%PDF-1.2 % 2 0 obj << /Length 18503 >> stream 0 g /GS2 gs 1 i 391.011 659.055 0.51 -288.907 re f BT /F1 1 Tf 14.944 0 0 14.944 94.11 732.812 Tm 0.0209 Tc [(Periodic)-333.8(bre)3.8(a)0.1(thing)-332.5(d)-2.4(uring)-332.5(s)0.1(lee)3.8(p)-336.3(in)-332.5(patients)-333.8(affected)-332.5(by)]TJ 7.8795 -1.0357 TD [(fibromyalgia)-333.8(syndrome)]TJ /F2 1 Tf 10.959 0 0 10.959 72.454 686.494 Tm 0 Tc [(M.)-334.5(Sergi)]TJ /F3 1 Tf 8.219 0 0 7.305 113.726 691.37 Tm 0 Tw (+)Tj /F2 1 Tf 10.959 0 0 10.959 118.375 686.494 Tm [(,)-329.4(M)0(.)-334.5(Rizzi)]TJ /F3 1 Tf 8.219 0 0 7.305 164.523 691.37 Tm (+)Tj /F2 1 Tf 10.959 0 0 10.959 169.172 686.494 Tm [(,)-329.4(A)0(.)-336(Braghiroli)]TJ /F3 1 Tf 6.0836 0 TD (**)Tj /F2 1 Tf 0.9984 0 TD [(,)-334.6(P)0(.)-330.8(Sarzi)-333.1(Puttini)]TJ /F3 1 Tf 7.2631 0 TD (*)Tj /F2 1 Tf 0.4966 0 TD [(,)-334.6(M)0(.)-334.5(Greco)]TJ /F3 1 Tf 4.7748 0 TD (*)Tj /F2 1 Tf 0.5018 0 TD [(,)-334.6(M)0(.)-329.3(Cazzola)]TJ /F3 1 Tf 5.6491 0 TD (*)Tj /F2 1 Tf 0.5018 0 TD [(,)-329.4(A)0(.)-336(Andreoli)]TJ /F3 1 Tf 8.219 0 0 7.305 517.663 691.37 Tm (+)Tj /F4 1 Tf 8.966 0 0 8.966 58.28 649.587 Tm [(Periodic)-327.4(br)31.4(eathing)-323.4(during)-323(sleep)-323.1(in)-323.9(patients)-326.5(affected)-324.9(by)-321.2(fibr)27.7(omyalgia)-326.2(syndr)32(ome.)-320.6(M.)-325.3(Ser)32.2(gi,)]TJ 0 -1.0559 TD [(M.)-483.4(Rizzi,)-478.9(A.)-480.1(Braghir)26.9(oli,)-480.4(P)123.5(.)-477.1(Sarzi)-482.8(Puttini,)-486.6(M.)-477.1(Gr)28.1(eco,)-481.5(M.)-477.1(Cazzola,)-483(A.)-480.1(Andr)29(eoli.)]TJ /F5 1 Tf 33.2901 0 TD (#)Tj /F4 1 Tf 1.0053 0 TD (ERS)Tj -34.2955 -1.0496 TD [(Journals)-335.6(Ltd)-334.6(1999.)]TJ /F6 1 Tf 0 -1.0559 TD [(ABSTRACT)66.7(:)-582.2(Seventeen)-591.9(patients)-592.7(affected)-584.8(by)-591.9(fibr)13(omyalgia)-589.2(syndrome)-576(\(FMS\))-588.7(\(16)]TJ 0 -1.0875 TD [(females)-462.5(and)-463.5(one)-458.4(male\))-462.6(and)-457.2(17)-460.6(matched)-462.5(healthy)-458.3(subjects)-464.8(underwent)-461.2(formal)-462.1(poly-)]TJ 0 -1.0812 TD [(somnography)52.7(,)-331.7(a)-334.6(sleep)-334.3(questionnaire)-329(and)-330.8(lung)-332.6(function)-337.2(tests.)]TJ 0.999 -1.0559 TD [(FMS)-328.6(patients)-333.5(slept)-335.5(significantly)-331.8(less)-331.3(efficiently)-337.5(than)-331.2(the)-332.9(healthy)-331.8(controls)-321.1(\(p)]TJ /F7 1 Tf 32.1267 0 TD (<)Tj /F6 1 Tf 0.5501 0 TD (0.01\),)Tj -33.6758 -1.0812 TD [(had)-318.1(a)-315.7(higher)-318.5(propor)12.7(tion)-322.4(of)-316.1(stage)-321.9(1)-315.7(sleep)-315.3(\(mean\213)]TJ 6.276 0 0 6.276 244.176 582.633 Tm 0.0001 Tc (SD)Tj 8.966 0 0 8.966 252.113 582.633 Tm 0 Tc [(,)-319.1(21\2136%)]TJ /F8 1 Tf 3.9265 0 TD (versus)Tj /F6 1 Tf 2.9022 0 TD [(1)51.1(1\2134%;)-317.3(p)]TJ /F7 1 Tf 4.1794 0 TD (<)Tj /F6 1 Tf 0.5501 0 TD (0.001\),)Tj -33.1763 -1.0812 TD [(less)-268.1(slow)-270.4(wave)-266.6(sleep)-264.7(\(p)]TJ /F7 1 Tf 9.5286 0 TD (<)Tj /F6 1 Tf 0.5564 0 TD [(0.01\))-267.4(and)-261.2(twice)-269.2(as)-265.7(many)-268.9(arousals)-258.3(per)-268.5(hour)-254.1(of)-265.5(sleep)-271.1(\(p)]TJ /F7 1 Tf 22.5412 0 TD (<)Tj /F6 1 Tf 0.5501 0 TD (0.001\).)Tj -33.1763 -1.0812 TD [(The)-520(respiratory)-515.1(pattern)-526.2(of)-518.4(FMS)-524.6(patients)-523.2(showed)-523.2(a)-524.3(high)-516(occurrence)-515.3(of)-524.8(periodic)]TJ T* [(breath)11.7(ing)-467.3(\(PB\))-463.3(\(15\2138%)-462.3(of)-467.8(total)-463.3(sleep)-467.1(time\))-463.6(in)-467.9(15/17)-461.4(patients,)]TJ /F8 1 Tf 27.7133 0 TD (versus)Tj /F6 1 Tf 3.0413 0 TD [(2/17)-468.3(control)]TJ -30.7546 -1.0812 TD [(subjects.)-442.4(The)-437.8(short)-440.6(length)-439.8(of)-442.6(apnoeas)-437.2(and)-438.2(hypopnoeas)-439.1(did)-440.6(not)-440.6(affect)-442(the)-440.4(apnoea/)]TJ T* [(hypopnoea)-242.4(index)-237.1(\(5.1\2133.5)]TJ /F8 1 Tf 11.0461 0 TD (versus)Tj /F6 1 Tf 2.82 0 TD (3.2\2131.6;)Tj 6.276 0 0 6.276 214.923 534.16 Tm 0.0001 Tc (NS)Tj 8.966 0 0 8.966 222.916 534.16 Tm 0 Tc [(\),)-237.3(but)-243.2(FMS)-240.1(patients)-245(had)-242.2(a)-239.8(greater)-230.4(number)]TJ -18.3617 -1.0812 TD [(of)-335.1(desaturations)-336.8(per)-331.7(hour)-323.7(of)-335.1(sleep)-334.3(\(8\2135)]TJ /F8 1 Tf 17.0971 0 TD (versus)Tj /F6 1 Tf 2.9212 0 TD [(3\2133;)-331(p)]TJ /F7 1 Tf 2.7441 0 TD (<)Tj /F6 1 Tf 0.5564 0 TD (0.01\).)Tj -22.3199 -1.0559 TD [(Pulmonary)-251.6(volumes)-251.7(did)-250.9(not)-250.9(differ)-258.6(between)-250.1(the)-250.7(two)-255.7(gr)13.9(oups,)-252.1(but)-249.5(FMS)-252.7(patients)-251.3(had)-254.9(a)]TJ -0.999 -1.0875 TD [(lower)-413.7(transfer)-420.6(factor)-409.4(of)-410.9(the)-415.1(lung)-414.8(for)-410.2(carbon)-411(monoxide)-419.3(\()]TJ /F8 1 Tf 24.6973 0 TD (T)Tj /F6 1 Tf 7.173 0 0 7.173 285.109 505.247 Tm (L,CO)Tj 8.966 0 0 8.966 306.142 505.247 Tm (\(5.8+1)Tj /F8 1 Tf 3.0476 0 TD (versus)Tj /F6 1 Tf 2.9971 0 TD (7.7+1)Tj -33.6885 -1.0812 TD (mmol)Tj /F9 1 Tf 2.4154 0.2213 TD (.)Tj /F6 1 Tf 0.2719 -0.2213 TD (min)Tj 6.725 0 0 5.977 97.115 499.578 Tm (-1)Tj /F9 1 Tf 8.966 0 0 8.966 102.671 497.537 Tm (.)Tj /F6 1 Tf 0.2719 -0.2213 TD (kPa)Tj 6.725 0 0 5.977 119.962 499.578 Tm (-1)Tj 8.966 0 0 8.966 125.518 495.553 Tm 0.3103 Tc (;p)Tj /F7 1 Tf 1.1887 0 TD 0 Tc (=)Tj /F6 1 Tf 0.5501 0 TD [(0.001\).)-314(PB)-310.7(occurrence)-306.6(correlated)-305.5(with)]TJ /F8 1 Tf 16.5028 0 TD (T)Tj /F6 1 Tf 7.173 0 0 7.173 294.463 495.553 Tm -0.0001 Tc [(L,)-8.9(CO)]TJ 8.966 0 0 8.966 314.589 495.553 Tm 0 Tc (\(r)Tj /F7 1 Tf 0.7588 0 TD (=)Tj /F6 1 Tf 0.5185 0 TD [(-0.62;)-318.4(p)]TJ /F7 1 Tf 3.2626 0 TD (=)Tj /F6 1 Tf 0.5501 0 TD (0.01\),)Tj -33.6758 -1.0812 TD [(number)-435.3(of)-442.6(desaturations)-450.6(\(r)]TJ /F7 1 Tf 11.9756 0 TD (=)Tj /F6 1 Tf 0.5564 0 TD [(0.76,)-440.6(p)]TJ /F7 1 Tf 2.9907 0 TD (=)Tj /F6 1 Tf 0.5564 0 TD [(0.001\))-443.9(and)-444.6(carbon)-442.6(dioxide)-447.1(tension)-446.8(in)-442.6(arterial)]TJ -16.0792 -1.0812 TD [(blood)-294.2(\()]TJ /F8 1 Tf 2.9907 0 TD (P)Tj /F6 1 Tf 7.173 0 0 7.173 90.482 476.164 Tm (a,CO)Tj 6.725 0 0 5.977 106.583 474.69 Tm (2)Tj 8.966 0 0 8.966 109.928 476.164 Tm 0.2976 Tc [(\)\()297.6(r)]TJ /F7 1 Tf 1.3784 0 TD 0 Tc (=)Tj /F6 1 Tf 0.5185 0 TD [(-0.50;)-293.1(p)]TJ /F7 1 Tf 3.2437 0 TD (=)Tj /F6 1 Tf 0.5501 0 TD [(0.05\).)-289.3(Stepwise)-297.6(multiple)-298.6(linear)-290.7(regr)15.4(ession)-290.9(analysis)-292.5(showed)]TJ -11.4508 -1.0812 TD [(desaturation)-216(frequency)-206.2(\(p)]TJ /F7 1 Tf 10.8564 0 TD (=)Tj /F6 1 Tf 0.5501 0 TD [(0.0001\))-215.8(and)]TJ /F8 1 Tf 5.1089 0 TD (T)Tj /F6 1 Tf 7.173 0 0 7.173 211.748 466.469 Tm (L,CO)Tj 8.966 0 0 8.966 230.967 466.469 Tm (\(p)Tj /F7 1 Tf 0.8726 0 TD (=)Tj /F6 1 Tf 0.5564 0 TD [(0.029\))-210(to)-221.3(be)-212.3(the)-219.1(best)-213.5(pred)11.6(ictors)-222.3(of)-214.9(PB)]TJ -20.6886 -1.0812 TD [(perce)11.2(ntage)-338.2(\(R)]TJ 6.725 0 0 5.977 111.855 460.743 Tm (2)Tj 8.966 0 0 8.966 118.261 456.775 Tm [(0.73;)-330.6(p)]TJ /F7 1 Tf 2.9528 0 TD (=)Tj /F6 1 Tf 0.5564 0 TD (0.0001\).)Tj -9.1998 -1.0559 TD [(Patients)-306.8(complaining)-301(of)-303.5(daytime)-308.4(hypersomnolence)-299.4(had)-305.5(a)-303(higher)-299.5(number)-296.2(of)-297.1(tender)]TJ -0.999 -1.0812 TD [(points,)-317.7(about)-324.4(twice)-319.8(as)-316.3(many)-319.5(arousals)-315.2(per)-319.1(hour)-317.4(and)-318.1(a)-322(lower)-318.8(sleep)-321.6(efficiency)-321.7(than)-318.6(pa-)]TJ T* [(tients)-241.1(who)-240.6(did)-238.3(not)-238.3(report)-229.8(this)-241.4(symptom.)]TJ /F8 1 Tf 16.8442 0 TD (T)Tj /F6 1 Tf 7.173 0 0 7.173 214.753 427.918 Tm -0.0001 Tc (L,CO)Tj 8.966 0 0 8.966 234.142 427.918 Tm 0 Tc [(was)-236.9(more)-231.9(impaired)-231.8(and)-235.9(the)-238.1(occurrence)]TJ -19.6137 -1.0875 TD [(of)-335.1(PB)-329.7(was)-338.1(higher)86.2(.)]TJ 0.999 -1.0496 TD [(The)-216.5(occurr)11.7(ence)-217.2(of)-214.9(periodic)-212.2(breathing)-202.7(in)-214.9(fibromyalgia)-209.5(syndrom)11.3(e)-214.3(patients,)-216.2(which)-215.1(was)]TJ -0.999 -1.0875 TD [(previou)10.8(sly)-305.6(unre)11.6(ported,)-307.3(and)-305.5(is)-299.7(shown)-308.9(to)-303.5(be)-300.8(linked)-307.1(to)-303.5(a)-303(r)13.4(eduction)-310.7(of)-303.5(transfer)-306.8(factor)-295.6(of)]TJ 0 -1.0812 TD [(the)-219.1(lung)-212.5(for)-207.9(carbon)-215(monoxide)-217(could)-218.1(play)-220.2(a)-214.5(major)-220(r)13.4(ole)-215.6(in)-221.3(the)-212.8(symptoms)-220.1(of)-214.9(poor)-217.6(sleep)-220.5(of)]TJ T* [(these)-332.9(patients.)]TJ /F4 1 Tf 0 -1.0559 TD [(Eur)-331.9(Respir)-333.8(J)-334.4(1999;)-333.5(14:)-334.6(203\261208.)]TJ /F3 1 Tf 5.977 0 0 5.313 401.499 654.123 Tm (+)Tj 7.97 0 0 7.97 404.844 650.608 Tm [(Servizio)-538.7(di)-545.9(Fisiopa)12(tologia)-539.2(Respiratoria)7.7(,)]TJ -0.4197 -1.0599 TD [(*Servizio)-429.9(di)-439.2(Reumatolo)11.2(gia,)-435(Azienda)-428.1(Os-)]TJ 0 -1.067 TD [(pedaliera)-444.3(\261)-446(Polo)-439.9(Universitario)-439.5(L.)