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[(asses)-8.2(s)-286.5(agreement)-294.4(betw)-9.8(een)-287.6(two)-287.4(met)-8.2(hods)-288.8(of)-287.7(clin)-8.2(ical)-287.5(meas)-8.2(-)]TJ 0 -1.0527 TD [(urem)-8.2(ent.)-398.1(It)-392.5(calcul)-10.6(ates)-394.4(lim)-10.2(its)-395.2(of)-395.8(agreem)-10.5(ent)-397.7(based)-398.5(on)-394.2(the)]TJ 0 -1.0471 TD [(mean)-445.2(difference)-437.5(and)-440.9(the)-443.2(stand)-7.8(ard)-442.5(deviation)-447.3(of)-441.3(the)-437.6(dif-)]TJ 0 -1.0527 TD [(ference)-10.1(s.)-321(The)-319.8(limit)-10.8(s)-314.9(o)0(f)-321.8(agreem)-10.5(ent)-323.7(can)-321.8(be)-320.6(used)-323.3(to)-316.9(predi)-8.2(ct)]TJ 0 -1.0471 TD [(whether)-218.9(clinically)-214.2(signi)-9.8(ficant)-210.9(differences)-211.8(in)-208.8(PEF)-209.7(are)-215.2(likely)]TJ 0 -1.0528 TD [(to)-191.7(occur)45(.)-188.2(A)-192.5(Student)]TJ /F7 1 Tf 7.4945 0 TD (')Tj /F3 1 Tf 0.2219 0 TD [(s)-189.7(t-test)-197(was)-189.9(perfor)-9.8(med)-193.6(to)-191.7(determin)-10.7(e)-189(the)]TJ -7.7164 -1.0471 TD [(signifi)-9.6(cance)-341.2(of)-333.2(the)-335.1(differences.)]TJ 1.0015 -1.0528 TD [(Th)17.1(re)19.2(e)-473.5(o)0(f)-464.1(t)0(h)18.9(e)-473.5(au)15.1(th)18.9(or)19.6(s)-474.3(i)0(n)18.9(d)0(i)18.9(v)0(i)13.2(d)0(u)21.2(a)0(l)18.4(l)0(y)-464.8(e)0(x)15.1(a)0(m)17.7(i)0(n)18.9(e)0(d)-462.9(t)0(h)13.2(e)-467.8(PE)17.9(F)]TJ -1.0015 -1.0471 TD [(re)19.2(co)15.1(rd)19.6(s)-286.5(p)0(r)19.6(o)0(d)15.5(u)0(c)20.8(e)0(d)-275.1(b)0(y)-274.7(t)0(h)18.9(e)-285.7(pa)20.8(ti)16.5(en)15.1(t)13.9(s)-286.5(be)20.8(tw)14.9(ee)14.7(n)-279.6(t)0(h)18.9(e)-285.7(fi)17.3(rs)18.4(t)-282(a)0(n)15.1(d)-279.6(th)13.2(e)]TJ 0 -1.0528 TD [(se)19.6(co)15.1(nd)-251.9(vi)18.9(si)17.7(t.)-253.9(T)12.2(h)0(e)-252.3(r)0(e)13.5(c)0(o)20.8(r)0(d)13.9(s)-258(we)16.9(re)-253.9(pl)18.9(ot)18.9(te)18.4(d)-262.5(a)0(s)-253.5(m)0(a)17.7(x)0(i)18.9(m)0(u)12.4(m)13.2(,)-262.1(m)0(e)17.7(a)0(n)]TJ 0 -1.0471 TD [(an)15.1(d)-222.7(m)0(i)15.7(n)0(i)18.9(m)0(u)12.4(m)-225.8(fo)13.9(r)-224.3(e)0(a)14.7(c)0(h)-218.2(d)0(a)20.8(y)-228.4(\(f)18(ig)13.2(.)-222.3(1)0(\))-230.7(and)-241.7(examined)-246.2(for)-238.8(signs)]TJ 25.1977 66.1583 TD [(of)-230.7(change)-233.4(in)-231.5(PEF)-226.8(like)-8.2(ly)-231.5(to)-225.8(be)-229.6(due)-230.3(to)-231.5(lack)-228.2(of)-230.7(effort,)-223.1(such)-232.3(as)]TJ 0 -1.0471 TD [(an)-286.5(initial)-285.1(fall)-288.7(in)-282.7(PEF)-278(o)-6.5(ver)-283.1(the)-283.9(first)-286.1(few)-281.4(days)-283.5(of)-282(the)-283.9(record)]TJ 0 -1.0528 TD [(reachi)-9.8(ng)-473.9(a)-467.8(plate)-9.4(au)-468.6(for)-472.1(the)-471.7(rema)-8.6(inder)-474.8(or)-469.7(a)-473.5(gradual)-476.7(de-)]TJ 0 -1.0471 TD [(teri)-9.8(oration)-364.9(in)-356.7(PEF)-357.7(over)-357.9(the)-363.6(whole)-363.3(record.)-361.8(Records)-366.5(were)]TJ 0 -1.0528 TD [(den)-8.4(oted)-216.4(as)-219.4(having)-217.9(e)-6.9(ither)-221.1(signs)-219.1(of)-219.4(a)-211.7(p)-6.5(attern)-222.3(of)-213.7(deter)-8.6(ioration)]TJ 0 -1.0471 TD [(in)-402.3(PEF)-397.5(over)-403.4(their)-403.2(length)-402.4(or)-395.8(no)-399.9(pattern)-405.2(of)-395.8(deter)-8.6(ioration,)]TJ 0 -1.0528 TD [(wher)-9(e)-234.5(PEF)-238.2(varie)-8.6(d)-234.1(random)-9.7(ly)-237.2(throu)-7.8(ghout)-239.5(the)-238.4(record)-8.6(.)-233.7(When)]TJ 0 -1.0471 TD [(author)-9(s)-332(did)-340.4(not)-334.7(agree,)-342.7(a)-331.2(majo)-9(rity)-333.8(opini)-8.6(on)-331.6(prevai)-9.4(led.)]TJ 1.0015 -1.0527 TD [(Th)17.1(e)-285.7(s)0(e)13.9(r)0(i)17.3(a)0(l)-271.8(P)0(E)17.9(F)-284.5(re)13.5(ad)20.8(in)18.9(gs)-275.9(we)16.9(re)-276.7(al)18.5(so)-275.9(an)15.1(al)18.5(ys)20(ed)-275.1(st)12(at)18.4(is)17.7(ti)16.5(ca)20.4(ll)16.5(y)]TJ -1.0015 -1.0527 TD [(by)-269(fi)11.6(t)13.9(t)0(i)16.5(n)0(g)-269(a)-280(le)18.4(as)13.9(t)-276.3(s)0(q)14.3(u)0(a)20.8(r)0(e)13.5(s)-275.1(li)16.5(ne)15.1(ar)-265.3(tr)11.6(en)20.8(d)-279.6(l)0(i)16.5(n)0(e)-269.4(t)0(h)18.9(r)0(o)19.6(u)0(g)15.5(h)-279.6(th)18.9(e)-280(P)11.4(EF)]TJ 0 -1.0471 TD [(da)15.1(ta)18.4(.)-296.3(A)0(n)17.3(a)0(l)18.4(y)0(s)20(i)0(s)-289.6(o)0(f)-282(v)0(a)15.1(r)0(i)17.3(a)0(n)15.1(c)0(e)-281.2(w)0(a)16.9(s)-297.9(us)20(ed)-286.5(to)-288.4(de)20.8(te)18.5(rm)16.5(in)13.2(e)-291.4(t)0(h)18.8(e)-297.1(st)17.7(at)18.4(-)]TJ 0 -1.0528 TD [(is)17.7(ti)16.5(ca)14.7(l)-321.8(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(c)0(e)-315.3(o)0(f)-316.1(a)0(n)20.8(y)-325.1(tr)17.3(en)15.1(d)-319.4(d)0(e)15.1(t)0(e)18.4(c)0(t)18.4(e)0(d)15.1(.)]TJ 1.0015 -1.0471 TD [(A)-272.2(s)0(u)14.3(b)0(g)21.2(r)0(o)14(u)0(p)-257.6(o)0(f)-259.2(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-261.2(p)0(a)15.1(r)0(t)17.3(i)0(c)18.4(i)0(p)18.9(a)0(t)12.8(i)0(n)18.9(g)-268.2(in)-260(th)18.8(e)-274.3(s)0(t)17.7(u)0(d)21.2(y)-273.9(w)12.4(h)0(o)15.5(s)0(e)]TJ -1.0015 -1.0527 TD [(ne)15.1(xt)-362.4(ro)13.9(ut)18.9(in)18.8(e)-376.7(c)0(l)18.4(i)0(n)18.9(i)0(c)-362.8(a)0(p)15.1(p)0(o)15.5(i)0(n)18.9(t)0(m)15.7(e)0(n)20.8(t)-373(oc)15.1(cu)15.1(rr)18(ed)-360.4(wi)14.9(th)18.9(in)-368.1(th)18.8(e)-376.8(n)0(e)20.8(x)0(t)]TJ 0 -1.0471 TD [(ye)15.1(ar)-248.2(we)16.9(re)-253.9(se)19.6(en)-246.6(wh)17.3(en)-252.3(th)18.9(ey)-252.3(ne)20.8(xt)-248.6(re)13.5(t)13.9(u)0(r)13.9(n)0(e)20.8(d)-262.5(t)13.9(o)-262.5(cl)18.4(in)18.8(ic)-249(an)15.1(d)-256.8(w)0(e)16.9(r)0(e)]TJ 0 -1.0527 TD [(as)13.9(ke)20.8(d)-256.8(t)0(o)-254.3(r)0(e)19.2(p)0(e)15.1(a)0(t)-249(a)-257.2(th)18.9(ir)17.3(d)-256.8(s)0(e)13.9(r)0(i)17.3(e)0(s)-247.8(o)0(f)-247.8(P)0(E)17.9(F)-256.1(me)12(as)19.6(ur)19.6(em)12(en)20.8(ts)-249.8(as)-247.8(pe)15.1(r)20.4(-)]TJ 0 -1.0471 TD [(fo)13.9(rm)16.5(ed)-474.3(at)-476.6(th)18.9(e)-484.9(s)0(e)19.6(c)0(o)15.1(n)0(d)-473.8(v)0(i)18.9(s)0(i)17.7(t)0(.)-475.8(T)0(h)17.1(e)0(s)19.6(e)-484.9(re)19.2(ad)15.1(in)18.9(gs)-475(we)16.9(re)-475.8(ag)15.1(ai)18.4(n)]TJ 0 -1.0528 TD [(co)15.1(mp)18.1(ar)13.5(ed)-189.7(to)-191.7(th)18.9(e)-200.3(e)0(n)15.1(c)0(o)20.8(u)0(r)14(a)0(g)20.8(e)0(d)-195.4(P)11.4(EF)-192.6(va)15.1(l)13.9(u)0(e)-195.4(a)0(s)-190.9(d)0(e)15.1(s)0(c)19.6(r)0(i)17.3(b)0(e)15.1(d)-199.9(ab)20.8(ov)15.5(e.)]TJ /F5 1 Tf 9.8617 -2.9022 TD [(Res)-7.8(ults)]TJ /F3 1 Tf -8.8602 -2.0998 TD [(Fo)16.3(rt)17.3(y-)13.9(fo)19.6(ur)-435.6(pa)20.8(ti)16.5(en)15.1(ts)-431.9(ag)20.8(re)13.5(ed)-434.4(to)-430.7(pa)15.1(rt)17.3(ic)18.5(ip)18.9(at)18.4(e)-445(i)0(n)-430.7(t)0(h)13.2(e)-439.3(st)17.7(ud)15.5(y)73.2(.)]TJ -1.0015 -1.0471 TD [(T)69.1(w)0(e)16.9(n)0(t)18.9(y)0(-)14(e)0(i)18.5(g)0(h)21.2(t)-401.5(su)20(f)14.7(f)0(e)19.2(r)0(e)19.2(d)-399.1(wi)14.9(th)-390.9(as)19.6(th)13.2(ma)17.7(,)-398.7(1)0(0)-388.5(w)0(i)14.9(t)0(h)-390.9(c)0(h)20.8(r)0(o)13.9(n)0(i)18.9(c)-399.5(ai)18.5(r)20.4(-)]TJ 0 -1.0528 TD [(fl)17.3(ow)-455(li)16.5(m)13.2(i)0(t)16.5(a)0(t)12.8(i)13.9(on)-451.1(an)15.1(d)-456(s)0(i)17.7(x)-461.7(w)12.4(i)0(t)16.5(h)-461.7(no)21.2(no)15.5(bs)20(tr)17.3(uc)15.1(ti)16.5(ve)-445.8(ch)15.1(es)19.6(t)-458.4(p)0(a)15.1(t)0(h)18.8(-)]TJ 0 -1.0471 TD [(ol)13.2(og)21.2(y)73.2(.)-398.7(Th)17.1(e)-399.5(m)0(e)17.7(a)0(n)-394.6(a)0(g)20.8(e)-399.5(wa)16.9(s)-400.3(4)0(9)-388.5(y)0(r)13.9(s)-394.6(\(r)12.3(an)20.8(ge)-388.9(18)15.5(\2616)15.5(5)-399.1(y)0(r)19.6(s)0(\))18.4(;)-401.5(26)]TJ 0 -1.0528 TD [(\(5)13.9(3%)18.9(\))-258.4(w)0(e)16.9(r)0(e)-248.2(m)0(a)17.7(l)0(e)18.5(s)0(.)-247(T)0(h)17.1(e)-257.2(me)17.7(an)-252.3(nu)21.2(mb)18.1(er)-248.2(of)-247.8(PE)17.9(F)-261.7(r)0(e)19.2(a)0(d)20.8(i)0(n)13.2(g)0(s)-247.4(p)0(e)20.8(r)]TJ 0 -1.0471 TD [(da)15.1(y)-222.7(w)0(a)16.9(s)-223.9(7.)21.6(8,)-217.4(an)20.8(d)-222.7(t)0(h)13.2(e)-223.1(nu)21.2(mb)18.1(er)-219.8(of)-213.7(da)20.8(ys)-213.3(wi)14.9(th)-214.5(at)-214.9(le)18.4(as)13.9(t)-219.4(f)0(o)14(u)0(r)-213.7(P)11.4(EF)]TJ 0 -1.0528 TD [(re)13.5(ad)20.8(in)13.2(gs)-566.1(wa)16.9(s)-576.7(9)0(5)15.5(.)0(7)15.9(%)0(.)-566.9(T)0(h)17.1(e)0(r)19.2(e)-581.6(wa)16.9(s)-576.7(v)0(e)15.1(r)0(y)-566.5(l)0(i)16.5(t)0(t)16.5(l)0(e)-567.7(d)0(i)18.9(f)14.7(fe)19.2(re)19.2(nc)15.1(e)]TJ T* [(be)15.1(tw)14.9(ee)20.4(n)-251.2(t)0(h)18.8(e)-251.6(fi)17.3(rs)12.8(t)-247.8(v)0(i)13.2(s)0(i)17.7(t)-247.8(PE)17.9(F)-250.4(r)0(e)13.5(a)0(d)20.8(i)0(n)13.2(g)0(s)-241.7(p)0(e)20.8(r)0(f)18(o)0(r)13.9(m)0(e)17.7(d)-251.2(fo)19.6(r)-252.7(t)0(r)17.3(a)0(i)12.8(n)0(i)18.9(n)0(g)]TJ 0 -1.0471 TD [(wi)14.9(th)-248.6(th)18.9(e)-257.2(d)0(o)15.5(c)0(t)18.5(o)0(r)-247.8(a)0(n)20.8(d)-256.8(th)18.9(os)14.4(e)-257.2(p)0(e)20.8(r)0(f)18(o)0(r)13.9(m)0(e)17.7(d)-256.8(fo)19.6(r)-258.4(c)0(h)20.8(e)0(c)14.7(k)0(i)18.9(n)0(g)-246.2(w)0(i)14.9(t)0(h)-248.6(t)0(h)18.9(e)]TJ 0 -1.0528 TD [(te)12.8(ch)20.8(ni)18.9(ci)12.8(an)20.8(,)-455.6(w)12.4(it)16.5(h)-456(a)-450.7(me)12(an)-440.1(di)13.2(f)20.4(f)0(e)19.2(r)0(e)13.5(n)0(c)20.8(e)-456.4(of)-441.3(-2)14(.3)-445(L)]TJ /F6 1 Tf 18.5341 0.2049 TD (.)Tj /F3 1 Tf 0.2731 -0.2049 TD [(mi)15.7(n)]TJ 7.472 0 0 6.641 511.767 454.28 Tm (-1)Tj 9.963 0 0 9.963 522.312 449.801 Tm [(an)15.1(d)]TJ ET 0 0 0 1 K 0 J 0 j 0.5 w 3.864 M []0 d /GS3 gs 1 i 343.941 217.642 m 535.815 217.642 l 516.565 217.642 m 516.565 215.517 l 529.19 217.642 m 529.19 215.517 l 503.815 217.642 m 503.815 215.517 l 491.065 217.642 m 491.065 215.517 l 478.19 217.642 m 478.19 215.517 l 465.566 217.642 m 465.566 215.517 l 452.816 217.642 m 452.816 215.517 l 439.691 217.767 m 439.691 215.517 l 426.566 217.642 m 426.566 215.517 l 414.191 217.642 m 414.191 215.517 l 401.441 217.642 m 401.441 215.517 l 388.566 217.642 m 388.566 215.517 l 375.566 217.642 m 375.566 215.517 l 362.191 