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0.0038 Tc 9 0 0 9 242.837 693.856 Tm (Predicted )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0138 Tc 9.3 0 0 9.3 193.88 674.65 Tm (4.07\2610.69 )Tj EMC /Suspect <>BDC 0 Tc 5.161 0 Td (4)Tj 0.337 0.337 0.329 rg -0.0192 Tc (.02\2610.5)Tj 0.161 0.161 0.153 rg 0 Tc 3.48 0 Td (1 )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0133 Tc 9.3 0 0 9.3 193.8707 666.9682 Tm (2.49\2611.23 )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 0 Tc 9.3 0 0 9.3 241.8122 666.9682 Tm (3)Tj 0.161 0.161 0.153 rg -0.0141 Tc 0.508 0 Td (.66\2610.40 )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0021 Tc 9 0 0 9 47.48 651.12 Tm (FEV)Tj 0 Tc 7 0 0 7 65.04 647.76 Tm (1)Tj 0.42 0.48 Td (: )Tj -0.0129 Tc 9 0 0 9 75.26 651.12 Tm (forced )Tj 0.0023 Tc 3.04 0 Td (expiratory )Tj 0.0097 Tc 4.596 0 Td (volume )Tj -0.035 Tc 9.2582 0 0 9.4 176.08 651.12 Tm (in )Tj 0.0354 Tc 9 0 0 9 187.11 651.12 Tm (one )Tj 0.0022 Tc 1.916 0 Td (second; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0249 Tc 7 0 0 7 236.13 651.12 Tm (BTPS: )Tj EMC ET BT /T1_0 1 Tf -0.0057 Tc 9 0 0 9 260.65 651.12 Tm (body )Tj 0.161 0.161 0.153 rg -0.0003 Tc -23.683 -0.853 Td (temperature, )Tj 0.243 0.247 0.235 rg 0.0132 Tc 5.71 0 Td (pressure )Tj -0.0015 Tc 4.093 0 Td (\(atmospheric\), )Tj -0.0226 Tc 6.562 0 Td (and )Tj 0.0037 Tc 2.129 0 Td (saturation )Tj 0.0056 Tc 4.642 0 Td (\(water )Tj 0.161 0.161 0.153 rg 0.0009 Tc -23.19 -0.906 Td (vapour\). )Tj 0.243 0.247 0.235 rg /T1_3 1 Tf -0.0255 Tc 10.7 0 0 10.7 47.12 608.89 Tm (Experimental )Tj -0.035 Tc 10.5776 0 0 10.7 105.54 608.89 Tm (design )Tj /T1_0 1 Tf -0.0283 Tc 10.6 0 0 10.6 56.59 586.8 Tm (Basel)Tj 0.078 0.078 0.071 rg -0.035 Tc 10.5807 0 0 10.6 78.63 586.8 Tm (in)Tj 0.243 0.247 0.235 rg 0 Tc 10.6 0 0 10.6 86.29 586.8 Tm (e )Tj 0.161 0.161 0.153 rg -0.025 Tc 0.827 0 Td (pulmonary )Tj 0.243 0.247 0.235 rg 0 Tc 4.56 0 Td (f)Tj 0.078 0.078 0.071 rg -0.035 Tc 9.9544 0 0 10.6 146.88 586.8 Tm (un)Tj 0.243 0.247 0.235 rg -0.0301 Tc 10.6 0 0 10.6 156.38 586.8 Tm (ction )Tj -0.035 Tc 10.0572 0 0 10.6 180.95 586.8 Tm (was )Tj -0.0292 Tc 10.6 0 0 10.6 200.53 586.8 Tm (assessed )Tj 0.161 0.161 0.153 rg -0.035 Tc 10.0482 0 0 10.6 239.05 586.8 Tm (by )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.2832 0 0 10.6 253.42 586.8 Tm (meas\255)Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0246 Tc 10.6 0 0 10.6 47.52 575.76 Tm (urement )Tj 0.0478 Tc 3.613 0 Td (of )Tj -0.0342 Tc 1.402 0 Td (forced )Tj -0.0213 Tc 2.944 0 Td (expiratory )Tj 0.161 0.161 0.153 rg -0.035 Tc 10.5664 0 0 10.6 179.5 575.76 Tm (volume )Tj 10.5807 0 0 10.6 214.95 575.76 Tm (in )Tj 0.243 0.247 0.235 rg -0.0321 Tc 10.6 0 0 10.6 228.86 575.76 Tm (one )Tj -0.035 Tc 10.4399 0 0 10.6 249.45 575.76 Tm (second )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 10.5289 0 0 10.6 47.4 564.73 Tm (\(FEV)Tj 0 Tc 6.2 0 0 6.2 69.87 561.36 Tm (1)Tj 0.415 0.544 Td (\) )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0319 Tc 10.6 0 0 10.6 79.2 564.73 Tm (using )Tj 0.337 0.337 0.329 rg 0 Tc 2.299 0 Td (a )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.2902 0 0 10.6 111.26 564.73 Tm (dry-bcUows )Tj 0.337 0.337 0.329 rg -0.0241 Tc 10.6 0 0 10.6 161.61 564.73 Tm (spirometer )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0301 Tc 10.6 0 0 10.6 207.2324 564.73 Tm (\(Vilalograph )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0284 Tc 10.6 0 0 10.6 260.5822 564.73 Tm (Ltd, )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_1 1 Tf 0.0363 Tc 9.9 0 0 9.9 47.29 554.17 Tm (UK\) )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.5732 0 0 10.6 69.97 554.17 Tm (and )Tj 0.0478 Tc 10.6 0 0 10.6 89.18 554.17 Tm (of )Tj -0.0195 Tc 1.263 0 Td (specific )Tj 0.243 0.247 0.235 rg -0.0252 Tc 3.4 0 Td (airway )Tj 0.337 0.337 0.329 rg -0.0263 Tc 3.035 0 Td (conductance )Tj -0.0322 Tc 5.159 0 Td (\(sGaw\) )Tj 0.161 0.161 0.153 rg -0.035 Tc 9.9195 0 0 10.6 260.08 554.17 Tm (in )Tj 0.243 0.247 0.235 rg 0 Tc 10.6 0 0 10.6 272.53 554.17 Tm (a )Tj 0.337 0.337 0.329 rg -0.0246 Tc -21.282 -1.042 Td (constant-volume )Tj 0.243 0.247 0.235 rg -0.0144 Tc 6.576 0 Td (body )Tj -0.0348 Tc 2.265 0 Td (plethysmograph )Tj 0.337 0.337 0.329 rg -0.035 Tc 10.588 0 0 10.6 208.19 543.12 Tm (\(Fenyves )Tj /T1_1 1 Tf 0 Tc 10.3 0 0 10.3 248.51 543.12 Tm (& )Tj 0.161 0.161 0.153 rg /T1_0 1 Tf -0.0346 Tc 10.6 0 0 10.6 259.57 543.12 Tm (Gut, )Tj -0.0183 Tc -20.055 -1.041 Td (Basel, )Tj -0.0206 Tc 2.749 0 Td (Switzerland\). )Tj 0.243 0.247 0.235 rg -0.0211 Tc 5.489 0 Td (The )Tj -0.0145 Tc 1.896 0 Td (subject )Tj -0.035 Tc 10.4177 0 0 10.6 187.65 532.09 Tm (then )Tj 10.3615 0 0 10.6 208.71 532.09 Tm (inhaJed )Tj 10.1679 0 0 10.6 242.3 532.09 Tm (an )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0348 Tc 10.6 0 0 10.6 256.21 532.09 Tm (aero\255)Tj EMC ET BT /T1_0 1 Tf -0.027 Tc 10.6 0 0 10.6 46.8918 521.0448 Tm (sol )Tj 0.0478 Tc 1.544 0 Td (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.55 0 0 10.6 76.69 521.05 Tm (0.9% )Tj EMC /Suspect <>BDC 0.161 0.161 0.153 rg 10.3043 0 0 10.6 102.77 521.05 Tm (NaCl )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0236 Tc 10.6 0 0 10.6 128.54 521.05 Tm (containing )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 7 0 0 7 175.6 523.92 Tm (9)Tj -0.035 Tc 9.9399 0 0 10.6 178.45 521.05 Tm (9m'fechnetium )Tj EMC /Suspect <>BDC 0 Tc 10.6 0 0 10.6 238.91 521.05 Tm (\()Tj 7 0 0 7 241.84 523.92 Tm (9)Tj -0.035 Tc 8.6305 0 0 10.6 245.18 521.05 Tm (9mTcO..\) )Tj EMC ET BT /T1_0 1 Tf -0.0219 Tc 10.6 0 0 10.6 46.94 510 Tm (delivered )Tj 0.161 0.161 0.153 rg -0.035 Tc 10.0797 0 0 10.6 90.61 510 Tm (from )Tj 0 Tc 10.6 0 0 10.6 115.09 510 Tm (a )Tj -0.0066 Tc 1.002 0 Td (Hudson's )Tj -0.0226 Tc 4.17 0 Td (nebulizer )Tj 0.243 0.247 0.235 rg -0.0281 Tc 4.022 0 Td (connected )Tj -0.035 Tc 10.3833 0 0 10.6 259.17 510 Tm (to )Tj 0 Tc 10.6 0 0 10.6 272.05 510 Tm (a )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf -0.0287 Tc 10.6 0 0 10.6 46.9378 499.4424 Tm (dosimete)Tj 0.161 0.161 0.153 rg 0 Tc 3.404 0 Td (r)Tj 0.337 0.337 0.329 rg 0.393 0 Td (, )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 10.2207 0 0 10.6 93.98 499.44 Tm (and )Tj 0.161 0.161 0.153 rg 10.1786 0 0 10.6 113.68 499.44 Tm (imm)Tj 0.337 0.337 0.329 rg -0.0345 Tc 10.6 0 0 10.6 131.89 499.44 Tm (edia)Tj 0.161 0.161 0.153 rg 0 Tc 1.592 0 Td (t)Tj 0.337 0.337 0.329 rg -0.0341 Tc 0.219 0 Td (ely )Tj -0.013 Tc 1.63 0 Td (after )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.4219 0 0 10.6 191.97 499.44 Tm (this )Tj 0 Tc 10.6 0 0 10.6 211.09 499.44 Tm (a )Tj -0.024 Tc 0.873 0 Td (posterior )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.5414 0 0 10.6 260.61 499.44 Tm (tho\255)Tj EMC ET BT 0.161 0.161 0.153 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 47.02 488.41 Tm (r)Tj 0.337 0.337 0.329 rg -0.0335 Tc 0.308 0 Td (acic )Tj -0.035 Tc 10.5062 0 0 10.6 71.37 488.41 Tm (scan )Tj 0.243 0.247 0.235 rg 10.3816 0 0 10.6 94.07 488.41 Tm (was )Tj -0.0263 Tc 10.6 0 0 10.6 114.26 488.41 Tm (performed. )Tj -0.0281 Tc 4.66 0 Td (Approximately )Tj 0.337 0.337 0.329 rg /T1_3 1 Tf 0 Tc 10.7 0 0 10.7 229.33 488.41 Tm (5 )Tj 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 9.7327 0 0 10.6 239.02 488.41 Tm (min )Tj 0.078 0.078 0.071 rg 0 Tc 10.6 0 0 10.6 259.11 488.41 Tm (l)Tj 0.243 0.247 0.235 rg -0.012 Tc 0.225 0 Td (ater )Tj 0.161 0.161 0.153 rg -0.035 Tc 9.7344 0 0 10.6 47.02 477.84 Tm (th)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 54.61 477.84 Tm (e )Tj -0.022 Tc 0.902 0 Td (subject )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.3816 0 0 10.6 97.91 477.84 Tm (was )Tj -0.0271 Tc 10.6 0 0 10.6 118.58 477.84 Tm (premedicated )Tj -0.035 Tc 10.3688 0 0 10.6 177.59 477.84 Tm (with )Tj 0.337 0.337 0.329 rg 10.2864 0 0 10.6 200.06 477.84 Tm (ae)Tj 0.161 0.161 0.153 rg 0 Tc 10.6 0 0 10.6 209.26 477.84 Tm (r)Tj 0.337 0.337 0.329 rg -0.0277 Tc 0.264 0 Td (oso)Tj 0.161 0.161 0.153 rg 0 Tc 1.359 0 Td (l)Tj 0.337 0.337 0.329 rg 0.221 0 Td (s )Tj 0.0478 Tc 0.82 0 Td (of )Tj 0 Tc 1.267 0 Td (e)Tj 0.161 0.161 0.153 rg -0.035 Tc 10.4149 0 0 10.6 255.75 477.84 Tm (ith)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 265.81 477.84 Tm (e)Tj 0.161 0.161 0.153 rg 0.461 0 Td (r)Tj 0.337 0.337 0.329 rg 0.339 0 Td (: )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.5214 0 0 10.6 46.45 466.81 Tm (a\) )Tj -0.029 Tc 10.6 0 0 10.6 58.41 466.81 Tm (salbutamo)Tj 0.078 0.078 0.071 rg 0 Tc 3.9 0 Td (l )Tj 0.243 0.247 0.235 rg -0.0191 Tc 0.583 0 Td (sulphate )Tj 0.161 0.161 0.153 rg 0 Tc 3.543 0 Td (t)Tj 0.337 0.337 0.329 rg 0.22 0 Td (o )Tj -0.0174 Tc 0.77 0 Td (cause )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.3581 0 0 10.6 180.49 466.81 Tm (br:onchodilatation )Tj 10.357 0 0 10.6 254.3 466.81 Tm (or; )Tj 9.7413 0 0 10.6 269.29 466.81 Tm (b\) )Tj -0.0235 Tc 10.6 0 0 10.6 47.02 456.25 Tm (methacholine )Tj -0.035 Tc 10.3833 0 0 10.6 105.57 456.25 Tm (to )Tj 0.337 0.337 0.329 rg -0.0174 Tc 10.6 0 0 10.6 117.5 456.25 Tm (cause )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.5954 0 0 10.6 144.49 456.25 Tm (bronchocon)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 191.37 456.25 Tm (s)Tj 0.243 0.247 0.235 rg -0.0349 Tc 0.419 0 Td (triction. )Tj -0.035 Tc 9.8048 0 0 10.6 231.29 456.25 Tm (In )Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 243.26 456.25 Tm (o)Tj 0.161 0.161 0.153 rg -0.035 Tc 10.2295 0 0 10.6 248.63 456.25 Tm (rd)Tj 0.337 0.337 0.329 rg 0.0136 Tc 10.6 0 0 10.6 256.69 456.25 Tm (er )Tj 0.243 0.247 0.235 rg -0.035 Tc 9.7344 0 0 10.6 269.26 456.25 Tm (to )Tj 0.337 0.337 0.329 rg -0.0099 Tc 10.6 0 0 10.6 46.05 445.21 Tm (tes)Tj 0.161 0.161 0.153 rg 0 Tc 1.177 0 Td (t )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 10.4562 0 0 10.6 64.77 445.21 Tm (the )Tj EMC /Suspect <>BDC -0.0262 Tc 10.6 0 0 10.6 80.62 445.21 Tm (reproducibility )Tj EMC ET BT /T1_0 1 Tf 0.0478 Tc 10.6 0 0 10.6 143.425 445.21 Tm (of )Tj -0.035 Tc 10.4562 0 0 10.6 155.97 445.21 Tm (the )Tj -0.0269 Tc 10.6 0 0 10.6 171.26 445.21 Tm (distribution )Tj 0.0478 Tc 4.664 0 Td (of )Tj -0.027 Tc 1.185 0 Td (radioactive )Tj 0.337 0.337 0.329 rg -0.0193 Tc -17.624 -1.042 Td (aerosol, )Tj -0.022 Tc 3.442 0 Td (another )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.5771 0 0 10.6 117.99 434.16 Tm (group )Tj 0.0478 Tc 10.6 0 0 10.6 145.82 434.16 Tm (of )Tj 0.337 0.337 0.329 rg -0.0227 Tc 1.218 0 Td (subjects )Tj 0.161 0.161 0.153 rg -0.035 Tc 10.0769 0 0 10.6 196.24 434.16 Tm (inh)Tj 0.337 0.337 0.329 rg 10.5499 0 0 10.6 208.69 434.16 Tm (aled )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0255 Tc 10.6 0 0 10.6 229.81 434.16 Tm (0.9)Tj 0.4 0.4 0.392 rg 0 Tc 1.223 0 Td (% )Tj EMC /Suspect <>BDC 0.243 0.247 0.235 rg -0.035 Tc 10.0241 0 0 10.6 255.4 434.16 Tm (NaCI )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 46.46 423.61 Tm (o)Tj 0.161 0.161 0.153 rg -0.035 Tc 10.4885 0 0 10.6 51.83 423.61 Tm (nly. )Tj 0.243 0.247 0.235 rg -0.0306 Tc 10.6 0 0 10.6 76.75 423.61 Tm (Measurements )Tj 0.0478 Tc 6.38 0 Td (of )Tj -0.0307 Tc 1.687 0 Td (pulmonary )Tj -0.035 Tc 10.5148 0 0 10.6 214.92 423.61 Tm (function )Tj 10.483 0 0 10.6 257.27 423.61 Tm (were )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 10.5589 0 0 10.6 47.02 412.56 Tm (repeated )Tj EMC /Suspect <>BDC 10.3438 0 0 10.6 84.36 412.56 Tm (30 )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf 9.7327 0 0 10.6 98.38 412.56 Tm (min )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0243 Tc 10.6 0 0 10.6 117.01 412.56 Tm (after )Tj EMC ET BT /T1_0 1 Tf -0.0296 Tc 10.6 0 0 10.6 138.74 412.56 Tm (premedication, )Tj -0.035 Tc 10.2207 0 0 10.6 201.5 412.56 Tm (and )Tj 0 Tc 10.6 0 0 10.6 219.25 412.56 Tm (a )Tj 0.337 0.337 0.329 rg -0.035 Tc 10.4399 0 0 10.6 227.85 412.56 Tm (second )Tj -0.0248 Tc 10.6 0 0 10.6 258.57 412.56 Tm (scan )Tj 0.0478 Tc -20.01 -1.041 Td (of )Tj 0.161 0.161 0.153 rg -0.035 Tc 9.0854 0 0 10.6 60.94 401.53 Tm (th)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 68.05 401.53 Tm (e )Tj 0.243 0.247 0.235 rg -0.0127 Tc 0.918 0 Td (posterior )Tj -0.035 Tc 10.5066 0 0 10.6 119.97 401.53 Tm (thorax )Tj 10.3816 0 0 10.6 151.19 401.53 Tm (was )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf -0.0292 Tc 10.6 0 0 10.6 172.22 401.53 Tm (obtained )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 9.7344 0 0 10.6 212.62 401.53 Tm (to )Tj 0.337 0.337 0.329 rg -0.0195 Tc 10.6 0 0 10.6 225.49 401.53 Tm (estimate )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.4562 0 0 10.6 264.45 401.53 Tm (the )Tj -0.0247 Tc 10.6 0 0 10.6 46.06 390.49 Tm (residual )Tj -0.035 Tc 10.5954 0 0 10.6 85.93 390.49 Tm (background )Tj 0.161 0.161 0.153 rg 10.2784 0 0 10.6 140.63 390.49 Tm (radi)Tj 0.337 0.337 0.329 rg -0.0213 Tc 10.6 0 0 10.6 155.9 390.49 Tm (oactivity. )Tj 0.243 0.247 0.235 rg -0.0211 Tc 4.212 0 Td (The )Tj 0.337 0.337 0.329 rg -0.0253 Tc 2.168 0 Td (subjec)Tj 0.161 0.161 0.153 rg 0 Tc 2.457 0 Td (t )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.12 0 0 10.6 259.66 390.49 Tm (then )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0345 Tc 10.6 0 0 10.6 46.95 379.93 Tm (inhaled )Tj EMC ET BT 0.161 0.161 0.153 rg /T1_0 1 Tf -0.035 Tc 9.0854 0 0 10.6 80.14 379.93 Tm (th)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 87.25 379.93 Tm (e )Tj -0.0114 Tc 0.766 0 Td (same )Tj 0.243 0.247 0.235 rg -0.0303 Tc 2.323 0 Td (number )Tj 0.0025 Tc 3.207 0 Td (of )Tj -0.035 Tc 10.5772 0 0 10.6 166.1 379.93 Tm (puffs )Tj 0.337 0.337 0.329 rg 0.0478 Tc 10.6 0 0 10.6 189.98 379.93 Tm (of )Tj ET BT /Suspect <>BDC 0.4 0.4 0.392 rg /T1_0 1 Tf 0 Tc 6.3001 0 0 6.3001 201.53 382.81 Tm (9)Tj -0.035 Tc 6.3101 0 0 10.6 204.89 379.93 Tm (9m)Tj 0.243 0.247 0.235 rg 0.05 Tc 10.8522 0 0 10.6 212.55 379.93 Tm (Tc0)Tj 0 Tc 6.3001 0 0 6.3001 229.9 376.56 Tm (4 )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf 0.0307 Tc 10.6 0 0 10.6 235.57 379.93 Tm (ae)Tj 0.161 0.161 0.153 rg -0.035 Tc 9.6278 0 0 10.6 245.27 379.93 Tm (ro)Tj 0.337 0.337 0.329 rg 10.4254 0 0 10.6 253.29 379.93 Tm (so)Tj 0.161 0.161 0.153 rg 0 Tc 10.6 0 0 10.6 262.47 379.93 Tm (l )Tj 0.337 0.337 0.329 rg -0.035 Tc 10.3825 0 0 10.6 268.21 379.93 Tm (as )Tj 0.243 0.247 0.235 rg -0.0194 Tc 10.6 0 0 10.6 46.09 368.89 Tm (before )Tj 0.161 0.161 0.153 rg -0.035 Tc 10.5732 0 0 10.6 76.69 368.89 Tm (and )Tj -0.0265 Tc 10.6 0 0 10.6 95.91 368.89 Tm (immediately )Tj -0.0244 Tc 5.16 0 Td (afterwards )Tj 0 Tc 4.392 0 Td (a )Tj 0.243 0.247 0.235 rg -0.0262 Tc 0.905 0 Td (further )Tj -0.035 Tc 10.5062 0 0 10.6 238.41 368.89 Tm (scan )Tj 0.161 0.161 0.153 rg -0.0276 Tc 10.6 0 0 10.6 260.62 368.89 Tm (was )Tj 0.243 0.247 0.235 rg -0.0229 Tc -20.249 -1.042 Td (obtained. )Tj 0.161 0.161 0.153 rg /T1_1 1 Tf 0.05 Tc 9.8533 0 0 9.4 87.09 357.84 Tm (In )Tj 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0127 Tc 10.6 0 0 10.6 99.26 357.84 Tm (order )Tj 0.161 0.161 0.153 rg -0.035 Tc 9.7344 0 0 10.6 124.78 357.84 Tm (to )Tj -0.0265 Tc 10.6 0 0 10.6 136.22 357.84 Tm (define )Tj -0.035 Tc 10.4562 0 0 10.6 165.57 357.84 Tm (the )Tj -0.0288 Tc 10.6 0 0 10.6 181.35 357.84 Tm (lung )Tj 0.243 0.247 0.235 rg -0.0233 Tc 2.002 0 Td (boundaries )Tj 0.161 0.161 0.153 rg -0.035 Tc 10.2207 0 0 10.6 250.46 357.84 Tm (and )Tj 10.3833 0 0 10.6 268.77 357.84 Tm (to )Tj -0.0214 Tc 10.6 0 0 10.6 45.98 347.28 Tm (quantify )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.4562 0 0 10.6 84.93 347.28 Tm (the )Tj -0.019 Tc 10.6 0 0 10.6 101.18 347.28 Tm (dose )Tj 0.337 0.337 0.329 rg 0.0478 Tc 2.174 0 Td (or )Tj 0.243 0.247 0.235 rg -0.0337 Tc 1.267 0 Td (aerosol )Tj -0.035 Tc 9.2582 0 0 10.6 171.76 347.28 Tm (in )Tj 9.0854 0 0 10.6 184.3 347.28 Tm (th)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 191.41 347.28 Tm (e )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.5673 0 0 10.6 201.03 347.28 Tm (lungs, )Tj 0 Tc 10.6 0 0 10.6 229.33 347.28 Tm (a )Tj 0.161 0.161 0.153 rg -0.0292 Tc 0.873 0 Td (perfusion )Tj 0.337 0.337 0.329 rg -0.0248 Tc -18.175 -1.041 Td (scan )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.235 0 0 10.6 69.59 336.25 Tm (wa)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 81.45 336.25 Tm (s )Tj 0.243 0.247 0.235 rg -0.0323 Tc 0.831 0 Td (performed )Tj 0.0156 Tc 4.425 0 Td (at )Tj 0.161 0.161 0.153 rg -0.035 Tc 10.3833 0 0 10.6 150.21 336.25 Tm (th)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 157.81 336.25 Tm (e )Tj -0.0324 Tc 0.906 0 Td (end )Tj 0.05 Tc 11.1292 0 0 10.6 187.09 336.25 Tm (of )Tj 0.243 0.247 0.235 rg -0.0295 Tc 10.6 0 0 10.6 201.01 336.25 Tm (each )Tj -0.0258 Tc 2.215 0 Td (study )Tj -0.035 Tc 10.5506 0 0 10.6 251.53 336.25 Tm (by )Tj 0.161 0.161 0.153 rg 10.1679 0 0 10.6 266.78 336.25 Tm (an )Tj 0.243 0.247 0.235 rg -0.0302 Tc 10.6 0 0 10.6 46.47 325.69 Tm (intravenou)Tj 0.4 0.4 0.392 rg 0 Tc 3.979 0 Td (s )Tj 0.161 0.161 0.153 rg -0.035 Tc 9.9189 0 0 10.6 96.88 325.69 Tm (inj)Tj 0.337 0.337 0.329 rg -0.0312 Tc 10.6 0 0 10.6 107.41 325.69 Tm (ection )Tj 0.243 0.247 0.235 rg 0.0025 Tc 2.627 0 Td (of )Tj 0.337 0.337 0.329 rg -0.0227 Tc 1.086 0 Td (approximate)Tj 0.161 0.161 0.153 rg -0.035 Tc 9.2467 0 0 10.6 197.68 325.69 Tm (ly )Tj 9.5256 0 0 10.6 209.43 325.69 Tm (1.5 )Tj 0.243 0.247 0.235 rg 10.2597 0 0 10.6 224.14 325.69 Tm (mC)Tj 0.078 0.078 0.071 rg 0 Tc 10.6 0 0 10.6 238.95 325.69 Tm (i )Tj ET BT /Suspect <>BDC 0.161 0.161 0.153 rg /T1_0 1 Tf 6.1 0 0 6.1 244.73 328.56 Tm (9)Tj -0.035 Tc 9.5457 0 0 10.6 247.57 325.69 Tm (9mTc0)Tj 0 Tc 6.1 0 0 6.1 273.1 322.33 Tm (4 )Tj EMC /Suspect <>BDC 0.243 0.247 0.235 rg -0.0288 Tc 10.6 0 0 10.6 46.47 314.65 Tm (labelled )Tj EMC ET BT /T1_0 1 Tf -0.0252 Tc 10.6 0 0 10.6 83.9834 314.65 Tm (macroaggregatcd )Tj 0.337 0.337 0.329 rg -0.0231 Tc 7.056 0 Td (albumin )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 9.4273 0 0 10.6 197.65 314.65 Tm (\(99mTc-MAA\). )Tj EMC ET BT 0.161 0.161 0.153 rg /T1_0 1 Tf 0.0015 Tc 10.6 0 0 10.6 260.07 314.65 Tm (The )Tj -0.0253 Tc -20.186 -1.042 Td (position )Tj 0.243 0.247 0.235 rg 0.0478 Tc 3.43 0 Td (of )Tj 0.161 0.161 0.153 rg -0.0201 Tc 1.184 0 Td (the )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0156 Tc 10.6 0 0 10.6 111.3732 303.6048 Tm (poste)Tj 0.078 0.078 0.071 rg -0.035 Tc 10.0227 0 0 10.6 132.95 303.61 Tm (ri)Tj 0.243 0.247 0.235 rg 0.0025 Tc 10.6 0 0 10.6 139.1 303.61 Tm (or )Tj EMC ET BT 0.161 0.161 0.153 rg /T1_0 1 Tf -0.035 Tc 10.5066 0 0 10.6 151.65 303.61 Tm (thorax )Tj -0.02 Tc 10.6 0 0 10.6 180.94 303.61 Tm (relative )Tj -0.035 Tc 10.3833 0 0 10.6 215.49 303.61 Tm (to )Tj 10.4562 0 0 10.6 227.49 303.61 Tm (the )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf 10.4304 0 0 10.6 243.75 303.61 Tm (gamma\255)Tj EMC ET BT /T1_0 1 Tf -0.0199 Tc 10.6 0 0 10.6 45.5 292.56 Tm (camera )Tj 0.161 0.161 0.153 rg -0.035 Tc 10.3816 0 0 10.6 80.63 292.56 Tm (was )Tj 0.243 0.247 0.235 rg -0.0313 Tc 10.6 0 0 10.6 100.68 292.56 Tm (fixed )Tj -0.0266 Tc 2.491 0 Td (for )Tj -0.035 Tc 10.4562 0 0 10.6 144.45 292.56 Tm (the )Tj -0.0334 Tc 10.6 0 0 10.6 161.64 292.56 Tm (four )Tj -0.0253 Tc 2.035 0 Td (scans )Tj 0.161 0.161 0.153 rg -0.035 Tc 10.5506 0 0 10.6 210.25 292.56 Tm (by )Tj -0.0335 Tc 10.6 0 0 10.6 225.58 292.56 Tm (marking )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.4562 0 0 10.6 264.45 292.56 Tm (the )Tj -0.0188 Tc 10.6 0 0 10.6 45.62 282 Tm (position )Tj 0.05 Tc 11.1292 0 0 10.6 81.97 282 Tm (of )Tj 0.161 0.161 0.153 rg -0.0295 Tc 10.6 0 0 10.6 94.57 282 Tm (bony )Tj -0.0259 Tc 2.3 0 Td (landmarks )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.1631 0 0 10.6 165.02 282 Tm (on )Tj 0.161 0.161 0.153 rg 10.4562 0 0 10.6 179.01 282 Tm (the )Tj 0.243 0.247 0.235 rg -0.0157 Tc 10.6 0 0 10.6 194.9 282 Tm (poster)Tj 0.078 0.078 0.071 rg -0.0262 Tc 2.344 0 Td (ior )Tj 0.243 0.247 0.235 rg -0.0212 Tc 1.403 0 Td (chest )Tj 0.161 0.161 0.153 rg -0.0281 Tc 2.317 0 Td (wall )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.3688 0 0 10.6 46.07 270.97 Tm (with )Tj 0 Tc 10.6 0 0 10.6 67.57 270.97 Tm (a )Tj 0.161 0.161 0.153 rg -0.0224 Tc 0.778 0 Td (radioactive )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0227 Tc 10.6 0 0 10.6 123.856 270.97 Tm (poi)Tj 0.078 0.078 0.071 rg 0 Tc 1.265 0 Td (n)Tj 0.243 0.247 0.235 rg -0.035 Tc 10.4379 0 0 10.6 142.53 270.97 Tm (ter. )Tj EMC ET BT /T1_3 1 Tf -0.0163 Tc 10.7 0 0 10.7 45.28 247.44 Tm (Aerosol )Tj -0.0216 Tc 3.249 0 Td (production )Tj -0.0278 Tc 4.58 0 Td (and )Tj 0.161 0.161 0.153 rg -0.0259 Tc 1.75 0 Td (delivery )Tj 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 10.42 0 0 10.6 55.18 225.37 Tm (Aerosol)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 86.25 225.37 Tm (s )Tj 0.243 0.247 0.235 rg -0.0266 Tc 0.827 0 Td (were )Tj 0.337 0.337 0.329 rg -0.0306 Tc 2.303 0 Td (generated )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.0797 0 0 10.6 163.09 225.37 Tm (from )Tj 0 Tc 10.6 0 0 10.6 187.09 225.37 Tm (a )Tj -0.0183 Tc 0.866 0 Td (Hudson')Tj 0.4 0.4 0.392 rg 0 Tc 3.251 0 Td (s )Tj 0.161 0.161 0.153 rg 0.828 0 Td (n)Tj 0.337 0.337 0.329 rg -0.035 Tc 10.5313 0 0 10.6 243.73 225.37 Tm (ebul)Tj 0.161 0.161 0.153 rg 0 Tc 10.6 0 0 10.6 261.51 225.37 Tm (i)Tj 0.337 0.337 0.329 rg -0.035 Tc 10.2827 0 0 10.6 263.94 225.37 Tm (ze)Tj 0.161 0.161 0.153 rg 0 Tc 10.6 0 0 10.6 273.1 225.37 Tm (r )Tj 0.337 0.337 0.329 rg -0.035 Tc 10.5361 0 0 10.6 45.5 214.33 Tm (driven )Tj 0.243 0.247 0.235 rg 10.0482 0 0 10.6 74.89 214.33 Tm (by )Tj 0.337 0.337 0.329 rg -0.0338 Tc 10.6 0 0 10.6 88.22 214.33 Tm (compressed )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf 0.0124 Tc 9.9 0 0 9.9 139.1 214.33 Tm (air)Tj 0.4 0.4 0.392 rg 0 Tc 1.104 0 Td (. )Tj EMC /Suspect <>BDC 0.243 0.247 0.235 rg -0.035 Tc 10.1739 0 0 10.6 156.46 214.33 Tm (Aero)Tj 0.4 0.4 0.392 rg 10.4254 0 0 10.6 175.53 214.33 Tm (so)Tj 0.243 0.247 0.235 rg 0 Tc 10.6 0 0 10.6 184.71 214.33 Tm (l )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.4464 0 0 10.6 191.5 214.33 Tm (mass-median )Tj -0.0317 Tc 10.6 0 0 10.6 247.22 214.33 Tm (particle )Tj 0.337 0.337 0.329 rg -0.0252 Tc -19.03 -1.042 Td (diameter, )Tj 0.243 0.247 0.235 rg -0.0287 Tc 3.992 0 Td (measured )Tj -0.035 Tc 8.8025 0 0 10.6 131.03 203.29 Tm (witl1 )Tj 0 Tc 10.6 0 0 10.6 152.53 203.29 Tm (a )Tj 0.4 0.4 0.392 rg -0.0248 Tc 0.811 0 Td (seve)Tj 0.243 0.247 0.235 rg -0.035 Tc 9.6641 0 0 10.6 179.51 203.29 Tm (n-)Tj 0.4 0.4 0.392 rg -0.0298 Tc 10.6 0 0 10.6 187.53 203.29 Tm (stag)Tj 0.243 0.247 0.235 rg 0 Tc 1.498 0 Td (e )Tj -0.0221 Tc 0.866 0 Td (Batelle )Tj 0.337 0.337 0.329 rg -0.0234 Tc 3.075 0 Td (cascade )Tj 0.243 0.247 0.235 rg -0.0258 Tc -18.837 -0.996 Td (impactor, )Tj -0.035 Tc 9.8086 0 0 10.6 88.31 192.73 Tm (wa)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 99.69 192.73 Tm (s )Tj 0.337 0.337 0.329 rg -0.035 Tc 10.5566 0 0 10.6 107.46 192.73 Tm (2.8\2612.1 )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /C0_0 1 Tf 0 Tc 13.44 0 0 7.68 142.09 192.73 Tm <007E0020>Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf -0.0257 Tc 10.6 0 0 10.6 160.19 192.73 Tm (\(geometric )Tj 0.243 0.247 0.235 rg 0 Tc 4.493 0 Td (m)Tj 0.4 0.4 0.392 rg -0.035 Tc 9.7884 0 0 10.6 214.94 192.73 Tm (ean\261GSD\). )Tj 0.243 0.247 0.235 rg -0.0211 Tc 10.6 0 0 10.6 260.55 192.73 Tm (The )Tj -0.035 Tc 10.1629 0 0 10.6 45.59 181.69 Tm (noz)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 59.94 181.69 Tm (z)Tj 0.243 0.247 0.235 rg -0.035 Tc 10.0336 0 0 10.6 64.72 181.69 Tm (le )Tj 0.337 0.337 0.329 rg 0.0478 Tc 10.6 0 0 10.6 76.7 181.69 Tm (of )Tj 0.243 0.247 0.235 rg -0.035 Tc 9.0854 0 0 10.6 90.7 181.69 Tm (th)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 97.81 181.69 Tm (e )Tj 0.161 0.161 0.153 rg 0.96 0 Td (n)Tj 0.337 0.337 0.329 rg -0.035 Tc 10.5313 0 0 10.6 112.69 181.69 Tm (ebul)Tj 0.161 0.161 0.153 rg 0 Tc 10.6 0 0 10.6 130.47 181.69 Tm (i)Tj 0.4 0.4 0.392 rg -0.0149 Tc 0.229 0 Td (ze)Tj 0.243 0.247 0.235 rg 0 Tc 0.864 0 Td (r )Tj 0.337 0.337 0.329 rg -0.035 Tc 10.3816 0 0 10.6 150.71 181.69 Tm (was )Tj 0.4 0.4 0.392 rg 10.271 0 0 10.6 171.26 181.69 Tm (co)Tj 0.243 0.247 0.235 rg -0.0305 Tc 10.6 0 0 10.6 180.95 181.69 Tm (nnect)Tj 0.4 0.4 0.392 rg 0 Tc 2.028 0 Td (e)Tj 0.243 0.247 0.235 rg 0.408 0 Td (d )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.3833 0 0 10.6 217.41 181.69 Tm (to )Tj EMC ET BT /T1_0 1 Tf 10.0379 0 0 10.6 230.38 181.69 Tm (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.558 0 0 10.6 247.18 181.69 Tm (mouth)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 273 181.69 Tm (\255)Tj EMC ET BT 0.161 0.161 0.153 rg /T1_0 1 Tf -0.0148 Tc 10.6 0 0 10.6 45.1424 170.6448 Tm (piece )Tj -0.035 Tc 10.0482 0 0 10.6 73.45 170.65 Tm (by )Tj 0.243 0.247 0.235 rg 0 Tc 10.6 0 0 10.6 90.13 170.65 Tm (a )Tj 0.161 0.161 0.153 rg -0.0292 Tc 1.094 0 Td (tube )Tj 0.243 0.247 0.235 rg -0.0122 Tc 2.301 0 Td (36 )Tj -0.035 Tc 9.8864 0 0 10.6 142.93 170.65 Tm (em )Tj 9.9195 0 0 10.6 162.16 170.65 Tm (in )Tj -0.0254 Tc 10.6 0 0 10.6 176.55 170.65 Tm (length )Tj -0.035 Tc 10.5732 0 0 10.6 208.69 170.65 Tm (and )Tj 10.4978 0 0 10.6 229.8 170.65 Tm (3.8 )Tj 10.2983 0 0 10.6 249.01 170.65 Tm (em )Tj 0.161 0.161 0.153 rg 9.2582 0 0 10.6 268.72 170.65 Tm (in )Tj 0.243 0.247 0.235 rg -0.0195 Tc 10.6 0 0 10.6 45.02 159.61 Tm (diamete)Tj 0.078 0.078 0.071 rg 0 Tc 3.042 0 Td (r)Tj 0.243 0.247 0.235 rg 0.343 0 Td (. )Tj 0.161 0.161 0.153 rg -0.0211 Tc 0.646 0 Td (The )Tj -0.0226 Tc 2 0 Td (nebulizer )Tj -0.0276 Tc 3.984 0 Td (was )Tj -0.0259 Tc 1.946 0 Td (triggered )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.0482 0 0 10.6 213.13 159.61 Tm (by )Tj 0.161 0.161 0.153 rg 10.5668 0 0 10.6 227.98 159.61 Tm (means )Tj 0.243 0.247 0.235 rg 0.0478 Tc 10.6 0 0 10.6 258.14 159.61 Tm (of )Tj 0 Tc 1.267 0 Td (a )Tj -0.035 Tc 10.544 0 0 10.6 45.02 148.57 Tm (do)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 55.53 148.57 Tm (s)Tj 0.243 0.247 0.235 rg -0.0177 Tc 0.323 0 Td (imeter)Tj 0.506 0.506 0.494 rg 0 Tc 2.483 0 Td (, )Tj 0.243 0.247 0.235 rg -0.035 Tc 9.5458 0 0 10.6 92.17 148.57 Tm (by )Tj -0.0201 Tc 10.6 0 0 10.6 106.05 148.57 Tm (the )Tj -0.035 Tc 10.0306 0 0 10.6 122.77 148.57 Tm (fall )Tj 9.9195 0 0 10.6 140.08 148.57 Tm (in )Tj 10.4562 0 0 10.6 152.13 148.57 Tm (the )Tj -0.0292 Tc 10.6 0 0 10.6 168.45 148.57 Tm (tube )Tj -0.035 Tc 10.3423 0 0 10.6 190.1 148.57 Tm (pr)Tj 0.4 0.4 0.392 rg -0.0119 Tc 10.6 0 0 10.6 197.65 148.57 Tm (ess)Tj 0.243 0.247 0.235 rg -0.035 Tc 10.3535 0 0 10.6 210.72 148.57 Tm (ure )Tj 0.337 0.337 0.329 rg 9.9712 0 0 10.6 227.42 148.57 Tm (at )Tj 0.243 0.247 0.235 rg 10.4562 0 0 10.6 239.01 148.57 Tm (the )Tj 0.337 0.337 0.329 rg -0.0127 Tc 10.6 0 0 10.6 254.78 148.57 Tm (onset )Tj 0.0478 Tc -19.789 -1.042 Td (of )Tj 0.243 0.247 0.235 rg -0.035 Tc 9.2582 0 0 10.6 59.92 137.52 Tm (in)Tj 0.4 0.4 0.392 rg 0.0183 Tc 10.6 0 0 10.6 67.05 137.52 Tm (spi)Tj 0.243 0.247 0.235 rg -0.0224 Tc 1.144 0 Td (ration, )Tj 0.337 0.337 0.329 rg -0.035 Tc 10.2207 0 0 10.6 111.26 137.52 Tm (and )Tj 0.243 0.247 0.235 rg -0.0245 Tc 10.6 0 0 10.6 131.99 137.52 Tm (nebulization )Tj 0.337 0.337 0.329 rg -0.0202 Tc 5.244 0 Td (continued )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.33 0 0 10.6 233.65 137.52 Tm (for )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf -0.0255 Tc 10.6 0 0 10.6 250.93 137.52 Tm (0.6 )Tj EMC ET BT 0.4 0.4 0.392 rg /T1_0 1 Tf -0.035 Tc 9.9525 0 0 10.6 269.62 137.52 Tm (s. )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0258 Tc 10.6 0 0 10.6 44.93 126.96 Tm (Subjects )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.483 0 0 10.6 83.03 126.96 Tm (were )Tj 0 Tc 10.6 0 0 10.6 105.97 126.96 Tm (a)Tj 0.4 0.4 0.392 rg 0.358 0 Td (s)Tj 0.243 0.247 0.235 rg -0.035 Tc 10.1451 0 0 10.6 114.7 126.96 Tm (ked )Tj /T1_1 1 Tf 0.0215 Tc 8.5 0 0 8.5 132.92 126.96 Tm (to )Tj /T1_0 1 Tf -0.0319 Tc 10.6 0 0 10.6 144.39 126.96 Tm (inhale )Tj -0.0297 Tc 2.625 0 Td (at )Tj 0.337 0.337 0.329 rg 0 Tc 1.042 0 Td (a )Tj 0.4 0.4 0.392 rg 0.766 0 Td (s)Tj 0.243 0.247 0.235 rg -0.035 Tc 10.1857 0 0 10.6 195.75 126.96 Tm (low )Tj 9.7691 0 0 10.6 214.55 126.96 Tm (rat)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 224.05 126.96 Tm (e )Tj 0.337 0.337 0.329 rg -0.035 Tc 9.8213 0 0 10.6 233.17 126.96 Tm (from )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf 10.2237 0 0 10.6 255.73 126.96 Tm (func)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 273.48 126.96 Tm (\255)Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 10.5311 0 0 10.6 45.09 115.93 Tm (tional )Tj -0.0247 Tc 10.6 0 0 10.6 73.42 115.93 Tm (residual )Tj 0.337 0.337 0.329 rg -0.0259 Tc 3.57 0 Td (capacity )Tj /T1_1 1 Tf -0.0227 Tc 9.6 0 0 9.6 150.55 115.93 Tm (\(FRC\) )Tj /T1_0 1 Tf -0.035 Tc 9.7344 0 0 10.6 182.38 115.93 Tm (to )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf 10.2964 0 0 10.6 195.81 115.93 Tm (total )Tj EMC ET BT 0.161 0.161 0.153 rg /T1_0 1 Tf 10.0693 0 0 10.6 219.28 115.93 Tm (lun)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 231.75 115.93 Tm (g )Tj -0.0259 Tc 0.995 0 Td (capacity )Tj -0.0333 Tc -18.614 -1.042 Td (\(TLC\) )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.5732 0 0 10.6 75.73 104.89 Tm (and )Tj 9.7344 0 0 10.6 96.46 104.89 Tm (to )Tj 0.337 0.337 0.329 rg -0.0101 Tc 10.6 0 0 10.6 108.85 104.89 Tm (exhale )Tj -0.0298 Tc 3.075 0 Td (slowly )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.3833 0 0 10.6 173.73 104.89 Tm (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.1286 0 0 10.6 187.16 104.89 Tm (FRC )Tj EMC ET BT /T1_0 1 Tf -0.0326 Tc 10.6 0 0 10.6 211.66 104.89 Tm (without )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.5911 0 0 10.6 247.69 104.89 Tm (breath)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 272.52 104.89 Tm (\255)Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0329 Tc 10.6 0 0 10.6 45.097 93.8448 Tm (holding)Tj 0.4 0.4 0.392 rg 0 Tc 2.879 0 Td (. )Tj 0.243 0.247 0.235 rg -0.0129 Tc 0.646 0 Td (This )Tj -0.0268 Tc 2.18 0 Td (manoeuvr)Tj 0.4 0.4 0.392 rg 0 Tc 3.75 0 Td (e )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.3816 0 0 10.6 155.03 93.84 Tm (was )Tj 10.4262 0 0 10.6 175.22 93.84 Tm (pra)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 188.06 93.84 Tm (c)Tj 0.243 0.247 0.235 rg -0.035 Tc 9.9236 0 0 10.6 192.94 93.84 Tm (tis)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 201.49 93.84 Tm (e)Tj 0.243 0.247 0.235 rg 0.454 0 Td (d )Tj -0.035 Tc 10.0482 0 0 10.6 216.49 93.84 Tm (by )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.4562 0 0 10.6 230.85 93.84 Tm (the )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf -0.0253 Tc 10.6 0 0 10.6 247.05 93.84 Tm (subjec)Tj 0.161 0.161 0.153 rg 0 Tc 2.502 0 Td (t )Tj -0.0194 Tc -21.596 -1.042 Td (before )Tj -0.035 Tc 10.4562 0 0 10.6 74.37 82.8 Tm (the )Tj 0.243 0.247 0.235 rg -0.0159 Tc 10.6 0 0 10.6 90.57 82.8 Tm (start )Tj 0.05 Tc 11.1292 0 0 10.6 111.25 82.8 Tm (of )Tj -0.0144 Tc 10.6 0 0 10.6 123.25 82.8 Tm (each )Tj -0.024 Tc 2.128 0 Td (experiment. )Tj /T1_3 1 Tf -0.035 Tc 10.5806 0 0 10.7 298.67 738.97 Tm (Lung )Tj -0.0157 Tc 10.7 0 0 10.7 322.59 738.97 Tm (scans )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.5846 0 0 10.6 307.49 716.41 Tm (Seven )Tj EMC ET BT 0.161 0.161 0.153 rg /T1_0 1 Tf 9.9355 0 0 10.6 337.9 716.41 Tm (ml )Tj 0.243 0.247 0.235 rg 0.0478 Tc 10.6 0 0 10.6 353.18 716.41 Tm (of )Tj 0 Tc 6.4001 0 0 6.4001 367.13 719.29 Tm (9)Tj -0.035 Tc 9.7923 0 0 10.6 369.97 716.41 Tm (9mTechnetium )Tj -0.0163 Tc 10.6 0 0 10.6 431.06 716.41 Tm (pertechnetate )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.2252 0 0 10.6 490.93 716.41 Tm (\(99mTc0)Tj 0 Tc 6.4001 0 0 6.4001 522.21 713.05 Tm (4)Tj 0.509 0.525 Td (; )Tj EMC ET BT 0.161 0.161 0.153 rg /T1_0 1 Tf -0.0271 Tc 10.6 0 0 10.6 298.45 705.85 Tm (approximately )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf 0.0115 Tc 10.6 0 0 10.6 362.3574 705.85 Tm (40 )Tj EMC ET BT 0.161 0.161 0.153 rg /T1_0 1 Tf -0.035 Tc 9.9177 0 0 10.6 379.66 705.85 Tm (mCi )Tj -0.0222 Tc 10.6 0 0 10.6 403.22 705.85 Tm (per )Tj -0.035 Tc 10.2397 0 0 10.6 422.38 705.85 Tm (ml\) )Tj 10.483 0 0 10.6 443.03 705.85 Tm (were )Tj 0.243 0.247 0.235 rg -0.0213 Tc 10.6 0 0 10.6 468.98 705.85 Tm (placed )Tj 0.078 0.078 0.071 rg -0.035 Tc 9.2582 0 0 10.6 502.48 705.85 Tm (in )Tj 