18.5(e)0(-)19.2(b)0(y)15.5(-)0(c)19.2(y)0(c)15.1(l)0(e)-408.3(b)0(a)20.8(s)0(i)17.7(s)-417.4(an)20.8(d)-416.2(t)0(h)13.2(e)-410.9(ob)15.5(te)18.4(nt)18.9(io)13.2(n,)-405.2(fo)19.6(r)-417.8(t)0(h)18.9(e)]TJ
-1.5706 -1.0584 TD
[(hi)13.2(gh)21.2(es)14(t)-293.4(f)0(r)12.4(e)0(q)20.8(u)0(e)15.1(n)0(c)20.8(i)0(e)12.8(s)0(,)-286.9(o)0(f)-287.7(a)-302.8(m)13.2(u)0(c)15.1(h)-296.7(be)15.1(tt)16.5(er)-288.1(ti)16.5(me)-289.6(re)13.5(so)20(lu)18.8(ti)16.5(on)-291.8(t)13.9(h)0(a)15.1(n)]TJ
0 -1.0527 TD
[(th)13.2(e)-382.4(b)0(a)15.1(s)0(i)17.7(c)-382.4(re)13.5(pe)20.8(ti)16.5(ti)16.5(on)-377.1(fr)18(eq)15.1(ue)20.8(nc)15.1(y)-382(o)0(f)-378.7(t)0(h)18.9(e)-388.1(ex)15.1(ci)18.5(ta)18.4(ti)16.5(on)-377.1(si)17.7(gn)21.2(al)-379.9(\(2)]TJ
T*
[(Hz)16.9(\).)-270.2(Am)19.8(on)15.5(g)-273.9(t)0(h)18.9(e)0(s)13.9(e)-274.3(fr)18(eq)15.1(ue)20.8(nc)15.1(ie)18.4(s,)-264.1(8)-273.9(a)0(n)15.1(d)-273.9(16)-263.3(Hz)-267.6(we)16.9(re)-271(fo)19.6(cu)15.1(se)19.6(d)]TJ
0 -1.0584 TD
[(up)15.5(on)15.5(,)-353.2(s)0(i)17.7(n)0(c)20.8(e)-354(th)13.2(ey)-343.4(co)15.1(mb)18.1(in)18.9(ed)-349.1(a)-354(g)0(o)21.2(o)0(d)-348.6(t)0(i)16.5(m)0(e)-346.5(r)0(e)19.2(s)0(o)14.4(l)0(u)18.9(t)0(i)16.5(o)0(n)-343(a)0(n)15.1(d)-353.6(a)]TJ
0 -1.0527 TD
[(la)12.8(r)20.4(g)0(e)-519.8(n)0(u)15.5(m)0(b)18.1(e)0(r)-521.4(o)0(f)-526.7(d)0(a)20.8(t)0(a)-522.2(p)0(o)15.5(i)0(n)18.8(t)0(s)-522.9(p)0(e)20.8(r)-531.6(cy)15.1(cl)18.5(e.)-519.4(Th)17.1(e)-530.4(f)0(o)14(l)0(l)16.5(o)0(w)17.3(i)0(n)18.8(g)]TJ
T*
[(an)15.1(al)18.4(ys)14.3(i)13.9(s)-246.7(wa)16.9(s)-246.7(m)0(a)17.7(d)0(e)-240.9(a)0(t)-231.9(e)0(a)14.7(c)0(h)-235.2(o)0(f)-236.4(t)0(h)18.9(e)0(s)13.9(e)-245.9(fr)18(eq)15.1(ue)20.8(nc)15.1(ie)18.5(s:)]TJ
/F5 1 Tf
18.7447 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 501.959 687.628 Tm
(ao)Tj
9.963 0 0 9.963 511.767 687.628 Tm
[(an)15.1(d)]TJ
/F5 1 Tf
1.6673 0 TD
(V)Tj
/F10 1 Tf
0.5975 0 TD
(')Tj
/F3 1 Tf
-22.5858 -1.0584 TD
[(we)16.9(re)-430.3(fi)17.3(rs)18.4(t)-435.6(p)0(a)20.8(s)0(s)18.8(e)0(d)-428.7(t)0(h)18.9(r)0(o)19.6(u)0(g)15.5(h)-433.3(a)-433.7(d)0(i)18.9(g)0(i)13.2(t)0(a)18.4(l)-435.6(ba)20.8(nd)15.5(-p)19.6(as)19.6(s)-434.4(f)0(i)17.3(l)0(t)16.5(e)0(r)-430.3([)0(2)19.6(0)0(])]TJ
0 -1.0527 TD
[(cen)-8.8(tred)-280.6(on)-280.4(the)-278.2(freque)-8.6(ncy)-281.5(of)-282(interest)-11.1(,)-279.2(with)-279.2(a)-280(bandw)-8.2(idth)-281(of)]TJ
T*
[(4)-296.7(Hz;)-299.2(the)-301(latter)-304.3(was)-298(found)-301.3(on)-291.8(sim)-9(ulated)-300.4(signa)-7.8(ls)-295.3(to)-294.1(be)-297.8(the)]TJ
T*
[(best)-530.6(compromi)-11.1(se)-521(for)-529(minimizin)-11.7(g)-518.6(the)-528.6(influence)-532.3(of)-521(the)]TJ
0 -1.0584 TD
[(other)-486.2(frequency)-483.6(compo)-7.4(nents)-480.1(while)-479.5(perm)-8.2(itting)-480.7(accurat)-10.9(e)]TJ
0 -1.0528 TD
[(foll)-9.4(owing)-351.6(of)-344.6(fast)-350.1(changes)-360.6(in)]TJ
/F5 1 Tf
11.8193 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 433.077 624.586 Tm
(rs)Tj
9.963 0 0 9.963 442.148 624.586 Tm
[(\(up)-356.7(to)-351(1)-347.9(Hz\).)-355.7(Next,)-351.6(the)]TJ
-13.333 -1.0527 TD
[(Fo)-6.4(urier)-356.9(coefficients)-358(of)-355.9(the)-357.9(signals)-360(were)-356.5(compu)-7.4(ted)-357.9(oscil-)]TJ
0 -1.0584 TD
[(latio)-11.4(n)-325.1(cycle)-337.5(by)-325.9(o)-6.5(scillation)-340.2(cycle)-331.8(and)-332.7(combined)-336.8(to)-334(obtain)]TJ
0 -1.0528 TD
[(the)-346.5(real)-349.3(\()]TJ
/F5 1 Tf
3.6932 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 352.12 593.064 Tm
(rs)Tj
9.963 0 0 9.963 357.789 593.064 Tm
[(\))-343.8(and)-344.1(ima)-8.2(ginary)-350.4(parts)-345.1(\()]TJ
/F5 1 Tf
9.3951 0 TD
(X)Tj
/F3 1 Tf
0.6032 0 TD
[(rs\))-348.1(of)]TJ
/F5 1 Tf
2.5437 0 TD
(Z)Tj
/F3 1 Tf
0.5577 0 TD
[(rs.)-346.1(The)-342.6(data)]TJ
-17.9651 -1.0528 TD
[(wer)-8.2(e)-593(corrected)-600.2(for)-597.3(the)-596.9(slight)-593.3(difference)-596.8(between)-599(the)]TJ
T*
[(dyn)-8(amic)-390.7(respon)-7.8(ses)-386.3(of)-390.1(the)]TJ
/F5 1 Tf
10.8689 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 423.609 572.088 Tm
(ao)Tj
9.963 0 0 9.963 434.891 572.088 Tm
(and)Tj
/F5 1 Tf
1.8267 0 TD
(V)Tj
/F10 1 Tf
0.6089 0 TD
(')Tj
/F3 1 Tf
0.6032 0 TD
[(press)-8.2(ure)-385.6(channel)-8.9(s)]TJ
-15.6433 -1.0584 TD
[(and)-429.5(for)-426.6(the)-426.2(2.1)-423(ms)-427(time)-432.5(constant)-428.3(of)-424.2(the)-426.2(p)-6.5(neumotacho-)]TJ
0 -1.0528 TD
[(graph.)-222.4(Gas)-218.4(volum)-9.3(e)-217.4(\()]TJ
/F5 1 Tf
8.0123 0 TD
(V)Tj
/F3 1 Tf
0.6089 0 TD
[(\))-212.9(was)-224.1(obtained)-222.2(by)-217.8(digital)-220.1(inte)-8.2(gration)]TJ
-8.6212 -1.0527 TD
(of)Tj
/F5 1 Tf
1.1438 0 TD
(V)Tj
/F10 1 Tf
0.6032 0 TD
(')Tj
/F3 1 Tf
0.0967 0 TD
[(,)-313.4(and)-321.4(the)-318.1(mean)-320(values)-321.9(of)]TJ
/F5 1 Tf
10.3056 0 TD
(V)Tj
/F10 1 Tf
0.7682 0 TD
(')Tj
/F3 1 Tf
0.4325 0 TD
(and)Tj
/F5 1 Tf
1.7584 0 TD
(V)Tj
/F3 1 Tf
0.9162 0 TD
[(corres)-9.8(pondin)-7(g)-313.7(t)0(o)]TJ
-16.0246 -1.0584 TD
[(each)-311.6(oscil)-10.2(lation)-308(c)-6.9(ycle)-307.8(were)-311(compu)-7.4(ted.)-312.7(Finally)56.2(,)-307.7(the)]TJ
/F5 1 Tf
20.4689 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 519.307 530.022 Tm
(rs)Tj
9.963 0 0 9.963 524.92 530.022 Tm
(,)Tj
/F5 1 Tf
0.5577 0 TD
(V)Tj
/F3 1 Tf
-22.1988 -1.0527 TD
(and)Tj
/F5 1 Tf
1.7698 0 TD
(V)Tj
/F10 1 Tf
0.6032 0 TD
(')Tj
/F3 1 Tf
0.5463 0 TD
[(data)-336.3(were)-333.7(smoothed)-337.6(in)-328.3(the)-329.4(time)-335.7(domain)-334.9(using)-331.8(an)]TJ
-2.9193 -1.0527 TD
[(eight)-9(-pole)-622.8(Butterwor)-12.5(th)-618.5(low-pas)-9.1(s)-610.9(fil)-8.6(ter)-615.6(wi)-7.8(th)-612.8(a)-621.4(cut-off)]TJ
0 -1.0584 TD
[(freque)-8.6(ncy)-230.3(of)-230.7(2)-222.7(Hz,)-233.9(and)-224.6(rejec)-9(ting)-229.7(a)-228.8(few)-230.2(outl)-7.8(ying)]TJ
/F5 1 Tf
18.8699 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 503.32 498.501 Tm
(rs)Tj
9.963 0 0 9.963 511.2 498.501 Tm
(values)Tj
-20.264 -1.0527 TD
[(\(appro)-8.2(xim)-7.8(ately)-333.7(2%)-328.3(of)-333.2(cycles\).)-336.5(Mean)-330.2(inspirat)-10.7(ory)-333.9(and)-327.1(ex-)]TJ
T*
[(pirat)-10.6(ory)]TJ
/F5 1 Tf
3.4371 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 349.568 477.524 Tm
(rs)Tj
9.963 0 0 9.963 358.186 477.524 Tm
[(wer)-8.2(e)-302.8(compu)-7.4(ted)-306.7(for)-301.4(each)-311.6(breathing)-309.9(cycle)-309(and)]TJ
-4.9053 -1.0527 TD
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T*
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[(\),)-293(co)15.1(rr)18(es)19.6(po)15.5(nd)15.5(i)13.9(n)0(g)-297.4(i)0(n)-288.4(t)0(i)16.5(m)0(e)-295.3(t)0(o)-294.1(e)0(a)14.7(c)0(h)]TJ
/F5 1 Tf
12.9745 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 212.995 558.198 Tm
(rs)Tj
9.963 0 0 9.963 221.556 558.198 Tm
[(va)15.1(lu)18.9(e,)-291.8(we)16.9(re)-293.7(al)12.8(so)]TJ
-16.3888 -1.0527 TD
[(co)15.1(mp)18.1(ut)18.9(ed)15.1(.)-290.6(T)12.2(hi)18.9(s)-292.2(w)0(a)16.9(s)-292.2(do)15.5(ne)-280.8(by)-286.1(es)19.6(ti)16.5(ma)17.7(ti)16.5(ng)-280.4(th)13.2(e)-291.4(i)0(n)18.9(s)0(t)17.7(a)0(n)20.8(t)0(a)12.8(n)0(e)20.8(o)0(u)15.5(s)]TJ
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/F5 1 Tf
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(P)Tj
/F3 1 Tf
7.97 0 0 7.97 153.921 537.279 Tm
(tp)Tj
9.963 0 0 9.963 162.085 537.279 Tm
(\()Tj
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7.97 0 0 7.97 171.156 537.279 Tm
[(dy)18.4(n)]TJ
9.963 0 0 9.963 182.835 537.279 Tm
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/F3 1 Tf
7.97 0 0 7.97 189.865 526.79 Tm
(0)Tj
9.963 0 0 9.963 196.157 526.79 Tm
[(an)20.8(d)]TJ
/F5 1 Tf
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/F3 1 Tf
7.97 0 0 7.97 218.551 526.79 Tm
(L)Tj
9.963 0 0 9.963 225.638 526.79 Tm
[(ob)15.5(ta)18.4(in)18.9(ed)-223.9(on)-223.5(th)13.2(e)]TJ
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(P)Tj
/F14 1 Tf
6.974 0 0 6.974 116.107 502.072 Tm
0.0001 Tc
[(dy)25(n)]TJ
/F15 1 Tf
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(\210)Tj
9.963 0 0 9.963 133.342 501.902 Tm
(\205)Tj
/F9 1 Tf
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/F14 1 Tf
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(ao)Tj
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/F9 1 Tf
9.963 0 0 9.963 157.436 501.902 Tm
(P)Tj
/F14 1 Tf
6.974 0 0 6.974 164.069 502.129 Tm
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[(oe)27(s)]TJ
/F15 1 Tf
9.963 0 0 9.963 173.877 501.902 Tm
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(\206)Tj
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(\377)Tj
9.963 0 0 9.963 183.628 501.902 Tm
(\205)Tj
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(P)Tj
/F14 1 Tf
6.974 0 0 6.974 194.116 502.129 Tm
(0)Tj
/F15 1 Tf
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/F9 1 Tf
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(E)Tj
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(L)Tj
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(V)Tj
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(\206\205)Tj
/F11 1 Tf
4.6378 0 TD
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(2)Tj
/F15 1 Tf
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(\206)Tj
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(P)Tj
/F3 1 Tf
7.97 0 0 7.97 64.233 486.935 Tm
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[(dy)-16.3(n)]TJ
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(R)Tj
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[(L,)21.9(0)]TJ
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[(.)-404.4(T)12.2(hi)13.2(s)-400.3(w)0(a)16.9(s)-406(on)15.5(ly)]TJ