-447.7(Sacco,)]TJ 0 -1.0599 TD [(Milano,)-280.8(Italy)63.5(.)-283.5(**Fondazione)-277.7("S.)-278.6(Maugeri")]TJ T* [(IRCCS)-371.5(Div)-382.7(Pneumolog)12.4(ia)-381.3(Centro)-377.8(Medico)]TJ 0 -1.067 TD [(V)106.3(eruno,)-329(Italy)63.5(.)]TJ 0 -2.1268 TD [(Corresponde)11.8(nce:)-333.4(M.)-330.3(Ser)16.5(gi)]TJ 0 -1.0599 TD [(Azienda)-200.5(Ospedalicra-P)10.6(olo)-209.5(Universitario)-204.7(L.)]TJ T* (Sacco)Tj 0 -1.067 TD [(V)56.5(i)0(a)-331.5(G.B.)-335.2(Grassi)-328.1(74)]TJ 0 -1.0599 TD [(20157)-323.8(Milano)]TJ T* (Italy)Tj 0 -1.067 TD [(Fax:)-325.1(39)-330.1(023560042)]TJ 0 -2.1268 TD [(Keywords)11.5(:)-334.6(Fibromyalg)11.9(ia)]TJ 0 -1.0599 TD [(periodic)-327.5(breathing)]TJ T* [(polysomn)13(ography)]TJ 0 -1.067 TD (sleep)Tj 0 -2.1197 TD [(Received:)-327.9(June)-326.1(30)-330.1(1998)]TJ 0 -1.067 TD [(Accepted)-325.4(after)-331.6(revision)-329.8(March)-321.1(15)-330.1(1999)]TJ 9.963 0 0 9.963 68.258 343.956 Tm [(Fi)19.6(br)13.9(om)18.1(ya)15.1(lg)18.9(ia)-277.5(sy)20(nd)15.5(ro)19.6(me)-278.2(\(F)14.7(MS)14.4(\))-286.9(i)13.9(s)-286.5(a)-291.4(co)20.8(mm)14.9(on)-280.4(rh)19.6(eu)15.1(m)13.2(a)0(t)12.8(i)0(c)]TJ -1.0015 -1.0584 TD [(di)18.9(so)14.4(rd)19.6(er)-214.1(ch)20.8(ar)13.5(ac)20.4(te)12.8(ri)17.3(ze)20.4(d)-222.7(b)0(y)-212.1(g)0(e)20.8(n)0(e)15.1(r)0(a)19.2(l)0(i)16.5(z)0(e)14.7(d)-222.7(mu)18.1(sc)19.6(ul)18.9(os)14.4(ke)20.8(le)12.8(t)13.9(a)0(l)-214.9(p)0(a)15.1(i)0(n)]TJ 0 -1.0528 TD [(an)15.1(d)-598.3(d)0(i)13.2(f)20.4(fu)19.6(se)-594.9(te)18.4(nd)15.5(er)19.2(ne)15.1(ss)-590(at)-596.1(di)18.9(sc)13.9(re)19.2(te)-596.1(an)20.8(at)18.4(om)12.4(ic)-590.4(lo)13.2(ca)20.4(ti)16.5(on)15.5(s,)]TJ 0 -1.0584 TD [(te)18.4(rm)16.5(ed)-320.6(te)18.4(nd)15.5(er)-316.5(po)15.5(in)18.9(ts)-318.1(\(T)15.5(P\))-321([1)19.6(].)-338.5(Eighty)-343.5(to)-339.7(90%)-340.4(o)-6.5(f)-338.1(patients)]TJ 0 -1.0527 TD [(are)-334.7(fema)-8.6(les,)-336.7(and)-338.4(the)-335.1(peak)-339.6(age)-333.2(is)-335.2(30\2615)-8.7(0)-330.8(yrs.)]TJ 1.0015 -1.0528 TD [(Th)17.1(e)-314.2(c)0(r)19.2(i)0(t)16.5(e)0(r)19.2(i)0(a)-305.9(u)0(s)14.4(e)0(d)-303.5(f)0(o)19.6(r)-315.3(di)18.9(ag)20.8(no)15.5(si)17.7(s)-314.9(o)0(f)-304.7(F)11.4(MS)-304.3(we)16.9(re)-305.1(pu)15.5(bl)18.9(is)17.7(he)15.1(d)]TJ -1.0015 -1.0584 TD [(by)-377.1(th)18.8(e)-382.4(A)0(m)14.2(e)0(r)13.5(i)13.9(ca)14.7(n)-382(C)0(o)16.5(l)0(l)16.5(e)0(g)15.1(e)-382.4(of)-378.7(R)11.6(h)0(e)15.1(u)0(m)18.1(a)0(t)18.4(o)0(l)13.2(o)0(g)21.2(y)-387.7(in)-373.8(19)15.5(90)-371.4([2)13.9(].)]TJ 0 -1.0528 TD [(The)-297(pain)-301.7(is)-295.3(wi)-7.8(despre)-8.2(ad,)-292.5(last)-9.4(ing)-294.9(for)-301.4(at)-300.2(least)-300.8(three)-298.8(mont)-8.6(hs,)]TJ 0 -1.0584 TD [(bilateral)-13.5(,)-284.9(above)-294.8(and)-292.9(below)-295.1(the)-289.6(waist)-292.9(axial)-9.4(,)-284.9(and)-292.9(in)-288.4(at)-288.8(least)]TJ 0 -1.0527 TD [(1)27.7(1)-342.2(out)-351.8(of)-344.6(18)-348.7(specified)-357.1(TP)103.3(.)-347.5(Synovitis)-350.2(o)-6.5(r)-343.8(myos)-7.4(itis)-347.1(are)-351.8(ab-)]TJ 0 -1.0584 TD [(sent.)-252.1(Other)-251.1(characteri)-11.9(stics)-250.4(of)-247.8(the)-244.1(syndro)-7.4(me,)-250.1(often)-247.2(presen)-8.2(t,)]TJ T* [(but)-385.9(not)-380.2(essent)-10.1(ial)-383(for)-386.7(the)-380.7(diagno)-7.4(sis,)-383(are;)-389.1(chronic)-385.7(fati)-9.8(gue,)]TJ 0 -1.0528 TD [(migraine)-10.7(,)-273.5(irritabl)-13.5(e)-268.6(b)0(o)-7.2(wel)-276.5(syndro)-7.4(me,)-272.9(headaches)-10.1(,)-273.5(paraes)-8.6(th-)]TJ 0 -1.0584 TD [(esias,)-305.7(Raynaud)]TJ /F10 1 Tf 6.0206 0 TD (')Tj /F3 1 Tf 0.2162 0 TD [(s)-297.9(like)-304.1(symp)-7.4(toms,)-306.1(depres)-8.2(sion,)-302.9(anxiety)-306.8(and)]TJ -6.2368 -1.0527 TD [(nonres)-7.8(torative)-448.1(and/or)-441.4(dist)-9(urbed)-444(sleep)-440.7([3].)-444(The)-439.3(report)-10.5(ed)]TJ 0 -1.0584 TD 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[(el)18.4(ec)14.7(tr)17.3(o-)19.6(oc)15.1(ul)18.9(og)15.5(ra)19.2(m)-260(\()0(E)15.5(O)12.4(G\))15.7(,)-262.1(a)0(n)20.8(d)-256.8(su)14.4(bm)18.1(en)15.1(t)13.9(a)0(l)-254.7(e)0(l)18.4(e)0(c)20.4(t)0(r)17.3(o)0(m)12.4(y)0(o)21.2(g)0(r)13.9(a)0(m)]TJ 0 -1.0471 TD [(\(C)14.9(hi)18.9(n\))-282(we)16.9(re)-288.1(re)19.2(co)15.1(rd)19.6(ed)-286.5(wi)14.9(t)13.9(h)-296.7(su)20(rf)18(ac)14.7(e)-291.4(e)0(l)18.4(e)0(c)14.7(t)0(r)17.3(o)0(d)15.5(e)0(s)-282(u)0(s)20(i)0(n)13.2(g)-291(st)17.7(an)15.1(d-)]TJ 0 -1.0528 TD [(ar)19.2(d)-308.1(t)0(e)18.4(c)0(h)15.1(n)0(i)18.9(q)0(u)15.5(e)0(s)-299([)0(1)19.6(3].)-310.8(Airflow)-322.8(and)-321.4(venti)-9(latory)-318.6(efforts)-315.7(wer)-8.2(e)]TJ 0 -1.0471 TD [(record)-8.6(ed)-519.8(respec)-8.6(tively)-524.3(by)-513.7(naso-o)-7.8(ral)-524.5(thermocoup)-9.9(les)-524.1(and)]TJ 0 -1.0527 TD [(thora)-8.2(cic)-449.3(and)-457.9(abdominal)-459.4(belts)-454(with)-455.6(buil)-7.8(t-on)-450.9(piezo)-456.6(elec-)]TJ 25.1977 12.4737 TD [(trode)-8.2(s.)-315.3(Oxyha)-8.1(emoglobi)-8.7(n)-313.7(saturati)-11.1(on)-314.5(was)-315.1(record)-8.6(ed)-314.9(by)-314.5(fin-)]TJ 0 -1.0528 TD [(ger)-465.2(pulse)-468.7(oximetry)-471.2(\(Pulsox-7;)-471.2(Minolta)-9.2(,)-461.3(Osaka,)-465.4(Japan\))-8.2(.)]TJ 0 -1.0471 TD [(The)-240.1(trans)-9.4(ducers)-241.5(and)-241.7(lead)-239.6(wires)-246.6(allowed)-242.5(norm)-7.8(al)-237.6(posit)-9.8(ional)]TJ 0 -1.0528 TD [(cha)-8.8(nges)-334.7(durin)-7.8(g)-330.8(sleep)-8.2(.)]TJ 1.0015 -1.0471 TD [(Be)16.1(dt)13.2(im)21.4(e)-490.6(a)0(n)15.1(d)-490.2(aw)16.9(ak)20.8(en)15.1(in)18.8(g)-490.2(t)0(i)16.5(m)13.2(e)-490.6(w)0(e)16.9(r)0(e)-481.5(a)0(t)-482.3(e)0(a)20.4(c)0(h)-479.9(s)0(u)14.4(b)0(j)18.8(e)0(c)20.4(t)]TJ /F10 1 Tf 21.203 0 TD 0 Tw (')Tj /F3 1 Tf 0.2106 0 TD (s)Tj -22.4151 -1.0527 TD [(di)13.2(sc)19.6(re)19.2(ti)16.5(on)15.5(;)-213.7(t)0(h)18.8(e)-217.4(po)15.5(ly)18.8(so)20(mn)12.4(og)21.2(ra)13.5(ph)21.2(y)-217(w)0(a)16.9(s)-218.2(te)18.4(rm)16.5(in)18.9(at)18.4(ed)-212.5(af)19.2(te)18.4(r)-218.6(f)0(i)17.3(n)0(a)20.8(l)]TJ 0 -1.0471 TD [(aw)16.9(ak)15.1(en)15.1(in)18.8(g.)-416.6(In)-418.5(or)13.9(de)20.8(r)-429.1(t)0(o)-419.3(a)0(v)15.1(o)0(i)18.9(d)-427.6(th)18.9(e)-428(f)0(i)17.3(r)0(s)18.4(t)-429.9(ni)18.9(gh)15.5(t)-424.2(e)0(f)24.9(f)0(e)19.2(c)0(t)-419.7(e)0(a)14.7(c)0(h)]TJ 0 -1.0528 TD [(su)14.4(bj)18.9(ec)14.7(t)-293.4(s)0(p)14.4(e)0(n)20.8(t)-299.1(tw)14.9(o)-296.7(n)0(i)18.9(g)0(h)15.5(t)0(s)-289.6(i)0(n)-288.4(t)0(h)18.9(e)-297.1(sl)17.7(ee)14.7(p)-296.7(l)0(a)18.4(b)0(o)15.5(r)0(a)19.2(t)0(o)18.9(r)0(y)76.5(,)-296.3(on)21.2(ly)-294.1(da)20.8(ta)]TJ 0 -1.0471 TD [(re)13.5(co)20.8(rd)14(ed)-314.9(du)21.2(ri)17.3(ng)-314.5(th)13.2(e)-319.8(s)0(e)14(c)0(o)20.8(n)0(d)-314.5(n)0(i)13.2(g)0(h)21.2(t)-327.5(w)12.4(e)0(r)13.5(e)-325.5(ev)20.8(al)18.4(ua)15.1(te)18.4(d.)]TJ /F4 1 Tf 0 -2.4811 TD [(Inter)-9.4(pr)31.4(etat)-8.2(ion)-334.7(of)-334(polys)-7.8(omno)-7(graphic)-339.4(data)]TJ /F3 1 Tf 1.0015 -1.8494 TD [(Sl)14(ee)20.4(p)-285.3(a)0(n)20.8(d)-285.3(br)19.6(ea)14.7(t)13.9(h)0(i)13.2(n)0(g)-269(v)0(a)15.1(r)0(i)17.3(a)0(b)20.8(l)0(e)12.8(s)-280.8(we)16.9(re)-271(st)17.7(or)13.9(ed)-269.4(on)-274.7(an)-269.4(op)15.5(ti)16.5(ca)20.4(l)]TJ -1.0015 -1.0527 TD [(di)13.2(sk)-230.3(an)15.1(d)-239.8(t)0(h)18.8(e)0(n)-235.2(m)0(a)17.7(n)0(u)15.5(a)0(l)18.5(l)0(y)-231.5(s)0(c)13.9(o)0(r)19.6(e)0(d)-235.2(b)0(y)-234.8(t)13.9(wo)-238.8(ph)21.2(ys)14.3(ic)18.5(ia)18.4(ns)20(,)-245.1(b)0(l)18.8(i)0(n)18.8(d)0(e)15.1(d)0(,)]TJ 0 -1.0471 TD [(in)-402.3(30)-405.6(s)-406(e)0(p)15.1(o)0(c)15.1(h)0(s)20(,)-410.1(ac)20.4(co)15.1(rd)19.6(in)13.2(g)-410.5(t)0(o)-402.3(s)0(t)17.7(a)0(n)20.8(d)0(a)15.1(r)0(d)-401.5(c)0(r)19.2(i)0(t)16.5(e)0(r)19.2(i)0(a)-402.7([)0(1)14(3].)