抽象的
EBSELEN(2-苯基-1,2-苯并异质酶-3(2H) - 酮)是苯乙烯 - 有机化合物,可保护组织免受氧化应激。此外,最近的数据表明该化合物具有一系列抗炎性能。在这项研究中,作者研究了EBSELEN对大鼠血管诱导的肺水肿和支气管瘤性坏死因子(TNF)肿瘤坏死因子(TNF) - 大鼠内皮(ET)-1水平的影响。Sephadex施用诱导肺水肿,伴随着BAL TNF-α和ET-1水平的增加。Ebselen administration (1-30 mg x kg(-1), i.p. at 0, 4 and 12 h post Sephadex) significantly inhibited lung oedema (dose that produced 50% of the maximum inhibition of lung oedema 4.6 mg x kg(-1)) and BAL TNF-alpha levels in a dose-related manner with no effect on ET-1 levels. These data suggest that ebselen may be a useful therapy in lung pathologies in which bronchiolar inflammation is a feature.