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/F12 1 Tf
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(>)Tj
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[(0.)21.6(05)]TJ
-21.0778 -1.0527 TD
(L)Tj
/F9 1 Tf
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(.)Tj
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(s)Tj
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(-1)Tj
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(Results)Tj
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-1.0015 -1.0471 TD
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0 -1.0471 TD
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0 -1.0471 TD
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0 -1.0528 TD
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6.974 0 0 6.974 150.009 342.652 Tm
0.0001 Tc
(SD)Tj
9.963 0 0 9.963 158.74 342.652 Tm
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-10.0837 -1.0471 TD
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/F5 1 Tf
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(P)Tj
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7.97 0 0 7.97 170.986 332.22 Tm
-0.0139 Tc
(tp)Tj
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-12.0753 -1.0528 TD
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/F5 1 Tf
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(P)Tj
/F3 1 Tf
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-0.0139 Tc
(tp)Tj
9.963 0 0 9.963 214.696 321.732 Tm
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(.)Tj
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/F3 1 Tf
7.97 0 0 7.97 227.622 321.732 Tm
(L)Tj
9.963 0 0 9.963 236.92 321.732 Tm
[(ra)19.2(ng)15.5(ed)-440.1(6.)15.9(2\213)]TJ
-17.9309 -1.0471 TD
[(0.)15.9(9\261)21.2(10)15.5(.8)21.6(\2130)16.7(.7)-257.2(hP)16.3(a)]TJ
/F9 1 Tf
6.9197 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(L)Tj
7.472 0 0 6.641 135.893 315.723 Tm
-0.0185 Tc
(-1)Tj
9.963 0 0 9.963 144.567 311.301 Tm
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-8.661 -1.0527 TD
[(be)15.1(tw)20.6(ee)14.7(n)-387.7(s)0(u)14.4(c)0(c)20.4(e)0(s)13.9(s)0(i)17.7(v)0(e)-377.5(m)0(e)12(a)0(s)19.6(u)0(r)19.6(e)0(m)12(e)0(n)20.8(t)0(s)-380.7(w)0(a)11.2(s)-388.9(1)39.1(1)0(.)21.6(2)0(\213)-381.6(5)0(.)15.9(2)0(%)18.9(.)-393(T)12.2(h)0(e)]TJ
0 -1.0471 TD
[(me)17.7(an)-286.5(va)15.1(lu)18.9(es)-287.6(of)-282(in)13.2(sp)20(ir)17.3(at)18.5(or)13.9(y)-291(a)0(n)15.1(d)-291(ex)15.1(pi)18.9(ra)19.2(to)13.2(ry)]TJ
/F5 1 Tf
16.77 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 231.307 290.381 Tm
(L)Tj
9.963 0 0 9.963 239.074 290.381 Tm
[(an)20.8(d)]TJ
/F5 1 Tf
1.7129 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 262.035 290.381 Tm
(rs)Tj
9.963 0 0 9.963 270.539 290.381 Tm
[(at)-288.8(8)]TJ
-21.3054 -1.0528 TD
[(Hz)-358.7(in)-356.7(in)18.9(di)18.9(vi)18.9(du)15.5(al)-357.1(pa)20.8(ti)16.5(en)15.1(ts)-352.2(ar)13.5(e)-365.4(s)0(h)20(o)0(w)17.3(n)-365(in)-356.7(ta)18.4(bl)18.9(e)-365.4(2)0(.)-365.3(For)-378.7(both)]TJ
0 -1.0471 TD
[(inspirat)-10.7(ion)-232.3(and)-224.6(e)-6.9(xpiration)-10.3(,)]TJ
/F5 1 Tf
10.6243 0 TD
(R)Tj
/F3 1 Tf
0.6089 0 TD
[(rs)-226.2(was)-235.4(similar)-235.1(to)-231.5(or)]TJ
/F12 1 Tf
7.7221 0 TD
(>)Tj
/F5 1 Tf
0.552 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 258.633 269.461 Tm
(L)Tj
9.963 0 0 9.963 265.72 269.461 Tm
[(in)-225.8(all)]TJ
-20.8217 -1.0527 TD
[(but)-346.1(one)-338.4(pati)-8.2(ent)-340.8(\(subj)-9(ect)-341.2(2\),)-344.9(in)-339.7(whom)-345.9(signi)-9.8(ficantly)-351.4(lower)]TJ
0 -1.0471 TD
[(values)-356.1(were)-350.8(found)-358.2(using)-348.8(FOT)64.4(.)-347.5(Mean)]TJ
/F5 1 Tf
15.3531 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 217.247 248.542 Tm
(L)Tj
9.963 0 0 9.963 225.524 248.542 Tm
(and)Tj
/F5 1 Tf
1.7868 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 249.392 248.542 Tm
(rs)Tj
9.963 0 0 9.963 258.463 248.542 Tm
[(for)-352.6(the)]TJ
-20.0933 -1.0528 TD
[(whole)-460.1(group)-455(were)-458.9(not)-454.2(signifi)-9.6(cantly)-454(different)-455.4(and)-452.2(wer)-8.2(e)]TJ
T*
[(signifi)-9.6(cantly)-419.9(correlated)-11.5(;)-418.6(the)-414.8(correlati)-12.7(on)-416.9(was)-417.5(even)-413.6(bett)-8.2(er)]TJ
0 -1.0471 TD
[(when)-491.1(the)-494.5(outl)-7.8(ying)-489.1(pati)-8.2(ent)-488.8(was)-491.5(exclud)-7.8(ed)-491.3(\(r)]TJ
/F12 1 Tf
18.0959 0 TD
(=)Tj
/F3 1 Tf
0.552 0 TD
[(0.91)25.8(1)-490.2(and)]TJ
-18.6479 -1.0527 TD
[(0.751)-435.9(for)-438(inspirat)-10.7(ory)-436.4(and)-435.2(expiratory)-443.2(data,)-439.1(respec)-8.6(tively\))]TJ
0 -1.0471 TD
[(\(fig.)-657.7(1a\).)-653.4(In)-651.8(the)-648.1(pati)-8.2(ent)-653.8(who)-649.3(exhibi)-9.7(ted)-653.8(the)-648.1(great)-8.6(est)]TJ
0 -1.0527 TD
[(varia)-8.6(bility)-344.2(of)-344.6(resistanc)-11.1(e)-336.9(betw)-9.8(een)-338.8(repeat)-9.8(ed)-343.4(measurem)-10.7(ents)]TJ
0 -1.0471 TD
[(\(subje)-10.1(ct)-300.2(1\),)-305.1(signi)-9.8(ficant)-307.6(correla)-12.1(tions)-305.7(were)-305.3(also)-308.6(presen)-8.2(t)-304.7(be-)]TJ
0 -1.0528 TD
[(tween)-341(succes)-8.2(sive)-342.8(estimates)-345.1(of)]TJ
/F5 1 Tf
12.394 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 187.767 164.806 Tm
(L)Tj
9.963 0 0 9.963 195.931 164.806 Tm
(and)Tj
/F5 1 Tf
1.7754 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 219.628 164.806 Tm
(rs)Tj
9.963 0 0 9.963 228.642 164.806 Tm
[(on)-337.3(both)-335.5(inspi)-9.8(-)]TJ
-17.1001 -1.0471 TD
[(ration)-460.9(and)-463.6(expiratio)-10.7(n)-456(\(table)-461.3(2\).)]TJ
/F5 1 Tf
13.3614 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 197.461 154.375 Tm
(L,ex)Tj
9.963 0 0 9.963 216.227 154.375 Tm
[(was)-457.4(signi)-9.8(ficantly)]TJ
-15.8539 -1.0528 TD
[(great)-8.6(er)-322.2(than)]TJ
/F5 1 Tf
5.0817 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 114.973 143.887 Tm
(L,in)Tj
9.963 0 0 9.963 131.074 143.887 Tm
[(in)-316.9(six)-324.5(patients,)-328.6(and)-321.4(signifi)-9.6(cantly)-328.8(lower)]TJ
-7.3067 -1.0471 TD
[(in)-271.4(one)-264.5(pati)-8.2(ent)-266.8(\(tabl)-10.6(e)-268.6(2\):)-268(differences)-268.7(in)-271.4(the)-266.8(same)-275.7(direction)-10.7(,)]TJ
0 -1.0528 TD
[(althou)-9.7(gh)-217.8(not)-220.9(always)-223.4(signifi)-9.6(cant,)-222.9(were)-225.6(seen)-221.3(for)]TJ
/F5 1 Tf
18.2951 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 246.557 122.967 Tm
(rs)Tj
9.963 0 0 9.963 252.17 122.967 Tm
[(,)-222.3(and)-218.9(the)]TJ
-19.4617 -1.0471 TD
[(differences)-667.1(observ)-7.8(ed)-667.7(with)-666.2(the)-670.9(two)-668.7(approac)-8.1(hes)-664(wer)-8.2(e)]TJ
25.1977 46.8332 TD
[(signi)-9.8(ficantly)-556.3(correlated)-557.8(\(r)]TJ
/F12 1 Tf
10.6356 0 TD
(=)Tj
/F3 1 Tf
0.552 0 TD
[(0.621,)-555.8(p)]TJ
/F12 1 Tf
3.5566 0 TD
(<)Tj
/F3 1 Tf
0.552 0 TD
[(0.001,)-550.1(for)-551.8(the)-551.4(49)]TJ
-15.2962 -1.0698 TD
[(meas)-8.2(urem)-8.2(ents\).)]TJ
1.0015 -1.0471 TD
[(In)13.9(sp)20(ir)17.3(at)18.4(or)14(y)-467.4(a)0(n)15.1(d)-473.1(ex)20.8(pi)18.9(ra)13.5(to)18.9(ry)]TJ
/F5 1 Tf
11.0567 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 435.345 558.028 Tm
(rs)Tj
9.963 0 0 9.963 445.606 558.028 Tm
[(de)15.1(cr)19.2(ea)14.7(se)19.6(d)-473.1(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)12.8(a)0(n)20.8(t)0(l)16.5(y)]TJ
-13.6801 -1.0641 TD
[(fr)12.4(om)-454.2(8\261)15.5(16)-456.8(H)12.4(z)-467.8(in)-459.2(al)18.5(l)-464.1(b)0(u)15.5(t)-464.1(on)21.2(e)-467.8(p)0(a)15.1(t)0(i)22.2(e)0(n)15.1(t)-464.1(\(s)18.4(ub)15.5(je)18.4(ct)-459.6(6\))19.6(.)-467(A)0(s)-456.2(a)]TJ
T*
[(co)15.1(ns)20(eq)15.1(ue)20.8(nc)15.1(e,)]TJ
/F5 1 Tf
5.4971 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 370.035 536.825 Tm
(rs)Tj
9.963 0 0 9.963 378.312 536.825 Tm
[(at)-260.4(16)-269(H)12.4(z)-274.3(wa)16.9(s,)-264.1(on)-263.3(av)15.1(er)19.2(ag)15.1(e,)-263.3(sl)17.7(ig)18.8(ht)18.8(ly)-265.7(lo)18.9(we)16.9(r)]TJ
-6.9254 -1.0698 TD
[(th)13.2(an)]TJ
/F5 1 Tf
1.912 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 334.261 526.167 Tm
(L)Tj
9.963 0 0 9.963 341.348 526.167 Tm
[(\(8)19.6(.2)15.9(1\213)16.7(1.)21.6(96)]TJ
/F5 1 Tf
4.5069 0 TD
[(ve)14.7(rs)18.9(us)]TJ
/F3 1 Tf
2.7144 0 TD
[(10)21.2(.4)15.9(8\213)16.7(3.)21.6(74)15.5(,)-228(p)]TJ
/F12 1 Tf
5.4174 0 TD
(<)Tj
/F3 1 Tf
0.5406 0 TD
[(0.)15.9(00)21.2(1,)-217.4(on)-217.8(in)13.2(sp)20(ir)28.6(-)]TJ
-16.3945 -1.0641 TD
[(at)12.8(io)18.9(n;)-442.1(9.)21.6(20)15.5(\213)11.8(1)0(.)15.9(9)0(7)]TJ
/F5 1 Tf
7.0734 0 TD
[(ve)14.7(rs)18.8(us)]TJ
/F3 1 Tf
2.9363 0 TD
[(1)44.8(1)0(.)15.9(8)0(1)15.5(\213)11.8(4.)15.9(56)21.2(,)-449.9(p)]TJ
/F12 1 Tf
5.6052 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(00)15.5(1,)-439.3(on)-439.7(ex)15.1(pi)18.9(r)20.4(-)]TJ
-16.1612 -1.0641 TD
[(at)12.8(io)18.9(n\))19.6(;)-270.6(t)0(h)18.9(e)-268.6(co)15.1(rr)18(el)18.4(at)18.5(io)18.9(ns)-258.8(be)15.1(tw)14.9(ee)20.4(n)-268.2(t)0(h)13.2(e)-262.9(tw)14.9(o)-268.2(e)0(s)13.9(t)0(i)22.2(m)0(a)12(t)0(e)18.4(s)-269.4(w)12.4(e)0(r)13.5(e)0(,)-257.6(i)0(n)]TJ
T*
[(ge)15.1(ne)15.1(ra)19.2(l,)-345(a)-354(l)0(i)16.5(t)0(t)16.5(l)0(e)-345.7(l)0(e)18.4(s)0(s)-351(t)13.9(ha)15.1(n)-353.6(a)0(t)-345.7(8)-359.3(H)12.4(z)-359.7(\(r)]TJ
/F12 1 Tf
14.2207 0 TD
(=)Tj
/F3 1 Tf
0.5406 0 TD
[(0.)15.9(78)21.2(8)-359.3(a)0(n)20.8(d)-353.6(0.)15.9(63)15.5(4)-353.6(f)0(o)19.6(r)]TJ
-14.7613 -1.0641 TD
[(in)13.2(sp)20(ir)17.3(at)18.5(io)18.9(n)-456(a)0(n)20.8(d)-450.3(ex)15.1(pi)18.9(ra)19.2(ti)16.5(on)15.5(,)-449.9(r)0(e)19.2(s)0(p)14.3(e)0(c)20.4(t)0(i)16.5(v)0(e)15.1(l)0(y)81.4(,)-449.9(wh)17.3(en)-440.1(ex)15.1(cl)18.4(ud)15.5(in)18.8(g)]TJ
T*