-413.2(The)]TJ 0 -1.0527 TD [(correl)-11(ation)-430.1(between)-428.3(sleep)-8.2(,)-421.5(breat)-8.6(hing)-420.8(an)-7.6(d)-421.9(body)-424.2(position)]TJ 0 -1.0471 TD [(was)-337.9(analys)-9(ed)-337.7(automati)-11.5(cally)-339.4(by)-331.6(the)-335.1(compu)-7.4(ter)44.5(.)]TJ 1.0015 -1.0527 TD [(Ap)11.6(no)21.2(ea)14.7(s)-167(w)12.4(er)13.5(e)-166.2(d)0(e)15.1(f)0(i)17.3(n)0(e)20.8(d)-165.8(as)-162.5(10)21.2(-s)-158(pa)15.1(us)20(es)-156.8(in)-157.6(re)13.5(sp)20(ir)17.3(at)18.5(io)13.2(n.)-154.8(Hy)17.3(p-)]TJ -1.0015 -1.0471 TD [(op)15.5(no)15.5(ea)20.4(s)-383.2(w)0(e)16.9(r)0(e)-379.1(d)0(e)15.1(f)0(i)17.3(n)0(e)20.8(d)-387.7(as)-373(a)-388.1(d)0(e)20.8(c)0(r)19.2(e)0(m)12(e)0(n)20.8(t)-384.4(in)-379.5(ai)18.5(rf)18(lo)18.9(w)]TJ /F11 1 Tf 19.9283 0 TD ($)Tj /F3 1 Tf 0.8251 0 TD [(50)15.5(%,)]TJ -20.7534 -1.0528 TD [(as)13.9(so)20(ci)18.4(at)12.8(ed)-275.1(wi)14.9(th)-277.1(ei)12.8(th)18.9(er)-276.7(an)-280.8(ar)13.5(ou)21.2(sa)19.6(l)-293.4(a)0(t)-277.5(t)0(h)18.9(e)-291.4(en)20.8(d)-291(o)0(f)-276.3(t)0(h)18.8(e)-291.4(ep)20.8(is)17.7(od)15.5(e)]TJ 0 -1.0471 TD -0.0183 Tc [(o)-18.3(r)-414.1(a)-417.8(f)-18.3(a)-4.8(l)-4.4(l)-419.8(i)-18.3(n)-414.9(a)-18.3(rt)-18.3(er)-18.3(ia)-18.3(l)-415.3(o)-18.3(xy)-18.3(ge)-18.3(n)-407.2(s)-18.3(a)-4.3(t)-18.3(ur)-18.3(at)-18.3(io)-18.3(n)-412.5(\()]TJ /F4 1 Tf 15.8197 0 TD 0 Tc (S)Tj /F3 1 Tf 7.97 0 0 7.97 471.798 360.907 Tm [(a,)18.4(O)]TJ 7.472 0 0 6.641 482.74 359.263 Tm (2)Tj 9.963 0 0 9.963 486.368 360.907 Tm (\))Tj /F11 1 Tf 0.7227 0 TD ($)Tj /F3 1 Tf 0.8251 0 TD [(4%)13.2(.)-398.7(T)0(h)17.1(e)]TJ -19.3194 -1.0528 TD [(re)13.5(sp)20(ir)17.3(at)18.5(or)14(y)-456(d)0(i)13.2(s)0(t)17.7(u)0(r)19.6(b)0(a)15.1(n)0(c)20.8(e)-462.1(in)18.8(de)15.1(x)-456(\()0(R)14.9(D)0(I)15.7(\))-463.3(w)12.4(a)0(s)-452.7(d)0(e)15.1(f)0(i)17.3(n)0(e)20.8(d)-461.7(as)-452.7(th)18.9(e)]TJ 0 -1.0471 TD [(av)15.1(er)19.2(ag)15.1(e)-262.9(n)0(u)21.2(m)0(b)18.1(e)0(r)-253.9(o)0(f)-253.5(e)0(p)20.8(i)0(s)17.7(o)0(d)15.5(e)0(s)-253.5(o)0(f)-253.5(a)0(p)20.8(n)0(o)15.5(e)0(a)-252.7(a)0(n)20.8(d)-262.5(hy)21.2(po)15.5(pn)21.2(oe)15.1(a)-262.9(p)0(e)20.8(r)]TJ 0 -1.0527 TD [(ho)15.5(ur)-287.7(of)-287.7(sl)17.7(ee)14.7(p)-296.7(a)0(n)20.8(d)-302.4(t)13.9(h)0(e)-292.1(d)0(e)20.8(s)0(a)13.9(t)0(u)18.9(r)0(a)19.2(t)0(i)16.5(o)0(n)-291.7(e)0(v)20.8(e)0(n)15.1(t)-293.4(fr)12.4(eq)20.8(ue)15.1(nc)20.8(y)-296.7(\()0(D)15.7(E)0(F)17.9(\))]TJ 0 -1.0471 TD [(wa)16.9(s)-349.1(d)0(e)20.8(f)0(i)17.3(n)0(e)15.1(d)-342.2(as)-333.2(th)13.2(e)-342.6(n)0(u)21.2(m)0(b)12.4(e)0(r)-333.6(o)0(f)-333.2(e)0(p)15.1(i)0(s)17.7(o)0(d)21.2(e)0(s)-338.9(o)0(f)-333.2(a)-342.6(fa)13.5(ll)]TJ /F11 1 Tf 19.5584 0 TD ($)Tj /F3 1 Tf 0.8251 0 TD [(4%)-334(in)]TJ -20.3835 -1.0527 TD [(ox)15.5(yh)15.5(ae)20.4(mo)18.1(gl)13.2(ob)21.2(in)-510.4(sa)19.6(tu)18.9(ra)13.5(ti)16.5(on)-508(pe)20.8(r)-520.2(h)0(o)21.2(u)0(r)-509.6(o)0(f)-509.6(s)0(l)17.7(e)0(e)14.7(p)0(.)-507.6(P)11.4(er)13.5(io)18.8(di)18.8(c)]TJ 0 -1.0471 TD [(br)13.9(ea)20.4(th)13.2(i)13.9(n)0(g)-416.9(\()0(P)20.4(B)0(\))-411.9(w)0(a)16.9(s)-423.1(de)15.1(fi)17.3(ne)20.8(d)-421.9(a)0(s)-412.8(a)-422.3(se)19.6(ri)17.3(es)-412.8(of)-412.8(at)-408.3(le)12.8(as)19.6(t)-418.6(t)0(h)13.2(r)0(e)19.2(e)]TJ 0 -1.0528 TD [(su)14.4(cc)20.4(es)13.9(si)17.7(ve)-440.1(cy)20.8(cl)12.8(es)-441.3(of)-441.3(w)12.4(a)0(x)15.1(i)0(n)18.9(g)-450.3(an)15.1(d)-444.6(w)0(a)11.2(n)0(i)18.9(n)0(g)-439.7(i)0(n)-442.1(v)0(e)20.8(n)0(t)18.9(i)0(l)16.5(a)0(t)12.8(i)13.9(on)15.5(,)]TJ 0 -1.0471 TD [(wi)14.9(th)-436.4(ap)15.1(no)15.5(ea)20.4(s)-445.8(o)0(r)-441.3(h)0(y)21.2(p)0(o)15.5(p)0(n)21.2(o)0(e)15.1(a)0(s)19.6(.)-449.9(Ar)15.7(ou)21.2(sa)13.9(l)13.9(s)-451.5(w)12.4(e)0(r)13.5(e)-445(sc)13.9(or)19.6(ed)-440.1(ac)20.4(-)]TJ 0 -1.0528 TD [(co)15.1(rd)19.6(in)13.2(g)-586.9(t)0(o)-578.7(t)13.9(he)-582.4(Am)14.2(er)19.2(ic)18.4(an)-576.7(Sl)14(ee)20.4(p)-586.9(D)0(i)14.9(s)0(o)20(r)0(d)14(e)0(r)19.2(s)-588.1(As)16.1(so)20(ci)12.8(at)18.5(io)18.8(n)]TJ 0 -1.0471 TD [(\(A)15.7(SD)12.4(A)12.4(\))-326.7(cr)19.2(it)16.5(er)13.5(i)13.9(a)-325.5([1)13.9(4].)]TJ 1.0015 -1.0527 TD [(Al)14.9(ph)15.5(a)-410.9(w)0(a)16.9(v)0(e)15.1(s)-411.7(us)14.4(ua)20.8(ll)16.5(y)-410.5(a)0(p)15.1(p)0(e)15.1(a)0(r)-401.9(d)0(u)15.5(r)0(i)17.3(n)0(g)-399.9(w)0(a)11.2(k)0(e)20.8(f)0(u)19.6(l)0(n)13.2(e)0(s)19.6(s)-411.7(wi)14.9(th)]TJ -1.0015 -1.0471 TD [(ey)15.1(es)-293.3(cl)18.4(os)20(ed)-292.2(or)-293.3(in)-288.4(dr)13.9(ow)17.3(sy)-292.9(i)13.9(n)0(d)15.5(i)0(v)18.8(i)0(d)18.9(u)0(a)15.1(l)0(s)17.7(,)-302(w)12.4(i)0(t)16.5(h)-302.4(a)-297.1(f)0(r)12.3(e)0(q)20.8(u)0(e)15.1(n)0(c)20.8(y)-302.4(of)]TJ 0 -1.0527 TD [(7\261)15.5(1)39.1(1)-342.2(cy)20.8(cl)12.8(es)]TJ /F9 1 Tf 4.7004 0.1992 TD (.)Tj /F3 1 Tf 0.2731 -0.1992 TD (s)Tj 7.472 0 0 6.641 362.608 229.323 Tm (-1)Tj 9.963 0 0 9.963 368.561 224.901 Tm [(.)-341.8(D)0(e)16.9(l)0(t)16.5(a)-342.6(wa)16.9(ve)15.1(s)-343.4(a)0(r)19.2(e)-342.6(th)18.9(e)-342.6(s)0(l)17.7(o)0(w)-335.5(w)0(a)16.9(v)0(e)15.1(s)-343.4(of)-333.2(de)15.1(ep)]TJ -5.9466 -1.0471 TD [(sl)17.7(ee)14.7(p,)-308.4(wi)14.9(th)-311.2(a)-325.5(f)0(r)18(e)0(q)20.8(u)0(e)15.1(n)0(c)20.8(y)-325.1(of)]TJ /F7 1 Tf 10.7096 0 TD (<)Tj /F3 1 Tf 0.5463 0 TD 0.3194 Tc [(2c)319.4(y)340.2(c)319.4(l)332.2(e)]TJ /F9 1 Tf 2.8567 0.1992 TD 0 Tc (.)Tj /F3 1 Tf 0.2675 -0.1992 TD (s)Tj 7.472 0 0 6.641 456.378 218.891 Tm -0.0185 Tc (-1)Tj 9.963 0 0 9.963 462.331 214.469 Tm 0 Tc [(,)-319.1(a)0(n)20.8(d)-325.1(an)-309.2(am)17.7(pl)13.2(it)22.2(ud)15.5(e)]TJ /F7 1 Tf -15.3588 -1.0527 TD (>)Tj /F3 1 Tf 0.5463 0 TD (75)Tj /F7 1 Tf 1.3942 0 TD (m)Tj /F3 1 Tf 0.5634 0 TD [(V)131.9(.)-404.4(Al)20.6(ph)15.5(a-)19.2(de)15.1(lt)16.5(a)-405.2(i)0(n)18.9(t)0(r)17.3(u)0(s)20(i)0(o)13.2(n)-399.1(wa)16.9(s)-406(d)0(e)15.1(f)0(i)17.3(n)0(e)20.8(d)-404.8(as)-395.8(th)18.9(e)-405.2(s)0(p)14.3(o)0(n)21.2(-)]TJ -2.5038 -1.0471 TD 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[(fa)13.5(ct)18.4(or)-515.3(as)14(se)19.6(ss)18.9(me)17.7(nt)-521.8(fo)19.6(r)-525.9(t)0(h)18.9(e)-524.7(lu)13.2(ng)-513.7(wi)14.9(th)-516.1(th)18.9(e)-524.7(s)0(i)17.7(n)0(g)15.5(l)0(e)-516.5(b)0(r)19.6(e)0(a)14.7(t)0(h)18.8(-)]TJ 0 -1.0471 TD [(ho)15.5(ld)18.9(in)18.9(g)-484.5(m)0(e)17.7(t)0(h)18.9(o)0(d)-473.8(\()0(t)17.3(r)0(a)13.5(n)0(s)20(f)0(e)13.5(r)-480.4(fa)19.2(ct)12.8(or)-469.8(of)-475.4(th)18.9(e)-484.9(l)0(u)18.9(n)0(g)-473.8(f)0(o)19.6(r)-486.1(ca)20.4(rb)13.9(on)]TJ ET 1 i 58.28 402.463 227.168 -0.51 re f 58.28 376.554 227.168 -0.51 re f 58.28 199.219 227.168 -0.51 re f BT /F2 1 Tf 8.966 0 0 8.966 58.28 425.707 Tm [(Table)-331.9(1.)