给编辑:
关于临床u存在相当大的混乱se of exhaled nitric oxide measurement in general, and its bronchial and alveolar contributions in particular, for instance in response to treatment. An additional effect needs to be factored in when considering the degree of alveolar nitric oxide abnormality and its response to therapeutic interventions that may or may not be targeted to the lung periphery. Indeed, the alveolar nitric oxide value computed from exhaled nitric oxide measurement at multiple flows with the so-called slope-intercept method [1,,,,2]可以高估肺泡空气空间中炎症产生的真正一氧化氮。当支气管一氧化氮后膨胀到肺泡空气空间时,就会产生这种高估,从而污染肺泡一氧化氮的测量,其一氧化氮源自较高的气道。已经独立发布了两个更正公式[3,,,,4] proposing to estimate true alveolar nitric oxide by subtracting from the measured alveolar nitric oxide a bronchial nitric oxide-dependent portion corresponding to back-diffusion. However, it has also been shown that airway constriction of peripheral conductive airways may at least partly impair back-diffusion [5]。因此,在外周肺疾病的情况下,假设未损坏的背扩散的校正公式的应用可能会错误地导致过度纠正,并最终导致负肺泡一氧化氮值。真正的肺部问题在于,尽管可以设想一些小型气道收缩的独立措施来确定这一点,但很难判断是否及其在何种程度上受到了损害。同时,我们在这里提倡一种更务实的方法。
检查未校正的牙槽一氧化氮浓度的一种方法(CA,不)对于真正的异常是首先绘制它…