[(th)13.2(e)-319.8(o)0(u)15.5(t)0(l)16.5(y)0(i)18.9(n)0(g)-314.5(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(\))-318.5(\()0(f)18(i)0(g)18.9(.)-324.7(1b)21.2(\).)]TJ
1.0015 -1.0527 TD
[(Re)16.1(sp)14.4(ir)17.3(at)18.4(or)19.6(y)-507.2(p)0(h)15.5(a)0(s)19.6(i)0(c)-499.4(v)0(a)15.1(r)0(i)17.3(a)0(t)18.4(i)0(o)18.8(n)0(s)-503.5(o)0(f)-498.2(i)0(n)18.9(s)0(t)17.7(a)0(n)15.1(t)13.9(an)15.1(eo)15.1(us)-497.8(re)19.2(si)17.7(st)17.7(-)]TJ
-1.0015 -1.0641 TD
[(an)15.1(ce)14.7(s)-303.6(c)0(o)20.8(u)0(l)18.9(d)-308.1(be)-292.2(de)15.1(t)13.9(e)0(c)14.7(t)0(e)18.4(d)-302.4(in)-299.8(al)18.5(l)-304.7(t)0(h)18.9(e)-302.8(re)19.2(co)15.1(rd)19.6(s)-303.6(i)0(n)-299.8(f)0(i)17.3(v)0(e)-292.2(p)0(a)15.1(t)0(i)22.2(e)0(n)15.1(t)0(s)17.7(,)]TJ
T*
[(an)15.1(d)-262.5(o)0(n)15.5(l)0(y)-254.3(o)0(c)20.8(c)0(a)14.7(s)0(i)17.7(o)0(n)21.2(a)0(l)12.8(l)13.9(y)-268.2(e)0(m)17.7(e)0(r)30.6(g)0(e)15.1(d)-262.5(fr)18(om)-255.1(th)18.8(e)-262.9(n)0(o)15.5(i)0(s)17.7(e)-262.9(in)-254.3(th)18.9(e)-262.9(o)0(t)13.2(h)0(e)20.8(r)]TJ
T*
[(tw)14.9(o.)-268.6(F)11.4(o)0(r)-264.9(c)0(o)15.1(m)0(p)18.1(a)0(r)13.5(i)13.9(ng)]TJ
/F5 1 Tf
8.0635 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 395.603 430.866 Tm
-0.0161 Tc
(rs)Tj
9.963 0 0 9.963 403.88 430.866 Tm
0 Tc
[(an)20.8(d)]TJ
/F5 1 Tf
1.6958 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 426.671 430.866 Tm
0.0001 Tc
[(L,)21.9(0)]TJ
9.963 0 0 9.963 440.05 430.866 Tm
0 Tc
[(va)20.8(ri)17.3(at)12.8(io)18.9(ns)20(,)-273.5(t)0(h)13.2(e)-274.3(re)19.2(co)15.1(rd)19.6(s)-275.1(i)0(n)]TJ
-13.1224 -1.0641 TD
[(wh)17.3(ic)12.8(h)-222.7(t)0(h)18.8(e)-223.1(pe)15.1(ri)17.3(od)21.2(ic)-214.9(ch)15.1(an)20.8(ge)15.1(s)-223.9(i)0(n)]TJ
/F5 1 Tf
11.7794 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 432.567 420.264 Tm
(rs)Tj
9.963 0 0 9.963 440.334 420.264 Tm
[(we)11.2(re)-214.1(th)18.9(e)-223.1(m)0(o)18.1(s)0(t)-215.6(p)0(r)19.6(o)0(m)12.4(i)0(n)18.8(e)0(n)20.8(t)]TJ
-13.1509 -1.0698 TD
[(an)15.1(d)-467.4(r)0(e)19.2(g)0(u)15.5(l)0(a)18.4(r)-469(we)16.9(re)-458.8(se)13.9(le)18.4(ct)18.5(ed)-462.9(fo)19.6(r)-469(e)0(a)20.4(c)0(h)-462.9(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(.)-458.8(F)11.4(ro)13.9(m)-464.9(t)0(h)13.2(e)0(s)19.6(e)]TJ
0 -1.0641 TD
[(re)13.5(co)20.8(rd)14(s,)-247(us)14.4(i)13.9(n)0(g)-251.9(l)0(i)16.5(n)0(e)20.8(a)0(r)-253.9(i)0(n)18.8(t)0(e)18.4(r)0(p)13.9(o)0(l)18.9(a)0(t)18.5(i)0(o)18.9(n)0(,)-251.5(b)0(l)18.9(o)0(c)15.1(k)0(-)19.6(a)0(v)15.1(e)0(r)19.2(a)0(g)15.1(e)0(d)-246.6(r)0(e)13.5(s)0(p)20(i)0(r)17.3(a)0(-)]TJ
T*
[(to)13.2(ry)-230.8(cy)20.8(cl)18.5(es)-236.4(of)]TJ
/F5 1 Tf
5.5255 0 TD
(V)Tj
/F10 1 Tf
0.5918 0 TD
(')Tj
/F3 1 Tf
0.0854 0 TD
(,)Tj
/F5 1 Tf
0.4894 0 TD
(V)Tj
/F3 1 Tf
0.4723 0 TD
(,)Tj
/F5 1 Tf
0.4837 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 391.464 388.403 Tm
(tp)Tj
9.963 0 0 9.963 397.417 388.403 Tm
(,)Tj
/F5 1 Tf
0.4894 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 408.246 388.403 Tm
(rs)Tj
9.963 0 0 9.963 416.183 388.403 Tm
[(an)15.1(d)]TJ
/F5 1 Tf
1.6616 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 438.633 388.403 Tm
0.0001 Tc
[(L,)21.9(0)]TJ
9.963 0 0 9.963 451.616 388.403 Tm
0 Tc
[(we)11.2(re)-231.2(bu)21.2(il)16.5(t)-242.1(w)12.4(it)16.5(h)-239.8(a)-240.2(ti)16.5(me)]TJ
-14.2833 -1.0641 TD
[(re)13.5(so)20(lu)18.9(ti)16.5(on)-582(co)20.8(rr)12.4(es)19.6(po)15.5(nd)21.2(in)18.9(g)-592.6(a)0(p)20.8(p)0(r)13.9(o)0(x)21.2(i)0(m)15.7(a)0(t)18.5(e)0(l)18.5(y)-592.6(to)-578.7(th)18.8(at)-579.1(of)-583.6(th)18.9(e)]TJ
T*
[(fo)13.9(rc)19.2(ed)-479.9(os)20(ci)18.4(ll)16.5(at)12.8(i)13.9(o)0(n)-479.5(m)0(e)17.7(a)0(s)13.9(u)0(r)19.6(e)0(m)17.7(e)0(n)15.1(t)0(s)-477.4(\()0(2)13.9(4)-484.5(an)15.1(d)-484.5(4)0(8)-479.5(p)0(o)21.2(i)0(n)18.9(t)0(s)-483.1(p)0(e)20.8(r)]TJ
T*
[(re)13.5(sp)20(ir)17.3(at)18.5(or)14(y)-347.9(c)0(y)20.8(c)0(l)18.4(e)-348.3(fo)19.6(r)-349.5(t)0(h)18.8(e)-348.3(8)-347.9(a)0(n)20.8(d)-347.9(16)-337.3(Hz)-335.9(da)15.1(ta)18.4(,)-347.5(r)0(e)19.2(s)0(p)14.3(e)0(c)20.4(t)0(i)16.5(v)0(e)15.1(l)0(y)18.9(\))0(.)]TJ
0 -1.0698 TD
[(Th)17.1(e)-234.5(a)0(m)17.7(p)0(l)18.8(i)0(t)16.5(u)0(d)15.5(e)0(s)-219.4(o)0(f)-225.1(t)0(h)18.8(e)-228.8(va)15.1(ri)17.3(at)18.5(io)18.8(ns)-224.7(in)]TJ
/F5 1 Tf
13.7484 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 452.239 345.94 Tm
(rs)Tj
9.963 0 0 9.963 460.12 345.94 Tm
[(de)20.8(cr)13.5(ea)20.4(se)14(d)-228.4(f)0(r)18(o)0(m)-226.6(8)-228.4(to)]TJ
-15.1369 -1.0641 TD
[(16)-229.2(H)12.4(z)-234.5(in)-225.8(al)12.8(l)-230.8(i)0(n)18.8(s)0(t)12(a)0(n)20.8(c)0(e)14.7(s)-229.6(\(t)17.3(ab)15.1(le)-226.2(3\).)-236.8(At)-246.8(8)-245.5(Hz,)-245.2(they)-244.8(wer)-8.2(e)-245.9(similar)]TJ
T*
[(to)-220.2(those)-224(of)]TJ
/F5 1 Tf
4.3476 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 358.639 324.737 Tm
0.0001 Tc
(L,0)Tj
9.963 0 0 9.963 371.565 324.737 Tm
0 Tc
[(in)-214.5(four)-222.5(pati)-8.2(ents,)-218(and)-218.9(subst)-8.6(antially)-227(lar)10.4(ger)-220.5(in)]TJ
-6.2482 -1.0641 TD
[(the)-352.2(other)-349.6(three)-350(\(table)-353.2(3\).)]TJ
/F5 1 Tf
10.2601 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 417.6 314.135 Tm
(rs)Tj
9.963 0 0 9.963 426.614 314.135 Tm
(and)Tj
/F5 1 Tf
1.7868 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 450.425 314.135 Tm
0.0001 Tc
(L,0)Tj
9.963 0 0 9.963 464.655 314.135 Tm
0 Tc
[(were)-350.8(signifi)-9.6(cantly)]TJ
-15.5921 -1.0641 TD
[(correl)-11(ated)-495.6(in)-493.3(all)-496.8(patients,)-499.3(but)-494.1(the)-494.5(correl)-11(ations)-494.6(wer)-8.2(e)-490.6(i)0(n)]TJ
T*
[(gen)-8.4(erally)-256.4(less)-258.6(at)-254.7(16)-251.9(than)-256.2(at)-254.7(8)-251.2(H)0(z)-256.2(\(tabl)-10.6(e)-251.6(3\).)-253.9(The)-257.2(patterns)-259.1(of)]TJ
0 -1.0698 TD
[(varia)-8.6(tion)-315.1(wer)-8.2(e,)-314.5(for)-318.5(both)]TJ
/F5 1 Tf
9.8674 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 413.631 282.274 Tm
(rs)Tj
9.963 0 0 9.963 422.362 282.274 Tm
(and)Tj
/F5 1 Tf
1.7527 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 445.89 282.274 Tm
0.0001 Tc
(L,0)Tj
9.963 0 0 9.963 456.661 282.274 Tm
0 Tc
[(,)-313.4(fairly)-320.2(reprod)-8.2(ucible)]TJ
-14.7897 -1.0641 TD
[(betw)-9.8(een)-395.8(succes)-8.2(sive)-399.7(meas)-8.2(urem)-8.2(ents)-399.7(in)-396.6(an)-400.3(individua)-8.7(l,)-396.2(but)]TJ
T*
[(varie)-8.6(d)-370.7(among)-371.6(pati)-8.2(ents,)-371.6(as)-373(illustrated)-382.4(in)-368.1(figur)-9.4(e)-365.4(2)0(.)-371(I)0(n)-373(two)]TJ
T*
[(pati)-8.2(ents)-240.3(\(No)-7.8(s.)-241.3(1)-239.8(and)-241.7(2\))-242.1(both)]TJ
/F5 1 Tf
11.2388 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 427.294 250.469 Tm
(rs)Tj
9.963 0 0 9.963 435.288 250.469 Tm
(and)Tj
/F5 1 Tf
1.6787 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 458.079 250.469 Tm
0.0001 Tc
(L,0)Tj
9.963 0 0 9.963 471.175 250.469 Tm
0 Tc
[(ap)-7.6(peared)-246.4(lar)10.4(gely)]TJ
-16.2465 -1.0641 TD
[(relat)-11(ed)-423(to)-430.7(absolute)-434(respirato)-11.1(ry)-424.2(flow)57.3(,)-427.2(being)-427.7(min)-7.8(imum)-427.1(at)]TJ
T*
[(end)-8.4(-inspiration)-621(and)-605.9(expir)-8.2(ation,)-612.6(and)-611.6(maximum)-615.1(in)-607.1(the)]TJ
0 -1.0698 TD
[(vici)-8.2(nity)-286.7(of)-282(peak)-288.4(inspiratory)-293.5(and)-281.5(expir)-8.2(atory)-287(flow)-289.8(\(fig.)-282.1(2a)-7.6(\);)]TJ
0 -1.0641 TD
[(the)-380.7(flow)-380.8(dependen)-7.3(ce)-377.9(of)-373(8-H)-7.8(z)]TJ
/F5 1 Tf
12.4054 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 438.916 208.006 Tm
(rs)Tj
9.963 0 0 9.963 448.271 208.006 Tm
[(was)-377.7(sim)-9(ilar)-379.7(to)-373.8(that)-378.1(of)]TJ
/F5 1 Tf
-13.9475 -1.0641 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 315.383 197.405 Tm
(L,0)Tj
9.963 0 0 9.963 328.932 197.405 Tm
[(in)-282.7(one)-287.2(case)-284.3(\(subject)-287.6(2\))-287.7(and)-281.5(much)-285.4(larger)-278.4(in)-282.8(the)-289.6(other)48.7(.)]TJ
-1.9689 -1.0641 TD
[(In)-225.1(tw)-7.8(o)-222.7(patients)-231.5(\(subjects)-232.7(3)-222.7(and)-224.6(7,)-223.1(not)-226.6(shown\),)]TJ
/F5 1 Tf
18.0618 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 495.269 186.803 Tm
(rs)Tj
9.963 0 0 9.963 503.149 186.803 Tm
(and)Tj
/F5 1 Tf
1.6616 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 525.713 186.803 Tm
0.0001 Tc
(L,0)Tj
9.963 0 0 9.963 309.316 176.202 Tm
0 Tc
[(varie)-8.6(d)-382(substantiall)-12.9(y)-376.4(w)0(i)-7.8(t)0(h)-379.5(volume,)-386.5(being)-382.2(much)-382.2(higher)-384.5(at)]TJ
0 -1.0641 TD
[(end)-8.4(-expiration)-503.2(than)-489.5(at)-493.7(end-i)-8.2(nspirati)-10.7(on,)-491.3(with)-495.4(almost)-497.8(no)]TJ
T*
[(\(subj)-9(ect)-324.2(3\))-327.5(or)-327.5(less)-326.9(\(subject)-333.1(7\))-327.5(flow-dep)-10.3(endence.)-331.7(The)-325.5(last)]TJ
0 -1.0698 TD
[(three)-207.8(cases)-200.9(exhibi)-9.7(ted)-198.6(predom)-9.7(inantly)-206.4(flow-dep)-10.3(endent)-206.9(\(sub-)]TJ
0 -1.0641 TD
[(ject)-8.6(s)-269.4(5)-268.2(and)-270.1(6\))-270.6(or)-270.6(volum)-9.3(e-depen)-8.1(dent)-273.3(\(subject)-276.2(4\))-270.6(varia)-8.6(tions)]TJ
T*
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[(,)-358.9(a)0(l)18.5(t)0(h)18.9(o)0(u)15.5(g)0(h)-348.7(t)0(h)18.9(e)-359.7(co)20.8(rr)18(el)12.8(at)18.4(io)18.9(ns)-349.8(we)16.9(re)-350.7(us)20(ua)15.1(l)13.9(l)0(y)-351(l)0(e)18.4(s)0(s)-351(t)0(h)18.9(a)0(n)-349.1(a)0(t)-351.4(8)]TJ
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0 -1.0471 TD
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0 -1.0528 TD
[(ti)16.5(on)21.2(s.)-315.3(G)]TJ
6.974 0 0 6.974 89.745 143.887 Tm
0.0001 Tc
[(RIM)19.7(B)0(Y)]TJ
/F5 1 Tf
9.963 0 0 9.963 114.633 143.887 Tm
0 Tc
[(et)-311.6(al)]TJ
/F3 1 Tf
1.7698 0 TD
[(.)-324.7([)0(8)19.6(])-332.4(and)-332.8(N)]TJ