-336.7(\261)-333.2(Anthropometric,)-479.6(clinical)-482.5(and)-481.1(pulmonary)-483.7(func-)]TJ 0 -1.0559 TD [(tion)-458.2(data)-453(in)-456.6(patients)-457.4(affected)-457.6(by)-452.8(fibromyalgia)-462.2(syndrome)]TJ 0 -1.0496 TD [(\(FMS\))-331.8(and)-335.7(in)-336.5(control)-331.4(subjects)]TJ /F3 1 Tf 12.0262 -1.7135 TD 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[(10)-217.8(s;)-221.3(th)18.9(er)19.2(ef)13.5(or)19.6(e)-228.8(t)0(h)18.9(e)-228.8(R)11.6(D)0(I)]TJ -13.8963 -1.0528 TD [(an)15.1(d)]TJ /F4 1 Tf 1.7299 0 TD (S)Tj /F3 1 Tf 7.97 0 0 7.97 331.483 551.962 Tm [(a,)25.5(O)]TJ 7.472 0 0 6.641 342.425 550.318 Tm (2)Tj 9.963 0 0 9.963 349.228 551.962 Tm [(av)15.1(er)19.2(ag)20.8(e)-314.2(d)0(u)21.2(r)0(i)17.3(n)0(g)-303.1(s)0(l)17.7(e)0(e)14.7(p)-308.1(di)18.9(d)-313.7(n)0(o)21.2(t)-310.4(di)13.2(f)20.4(f)0(e)19.2(r)-315.3(be)20.8(tw)14.9(ee)20.4(n)-313.8(t)0(h)18.9(e)]TJ -4.0061 -1.0471 TD [(tw)14.9(o)-239.8(g)0(r)14(o)0(u)21.2(p)0(s)20(.)-239.4(Ne)11.2(ve)20.8(rt)17.3(he)15.1(le)18.4(ss)18.8(,)-239.4(P)0(B)-233.1(w)0(a)16.9(s)-241(pr)19.6(es)13.9(en)20.8(t)-242.1(f)0(o)19.6(r)-241.4(a)-240.2(m)0(e)17.7(a)0(n)-235.3(1)0(5)21.2(%)]TJ 0 -1.0527 TD [(of)-225.1(th)18.9(e)-228.8(n)0(i)18.9(g)0(h)15.5(t)-230.8(in)-220.2(F)11.4(M)0(S)-224.6(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)13.9(s,)-224.3(ma)17.7(in)18.9(ly)-220.2(oc)15.1(cu)20.8(rr)12.3(in)18.9(g)-228.4(d)0(u)15.5(r)0(i)17.3(n)0(g)-217.8(l)0(i)16.5(g)0(h)21.2(t)]TJ 0 -1.0471 TD [(st)17.7(ag)15.1(es)-401.5(of)-395.8(RE)12.4(M)-406.8(s)0(l)17.7(e)0(e)14.7(p)0(.)-399.5(T)12.2(he)-400.3(pa)15.1(tt)22.2(er)13.5(n)-404.8(o)0(f)-401.5(P)0(B)-403.8(s)0(h)20(o)0(w)17.3(e)0(d)-400.3(a)-410.9(cr)19.2(e-)]TJ 0 -1.0528 TD [(sc)13.9(en)20.8(do)15.5(-d)19.6(ec)14.7(re)19.2(sc)14(en)20.8(do)-468.2(of)-464.1(ti)16.5(da)15.1(l)-475.5(v)0(o)21.2(l)0(u)13.2(m)0(e)17.7(,)-472.7(in)18.8(te)12.8(rr)18(up)21.2(te)12.8(d)-473.1(b)0(y)-468.2(t)0(h)18.9(e)]TJ 0 -1.0471 TD [(br)13.9(ea)20.4(th)13.2(i)13.9(n)0(g)-291.7(p)0(a)15.1(u)0(s)20(e)0(s)13.9(,)-296.3(in)-294.1(1)39.1(1)-296.7(pa)15.1(ti)16.5(en)20.8(ts)-289.6(\(f)12.3(ig)18.9(.)-296.3(1\),)-305.1(while)-314.5(in)-311.2(the)-312.4(four)]TJ 0 -1.0527 TD [(rema)-8.6(ining)-412.6(patients)-413.6(the)-414.8(end)-406.7(of)-407.2(breat)-8.6(hing)-409.5(pause)-415.5(was)-411.9(fol-)]TJ 0 -1.0471 TD [(low)-8.6(ed)-343.4(by)-337.3(an)-343.4(imme)-12.1(diate)-345.1(surge)-337.1(of)-338.9(venti)-9(lation,)-348.2(with)-347.5(a)-336.9(pat-)]TJ 0 -1.0528 TD [(tern)-513.9(more)-514.7(similar)-513.9(to)-510.4(a)-507.6(cluster)-514.5(\(fig.)-509.8(2\).)-510(A)-511.2(compa)-7.8(rison)]TJ 0 -1.0471 TD [(betw)-9.8(een)-407.1(patien)-10.2(ts)-403.4(with)-410.1(or)-407.2(wi)-7.8(thout)-406.9(PB)-409.5(was)-411.8(not)-408.7(possible,)]TJ 0 -1.0528 TD [(since)-383.8(only)-375.3(two)-372.8(p)-6.5(atients)-378.7(had)-378.3(no)-371.4(PB)-375.3(at)-374.2(all.)-377.7(The)-376.7(best)-376.9(cor-)]TJ 0 -1.0471 TD [(relat)-11(ions)-348.1(between)-354.3(PB)-346.9(and)-349.8(funct)-8.2(ional)-350.4(data)-347.7(wer)-8.2(e)-342.6(o)-6.5(btained)]TJ 0 -1.0527 TD [(wi)-7.8(th)]TJ /F4 1 Tf 2.0998 0 TD (T)Tj /F3 1 Tf 7.97 0 0 7.97 335.735 426.444 Tm (L,CO)Tj 9.963 0 0 9.963 353.537 426.444 Tm [(,)-336.1(DEF)-333.9(and)]TJ /F4 1 Tf 4.5695 0 TD (P)Tj /F3 1 Tf 7.97 0 0 7.97 405.071 426.444 Tm (a,CO)Tj 7.472 0 0 6.641 421.568 424.8 Tm (2)Tj 9.963 0 0 9.963 428.598 426.444 Tm [(\(tabl)-10.6(e)-331.2(4\).)]TJ -10.9714 -1.0471 TD [(Pa)15.9(ti)16.5(en)15.1(ts)-187.2(co)15.1(mp)18.1(la)18.4(in)18.9(in)13.2(g)-194.2(o)0(f)-190.9(d)0(a)15.1(y)0(t)18.9(i)0(m)15.7(e)-200.3(hy)21.2(pe)15.1(rs)18.4(om)18.1(no)15.5(le)18.4(nc)15.1(e)-200.3(h)0(a)20.8(d)-199.9(a)]TJ -1.0015 -1.0527 TD [(hi)13.2(gh)21.2(er)-242.5(nu)21.2(mb)12.4(er)-236.8(of)-242.1(T)12.2(P)113.8(,)-250.8(a)0(b)20.8(o)0(u)15.5(t)-247.8(do)15.5(ub)21.2(le)-237.6(th)13.2(e)-245.9(n)0(u)15.5(m)0(b)18.1(e)0(r)-236.8(o)0(f)-242.1(a)0(r)19.2(o)0(u)15.5(s)0(a)19.6(l)0(s)]TJ 0 -1.0471 TD [(pe)15.1(r)-224.3(h)0(o)21.2(u)0(r)-213.7(a)0(n)20.8(d)-222.7(a)-223.1(l)0(o)18.8(w)0(e)16.9(r)-224.3(sl)17.7(ee)20.4(p)-222.7(e)0(f)24.9(f)0(i)17.3(c)0(i)18.5(e)0(n)20.8(c)0(y)-212.5(t)0(h)13.2(a)0(n)-212.5(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)13.9(s)-223.9(w)0(h)17.3(o)-222.7(di)18.8(d)]TJ 0 -1.0528 TD [(no)15.5(t)-230.8(r)0(e)19.2(p)0(o)15.5(r)0(t)-221.7(t)0(h)18.9(i)0(s)-221.3(s)0(y)20(m)0(p)18.1(t)0(o)13.2(m)0(.)]TJ /F4 1 Tf 9.765 0 TD (T)Tj /F3 1 Tf 7.97 0 0 7.97 411.987 384.605 Tm 0.0001 Tc [(L,)21.9(CO)]TJ 9.963 0 0 9.963 431.887 384.605 Tm 0 Tc [(w)12.4(a)0(s)-225.1(m)0(o)18.1(r)0(e)-219.8(i)0(m)15.7(p)0(a)15.1(i)13.9(re)13.5(d)-228.4(a)0(n)15.1(d)-228.4(th)18.9(e)]TJ -12.303 -1.0471 TD [(oc)15.1(cu)15.1(rr)18(en)20.8(ce)-235.7(of)-236.4(P)11.4(B)-244.5(hi)18.9(gh)15.5(er)-236.8(\(t)17.3(ab)20.8(le)-237.6(5\))-242.1(in)-254.3(pati)-8.2(ents)-257.4(with)-256.4(daytime)]TJ 0 -1.0528 TD [(hyp)-8(ersomnole)-10.3(nce.)]TJ /F6 1 Tf 9.1675 -1.9576 TD [(Discu)-10.9(ssion)]TJ /F4 1 Tf -9.1675 -1.6503 TD [(Sleep)-342.8(ar)31.4(chit)-8.2(ectur)25.9(e)-331.2(and)-338(hypers)-7.8(omnolence)]TJ /F3 1 Tf 1.0015 -1.6503 TD [(FM)14.4(S)-239(i)0(s)-232.7(a)-245.9(di)18.9(se)19.6(as)13.9(e)-240.2(w)0(i)14.9(t)0(h)-231.5(a)-240.2(hi)18.9(gh)15.5(er)-231.1(fe)19.2(ma)12(le)-231.9(pr)19.6(ev)15.1(al)18.4(en)15.1(ce)20.4(,)-239.4(c)0(a)14.7(u)0(s)20(-)]TJ -1.0015 -1.0527 TD [(in)13.2(g)-382(p)0(o)21.2(o)0(r)-373(s)0(l)17.7(e)0(e)14.7(p)-382(in)-373.8(60)15.5(\2619)21.2(0%)-373.8(of)-378.7(su)20(bj)18.9(ec)14.7(ts)-375([1)19.6(,)-381.7(3)0(\261)15.5(5)0(])19.6(.)-381.6(It)-375.4(is)-375(no)21.2(t)]TJ 0 -1.0471 TD [(su)14.4(rp)19.6(ri)17.3(si)17.7(ng)-280.4(th)18.9(at)-283.1(th)18.8(e)-291.4(c)0(u)20.8(r)0(r)12.4(e)0(n)20.8(t)-287.7(ca)14.7(se)-282(se)19.6(ri)17.3(es)-282(of)-282(co)20.8(ns)14.4(ec)20.4(ut)18.9(iv)13.2(e)-285.7(F)0(M)14.4(S)]TJ 0 -1.0528 TD [(pa)15.1(ti)16.5(en)20.8(ts)-340.8(se)19.6(le)18.4(ct)18.5(ed)-337.7(a)-348.3(p)0(r)19.6(e)0(d)15.1(o)0(m)18.1(i)0(n)18.9(a)0(n)15.1(t)0(l)22.2(y)-347.9(fe)19.2(ma)12(l)13.9(e)-348.3(po)15.5(pu)21.2(la)18.4(ti)16.5(on)-337.3(wh)17.3(o)]TJ 0 -1.0471 TD [(co)15.1(mp)18.1(la)18.4(in)13.2(ed)-434.4(of)-441.3(sy)20(mp)18.1(to)18.8(ms)-438.3(su)14.4(ch)-434.4(as)-441.3(no)21.2(ct)12.8(ur)19.6(na)20.8(l)-447(a)0(w)16.9(a)0(k)15.1(e)0(n)15.1(i)13.9(ng)15.5(,)]TJ 0 -1.0527 TD [(po)15.5(or)-230.7(sl)17.7(ee)20.4(p)-239.8(q)0(u)21.2(a)0(l)12.8(i)0(t)16.5(y)73.2(,)-233.7(f)0(a)13.5(t)0(i)16.5(g)0(u)21.2(e)0(,)-229.2(m)0(o)18.1(r)0(n)13.9(i)0(n)18.9(g)-239.8(he)20.8(ad)15.1(ac)20.4(he)-229.6(an)15.1(d)-234.1(w)0(a)16.9(k)0(i)13.2(n)0(g)21.2(-)]TJ 0 -1.0471 TD [(up)-394.2(un)21.2(re)13.5(fr)18(es)19.6(he)15.1(d)-399.1(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)18.5(a)0(n)15.1(t)0(l)16.5(y)-399.1(mo)18.1(re)-390.5(of)19.6(te)12.8(n)-399.1(t)0(h)18.8(a)0(n)-388.9(t)0(h)18.8(e)-399.5(co)15.1(nt)18.9(ro)19.6(l)]TJ 0 -1.0528 TD [(gr)13.9(ou)21.2(p.)-427.9(Ho)11.6(w)12.4(e)0(v)15.1(e)0(r)47.7(,)-438.6(th)18.9(e)-439.3(s)0(e)19.6(v)0(e)15.1(r)0(i)17.3(t)0(y)-425(o)0(f)-429.9(t)0(h)13.2(e)0(s)19.6(e)-439.3(sy)20(mp)18.1(to)13.2(ms)-427(is)-431.9(no)21.2(t)]TJ T* [(su)14.4(pp)21.2(or)13.9(te)18.4(d)-342.2(b)0(y)-325.9(a)0(n)15.1(y)-342.2(fi)17.3(nd)21.2(in)18.9(g)-342.2(o)0(f)-333.2(d)0(r)19.6(a)0(m)17.7(a)0(t)12.8(i)0(c)-328.7(a)0(l)18.5(t)0(e)12.8(r)0(a)19.2(t)0(i)16.5(o)0(n)21.2(s)-343.4(in)-328.3(PS)17.1(G.)]TJ 0 -1.0471 TD [(Th)17.1(e)-211.7(a)0(m)12(o)0(u)21.2(n)0(t)-203.1(o)0(f)-202.3(s)0(t)17.7(a)0(g)15.1(e)-211.7(1)-211.3(s)0(l)17.7(e)0(e)14.7(p)-211.3(wa)16.9(s)-212.5(i)0(n)18.8(c)0(r)19.2(e)0(a)14.7(s)0(e)19.6(d)-211.3(in)-203.1(FM)14.4(S)-210.5(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)]TJ 0 -1.0527 TD [(to)-197.4(a)-211.7(m)0(e)17.7(a)0(n)-195.4(2)0(1)15.5(%)-208(of)-196.6(sl)17.7(ee)14.7(p)-205.6(t)0(i)16.5(m)0(e)17.7(,)-205.2(bu)15.5(t)-202.3(o)0(n)15.5(l)0(y)-197.4(s)0(l)17.7(o)0(w)-198.9(w)0(a)16.9(v)0(e)-195.4(s)0(l)17.7(e)0(e)14.7(p)-205.6(wa)16.9(s)]TJ 0 -1.0471 TD [(re)13.5(du)21.2(ce)14.7(d.)