抽象的
高氧是广泛用作急性肺损伤的模型。药物戊氧化碱已被证明在其他肺损伤模型中具有保护作用。我们试图通过减少肺内的中性粒细胞的积累来确定戊氧基可均可碱是否可以防止大鼠的高氧肺损伤。研究了84只大鼠。二十四只大鼠随机分为四组。用五氧化石(20mg.kg-1)或盐水预处理了两组大鼠48小时,然后在治疗持续处理时暴露于> 95%O 2 60小时。两组对照大鼠接受了相同的治疗方案作为O2暴露的动物,但呼吸室空气。通过组织学和髓过氧化物酶活性来量化肺中的嗜嗜中性粒细胞积累。与接受盐水注射的氧气或空气暴露的大鼠相比,肺中性粒细胞累积在接受氧杂化基团的氧暴露基团中增加。从超氧化,戊氧化碱处理基团的肺匀浆总谷胱甘肽含量高于来自其他三组的匀浆。 To study survival, 60 rats were exposed to > 95% O2 for 120 h, 30 rats were pretreated with pentoxifylline, and 30 received saline. Survival after 120 h of exposure to hyperoxia was not altered by pentoxifylline treatment (pentoxifylline treated: 6 out of 30 survived; saline treated: 2 out of 30 survived). We conclude that pentoxifylline does not reduce mortality or lung injury in rats exposed to hyperoxia and is associated with an increase in lung neutrophil accumulation.