217.642 m 362.191 215.517 l 350.066 217.642 m 350.066 215.517 l 339.816 217.392 m 339.816 345.267 l 339.691 324.392 m 337.441 324.392 l 339.691 345.085 m 337.441 345.085 l 339.691 303.267 m 337.441 303.267 l 339.691 280.767 m 337.441 280.767 l 339.691 257.892 m 337.441 257.892 l 339.691 237.892 m 337.441 237.892 l 339.816 217.642 m 337.441 217.642 l S BT /F13 1 Tf 10 0 0 10 347.555 206.767 Tm 0 0 0 1 k /GS4 gs [(3)-2120.2(5)-2116.7(7)-2052(9)-1978(1)60(1)-1619.6(13)-1654(15)-1623.2(17)]TJ 7.2262 -1.1375 TD [(T)18(ime days)]TJ -9.7 1.825 TD (580)Tj 0 2.0342 TD (600)Tj 0 1.9977 TD (620)Tj 0 2.2818 TD (640)Tj 0 2.2533 TD (660)Tj 0 2.117 TD (680)Tj 0 2.0535 TD (700)Tj 0 10 -10 0 318.566 257.892 Tm (PEF L\341min)Tj 0 8 -8 0 315.732 298.452 Tm (-1)Tj 10 0 0 10 311.816 344.517 Tm (b\))Tj ET /GS3 gs 343.316 349.017 m 381.441 349.017 l 343.385 350.96 m 343.385 347.21 l 381.388 350.936 m 381.388 347.186 l 407.132 348.891 m 471.066 348.891 l 407.2 350.835 m 407.2 347.085 l 471.012 350.811 m 471.012 347.061 l 496.324 348.982 m 535.315 348.982 l 496.393 350.925 m 496.393 347.175 l 535.262 350.901 m 535.262 347.151 l S BT 10 0 0 10 512.44 351.767 Tm /GS4 gs (W)Tj -7.4803 0.0056 TD (W)Tj -8.05 0 TD (W)Tj ET 3.864 M [1 1 ]0 d /GS3 gs 349.691 332.267 m 361.816 345.017 l 389.191 301.892 l 416.816 302.017 l 428.816 291.642 l 440.566 291.767 l 453.066 302.142 l 465.441 291.892 l 477.316 302.392 l 492.565 302.392 l 504.44 281.142 l 517.19 302.767 l 529.44 291.642 l S []0 d 535.565 270.142 m 524.19 270.142 l 524.19 276.267 l 511.69 276.267 l 511.69 269.642 l 495.565 269.642 l 495.565 277.392 l 484.065 277.392 l 484.065 285.392 l 471.941 285.392 l 471.941 277.392 l 460.066 277.392 l 460.066 283.517 l 447.066 283.517 l 447.066 275.517 l 433.816 275.517 l 433.816 278.767 l 421.066 278.767 l 421.066 269.392 l 408.566 269.392 l 408.566 278.017 l 395.316 278.017 l 395.316 284.267 l 382.066 284.267 l 382.066 292.767 l 369.941 292.767 l 369.941 302.642 l 356.691 302.642 l 356.691 312.142 l 343.566 312.142 l S [4 4 ]0 d 350.566 290.267 m 363.441 269.517 l 376.316 269.517 l 414.566 238.017 l 427.691 258.517 l 440.691 249.017 l 453.691 249.017 l 465.941 259.267 l 480.44 259.017 l 492.69 248.642 l 530.565 248.642 l S []0 d 349.566 389.641 m 363.191 395.266 l 387.441 389.141 l 414.316 394.891 l 428.316 389.391 l 453.691 392.641 l 465.316 389.391 l 491.69 392.766 l 504.815 388.641 l 518.69 393.266 l 531.94 389.266 l S 3.864 M 346.816 382.458 m 535.815 382.458 l 516.565 382.458 m 516.565 380.333 l 529.19 382.458 m 529.19 380.333 l 503.815 382.458 m 503.815 380.333 l 491.065 382.458 m 491.065 380.333 l 478.19 382.458 m 478.19 380.333 l 465.566 382.458 m 465.566 380.333 l 452.816 382.458 m 452.816 380.333 l 439.691 382.583 m 439.691 380.333 l 426.566 382.458 m 426.566 380.333 l 414.191 382.458 m 414.191 380.333 l 401.441 382.458 m 401.441 380.333 l 388.566 382.458 m 388.566 380.333 l 375.566 382.458 m 375.566 380.333 l 362.191 382.458 m 362.191 380.333 l 350.066 382.458 m 350.066 380.333 l S BT 0 10 -10 0 319.066 361.787 Tm /GS4 gs (Diurnal variation)Tj 1.5482 -1 TD ( % pred)Tj ET 3.864 M /GS3 gs 344.691 405.141 m 344.691 382.141 l 344.691 382.391 m 342.316 382.391 l 344.691 404.936 m 342.316 404.936 l S BT 10 0 0 10 332.316 400.948 Tm /GS4 gs (20)Tj 0.45 -2.2488 TD (0)Tj -2.45 4.7682 TD -0.0038 Tc (a\))Tj /F3 1 Tf 7.97 0 0 7.97 309.316 180.34 Tm 0 g /GS2 gs 0 Tc 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[(ha)15.1(d)-325.1(r)0(e)19.2(c)0(o)15.1(v)0(e)20.8(r)0(e)13.5(d)-319.4(by)-314.5(th)13.2(e)-319.8(s)0(e)13.9(c)0(o)20.8(n)0(d)-314.5(c)0(l)12.8(i)0(n)18.9(i)0(c)-317.3(v)0(i)18.9(s)0(i)17.7(t)0(.)]TJ 1.0015 -1.0527 TD [(Th)17.1(er)13.5(e)-382.4(w)0(a)16.9(s)-388.9(no)-377.1(si)17.7(gn)15.5(i)13.9(f)0(i)11.6(c)0(a)20.4(n)0(t)-379.5(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nc)20.8(e)-388.1(i)0(n)-379.5(m)0(e)17.7(a)0(n)-377.5(P)11.4(EF)-380.4(di)18.9(f-)]TJ -1.0015 -1.0471 TD [(fe)13.5(re)19.2(nc)15.1(e)-501.9(w)0(h)17.3(e)0(n)-491.3(c)0(o)15.1(m)0(p)18.1(a)0(r)19.2(i)0(n)13.2(g)-501.5(th)18.8(e)-501.9(f)0(i)17.3(r)0(s)18.4(t)-503.9(un)21.2(ob)15.5(se)19.6(rv)13.9(ed)-491.3(wi)14.9(th)-493.3(th)18.9(e)]TJ 0 -1.0527 TD [(en)15.1(co)15.1(ur)19.6(ag)20.8(ed)-258(re)13.5(ad)20.8(in)13.2(g)-262.5(a)0(t)-260.4(v)0(i)18.9(s)0(i)17.7(t)-264.9(2)-268.2(b)0(e)15.1(t)0(w)20.6(e)0(e)14.7(n)-268.2(th)18.9(e)-268.6(3)0(5)-257.6(p)0(a)20.8(t)0(i)16.5(e)0(n)20.8(t)0(s)-261.2(w)0(h)17.3(o)]TJ 0 -1.0471 TD [(ha)15.1(d)-217(u)0(s)20(e)0(d)-212.5(t)13.9(he)-212.5(P)11.4(E)0(F)-209.7(m)0(e)17.7(t)0(e)18.4(r)-218.6(be)15.1(fo)19.6(re)-208.4(vi)18.9(si)17.7(t)-219.4(1)-217(\(m)16.5(ea)14.7(n)-217(-)0(2)19.6(3)0(.)15.9(4)-211.3(L)]TJ /F6 1 Tf 20.1673 0.1992 TD (.)Tj /F3 1 Tf 0.2731 -0.1992 TD [(mi)15.7(n)]TJ 7.472 0 0 6.641 528.038 599.754 Tm (-1)Tj 9.963 0 0 9.963 533.99 595.332 Tm (,)Tj -22.5516 -1.0527 TD [(95)15.5(%)-412.8(C)0(I)-406.2(-)0(1)19.6(6)0(.)15.9(5)-160.1(\261)-154.4(-)0(3)13.9(0)0(.)21.6(4)0(\))-407.2(a)0(n)20.8(d)-416.2(th)18.9(e)-410.9(n)0(i)13.2(n)0(e)-400.3(w)0(h)17.3(o)-416.2(ha)20.8(d)-416.2(n)0(o)21.2(t)-412.9(\(m)16.5(ea)14.7(n)]TJ 0 -1.0471 TD [(-1)48.1(1.)15.9(1)-325.1(L)]TJ /F6 1 Tf 2.9249 0.1992 TD (.)Tj /F3 1 Tf 0.2731 -0.1992 TD [(mi)15.7(n)]TJ 7.472 0 0 6.641 356.258 578.834 Tm (-1)Tj 9.963 0 0 9.963 362.211 574.412 Tm [(,)-324.7(9)0(5)15.5(%)-321.8(CI)-315.1(-2)13.9(.2)-149.1(\261)-154.4(-)0(2)13.9(0)0(.)21.6(0)0(\))13.9(.)]TJ -4.3077 -1.0527 TD [(Ni)14.9(ne)15.1(te)18.4(en)-423(pa)20.8(ti)16.5(en)15.1(ts)-420.5(re)19.2(tu)18.9(rn)13.9(ed)-423(fo)19.6(r)-429.2(a)-433.7(th)18.9(ir)17.3(d)-427.6(c)0(l)12.8(i)13.9(ni)13.2(c)-428(v)0(i)18.9(s)0(i)17.7(t)-429.9(an)15.1(d)]TJ -1.0015 -1.0471 TD [(re)13.5(pe)20.8(at)12.8(ed)-457.2(th)18.9(e)-467.8(s)0(e)19.6(c)0(o)20.8(n)0(d)-462.5(v)0(i)18.9(s)0(i)17.7(t)-464.1(pr)14(oc)20.8(ed)15.1(ur)19.6(e;)-459.6(th)18.8(e)-467.8(m)0(e)17.7(a)0(n)-457.2(d)0(u)21.2(r)0(a)13.5(t)0(i)16.5(o)0(n)]TJ 0 -1.0527 TD [(be)15.1(tw)14.9(ee)20.4(n)-308.1(v)0(i)13.2(s)0(i)17.7(t)0(s)-301(w)12.4(as)-304.7(4.)21.6(7)-308.1(m)0(o)18.1(n)0(t)13.2(h)0(s)-298.6(\()0(r)18(a)0(n)15.1(g)0(e)-297.8(2)0(\261)15.5(1)0(3)-297.4(m)0(o)18.1(n)0(t)13.2(h)0(s)20.1(\))0(.)-298.7(T)0(h)17.1(e)]TJ 0 -1.0471 TD [(me)12(an)-258(ag)20.8(e)-268.6(o)0(f)-259.2(t)0(h)18.9(e)-268.6(su)14.4(bg)21.2(ro)19.6(up)-263.3(w)12.4(a)0(s)-259.2(5)0(0)-257.6(y)0(r)13.9(s)-263.7(\(r)12.4(an)20.8(ge)-258(21)15.5(\2616)21.2(5\))13.9(,)-267.8(6)0(3)21.2(%)]TJ 0 -1.0527 TD [(we)16.9(re)-197(ma)12(l)13.9(e)0(,)-195(1)0(6)-195(s)0(u)14.4(f)20.4(fe)19.2(re)13.5(d)-199.9(f)0(r)12.4(o)0(m)-192.5(a)0(s)13.9(t)0(h)18.9(m)0(a)-198.6(a)0(n)20.8(d)-205.6(th)18.9(re)19.2(e)-206(f)0(r)18(o)0(m)-198.2(c)0(h)20.8(r)0(o)13.9(n)0(i)18.8(c)]TJ 0 -1.0471 TD [(ai)12.8(rf)18(lo)18.9(w)-505.5(l)0(i)22.2(m)0(i)15.7(t)0(a)12.8(t)13.9(io)13.2(n.)-490.5(Th)17.1(e)-501.9(r)0(e)19.2(s)0(u)14.4(l)0(t)16.5(s)-497(of)-498.2(th)18.9(e)-501.9(s)0(u)20(b)0(g)15.5(r)0(o)19.6(u)0(p)-496.6(f)0(o)19.6(r)-503.1(th)18.9(e)]TJ 0 -1.0527 TD [(se)13.9(co)20.8(nd)-314.5(an)15.1(d)-325.1(t)0(h)18.9(i)0(r)17.3(d)-325.1(vi)18.9(si)17.7(ts)-318.1(ar)19.2(e)-325.5(s)0(h)20(o)0(w)17.3(n)-325.1(in)-316.9(ta)18.4(bl)18.9(e)-325.5(1)0(.)]TJ 1.0015 -1.0471 TD [(Fo)16.3(r)-383.6(t)0(h)18.8(e)-382.4(se)19.6(co)15.1(nd)-371.4(vi)18.9(si)17.7(t,)-373.4(si)17.7(gn)21.2(if)17.3(ic)12.8(an)20.8(t)-384.4(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nc)20.8(es)-373(we)16.9(re)-373.4(se)13.9(en)]TJ -1.0015 -1.0527 TD [(be)15.1(tw)14.9(ee)20.4(n)-564.1(t)0(h)18.8(e)-564.5(en)15.1(co)20.8(ur)13.9(ag)20.8(ed)-553.9(va)15.1(lu)18.9(e)-564.5(a)0(n)15.1(d)-558.4(al)12.8(l)-560.8(t)0(h)18.8(e)-564.5(ot)13.2(he)20.8(r)-565.7(P)11.4(EF)]TJ 0 -1.0471 TD [(re)13.5(ad)20.8(in)13.2(gs)20(,)-210.9(a)0(n)20.8(d)-211.3(th)13.2(e)-211.7(m)13.2(ea)14.7(n)-211.3(d)0(e)15.1(c)0(r)19.2(e)0(m)17.7(e)0(n)15.1(t)-208(wa)16.9(s)-212.5(i)0(n)18.8(c)0(r)13.5(e)0(a)20.4(s)0(e)13.9(d)-211.3(co)20.8(mp)18.1(ar)13.5(ed)]TJ 0 -1.0527 TD [(to)-248.6(th)13.2(e)-257.2(s)0(t)17.7(u)0(d)21.2(y)-256.8(gr)13.9(ou)21.2(p)-256.8(a)0(s)-253.5(a)-257.3(w)12.4(h)0(o)15.5(l)0(e)18.4(.)-256.5(Co)16.5(mp)18.1(ar)13.5(is)17.7(on)-246.2(of)-247.8(th)18.8(e)-262.9(f)0(i)17.3(r)0(s)18.4(t)-253.5(an)15.1(d)]TJ 0 -1.0471 TD [(se)13.9(co)20.8(nd)-434(un)21.2(ob)15.5(se)19.6(rv)14(ed)-428.7(P)11.4(E)0(F)-431.7(r)0(e)13.5(a)0(d)20.8(i)0(n)18.9(g)0(s)-435.2(f)0(o)19.6(r)-440.5(th)18.8(e)-439.3(s)0(u)20(b)0(g)15.5(r)0(o)19.6(u)0(p)-434(a)0(l)18.4(s)0(o)]TJ 0 -1.0528 TD [(sh)14.4(ow)17.3(ed)-189.7(a)-206(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)12.8(a)0(n)20.8(t)-202.3(de)15.1(cr)19.2(em)17.7(en)15.1(t;)-194.1(ho)21.2(we)11.2(ve)20.8(r)37.5(,)-199.6(th)18.8(is)-192.9(wa)16.9(s)-206.8(r)0(e)19.2(d)0(u)21.2(c)0(e)14.7(d)]TJ T* [(co)15.1(mp)18.1(ar)13.5(ed)-206.8(to)-214.5(t)13.9(h)0(e)-212.5(d)0(e)15.1(c)0(r)19.2(e)0(m)17.7(e)0(n)15.1(t)-219.4(fo)19.6(un)15.5(d)-217(f)0(o)13.9(r)-218.6(th)18.8(e)-217.4(g)0(r)13.9(o)0(u)21.2(p)-222.7(as)-208(a)-217.4(w)0(h)11.6(o)0(l)18.9(e)0(.)]TJ 1.0015 -1.0471 TD [(Fo)16.3(r)-207.2(t)0(h)18.8(e)-206(th)18.9(ir)17.3(d)-205.6(v)0(i)18.9(s)0(i)17.7(t)-208(th)18.9(er)19.2(e)-206(w)0(e)16.9(r)0(e)-197(n)0(o)-195(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(t)-202.3(di)13.2(f)20.4(f)0(e)19.2(r)0(e)13.5(n)0(c)20.8(e)0(s)-196.6(i)0(n)]TJ -1.0015 -1.0528 TD [(PE)17.9(F)-324.3(r)0(e)19.2(a)0(d)15.1(i)0(n)18.8(g)0(s)-315.7(b)0(e)20.8(t)0(w)14.9(e)0(e)20.4(n)-325.1(th)18.8(e)-319.8(u)0(n)15.5(o)0(b)15.5(s)0(e)19.6(r)0(v)19.6(e)0(d)-314.9(a)0(n)20.8(d)-325.1(ob)21.2(se)13.9(rv)19.6(ed)-314.9(P)11.4(E)0(F)]TJ 0 -1.0471 TD [(re)13.5(ad)20.8(in)13.2(gs)-127.9(co)20.8(mp)12.4(ar)19.2(ed)-127.1(to)-129.1(th)18.8(e)-143.4(e)0(n)20.8(c)0(o)15.1(u)0(r)19.6(a)0(g)15.1(e)0(d)-127.1(P)11.4(EF)-130.1(re)13.5(ad)20.8(in)18.8(g,)-132(al)18.5(th)18.9(ou)15.5(gh)]TJ 0 -1.0528 TD -0.017 Tc [(t)-17(h)-3.8(e)-194.6(m)-17(ea)-17(n)-184(d)-17(ec)-17(re)-17(me)-17(nt)-190.9(w)-17(a)-0.1(s)-195.4(1)-17(0)-183.6(L)]TJ /F6 1 Tf 11.347 0.2049 TD 0 Tc (.)Tj /F3 1 Tf 0.2731 -0.2049 TD [(mi)15.7(n)]TJ 7.472 0 0 6.641 440.164 390.557 Tm (-1)Tj 9.963 0 0 9.963 447.987 386.079 Tm [(fo)19.6(r)-178.8(t)0(h)18.9(e)-177.6(fi)17.3(rs)18.5(t)-179.6(u)0(n)21.2(o)0(b)15.5(s)0(e)19.6(r)0(v)13.9(e)0(d)]TJ -13.9191 -1.0471 TD [(PE)17.9(F)-301.6(r)0(e)13.5(a)0(d)20.8(i)0(n)13.2(g)-296.7(an)15.1(d)-302.4(t)0(h)18.8(e)-302.8(li)16.5(mi)15.7(t)13.9(s)-303.6(of)-293.3(ag)15.1(re)19.2(em)17.7(en)15.1(t)-299.1(s)0(u)14.3(g)0(g)21.2(e)0(s)19.6(t)0(e)12.8(d)-302.4(t)13.9(h)0(a)15.1(t)-299.1(it)]TJ 0 -1.0528 TD [(ma)12(y)-251.2(b)0(e)-246.6(5)0(7)-240.5(L)]TJ /F6 1 Tf 4.9678 0.2049 TD (.)Tj /F3 1 Tf 0.2731 -0.2049 TD [(mi)15.7(n)]TJ 7.472 0 0 6.641 376.611 369.581 Tm (-1)Tj 9.963 0 0 9.963 385.172 365.159 Tm [(be)15.1(l)13.9(o)0(w)-250.2(o)0(r)-242.1(3)0(7)-246.2(L)]TJ /F6 1 Tf 5.5483 0.2049 TD (.)Tj /F3 1 Tf 0.2732 -0.2049 TD [(mi)15.7(n)]TJ 7.472 0 0 6.641 458.249 369.581 Tm (-1)Tj 9.963 0 0 9.963 466.809 365.159 Tm 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[(of)-213.7(th)18.9(e)-223.1(s)0(e)19.6(r)0(i)17.3(a)0(l)-214.9(P)11.4(EF)-215.4(me)17.7(as)19.6(ur)14(em)17.7(en)15.1(ts)-210(ma)17.7(y)-222.7(b)0(e)-212.5(d)0(u)15.5(e)-217.4(to)-214.5(a)-223.1(n)0(u)21.2(m)0(b)12.4(e)0(r)-214.1(o)0(f)]TJ 0 -1.0471 TD [(fa)19.2(ct)12.8(or)19.6(s)-189.7(o)0(t)18.9(h)0(e)15.1(r)-190.1(th)18.9(an)-184(w)12.4(o)0(r)14(s)0(e)19.6(n)0(i)18.9(n)0(g)-183.6(a)0(i)18.4(r)0(w)15.7(a)0(y)15.1(s)-189.7(ob)21.2(st)17.7(ru)13.9(ct)18.4(io)18.9(n,)-177.6(in)13.2(cl)18.4(ud)21.2(in)13.2(g)]TJ 0 -1.0527 TD [(la)18.4(ck)-178.3(of)-173.8(ef)24.9(fo)19.6(rt)17.3(,)-188.2(w)12.4(hi)13.2(ch)-172.7(ma)12(y)-182.9(o)0(c)20.8(c)0(u)15.1(r)-184.5(as)-179.5(so)20(on)-177.9(as)-173.8(th)18.9(e)-189(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)-185.2(le)18.4(av)15.1(es)]TJ 0 -1.0471 TD [(th)18.9(e)-257.2(c)0(l)18.5(i)0(n)18.9(i)0(c)-249(o)0(r)-242.1(m)0(a)12(y)-251.2(oc)15.1(cu)20.8(r)-247.1(g)0(r)19.6(a)0(d)15.1(u)0(a)15.1(l)13.9(ly)-248.6(ov)15.5(er)-242.5(ti)16.5(me)-249.8(aw)16.9(ay)-246.6(fr)18(om)-243.7(th)13.2(e)]TJ 0 -1.0527 TD [(cl)18.4(in)18.9(ic)12.8(,)-484.1(o)0(r)-481.1(f)0(o)19.6(r)-486.1(te)18.4(ch)15.1(ni)18.9(ca)14.7(l)-486.8(r)0(e)19.2(a)0(s)13.9(o)0(n)21.2(s)-485.7(su)14.4(ch)-479.9(as)-475.4(th)18.9(e)-490.6(P)11.4(EF)-477.2(me)12(te)18.4(r)]TJ 0 -1.0471 TD [(st)17.7(ic)18.4(ki)18.9(ng)15.5(.)-284.9(T)0(h)17.1(e)-285.7(la)18.4(ck)-280.8(of)-276.3(ef)24.9(fo)19.6(rt)-278.7(hy)21.2(po)15.5(th)18.9(es)13.9(i)13.9(s)-286.5(is)-278.2(su)14.4(pp)21.2(or)14(te)18.4(d)-285.3(b)0(y)-274.7(t)0(h)13.2(e)]TJ 0 -1.0528 TD 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[(de)15.1(te)18.4(ri)17.3(or)19.6(at)18.4(io)13.2(n)-154.4(s)0(h)14.4(o)0(w)17.3(n)-154.4(in)-151.9(54)21.2(%)-162.5(o)0(f)-145.4(P)0(E)17.9(F)-159.3(re)19.2(co)15.1(rd)19.6(s)-161.3(\()0(p)19.6(r)0(o)19.6(b)0(a)15.1(b)0(l)18.9(y)-160.1(du)21.2(e)-160.5(t)0(o)]TJ 0 -1.0527 TD [(la)18.4(ck)-144.2(of)-139.7(ef)24.9(fo)19.6(rt)17.3(\),)-139.3(wh)11.6(i)13.9(c)0(h)-144.2(w)0(a)16.9(s)-149.9(ch)15.1(ar)19.2(ac)14.7(te)18.4(ri)17.3(ze)20.4(d)-154.4(b)0(y)-138.1(a)0(n)-144.2(i)0(m)15.7(m)0(e)17.7(d)0(i)18.9(a)0(t)18.5(e)-154.8(fa)19.2(ll)]TJ T* [(in)-151.9(P)11.4(E)0(F)-152.8(o)0(v)21.2(e)0(r)-151.5(t)0(h)13.2(e)-154.8(fi)11.6(rs)18.4(t)-156.8(f)0(e)13.5(w)-158.3(da)15.1(ys)-150.7(re)19.2(ac)20.4(hi)13.2(ng)-149.5(a)-160.5(p)0(l)18.9(a)0(t)18.5(e)0(a)14.7(u)-154.4(as)-151.1(sh)14.4(ow)17.3(n)-160.1(i)0(n)]TJ 0 -1.0471 TD [(fi)17.3(gu)15.5(re)-310.8(1,)-325.5(wi)-7.8(th)-334(no)-331.6(recover)-9.7(y)61.8(.)]TJ 1.0015 -1.0527 TD [(It)-221.7(co)15.1(ul)18.9(d)-234.1(b)0(e)-223.9(s)0(u)20(g)0(g)15.5(e)0(s)19.6(t)0(e)18.4(d)-234.1(th)18.9(at)-220.6(so)14.4(me)-221.3(of)-225.1(th)18.9(e)-234.5(d)0(e)20.8(t)0(e)12.8(r)0(i)17.3(o)0(r)19.6(a)0(t)18.4(i)0(o)18.9(n)-234.1(se)19.6(en)]TJ -1.0015 -1.0471 TD [(be)15.1(tw)20.6(ee)14.7(n)-416.2(t)0(h)18.9(e)-416.6(fi)17.3(rs)18.4(t)-412.9(t)0(w)14.9(o)-416.2(vi)18.9(si)17.7(ts)-403.4(is)-409.1(du)21.2(e)-416.6(t)0(o)-407.9(t)0(h)18.9(e)-416.6(re)19.2(qu)15.5(es)19.6(t)-418.6(f)0(o)19.6(r)-417.8(2-)]TJ 0 -1.0527 TD [(ho)15.5(ur)19.6(ly)-265.7(PE)17.9(F)-278.8(r)0(e)19.2(a)0(d)15.1(i)0(n)18.9(g)0(s)14.4(,)-273.5(as)-270.6(i)13.9(s)-280.8(us)20(ed)-269.4(in)-265.7(th)18.9(e)-280(i)0(n)18.9(v)0(e)15.1(s)0(t)17.7(i)0(g)18.9(a)0(t)18.4(i)0(o)18.8(n)-279.6(of)-264.9(oc)15.1(-)]TJ 0 -1.0471 TD [(cu)15.1(pa)20.8(ti)16.5(on)15.5(al)-192.1(as)13.9(th)18.8(ma)17.7(,)-205.2(r)0(a)13.5(t)0(h)18.9(e)0(r)-197(t)0(h)18.9(a)0(n)-195.4(2)0(\261)15.5(4)-205.6(re)19.2(ad)15.1(in)18.9(gs)20(,)-205.2(a)0(s)-196.6(i)0(s)-198.6(r)0(e)13.5(q)0(u)21.2(e)0(s)19.6(t)0(e)12.8(d)]TJ 0 -1.0527 TD [(fo)19.6(r)-565.7(t)0(h)13.2(e)-564.5(no)21.2(rm)16.5(al)-556.3(ma)12(na)20.8(ge)15.1(me)17.7(nt)-555.9(of)-555.1(as)19.6(th)13.2(ma)17.7(.)-563.7(H)0(o)17.3(w)0(e)16.9(v)0(e)15.1(r)43.2(,)-563.7(t)0(h)13.2(e)]TJ 0 -1.0471 TD [(au)15.1(th)18.9(or)19.6(s)-332(d)0(o)-325.9(n)0(o)21.2(t)-333.2(fe)13.5(el)-323(th)18.9(at)-323(th)13.2(i)13.9(s)-337.7(i)13.9(s)-337.7(th)18.9(e)-331.2(c)0(a)14.7(s)0(e)-321.8(a)0(s)-321.8(t)0(h)13.2(e)0(y)-320.6(h)0(a)15.1(v)0(e)-320.6(a)0(l)18.4(s)0(o)]TJ 0 -1.0528 TD [(re)19.2(co)15.1(rd)19.6(ed)-246.6(si)17.7(gn)15.5(if)17.3(ic)18.4(an)20.8(t)-253.5(l)0(e)12.8(a)0(r)19.2(n)0(i)18.9(n)0(g)-246.2(e)0(f)30.6(f)0(e)13.5(c)0(t)18.4(s)-252.3([1)13.9(2],)-253.9(with)-267.8(an)-263.7(incre)-8.6(ase)]TJ 0 -1.0471 TD [(in)-237.2(PEF)-238.2(over)-238.4(the)-238.4(record)-8.6(,)-239.4(i)0(n)-237.2(patients)-242.9(under)-239.1(the)-238.4(inves)-7.8(tigatio)-9.6(n)]TJ 0 -1.0528 TD [(of)-515.3(occupat)-8.9(ional)-515.4(asthma)-518.6(and)-514.8(performi)-11.1(ng)-513.7(2-hourly)-518.1(PEF)]TJ 0 -1.0471 TD [(readi)-8.6(ngs.)]TJ 1.0015 -1.0527 TD [(Th)17.1(e)-365.4(i)0(n)18.9(c)0(o)15.1(n)0(s)20(i)0(s)17.7(t)0(e)12.8(n)0(t)-356.7(d)0(e)20.8(t)0(e)18.4(r)0(i)11.6(o)0(r)19.6(a)0(t)18.5(i)0(o)18.9(n)-370.7(se)19.6(en)-354.7(in)-362.4(be)20.8(tw)14.9(ee)20.4(n)-370.7(4)0(6)-354.3(a)0(n)15.1(d)]TJ -1.0015 -1.0471 TD [(61)15.5(%)-441.3(o)0(f)-435.6(t)0(h)18.9(e)-445(se)19.6(ri)17.3(al)-436.8(P)11.4(E)0(F)-437.3(m)0(e)17.7(a)0(s)19.6(u)0(r)14(e)0(m)17.7(e)0(n)20.8(t)0(s)-437.6(m)0(a)17.7(y)-444.6(be)-434.4(du)21.2(e)-445(t)0(o)-436.4(a)]TJ 0 -1.0528 TD [(pa)15.1(ti)22.2(en)15.1(t)-225.1(w)0(h)17.3(o)0(s)14.4(e)-223.1(ef)24.9(fo)19.6(rt)-221.7(is)-215.6(in)18.9(co)15.1(ns)20(is)17.7(te)18.4(nt)13.2(;)-225.1(t)0(h)18.9(i)0(s)-215.7(m)0(a)12(y)-222.7(be)-218.2(in)18.9(te)12.8(rp)19.6(re)19.2(te)12.8(d)]TJ 0 -1.0471 TD [(as)-276.3(a)-280(f)0(a)19.2(l)0(s)17.7(e)0(l)12.8(y)-279.6(hi)18.9(gh)-274.7(di)18.9(ur)13.9(na)20.8(l)-282(v)0(a)15.1(r)0(i)17.3(a)0(t)18.4(i)0(o)18.9(n)-285.3(su)20(gg)15.5(es)19.6(ti)16.5(ng)-274.7(un)21.2(co)15.1(nt)18.9(ro)13.9(l)13.9(l)0(e)12.8(d)]TJ 0 -1.0527 TD [(as)19.6(th)13.2(ma)17.7(.)-711.7(T)12.2(he)15.1(se)-703.1(fa)19.2(ct)18.4(or)13.9(s)-707.6(n)0(e)15.1(e)0(d)-701.9(t)0(o)-703.8(b)0(e)-701.9(c)0(o)20.8(n)0(s)14.4(i)13.9(de)15.1(re)19.2(d)-712.1(w)0(h)17.3(e)0(n)]TJ 0 -1.0471 TD [(in)18.9(te)18.4(rp)13.9(re)19.2(ti)16.5(ng)-325.9(th)18.9(es)13.9(e)-336.9(P)11.4(EF)-329.2(re)19.2(co)15.1(rd)19.6(s)-337.7(a)0(n)15.1(d)-330.8(re)13.5(fe)19.2(re)13.5(nc)20.8(e)-336.9(m)0(a)17.7(d)0(e)-332(t)13.9(o)-336.5(t)0(h)13.2(e)]TJ 0 -1.0528 TD [(pa)15.1(ti)22.2(en)15.1(t)]TJ /F7 1 Tf 2.6233 0 TD (')Tj /F3 1 Tf 0.2106 0 TD [(s)-371.8(P)11.4(EF)-363.4(te)18.4(ch)15.1(ni)18.9(qu)15.5(e)-371.1(w)0(h)17.3(e)0(n)-366.1(t)13.9(he)15.1(y)-370.7(r)0(e)13.5(t)0(u)18.9(r)0(n)-361.6(b)0(e)15.1(f)0(o)19.6(r)0(e)-362(c)0(o)15.1(n)0(c)15.1(l)0(u)18.9(-)]TJ -2.8339 -1.0471 TD [(si)17.7(on)15.5(s)-212.5(a)0(r)19.2(e)-217.4(dr)19.6(aw)16.9(n)-217(f)0(r)18(o)0(m)-203.8(a)-217.4(P)11.4(E)0(F)-209.7(r)0(e)19.2(c)0(o)15.1(r)0(d)19.6(.)-210.9(In)-208(te)18.4(rm)16.5(s)-218.2(o)0(f)-202.3(a)0(n)-206.8(e)0(f)24.9(f)0(e)19.2(c)0(t)-203.5(o)0(n)]TJ 25.1977 64.0471 TD [(th)13.2(e)-388.1(d)0(i)18.9(a)0(g)15.1(n)0(o)21.2(s)0(i)17.7(s)-394.6(of)-378.7(oc)15.1(cu)20.8(pa)15.1(ti)16.5(on)21.2(al)-379.9(as)13.9(th)18.8(ma)17.7(,)-393(a)0(n)-377.5(i)0(m)15.7(p)0(o)15.5(r)0(t)17.3(a)0(n)20.8(t)-390.1(co)15.1(n-)]TJ 0 -1.0471 TD [(fo)13.9(un)21.2(di)13.2(ng)-360(ef)30.6(fe)13.5(ct)-362.8(sh)20(ou)15.5(ld)-362.4(on)21.2(ly)-362.4(be)-360.4(se)14(en)-360.4(if)-364(ef)30.6(fo)13.9(rt)-364(va)20.8(ri)17.3(es)-361.6(co)15.1(n-)]TJ 0 -1.0528 TD [(si)17.7(st)17.7(en)15.1(tl)16.5(y)-308.1(b)0(e)15.1(t)0(w)20.6(e)0(e)14.7(n)-308.1(da)15.1(ys)-298.6(at)-300.2(an)15.1(d)-308.1(a)0(w)16.9(a)0(y)-303.5(f)0(r)18(o)0(m)-300.6(w)0(o)17.3(r)0(k)14(.)