抽象的
在欧洲社区呼吸系统疗效研究(ECRH)中,使用Mefar剂量表协议测定气道对甲素的反应性。在其他地方,2分钟的潮气呼吸方法已成为首选的标准化方法。这两种方法对响应性测量之间的关系不是很好的。本研究通过剂量计和潮气呼吸方法测量气道对甲素的反应性,在47岁20-44岁的健康哮喘受试者中测量剂量和潮气呼吸方法。测试在1周内和随机顺序内进行。基线强制呼气量在一秒(FEV1)在42/47个受试者中的测试之间变化<10%。通过两种方法确定的响应性之间存在密切关联。甲素的促进浓度导致20%的FEV1(PC20)值<或= 8.0mg x ml(-1)(潮汐法),用于对气道高反应性的含量最密切地与促进剂量的甲素进行分类,导致20%落入fev1(pd20)值<或= 0.5 mg(剂量计法)(Kappa统计0.78)。每个PC20的每倍或减半,以定义与PD20的加倍或减半密切合法的高光反应性。 Assessment of airway responsiveness as provocative dose of methacholine causing a 20% fall in forced expiratory volume in one second by the Mefar dosimeter protocol gave a close and predictable relationship with provocative concentration of methacholine causing a 20% fall in expiratory volume in one second assessed using the tidal breathing method. Airway hyperresponsiveness as determined by the accepted criterion of provocative concentration of methacholine causing a 20% fall in expiratory volume in one second < or =8 mg x mL(-1) was best correlated with provocative dose of methacholine causing a 20% fall in forced expiratory volume in one second <0.5 mg by Mefar dosimeter.