6.974 0 0 6.974 177.279 143.887 Tm
0.0001 Tc
(AGELS)Tj
/F5 1 Tf
9.963 0 0 9.963 202.904 143.887 Tm
0 Tc
[(et)-334.4(al)]TJ
/F3 1 Tf
1.8096 0 TD
[(.)-330.4([15])-336.3(compa)-7.8(red)]TJ
-16.3262 -1.0471 TD
[(values)-219.5(of)]TJ
/F5 1 Tf
3.7842 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 101.991 133.455 Tm
(L)Tj
9.963 0 0 9.963 108.907 133.455 Tm
[(obtai)-9(ned)-213.2(by)-212.1(FOT)-157.5(at)-214.9(3\2614)-212.8(Hz)-216.4(to)]TJ
/F5 1 Tf
11.8705 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 233.178 133.455 Tm
(L,sb)Tj
9.963 0 0 9.963 249.109 133.455 Tm
[(in)-214.5(COPD)]TJ
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[(patien)-10.1(ts;)-315.5(they)-324.5(observ)-7.8(ed)-320.6(that)-321.2(the)-318.1(FOT)-259.9(yielded)-323.9(syst)-7.8(ematic-)]TJ
0 -1.0471 TD
[(ally)-355.3(lower)-359.2(values)-356.1(when)]TJ
/F5 1 Tf
9.8333 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 162.255 112.535 Tm
(L,sb)Tj
9.963 0 0 9.963 179.603 112.535 Tm
[(exceeded)-355.3(approxi)-9.7(mately)-360.4(5)]TJ
13.02 43.9595 TD
[(hP)-6.4(a)]TJ
/F9 1 Tf
1.4966 0.1992 TD
(.)Tj
/F3 1 Tf
0.2675 -0.1992 TD
(L)Tj
7.472 0 0 6.641 332.957 554.91 Tm
(-1)Tj
/F9 1 Tf
9.963 0 0 9.963 339.08 552.472 Tm
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(s)Tj
7.472 0 0 6.641 345.657 554.91 Tm
(-1)Tj
9.963 0 0 9.963 351.779 550.488 Tm
[(.)-205.2(I)0(n)-208(contr)-8.2(ast,)-205.8(a)-206(line)-8.2(ar)-208.4(relations)-11.9(hip)-203.8(betw)-9.8(een)-208(8-Hz)]TJ
/F5 1 Tf
-4.2622 -1.0755 TD
(R)Tj
/F3 1 Tf
0.6089 0 TD
[(rs)-351.4(and)]TJ
/F5 1 Tf
2.851 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 349.852 539.773 Tm
(L,sb)Tj
9.963 0 0 9.963 367.2 539.773 Tm
[(was)-354.9(observ)-7.8(ed)-354.7(in)-351(the)-357.9(presen)-8.2(t)-356(study)60.9(,)-353.2(with)-358.9(a)]TJ
-5.8101 -1.0698 TD
[(slope)-400.4(close)-395.2(to)-396.6(unity)59.7(,)-393(u)0(p)-394.2(t)0(o)-390.9(resistanc)-11.1(es)-395.8(of)-390.1(12)-394.2(hPa)]TJ
/F9 1 Tf
20.0307 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(L)Tj
7.472 0 0 6.641 517.606 533.537 Tm
(-1)Tj
/F9 1 Tf
9.963 0 0 9.963 523.786 531.099 Tm
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(s)Tj
7.472 0 0 6.641 530.305 533.537 Tm
(-1)Tj
9.963 0 0 9.963 309.316 518.4 Tm
[(\(fig)-8.6(.)-176.8(1a\);)-183.8(it)-182.7(was)-184.2(only)-181.8(when)]TJ
/F5 1 Tf
10.2999 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 417.94 518.4 Tm
(L,sb)Tj
9.963 0 0 9.963 433.587 518.4 Tm
[(was)-178.5(close)-184.6(to)-186(20)-177.9(hPa)]TJ
/F9 1 Tf
7.5571 0.2049 TD
(.)Tj
/F3 1 Tf
0.2731 -0.2049 TD
(L)Tj
7.472 0 0 6.641 517.606 522.822 Tm
(-1)Tj
/F9 1 Tf
9.963 0 0 9.963 523.786 520.441 Tm
(.)Tj
/F3 1 Tf
0.2731 -0.2049 TD
(s)Tj
7.472 0 0 6.641 530.305 522.822 Tm
(-1)Tj
9.963 0 0 9.963 309.316 507.742 Tm
[(\(subj)-9(ect)-574.5(2\))-572.2(that)-571.6(the)-574.1(8-H)-7.8(z)]TJ
/F5 1 Tf
11.4835 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 429.732 507.742 Tm
(rs)Tj
9.963 0 0 9.963 441.071 507.742 Tm
[(was)-571.2(clear)-9(ly)-573(below)-573.9(the)]TJ
-13.2248 -1.0755 TD
[(ident)-9(ity)-217.6(line;)-221.9(even)-220.1(at)-214.9(16)-217.8(Hz,)]TJ
/F5 1 Tf
11.0738 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 425.65 497.027 Tm
(rs)Tj
9.963 0 0 9.963 433.417 497.027 Tm
[(rema)-8.6(ined)-216.4(close)-224.4(to)]TJ
/F5 1 Tf
7.136 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 510.52 497.027 Tm
(L,sb)Tj
9.963 0 0 9.963 526.507 497.027 Tm
(up)Tj
-21.8005 -1.0698 TD
[(to)-442.1(values)-441.4(of)-441.3(10)-434(hP)-6.4(a)]TJ
/F9 1 Tf
8.3765 0.1992 TD
(.)Tj
/F3 1 Tf
0.2675 -0.1992 TD
(L)Tj
7.472 0 0 6.641 401.499 490.79 Tm
(-1)Tj
/F9 1 Tf
9.963 0 0 9.963 407.622 488.353 Tm
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(s)Tj
7.472 0 0 6.641 414.198 490.79 Tm
(-1)Tj
9.963 0 0 9.963 420.321 486.368 Tm
[(.)-438.6(I)0(n)-441.3(other)-440.7(words,)-443.4(these)-440.7(data)]TJ
-11.1421 -1.0755 TD
[(show)-8.2(ed)-303.5(much)-302.5(less)-304.1(n)-6.5(egative)-307.2(freque)-8.6(ncy-dep)-7.7(endence)-308.6(of)-299(re-)]TJ
0 -1.0698 TD
[(sista)-11.4(nce)-276.2(in)-282.7(obstructi)-11.5(ve)-280.8(patients)-282.7(than)-284.7(previ)-8.2(ously)-280.5(observ)-7.8(ed.)]TJ
0 -1.0755 TD
[(A)-289.2(minor)-289.8(reason)-292.7(for)-290(the)-283.9(d)-6.5(iscrepancy)-293.2(may)-290.4(be)-286.5(that)-287.1(FOT)]TJ
/F5 1 Tf
21.6298 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 530.872 454.28 Tm
(rs)Tj
9.963 0 0 9.963 309.316 443.622 Tm
[(whi)-8.6(ch)-280.8(also)-280.2(incl)-8.2(udes)-283.5(the)-283.9(resistanc)-11.1(e)-280(o)0(f)-282(the)-283.9(chest)-281.3(wall)-285.3(\()]TJ
/F5 1 Tf
21.0493 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 525.033 443.622 Tm
(w)Tj
9.963 0 0 9.963 530.759 443.622 Tm
(\),)Tj
-22.2273 -1.0755 TD
[(was)-446(meas)-8.2(ured;)-440.7(the)-443.2(latter)20(,)-438.6(howe)-7.4(ver)29.9(,)-438.6(has)-442.1(been)-447.7(shown)-441.4(to)]TJ
0 -1.0698 TD
[(dec)-8.8(rease)-246.8(wi)-7.8(th)-248.6(increasing)-255.4(freque)-8.6(ncy)-247.4([21])-250.9(and)-247.4(would)-254.8(rather)]TJ
0 -1.0755 TD
[(enh)-8.4(ance)-749.7(the)-750.5(negati)-10.1(ve)-747.4(freque)-8.6(ncy-dep)-7.7(endence)-758.1(of)]TJ
/F5 1 Tf
21.3794 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 528.378 411.534 Tm
(rs)Tj
9.963 0 0 9.963 533.99 411.534 Tm
(.)Tj
-22.5516 -1.0698 TD
[(Moreo)-7.8(ver)24.2(,)]TJ
/F5 1 Tf
4.598 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 361.134 400.875 Tm
(w)Tj
9.963 0 0 9.963 371.452 400.875 Tm
[(is)-466(in)-464.8(the)-466(order)-468.3(of)-469.8(only)-466.4(1)-461.7(hPa)]TJ
/F9 1 Tf
12.559 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(L)Tj
7.472 0 0 6.641 505.304 405.298 Tm
(-1)Tj
/F9 1 Tf
9.963 0 0 9.963 511.483 402.86 Tm
(.)Tj
/F3 1 Tf
0.2732 -0.1992 TD
(s)Tj
7.472 0 0 6.641 518.003 405.298 Tm
(-1)Tj
9.963 0 0 9.963 528.775 400.875 Tm
(in)Tj
-22.0281 -1.0755 TD
[(norm)-7.8(al)-288.8(subje)-7.8(cts)-285.1([8,)-288(21])-288.4(and)-287.2(is)-289.6(not)-289.2(subst)-8.6(antially)-289.6(incre)-8.6(ased)]TJ
0 -1.0698 TD
[(in)-521.8(COPD)-527(patients)-527.4([8].)-518(More)-524.8(probabl)-9.7(y)61.8(,)-518.2(the)-517.2(low)-8.6(er)-515.7(fre-)]TJ
0 -1.0755 TD
[(que)-8.4(ncy)-247.4(dependen)-7.3(ce)-247(of)-247.8(FOT)-214.4(resi)-8.6(stance)-248.4(in)-248.6(this)-248(study)-252.1(is)-244.1(due)]TJ
0 -1.0698 TD
[(to)-356.7(the)-357.9(applic)-10.1(ation)-356.1(of)-355.9(the)-357.9(pressure)-359.6(input)-361.4(around)-359.4(the)-357.9(head)]TJ
0 -1.0755 TD
[(rathe)-8.6(r)-611.3(than)-614.7(at)-613.2(the)-614(mout)-8.6(h;)-612.8(this)-612.2(min)-7.8(imizes)-617.7(trans)-9.4(mural)]TJ
0 -1.0698 TD
[(press)-8.2(ure)-442.5(swings)-445.7(across)-447.5(extra)-8.6(thora)-8.2(cic)-443.7(airway)-445.8(walls,)-447(and)]TJ
0 -1.0755 TD
[(the)-278.2(correspondi)-10.3(ng)-269(loss)-275.3(of)-264.9(flow)-272.7(throu)-7.8(gh)-269(that)-275.7(paral)-8.6(lel)-269.2(pa)-7.6(th-)]TJ
0 -1.0698 TD
[(way)-308.2([17].)-308.2(The)-302.7(head)-305.5(generat)-10.5(or)-299(techni)-10.1(que)-304.3(has)-305.5(been)-305.5(shown)]TJ
0 -1.0755 TD
[(to)-316.9(decreas)-9.7(e)-308.5(subst)-8.6(antially)-318(the)-312.4(negati)-10.1(ve)-309.2(freque)-8.6(ncy-dep)-7.7(end-)]TJ
0 -1.0698 TD
[(enc)-8.8(e)-456.4(o)0(f)]TJ
/F5 1 Tf
3.5566 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 350.759 294.009 Tm
(rs)Tj
9.963 0 0 9.963 360.964 294.009 Tm
[(in)-459.2(obstr)-9(uctive)-459.7(p)-6.5(atients)-464([22].)-461.9(Uppe)-7.4(r)-457.6(airway)]TJ
-5.1841 -1.0755 TD
[(shunt)-7.4(ing)-380.2(may)-375.7(simil)-9.6(arly)-377.3(explai)-10.1(n,)-371(at)-379.9(least)-380.5(in)-373.8(part,)-383.4(the)-375(ob-)]TJ
0 -1.0698 TD
[(servat)-10.6(ion)-346.1(that)-349.6(the)-352.2(increase)-354.3(in)]TJ
/F5 1 Tf
12.0583 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 435.515 272.636 Tm
(rs)Tj
9.963 0 0 9.963 444.586 272.636 Tm
[(after)-351.6(induced)-350(broncho)-7.3(-)]TJ
-13.5776 -1.0755 TD
[(con)-8.4(striction)-264.3(in)-254.3(norm)-7.8(al)-254.7(subjects)-264.4(is)-255.5(less)-258.6(than)-256.2(the)-255.5(incre)-8.6(ase)-254.7(in)]TJ
/F5 1 Tf
0 -1.0698 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 315.383 251.263 Tm
(L,sb)Tj
9.963 0 0 9.963 333.241 251.263 Tm
[([13].)-410.7(The)-410.8(presen)-8.2(t)-407.2(observ)-7.8(ations,)-415.3(therefore,)-414(sugges)-7.4(t)]TJ
-2.4014 -1.0755 TD
[(that)-8.2(,)-478.4(provided)-482.8(the)-483.1(upper)-478.1(airway)-485.6(artef)-10.2(act)-477.8(is)-477.4(elim)-11.4(inated,)]TJ
T*
[(FOT)-544.5(does)-539.6(not)-539.6(underes)-8.9(timate)-544.9(the)-540(level)-544.3(of)-543.7(airway)-542.5(ob-)]TJ
0 -1.0698 TD
[(stru)-8.2(ction)-475.6(up)-473.8(to)-470.5(resistanc)-11.1(e)-473.5(values)-475.6(of)-469.8(10\26115)-476.1(hPa)]TJ
/F9 1 Tf
19.7803 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(L)Tj
7.472 0 0 6.641 515.112 223.597 Tm
(-1)Tj
/F9 1 Tf
9.963 0 0 9.963 521.291 221.159 Tm
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(s)Tj
7.472 0 0 6.641 527.811 223.597 Tm
(-1)Tj
9.963 0 0 9.963 533.99 219.175 Tm
(,)Tj
-22.5516 -1.0755 TD
[(dep)-8.4(ending)-337.4(on)-331.6(the)-340.8(oscillation)-346.7(freque)-8.6(ncy)59.9(.)]TJ
1.0015 -1.0471 TD
[(An)11.6(ot)18.8(he)20.8(r)-531.6(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nc)15.1(e)-524.7(b)0(e)15.1(t)0(w)20.6(e)0(e)14.7(n)-530(th)18.9(is)-517.3(st)17.7(ud)15.5(y)-530(a)0(n)20.8(d)-530(pr)19.6(ev)15.1(io)18.8(us)]TJ
-1.0015 -1.0755 TD
[(re)13.5(po)21.2(rt)17.3(s)-218.2(i)0(n)-214.5(w)12.4(hi)13.2(ch)-206.8(F)11.4(O)0(T)]TJ
/F5 1 Tf
8.57 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 400.592 187.313 Tm