-307.7(Th)17.1(is)-301(ma)17.7(y)]TJ 0 -1.0471 TD [(oc)15.1(cu)15.1(r)-201.5(i)0(f)-199(a)-206(pa)20.8(ti)16.5(en)15.1(t)-202.3(d)0(e)15.1(l)0(i)16.5(b)0(e)20.8(r)0(a)13.5(t)0(e)18.4(l)0(y)-197.4(t)0(r)17.3(i)0(e)18.4(s)-206.8(to)-197.4(fa)19.2(br)13.9(i)13.9(c)0(a)14.7(t)0(e)-197.8(a)-206(P)11.4(E)0(F)-198.3(r)0(e)19.2(c)0(o)15.1(r)0(d)]TJ 0 -1.0528 TD [(to)-316.9(su)14.4(gg)21.2(es)19.6(t)-327.5(o)0(c)20.8(c)0(u)15.1(p)0(a)15.1(t)13.9(io)13.2(na)20.8(l)-327.5(a)0(s)19.6(t)0(h)18.9(m)0(a)12(.)]TJ 1.0015 -1.0471 TD [(Af)15.7(te)12.8(r)-241.4(f)0(u)19.6(r)0(t)17.3(h)0(e)15.1(r)-241.4(re)19.2(tr)17.3(ai)12.8(ni)18.9(ng)-234.8(i)13.9(n)-245.5(P)11.4(E)0(F)-238.2(t)13.9(ec)14.7(hn)15.5(i)13.9(q)0(u)15.5(e)0(,)-234.9(d)0(u)21.2(r)0(i)17.3(n)0(g)-234.8(t)0(h)18.9(e)-245.9(en)20.8(-)]TJ -1.0015 -1.0528 TD [(co)15.1(ur)19.6(ag)15.1(ed)-383.2(PE)17.9(F)-398.3(m)0(e)17.7(a)0(s)19.6(u)0(r)14(e)0(m)17.7(e)0(n)15.1(t)-390.1(at)-385.6(vi)13.2(si)17.7(t)-390.1(2)0(,)-388.1(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)12.8(a)0(n)20.8(t)-395.8(di)18.9(f)14.7(f)0(e)19.2(r)20.4(-)]TJ 0 -1.0471 TD [(en)15.1(ce)14.7(s)-326.3(d)0(i)18.9(d)-330.8(no)15.5(t)-333.2(o)0(c)20.8(c)0(u)15.1(r)-326.7(be)15.1(tw)14.9(ee)20.4(n)-330.8(u)0(n)15.5(o)0(b)21.2(s)0(e)14(r)0(v)19.6(e)0(d)-320.6(a)0(n)15.1(d)-330.8(en)20.8(co)15.1(ur)19.6(ag)15.1(ed)]TJ 0 -1.0527 TD [(re)13.5(ad)20.8(in)13.2(gs)-332.8(at)-340.1(th)18.8(e)-342.6(t)0(h)13.2(i)13.9(rd)-338.9(vi)18.9(si)17.7(t)-344.6(s)0(u)14.4(g)0(g)21.2(e)0(s)13.9(t)0(i)16.5(n)0(g)-331.6(t)0(h)13.2(a)0(t)-334.4(g)0(o)15.5(o)0(d)-331.6(t)0(e)12.8(c)0(h)20.8(n)0(i)18.9(q)0(u)15.5(e)]TJ T* [(ha)15.1(d)-245.5(b)0(e)20.8(e)0(n)-235.2(p)0(r)13.9(e)0(s)19.6(e)0(r)13.5(v)0(e)20.8(d)-245.5(af)19.2(te)18.5(r)-247.1(t)0(h)18.8(e)-245.9(se)19.6(co)15.1(nd)-234.8(vi)18.9(si)17.7(t.)-236.8(Th)17.1(is)-238.4(w)12.4(a)0(s)-236.4(d)0(e)15.1(s)0(p)20(i)0(t)16.5(e)]TJ 0 -1.0471 TD [(a)-473.5(g)0(e)15.1(n)0(e)15.1(r)0(a)19.2(l)0(l)16.5(y)-473.1(po)21.2(or)13.9(er)-464.5(pe)20.8(rf)12.4(or)19.6(ma)17.7(nc)15.1(e)-473.5(o)0(f)-464.1(t)0(h)18.9(e)-473.5(su)14.4(bg)21.2(ro)13.9(up)-462.5(at)-465.2(th)18.9(e)]TJ 0 -1.0528 TD [(se)13.9(co)20.8(nd)-314.5(vi)13.2(si)17.7(t)-321.8(c)0(o)15.1(m)0(p)18.1(a)0(r)19.2(e)0(d)-314.9(t)0(o)-316.9(t)0(h)18.9(e)-325.5(gr)19.6(ou)15.5(p)-325.1(a)0(s)-316.1(a)-319.8(wh)11.6(ol)18.9(e.)]TJ 1.0015 -1.0471 TD [(Th)17.1(e)-342.6(f)0(a)19.2(c)0(t)-328.7(t)0(h)18.8(a)0(t)-334.4(s)0(o)20(m)0(e)-329.4(o)0(f)-333.2(t)0(h)18.9(e)-336.9(pa)15.1(ti)16.5(en)20.8(ts)-329.5(in)-328.3(th)13.2(e)-336.9(s)0(t)17.7(u)0(d)15.5(y)-336.5(al)18.5(re)19.2(ad)15.1(y)]TJ -1.0015 -1.0527 TD [(us)14.4(ed)-349.1(PE)17.9(F)-364.2(m)0(e)17.7(t)0(e)18.4(r)0(s)-357.1(p)0(r)19.6(i)0(o)18.9(r)-360.9(to)-356.7(th)18.9(e)-359.7(f)0(i)17.3(r)0(s)18.4(t)-361.6(vi)13.2(si)17.7(t)13.9(,)-364.6(an)20.8(d)-365(w)12.4(ho)15.5(se)-350.3(te)12.8(ch)20.8(-)]TJ 0 -1.0471 TD [(ni)13.2(qu)21.2(e)-314.2(d)0(e)20.8(t)0(e)18.4(r)0(i)11.6(o)0(r)19.6(a)0(t)18.4(e)0(d)-303.5(p)0(r)19.6(i)0(o)18.9(r)-315.3(to)-299.8(th)13.2(ei)18.4(r)-309.7(s)0(e)19.6(c)0(o)15.1(n)0(d)-303.1(v)0(i)18.9(s)0(i)17.7(t)-310.4(su)14.4(gg)21.2(es)13.9(ts)-301(th)18.9(at)]TJ 0 -1.0527 TD [(th)13.2(e)-336.9(i)0(m)15.7(p)0(r)19.6(o)0(v)15.5(e)0(m)17.7(e)0(n)15.1(t)-333.2(se)13.9(en)-326.3(at)-334.4(th)18.9(e)-336.9(t)0(h)18.9(i)0(r)17.3(d)-342.2(vi)18.9(si)17.7(t)-338.9(m)0(a)17.7(y)-336.5(no)15.5(t)-338.9(b)0(e)-326.3(l)0(o)13.2(n)0(g)21.2(-)]TJ 0 -1.0471 TD [(te)12.8(rm)16.5(.)]TJ 1.0015 -1.0528 TD [(Th)17.1(es)14(e)-479.2(r)0(e)19.2(s)0(u)20(l)0(t)16.5(s)-480(su)20(gg)15.5(es)19.6(t)-481.2(t)0(h)18.8(a)0(t)-470.9(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-466(s)0(h)14.4(o)0(u)21.2(l)0(d)-470.5(h)0(a)15.1(v)0(e)-468.6(t)0(h)18.8(e)0(i)18.4(r)]TJ -1.0015 -1.0471 TD [(pe)15.1(ak)-229.6(ex)15.1(pi)18.9(ra)13.5(t)13.9(o)0(r)13.9(y)-239.8(fl)17.3(ow)-233.1(te)18.5(ch)15.1(ni)18.9(qu)15.5(e)-240.2(c)0(h)20.8(e)0(c)14.7(k)0(e)20.8(d)-245.5(at)-231.9(ea)20.4(ch)-235.2(cl)18.4(in)18.9(ic)-231.9(vi)18.9(si)17.7(t)]TJ 0 -1.0527 TD [(wi)14.9(th)-413.6(re)19.2(tr)17.3(ai)18.5(ni)13.2(ng)-411.3(as)-412.8(ne)20.8(ce)14.7(ss)18.8(ar)19.2(y)-421.9(i)0(f)-415.2(t)0(h)18.9(e)-422.3(te)18.4(ch)15.1(ni)18.9(qu)21.2(e)-422.3(h)0(a)15.1(s)-417.4(de)15.1(te)18.5(ri)17.3(-)]TJ 0 -1.0471 TD [(or)13.9(at)18.5(ed)15.1(.)