抽象
嗜中性粒细胞募集到气道慢性阻塞性肺疾病(COPD)被认为介导的组织破坏。在细菌加重中性粒细胞募集增加。炎症过程是在COPD患者的急性加重研究,以确定白三烯B4(LTB4)的作用。的8名受试者患有COPD的恶化细菌痰分析嗜中性粒细胞制品(髓过氧化物酶,弹性蛋白酶)和化学引诱物(白介素-8(IL-8)和LTB4)。使用LTB4受体拮抗剂LY293111测定LTB4的到痰溶胶相的趋化活性的贡献。测定血清急性期蛋白α1 - 蛋白酶抑制剂,α1 - 抗胰凝乳蛋白酶和C-反应蛋白的浓度。接受了适当的广谱抗生素治疗7-14天所有患者。最初,痰髓过氧化物酶活性是高的,表明嗜中性粒细胞流入;这是与高水平的IL-8和LTB4的相关联。所有这些浓度降至与治疗(P <0.01)。 The chemotactic activity of the sputum was raised on presentation and fell with treatment (p<0.01). LTB4 contributed approximately 30% of the total chemotactic activity on presentation; this diminished with therapy. All acute phase proteins were raised on presentation and fell with therapy (p<0.01). These findings suggest that leukotriene B4 contributes to neutrophil influx into the airway in chronic obstructive pulmonary disease and may influence disease progression.