-217.4(Al)14.9(th)18.9(ou)21.2(gh)-217.8(M)]TJ 6.974 0 0 6.974 392.542 196.214 Tm 0.0001 Tc [(OL)21.5(DOF)29.1(SKI)]TJ /F4 1 Tf 9.963 0 0 9.963 428.598 196.214 Tm 0 Tc [(et)-214.9(al)]TJ /F3 1 Tf 1.912 0 TD [([6)19.6(])-241.4(showed)-243.4(that)-235.8(a)-240.2(slow)]TJ -13.8849 -1.0527 TD [(wave)-497.2(sleep)-491.9(depriva)-10.1(tion)-491.5(could)-490.3(exacerba)-9.7(te)-488(pain)-495.2(and)-486.4(as-)]TJ 0 -1.0471 TD [(theni)-9(a)-285.7(durin)-7.8(g)-285.3(the)-289.6(daytime,)-293.3(this)-287.8(can)-293.3(hardly)-287.8(exp)-8.4(lain)-287.1(hyper-)]TJ 0 -1.0528 TD [(somn)-7.4(olence)-8.2(.)-210.9(The)-211.7(amoun)-7.4(t)-208(o)0(f)-213.7(both)-216(stage)-213.1(2)-211.3(and)-213.2(REM)-212.3(phases)]TJ 0 -1.0471 TD [(was)-411.8(not)-408.7(different)-409.9(from)-413.4(contr)-8.2(ol)-407.9(subjects,)-412.8(thus)-410.6(exc)-8.8(luding)]TJ 0 -1.0528 TD [(REM)-240.7(deprivati)-10.7(on)-234.8(as)-230.8(a)-234.5(possible)-241.3(cause)-239.5(of)-230.8(excess)-8.2(ive)-238.4(anxiety)]TJ 0 -1.0471 TD [(or)-344.6(p)-6.5(sychologica)-9.9(l)-344.6(disorders)-351(whi)-8.6(ch)-343.4(could)-348(lead)-347.7(to)-345.3(an)-343.4(over-)]TJ 0 -1.0528 TD [(esti)-9.4(mation)-479.5(of)-475.4(symp)-7.4(toms.)-476.8(The)-479.1(numbe)-7.4(r)-474.7(o)0(f)-475.4(arousa)-8.2(ls)-477.4(was)]TJ 0 -1.0471 TD [(abo)-8.4(ut)-220.2(tw)-7.8(ice)-227.4(that)-224.5(in)-225.8(contr)-8.2(ol)-225.8(subjects,)-230.7(but)-226.6(still)-230.8(lower)-228.4(than)-227.8(10)]TJ ET 1 i 59.131 354.557 227.168 -0.51 re f 59.131 328.649 227.168 -0.51 re f 59.131 141.846 227.168 -0.51 re f BT /F2 1 Tf 8.966 0 0 8.966 59.131 368.39 Tm [(Table)-338.3(3.)-330.4(\261)-333.2(Polysomnographic)-585.5(data)-579.5(in)-576.8(fibromyalgia)-582.3(syn-)]TJ 0 -1.0559 TD [(drome)-333(\(FMS\))-338.1(patients)-330.9(and)-335.7(control)]TJ /F3 1 Tf 11.5962 -1.7072 TD [(FMS)-3195.7(Control)]TJ 5.1089 -1.0559 TD (subjects)Tj 5.2923 1.0559 TD (p-value)Tj -21.9974 -3.054 TD [(Sleep)-339.4(time)-333.2(min)-4959.9(303\21380)-2662.1(398\21333)-2409.2(0.001)]TJ 0 -1.0559 TD [(Stage)-339.4(1)-328.3(%)-335.1(sleep)-335.7(time)-2982.5(21\2136)-3693.8(1)32.1(1\2134)-2910.3(0.001)]TJ T* [(Stage)-339.4(2)-328.3(%)-335.1(sleep)-335.7(time)-2982.5(34\2138)-3662.2(38\2138)]TJ 6.276 0 0 6.276 265.663 297.298 Tm 0.0001 Tc (NS)Tj 8.966 0 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" Iid4ZbI@\GeDV xo܂2rC*NA}2ńSC.ђm{\ qGd#eq;+4,u $'h$CːغbN4r8 n0\LR >` #!2D2"/qㆾjjh84rܘ'<P9;6> stream BT /F3 1 Tf 9.963 0 0 9.963 58.28 540 Tm 0 g /GS2 gs 0 Tc [(episo)-7.8(des)]TJ /F9 1 Tf 3.4257 0.2049 TD 0 Tw (.)Tj /F3 1 Tf 0.2675 -0.2049 TD (h)Tj 7.472 0 0 6.641 100.063 544.479 Tm (-1)Tj 9.963 0 0 9.963 106.242 540 Tm [(,)-296.3(a)-302.8(figur)-9.4(e)-297.1(which)-306.4(is)-301(rarel)-10.2(y)-296.7(associ)-10.1(ated)-302.2(with)-307.7(hy-)]TJ -4.8142 -1.0698 TD [(persom)-10.9(nolence)-344.7(and)-344.1(far)-341.6(lower)-342.2(than)-347.3(that)-344(reported)-348.2(in)-339.7(other)]TJ 0 -1.0755 TD [(disea)-8.2(ses)-534.3(cau)-8.8(sing)-535.8(poor)-539.6(sleep)-543.1(quality)-542.1(and)-537.6(hypers)-7.8(omno-)]TJ T* [(lence,)-337.8(\()]TJ /F4 1 Tf 2.9932 0 TD (i.e.)Tj /F3 1 Tf 1.5364 0 TD [(obstr)-9(uctive)-334.5(sleep)-338.2(apnoea)-335.8(syndro)-7.4(me)-335.1(\(OSAS\)\))-10.7(.)]TJ -4.5297 -1.0755 TD [(The)-575.9(a)-6.9(nalysis)-581.9(of)-577.9(arousal)-580.4(was)-582.6(performed)-584.7(accordi)-10.5(ng)-576.3(to)]TJ T* [(ASDA)-213.2(crit)-9.8(eria)-212.7([14],)-211.5(whi)-8.6(ch)-206.8(incl)-8.2(ude)-207.6(both)-216(EEG)-213.6(arousals)-218.1(and)]TJ T* [(movem)-10.5(ent)-414.8(arousa)-8.2(ls)-414.8(lasting)]TJ /F7 1 Tf 11.3242 0 TD (>)Tj /F3 1 Tf 0.552 0 TD [(3)-416.2(s)0(.)-412.1(The)-422.2(alpha-delt)-11.9(a)-410.9(intr)-9.4(u-)]TJ -11.8762 -1.0755 TD [(sion,)-445.2(report)-10.5(ed)-445.8(in)-442.1(a)-445(previ)-8.2(ous)-441.7(study)-451.3(as)-441.3(a)-445(possi)-8.6(ble)-443.2(facto)-8.6(r)]TJ T* [(disrup)-9.7(ting)-320.8(sleep)-332.6([9],)-324.5(occurr)-8.6(ed)-320.6(sporad)-7.8(ically)-331.2(in)-322.6(the)-323.7(curren)-8.6(t)]TJ T* [(series)-353.2(of)-350.2(patients;)-354.1(there)-8.6(fore,)-348.5(a)-348.3(paramount)-356.2(role)-348.9(in)-345.3(the)-352.2(pa-)]TJ T* [(thogen)-7.4(esis)-304.1(of)-304.7(hypers)-7.8(omnolence)-309.5(cannot)-309.4(be)-303.5(alleged)-307.2(on)-303.1(the)]TJ T* [(basis)-287.8(of)-282(these)-287(data.)-291.2(The)-280(presen)-8.2(ce)-286.9(of)-282(anothe)-7.8(r)-281.2(sleep)-287(relat)-11(ed)]TJ 0 -1.0698 TD [(respirato)-11.1(ry)-350.3(disor)-9(der)29.9(,)-353.2(namely)-358(OSAS,)-356.8(was)-354.9(not)-351.8(detected)-359.6(in)]TJ 0 -1.0755 TD [(this)-242.3(popula)-7.4(tion)-246.8(of)-242.1(nonobes)-6.9(e)-240.2(FMS)-241.7(pati)-8.2(ents,)-240.7(alth)-8.2(ough)-242.1(more)]TJ T* [(than)-324.5(half)-320.4(wer)-8.2(e)-314.2(snorer)-9.4(s,)-321(a)-319.8(result)-325.5(in)-316.9(accordan)-9.3(ce)-321(with)-324.7(M)]TJ 6.974 0 0 6.974 273.94 390.104 Tm 0.0001 Tc (OL-)Tj -30.9243 -1.5365 TD (ONY)Tj /F4 1 Tf 9.963 0 0 9.963 76.309 379.389 Tm 0 Tc [(et)-379.9(al)]TJ /F3 1 Tf 2.2421 0 TD [([10].)-382.2(Also,)-386.5(the)-380.7(possi)-8.6(bility)-384(of)-384.4(an)-383.2(upper)-381.4(airw)-11.4(ay)]TJ -4.0517 -1.0755 TD [(resistanc)-11.1(e)-217.4(syndro)-7.4(me)-221.3(seem)-8.2(s)-218.2(t)0(o)-220.2(b)0(e)-218.2(exclud)-7.8(ed)-218.2(by)-223.5(a)-217.4(numbe)-7.4(r)-218.6(o)0(f)]TJ T* [(arousa)-8.2(ls)-335.2(lower)-342.2(than)-335.9(10)-331.6(h)]TJ 7.472 0 0 6.641 158.4 362.381 Tm (-1)Tj 9.963 0 0 9.963 164.523 357.959 Tm (.)Tj 15.5352 18.2724 TD [(It)-267.3(is)-266.9(th)18.8(us)-264.5(po)15.5(ss)18.8(ib)18.9(le)-266.1(th)18.9(at)-266.1(th)18.8(e)-274.3(u)0(s)20(u)0(a)15.1(l)-270.6(cr)13.5(it)16.5(er)19.2(ia)-266.1(ap)20.8(pl)13.2(i)13.9(e)0(d)-269.4(t)0(o)-260(o)0(t)13.2(h)0(e)20.8(r)]TJ -1.0015 -1.0471 TD [(pa)15.1(ti)16.5(en)20.8(ts)-346.5(\()]TJ /F4 1 Tf 3.6761 0 TD [(i.)19.2(e.)]TJ /F3 1 Tf 1.5308 0 TD [(OS)18.1(AS)-346.1(pa)20.8(ti)16.5(en)15.1(ts)17.7(\))-349.5(c)0(a)14.7(n)0(n)21.2(o)0(t)-345.3(b)0(e)-343.4(u)0(s)20(e)0(d)-343.4(i)0(n)-339.6(F)0(M)14.4(S)-352.8(pa)20.8(-)]TJ -5.2069 -1.0527 TD [(ti)16.5(en)15.1(ts)17.7(.)-267.8(T)12.2(he)-258(sh)20(or)13.9(te)18.4(r)-269.8(i)13.9(nt)13.2(er)19.2(va)15.1(l)-264.9(f)0(r)18(o)0(m)-260.8(t)0(h)18.8(e)-268.6(on)21.2(se)14(t)-264.9(o)0(f)-259.2(d)0(i)18.9(s)0(e)19.6(a)0(s)13.9(e)-262.9(co)15.1(ul)18.8(d)]TJ 0 -1.0471 TD [(po)15.5(ss)18.9(ib)18.9(ly)-225.8(pl)18.9(ay)-223.9(a)-228.8(m)0(a)12(j)0(o)18.8(r)-230(ro)13.9(le)18.4(,)-228(s)0(i)17.7(n)0(c)15.1(e)-234.5(i)13.9(t)-236.5(w)12.4(a)0(s)]TJ /F7 1 Tf 15.2791 0 TD (<)Tj /F3 1 Tf 0.5463 0 TD [(5)-228.4(y)0(r)19.6(s)-235.3(as)-225.1(a)-228.8(m)0(e)17.7(a)0(n)-223.9(i)0(n)]TJ -15.8254 -1.0528 TD [(th)13.2(e)-422.3(F)0(M)14.4(S)-421.1(pa)15.1(ti)16.5(en)20.8(ts)17.7(,)-427.2(w)0(h)17.3(i)0(l)16.5(s)0(t)-414.8(O)0(S)18.1(A)0(S)-420.1(p)0(a)15.1(t)13.9(ie)12.8(nt)18.8(s)-423.1(u)0(s)14.4(u)0(a)20.8(l)0(l)16.5(y)-427.6(ha)20.8(ve)-417.3(a)]TJ 0 -1.0471 TD [(lo)13.2(ng)-200.7(hi)18.9(st)17.7(or)13.9(y)-211.3(o)0(f)-208(s)0(n)20(o)0(r)19.6(i)0(n)13.2(g)-211.3(pr)19.6(og)15.5(re)19.2(ss)13.2(i)13.9(n)0(g)-206.4(o)0(n)15.5(l)0(y)-203.1(s)0(l)17.7(o)0(w)17.3(l)0(y)-203.1(\()0(o)14(f)0(t)17.3(e)0(n)-201.1(o)0(v)15.5(e)0(r)]TJ 0 -1.0528 TD [(de)15.1(ca)14.7(de)20.8(s\))-203.5(to)-208.8(OS)18.1(AS)-203.8([1)13.9(6].)