(rs)Tj
9.963 0 0 9.963 408.359 187.313 Tm
-0.0155 Tc
[(h)-15.5(a)5.3(s)-233.7(b)-15.5(ee)-15.5(n)-222.3(c)-15.5(om)-15.5(pa)-15.5(re)-15.5(d)-222.3(t)-15.5(o)]TJ
/F5 1 Tf
8.6269 0 TD
0 Tc
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 500.258 187.313 Tm
0.0001 Tc
[(L,)21.9(s)15.2(b)]TJ
9.963 0 0 9.963 516.019 187.313 Tm
0 Tc
[(is)-210(th)18.9(e)]TJ
-20.7477 -1.0698 TD
[(me)12(th)18.8(od)-280.4(us)20(ed)-280.8(to)-282.7(co)20.8(mp)18.1(ut)13.2(e)]TJ
/F5 1 Tf
10.0097 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 414.992 176.655 Tm
[(L,)21.8(s)15.1(b)]TJ
9.963 0 0 9.963 428.485 176.655 Tm
0.2906 Tc
(.G)Tj
6.974 0 0 6.974 440.901 176.655 Tm
0.0001 Tc
[(RIM)19.7(B)0(Y)]TJ
/F5 1 Tf
9.963 0 0 9.963 465.505 176.655 Tm
0 Tc
[(et)-277.5(al)]TJ
/F3 1 Tf
1.7356 0 TD
[(.)-290.6([)0(8)19.6(])-304(obtained)]TJ
-17.4131 -1.0755 TD
[(the)-232.7(resisti)-11.2(ve)-223.9(compo)-7.4(nent)-233.5(of)]TJ
/F5 1 Tf
10.6527 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 421.512 165.94 Tm
(tp)Tj
9.963 0 0 9.963 429.902 165.94 Tm
[(by)-223.5(subtr)-9(acting)-232.1(analog)-7.8(ically)]TJ
-12.1038 -1.0698 TD
[(from)-413.4(it)-410.3(a)-410.9(signal)-409.3(propor)-7.8(tion)-7.8(al)-408.3(to)-407.9(volume,)-414.9(and)-406.7(compu)-7.4(ted)]TJ
0 -1.0755 TD
[(inspi)-9.8(ratory)-608.1(resistanc)-11.1(e)-604.4(i)0(n)-601.4(the)-608.3(0\2610.5)-600.9(L)]TJ
/F9 1 Tf
16.036 0.2049 TD
(.)Tj
/F3 1 Tf
0.2675 -0.2049 TD
(s)Tj
7.472 0 0 6.641 475.597 148.989 Tm
(-1)Tj
9.963 0 0 9.963 487.786 144.567 Tm
[(flow)-602.8(range;)]TJ
-17.9138 -1.0698 TD
(N)Tj
6.974 0 0 6.974 316.516 133.909 Tm
0.0001 Tc
(AGELS)Tj
/F5 1 Tf
9.963 0 0 9.963 342.765 133.909 Tm
0 Tc
[(et)-391.3(a)-6.5(l)]TJ
/F3 1 Tf
1.8722 0 TD
[(.)-393([15])-398.9(and)-395.3(P)]TJ
6.974 0 0 6.974 411.931 133.909 Tm
0.0001 Tc
(HAGOO)Tj
/F5 1 Tf
9.963 0 0 9.963 440.957 133.909 Tm
0 Tc
[(et)-391.3(al)]TJ
/F3 1 Tf
1.8722 0 TD
[(.)-393([13])-398.9(used)-397.3(an)-394.6(iso-)]TJ
-15.0856 -1.0755 TD
[(volum)-9.3(e)-501.9(method)-505.6(which)-505.6(provi)-7.8(des)-499(a)-501.9(mean)-502.1(v)-6.5(alue)-501.3(for)-500.6(in-)]TJ
0 -1.0698 TD
[(spir)-8.2(atory)-315.5(and)-315.7(expir)-8.2(atory)]TJ
/F5 1 Tf
9.9641 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 414.595 112.535 Tm
(L)Tj
9.963 0 0 9.963 422.532 112.535 Tm
[(at)-311.6(the)-312.4(selec)-8.6(ted)-312.4(volum)-9.3(e\(s\).)-315.5(In)]TJ
ET
0 0 0 0 k
0 0 0 1 K
0 J 0 j 0.586 w 3.864 M [72 ]0 d
/GS3 gs
1 i 
175.069 497.931 4.147 -4.147 re
B
167.99 495.364 4.147 -4.147 re
B
169.309 501.082 4.147 -4.147 re
B
170.726 493.663 4.147 -4.147 re
B
178.476 492.264 m
178.476 493.479 179.46 494.464 180.675 494.464 c
181.89 494.464 182.874 493.479 182.874 492.264 c
182.874 491.049 181.89 490.065 180.675 490.065 c
179.46 490.065 178.476 491.049 178.476 492.264 c
b
178.329 495.93 m
178.329 497.144 179.314 498.129 180.528 498.129 c
181.743 498.129 182.728 497.144 182.728 495.93 c
182.728 494.715 181.743 493.73 180.528 493.73 c
179.314 493.73 178.329 494.715 178.329 495.93 c
b
179.502 492.557 m
179.502 493.772 180.487 494.757 181.701 494.757 c
182.916 494.757 183.9 493.772 183.9 492.557 c
183.9 491.343 182.916 490.358 181.701 490.358 c
180.487 490.358 179.502 491.343 179.502 492.557 c
b
190.352 500.915 m
190.352 502.129 191.336 503.114 192.551 503.114 c
193.765 503.114 194.75 502.129 194.75 500.915 c
194.75 499.7 193.765 498.715 192.551 498.715 c
191.336 498.715 190.352 499.7 190.352 500.915 c
b
195.554 500.935 4.147 -4.147 re
B
167.333 485.373 m
167.333 486.588 168.318 487.572 169.532 487.572 c
170.747 487.572 171.731 486.588 171.731 485.373 c
171.731 484.159 170.747 483.174 169.532 483.174 c
168.318 483.174 167.333 484.159 167.333 485.373 c
b
157.07 488.452 m
157.07 489.667 158.054 490.651 159.269 490.651 c
160.484 490.651 161.468 489.667 161.468 488.452 c
161.468 487.238 160.484 486.253 159.269 486.253 c
158.054 486.253 157.07 487.238 157.07 488.452 c
b
150.191 491.892 4.147 -4.147 re
B
153.375 492.1 4.147 -4.147 re
B
163.937 496.39 4.147 -4.147 re
B
164.272 497.521 m
160.125 497.522 l
160.125 501.668 l
164.272 501.668 l
164.272 497.521 l
b
150.742 485.687 4.147 -4.147 re
B
154.847 480.849 4.147 -4.147 re
B
151.85 478.629 m
151.85 479.843 152.834 480.828 154.049 480.828 c
155.264 480.828 156.248 479.843 156.248 478.629 c
156.248 477.414 155.264 476.43 154.049 476.43 c
152.834 476.43 151.85 477.414 151.85 478.629 c
b
148.396 478.063 4.147 -4.147 re
B
222.167 481.033 m
224.757 476.547 l
219.577 476.547 l
222.167 481.033 l
b
207.799 510.959 m
207.799 512.174 208.783 513.158 209.998 513.158 c
211.213 513.158 212.197 512.174 212.197 510.959 c
212.197 509.744 211.213 508.76 209.998 508.76 c
208.783 508.76 207.799 509.744 207.799 510.959 c
b
191.595 515.45 4.147 -4.147 re
B
169.744 508.277 4.147 -4.147 re
B
3.864 M []0 d
108.296 592.632 m
108.296 443.084 l
283.942 443.084 l
S
3.864 M [2 2 ]0 d
108.296 443.084 m
284.822 591.459 l
S
[72 ]0 d
108.296 443.084 m
106.448 443.084 104.884 443.084 103.605 443.084 c
108.59 472.407 m
106.741 472.407 105.177 472.407 103.898 472.407 c
108.296 502.024 m
106.448 502.024 104.884 502.024 103.605 502.024 c
108.003 531.64 m
106.154 531.64 104.591 531.64 103.312 531.64 c
108.296 561.55 m
106.448 561.55 104.884 561.55 103.605 561.55 c
108.319 592.411 m
106.47 592.411 104.906 592.411 103.627 592.411 c
108.296 443.084 m
108.296 437.953 l
143.338 443.084 m
143.338 437.953 l
178.379 443.084 m
178.379 437.953 l
213.42 443.084 m
213.42 437.953 l
249.194 443.084 m
249.194 437.953 l
283.942 443.084 m
283.942 437.953 l
S
170.412 528.331 m
170.412 529.546 171.396 530.531 172.611 530.531 c
173.826 530.531 174.81 529.546 174.81 528.331 c
174.81 527.117 173.826 526.132 172.611 526.132 c
171.396 526.132 170.412 527.117 170.412 528.331 c
b
170.558 523.64 m
170.558 524.854 171.543 525.839 172.758 525.839 c
173.972 525.839 174.957 524.854 174.957 523.64 c
174.957 522.425 173.972 521.441 172.758 521.441 c
171.543 521.441 170.558 522.425 170.558 523.64 c
b
163.961 511.764 m
163.961 512.978 164.945 513.963 166.16 513.963 c
167.375 513.963 168.359 512.978 168.359 511.764 c
168.359 510.549 167.375 509.565 166.16 509.565 c
164.945 509.565 163.961 510.549 163.961 511.764 c
b
167.55 510.172 4.147 -4.147 re
B
169.239 506.632 m
169.239 507.847 170.224 508.832 171.438 508.832 c
172.653 508.832 173.637 507.847 173.637 506.632 c
173.637 505.418 172.653 504.433 171.438 504.433 c
170.224 504.433 169.239 505.418 169.239 506.632 c
b
184.487 515.723 m
184.487 516.937 185.471 517.922 186.686 517.922 c
187.901 517.922 188.885 516.937 188.885 515.723 c
188.885 514.508 187.901 513.523 186.686 513.523 c
185.471 513.523 184.487 514.508 184.487 515.723 c
b
191.964 519.535 m
191.964 520.749 192.949 521.734 194.164 521.734 c
195.378 521.734 196.363 520.749 196.363 519.535 c
196.363 518.32 195.378 517.335 194.164 517.335 c
192.949 517.335 191.964 518.32 191.964 519.535 c
b
192.768 516.77 4.147 -4.147 re
B
189.249 517.503 4.147 -4.147 re
B
199.002 515.43 m
199.002 516.644 199.986 517.629 201.201 517.629 c
202.416 517.629 203.4 516.644 203.4 515.43 c
203.4 514.215 202.416 513.23 201.201 513.23 c
199.986 513.23 199.002 514.215 199.002 515.43 c
b
204.28 513.963 m
204.28 515.178 205.265 516.162 206.479 516.162 c
207.694 516.162 208.678 515.178 208.678 513.963 c
208.678 512.749 207.694 511.764 206.479 511.764 c
205.265 511.764 204.28 512.749 204.28 513.963 c
b
212.051 513.817 m
212.051 515.031 213.035 516.016 214.25 516.016 c
215.464 516.016 216.449 515.031 216.449 513.817 c
216.449 512.602 215.464 511.617 214.25 511.617 c
213.035 511.617 212.051 512.602 212.051 513.817 c
b
207.359 508.685 m
207.359 509.9 208.343 510.884 209.558 510.884 c
210.773 510.884 211.757 509.9 211.757 508.685 c
211.757 507.47 210.773 506.486 209.558 506.486 c
208.343 506.486 207.359 507.47 207.359 508.685 c
b
240.787 484.405 m
243.377 479.919 l
238.198 479.919 l
240.787 484.405 l
b
237.21 487.631 m
239.8 483.145 l
234.621 483.145 l
237.21 487.631 l
b
229.644 482.645 m
232.234 478.16 l
227.055 478.16 l
229.644 482.645 l
b
223.047 479.273 m
225.636 474.788 l
220.457 474.788 l
223.047 479.273 l
b
226.712 486.311 m
229.302 481.826 l
224.122 481.826 l
226.712 486.311 l
b
217.627 485.578 m
220.217 481.092 l
215.038 481.092 l
217.627 485.578 l
b
213.486 483.965 m
216.076 479.48 l
210.897 479.48 l
213.486 483.965 l
b
241.484 502.381 m
238.62 506.527 l
244.349 506.527 l
241.484 502.381 l
b
237.526 491.677 m
234.661 495.824 l
240.39 495.824 l
237.526 491.677 l
b
257.466 496.663 m
254.601 500.809 l
260.33 500.809 l
257.466 496.663 l
b
251.465 494.024 m
248.601 498.17 l
254.33 498.17 l
251.465 494.024 l
b
244.107 494.464 m
241.242 498.61 l
246.971 498.61 l
244.107 494.464 l
b
253.402 494.024 m
250.537 498.17 l
256.266 498.17 l
253.402 494.024 l
b
267.582 496.076 m
264.717 500.223 l
270.447 500.223 l
267.582 496.076 l
b
274.033 495.93 m
271.168 500.076 l
276.898 500.076 l
274.033 495.93 l
b
205.23 501.375 4.147 -4.147 re
B
145.757 481.582 4.147 -4.147 re
B
150.889 476.744 4.147 -4.147 re
B
150.179 478.482 m
150.179 479.697 151.163 480.682 152.378 480.682 c
153.593 480.682 154.577 479.697 154.577 478.482 c
154.577 477.268 153.593 476.283 152.378 476.283 c
151.163 476.283 150.179 477.268 150.179 478.482 c
b
155.518 480.225 m
155.518 481.44 156.503 482.424 157.717 482.424 c
158.932 482.424 159.916 481.44 159.916 480.225 c
159.916 479.01 158.932 478.026 157.717 478.026 c
156.503 478.026 155.518 479.01 155.518 480.225 c
b
152.18 485.247 4.147 -4.147 re
B