-404.4(P)11.4(at)12.8(ie)18.4(nt)18.9(s)-406(w)0(h)11.6(o)-404.8(de)15.1(mo)18.1(ns)20(tr)17.3(at)18.5(e)-410.9(p)0(o)21.2(o)0(r)-401.5(t)0(e)18.4(c)0(h)15.1(n)0(i)18.9(q)0(u)15.5(e)-405.2(sh)14.3(ou)21.2(ld)]TJ 0 -1.0528 TD [(ha)15.1(ve)-337.7(th)18.9(ei)12.8(r)-349.5(s)0(e)19.6(r)0(i)17.3(a)0(l)-340.1(p)0(e)20.8(a)0(k)-343.4(e)0(x)20.8(p)0(i)18.9(r)0(a)13.5(t)0(o)18.9(r)0(y)-338.9(f)0(l)17.3(o)0(w)-341.2(r)0(e)19.2(c)0(o)15.1(r)0(d)19.6(s)-349.1(co)15.1(ns)20(id)18.9(er)13.5(ed)]TJ 0 -1.0471 TD [(ca)14.7(re)19.2(fu)13.9(ll)16.5(y)-273.9(f)0(o)19.6(r)-275.5(ef)24.9(fe)19.2(ct)12.8(s)-275.1(w)12.4(hi)13.2(ch)-263.7(ma)17.7(y)-279.6(b)0(e)-263.7(d)0(u)15.5(e)-274.3(to)-271.4(t)13.9(e)0(c)14.7(h)0(n)15.5(i)13.9(qu)15.5(e)-274.3(r)0(a)13.5(t)0(h)18.8(e)0(r)]TJ 0 -1.0527 TD [(th)13.2(an)-314.9(tr)17.3(ue)-314.9(ai)18.5(rw)15.7(ay)-314.9(ch)15.1(an)20.8(ge)15.1(s.)]TJ /F5 1 Tf 8.966 0 0 8.966 402.349 512.617 Tm [(Refer)11.6(ences)]TJ /F3 1 Tf -10.3759 -2.2763 TD [(1.)-1766.5(May)-587(K,)-587.4(Janic)-588.6(G.)-587.4(Effect)-579.7(of)-588(patient)-591.2(co-operation)-594.2(and)]TJ 2.5165 -1.1128 TD [(muscular)-501.4(physique)-498.8(on)-498.5(maximum)-503.7(expiratory)-500.7(flow)-497.8(rate.)]TJ /F4 1 Tf 0 -1.1065 TD [(Pneumonologia)-333.5(Polska)]TJ /F3 1 Tf 9.6614 0 TD [(1985;)-334.9(53:)-336(53\26156.)]TJ -12.1779 -1.1128 TD [(2.)-1766.5(Allen)-258.2(JL,)-259.5(Castile)-268.3(RG,)-256.5(Mead)-263.8(J.)-256.5(Positive)-261.9(effort)-254.9(dependence)]TJ 2.5165 -1.1128 TD [(of)-385.7(maximum)-389.9(expiratory)-393.2(flow)64.9(.)]TJ /F4 1 Tf 12.4498 0 TD [(J)-391.3(Appl)-383.2(Physiol)]TJ /F3 1 Tf 6.443 0 TD [(1987;)-385.5(62:)]TJ -18.8929 -1.1128 TD (718\261724.)Tj -2.5165 -1.1065 TD [(3.)-1766.5(Connolly)-252(CK.)-250.2(Falsely)-253.4(high)-247(peak)-256.8(expiratory)-254.1(flow)-251.2(readings)]TJ 2.5165 -1.1128 TD [(due)-333.4(to)-330.2(acceleration)-342.1(in)-330.2(the)-335.8(mouth.)]TJ /F4 1 Tf 13.7334 0 TD (BMJ)Tj /F3 1 Tf 2.2004 0 TD [(1987;)-328.6(294:)-335.5(285.)]TJ -18.4503 -1.1128 TD [(4.)-1766.5(Colin)-234.6(A,)-233.3(Said)-232.7(E.)-233.5(How)-232.7(to)-235.3(cheat)-233.1(the)-234.6(Mini-W)29(right)-230.8(peak)-231.5(flow)]TJ 2.5165 -1.1128 TD [(meter)-337.3(\(letter\).)]TJ /F4 1 Tf 5.8108 0 TD (Chest)Tj /F3 1 Tf 2.5924 0 TD [(1984;)-334.9(86:)-329.7(156.)]TJ -10.9197 -1.1065 TD [(5.)-1766.5(Hetzel)-345.8(MR,)-348.7(W)32.8(illiams)-350.2(IP)102.6(,)-344.4(Shakespeare)-348.1(RM.)-348.7(Can)-344.4(patients)]TJ 2.5165 -1.1128 TD [(keep)-275.7(their)-281.2(own)-280(peak)-282(flow)-276.5(reliably?)]TJ /F4 1 Tf 14.1949 0 TD (Lancet)Tj /F3 1 Tf 2.9781 0 TD [(1979;)-556.3(i:)-282(597\261)]TJ -17.173 -1.1128 TD (599.)Tj -2.5165 -1.1128 TD [(6.)-1766.5(T)28.6(royanov)-288(S,)-285.5(Ghezzo)-290.4(H,)-290.2(Cartier)-291.9(A,)-283.9(Malo)-291.7(JL.)-284.8(Comparison)]TJ 2.5165 -1.1065 TD [(of)-385.7(circadian)-385.9(variations)-389.5(using)-380.4(FEV)]TJ 7.173 0 0 7.173 456.491 352.743 Tm (1)Tj 8.966 0 0 8.966 463.521 352.743 Tm [(and)-384(peak)-383.2(expiratory)]TJ -14.6818 -1.1128 TD [(flow)-301.8(rates)-305(among)-302.6(normal)-305.4(and)-301.8(asthmatic)-308.4(subjects.)]TJ /F4 1 Tf 19.9425 0 TD (Thorax)Tj /F3 1 Tf -19.9425 -1.1128 TD [(1994;)-334.9(49:)-329.6(775\261780.)]TJ -2.5165 -1.1065 TD [(7.)-1766.5(American)-591.8(Thoracic)-583.8(Society)57.6(.)-584.6(Standardization)-588.5(of)-588(spiro-)]TJ 2.5165 -1.1128 TD [(metry-1987)-253.8(update.)]TJ /F4 1 Tf 8.0175 0 TD [(Am)-252.4(Rev)-248.1(Respir)-257.9(Dis)]TJ /F3 1 Tf 7.7645 0 TD [(1987;)-246.4(136:)-253.3(1285\261)]TJ -15.782 -1.1128 TD (1307.)Tj -2.5165 -1.1128 TD [(8.)-1766.5(Chowienczyk)-250.7(PJ,)-248.3(Parkin)-245.2(DH,)-248.7(Lawson)-251.3(CP)105.2(,)-249.5(Cochrane)-247.5(GM.)]TJ 2.5165 -1.1065 TD [(Do)-375.3(asthmatic)-378(patients)-376.9(correctly)-374.5(record)-377.8(home)-372.7(spirometry)]TJ 0 -1.1128 TD (measurements.)Tj /F4 1 Tf 6.2407 0 TD (BMJ)Tj /F3 1 Tf 2.194 0 TD [(1994;)-334.9(309:)-329.1(1618.)]TJ -10.9513 -1.1128 TD [(9.)-1766.5(Quirce)-237.1(S,)-241.3(Contreas)-238.7(G,)-239.6(Dybuncio)-235.3(A,)-239.6(Chan-Y)95.5(eung)-238(M.)-237(Peak)]TJ 2.5165 -1.1128 TD [(expiratory)-393.2(flow)-390.3(monitoring)-390.6(is)-388.3(not)-386.6(a)-391.3(reliable)-389.1(method)-393(for)]TJ 0 -1.1065 TD [(establishing)-353.1(the)-348.4(diagnosis)-350.1(of)-347.7(occupational)-354.2(asthma.)]TJ /F4 1 Tf 20.7139 0 TD [(Am)-347.2(J)]TJ -20.7139 -1.1128 TD [(Respir)-333.8(Crit)-337.4(Car)33.6(e)-334.4(Med)]TJ /F3 1 Tf 9.2251 0 TD [(1995;)-334.9(152:)-335.5(1)32.1(100\2611)34.2(102.)]TJ -11.7416 -1.1128 TD [(10.)-1266.5(Siracusa)-333.5(A,)-328.2(Forcina)-326.7(A,)-328.2(Brugnami)-334.4(G,)-328.2(Ranciaro)-332.1(A,)-328.2(Fiordi)]TJ 2.5165 -1.1065 TD [(T)72.9(,)-312.7(Marabini)-318(A.)-309.2(Monitoring)-313.5(of)-316.1(peak)-313.7(expiratory)-317.3(flow)-314.5(rates)]TJ 0 -1.1128 TD [(during)-689.5(occupational)-695.6(asthma)-691.1(treatment.)]TJ /F4 1 Tf 17.1794 0 TD [(Medicina)-696.2(del)]TJ -17.1794 -1.1128 TD 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