-214.1(The)-228.7(high)-227.4(female)-229.1(preval)-9.4(ence)-226.2(could)]TJ 0 -1.0471 TD [(play)-472.5(a)-462.1(role)-468.4(as)-464.1(well,)-467.8(since)-469.1(fema)-8.6(les)-467.2(tend)-466.8(to)-464.8(over)-471.7(report)]TJ 0 -1.0527 TD [(symp)-7.4(toms)-339.8(of)-333.2(sleep)-338.2(dist)-9(urbance)-338.2([17].)]TJ /F4 1 Tf 0 -2.0486 TD [(Per)-8(iodic)-339(br)31.4(eathi)-9(ng)-331.6(and)-338(diffusion)-341.9(abnorm)-9.7(alities)]TJ /F3 1 Tf 1.0015 -1.5478 TD [(An)-233.1(in)18.9(tr)17.3(ig)18.8(ui)18.9(ng)-229.2(fi)17.3(nd)15.5(in)18.8(g)-234.1(o)0(f)-230.7(t)0(h)18.8(i)0(s)-227(s)0(t)17.7(u)0(d)15.5(y)-234.1(wa)16.9(s)-235.3(t)0(h)18.9(e)-240.2(os)20(ci)18.5(ll)16.5(at)12.8(i)13.9(o)0(n)-229.2(i)0(n)]TJ -1.0015 -1.0471 TD [(ve)15.1(nt)18.9(il)16.5(at)18.5(io)18.9(n)-342.2(d)0(u)15.5(r)0(i)17.3(n)0(g)-331.6(s)0(l)17.7(e)0(e)20.4(p)-342.2(ob)15.5(se)19.6(rv)19.6(ed)-332(in)-334(15)15.5(/1)18.9(7)-342.2(F)11.4(MS)-332.7(pa)15.1(t)13.9(i)0(e)12.8(n)0(t)18.9(s)0(,)]TJ 0 -1.0528 TD [(st)17.7(ru)13.9(ct)18.5(ur)19.6(ed)-258(in)-260(a)-262.9(t)0(y)13.2(p)0(i)18.9(c)0(a)20.4(l)-270.6(pe)20.8(ri)17.3(od)15.5(ic)-254.7(br)13.9(ea)20.4(th)18.9(in)13.2(g)-262.5(p)0(a)15.1(t)0(t)16.5(e)0(r)19.2(n)-262.5(oc)15.1(cu)15.1(rr)18(in)18.8(g)]TJ 0 -1.0471 TD [(ma)12(in)18.8(ly)-208.8(du)21.2(ri)17.3(ng)-206.4(Ph)16.3(as)19.6(e)-217.4(1)0(.)-206(T)0(h)17.1(i)0(s)-210(d)0(i)18.9(d)-217(no)21.2(t)-219.4(a)0(f)30.6(f)0(e)13.5(c)0(t)-203.5(t)0(h)13.2(e)-211.7(RD)12.6(I)-218.6(b)0(e)20.8(c)0(a)14.7(u)0(s)20(e)]TJ 0 -1.0528 TD [(mo)12.4(st)-352.2(ap)15.1(no)21.2(ei)18.4(c)-365.4(a)0(n)15.1(d)-365(hy)21.2(po)15.5(pn)21.2(oe)15.1(ic)-357.1(ep)20.8(is)17.7(od)15.5(es)-355.9(l)13.9(a)0(s)13.9(t)0(e)18.4(d)]TJ /F7 1 Tf 18.7048 0 TD (<)Tj /F3 1 Tf 0.5406 0 TD [(10)-354.3(s.)-355.2(On)]TJ -19.2454 -1.0471 TD [(th)13.2(e)-228.8(c)0(o)20.8(n)0(t)13.2(r)0(a)19.2(r)0(y)82.2(,)-228(th)13.2(e)-228.8(D)0(E)18.9(F)-233.3(w)12.4(a)0(s)-225.1(i)0(n)18.8(c)0(r)19.2(e)0(a)14.7(s)0(e)19.6(d)0(,)-223.1(d)0(e)20.8(s)0(p)20(i)0(t)16.5(e)-228.8(th)13.2(e)-228.8(h)0(i)18.8(g)0(h)-217.8(b)0(a)15.1(s)0(a)19.6(l)]TJ /F4 1 Tf 0 -1.0527 TD (S)Tj /F3 1 Tf 7.97 0 0 7.97 314.249 357.732 Tm [(a,)25.5(O)]TJ 7.472 0 0 6.641 325.19 356.088 Tm (2)Tj 9.963 0 0 9.963 331.37 357.732 Tm [(va)15.1(lu)18.8(es)19.6(,)-250.8(a)0(n)20.8(d)-251.2(th)18.9(e)-251.6(s)0(h)20(o)0(r)19.6(t)-253.5(l)13.9(e)0(n)15.1(g)0(t)18.9(h)-251.1(of)-236.4(ap)15.1(no)15.5(ea)20.4(s/)17.7(hy)15.5(po)21.2(pn)15.5(oe)20.8(as)13.9(.)]TJ ET 0 0 0 0 k /GS3 gs q 0 162.9928 -462.7463 0 535.539 621.3762 cm /Im1 Do Q 0 0 0 1 k q 0 162.9928 -462.7463 0 535.539 621.3762 cm /Im2 Do Q 0 0 0 0 k 0 0 0 0 K 0 J 0 j 0.5 w 3.864 M []0 d 1 i 58.78 636.866 490.497 -26.5 re B 65.28 779.865 40.5 -173.249 re B 533.278 789.365 12 -181.499 re B 90.28 795.365 454.498 -19 re B BT /F15 1 Tf 10 0 0 10 77.708 766.938 Tm 0 0 0 1 k /GS4 gs (LEOG)Tj ET 0 0 0 1 K /GS3 gs 105.994 626.389 m 105.994 781.365 l S BT 10 0 0 10 76.357 749.008 Tm /GS4 gs (REOG)Tj 0.3643 -1.797 TD (C4A2)Tj 0 -1.6872 TD (C3A1)Tj 0.3651 -2.194 TD (Chin)Tj 0.5015 -1.6796 TD (RR)Tj -0.4561 -1.1432 TD (NAF)Tj -0.091 -1.2508 TD (THO)Tj 0.0451 -1.2236 TD (ABD)Tj /F17 1 Tf -0.283 -1.1424 TD (S)Tj /F15 1 Tf 8 0 0 8 86.286 627.831 Tm (a,O)Tj 1.322 -0.3543 TD (2)Tj 10 0 0 10 134.284 615.851 Tm (10)Tj 17.2634 -1.3296 TD [(T)18(ime s)]TJ ET /GS3 gs 106.28 625.866 m 536.278 625.866 l S BT 10 0 0 10 167.907 615.764 Tm /GS4 gs [(20)-2713(30)]TJ 28.3479 0.0074 TD [(100)-2411.2(1)60(1)0(0)-1862(120)]TJ 6 0 0 6 117.295 631.316 Tm (92)Tj 2.5308 -0.1837 TD (92)Tj 2.3333 0.0833 TD (91)Tj 2.5 -0.1667 TD (89)Tj 2.4583 -0.0417 TD [(88)-1504.7(88)]TJ 4.9167 0.1667 TD (88)Tj 2.2903 -0.125 TD [(88)-1506(88)]TJ 4.8763 0.0833 TD (89)Tj 2.3333 0.0417 TD (89)Tj 2.4167 0.0833 TD [(89)-1546.3(89)]TJ 4.75 0.0833 TD (90)Tj 2.3333 -0.0417 TD (91)Tj 2.4167 0.1667 TD (92)Tj 2.375 -0.125 TD (91)Tj 2.4167 0.0417 TD (91)Tj 2.25 -0.25 TD (89)Tj 2.5833 0.0417 TD (89)Tj 2.25 0.0833 TD (90)Tj 2.5833 0.0417 TD (91)Tj 2.4167 -0.2083 TD (91)Tj 2.25 0.25 TD (91)Tj 2.6667 -0.2917 TD (89)Tj 2.1667 -0.3334 TD (86)Tj 2.5833 -0.0417 TD (85)Tj 2.375 -0.0833 TD (84)Tj 2.375 0.0833 TD (86)Tj 10 0 0 10 238.097 615.991 Tm [(40)-2663(50)-2913(60)-2663(70)-2438(80)-2713(90)]TJ ET 0 0 0 0 k 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[(th)18.9(er)13.5(e)-365.4(a)0(r)19.2(e)-365.4(no)-360(pr)19.6(ev)15.1(io)18.9(us)-355.5(re)13.5(po)21.2(rt)17.3(s)-366.2(o)0(f)-361.6(t)0(h)18.9(i)0(s)-357.9(f)0(i)17.3(n)0(d)15.5(i)0(n)18.9(g)-365(in)-356.7(FM)14.4(S)-364.2(p)0(a)15.1(-)]TJ T* [(ti)16.5(en)20.8(ts)17.7(,)-330.4(p)0(r)13.9(o)0(b)21.2(a)0(b)15.1(l)0(y)-316.9(b)0(e)15.1(c)0(a)14.7(u)0(s)20(e)-331.2(th)18.9(is)-318.1(in)13.2(de)20.8(x)-330.8(i)0(s)-318.1(n)0(o)15.5(t)-327.5(ro)13.9(ut)18.9(in)18.8(el)18.5(y)-330.8(m)0(e)17.7(a)0(s)13.9(-)]TJ T* [(ur)19.6(ed)15.1(,)-199.6(s)0(i)17.7(n)0(c)15.1(e)-200.3(pu)15.5(lm)15.7(on)21.2(ar)13.5(y)-199.9(f)0(u)19.6(n)0(c)15.1(t)0(i)16.5(o)0(n)-189.3(a)0(n)15.1(d)-199.9(bl)18.9(oo)15.5(d)-199.9(g)0(a)15.1(s)0(e)19.6(s)-201.1(ar)13.5(e)-200.3(u)0(s)20(u)0(a)15.1(l)0(l)16.5(y)]TJ T* [(no)15.5(rm)16.5(al)18.5(,)-330.4(a)0(s)-321.8(w)12.4(as)-321.8(th)13.2(e)-325.5(c)0(a)14.7(s)0(e)-321.8(i)0(n)-322.6(t)0(h)18.9(e)0(s)19.6(e)-331.2(pa)15.1(t)13.9(i)0(e)12.8(n)0(t)18.9(s)0(.)-321(W)0(h)20.1(e)0(n)]TJ /F4 1 Tf 19.5186 0 TD (T)Tj /F3 1 Tf 7.97 0 0 7.97 258.123 302.4 Tm 0.0001 Tc [(L,)21.9(CO)]TJ 9.963 0 0 9.963 278.986 302.4 Tm 0 Tc (is)Tj 3.0444 47.1007 TD [(re)13.5(du)21.2(ce)14.7(d,)-262.9(a)-274.3(n)0(o)15.5(r)0(m)16.5(a)0(l)-260.4(o)0(x)15.5(y)0(g)15.5(e)0(n)-263.7(t)0(e)18.4(n)0(s)20(i)0(o)13.2(n)-268.2(in)-265.7(ar)13.5(te)18.4(ri)17.3(al)-266.1(bl)18.9(oo)21.2(d)-273.9(\()]TJ /F4 1 Tf 20.4177 0 TD (P)Tj /F3 1 Tf 7.97 0 0 7.97 518.683 771.647 Tm [(a,)18.4(O)]TJ 7.472 0 0 6.641 529.625 770.003 Tm (2)Tj 9.963 0 0 9.963 533.253 771.647 Tm (\))Tj -22.4777 -1.0755 TD [(is)-477.4(ma)17.7(in)13.2(t)13.9(a)0(i)12.8(n)0(e)20.8(d)-484.5(on)15.5(ly)-476.2(by)-473.8(hy)21.2(pe)15.1(rv)19.6(en)15.1(ti)16.5(la)18.4(ti)16.5(on)-473.8(wh)17.3(ic)18.5(h)-484.5(c)0(a)14.7(u)0(s)20(e)0(s)-475.4(a)]TJ /F4 1 Tf T* (P)Tj /F3 1 Tf 7.97 0 0 7.97 315.269 750.217 Tm 0.0001 Tc [(a,)18.5(CO)]TJ 7.472 0 0 6.641 331.427 748.573 Tm 0 Tc (2)Tj 9.963 0 0 9.963 339.704 750.217 Tm [(de)20.8(cr)13.5(ea)20.4(se)13.9(.)-449.9(C)0(o)16.5(m)0(p)18.1(a)0(r)13.5(i)0(n)18.9(g)-456(F)11.4(M)0(S)-446.6(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-449(s)0(h)20(o)0(w)17.3(i)0(n)18.9(g)-456(PB)]TJ -3.0501 -1.0755 TD [(wi)14.9(th)-225.8(co)20.8(nt)13.2(ro)19.6(l)-230.8(s)0(u)14.4(b)0(j)18.9(e)0(c)20.4(t)0(s)17.7(,)-233.7(th)18.9(e)]TJ /F4 1 Tf 9.9641 0 TD (P)Tj /F3 1 Tf 7.97 0 0 7.97 414.538 739.502 Tm 0.0001 Tc [(a,)25.6(CO)]TJ 7.472 0 0 6.641 430.696 737.858 Tm 0 Tc (2)Tj 9.963 0 0 9.963 436.705 739.502 Tm -0.0184 Tc [(w)-18.4(a)-1.5(s)-253.7(s)-18.4(li)-18.4(gh)-18.4(tl)-18.4(y)-244.2(l)-18.4(ow)-18.4(er)-254.1(b)-18.4(u)2.8(t)-254.9(t)-18.4(he)]TJ -12.7867 -1.0755 TD 0 Tc [(di)13.2(f)20.4(f)0(e)19.2(r)0(e)13.5(n)0(c)20.8(e)-325.5(di)18.9(d)-330.8(n)0(o)21.2(t)-327.5(re)19.2(ac)14.7(h)-325.1(a)-325.5(st)17.7(at)18.5(is)17.7(ti)16.5(ca)20.4(l)-327.5(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(c)0(e)-315.3(\()0(4)19.6(.)0(8)15.9(\213)11.8(0.)15.9(3)]TJ /F4 1 Tf 0 -1.0698 TD [(ve)14.7(rs)18.8(us)]TJ /F3 1 Tf 2.8111 0 TD [(5.)15.9(3\213)16.7(0.)21.6(7)-325.1(k)0(P)16.3(a)0(,)-314.5(p)]TJ /F7 1 Tf 5.8385 0 TD (=)Tj /F3 1 Tf 0.5406 0 TD [(0.)15.9(06)21.2(\).)]TJ -8.1887 -1.0527 TD [(A)-425.8(c)0(o)20.8(m)0(p)18.1(a)0(r)13.5(i)0(s)17.7(o)0(n)-411.2(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)-416.2(pa)15.1(ti)16.5(en)20.8(ts)-414.8(wi)14.9(t)13.9(h)-421.9(an)15.1(d)-416.2(w)0(i)14.9(t)0(h)18.9(o)0(u)15.5(t)-418.6(PB)]TJ -1.0015 -1.0755 TD [(wa)16.9(s)-269.4(n)0(o)21.2(t)-264.9(po)15.5(ss)18.8(ib)18.9(le)-254.7(si)17.7(nc)15.1(e)-262.9(o)0(n)15.5(l)0(y)-254.3(t)0(w)20.6(o)-268.2(pa)20.8(ti)16.5(en)15.1(ts)-255.5(di)18.9(d)-262.5(n)0(o)15.5(t)-264.9(sh)20(ow)-255.8(th)18.9(is)]TJ T* [(br)13.9(ea)20.4(th)13.2(i)13.9(n)0(g)-416.9(p)0(a)15.1(t)0(t)16.5(e)0(r)19.2(n)0(.)