190.645 506.632 m
190.645 507.847 191.629 508.832 192.844 508.832 c
194.059 508.832 195.043 507.847 195.043 506.632 c
195.043 505.418 194.059 504.433 192.844 504.433 c
191.629 504.433 190.645 505.418 190.645 506.632 c
b
187.126 508.099 m
187.126 509.313 188.111 510.298 189.325 510.298 c
190.54 510.298 191.524 509.313 191.524 508.099 c
191.524 506.884 190.54 505.899 189.325 505.899 c
188.111 505.899 187.126 506.884 187.126 508.099 c
b
188.152 497.396 m
188.152 498.611 189.137 499.595 190.352 499.595 c
191.566 499.595 192.551 498.611 192.551 497.396 c
192.551 496.181 191.566 495.196 190.352 495.196 c
189.137 495.196 188.152 496.181 188.152 497.396 c
b
191.378 500.621 m
191.378 501.836 192.362 502.821 193.577 502.821 c
194.792 502.821 195.776 501.836 195.776 500.621 c
195.776 499.406 194.792 498.422 193.577 498.422 c
192.362 498.422 191.378 499.406 191.378 500.621 c
b
180.675 489.038 m
180.675 490.253 181.66 491.238 182.874 491.238 c
184.089 491.238 185.073 490.253 185.073 489.038 c
185.073 487.824 184.089 486.84 182.874 486.84 c
181.66 486.84 180.675 487.824 180.675 489.038 c
b
170.119 484.053 m
170.119 485.268 171.103 486.253 172.318 486.253 c
173.532 486.253 174.517 485.268 174.517 484.053 c
174.517 482.839 173.532 481.854 172.318 481.854 c
171.103 481.854 170.119 482.839 170.119 484.053 c
b
164.401 486.693 m
164.401 487.907 165.385 488.892 166.6 488.892 c
167.814 488.892 168.799 487.907 168.799 486.693 c
168.799 485.478 167.814 484.494 166.6 484.494 c
165.385 484.494 164.401 485.478 164.401 486.693 c
b
167.626 500.328 m
167.626 501.543 168.611 502.527 169.825 502.527 c
171.04 502.527 172.025 501.543 172.025 500.328 c
172.025 499.113 171.04 498.129 169.825 498.129 c
168.611 498.129 167.626 499.113 167.626 500.328 c
b
160.295 498.715 m
160.295 499.93 161.28 500.914 162.495 500.914 c
163.709 500.914 164.694 499.93 164.694 498.715 c
164.694 497.501 163.709 496.516 162.495 496.516 c
161.28 496.516 160.295 497.501 160.295 498.715 c
b
161.468 494.317 m
161.468 495.531 162.453 496.516 163.667 496.516 c
164.882 496.516 165.867 495.531 165.867 494.317 c
165.867 493.102 164.882 492.118 163.667 492.118 c
162.453 492.118 161.468 493.102 161.468 494.317 c
b
154.114 497.27 4.147 -4.147 re
B
155.897 491.238 m
155.897 492.453 156.881 493.437 158.096 493.437 c
159.311 493.437 160.295 492.453 160.295 491.238 c
160.295 490.023 159.311 489.038 158.096 489.038 c
156.881 489.038 155.897 490.023 155.897 491.238 c
b
154.736 489.4 4.147 -4.147 re
B
166.893 491.091 m
166.893 492.306 167.878 493.29 169.092 493.29 c
170.307 493.29 171.292 492.306 171.292 491.091 c
171.292 489.877 170.307 488.892 169.092 488.892 c
167.878 488.892 166.893 489.877 166.893 491.091 c
b
168.959 487.843 m
168.959 489.058 169.944 490.042 171.159 490.042 c
172.373 490.042 173.358 489.058 173.358 487.843 c
173.358 486.629 172.373 485.644 171.159 485.644 c
169.944 485.644 168.959 486.629 168.959 487.843 c
b
164.694 489.038 m
164.694 490.253 165.678 491.238 166.893 491.238 c
168.108 491.238 169.092 490.253 169.092 489.038 c
169.092 487.824 168.108 486.84 166.893 486.84 c
165.678 486.84 164.694 487.824 164.694 489.038 c
b
162.055 482.242 m
162.055 483.456 163.039 484.441 164.254 484.441 c
165.469 484.441 166.453 483.456 166.453 482.242 c
166.453 481.027 165.469 480.042 164.254 480.042 c
163.039 480.042 162.055 481.027 162.055 482.242 c
b
161.322 484.934 m
161.322 486.148 162.306 487.132 163.521 487.132 c
164.735 487.132 165.72 486.148 165.72 484.934 c
165.72 483.719 164.735 482.734 163.521 482.734 c
162.306 482.734 161.322 483.719 161.322 484.934 c
b
159.114 482.587 m
159.114 483.802 160.099 484.787 161.313 484.787 c
162.528 484.787 163.513 483.802 163.513 482.587 c
163.513 481.373 162.528 480.388 161.313 480.388 c
160.099 480.388 159.114 481.373 159.114 482.587 c
b
159.562 485.52 m
159.562 486.735 160.547 487.719 161.761 487.719 c
162.976 487.719 163.961 486.735 163.961 485.52 c
163.961 484.305 162.976 483.321 161.761 483.321 c
160.547 483.321 159.562 484.305 159.562 485.52 c
b
164.694 483.589 m
164.694 484.803 165.678 485.788 166.893 485.788 c
168.108 485.788 169.092 484.803 169.092 483.589 c
169.092 482.374 168.108 481.39 166.893 481.39 c
165.678 481.39 164.694 482.374 164.694 483.589 c
b
195.26 499.469 4.147 -4.147 re
B
186.833 493.29 m
186.833 494.505 187.817 495.49 189.032 495.49 c
190.247 495.49 191.231 494.505 191.231 493.29 c
191.231 492.076 190.247 491.091 189.032 491.091 c
187.817 491.091 186.833 492.076 186.833 493.29 c
b
184.264 500.935 4.147 -4.147 re
B
176.13 497.639 m
176.13 498.854 177.114 499.838 178.329 499.838 c
179.543 499.838 180.528 498.854 180.528 497.639 c
180.528 496.424 179.543 495.44 178.329 495.44 c
177.114 495.44 176.13 496.424 176.13 497.639 c
b
178.329 501.501 m
178.329 502.715 179.314 503.7 180.528 503.7 c
181.743 503.7 182.728 502.715 182.728 501.501 c
182.728 500.286 181.743 499.302 180.528 499.302 c
179.314 499.302 178.329 500.286 178.329 501.501 c
b
0.591 w 
193.286 715.213 4.147 -4.147 re
179.149 696.168 m
179.149 697.383 180.134 698.368 181.348 698.368 c
182.563 698.368 183.548 697.383 183.548 696.168 c
183.548 694.954 182.563 693.97 181.348 693.97 c
180.134 693.97 179.149 694.954 179.149 696.168 c
s
183.602 693.788 4.147 -4.147 re
B
177.714 697.013 4.147 -4.147 re
B
150.739 663.294 4.147 -4.147 re
S
3.864 M []0 d
108.264 772.662 m
108.264 623.123 l
283.899 623.123 l
S
3.864 M [2 2 ]0 d
108.264 623.123 m
284.779 771.489 l
S
[72 ]0 d
212.941 722.376 m
212.941 723.59 213.926 724.575 215.14 724.575 c
216.355 724.575 217.34 723.59 217.34 722.376 c
217.34 721.162 216.355 720.177 215.14 720.177 c
213.926 720.177 212.941 721.162 212.941 722.376 c
h
205.318 721.203 m
205.318 722.418 206.302 723.402 207.517 723.402 c
208.731 723.402 209.716 722.418 209.716 721.203 c
209.716 719.989 208.731 719.004 207.517 719.004 c
206.302 719.004 205.318 719.989 205.318 721.203 c
h
200.04 719.151 m
200.04 720.365 201.025 721.35 202.239 721.35 c
203.454 721.35 204.438 720.365 204.438 719.151 c
204.438 717.936 203.454 716.951 202.239 716.951 c
201.025 716.951 200.04 717.936 200.04 719.151 c
h
209.13 712.993 m
209.13 714.208 210.114 715.192 211.329 715.192 c
212.543 715.192 213.528 714.208 213.528 712.993 c
213.528 711.779 212.543 710.794 211.329 710.794 c
210.114 710.794 209.13 711.779 209.13 712.993 c
h
208.543 705.076 m
208.543 706.291 209.528 707.276 210.742 707.276 c
211.957 707.276 212.941 706.291 212.941 705.076 c
212.941 703.862 211.957 702.877 210.742 702.877 c
209.528 702.877 208.543 703.862 208.543 705.076 c
h
192.123 698.626 m
192.123 699.84 193.108 700.825 194.322 700.825 c
195.537 700.825 196.521 699.84 196.521 698.626 c
196.521 697.411 195.537 696.427 194.322 696.427 c
193.108 696.427 192.123 697.411 192.123 698.626 c
h
171.305 706.227 m
171.305 707.442 172.29 708.426 173.504 708.426 c
174.719 708.426 175.703 707.442 175.703 706.227 c
175.703 705.013 174.719 704.028 173.504 704.028 c
172.29 704.028 171.305 705.013 171.305 706.227 c
s
170.719 703.295 m
170.719 704.51 171.703 705.494 172.918 705.494 c
174.132 705.494 175.117 704.51 175.117 703.295 c
175.117 702.081 174.132 701.096 172.918 701.096 c
171.703 701.096 170.719 702.081 170.719 703.295 c
b
165.734 703.588 m
165.734 704.803 166.719 705.787 167.933 705.787 c
169.148 705.787 170.132 704.803 170.132 703.588 c
170.132 702.374 169.148 701.389 167.933 701.389 c
166.719 701.389 165.734 702.374 165.734 703.588 c
h
166.32 696.844 m
166.32 698.059 167.305 699.043 168.52 699.043 c
169.734 699.043 170.719 698.059 170.719 696.844 c
170.719 695.63 169.734 694.645 168.52 694.645 c
167.305 694.645 166.32 695.63 166.32 696.844 c
s
167.493 693.619 m
167.493 694.833 168.478 695.818 169.692 695.818 c
170.907 695.818 171.892 694.833 171.892 693.619 c
171.892 692.404 170.907 691.42 169.692 691.42 c
168.478 691.42 167.493 692.404 167.493 693.619 c
b
157.524 696.134 m
157.524 697.348 158.509 698.333 159.723 698.333 c
160.938 698.333 161.922 697.348 161.922 696.134 c
161.922 694.919 160.938 693.934 159.723 693.934 c
158.509 693.934 157.524 694.919 157.524 696.134 c
h
178.049 678.541 m
178.049 679.755 179.034 680.74 180.248 680.74 c
181.463 680.74 182.447 679.755 182.447 678.541 c
182.447 677.326 181.463 676.342 180.248 676.342 c
179.034 676.342 178.049 677.326 178.049 678.541 c
h
181.274 672.97 m
181.274 674.184 182.259 675.169 183.474 675.169 c
184.688 675.169 185.673 674.184 185.673 672.97 c
185.673 671.755 184.688 670.77 183.474 670.77 c
182.259 670.77 181.274 671.755 181.274 672.97 c
h
164.561 666.226 m
164.561 667.44 165.546 668.425 166.76 668.425 c
167.975 668.425 168.959 667.44 168.959 666.226 c
168.959 665.011 167.975 664.027 166.76 664.027 c
165.546 664.027 164.561 665.011 164.561 666.226 c
h
161.629 670.038 m
161.629 671.252 162.614 672.237 163.828 672.237 c
165.043 672.237 166.027 671.252 166.027 670.038 c
166.027 668.823 165.043 667.838 163.828 667.838 c
162.614 667.838 161.629 668.823 161.629 670.038 c
h
161.629 687.923 m
161.629 689.138 162.614 690.123 163.828 690.123 c
165.043 690.123 166.027 689.138 166.027 687.923 c
166.027 686.709 165.043 685.724 163.828 685.724 c
162.614 685.724 161.629 686.709 161.629 687.923 c
s
180.143 695.761 m
180.143 696.976 181.128 697.96 182.342 697.96 c
183.557 697.96 184.541 696.976 184.541 695.761 c
184.541 694.546 183.557 693.562 182.342 693.562 c
181.128 693.562 180.143 694.546 180.143 695.761 c
b
165.441 686.164 m
165.441 687.379 166.425 688.363 167.64 688.363 c
168.854 688.363 169.839 687.379 169.839 686.164 c