0.243 0.247 0.235 rg 10.4562 0 0 10.6 516.45 705.85 Tm (the )Tj -0.0131 Tc 10.6 0 0 10.6 298.51 694.8 Tm (Hudson's )Tj 0.161 0.161 0.153 rg -0.0282 Tc 3.943 0 Td (nebulizer )Tj -0.032 Tc 3.803 0 Td (which )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.3816 0 0 10.6 408.95 694.8 Tm (was )Tj -0.0145 Tc 10.6 0 0 10.6 427.66 694.8 Tm (kept )Tj 0.161 0.161 0.153 rg -0.035 Tc 9.9195 0 0 10.6 449.2 694.8 Tm (in )Tj 0.243 0.247 0.235 rg 0 Tc 10.6 0 0 10.6 460.21 694.8 Tm (a )Tj 0.161 0.161 0.153 rg -0.0209 Tc 0.817 0 Td (lead )Tj 0.243 0.247 0.235 rg -0.0309 Tc 1.901 0 Td (container. )Tj -0.035 Tc 10.4736 0 0 10.6 298.47 684.24 Tm (The )Tj 0.337 0.337 0.329 rg -0.022 Tc 10.6 0 0 10.6 318.57 684.24 Tm (subject )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.3816 0 0 10.6 351.35 684.24 Tm (was )Tj 0.337 0.337 0.329 rg -0.023 Tc 10.6 0 0 10.6 370.41 684.24 Tm (seated )Tj 0.243 0.247 0.235 rg -0.0282 Tc 2.822 0 Td (upright )Tj -0.035 Tc 10.3688 0 0 10.6 433.43 684.24 Tm (with )Tj 10.4562 0 0 10.6 455.97 684.24 Tm (the )Tj 0.337 0.337 0.329 rg -0.0183 Tc 10.6 0 0 10.6 472.34 684.24 Tm (posterior )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 9.7344 0 0 10.6 512.62 684.24 Tm (th)Tj 0.4 0.4 0.392 rg 9.8766 0 0 10.6 520.23 684.24 Tm (o\255)Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf 9.9528 0 0 10.6 299.03 673.21 Tm (rax )Tj 10.5234 0 0 10.6 314.86 673.21 Tm (resting )Tj -0.0319 Tc 10.6 0 0 10.6 345.01 673.21 Tm (against )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.4562 0 0 10.6 376.29 673.21 Tm (the )Tj EMC ET BT /T1_0 1 Tf -0.0285 Tc 10.6 0 0 10.6 391.7 673.21 Tm (paralle)Tj 0.078 0.078 0.071 rg 0 Tc 2.525 0 Td (l)Tj 0.4 0.4 0.392 rg 0.224 0 Td (-)Tj 0.161 0.161 0.153 rg 0.326 0 Td (h)Tj 0.337 0.337 0.329 rg -0.0338 Tc 0.445 0 Td (ole )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0173 Tc 10.6 0 0 10.6 444.3714 673.21 Tm (co)Tj 0.161 0.161 0.153 rg -0.035 Tc 10.4225 0 0 10.6 454.54 673.21 Tm (mmat)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 477.02 673.21 Tm (o)Tj 0.161 0.161 0.153 rg 0.506 0 Td (r )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf 0.0478 Tc 10.6 0 0 10.6 489.0192 673.21 Tm (of )Tj 0 Tc 1.131 0 Td (a )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 10.1698 0 0 10.6 509.67 673.21 Tm (large )Tj EMC ET BT /T1_0 1 Tf 10.3909 0 0 10.6 298.92 662.17 Tm (field )Tj 0.05 Tc 11.1292 0 0 10.6 321.97 662.17 Tm (of )Tj -0.035 Tc 10.2212 0 0 10.6 336.46 662.17 Tm (view )Tj 0.337 0.337 0.329 rg -0.0313 Tc 10.6 0 0 10.6 360.39 662.17 Tm (gamma-camera )Tj -0.0177 Tc 6.336 0 Td (\(Nuclear )Tj -0.022 Tc 3.856 0 Td (Enterprise )Tj -0.035 Tc 10.362 0 0 10.6 515.09 662.17 Tm (NE )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf 10.4547 0 0 10.6 298.86 651.12 Tm (8970\))Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 322.39 651.12 Tm (, )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf -0.035 Tc 10.5732 0 0 10.6 327.73 651.12 Tm (and )Tj 0.243 0.247 0.235 rg 10.4354 0 0 10.6 346.95 651.12 Tm (inhaled )Tj 0.337 0.337 0.329 rg -0.0293 Tc 10.6 0 0 10.6 379.69 651.12 Tm (betwee)Tj 0.161 0.161 0.153 rg 0 Tc 2.67 0 Td (n )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0229 Tc 10.6 0 0 10.6 416.7476 651.12 Tm (10 )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf -0.035 Tc 10.2207 0 0 10.6 430.46 651.12 Tm (and )Tj 0.243 0.247 0.235 rg -0.0229 Tc 10.6 0 0 10.6 448.91 651.12 Tm (15 )Tj -0.035 Tc 10.5772 0 0 10.6 463.22 651.12 Tm (puffs )Tj 0.337 0.337 0.329 rg 0.0478 Tc 10.6 0 0 10.6 487.58 651.12 Tm (of )Tj -0.0303 Tc 1.131 0 Td (aeroso)Tj 0.078 0.078 0.071 rg 0 Tc 2.492 0 Td (l )Tj 0.337 0.337 0.329 rg -0.0195 Tc -21.468 -0.996 Td (\(depending )Tj 0.243 0.247 0.235 rg -0.035 Tc 9.8818 0 0 10.6 348 640.56 Tm (upon )Tj 10.4562 0 0 10.6 371.49 640.56 Tm (the )Tj -0.0251 Tc 10.6 0 0 10.6 387.25 640.56 Tm (activity )Tj 0.337 0.337 0.329 rg 0.0025 Tc 3.216 0 Td (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 6.4001 0 0 6.4001 432.89 643.92 Tm (9)Tj -0.035 Tc 9.9226 0 0 10.6 436.21 640.56 Tm (9mTcOJ )Tj EMC ET BT /T1_0 1 Tf -0.0116 Tc 10.6 0 0 10.6 472.22 640.56 Tm (over )Tj 0.243 0.247 0.235 rg 0 Tc 2.082 0 Td [(a )-88(p)]TJ 0.4 0.4 0.392 rg 1.268 0 Td (e)Tj 0.243 0.247 0.235 rg -0.035 Tc 10.2081 0 0 10.6 512.63 640.56 Tm (riod )Tj 0.0478 Tc 10.6 0 0 10.6 298.46 629.53 Tm (of )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf -0.035 Tc 10.3438 0 0 10.6 311.4 629.53 Tm (30 )Tj EMC ET BT /T1_0 1 Tf 9.9525 0 0 10.6 325.78 629.53 Tm (s. )Tj 0.243 0.247 0.235 rg -0.0323 Tc 10.6 0 0 10.6 336.41 629.53 Tm (Immediately )Tj -0.0243 Tc 5.158 0 Td (after )Tj ET BT /Suspect <>BDC 0.161 0.161 0.153 rg /T1_0 1 Tf -0.035 Tc 9.7795 0 0 10.6 414.22 629.53 Tm (thl)Tj 0.337 0.337 0.329 rg -0.0251 Tc 10.6 0 0 10.6 424.17 629.53 Tm (s, )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 435.247 629.53 Tm (a )Tj 0.337 0.337 0.329 rg -0.035 Tc 10.5062 0 0 10.6 444.33 629.53 Tm (scan )Tj 0.243 0.247 0.235 rg 10.0572 0 0 10.6 467.03 629.53 Tm (was )Tj 0.337 0.337 0.329 rg -0.0267 Tc 10.6 0 0 10.6 486.26 629.53 Tm (performed )Tj -17.717 -1.042 Td (over )Tj 0.243 0.247 0.235 rg 0 Tc 2.037 0 Td (a )Tj 0.337 0.337 0.329 rg -0.035 Tc 10.5362 0 0 10.6 328.82 618.48 Tm (period )Tj 0.0478 Tc 10.6 0 0 10.6 357.98 618.48 Tm (of )Tj 0 Tc 1.175 0 Td (3 )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 10.3816 0 0 10.6 379.18 618.48 Tm (min)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 395.3 618.48 Tm (. )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 8.9769 0 0 10.6 401.2 618.48 Tm (TI1e )Tj -0.023 Tc 10.6 0 0 10.6 420.86 618.48 Tm (data )Tj -0.0239 Tc 1.946 0 Td (acquired )Tj -0.0266 Tc 3.722 0 Td (were )Tj 0.337 0.337 0.329 rg -0.0215 Tc 2.161 0 Td (stored )Tj -0.035 Tc 10.1631 0 0 10.6 298.46 607.44 Tm (on )Tj 0.243 0.247 0.235 rg 10.1648 0 0 10.6 315.82 607.44 Tm (ma)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 327.75 607.44 Tm (g)Tj 0.243 0.247 0.235 rg 0.551 0 Td (n)Tj 0.4 0.4 0.392 rg 0.398 0 Td (e)Tj 0.243 0.247 0.235 rg -0.035 Tc 9.2906 0 0 10.6 342.7 607.44 Tm (ti)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 347.9 607.44 Tm (c )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.4908 0 0 10.6 359.97 607.44 Tm (tape )Tj 10.33 0 0 10.6 383.89 607.44 Tm (for )Tj -0.024 Tc 10.6 0 0 10.6 402.62 607.44 Tm (off-line )Tj 0.337 0.337 0.329 rg -0.0349 Tc 3.487 0 Td (com)Tj 0.161 0.161 0.153 rg -0.035 Tc 10.0419 0 0 10.6 457.46 607.44 Tm (pu)Tj 0.337 0.337 0.329 rg -0.0272 Tc 10.6 0 0 10.6 467.97 607.44 Tm (ter )Tj 0.243 0.247 0.235 rg -0.0307 Tc 1.68 0 Td (proces)Tj 0.4 0.4 0.392 rg 0 Tc 2.475 0 Td (s)Tj 0.243 0.247 0.235 rg -0.035 Tc 9.2582 0 0 10.6 515.92 607.44 Tm (in)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 523.11 607.44 Tm (g )Tj 0.243 0.247 0.235 rg -0.027 Tc -21.196 -0.995 Td (\(Nodecrest )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.0713 0 0 10.6 346.6 596.89 Tm (NMS)Tj 0.4 0.4 0.392 rg -0.0329 Tc 10.6 0 0 10.6 368.45 596.89 Tm (80\). )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0211 Tc 10.6 0 0 10.6 388.7066 596.89 Tm (The )Tj -0.035 Tc 10.4301 0 0 10.6 409.83 596.89 Tm (lung )Tj 10.5086 0 0 10.6 432.39 596.89 Tm (image)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 456.81 596.89 Tm (s )Tj 0.243 0.247 0.235 rg 0.827 0 Td (w)Tj 0.4 0.4 0.392 rg 0.625 0 Td (e)Tj 0.243 0.247 0.235 rg -0.0059 Tc 0.461 0 Td (re )Tj 0 Tc 1.177 0 Td (k)Tj 0.4 0.4 0.392 rg 0.49 0 Td (e)Tj 0.243 0.247 0.235 rg -0.035 Tc 10.4776 0 0 10.6 499.22 596.89 Tm (pt )Tj 9.2582 0 0 10.6 512.08 596.89 Tm (in )Tj 0 Tc 10.6 0 0 10.6 524.05 596.89 Tm (a )Tj 0.337 0.337 0.329 rg -0.035 Tc 9.76 0 0 10.6 298.44 585.85 Tm (64X64 )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf 10.4797 0 0 10.6 330.22 585.85 Tm (matrix )Tj EMC ET BT /T1_0 1 Tf 10.2207 0 0 10.6 362.3 585.85 Tm (and )Tj 0.337 0.337 0.329 rg -0.0295 Tc 10.6 0 0 10.6 381.97 585.85 Tm (each )Tj -0.0262 Tc 2.309 0 Td (aerosol )Tj 0.4 0.4 0.392 rg -0.035 Tc 10.5734 0 0 10.6 441.45 585.85 Tm (sc)Tj 0.243 0.247 0.235 rg 9.6327 0 0 10.6 450.14 585.85 Tm (an )Tj 0.337 0.337 0.329 rg -0.0244 Tc 10.6 0 0 10.6 465.5 585.85 Tm (contained )Tj ET BT /Suspect <>BDC 0.161 0.161 0.153 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 510.6878 585.85 Tm (t)Tj 0.337 0.337 0.329 rg -0.0243 Tc 0.22 0 Td (otal )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0197 Tc 10.6 0 0 10.6 297.9776 574.8048 Tm (counts )Tj 0.161 0.161 0.153 rg -0.0182 Tc 2.815 0 Td (ranging )Tj -0.035 Tc 10.0797 0 0 10.6 362.77 574.8 Tm (from )Tj ET BT /Suspect <>BDC 0.078 0.078 0.071 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 386.03 574.8 Tm (1)Tj 0.243 0.247 0.235 rg -0.0204 Tc 0.432 0 Td (00,000 )Tj EMC ET BT 0.161 0.161 0.153 rg /T1_0 1 Tf -0.0048 Tc 10.6 0 0 10.6 421.8898 574.8 Tm (to )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0184 Tc 10.6 0 0 10.6 433.4014 574.8 Tm (400,000 )Tj EMC ET BT /T1_0 1 Tf -0.0203 Tc 10.6 0 0 10.6 469.823 574.8 Tm (counts. )Tj -0.0263 Tc -15.346 -1.042 Td (Preliminary )Tj -0.0206 Tc 4.881 0 Td (studies )Tj -0.0237 Tc 3.082 0 Td (failed )Tj -0.035 Tc 9.7344 0 0 10.6 419.5 563.76 Tm (to )Tj 0.161 0.161 0.153 rg -0.0254 Tc 10.6 0 0 10.6 431.9 563.76 Tm (demonstrate )Tj 0.243 0.247 0.235 rg -0.0206 Tc 5.112 0 Td (significant )Tj 0.161 0.161 0.153 rg -0.0344 Tc -17.692 -1.041 Td (uptake )Tj 0.243 0.247 0.235 rg -0.035 Tc 9.9195 0 0 10.6 330.16 552.73 Tm (in )Tj 0.161 0.161 0.153 rg 10.4562 0 0 10.6 343.17 552.73 Tm (the )Tj 0.078 0.078 0.071 rg 9.7344 0 0 10.6 360.46 552.73 Tm (th)Tj 0.243 0.247 0.235 rg -0.0286 Tc 10.6 0 0 10.6 368.15 552.73 Tm (yroid )Tj -0.035 Tc 10.4586 0 0 10.6 394.47 552.73 Tm (gland )Tj 0.161 0.161 0.153 rg 10.5732 0 0 10.6 421.33 552.73 Tm (and )Tj -0.0201 Tc 10.6 0 0 10.6 441.57 552.73 Tm (therefore )Tj -0.035 Tc 10.4815 0 0 10.6 482.87 552.73 Tm (no )Tj 0.243 0.247 0.235 rg -0.0217 Tc 10.6 0 0 10.6 498.13 552.73 Tm (attempt )Tj 0.161 0.161 0.153 rg -0.035 Tc 10.3816 0 0 10.6 298.55 541.68 Tm (was )Tj 10.5184 0 0 10.6 317.74 541.68 Tm (made )Tj 0.243 0.247 0.235 rg 10.3833 0 0 10.6 343.17 541.68 Tm (to )Tj 0.161 0.161 0.153 rg -0.0318 Tc 10.6 0 0 10.6 354.25 541.68 Tm (block )Tj -0.0326 Tc 2.49 0 Td (uptake. )Tj 0.243 0.247 0.235 rg /T1_3 1 Tf -0.0324 Tc 10.7 0 0 10.7 298.41 510.97 Tm (Quantitative )Tj -0.035 Tc 10.4847 0 0 10.7 351.71 510.97 Tm (imag)Tj 0.4 0.4 0.392 rg 0 Tc 10.7 0 0 10.7 371.9 510.97 Tm (e )Tj 0.337 0.337 0.329 rg -0.0244 Tc 0.765 0 Td (analysis )Tj 0.243 0.247 0.235 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 307.18 488.41 Tm (A )Tj 0.337 0.337 0.329 rg -0.035 Tc 10.0127 0 0 10.6 321.5 488.41 Tm (com)Tj 0.161 0.161 0.153 rg 10.4174 0 0 10.6 338.9 488.41 Tm (put)Tj 0.337 0.337 0.329 rg 0.0136 Tc 10.6 0 0 10.6 