-416.6(A)-425.8(ne)20.8(ga)15.1(ti)16.5(ve)-411.7(co)15.1(rr)18(el)18.4(at)18.5(io)13.2(n)-421.9(w)0(a)16.9(s)-423.1(fo)13.9(un)21.2(d)-427.6(b)0(e)20.8(-)]TJ T* [(tw)14.9(ee)14.7(n)-450.3(t)0(h)13.2(e)-450.7(oc)15.1(cu)20.8(rr)12.4(en)20.8(ce)-446.2(of)-447(P)11.4(B)-455(an)15.1(d)]TJ /F4 1 Tf 13.9418 0 TD (P)Tj /F3 1 Tf 7.97 0 0 7.97 454.11 675.496 Tm 0.0001 Tc [(a,)18.5(CO)]TJ 7.472 0 0 6.641 470.268 673.852 Tm 0 Tc (2)Tj 9.963 0 0 9.963 478.545 675.496 Tm [(\(t)17.3(he)-445.8(lo)18.9(we)16.9(r)-457.6(t)0(h)18.9(e)]TJ /F4 1 Tf -16.9863 -1.0755 TD (P)Tj /F3 1 Tf 7.97 0 0 7.97 315.269 664.781 Tm 0.0001 Tc [(a,)18.5(CO)]TJ 7.472 0 0 6.641 331.427 663.137 Tm 0 Tc (2)Tj 9.963 0 0 9.963 335.055 664.781 Tm [(,)-205.2(t)0(h)18.9(e)-206(hi)18.9(gh)15.5(er)-197(th)18.9(e)-206(P)11.4(B)-210.3(p)0(e)20.8(r)0(c)19.2(e)0(n)15.1(t)0(a)18.4(g)0(e)15.1(\))0(,)-196.2(a)0(n)20.8(d)-205.6(be)15.1(tw)20.6(ee)14.7(n)-205.6(P)11.4(B)-204.6(a)0(n)15.1(d)]TJ /F4 1 Tf -2.5835 -1.0755 TD (T)Tj /F3 1 Tf 7.97 0 0 7.97 314.759 654.066 Tm 0.0001 Tc [(L,)21.9(CO)]TJ 9.963 0 0 9.963 332.22 654.066 Tm 0 Tc (.)Tj -1.2974 -1.0471 TD [(Th)17.1(e)-388.1(l)0(o)18.9(w)0(e)16.9(r)]TJ /F4 1 Tf 4.5126 0 TD (T)Tj /F3 1 Tf 7.97 0 0 7.97 369.638 643.634 Tm 0.0001 Tc [(L,)21.9(CO)]TJ 9.963 0 0 9.963 391.068 643.634 Tm 0 Tc [(ca)14.7(n)-387.7(h)0(a)20.8(r)0(d)13.9(l)0(y)-373.8(b)0(e)-377.5(t)0(h)13.2(e)-382.4(on)15.5(ly)-379.5(ca)20.4(us)14.4(e)-382.4(o)0(f)-378.7(P)0(B)]TJ -8.2058 -1.0755 TD [(oc)15.1(cu)15.1(rr)18(en)20.8(ce)-207.2(in)-208.8(th)18.9(e)-217.4(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-210(s)0(i)17.7(n)0(c)15.1(e)]TJ /F4 1 Tf 12.2859 0 TD (P)Tj /F3 1 Tf 7.97 0 0 7.97 437.669 632.919 Tm [(a,)18.4(O)]TJ 7.472 0 0 6.641 448.611 631.275 Tm (2)Tj 9.963 0 0 9.963 454.507 632.919 Tm [(du)21.2(ri)17.3(ng)-212.1(da)20.8(yt)18.9(im)15.7(e)-217.4(i)0(s)-210(n)0(o)21.2(t)]TJ -14.5735 -1.0755 TD [(di)13.2(f)20.4(f)0(e)19.2(r)0(e)13.5(n)0(t)-459.2(b)0(e)20.8(t)0(w)14.9(e)0(e)20.4(n)-467.4(pa)15.1(ti)16.5(en)20.8(ts)-460.3(an)15.1(d)-467.4(c)0(o)20.8(n)0(t)18.9(r)0(o)13.9(l)-464.1(su)14.4(bj)18.8(ec)14.7(ts)17.7(,)-467(b)0(u)21.2(t)-469.8(th)18.9(e)]TJ T* [(sl)17.7(ig)13.2(ht)-288.4(hy)15.5(pe)20.8(rv)19.6(en)15.1(ti)16.5(la)18.4(ti)16.5(on)-291.8(ca)20.4(us)20(ed)-292.2(by)-291.8(me)17.7(ch)15.1(an)20.8(or)19.6(ec)14.7(ep)15.1(to)18.8(r)-298.3(s)0(t)17.7(i)0(m)15.7(u)0(-)]TJ T* [(la)12.8(ti)22.2(on)-354.3(an)20.8(d)-359.3(a)]TJ /F4 1 Tf 5.1386 0 TD (P)Tj /F3 1 Tf 7.97 0 0 7.97 366.463 600.775 Tm 0.0001 Tc [(a,)25.6(CO)]TJ 7.472 0 0 6.641 382.62 599.13 Tm 0 Tc (2)Tj 9.963 0 0 9.963 389.934 600.775 Tm [(ne)20.8(ar)13.5(er)-350.7(to)-351(t)13.9(h)0(e)-354.7(a)0(p)20.8(n)0(o)15.5(e)0(a)-349.5(t)0(h)18.8(r)0(e)13.5(s)0(h)20(o)0(l)18.9(d)-359.3(co)15.1(ul)18.8(d)]TJ -8.092 -1.0755 TD [(fa)13.5(ci)18.4(li)16.5(ta)18.4(te)-317.3(th)18.8(e)-325.5(r)0(e)19.2(s)0(p)14.4(i)13.9(ra)13.5(to)18.8(ry)-316.1(co)20.8(nt)13.2(ro)19.6(l)-327.5(i)13.9(ns)14.4(ta)18.4(bi)18.9(li)16.5(ty)81.4(.)]TJ 1.0015 -1.0471 TD [(No)-307.1(ex)15.1(pl)18.9(an)15.1(at)18.5(io)18.9(n)-313.8(f)0(o)14(r)-309.7(th)13.2(e)-314.2(l)0(o)18.9(w)0(e)16.9(r)]TJ /F4 1 Tf 11.8477 0 TD (T)Tj /F3 1 Tf 7.97 0 0 7.97 442.715 579.628 Tm 0.0001 Tc [(L,)21.9(CO)]TJ 9.963 0 0 9.963 463.464 579.628 Tm 0 Tc [(in)-305.5(F)11.4(M)0(S)-304.3(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-306.7(i)0(s)]TJ -15.4726 -1.0755 TD [(ap)15.1(pa)15.1(re)19.2(nt)18.9(:)-367.3(p)0(u)21.2(l)0(m)15.7(o)0(n)15.5(a)0(r)19.2(y)-365(fu)19.6(nc)15.1(ti)16.5(on)-354.3(te)18.4(st)17.7(s)-366.2(w)0(e)16.9(r)0(e)-356.3(n)0(o)21.2(r)0(m)16.5(a)0(l)12.8(;)-361.6(ha)15.1(em)17.7(o-)]TJ T* [(gl)13.2(ob)21.2(in)-356.7(le)18.5(ve)20.8(ls)-357.9(w)12.4(e)0(r)13.5(e)-359.7(si)17.7(mi)15.7(la)18.4(r)-366.6(t)0(o)-351(n)0(o)15.5(r)0(m)16.5(a)0(l)-351.4(s)0(u)14.4(b)0(j)18.9(e)0(c)20.4(t)0(s)-357.9(\()0(w)15.7(h)0(i)18.9(c)0(h)-354.8(e)0(x)20.8(-)]TJ T* [(cl)12.8(ud)21.2(es)-208(th)13.2(e)-217.4(p)0(o)21.2(s)0(s)18.9(i)0(b)13.2(i)0(l)16.5(i)13.9(ty)-208.8(of)-213.7(oc)20.8(cu)15.1(lt)-205.5(bl)13.2(ee)20.4(di)18.9(ng)-212.1(du)21.2(e)-217.4(t)0(o)-214.5(t)13.9(he)-212.5(fr)18(eq)15.1(ue)20.8(nt)]TJ T* [(us)14.4(e)-462.1(o)0(f)-458.4(a)0(n)20.8(t)0(i)16.5(-)0(i)17.3(n)0(f)14(l)0(a)18.5(m)0(m)14.9(a)0(t)18.4(o)0(r)19.6(y)-467.4(dr)19.6(ug)15.5(s\))18.4(;)-464.1(a)0(l)18.5(l)-464.1(pa)15.1(ti)16.5(en)20.8(ts)-460.3(w)12.4(e)0(r)13.5(e)-462.1(no)15.5(n-)]TJ T* [(sm)16.9(ok)15.5(er)19.2(s;)-352.2(an)20.8(d)-359.3(w)12.4(he)15.1(n)-353.6(t)0(h)18.9(e)-359.7(me)17.7(as)19.6(ur)13.9(em)17.7(en)15.1(t)-356(w)0(a)16.9(s)-354.8(no)15.5(rm)16.5(al)18.4(iz)18.4(ed)-349.1(by)]TJ T* [("C)13.6(O)-186.8(b)0(a)20.8(c)0(k)15.1(-)0(t)17.3(e)0(n)20.8(s)0(i)17.7(o)0(n)15.5(")-185.8(\(c)19.2(ar)13.5(bo)21.2(xy)15.5(ha)20.8(em)17.7(og)15.5(lo)18.9(bi)18.8(n)-188.6(\))-184.5(th)18.8(e)-382.4(d)0(a)20.8(t)0(a)-175(d)0(i)13.2(d)-182.9(no)15.5(t)]TJ 0 -1.0698 TD [(ch)15.1(an)15.1(ge)20.8(.)-341.8(C)11.6(he)15.1(st)-329.5(ra)13.5(di)18.9(og)15.5(ra)19.2(ph)21.2(s)-343.4(s)0(e)19.6(e)0(m)-335.1(t)0(o)-334(e)0(x)20.8(c)0(l)18.4(u)0(d)15.5(e)-342.6(an)-332(in)18.9(te)18.4(rs)18.4(ti)16.5(ti)16.5(al)]TJ 0 -1.0755 TD [(re)13.5(in)18.8(fo)19.6(rc)13.5(em)17.7(en)15.1(t)13.9(,)-216.6(al)18.5(th)13.2(ou)21.2(gh)-206.4(th)18.9(is)-210(do)21.2(es)-208(no)15.5(t)-213.7(r)0(u)19.6(l)0(e)-431.1(o)0(u)15.5(t)-213.7(th)13.2(e)-211.7(d)0(i)18.8(s)0(e)13.9(a)0(s)19.6(e)]TJ /F10 1 Tf 22.2045 0 TD (')Tj /F3 1 Tf 0.2106 0 TD (s)Tj -22.4151 -1.0755 TD [(ha)15.1(vi)18.9(ng)-314.5(a)-325.5(v)0(e)15.1(r)0(y)-310.4(e)0(a)14.7(r)0(l)17.3(y)-325.1(pu)21.2(lm)15.7(on)15.5(ar)19.2(y)-325.1(i)0(n)18.8(v)0(o)15.5(l)0(v)18.9(e)0(m)17.7(e)0(n)15.1(t)0(.)]TJ 1.0015 -1.0527 TD [(Th)17.1(e)-519(o)0(v)21.2(e)0(r)13.5(l)13.9(ap)-508.4(of)-503.9(re)13.5(la)18.4(ti)16.5(ve)-502.7(hy)15.5(po)21.2(ca)14.7(pn)21.2(ia)12.8(,)-512.5(h)0(y)21.2(p)0(e)15.1(r)0(v)19.6(e)0(n)15.1(t)0(i)16.5(l)0(a)18.4(t)0(i)16.5(o)0(n)]TJ -1.0015 -1.0755 TD [(an)15.1(d)-427.6(v)0(e)15.1(n)0(t)18.9(i)0(l)16.5(a)0(t)18.5(o)0(r)19.6(y)-433.3(i)13.9(n)0(s)14.4(t)0(a)18.4(b)0(i)18.9(l)0(i)16.5(t)0(y)-419.3(a)0(t)-419.7(s)0(l)17.7(e)0(e)14.7(p)-427.6(on)15.5(se)19.6(t)-429.9(a)0(n)15.1(d)-427.6(du)21.2(ri)17.3(ng)-422.6(th)18.9(e)]TJ T* [(li)16.5(gh)15.5(te)18.4(r)-321(s)0(t)17.7(a)0(g)15.1(e)0(s)-310.4(o)0(f)-310.4(s)0(l)17.7(e)0(e)14.7(p)-319.4(\(p)19.6(os)14.3(si)17.7(bl)18.9(y)-319.4(e)0(n)15.1(h)0(a)20.8(n)0(c)15.1(e)0(d)-309.2(b)0(y)-314.5(p)0(a)20.8(i)0(n)-311.2(r)0(e)13.5(l)0(a)18.4(t)0(e)18.4(d)]TJ T* [(sl)17.7(ee)14.7(p)-319.4(d)0(i)18.9(s)0(r)18.4(u)0(p)15.5(t)0(i)16.5(o)0(n)21.2(\))-321(co)15.1(ul)18.9(d)-319.4(p)0(e)15.1(r)0(h)19.6(a)0(p)15.1(s)-314.9(ex)15.1(pl)18.9(ai)18.4(n)-319.4(t)0(h)13.2(e)-319.8(oc)20.8(cu)15.1(rr)18(en)15.1(ce)-309.6(of)]TJ 0 -1.0698 TD [(PB)-204.6(in)-203.1(F)11.4(M)0(S)-201.9(s)0(u)20(b)0(j)13.2(e)0(c)20.4(t)0(s)17.7(.)-210.9(T)12.2(h)0(e)-201.1(s)0(i)17.7(m)0(i)15.7(l)0(a)12.8(r)0(i)17.3(t)13.9(ie)12.8(s)-206.8(w)0(i)14.9(t)0(h)-203.1(h)0(i)18.8(g)0(h)-200.7(a)0(l)18.5(t)0(i)16.5(t)0(u)18.9(d)0(e)-201.1(P)11.4(B,)]TJ 0 -1.0755 TD [(sh)14.4(or)19.6(t)-475.5(a)0(p)15.1(n)0(o)15.5(e)0(a)20.4(s)0(/)17.7(h)0(y)15.5(p)0(o)21.2(p)0(n)15.5(o)0(e)20.8(a)0(s)13.9(,)-472.7("p)18.3(oo)15.5(r)-474.7(s)0(l)17.7(e)0(e)14.7(p)0(")-465.4(c)0(o)15.1(m)0(p)18.1(l)0(a)18.4(i)0(n)18.8(t)0(s)17.7(,)-478.4(in)18.8(-)]TJ T* [(cr)13.5(ea)20.4(se)13.9(d)-325.1(p)0(e)15.1(r)0(c)19.2(e)0(n)20.8(t)0(a)12.8(g)0(e)-314.9(o)0(f)-316.1(p)0(h)15.5(a)0(s)19.6(e)-331.2(1)-325.1(s)0(l)17.7(e)0(e)20.4(p)-330.8([1)19.6(8],)-327.9(furt)-8.6(her)-340(support)]TJ T* [(the)-340.8(hypoth)-7(esis)-332.6(o)-6.5(f)-332.4(a)-331.2(h)0(y)-7.2(poxic-hypocap)-9.4(nic)-340.8(mecha)-8.2(nism.)]TJ /F6 1 Tf 6.2255 -4.5012 TD [(Limi)-9.2(tation)-9.4(s)-332(o)0(f)-333.2(the)-339.2(study)]TJ /F3 1 Tf -5.2239 -2.6518 TD [(Bo)16.5(th)-254.3(th)18.9(e)-262.9(r)0(e)13.5(d)0(u)21.2(c)0(t)18.4(i)0(o)13.2(n)-262.5(i)13.9(n)-262.5(ga)15.1(s)-263.7(t)0(r)17.3(a)0(n)20.8(s)0(f)18.4(e)0(r)-253.9(a)0(n)15.1(d)-262.5(th)18.8(e)-262.9(o)0(c)20.8(c)0(u)15.1(r)0(r)18(e)0(n)15.1(c)0(e)-252.7(o)0(f)]TJ -1.0015 -1.0755 TD [(PB)-227.4(we)11.2(re)-225.5(un)21.2(ex)15.1(pe)15.1(ct)18.4(ed)-223.9(fi)17.3(nd)15.5(in)18.9(gs)20(,)-239.4(t)0(h)18.8(e)0(r)19.2(e)0(f)13.5(o)0(r)19.6(e)-234.5(th)18.9(e)-240.2(p)0(o)21.2(s)0(s)18.9(i)0(b)13.2(i)0(l)16.5(i)13.9(ty)-231.5(of)-225.1(a)]TJ 0 -1.0698 TD [(su)14.4(bt)18.9(le)-499.4(di)18.9(f)20.4(f)0(u)14(s)0(e)-498.2(l)13.9(un)15.5(g)-507.2(d)0(i)18.9(s)0(e)19.6(a)0(s)13.9(e)-507.6(or)-498.2(pu)21.2(lm)15.7(on)15.5(ar)19.2(y)-507.2(v)0(a)20.8(s)0(c)13.9(u)0(l)18.9(a)0(r)-498.6(d)0(i)18.8(s)0(-)]TJ 0 -1.0755 TD [(tu)13.2(rb)19.6(an)15.1(ce)-400.7(ca)14.7(nn)21.2(ot)-407.9(be)-400.3(ex)15.1(cl)18.4(ud)15.5(ed)20.8(.)