抽象的
在一次随访的早期和之后,已经在提前和之后进行了无侵入的慢性阻塞性肺病(COPD)中的非侵入性正压机械通气(NIPPV)。为此,30名患者注册了预期,对照试验:15患儿早期施用NIPPV(A组),仅有15例医疗治疗(B组);根据设备可用性进行任务。在医院的死亡率,需要对A组中的气管内插管和平均住院时间的平均长度较低,但差异没有统计学意义。动脉血(PA,O 2)中的动脉氧气张力,动脉血(PA,CO2)和HCO3中的二氧化碳张力在两组中显着改善,从入院排放到排放:45.8 +/- 8.6与64.9 +/- 10.0;59.4 +/- 11.8与48.6 +/- 7.3;34.3 +/- 4.3与A组中的30.1 +/- 3.4;49.2 +/- 11.4与60.9 +/- 8.2;52.6 +/- 15.9与44.4 +/- 8.7;31.7 +/- 5.9与B组的28.0 +/- 3.6分别,P <0.05对于所有比较; pH, percentage forced expiratory volume in one second (FEV1) and tidal volume (VT) improved significantly in patients of group A only: 7.36+/-0.04 versus 7.41+/-0.02; 39.8+/-13.6 versus 49.4+/-11.7; 0.71+/-0.3 versus 0.84+/-0.4, respectively, p<0.05. During follow-up, 3, 6, and 12 months survival rates were significantly higher in Group A than in Group B (p<0.02). Hospital new admissions over 1 yr were more frequent in Group B (n=6, incidence rate: 0.216%) than in Group A (n=4, incidence rate: 0.084%). Therefore, noninvasive positive pressure mechanical ventilation may be added to "conventional" medical therapy in exacerbated chronic obstructive pulmonary disease.