351.25 488.41 Tm (er )Tj 0.243 0.247 0.235 rg -0.0312 Tc 1.461 0 Td (programme )Tj -0.035 Tc 10.3816 0 0 10.6 419.99 488.41 Tm (was )Tj 10.2874 0 0 10.6 443.04 488.41 Tm (used )Tj 10.3833 0 0 10.6 468.45 488.41 Tm (to )Tj -0.0265 Tc 10.6 0 0 10.6 483.74 488.41 Tm (define )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.4562 0 0 10.6 515.97 488.41 Tm (the )Tj EMC ET BT /T1_0 1 Tf -0.0333 Tc 10.6 0 0 10.6 298.57 477.84 Tm (boundaries )Tj 0.337 0.337 0.329 rg 0.0025 Tc 4.473 0 Td (of )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 10.4562 0 0 10.6 358.53 477.84 Tm (the )Tj EMC ET BT 0.078 0.078 0.071 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 374.79 477.84 Tm (l)Tj 0.243 0.247 0.235 rg -0.035 Tc 10.41 0 0 10.6 377.28 477.84 Tm (ung)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 392.01 477.84 Tm (s )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.0797 0 0 10.6 400.21 477.84 Tm (from )Tj 10.4562 0 0 10.6 423.81 477.84 Tm (the )Tj 0.337 0.337 0.329 rg 10.1447 0 0 10.6 440.18 477.84 Tm (pe)Tj 0.161 0.161 0.153 rg 10.5139 0 0 10.6 449.26 477.84 Tm (rfu)Tj 0.337 0.337 0.329 rg -0.0186 Tc 10.6 0 0 10.6 460.65 477.84 Tm (sion )Tj 0.4 0.4 0.392 rg 0.0091 Tc 1.992 0 Td (sca)Tj 0.243 0.247 0.235 rg 0 Tc 1.236 0 Td (n )Tj 0.078 0.078 0.071 rg 0.853 0 Td (i)Tj 0.243 0.247 0.235 rg -0.035 Tc 10.5184 0 0 10.6 506.86 477.84 Tm (mage )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 298.32 466.81 Tm ([)Tj 0.161 0.161 0.153 rg 0.378 0 Td (1)Tj 0.337 0.337 0.329 rg -0.0216 Tc 0.461 0 Td (0]. )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0211 Tc 10.6 0 0 10.6 320.55 466.81 Tm (The )Tj -0.0347 Tc 1.856 0 Td (dividing )Tj 0.078 0.078 0.071 rg -0.035 Tc 9.5285 0 0 10.6 377.2 466.81 Tm (li)Tj 0.243 0.247 0.235 rg 10.0807 0 0 10.6 382.55 466.81 Tm (ne )Tj 10.5006 0 0 10.6 396.01 466.81 Tm (between )Tj 0.161 0.161 0.153 rg 9.7344 0 0 10.6 432.94 466.81 Tm (th)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 440.53 466.81 Tm (e )Tj 0.243 0.247 0.235 rg -0.0307 Tc 0.817 0 Td (left )Tj -0.035 Tc 10.2207 0 0 10.6 465.98 466.81 Tm (and )Tj -0.0302 Tc 10.6 0 0 10.6 484.3 466.81 Tm (right )Tj 0.161 0.161 0.153 rg -0.035 Tc 9.6665 0 0 10.6 507.28 466.81 Tm (lun)Tj 0.337 0.337 0.329 rg 10.2944 0 0 10.6 519.27 466.81 Tm (gs )Tj 0.243 0.247 0.235 rg 9.8086 0 0 10.6 298.55 456.25 Tm (wa)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 309.93 456.25 Tm (s )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.222 0 0 10.6 318.13 456.25 Tm (fir)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 326.73 456.25 Tm (s)Tj 0.243 0.247 0.235 rg 0.419 0 Td (t )Tj 0.161 0.161 0.153 rg -0.035 Tc 9.2582 0 0 10.6 337.84 456.25 Tm (id)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 345.01 456.25 Tm (e)Tj 0.161 0.161 0.153 rg -0.035 Tc 9.33 0 0 10.6 349.91 456.25 Tm (nLified )Tj 0.337 0.337 0.329 rg 10.3825 0 0 10.6 379.57 456.25 Tm (as )Tj 0.243 0.247 0.235 rg 10.4562 0 0 10.6 392.13 456.25 Tm (the )Tj -0.0245 Tc 10.6 0 0 10.6 408.02 456.25 Tm (point )Tj 0.05 Tc 11.1292 0 0 10.6 431.89 456.25 Tm (of )Tj 0.161 0.161 0.153 rg 0 Tc 10.6 0 0 10.6 444.46 456.25 Tm (m)Tj 0.337 0.337 0.329 rg -0.0297 Tc 0.718 0 Td (inimum )Tj -0.015 Tc 3.305 0 Td (count-rate )Tj 0.243 0.247 0.235 rg -0.035 Tc 9.9195 0 0 10.6 298.48 445.21 Tm (in )Tj ET BT /Suspect <>BDC 0.161 0.161 0.153 rg /T1_0 1 Tf 9.0854 0 0 10.6 311.02 445.21 Tm (th)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 318.13 445.21 Tm (e )Tj EMC /Suspect <>BDC 0.161 0.161 0.153 rg 0.869 0 Td (h)Tj 0.337 0.337 0.329 rg -0.0337 Tc 0.491 0 Td (orizontal )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 372.508 445.21 Tm (p)Tj 0.078 0.078 0.071 rg 0.488 0 Td (l)Tj 0.337 0.337 0.329 rg -0.0309 Tc 0.225 0 Td (ane )Tj -0.035 Tc 10.1515 0 0 10.6 398.89 445.21 Tm (be)Tj 0.161 0.161 0.153 rg 9.4837 0 0 10.6 408.46 445.21 Tm (tw)Tj 0.337 0.337 0.329 rg -0.0059 Tc 10.6 0 0 10.6 417.97 445.21 Tm (ee)Tj 0.161 0.161 0.153 rg 0 Tc 0.87 0 Td (n )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.7344 0 0 10.6 436.78 445.21 Tm (th)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 444.37 445.21 Tm (e )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 10.4301 0 0 10.6 453.57 445.21 Tm (two )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.478 0 0 10.6 473.74 445.21 Tm (maxima. )Tj EMC ET BT /T1_0 1 Tf 10.4294 0 0 10.6 512.07 445.21 Tm (Th)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 523.57 445.21 Tm (e )Tj 0.161 0.161 0.153 rg -0.035 Tc 9.5728 0 0 10.6 298.48 434.16 Tm (im)Tj 0.337 0.337 0.329 rg -0.0309 Tc 10.6 0 0 10.6 308.53 434.16 Tm (age )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.3816 0 0 10.6 328.79 434.16 Tm (was )Tj 9.7344 0 0 10.6 349.9 434.16 Tm (th)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 357.49 434.16 Tm (e)Tj 0.243 0.247 0.235 rg 0.462 0 Td (n )Tj -0.0301 Tc 0.942 0 Td (divided )Tj -0.035 Tc 10.3849 0 0 10.6 409.35 434.16 Tm (into )Tj 10.0936 0 0 10.6 430.54 434.16 Tm (two )Tj 10.0482 0 0 10.6 451.21 434.16 Tm (by )Tj 0 Tc 10.6 0 0 10.6 466.93 434.16 Tm (a )Tj -0.035 Tc 10.5433 0 0 10.6 477.58 434.16 Tm (verti)Tj 0.4 0.4 0.392 rg -0.0056 Tc 10.6 0 0 10.6 495.74 434.16 Tm (ca)Tj 0.243 0.247 0.235 rg 0 Tc 0.861 0 Td (l )Tj 0.161 0.161 0.153 rg -0.035 Tc 9.9097 0 0 10.6 513.52 434.16 Tm (lin)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 523.57 434.16 Tm (e )Tj 0.243 0.247 0.235 rg -0.0315 Tc -21.283 -0.995 Td (along )Tj 0.161 0.161 0.153 rg -0.035 Tc 9.7795 0 0 10.6 323.98 423.61 Tm (thi)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 333.93 423.61 Tm (s )Tj 0.243 0.247 0.235 rg -0.0348 Tc 0.737 0 Td (mid-line. )Tj -0.0068 Tc 3.661 0 Td (To )Tj 0 Tc 1.403 0 Td (d)Tj 0.4 0.4 0.392 rg 0.497 0 Td (e)Tj 0.243 0.247 0.235 rg -0.0332 Tc 0.409 0 Td (lineate )Tj 0.161 0.161 0.153 rg -0.035 Tc 9.0854 0 0 10.6 435.34 423.61 Tm (th)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 442.45 423.61 Tm (e )Tj 0.161 0.161 0.153 rg -0.035 Tc 10.0693 0 0 10.6 451.12 423.61 Tm (lun)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 463.59 423.61 Tm (g )Tj 0.243 0.247 0.235 rg 0.813 0 Td (a )Tj 0.337 0.337 0.329 rg -0.0225 Tc 0.725 0 Td (contour )Tj 0.161 0.161 0.153 rg -0.035 Tc 9.9097 0 0 10.6 514.48 423.61 Tm (lin)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 524.05 423.61 Tm (e )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.3816 0 0 10.6 298.55 412.56 Tm (was )Tj 10.4215 0 0 10.6 317.66 412.56 Tm (drawn )Tj 0.0156 Tc 10.6 0 0 10.6 346.45 412.56 Tm (at )Tj /T1_1 1 Tf -0.035 Tc 8.733 0 0 9.6 358.76 412.56 Tm (18)Tj 0.4 0.4 0.392 rg 0 Tc 9.6 0 0 9.6 368 412.56 Tm (% )Tj 0.337 0.337 0.329 rg /T1_0 1 Tf 0.0478 Tc 10.6 0 0 10.6 380.06 412.56 Tm (of )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.4562 0 0 10.6 392.61 412.56 Tm (the )Tj 10.5095 0 0 10.6 408.46 412.56 Tm (maximum )Tj 0.337 0.337 0.329 rg -0.015 Tc 10.6 0 0 10.6 453.02 412.56 Tm (count-rate )Tj -0.035 Tc 9.2582 0 0 10.6 498.64 412.56 Tm (in )Tj 0.4 0.4 0.392 rg -0.0207 Tc 10.6 0 0 10.6 509.65 412.56 Tm (eac)Tj 0.243 0.247 0.235 rg 0 Tc 1.276 0 Td (h )Tj 0.0119 Tc -21.238 -1.041 Td (half )Tj 0.05 Tc 11.1292 0 0 10.6 317.65 401.53 Tm (of )Tj -0.035 Tc 10.4562 0 0 10.6 331.17 401.53 Tm (the )Tj 10.3728 0 0 10.6 347.91 401.53 Tm (image. )Tj -0.0211 Tc 10.6 0 0 10.6 378.15 401.53 Tm (The )Tj 0.337 0.337 0.329 rg -0.0299 Tc 1.954 0 Td (value )Tj 0 Tc 2.438 0 Td (o)Tj 0.161 0.161 0.153 rg 0.496 0 Td [(f )-208(1)]TJ 0.337 0.337 0.329 rg -0.035 Tc 10.2622 0 0 10.6 442.38 401.53 Tm (8% )Tj 0.243 0.247 0.235 rg 10.3816 0 0 10.6 460.79 401.53 Tm (was )Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 480.38 401.53 Tm (c)Tj 0.243 0.247 0.235 rg -0.035 Tc 9.9886 0 0 10.6 485.27 401.53 Tm (ho)Tj 0.4 0.4 0.392 rg 10.5734 0 0 10.6 495.21 401.53 Tm (se)Tj 0.243 0.247 0.235 rg 0 Tc 10.6 0 0 10.6 503.51 401.53 Tm (n )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf -0.035 Tc 10.1692 0 0 10.6 512.53 401.53 Tm (em\255)Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0271 Tc 10.6 0 0 10.6 298.1 390.49 Tm (pirically; )Tj -0.0293 Tc 3.755 0 Td (values )Tj -0.035 Tc 10.0797 0 0 10.6 367.57 390.49 Tm (from )Tj 0.161 0.161 0.153 rg 0 Tc 10.6 0 0 10.6 391.31 390.49 Tm (1)Tj 0.4 0.4 0.392 rg 0.392 0 Td (2 )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.5732 0 0 10.6 404.05 390.49 Tm (and )Tj 0.337 0.337 0.329 rg 10.4582 0 0 10.6 422.34 390.49 Tm (25% )Tj 10.5985 0 0 10.6 444.87 390.49 Tm (gave )Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 467.37 390.49 Tm (s)Tj 0.243 0.247 0.235 rg -0.0298 Tc 0.458 0 Td (imilar )Tj 0 Tc 2.633 0 Td (r)Tj 0.4 0.4 0.392 rg -0.035 Tc 10.4986 0 0 10.6 502.93 390.49 Tm (es)Tj 0.243 0.247 0.235 rg 9.2126 0 0 10.6 511.68 390.49 Tm (ultS. )Tj 10.4736 0 0 10.6 297.99 379.93 Tm (The )Tj 0.161 0.161 0.153 rg 10.4159 0 0 10.6 318.63 379.93 Tm (lar)Tj 0.337 0.337 0.329 rg -0.0031 Tc 10.6 0 0 10.6 328.23 379.93 Tm (gest )Tj -0.0222 Tc 1.946 0 Td (contiguous )Tj -0.022 Tc 4.573 0 Td (area )Tj 0.243 0.247 0.235 rg -0.035 Tc 9.9195 0 0 10.6 418.96 379.93 Tm (in )Tj 0.337 0.337 0.329 rg -0.0295 Tc 10.6 0 0 10.6 430.45 379.93 Tm (each )Tj 0.243 0.247 0.235 rg -0.0183 Tc 2.227 0 Td (hatf )Tj -0.035 Tc 10.3816 0 0 10.6 474.23 379.93 Tm (was )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.4521 0 0 10.6 493.89 379.93 Tm (taken )Tj EMC /Suspect <>BDC 0.337 0.337 0.329 rg 10.3825 0 0 10.6 519.73 379.93 Tm (as )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf 10.4562 0 0 10.6 298.53 368.89 Tm (the )Tj 0.161 0.161 0.153 rg 10.4301 0 0 10.6 314.79 368.89 Tm (lung)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 332.42 368.89 Tm (. )Tj 0.243 0.247 0.235 rg -0.0291 Tc 0.605 0 Td (Becaus)Tj 0.4 0.4 0.392 rg 0 Tc 2.757 0 Td (e )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.4562 0 0 10.6 376.77 368.89 Tm (the )Tj 0.337 0.337 0.329 rg 10.2984 0 0 10.6 393.51 368.89 Tm (image )Tj 0 Tc 10.6 0 0 10.6 421.82 368.89 Tm (o)Tj 0.161 0.161 0.153 rg 0.496 0 Td (f )Tj 0.243 0.247 0.235 rg -0.0201 Tc 0.688 0 Td (the )Tj -0.0307 Tc 1.625 0 Td (left )Tj -0.035 Tc 10.0693 0 0 10.6 468.88 368.89 Tm (lun)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 481.35 368.89 Tm (g )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.235 0 0 10.6 491.03 368.89 Tm (wa)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 502.41 368.89 Tm (s )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0173 Tc 10.6 0 0 10.6 510.1374 368.89 Tm (co)Tj 0.243 0.247 0.235 rg 0 Tc 0.959 0 Td (n)Tj 0.4 0.4 0.392 rg 0.442 0 Td (\255)Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0333 Tc 10.6 0 0 10.6 298.042 358.3324 Tm (taminated )Tj 0.337 0.337 0.329 rg -0.035 Tc 9.5458 0 0 10.6 341.29 358.33 Tm (by )Tj 0.4 0.4 0.392 rg -0.0173 Tc 10.6 0 0 10.6 