-415.8(H)0(i)20.6(g)0(h)-405.6(r)0(e)13.5(s)0(o)20(l)0(u)18.9(t)0(i)16.5(o)0(n)-405.6(c)0(o)20.8(m)0(p)12.4(u)0(t)18.9(e)0(d)]TJ T* [(to)13.2(mo)18.1(gr)19.6(ap)15.1(hy)-343(sc)19.6(an)20.8(s)-354.8(o)0(r)-338.9(p)0(u)15.5(l)0(m)15.7(o)0(n)21.2(a)0(r)13.5(y)-347.9(ha)15.1(em)17.7(od)15.5(yn)21.2(am)17.7(ic)12.8(s)-349.1(a)0(r)19.2(e)-354(ob)21.2(-)]TJ T* [(vi)13.2(ou)21.2(sl)17.7(y)-438.9(n)0(o)15.5(t)-435.6(in)18.9(cl)18.5(ud)15.5(ed)-428.7(in)-430.7(th)18.9(e)-439.3(r)0(o)19.6(u)0(t)18.9(i)0(n)13.2(e)-439.3(as)19.6(se)19.6(ss)18.8(me)12(nt)-425(of)-429.9(th)13.2(es)19.6(e)]TJ T* [(pa)15.1(ti)16.5(en)20.8(ts)-363.6(wh)17.3(o)-370.7(a)0(r)19.2(e)-371.1(ma)17.7(na)15.1(ge)20.8(d)-370.7(b)0(y)-360(r)0(h)19.6(e)0(u)15.1(m)0(a)17.7(t)0(o)18.9(l)0(o)18.9(g)0(i)13.2(s)0(t)17.7(s)-366.2(as)-361.6(ou)15.5(t-)17.3(pa)20.8(-)]TJ T* [(ti)16.5(en)15.1(ts)17.7(.)]TJ 1.0015 -1.0527 TD [(He)11.2(al)18.5(th)18.9(y)-347.9(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)-335.2(w)0(e)11.2(r)0(e)-333.6(s)0(e)14(l)0(e)18.4(c)0(t)18.4(e)0(d)-337.7(a)0(s)-338.9(a)-348.3(co)20.8(nt)13.2(ro)19.6(l)-344.6(g)0(r)13.9(o)0(u)21.2(p)0(.)-336.9(A)0(l)14.9(-)]TJ -1.0015 -1.0698 TD [(th)13.2(ou)21.2(gh)-291.7(th)18.9(ey)-292.2(w)12.4(e)0(r)13.5(e)-297.1(we)16.9(ll)16.5(-m)16.5(at)18.4(ch)15.1(ed)-286.5(wi)14.9(th)-288.4(th)18.8(e)-302.8(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-289.6(i)0(n)-288.4(t)0(e)18.4(r)0(m)16.5(s)]TJ 0 -1.0755 TD [(of)-190.9(ag)15.1(e,)-189.3(se)19.6(x,)-188.9(BM)14.6(I,)-190.5(an)15.1(d)-199.9(r)0(e)19.2(s)0(p)20(i)0(r)17.3(a)0(t)12.8(o)0(r)19.6(y)-199.9(fu)19.6(nc)15.1(ti)16.5(on)21.2(,)-199.6(t)0(h)18.9(e)-200.3(re)19.2(su)14.3(lt)16.5(s)-195.4(c)0(o)15.1(u)0(l)18.8(d)]TJ T* [(ha)15.1(ve)-354.8(be)20.8(en)-354.8(di)18.9(f)20.4(f)0(e)13.5(r)0(e)19.2(n)0(t)-351(h)0(a)15.1(d)-359.3(ma)17.7(tc)18.4(he)15.1(d)-359.3(c)0(o)15.1(n)0(t)18.9(r)0(o)19.6(l)-361.7(su)14.4(bj)18.9(ec)20.4(ts)-357.9(fr)18(om)-351.8(a)]TJ T* [(cl)12.8(in)18.9(ic)18.4(al)-453.9(po)15.5(pu)15.5(la)18.4(ti)16.5(on)-451.1(be)15.1(en)-457.2(ch)20.8(os)14.4(en)20.8(.)-467(T)12.2(he)-457.2(pr)14(ev)20.8(al)18.5(en)15.1(ce)-457.6(of)-452.7(PB)]TJ T* [(wo)17.3(ul)13.2(d)-239.8(p)0(r)19.6(o)0(b)15.5(a)0(b)15.1(l)0(y)-231.5(n)0(o)21.2(t)-247.8(be)-229.6(af)24.9(fe)19.2(ct)18.5(ed)15.1(,)-239.4(b)0(u)15.5(t)-242.1(a)-240.2(h)0(i)13.2(g)0(h)21.2(e)0(r)-236.8(p)0(e)20.8(r)0(c)13.5(e)0(n)20.8(t)0(a)18.4(g)0(e)-235.2(o)0(f)]TJ T* [(li)16.5(gh)15.5(t)-447(s)0(l)17.7(e)0(e)14.7(p)-444.6(st)17.7(ag)15.1(es)-441.3(co)20.8(ul)18.9(d)-450.3(b)0(e)-440.1(h)0(y)15.5(p)0(o)21.2(t)0(h)18.8(e)0(s)13.9(i)0(z)18.4(e)0(d)-440.1(i)0(n)-436.4(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-443.3(a)0(f)19.2(-)]TJ T* [(fe)13.5(ct)18.4(ed)-314.9(by)-314.5(a)-325.5(d)0(i)18.9(s)0(e)13.9(a)0(s)19.6(e)-325.5(ca)20.4(us)14.4(in)18.9(g)-325.1(a)-319.8(ch)15.1(ro)19.6(ni)13.2(c)-319.8(p)0(a)15.1(i)0(n)18.9(.)]TJ 1.0015 -1.0471 TD [(Th)17.1(e)-262.9(u)0(s)20(e)-262.9(of)-253.5(be)15.1(nz)20.8(od)15.5(ia)18.4(ze)20.4(pi)13.2(ne)20.8(s)-263.7(a)0(t)-249(l)0(o)13.2(w)-260.8(do)21.2(sa)13.9(ge)-252.3(in)-254.3(t)13.9(w)0(o)-255.8(o)0(f)-253.5(t)0(h)18.9(e)]TJ -1.0015 -1.0755 TD [(pa)15.1(ti)16.5(en)20.8(ts)-238.4(wa)16.9(s)-246.7(s)0(t)17.7(o)0(p)21.2(p)0(e)15.1(d)-245.5(tw)20.6(o)-245.5(w)0(e)16.9(e)0(k)15.1(s)-241(be)15.1(fo)19.6(re)-236.8(th)13.2(e)-240.2(s)0(t)17.7(u)0(d)15.5(y)73.2(.)-245.1(B)0(o)16.5(t)0(h)-237.2(p)0(a)20.8(-)]TJ T* [(ti)16.5(en)15.1(ts)-238.4(di)13.2(d)-245.5(n)0(o)15.5(t)-253.5(re)19.2(po)21.2(rt)-244.5(a)-251.6(c)0(h)20.8(a)0(n)15.1(g)0(e)-240.9(i)0(n)-242.9(s)0(u)20(b)0(j)13.2(e)0(c)20.4(t)0(i)16.5(v)0(e)-240.9(q)0(u)15.5(a)0(l)18.5(i)0(t)16.5(y)-251.2(of)-236.4(sl)17.7(ee)14.7(p)]TJ T* [(an)15.1(d)-416.2(i)0(t)-404.6(s)0(e)13.9(e)0(m)17.7(s)-417.4(di)18.9(f)20.4(f)0(i)17.3(c)0(u)15.1(l)0(t)-404.6(t)0(o)-407.9(e)0(x)15.1(p)0(l)18.8(a)0(i)18.5(n)-416.2(an)15.1(y)-410.5(o)0(f)-412.8(t)13.9(he)-411.6(re)19.2(su)20(lt)16.5(s)-417.4(a)0(s)-407.2(a)]TJ T* [(re)13.5(bo)21.2(un)15.5(d)-325.1(e)0(f)30.6(f)0(e)13.5(c)0(t)-311.6(o)0(f)-316.1(t)0(h)18.9(e)-325.5(wi)14.9(th)18.9(dr)13.9(aw)16.9(al)18.4(.)]TJ ET 1 i 58.28 749.367 227.168 -0.51 re f 58.28 732.926 227.168 -0.51 re f 58.28 688.082 227.168 -0.51 re f BT /F2 1 Tf 8.966 0 0 8.966 58.28 772.667 Tm [(Table)-331.9(4.)-336.7(\261)-333.2(Spearman)-276.5(rank)-269.6(correlation)-276(between)-274.9(the)-277.9(occur-)]TJ 0 -1.0559 TD [(rence)-571.2(of)-570.7(periodic)-569.5(breathing)-572.7(and)-569.6(sleep,)-569.6(laboratory)-576.2(and)]TJ T* [(functional)-332.2(data)]TJ /F3 1 Tf 0 -1.7072 TD [(%)-335.1(Periodic)-334.9(breathing)]TJ /F4 1 Tf 8.8521 0 TD (versus)Tj /F3 1 Tf 6.4304 0 TD [(r)-3585.6(p-value)]TJ /F4 1 Tf -15.2825 -2.0044 TD (T)Tj /F3 1 Tf 7.173 0 0 7.173 63.213 720.453 Tm (L,CO)Tj 8.966 0 0 8.966 82.318 720.453 Tm (mmol)Tj /F9 1 Tf 2.3079 0.2213 TD (.)Tj /F3 1 Tf 0.2719 -0.2213 TD (min)Tj 6.725 0 0 5.977 119.282 724.479 Tm (-1)Tj /F9 1 Tf 8.966 0 0 8.966 124.838 722.438 Tm (.)Tj /F3 1 Tf 0.2656 -0.2213 TD (kPa)Tj 6.725 0 0 5.977 140.598 724.479 Tm (-1)Tj 8.966 0 0 8.966 188.957 720.453 Tm [(-0.62)-3321.4(0.01)]TJ -14.5743 -1.0559 TD (Daytime)Tj /F4 1 Tf 3.7368 0 TD (P)Tj /F3 1 Tf 7.173 0 0 7.173 97.228 710.986 Tm (a,CO)Tj 6.725 0 0 5.977 112.082 709.512 Tm (2)Tj 8.966 0 0 8.966 118.431 710.986 Tm [(kPa)-6376.7(-0.50)-3321.4(0.05)]TJ -6.7086 -1.0559 TD [(DEF)-332.6(total)-339.5(number)-7416.3(0.76)-3226.1(0.001)]TJ T* (DEF)Tj /F9 1 Tf 1.8779 0.2276 TD (.)Tj /F3 1 Tf 0.2656 -0.2276 TD (h)Tj 6.725 0 0 5.977 81.978 696.075 Tm (-1)Tj 8.966 0 0 8.966 190.431 692.05 Tm [(0.62)-3479(0.01)]TJ /F4 1 Tf -14.7387 -1.606 TD (T)Tj /F3 1 Tf 7.173 0 0 7.173 63.213 677.65 Tm (L,CO)Tj 8.966 0 0 8.966 79.313 677.65 Tm [(:)-292.7(transfer)-292.8(factor)-298(of)-290.8(the)-291.5(lung)-291.2(for)-297.6(carbon)-288.3(monoxide;)]TJ /F4 1 Tf 20.0752 0 TD (P)Tj /F3 1 Tf 7.173 0 0 7.173 264.756 677.65 Tm (a,CO)Tj 6.725 0 0 5.977 279.609 676.12 Tm (2)Tj 8.966 0 0 8.966 283.011 677.65 Tm (:)Tj -25.064 -1.0559 TD [(arterial)-282.5(blood)-278.1(carbon)-275.7(dioxide)-279.2(pressure;)-273.5(DEF:)-277.6(desaturation)-280.7(event)]TJ T* [(frequency)60.2(.)]TJ ET 58.28 246.501 227.168 -0.51 re f 171.836 231.534 73.02 -0.283 re f 58.28 215.15 227.168 -0.51 re f 58.28 151.37 227.168 -0.51 re f BT /F2 1 Tf 8.966 0 0 8.966 58.28 279.269 Tm [(Table)-331.9(5.)-336.7(\261)-333.2(Comparison)-252.5(of)-254.5(laboratory,)-257.3(functional)-250(and)-253.5(sleep)]TJ T* [(related)-355.3(data)-351.8(in)-355.5(17)-350.2(fibromyalgia)-354.7(syndrome)-355.4(\(FMS\))-357.1(patients)]TJ T* [(stratified)-487.2(according)-487.9(to)-488.5(the)-486.5(reported)-491.3(complaint)-484(of)-488.5(hyper-)]TJ T* (somnolence)Tj 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