169.839 684.95 168.854 683.965 167.64 683.965 c
166.425 683.965 165.441 684.95 165.441 686.164 c
h
171.598 682.059 m
171.598 683.274 172.583 684.258 173.797 684.258 c
175.012 684.258 175.997 683.274 175.997 682.059 c
175.997 680.845 175.012 679.86 173.797 679.86 c
172.583 679.86 171.598 680.845 171.598 682.059 c
h
237.478 708.621 m
234.639 703.704 l
231.8 708.621 l
237.478 708.621 l
h
258.589 709.794 m
255.75 704.877 l
252.911 709.794 l
258.589 709.794 l
h
253.018 706.276 m
250.179 701.358 l
247.341 706.276 l
253.018 706.276 l
h
246.274 698.652 m
243.435 693.735 l
240.596 698.652 l
246.274 698.652 l
h
249.5 693.667 m
246.661 688.75 l
243.822 693.667 l
249.5 693.667 l
h
264.16 694.254 m
261.321 689.337 l
258.482 694.254 l
264.16 694.254 l
h
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[(substa)-9.7(ntial)-369.9(\(fig)-8.6(.)-364.6(2b\).)-374.2(The)-371(author)-9(s)-366.2(were)-9.4(,)-364.6(there)-8.6(fore,)-371.2(reluc)-8.6(-)]TJ
25.1977 66.1185 TD
[(tant)-309.8(to)-311.2(postulat)-9.1(e)-302.8(that)-309.8(the)-306.7(resi)-8.6(stance)-311(was)-309.4(the)-306.7(same)-309.8(in)-305.5(both)]TJ
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(R)Tj
/F3 1 Tf
7.97 0 0 7.97 315.383 750.727 Tm
(L,ex)Tj
9.963 0 0 9.963 332.617 750.727 Tm
[(an)-7.6(d)]TJ
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(R)Tj
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7.97 0 0 7.97 356.031 750.727 Tm
(L,in)Tj
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[(,)-307.7(although)-312.9(signifi)-9.6(cant)-307.8(in)-305.5(all)-309.1(pati)-8.2(ents)-308.6(\(table)]TJ
-5.9865 -1.0527 TD
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[(is)-357.9(maximum)-364.7(at)]TJ
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(rs)Tj
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(X)Tj
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9.963 0 0 9.963 466.583 551.962 Tm
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T*
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(L,0)Tj
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[(was)-326.5(compu)-7.4(ted)-323.7(using)-326.1(the)-323.7(values)-327.6(of)]TJ
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(E)Tj
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(L)Tj
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(P)Tj
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(L)Tj
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[(could)-541.5(either)-541(decreas)-9.8(e)-536.1(durin)-7.8(g)]TJ
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T*
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(E)Tj
/F3 1 Tf
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(L)Tj
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[(durin)-7.8(g)-592.6(the)-591.2(respi)-9.4(ratory)]TJ
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(R)Tj
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(L,0)Tj
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0 Tc
[(could)-262.7(a)-6.9(s)-258(well)-268.2(be)-258(exagger)-8.2(ated)]TJ
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(i.e.)Tj
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T*
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(')Tj
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[(s)-411.7(equation)-415.7(\()]TJ
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(P)Tj
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(=)Tj
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(K)Tj
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(1)Tj
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(6)Tj
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(')Tj
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(\)+)Tj
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(K)Tj
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(2)Tj
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(6)Tj
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(V)Tj
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(')Tj
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(2)Tj
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[(\)\),)-551.4(where)]TJ
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(P)Tj
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(1)Tj
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(and)Tj
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(K)Tj
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(2)Tj
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(are)Tj
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(dP/dV)Tj
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(')Tj
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(=)Tj
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(K)Tj
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(1)Tj
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0.3997 Tc
[(+\()399.7(2)]TJ
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(6)Tj
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(K)Tj
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(2)Tj
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(6)Tj
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(')Tj
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(P/V)Tj
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(1)Tj
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(2)Tj
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(6)Tj
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(L,0)Tj
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[(proxi)-7.8(mal)-338.3(airway)-343.3(walls)-338.5([29].)]TJ
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ET
0 0 0 1 K
0 J 0 j 0.617 w 3.864 M []0 d
/GS3 gs
1 i 
106.671 775.331 m
106.671 679.014 l
106.98 670.37 m
275.534 670.37 l
S
154.83 761.747 m
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159.769 760.383 158.663 759.278 157.299 759.278 c
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b
148.346 766.687 m
148.346 768.051 149.452 769.156 150.816 769.156 c
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b
140.629 765.452 m
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144.462 767.921 145.568 766.816 145.568 765.452 c
145.568 764.088 144.462 762.982 143.099 762.982 c
141.735 762.982 140.629 764.088 140.629 765.452 c
b
133.528 763.908 m
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134.634 761.439 133.528 762.544 133.528 763.908 c
b
126.119 761.747 m
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131.059 760.383 129.953 759.278 128.589 759.278 c
127.225 759.278 126.119 760.383 126.119 761.747 c
b
118.402 759.278 m
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122.235 761.747 123.341 760.641 123.341 759.278 c
123.341 757.914 122.235 756.808 120.871 756.808 c
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b
111.61 752.177 m
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116.55 750.813 115.444 749.708 114.08 749.708 c
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b
103.892 739.52 m
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108.832 738.156 107.726 737.051 106.362 737.051 c
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b
162.238 742.299 m
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b
169.03 716.058 m
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b
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b
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b
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b
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b
206.384 700.623 m
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b
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b
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b
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b
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b
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b
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b
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b
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b
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b
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134.146 763.908 l
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S
3.864 M [1.9 1.9 ]0 d
106.362 727.481 m
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S
[]0 d
106.362 679.322 m
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S
3.864 M 
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S
0 0 0 0 k
3.864 M 
119.392 623.227 4.193 -4.193 re
B
112.755 612.114 4.193 -4.193 re
B
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S
127.11 633.569 4.193 -4.193 re
B
134.673 638.971 4.193 -4.193 re
B
142.237 635.421 4.193 -4.193 re
B
149.183 623.073 4.193 -4.193 re
B
156.283 605.939 4.193 -4.193 re
B
163.229 591.584 4.193 -4.193 re
B
170.792 594.98 4.193 -4.193 re
B
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B
185.302 620.14 4.193 -4.193 re
B
192.711 638.354 4.193 -4.193 re
B
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B
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B
214.938 639.434 4.193 -4.193 re
B
222.347 636.965 4.193 -4.193 re
B
233.949 632.308 m
229.756 632.308 l
229.756 636.502 l
233.949 636.501 l
233.949 632.308 l
b
244.419 628.475 4.193 -4.193 re
B
251.674 624.771 4.193 -4.193 re
B
237.01 633.878 4.193 -4.193 re
B
259.392 625.851 4.193 -4.193 re
B
266.492 623.536 4.193 -4.193 re
B
273.901 605.322 4.193 -4.193 re
B