354.14 358.33 Tm (co)Tj 0.243 0.247 0.235 rg -0.035 Tc 10.1513 0 0 10.6 364.32 358.33 Tm (unts )Tj 9.5971 0 0 10.6 384.37 358.33 Tm (fr)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 390.62 358.33 Tm (o)Tj 0.243 0.247 0.235 rg 0.506 0 Td (m )Tj -0.035 Tc 9.7344 0 0 10.6 407.5 358.33 Tm (th)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 414.61 358.33 Tm [(e )-72(s)]TJ 0.243 0.247 0.235 rg -0.035 Tc 10.4248 0 0 10.6 427.17 358.33 Tm (tomach )Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 460.19 358.33 Tm (\()Tj 0.243 0.247 0.235 rg -0.035 Tc 10.0797 0 0 10.6 463.57 358.33 Tm (from )Tj 0.4 0.4 0.392 rg 10.05 0 0 10.6 486.58 358.33 Tm (sw)Tj 0.243 0.247 0.235 rg 9.957 0 0 10.6 497.66 358.33 Tm (all)Tj 0.4 0.4 0.392 rg 10.355 0 0 10.6 507.26 358.33 Tm (owed )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 7.0238 0 0 7 297.52 350.16 Tm (99)Tj -0.035 Tc 8.7494 0 0 10.6 305.26 347.28 Tm (mTc)Tj 0.243 0.247 0.235 rg 0 Tc 10.6 0 0 10.6 321.01 347.28 Tm (0)Tj 5.9001 0 0 5.9001 327.82 343.93 Tm (4)Tj 0.05 Tc 9.3796 0 0 5.9001 331.62 347.28 Tm (\), )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.4626 0 0 10.6 341.18 347.28 Tm (only )Tj 9.0854 0 0 10.6 363.34 347.28 Tm (th)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 370.45 347.28 Tm (e )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.4426 0 0 10.6 379.19 347.28 Tm (right )Tj 0.161 0.161 0.153 rg 10.472 0 0 10.6 401.67 347.28 Tm (lun)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 414.15 347.28 Tm (g )Tj 0.243 0.247 0.235 rg -0.023 Tc 0.814 0 Td (data )Tj 0 Tc 2 0 Td (w)Tj 0.4 0.4 0.392 rg 0.625 0 Td (e)Tj 0.243 0.247 0.235 rg 0.507 0 Td (r)Tj 0.4 0.4 0.392 rg 0.263 0 Td (e )Tj 0.243 0.247 0.235 rg -0.0286 Tc 0.77 0 Td (analy)Tj 0.4 0.4 0.392 rg -0.035 Tc 10.5734 0 0 10.6 488.97 347.28 Tm (se)Tj 0.243 0.247 0.235 rg 10.1983 0 0 10.6 497.18 347.28 Tm (d. )Tj 0.337 0.337 0.329 rg 10.2634 0 0 10.6 307.18 336.25 Tm (Also )Tj 0.243 0.247 0.235 rg 10.1513 0 0 10.6 329.28 336.25 Tm (usin)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 345.51 336.25 Tm (g )Tj 0.243 0.247 0.235 rg -0.035 Tc 9.0854 0 0 10.6 354.22 336.25 Tm (th)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 361.33 336.25 Tm (e )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.4648 0 0 10.6 369.62 336.25 Tm (perfusion )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /C0_0 1 Tf 0 Tc 5.76 0 0 8.64 409.93 336.25 Tm <007E0061006E0020>Tj EMC ET BT 0.161 0.161 0.153 rg /T1_0 1 Tf -0.035 Tc 9.5728 0 0 10.6 431.44 336.25 Tm (im)Tj 0.337 0.337 0.329 rg -0.0309 Tc 10.6 0 0 10.6 441.49 336.25 Tm (age )Tj 0.0478 Tc 1.631 0 Td (of )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 10.1134 0 0 10.6 471.03 336.25 Tm (!he )Tj EMC ET BT /T1_0 1 Tf 9.1875 0 0 10.6 486.71 336.25 Tm (ri)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 492.39 336.25 Tm (g)Tj 0.243 0.247 0.235 rg -0.035 Tc 10.4051 0 0 10.6 497.75 336.25 Tm (ht )Tj 9.6665 0 0 10.6 509.2 336.25 Tm (lun)Tj 0.4 0.4 0.392 rg 10.2814 0 0 10.6 520.71 336.25 Tm (g, )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0296 Tc 10.6 0 0 10.6 297.97 325.69 Tm (anolher )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.4518 0 0 10.6 331.22 325.69 Tm (programme )Tj 10.0572 0 0 10.6 380.15 325.69 Tm (was )Tj 0 Tc 10.6 0 0 10.6 399.36 325.69 Tm (u)Tj 0.4 0.4 0.392 rg -0.035 Tc 10.4791 0 0 10.6 403.53 325.69 Tm (sed )Tj 0.243 0.247 0.235 rg 9.7344 0 0 10.6 420.94 325.69 Tm (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0265 Tc 10.6 0 0 10.6 431.42 325.69 Tm (define )Tj EMC ET BT /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 459.7326 325.69 Tm (a )Tj 0.337 0.337 0.329 rg -0.035 Tc 9.7455 0 0 10.6 467.91 325.69 Tm (cen1ral )Tj 10.2207 0 0 10.6 498.14 325.69 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.0251 0 0 10.6 516.5 325.69 Tm (pe\255)Tj EMC ET BT 0.161 0.161 0.153 rg /T1_0 1 Tf 10.2081 0 0 10.6 298.07 314.65 Tm (riph)Tj 0.4 0.4 0.392 rg -0.0336 Tc 10.6 0 0 10.6 313.81 314.65 Tm (era)Tj 0.243 0.247 0.235 rg 0 Tc 1.179 0 Td (l )Tj -0.035 Tc 10.1404 0 0 10.6 332.55 314.65 Tm (lung )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 10.3967 0 0 10.6 353.22 314.65 Tm (zone. )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 378.7 314.65 Tm (A )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.4206 0 0 10.6 389.27 314.65 Tm (horizontal )Tj EMC ET BT /T1_0 1 Tf 10.4594 0 0 10.6 432.87 314.65 Tm (line )Tj 0.337 0.337 0.329 rg 10.3816 0 0 10.6 451.19 314.65 Tm (was )Tj -0.0194 Tc 10.6 0 0 10.6 469.81 314.65 Tm (exte)Tj 0.161 0.161 0.153 rg -0.035 Tc 9.4833 0 0 10.6 487.19 314.65 Tm (nd)Tj 0.337 0.337 0.329 rg 9.7271 0 0 10.6 496.7 314.65 Tm (ed )Tj 0.161 0.161 0.153 rg 8.8589 0 0 10.6 510.14 314.65 Tm (fr)Tj 0.337 0.337 0.329 rg 9.8232 0 0 10.6 515.91 314.65 Tm (om )Tj 0.161 0.161 0.153 rg 9.7344 0 0 10.6 298.54 304.09 Tm (th)Tj 0.337 0.337 0.329 rg 0 Tc 10.6 0 0 10.6 305.65 304.09 Tm (e )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.0572 0 0 10.6 315.34 304.09 Tm (mid)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 330.6 304.09 Tm (-)Tj 0.243 0.247 0.235 rg -0.0245 Tc 0.33 0 Td (point )Tj 0.337 0.337 0.329 rg 0.0478 Tc 2.343 0 Td (of )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.4562 0 0 10.6 372.45 304.09 Tm (the )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf -0.0216 Tc 10.6 0 0 10.6 389.26 304.09 Tm (vertica)Tj 0.161 0.161 0.153 rg 0 Tc 2.62 0 Td (l )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0277 Tc 10.6 0 0 10.6 424.3036 304.09 Tm (height )Tj 0.0478 Tc 2.755 0 Td (of )Tj -0.035 Tc 10.4562 0 0 10.6 467.01 304.09 Tm (the )Tj 0.078 0.078 0.071 rg 0 Tc 10.6 0 0 10.6 484.23 304.09 Tm (l)Tj 0.243 0.247 0.235 rg -0.035 Tc 10.0742 0 0 10.6 487.2 304.09 Tm (ung )Tj 9.7344 0 0 10.6 506.86 304.09 Tm (to )Tj 9.5456 0 0 10.6 519.28 304.09 Tm (it)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 524.01 304.09 Tm (s )Tj 0.243 0.247 0.235 rg -0.035 Tc 10.5929 0 0 10.6 298.06 293.05 Tm (medial )Tj 10.3353 0 0 10.6 329.29 293.05 Tm (bord)Tj 0.4 0.4 0.392 rg 0 Tc 10.6 0 0 10.6 347.41 293.05 Tm (e)Tj 0.243 0.247 0.235 rg 0.461 0 Td (r)Tj 0.4 0.4 0.392 rg 0.348 0 Td (, )Tj 0.337 0.337 0.329 rg -0.035 Tc 10.2207 0 0 10.6 361.34 293.05 Tm (and )Tj 0.243 0.247 0.235 rg 10.0797 0 0 10.6 380.05 293.05 Tm (from )Tj -0.0274 Tc 10.6 0 0 10.6 403.17 293.05 Tm (this )Tj -0.0131 Tc 1.725 0 Td (point )Tj -0.035 Tc 10.5388 0 0 10.6 446.31 293.05 Tm (lines )Tj 0 Tc 10.6 0 0 10.6 468.94 293.05 Tm (w)Tj 0.4 0.4 0.392 rg 0.625 0 Td (e)Tj 0.243 0.247 0.235 rg 0.461 0 Td (r)Tj 0.4 0.4 0.392 rg 0.308 0 Td (e )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0336 Tc 10.6 0 0 10.6 491.889 293.05 Tm (drawn )Tj EMC /Suspect <>BDC 0 Tc 8.1 0 0 8.1 521.21 293.05 Tm (l)Tj 0.4 0.4 0.392 rg 0.295 0 Td (O )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf -0.0118 Tc 7.8001 0 0 7.8001 298.05 141.37 Tm (Fig)Tj 0.506 0.506 0.494 rg 0 Tc 1.337 0 Td (. )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf 7.8001 0 0 7.8001 314.3522 141.37 Tm (I)Tj 0.4 0.4 0.392 rg 0.417 0 Td (. )Tj EMC /Suspect <>BDC 0.337 0.337 0.329 rg 0.624 0 Td (-)Tj EMC ET BT /T1_0 1 Tf 0.007 Tc 7.8001 0 0 7.8001 330.2332 141.37 Tm (Aerosol )Tj 0.243 0.247 0.235 rg 0.0094 Tc 3.686 0 Td (image)Tj 0.4 0.4 0.392 rg 0 Tc 2.394 0 Td (s )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 0.0214 Tc 7.8001 0 0 7.8001 384.4205 141.37 Tm (oblained )Tj EMC ET BT /T1_0 1 Tf -0.0224 Tc 7.8001 0 0 7.8001 415.6287 141.37 Tm (in )Tj 0.4 0.4 0.392 rg 0 Tc 1.168 0 Td (o)Tj 0.243 0.247 0.235 rg 0.562 0 Td (n)Tj 0.4 0.4 0.392 rg 0.483 0 Td (e )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf 0.0131 Tc 7.8001 0 0 7.8001 439.6842 141.37 Tm (normal )Tj EMC ET BT 0.4 0.4 0.392 rg /T1_0 1 Tf 0 Tc 7.8001 0 0 7.8001 465.9862 141.37 Tm (s)Tj 0.243 0.247 0.235 rg 0.008 Tc 0.383 0 Td (ubj)Tj 0.4 0.4 0.392 rg 0.05 Tc 8.1078 0 0 7.8001 478.95 141.37 Tm (ect )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0044 Tc 7.8001 0 0 7.8001 491.91 141.37 Tm (\(lefl )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf 0.0061 Tc 7.8001 0 0 7.8001 508.3292 141.37 Tm (panel; )Tj ET BT /Suspect <>BDC 0.4 0.4 0.392 rg /T1_0 1 Tf 0.0204 Tc 7.8001 0 0 7.8001 298.0463 132.2517 Tm (FE)Tj 0.243 0.247 0.235 rg 0 Tc 1.232 0 Td (V )Tj EMC ET BT 0.4 0.4 0.392 rg /T1_1 1 Tf 5.2 0 0 5.2 313.28 128.89 Tm (1 )Tj 0.337 0.337 0.329 rg /T1_0 1 Tf -0.002 Tc 7.8001 0 0 7.8001 320.13 132.25 Tm (4.3 )Tj 0.4 0.4 0.392 rg /T1_2 1 Tf 0.0128 Tc 7.4001 0 0 7.4001 333.98 132.25 Tm (f\) )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0225 Tc 7.8001 0 0 7.8001 342.64 132.25 Tm (and )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 7.8813 0 0 7.8001 358.01 132.25 Tm (one )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 0.0154 Tc 7.8001 0 0 7.8001 373.84 132.25 Tm (asthmatic )Tj EMC /Suspect <>BDC 0.4 0.4 0.392 rg -0.0143 Tc 4.427 0 Td (subject. )Tj EMC ET BT /T1_0 1 Tf 0.0176 Tc 7.8001 0 0 7.8001 435.2736 132.25 Tm (\(rig)Tj 0.243 0.247 0.235 rg 0.05 Tc 8.1643 0 0 7.8001 446.87 132.25 Tm (ht )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 0.0061 Tc 7.8001 0 0 7.8001 457.45 132.25 Tm (panel; )Tj EMC /Suspect <>BDC -0.0124 Tc 3.072 0 Td (FEV )Tj EMC ET BT 0.4 0.4 0.392 rg /T1_1 1 Tf 0 Tc 5.2 0 0 5.2 497.12 129.37 Tm (1 )Tj 0.243 0.247 0.235 rg /T1_0 1 Tf 7.8001 0 0 7.8001 504.21 132.25 Tm (1)Tj 0.4 0.4 0.392 rg 0.0117 Tc 0.383 0 Td (.55 )Tj 0.337 0.337 0.329 rg /T1_1 1 Tf -0.0182 Tc 7.4001 0 0 7.4001 521.25 132.25 Tm (t\). )Tj /T1_0 1 Tf 0.0232 Tc 7.8001 0 0 7.8001 297.53 123.12 Tm (These )Tj 0.0036 Tc 2.894 0 Td (images )Tj 0.029 Tc 3.206 0 Td (have )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0104 Tc 7.8001 0 0 7.8001 363.3706 123.12 Tm (been )Tj EMC ET BT 0.4 0.4 0.392 rg /T1_0 1 Tf 0.0097 Tc 7.8001 0 0 7.8001 381.0145 123.12 Tm (subdivide)Tj 0.243 0.247 0.235 rg 0 Tc 4.005 0 Td (d )Tj 0.337 0.337 0.329 rg 0.0228 Tc 0.92 0 Td (for )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0123 Tc 7.8001 0 0 7.8001 431.4421 123.12 Tm (each )Tj EMC ET BT /T1_0 1 Tf 0.0076 Tc 7.8001 0 0 7.8001 449.2185 123.12 Tm (lung )Tj 0.0207 Tc 2.154 0 Td (into )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf 0.0247 Tc 7.8001 0 0 7.8001 481.4174 123.12 Tm (three )Tj EMC /Suspect <>BDC 0.4 0.4 0.392 rg -0.0159 Tc 2.4 0 Td (t.ones )Tj EMC /Suspect <>BDC 0.337 0.337 0.329 rg -0.035 Tc 7.3288 0 0 7.8001 521.21 123.12 Tm (as )Tj EMC ET BT /T1_0 1 Tf 0.0149 Tc 7.8001 0 0 7.8001 297.53 114.48 Tm (described )Tj -0.035 Tc 7.2743 0 0 7.8001 333.06 114.48 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0066 Tc 7.8001 0 0 7.8001 343.18 114.48 Tm (the )Tj EMC /Suspect <>BDC 0.0108 Tc 1.786 0 Td (methods )Tj EMC ET BT 0.4 0.4 0.392 rg /T1_0 1 Tf 0.0121 Tc 