文摘
随访的254例胸内结节病进行了平均27岁的诊断后入学。所有的病人可以追踪。随访结束时没有超额死亡率预计观察和65.5(80人死亡)。然而,在前20年的随访中稍微超额死亡率。30 80人死亡的三个与结节病有关。没有多余的死亡人数肺癌或淋巴瘤被观察到。结节性红斑是关于生存的预后意义。x射线阶段有关生存显著超额死亡率的第三阶段。x射线的变化的早期清除了有利预后至关重要。生存与肺功能,在一秒用力呼气量(FEV1)、FEV1 /用力肺活量(FVC)指数和肺活量(TLC)这种关系达到统计显著性水平。 In multivariate Cox regression models, with age and sex entered as covariates, the same parameters were found to be significant predictors of mortality. Patients with FEV1 < or = 50% predicted had an increased mortality risk of 4.2 (95% confidence interval 1.8-9.6) when compared to patients with FEV1 > 80% predicted. Likewise, patients with TLC < or = 80% predicted had a mortality risk of 2.6 (1.5-4.5) when compared to patients with TLC > 80% predicted. In conclusion, a modest excess mortality was observed during the first 20 yrs of follow-up. Furthermore, both X-ray staging and lung function at the time of diagnosis influenced long-term mortality in patients with intrathoracic sarcoidosis.