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106.776 581.566 m
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107.029 630.188 m
101.472 630.188 l
106.953 654.984 m
101.396 654.984 l
S
105.037 607.637 4.193 -4.193 re
B
110.233 599.851 m
104.961 599.851 l
107.597 604.418 l
110.233 599.851 l
b
108.832 602.299 m
111.919 602.917 l
116.395 604.615 l
120.1 604.46 l
124.113 604.923 l
127.354 604.923 l
130.441 605.232 l
134.918 605.232 l
138.622 604.923 l
142.327 603.997 l
147.112 602.454 l
149.581 600.602 l
154.07 598.616 l
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159.923 597.977 l
162.547 598.44 l
166.715 600.293 l
169.647 601.836 l
174.587 603.071 l
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181.378 604.152 l
184.62 606.004 l
188.479 609.4 l
192.183 613.259 l
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203.451 621.439 l
207.001 622.057 l
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215.028 620.822 l
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222.745 620.668 l
225.987 621.902 l
230.309 622.983 l
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240.959 620.205 l
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252.381 613.413 l
255.468 612.795 l
260.099 612.178 l
263.495 611.869 l
267.662 611.098 l
270.132 608.782 l
275.38 598.286 l
S
117.488 602.784 m
112.215 602.784 l
114.852 607.35 l
117.488 602.784 l
b
124.743 603.092 m
119.47 603.092 l
122.106 607.659 l
124.743 603.092 l
b
131.534 602.938 m
126.261 602.938 l
128.898 607.505 l
131.534 602.938 l
b
139.252 603.401 m
133.979 603.401 l
136.616 607.967 l
139.252 603.401 l
b
146.815 602.321 m
141.542 602.321 l
144.179 606.887 l
146.815 602.321 l
b
154.07 598.616 m
148.797 598.616 l
151.434 603.183 l
154.07 598.616 l
b
161.17 595.838 m
155.897 595.838 l
158.534 600.404 l
161.17 595.838 l
b
168.116 598.153 m
162.843 598.153 l
165.48 602.72 l
168.116 598.153 l
b
175.217 601.395 m
169.944 601.395 l
172.58 605.961 l
175.217 601.395 l
b
204.544 619.608 m
199.271 619.608 l
201.908 624.175 l
204.544 619.608 l
b
211.953 620.38 m
206.68 620.38 l
209.316 624.947 l
211.953 620.38 l
b
219.208 618.682 m
213.935 618.682 l
216.571 623.249 l
219.208 618.682 l
b
227.388 619.3 m
222.115 619.3 l
224.752 623.866 l
227.388 619.3 l
b
234.952 621.461 m
229.679 621.461 l
232.315 626.027 l
234.952 621.461 l
b
241.743 619.3 m
236.47 619.3 l
239.107 623.866 l
241.743 619.3 l
b
249.307 614.515 m
244.034 614.515 l
246.67 619.081 l
249.307 614.515 l
b
256.407 610.965 m
251.134 610.965 l
253.771 615.531 l
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b
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0 -1.0528 TD
[(most)-328.4(prom)-7.8(inent,)-333.7(substantial)-334.1(differences)-331.3(were)-328.1(also)-331.4(obser-)]TJ
T*
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0 -1.0471 TD
(8-Hz)Tj
/F5 1 Tf
2.2421 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 86.627 729.808 Tm
(rs)Tj
9.963 0 0 9.963 94.847 729.808 Tm
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-3.6704 -1.0527 TD
[(as)-270.6(great)-276.1(as)-270.6(that)-275.7(of)]TJ
/F5 1 Tf
7.2725 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 136.8 719.319 Tm
0.0001 Tc
(L,0)Tj
9.963 0 0 9.963 150.236 719.319 Tm
0 Tc
[(even)-271.3(du)-7.2(ring)-268.8(the)-278.2(inspiratory)-282.1(phase,)]TJ
-9.2301 -1.0471 TD
[(as)-481.1(illustrated)-490.5(in)-476.2(figure)-482.9(2a.)-480.3(The)-479.1(author)-9(s)-474.3(have)-481.9(no)-479.5(satis-)]TJ
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0 -1.0471 TD
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0 -1.0527 TD
[(tissue)-285.3(resistanc)-11.1(e)-280([30])-279.4(have)-282.7(been)-277(de)-7.6(monstrated)-286.6(in)-277.1(subje)-7.8(cts)]TJ
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0 -1.0528 TD
[(to)-504.7(the)-511.5(incre)-8.6(ased)-505.8(acti)-8.6(vity)-508.6(of)-503.9(respi)-9.4(ratory)-511.3(musc)-7.8(les,)-507.4(these)]TJ
0 -1.0471 TD
[(varia)-8.6(tions)-487.8(did)-494.1(not)-488.4(reach)-490.3(the)-494.5(levels)-495(seen)-488.7(in)-487.6(this)-492.7(study)55.2(.)]TJ
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[(Unfortu)-9.2(natel)-9.4(y)61.8(,)-376(in)-379.5(these)-383.8(severe)-8.6(ly)-385.2(obstructed)-385.9(pati)-8.2(ents,)-383(the)]TJ
T*
[(signa)-7.8(l/noise)-412.4(ratio)-414.6(of)-407.2(the)-409.1(high)-409.5(freque)-8.6(ncy)-412.4(compo)-7.4(nents)-411.8(of)]TJ
0 -1.0471 TD
[(the)-312.4(oesopha)-7.3(geal)-313.5(press)-8.2(ure)-311.6(signa)-7.8(l)-304.7(was)-315.1(not)-312(good)-316(enough)-312.3(to)]TJ
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0 -1.0527 TD
[(dependen)-7.3(ce)-343.8(of)]TJ
/F5 1 Tf
6.2027 0 TD
(R)Tj
/F3 1 Tf
7.97 0 0 7.97 126.085 583.313 Tm
(rs)Tj
9.963 0 0 9.963 135.156 583.313 Tm
[(could)-342.3(be)-343.4(locat)-9.4(ed)-343.4(in)-339.7(the)-346.5(chest)-343.9(wal)-9(l.)-339.3(A)]TJ
-7.7164 -1.0471 TD
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[(three)-446.8(patients,)-448.1(was)-440.3(the)-443.2(increasing)-448.9(discrepancy)-447.7(betw)-9.8(een)]TJ
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0 -1.0471 TD
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7.97 0 0 7.97 64.29 551.962 Tm
(rs)Tj
9.963 0 0 9.963 73.531 551.962 Tm
(and)Tj
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1.7982 0 TD
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7.97 0 0 7.97 97.512 551.962 Tm
0.0001 Tc
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9.963 0 0 9.963 111.855 551.962 Tm
0 Tc
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[(These)-266(patients)-265.6(wer)-8.2(e)-257.2(among)-269.1(those)-263.9(in)-260(whom)-266.2(the)-261.2(exp)-8.4(iratory)]TJ
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[(flow)-272.7(pattern)-274.3(clear)-9(ly)-265.7(sugges)-7.4(ted)-272.5(expiratory)-278.2(flow-lim)-12.1(itation)-9.6(,)]TJ
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[(as)-338.9(descri)-10.5(bed)-338.4(above.)-340.7(The)-342.6(authors)-346.7(therefore,)-345.7(hypoth)-7(esize)-8.6(d)]TJ
T*
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[(infinit)-10.8(e)-490.6(impedance)-503.4(for)-489.2(the)-494.5(forced)-498(oscillat)-11.9(ion)-494.1(signal.)-495(It)]TJ
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18.6707 0 TD
(R)Tj
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7.97 0 0 7.97 250.299 468.227 Tm
0.0001 Tc
(L,0)Tj
9.963 0 0 9.963 263.622 468.227 Tm
0 Tc
[(is)-261.2(not)]TJ
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1.0015 -1.0471 TD
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20.6453 0 TD
(R)Tj
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7.97 0 0 7.97 279.893 436.875 Tm
(rs)Tj
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T*
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[(compu)-7.4(ting)-235.4(the)-232.7(coh)-8.4(erence)-235.4(funct)-8.2(ion)-232.3(\()]TJ
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14.0443 0 TD
(c)Tj
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(2)Tj
9.963 0 0 9.963 206.929 363.628 Tm
[(\))-235.7([16].)-234.2(A)-164(value)-234.6(of)]TJ
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7.0051 0 TD
(c)Tj
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7.472 0 0 6.641 281.707 368.05 Tm
(2)Tj
9.963 0 0 9.963 58.28 353.14 Tm
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(rs)Tj
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7.472 0 0 6.641 172.403 315.723 Tm
(2)Tj
9.963 0 0 9.963 176.088 311.301 Tm
[(.)-393(The)-388.1(data)-393.2(were,)-391(there)-8.6(fore,)]TJ
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18.8642 0 TD
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7.472 0 0 6.641 251.206 294.803 Tm
(2)Tj
9.963 0 0 9.963 257.272 290.381 Tm
[(at)-231.9(8)-228.4(H)0(z)]TJ
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T*
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0 -1.0471 TD
[(value)-302.9(of)]TJ
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3.5737 0 TD
(c)Tj
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7.472 0 0 6.641 98.872 252.964 Tm
(2)Tj
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[(may)-301.7(be)-303.5(close)-304.1(to)-299.8(1)-302.4(\(above)-302.9(the)-301(usual)-303.7(thres)-9.4(hold)]TJ
-4.7459 -1.0528 TD
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0 -1.0527 TD
[(an)15.1(ce)-634(da)15.1(ta)-636(fr)12.4(ee)20.4(d)-649.5(f)0(r)18(o)0(m)-636.3(t)0(h)13.2(e)-644.2(up)15.5(pe)20.8(r)-651.1(a)0(i)18.4(r)0(w)15.7(a)0(y)-639.3(a)0(r)19.2(t)0(e)18.4(f)0(a)13.5(c)0(t)-636(a)0(n)15.1(d)]TJ
T*
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0 -1.0471 TD
[(of)-230.7(ai)18.4(rw)15.7(ay)-229.6(ob)21.2(st)17.7(ru)13.9(ct)18.5(io)18.9(n,)-228.8(wa)16.9(s)-241(o)0(b)21.2(s)0(e)19.6(r)0(v)13.9(e)0(d)20.8(.)-239.4(Th)17.1(is)-227(fu)13.9(rt)17.3(he)20.8(r)-241.4(v)0(a)20.8(l)0(i)16.5(d)0(a)15.1(t)0(e)18.4(s)]TJ
0 -1.0528 TD
[(th)18.9(e)-268.6(u)0(s)20(e)-268.6(of)-259.2(t)13.9(h)0(e)-258(f)0(o)13.9(r)0(c)19.2(e)0(d)-258(o)0(s)20(c)0(i)12.8(l)0(l)22.2(a)0(t)12.8(i)0(o)18.9(n)-262.5(te)12.8(ch)20.8(ni)18.9(qu)15.5(e)-268.6(f)0(o)19.6(r)-264.1(a)-268.6(n)0(u)15.5(m)0(b)18.1(e)0(r)-259.6(o)0(f)]TJ
0 -1.0471 TD
[(cl)18.4(in)18.9(ic)12.8(al)-323(ap)20.8(pl)13.2(ic)18.4(at)18.4(io)18.9(ns)-327.1(in)-322.6(pa)20.8(ti)16.5(en)15.1(ts)17.7(,)-330.4(i)0(n)18.9(c)0(l)12.8(u)0(d)21.2(i)0(n)18.9(g)-336.5(t)13.9(h)0(e)-326.3(e)0(x)15.1(p)0(l)18.9(o)0(r)19.6(a)0(t)18.4(i)0(o)13.2(n)]TJ
25.1977 66.1583 TD
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