7.8001 0 0 7.8001 388.21 114.48 Tm (section. )Tj 0.337 0.337 0.329 rg 0.0317 Tc 3.759 0 Td (The )Tj 0.0031 Tc 2.153 0 Td (aerosol )Tj ET BT /Suspect <>BDC 0.4 0.4 0.392 rg /T1_0 1 Tf 0.05 Tc 7.8327 0 0 7.8001 461.17 114.48 Tm (scan )Tj EMC ET BT /T1_0 1 Tf 8.3469 0 0 7.8001 480.4 114.48 Tm (of )Tj 0.337 0.337 0.329 rg 0.0066 Tc 7.8001 0 0 7.8001 491.5 114.48 Tm (the )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf 0 Tc 7.8001 0 0 7.8001 504.9474 114.48 Tm (n)Tj 0.4 0.4 0.392 rg 0.0226 Tc 0.485 0 Td (ormal )Tj EMC /Suspect <>BDC 0 Tc -27.082 -1.169 Td (s)Tj 0.243 0.247 0.235 rg 0.0468 Tc 0.383 0 Td (ub)Tj 0.4 0.4 0.392 rg 0.05 Tc 7.9921 0 0 7.8001 307.87 105.36 Tm (jec)Tj 0.243 0.247 0.235 rg 0 Tc 7.8001 0 0 7.8001 318.22 105.36 Tm (t )Tj EMC /Suspect <>BDC 0.337 0.337 0.329 rg 0.0121 Tc 0.542 0 Td (shows )Tj EMC ET BT /T1_0 1 Tf 0 Tc 7.8001 0 0 7.8001 344.5609 105.36 Tm (a )Tj 0.243 0.247 0.235 rg 0.747 0 Td (r)Tj 0.4 0.4 0.392 rg 0.299 0 Td (e)Tj 0.243 0.247 0.235 rg 0.495 0 Td (l)Tj 0.4 0.4 0.392 rg -0.0314 Tc 0.305 0 Td (ati)Tj 0.243 0.247 0.235 rg 0 Tc 0.994 0 Td (v)Tj 0.4 0.4 0.392 rg 0.483 0 Td (e)Tj 0.243 0.247 0.235 rg -0.0233 Tc 0.495 0 Td (ly )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 0.007 Tc 7.8001 0 0 7.8001 382.563 105.36 Tm (uniform )Tj EMC ET BT /T1_0 1 Tf 0.0128 Tc 7.8001 0 0 7.8001 410.3314 105.36 Tm (distribution )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0044 Tc 7.8001 0 0 7.8001 449.7531 105.36 Tm (with )Tj EMC /Suspect <>BDC 0 Tc 2.083 0 Td (a )Tj EMC /Suspect <>BDC 0.007 Tc 0.75 0 Td (penetration )Tj EMC /Suspect <>BDC 0.4 0.4 0.392 rg -0.032 Tc 4.914 0 Td (indel! )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_0 1 Tf 0.0213 Tc 7.8001 0 0 7.8001 297.5107 96.2495 Tm (\(PI\) )Tj 0.05 Tc 8.3469 0 0 7.8001 312.88 96.25 Tm (of )Tj ET BT /Suspect <>BDC 0.243 0.247 0.235 rg /T1_0 1 Tf -0.035 Tc 7.8188 0 0 8.1 323.73 96.25 Tm (1.1; )Tj EMC ET BT 0.337 0.337 0.329 rg /T1_1 1 Tf 8.1964 0 0 8.2 337.76 96.25 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0373 Tc 7.8001 0 0 7.8001 347.02 96.25 Tm (the )Tj EMC /Suspect <>BDC 0.0308 Tc 1.592 0 Td (asthmatic )Tj EMC /Suspect <>BDC 0.4 0.4 0.392 rg 0.0121 Tc 4.365 0 Td (subject. )Tj EMC /Suspect <>BDC 0.337 0.337 0.329 rg 0.0093 Tc 3.581 0 Td (there )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf -0.0345 Tc 7.8001 0 0 7.8001 440.5744 96.25 Tm (is )Tj 0 Tc 1.044 0 Td (a )Tj ET BT /Suspect <>BDC 0.337 0.337 0.329 rg /T1_0 1 Tf 0.0107 Tc 7.8001 0 0 7.8001 455.0514 96.25 Tm (patchy )Tj EMC /Suspect <>BDC 0.4 0.4 0.392 rg 0.0104 Tc 3.128 0 Td (centm)Tj 0.243 0.247 0.235 rg 0 Tc 2.524 0 Td (l )Tj EMC /Suspect <>BDC 0.337 0.337 0.329 rg 0.0092 Tc 0.614 0 Td (deposi)Tj 0.506 0.506 0.494 rg 0 Tc 2.705 0 Td (\255)Tj EMC /Suspect <>BDC 0.337 0.337 0.329 rg -0.0044 Tc -29.16 -1.171 Td (tion )Tj EMC /Suspect <>BDC 0.0044 Tc 2.032 0 Td (with )Tj EMC /Suspect <>BDC -0.0121 Tc 2.274 0 Td (PI )Tj EMC /Suspect <>BDC 0.4 0.4 0.392 rg 0.0131 Tc 1.286 0 Td (0.51. )Tj EMC /Suspect <>BDC 0.337 0.337 0.329 rg 0.0184 Tc 2.529 0 Td (FEV)Tj /T1_1 1 Tf 0 Tc 5.2 0 0 5.2 376.16 83.76 Tm (1)Tj 0.558 0.646 Td (: )Tj EMC ET BT 0.243 0.247 0.235 rg /T1_0 1 Tf 7.8001 0 0 7.8001 384.87 87.12 Tm (f)Tj 0.4 0.4 0.392 rg 0.0196 Tc 0.249 0 Td (orced )Tj 0.337 0.337 0.329 rg 0.0246 Tc 2.706 0 Td (expiratory )Tj 0.0171 Tc 4.747 0 Td (volume )Tj -0.0224 Tc 3.501 0 Td (in )Tj ET BT /Suspect <>BDC 0.4 0.4 0.392 rg /T1_0 1 Tf 0.05 Tc 7.8813 0 0 7.8001 481.37 87.12 Tm (one )Tj EMC /Suspect <>BDC 0.506 0.506 0.494 rg 0 Tc 7.8001 0 0 7.8001 496.21 87.12 Tm (s)Tj 0.4 0.4 0.392 rg 0.373 0 Td (e)Tj 0.506 0.506 0.494 rg 0.05 Tc 7.8936 0 0 7.8001 502.96 87.12 Tm (co)Tj 0.337 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0.0345 Tc 1.188 0 Td (the )Tj 0.0231 Tc 1.676 0 Td (lung )Tj 0.0276 Tc 2.175 0 Td (edge, )Tj 0.0204 Tc 2.574 0 Td (defining )Tj 0.0345 Tc 3.867 0 Td (the )Tj 0.0351 Tc 2.023 0 Td (inner )Tj 0.0245 Tc 2.483 0 Td (border )Tj 0.05 Tc 10.5727 0 0 9.7 279.26 689.05 Tm (of )Tj 0.0097 Tc 9.7 0 0 9.7 58.06 678 Tm (the )Tj 0.0185 Tc 1.834 0 Td (peripheral )Tj 0.013 Tc 4.843 0 Td (zone. )Tj 0.0388 Tc 2.818 0 Td (These )Tj 0.0231 Tc 3.118 0 Td (lung )Tj 0.0201 Tc 2.424 0 Td (contours )Tj 0.0473 Tc 4.165 0 Td (were )Tj 0.0048 Tc 2.671 0 Td (then )Tj 0.0195 Tc -21.885 -1.137 Td (superimposed )Tj 0.0101 Tc 6.191 0 Td (on )Tj 0.0097 Tc 1.541 0 Td (the )Tj 0.0187 Tc 1.732 0 Td (two )Tj 0.0241 Tc 1.971 0 Td (aerosol )Tj 0.0263 Tc 3.464 0 Td (and )Tj 0.0156 Tc 1.941 0 Td (background )Tj 0.0074 Tc 5.385 0 Td (im\255)Tj 0.0388 Tc -22.27 -1.139 Td (ages )Tj 0.0205 Tc 2.277 0 Td (obtained )Tj 0.026 Tc 4.006 0 Td (for )Tj 0.0237 Tc 1.634 0 Td (each )Tj 0.0276 Tc 2.322 0 Td (subject )Tj 0.0021 Tc 3.368 0 Td (\(fig. )Tj 0.09 0.09 0.086 rg -0.0193 Tc 2.253 0 Td (1\) )Tj 0.176 0.176 0.173 rg -0.0186 Tc 1.214 0 Td (in )Tj 0.0346 Tc 1.187 0 Td (order )Tj 0.0171 Tc 2.63 0 Td (to )Tj 0.0029 Tc 1.23 0 Td (cal\255)Tj 0.0054 Tc -22.12 -1.089 Td (culate: )Tj 0.0268 Tc 3.166 0 Td (a\) )Tj 0.0208 Tc 1.535 0 Td (central )Tj 0.0347 Tc 3.221 0 Td (zone )Tj 0.0113 Tc 2.322 0 Td (deposition )Tj 0.0203 Tc 4.7 0 Td (as )Tj 0 Tc 1.237 0 Td (a )Tj 0.006 Tc 0.84 0 Td (fraction )Tj 0.05 Tc 10.5727 0 0 9.7 257.18 645.36 Tm (of )Tj 0.0066 Tc 9.7 0 0 9.7 269.68 645.36 Tm (lung )Tj 0.007 Tc -21.873 -1.137 Td (dose; )Tj 0.0263 Tc 2.671 0 Td (and )Tj -0.0316 Tc 1.991 0 Td (b\) )Tj 0.013 Tc 1.732 0 Td (peripheral )Tj 0.0182 Tc 4.645 0 Td (zone )Tj 0.0113 Tc 2.421 0 Td (deposition )Tj 0.05 Tc 9.9203 0 0 9.7 234.14 634.33 Tm (as )Tj 0 Tc 9.7 0 0 9.7 246.62 634.33 Tm (a )Tj 0.006 Tc 0.939 0 Td (fraction )Tj 0.05 Tc 10.5727 0 0 9.7 57.5 623.29 Tm (of )Tj 0.0231 Tc 9.7 0 0 9.7 70.48 623.29 Tm (lung )Tj 0.0137 Tc 2.325 0 Td (dose. )Tj 0 Tc 2.679 0 Td (A )Tj 0.0118 Tc 1.191 0 Td (penetration )Tj 0.0181 Tc 5.137 0 Td (index )Tj 0.0158 Tc 2.768 0 Td (\(PI\) )Tj 0.0135 Tc 2.031 0 Td (defined )Tj 0.0203 Tc 3.562 0 Td (as )Tj 0.0345 Tc 1.344 0 Td (the )Tj 0.025 Tc -22.366 -1.089 Td (ratio )Tj 0.05 Tc 10.5727 0 0 9.7 80.06 612.73 Tm (of )Tj -0.015 Tc 9.7 0 0 9.7 93.58 612.73 Tm (the )Tj 0.0185 Tc 1.636 0 Td (peripheral )Tj 0.0182 Tc 4.695 0 Td (zone )Tj 0 Tc 2.371 0 Td (d)Tj 0.282 0.282 0.275 rg 0.543 0 Td (e)Tj 0.176 0.176 0.173 rg 0.0149 Tc 0.407 0 Td (position )Tj 0.05 Tc 9.8951 0 0 9.7 224.14 612.73 Tm (to )Tj 0.0208 Tc 9.7 0 0 9.7 236.07 612.73 Tm (central )Tj 0.0347 Tc 3.27 0 Td (zone )Tj 0.017 Tc -21.67 -1.139 Td (was )Tj 0.0048 Tc 1.978 0 Td (then )Tj 0.0112 Tc 2.17 0 Td (derived. )Tj 0.0082 Tc -3.209 -1.137 Td (All )Tj 0.0118 Tc 1.831 0 Td (measurements )Tj 0.05 Tc 10.5727 0 0 9.7 145.82 590.65 Tm (of )Tj 0.0166 Tc 9.7 0 0 9.7 158.87 590.65 Tm (radioactivity )Tj -0.0186 Tc 5.782 0 Td (in )Tj 0.0345 Tc 1.293 0 Td (the )Tj 0.0231 Tc 1.775 0 Td (lung )Tj 0.0143 Tc 2.333 0 Td (were )Tj 0.0206 Tc -21.682 -1.138 Td (corrected )Tj 0.026 Tc 4.303 0 Td (for )Tj 0.0156 Tc 1.695 0 Td (background )Tj 0.0192 Tc 5.284 0 Td (activity )Tj 0.0263 Tc 3.563 0 Td (and )Tj 0.0144 Tc 1.939 0 Td (radioisotope )Tj 0.0098 Tc 5.534 0 Td (de\255)Tj 0.0222 Tc -22.318 -1.089 Td (cay. )Tj 0.05 Tc 10.0747 0 0 9.7 77.73 569.05 Tm (We )Tj 0.0159 Tc 9.7 0 0 9.7 96.47 569.05 Tm (have )Tj 0.0163 Tc 2.376 0 Td (used )Tj -0.015 Tc 2.373 0 Td (the )Tj 0.0117 Tc 2.081 0 Td (perfusion )Tj 0.0106 Tc 4.339 0 Td (scan )Tj 0.0171 Tc 2.289 0 Td [(to )-149(allow )]TJ -0.035 Tc 9.5618 0 0 9.7 265.92 569.05 Tm (us )Tj 0.0171 Tc 9.7 0 0 9.7 278.86 569.05 Tm (to )Tj 0.09 0.09 0.086 rg 0.0319 Tc -22.91 -1.139 Td (relate )Tj 0.176 0.176 0.173 rg 0.0239 Tc 2.811 0 Td (emitted )Tj 0.0166 Tc 3.613 0 Td (counts )Tj 0.0057 Tc 3.165 0 Td (from )Tj 0.0345 Tc 2.483 0 Td (the )Tj 0.0045 Tc 2.276 0 Td (thorax )Tj 0.0171 Tc 3.118 0 Td (to )Tj 0.0097 Tc 1.287 0 Td (the )Tj 0.0191 Tc 1.725 0 Td (dose )Tj 0.05 Tc 10.5727 0 0 9.7 277.82 558 Tm (of )Tj 0.0097 Tc 9.7 0 0 9.7 57.1 546.97 Tm (the )Tj 0.0248 Tc 1.775 0 Td (isotope )Tj 0.0132 Tc 3.464 0 Td (inhaled. )Tj 0.0482 Tc 3.81 0 Td (The )Tj 0.0191 Tc 2.127 0 Td (dose )Tj 0.05 Tc 10.5727 0 0 9.7 188.54 546.97 Tm (of )Tj 0.0174 Tc 9.7 0 0 9.7 202 546.97 Tm (injected )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0 Tc 6.8001 0 0 6.8001 238.51 550.33 Tm (9)Tj -0.035 Tc 9.6134 0 0 10.3 241.84 546.97 Tm (9m'J'c-MAA )Tj EMC ET BT /T1_0 1 Tf 0.017 Tc 9.7 0 0 9.7 57.11 536.41 Tm (was )Tj 0.0128 Tc 2.168 0 Td (accurately )Tj 0.0249 Tc 4.808 0 Td (known )Tj 0.05 Tc 9.7132 0 0 9.7 157.34 536.41 Tm (and )Tj 9.9129 0 0 9.7 177.59 536.41 Tm (we )Tj 0.0304 Tc 9.7 0 0 9.7 194.3 536.41 Tm (assumed )Tj 0.0131 Tc 4.214 0 Td (that )Tj 0.0019 Tc 2.07 0 Td (all )Tj 0.017 Tc 1.593 0 Td (was )Tj 0.0124 Tc -22.022 -1.139 Td (trapped )Tj 0.0049 Tc 3.514 0 Td (within )Tj 0.0097 Tc 3.018 0 Td (the )Tj 0.0066 Tc 1.627 0 Td (lung )Tj 0.0094 Tc 2.233 0 Td (microvasculature. )Tj 0 Tc 7.769 0 Td (A )Tj 0.0105 Tc 1.081 0 Td (calibration )Tj 0.0252 Tc -19.301 -1.137 Td (factor )Tj 0.0417 Tc 2.979 0 Td (was )Tj 0.0218 Tc 2.12 0 Td (derived )Tj 0.0171 Tc 3.62 0 Td (to )Tj 0.0215 Tc 1.279 0 Td (defme )Tj 0.0097 Tc 3.125 0 Td (the )Tj 0.0167 Tc 1.733 0 Td (relationship )Tj 0.016 Tc 5.396 0 Td (between )Tj 0.0245 Tc -20.248 -1.09 Td (injected )Tj 0.0166 Tc 3.917 0 Td (radioactivity )Tj 0.05 Tc 9.7132 0 0 9.7 151.1 503.76 Tm (and )Tj 0.0239 Tc 9.7 0 0 9.7 171.74 503.76 Tm (emitted )Tj 0.0265 Tc 3.712 0 Td (counts )Tj 0.0106 Tc 3.363 0 Td (\(calibration )Tj 0.0152 Tc -18.953 -1.138 Td (factor=injected )Tj 0.0356 Tc 6.781 0 Td (dose )Tj 0.0134 Tc 2.373 0 Td (\(mCi\)/total )Tj 0.0231 Tc 5.051 0 Td (lung )Tj 0.0134 Tc 2.325 0 Td (counts\), )Tj 0.0199 Tc 4.205 0 Td (assum\255)Tj 0.0376 Tc -20.732 -1.089 Td (ing )Tj 0.0296 Tc 2.184 0 Td (that )Tj 0 Tc 1.922 0 Td (a )Tj 0.0286 Tc 0.936 0 Td (similar )Tj 0.0122 Tc 3.279 0 Td (relationship )Tj 0.024 Tc 5.236 0 Td (exists )Tj 0.016 Tc 3.228 0 Td (between )Tj 0.0075 Tc 3.9 0 Td (inhaled )Tj 0.0191 Tc -20.686 -1.138 Td (dose )Tj 0.0263 Tc 2.523 0 Td (and )Tj 0.0156 Tc 2.078 0 Td (emitted )Tj 0.0134 Tc 3.663 0 Td (counts. )Tj 0.0482 Tc 3.564 0 Td (The )Tj 0.0154 Tc 2.226 0 Td (calibration )Tj 0.0054 Tc 5.045 0 Td (factor )Tj 0.017 Tc 2.979 0 Td (was )Tj 0.0328 Tc -22.069 -1.089 Td (used )Tj 0.09 0.09 0.086 rg 0.05 Tc 9.8951 0 0 9.7 79.18 460.56 Tm (to )Tj 0.176 0.176 0.173 rg 0.0232 Tc 9.7 0 0 9.7 91.11 460.56 Tm (calculate )Tj 0.0345 Tc 4.164 0 Td (the )Tj 0.0232 Tc 1.683 0 Td (right )Tj 0.0396 Tc 2.368 0 Td (lung )Tj 0.0159 Tc 2.274 0 Td (aerosol )Tj 0.0356 Tc 3.415 0 Td (dose )Tj 0.05 Tc 9.9203 0 0 9.7 248.54 460.56 Tm (as )Tj 0 Tc 9.7 0 0 9.7 261.02 460.56 Tm (a )Tj 0.011 Tc 0.902 0 Td (per\255)Tj 0.023 Tc -21.981 -1.137 Td (centage )Tj 0.05 Tc 11.1292 0 0 9.7 91.09 449.53 Tm (of )Tj 0.0345 Tc 9.7 0 0 9.7 104.62 449.53 