抽象的
我们希望确定高渗盐水(HS)挑战后的耐火剂是否是由于桅杆细胞介质枯竭。因此,在吸入HS气溶胶之后测定通过肥大细胞组胺释放的腺苷5'-单磷酸胺(AMP)对腺苷5'-单磷酸(AMP)的气道反应性。九次哮喘科目三次参加了实验室。在第1天,通过第二个HS挑战,在一小时后进行挑战。在第2天,进行了AMP挑战。在第3天,通过AMP挑战后一小时进行HS挑战。气道响应性(PD35 SGAW)到初始HS挑战的攻击范围为12至315升气溶胶(平均47 L)。Airway对第二个HS挑战的反应性范围从8到800 L(平均102L p = 0.035,n = 9)。气道对AMP的反应性从0.44至14.0 mumol(平均2.37 mumol)增加到0.3至15.5(平均1.3 mumol)(平均1.3 mumol)(p = 0.05)。基线AMP响应性与基线HS响应性之间存在线性相关性(r = 0.911,p = 0.001)。 There was no correlation between the degree of refractoriness and the change in AMP responsiveness (r = 0.1, p = 0.9). Thus airway responsiveness to AMP increased significantly after inhalation of HS aerosol and this increase was independent of refractory behaviour. Our results suggest that the refractory period to HS is not due to mediator depletion.