Tm (the )Tj 0.0356 Tc 1.675 0 Td (dose )Tj 0.0191 Tc 2.326 0 Td (delivered )Tj 0.0488 Tc 4.315 0 Td (by )Tj 0.0097 Tc 1.531 0 Td (the )Tj 0.0184 Tc 2.129 0 Td (nebulizer )Tj 0.05 Tc 10.1194 0 0 9.7 261.98 449.53 Tm (at )Tj 0.0345 Tc 9.7 0 0 9.7 274.06 449.53 Tm (the )Tj 0.0042 Tc -22.416 -1.089 Td (mouth. )Tj 0.0261 Tc 0.889 -1.138 Td (Based )Tj 0.05 Tc 9.7902 0 0 9.7 93.51 427.93 Tm (on )Tj 0 Tc 9.7 0 0 9.7 107.9 427.93 Tm (a )Tj 0.0024 Tc 0.899 0 Td (total )Tj 0.0356 Tc 2.17 0 Td (dose )Tj 0.05 Tc 10.5727 0 0 9.7 160.22 427.93 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0291 Tc 9.7 0 0 9.7 172.22 427.93 Tm (0.5 )Tj EMC ET BT /T1_0 1 Tf 0.0329 Tc 9.7 0 0 9.7 188.6227 427.93 Tm (mCi )Tj 0.05 Tc 10.5727 0 0 9.7 209.66 427.93 Tm (of )Tj 0 Tc 6.4001 0 0 6.4001 222.17 430.81 Tm (9)Tj -0.0332 Tc 9.7 0 0 9.7 225.01 427.93 Tm (9mTc0)Tj 0 Tc 6.4001 0 0 6.4001 250.54 424.56 Tm (4 )Tj 0.05 Tc 9.7132 0 0 9.7 257.18 427.93 Tm (and )Tj 0.0101 Tc 9.7 0 0 9.7 275.91 427.93 Tm (on )Tj 0.05 Tc 9.7766 0 0 9.7 56.06 417.37 Tm (an )Tj 0.0204 Tc 9.7 0 0 9.7 70.48 417.37 Tm (intravenous )Tj 0.05 Tc 9.7314 0 0 9.7 121.83 417.37 Tm (dose )Tj 10.5727 0 0 9.7 145.34 417.37 Tm (of )Tj -0.0202 Tc 9.7 0 0 9.7 159.02 417.37 Tm (1.5 )Tj 0.0329 Tc 1.666 0 Td (mCi )Tj 0.05 Tc 10.5727 0 0 9.7 197.18 417.37 Tm (of )Tj /T1_1 1 Tf 0 Tc 7.1 0 0 7.1 214.02 419.76 Tm (9)Tj -0.029 Tc 10.3 0 0 10.3 216.88 417.37 Tm (9mTc-MAA, )Tj /T1_0 1 Tf 0.0097 Tc 9.7 0 0 9.7 274.06 417.37 Tm (the )Tj 0.0266 Tc -22.466 -1.189 Td (maximum )Tj 0.0212 Tc 4.605 0 Td (possible )Tj 0.0247 Tc 4.195 0 Td (exposure )Tj -0.0324 Tc 4.61 0 Td (to )Tj 0.014 Tc 1.535 0 Td (radiation )Tj 0.05 Tc 9.8318 0 0 9.7 240.5 405.84 Tm (per )Tj 0.0276 Tc 9.7 0 0 9.7 257.62 405.84 Tm (subject )Tj 0.017 Tc -20.77 -1.089 Td (was )Tj 0.0067 Tc 1.97 0 Td (estimated )Tj 0.0171 Tc 4.264 0 Td (to )Tj 0.05 Tc 9.7621 0 0 9.7 127.69 395.28 Tm (be )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0355 Tc 9.7 0 0 9.7 141.01 395.28 Tm (350 )Tj EMC ET BT /T1_0 1 Tf 0.0099 Tc 9.7 0 0 9.7 159.343 395.28 Tm (mrad )Tj 0.0171 Tc 2.474 0 Td (to )Tj 0.0097 Tc 1.138 0 Td (the )Tj 0.0066 Tc 1.577 0 Td (lungs )Tj 0.0263 Tc 2.571 0 Td (and )Tj -0.035 Tc 9.6688 0 0 9.7 253.11 395.28 Tm (15 )Tj 0.0264 Tc 9.7 0 0 9.7 265.9 395.28 Tm (mrad )Tj 0.05 Tc 9.8951 0 0 9.7 56.14 384.25 Tm (to )Tj 0.0097 Tc 9.7 0 0 9.7 68.14 384.25 Tm (the )Tj 0.0092 Tc 1.684 0 Td (whole )Tj 0.0293 Tc 2.823 0 Td (body )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.012 Tc 9.7 0 0 9.7 136.5735 384.25 Tm ([11, )Tj EMC ET BT /T1_0 1 Tf -0.009 Tc 9.7 0 0 9.7 156.1481 384.25 Tm (12]. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 7.6 0 0 7.6 72.87 320.89 Tm (3)Tj 0.577 0.577 0.569 rg 0.496 0 Td (.)Tj 0.282 0.282 0.275 rg 0.05 Tc 11.7164 0 0 7.6 79.56 320.89 Tm (0, )Tj EMC /Suspect <>BDC /T1_2 1 Tf 0 Tc 15.6 0 0 15.6 87.53 306.97 Tm (i )Tj EMC ET BT 0.577 0.577 0.569 rg /T1_2 1 Tf 53.6 0 0 53.6 231.85 279.12 Tm (/ )Tj ET BT /Suspect <>BDC 0.176 0.176 0.173 rg /T1_2 1 Tf 14 0 0 14 87.45 296.41 Tm (I )Tj EMC /Suspect <>BDC 0.282 0.282 0.275 rg /T1_0 1 Tf 7.6 0 0 7.6 72.44 293.05 Tm (2)Tj 0.577 0.577 0.569 rg 0.616 0 Td (.)Tj 0.176 0.176 0.173 rg 0.387 0 Td (5)Tj 0.416 0.416 0.412 rg -0.035 Tc 6.4123 0 0 7.6 85.37 293.05 Tm (-, )Tj EMC /Suspect <>BDC 0 Tc 4.7 0 0 4.7 205.39 293.53 Tm (0 )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg 0.05 Tc 8.2629 0 0 5.1 58.51 284.89 Tm (\)\( )Tj EMC ET BT 0.282 0.282 0.275 rg /T1_2 1 Tf 0 Tc 14.6 0 0 14.6 87.55 280.09 Tm (i )Tj ET BT /Suspect <>BDC 0.176 0.176 0.173 rg /T1_0 1 Tf 0.05 Tc 5.3184 0 0 5.1 58.51 279.61 Tm (Q\) )Tj EMC /Suspect <>BDC /T1_2 1 Tf 6.9939 0 0 6.6 56.55 272.89 Tm ("C )Tj EMC /Suspect <>BDC 0.09 0.09 0.086 rg /T1_0 1 Tf -0.035 Tc 8.6624 0 0 9.8 58.48 267.12 Tm (c: )Tj EMC /Suspect <>BDC 0.577 0.577 0.569 rg 0.0074 Tc 7.8001 0 0 7.8001 72.43 264.72 Tm (2.)Tj 0.416 0.416 0.412 rg 0 Tc 0.919 0 Td (0 )Tj EMC /Suspect <>BDC 0.09 0.09 0.086 rg -0.035 Tc 9.3843 0 0 9.8 57.99 254.65 Tm (c: )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg 0.0311 Tc 10.4 0 0 10.4 56.42 246.01 Tm (.2 )Tj EMC /Suspect <>BDC 0.82 0.82 0.816 rg 0 Tc 4.7 0 0 4.7 270.19 249.85 Tm (0 )Tj EMC ET BT 0.176 0.176 0.173 rg /T1_2 1 Tf 30.8 0 0 30.8 56.83 235.44 Tm (-)Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.5096 0 0 9.8 58.01 237.37 Tm (ca )Tj EMC /Suspect <>BDC 0.09 0.09 0.086 rg /T1_2 1 Tf 8.1396 0 0 16 57.86 233.52 Tm (... )Tj EMC /Suspect <>BDC 0.282 0.282 0.275 rg /T1_0 1 Tf 0.0273 Tc 6.8001 0 0 6.8001 73.21 237.37 Tm (1.)Tj 0.416 0.416 0.412 rg 0 Tc 1.009 0 Td (5 )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg /T1_2 1 Tf 11.2 0 0 11.2 161.59 233.05 Tm (\225 )Tj EMC ET BT /T1_2 1 Tf 30.8 0 0 30.8 56.83 223.44 Tm (-)Tj ET BT /Suspect <>BDC 0.282 0.282 0.275 rg /T1_0 1 Tf 4.4001 0 0 4.4001 159.8 228.25 Tm (0 )Tj EMC /Suspect <>BDC 0.577 0.577 0.569 rg /T1_2 1 Tf -0.035 Tc 3.9366 0 0 6.7 171.78 225.85 Tm (<> )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg /T1_0 1 Tf 0.05 Tc 5.7616 0 0 5.1 58.02 225.85 Tm (Q\) )Tj EMC /Suspect <>BDC 0.416 0.416 0.412 rg 0 Tc 4.7 0 0 4.7 153.55 223.93 Tm (0 )Tj EMC /Suspect <>BDC 0.749 0.749 0.745 rg /T1_2 1 Tf 11.9 0 0 11.9 205.28 216.73 Tm (" )Tj EMC /Suspect <>BDC 0.09 0.09 0.086 rg /T1_0 1 Tf -0.035 Tc 8.6624 0 0 9.8 58 219.13 Tm (c: )Tj EMC /Suspect <>BDC 0.82 0.82 0.816 rg 0 Tc 4.8001 0 0 4.8001 226.51 217.69 Tm (0 )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg /T1_2 1 Tf -0.035 Tc 5.3885 0 0 6.3001 58 213.37 Tm (Cll )Tj EMC /Suspect <>BDC 0.416 0.416 0.412 rg /T1_0 1 Tf 0 Tc 12.2 0 0 12.2 175.93 210.01 Tm (" )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg -0.0063 Tc 10.8 0 0 10.8 56.53 207.61 Tm (c. )Tj EMC ET BT 0.416 0.416 0.412 rg /T1_0 1 Tf 0 Tc 7.1 0 0 7.1 72.72 209.52 Tm (1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 7.1 0 0 7.1 79.607 209.52 Tm (0 )Tj EMC /Suspect <>BDC 0.577 0.577 0.569 rg 4.4001 0 0 4.4001 161.24 210.97 Tm (0 )Tj EMC /Suspect <>BDC 0.416 0.416 0.412 rg 4.8001 0 0 4.8001 170.83 209.05 Tm (0 )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg /T1_2 1 Tf 17.4 0 0 17.4 102.5 186.01 Tm (' )Tj EMC /Suspect <>BDC 0.416 0.416 0.412 rg /T1_0 1 Tf 4.8001 0 0 4.8001 170.35 197.52 Tm (0 )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg 0.0295 Tc 7.6 0 0 7.6 72.4 182.16 Tm (0.)Tj 0.282 0.282 0.275 rg 0 Tc 0.945 0 Td (5 )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg /T1_2 1 Tf 11.2 0 0 11.2 107.83 181.69 Tm (\225 )Tj EMC /Suspect <>BDC 1.5 -0.857 Td (\225 )Tj EMC /Suspect <>BDC 0.282 0.282 0.275 rg /T1_0 1 Tf 7.6 0 0 7.6 224.15 175.93 Tm (r)Tj 0.416 0.416 0.412 rg 0.438 0 Td (=)Tj 0.282 0.282 0.275 rg 0.05 Tc 7.9217 0 0 7.6 231.28 175.93 Tm (0.69 )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg 0 Tc 7.6 0 0 7.6 224.17 164.41 Tm (p)Tj 0.282 0.282 0.275 rg 0.562 0 Td (<)Tj 0.176 0.176 0.173 rg 0.0271 Tc 0.5 0 Td (0.001 )Tj EMC /Suspect <>BDC 0 Tc -19.832 -2.147 Td (0 )Tj EMC /Suspect <>BDC 0.05 Tc 8.3108 0 0 7.6 110.31 148.57 Tm (0.5 )Tj EMC /Suspect <>BDC 0 Tc 7.6 0 0 7.6 137.02 148.57 Tm (1)Tj 0.282 0.282 0.275 rg 0.582 0 Td (.)Tj 0.176 0.176 0.173 rg 0.326 0 Td (0 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.2591 0 0 7.6 166.27 148.57 Tm (1.5 )Tj ET BT /Suspect <>BDC 0.282 0.282 0.275 rg /T1_0 1 Tf 7.9333 0 0 7.6 191.95 148.57 Tm (2.0 )Tj EMC ET BT /T1_0 1 Tf 7.9333 0 0 7.6 217.8681 148.57 Tm (2.5 )Tj ET BT /Suspect <>BDC 0.176 0.176 0.173 rg /T1_0 1 Tf 0.0448 Tc 7.6 0 0 7.6 243.75 148.57 Tm (3.)Tj 0.282 0.282 0.275 rg 0 Tc 1.012 0 Td (0 )Tj EMC ET BT 0.176 0.176 0.173 rg /T1_0 1 Tf 0.0448 Tc 7.6 0 0 7.6 272.554 148.57 Tm (3.)Tj 0.282 0.282 0.275 rg 0 Tc 0.946 0 Td (5 )Tj 0.176 0.176 0.173 rg /T1_2 1 Tf 0.0307 Tc 9.9 0 0 9.9 111.71 135.13 Tm (Specific )Tj 0.0309 Tc 4.172 0 Td (conductance )Tj ET BT /Suspect <>BDC 0.09 0.09 0.086 rg /T1_2 1 Tf 0.0098 Tc 9.9 0 0 9.9 215.9174 135.13 Tm (s\267'\267kPa\267' )Tj EMC ET BT 0.176 0.176 0.173 rg /T1_0 1 Tf -0.0061 Tc 8.1 0 0 8.1 54.21 115.93 Tm (Fig)Tj 0.282 0.282 0.275 rg 0 Tc 1.346 0 Td (. )Tj 0.176 0.176 0.173 rg 0.489 0 Td (2)Tj 0.282 0.282 0.275 rg 0.578 0 Td (. )Tj 0.09 0.09 0.086 rg 0.0473 Tc 0.484 0 Td (-Relationship )Tj 0.176 0.176 0.173 rg -0.0099 Tc 6.235 0 Td (between )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.002 Tc 8.1 0 0 8.1 156.9828 115.93 Tm (penetration )Tj EMC ET BT /T1_0 1 Tf -0.0028 Tc 8.1 0 0 8.1 195.7818 115.93 Tm (index )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0049 Tc 8.1 0 0 8.1 215.9346 115.93 Tm (and )Tj EMC ET BT /T1_0 1 Tf -0.0004 Tc 8.1 0 0 8.1 230.4255 115.93 Tm (baseline )Tj 0.0002 Tc 3.541 0 Td (specific )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0006 Tc 8.1 0 0 8.1 54.1776 106.8013 Tm (conductance )Tj EMC ET BT /T1_0 1 Tf 0.0296 Tc 8.1 0 0 8.1 96.8889 106.8013 Tm (for )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0263 Tc 8.1 0 0 8.1 108.9255 106.8013 Tm (20 )Tj EMC ET BT /T1_0 1 Tf -0.0049 Tc 8.1 0 0 8.1 119.4555 106.8013 Tm (aerosol )Tj -0.0054 Tc 3.196 0 Td (studi)Tj 0.282 0.282 0.275 rg 0 Tc 1.899 0 Td (e)Tj 0.176 0.176 0.173 rg 0.472 0 Td (s )Tj 0.0131 Tc 0.667 0 Td (perfonned )Tj 0.0278 Tc 4.374 0 Td (on )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0196 Tc 8.1 0 0 8.1 216.7041 106.8013 Tm (10 )Tj EMC ET BT /T1_0 1 Tf 0.0137 Tc 8.1 0 0 8.1 227.0559 106.8013 Tm (nonnal )Tj 0 Tc 3.427 0 Td (\( )Tj ET BT /Suspect <>BDC 0.282 0.282 0.275 rg /T1_2 1 Tf 7.7 0 0 7.7 258.15 106.8 Tm (0)Tj 0.176 0.176 0.173 rg 1.179 0 Td (\) )Tj EMC ET BT /T1_0 1 Tf 0.0248 Tc 8.1 0 0 8.1 272.08 106.8 Tm (and )Tj 0 Tc -26.965 -1.126 Td (6 )Tj -0.0028 Tc 1.01 0 Td (asthmatic )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.05 Tc 12.6228 0 0 7.7 96.26 97.68 Tm (\(e\) )Tj EMC ET BT /T1_0 1 Tf 0.001 Tc 8.1 0 0 8.1 116.05 97.68 Tm (subjects)Tj 0.282 0.282 0.275 rg 0 Tc 3.252 0 Td (. )Tj 0.176 0.176 0.173 rg -0.0004 Tc 1.138 0.059 Td (There )Tj 0.002 Tc 2.726 0 Td (is )Tj 0 Tc 1.125 0 Td (a )Tj -0.0043 Tc 0.885 0 Td (significant )Tj 0.0107 Tc 4.568 0 Td (linear )Tj -0.0039 Tc 2.725 0 Td (correlation )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0296 Tc 8.4 0 0 8.4 54.14 88.57 Tm (\(r-:0.69)Tj 0.282 0.282 0.275 rg 0 Tc 2.849 0 Td (; )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg -0.035 Tc 7.7602 0 0 8.4 83.53 88.57 Tm (p>BDC /T1_0 1 Tf -0.0124 Tc 9.7 0 0 9.7 510.7042 719.29 Tm (mouth\255)Tj EMC ET BT /T1_0 1 Tf 0.0325 Tc 9.7 0 0 9.7 308.1779 708.7267 Tm (piece )Tj 0.017 Tc 2.571 0 Td (was )Tj 0.016 Tc 1.922 0 Td (connected )Tj 0.0171 Tc 4.56 0 Td (to )Tj 0 Tc 1.13 0 Td [(a )-153(4 )]TJ 0.0369 Tc 1.732 0 Td (em )Tj 0.0183 Tc 1.683 0 Td (diameter )Tj 0.05 Tc 9.7132 0 0 9.7 477.98 708.73 Tm (and )Tj 0 Tc 9.7 0 0 9.7 496.15 708.73 Tm (8 )Tj 0.0369 Tc 0.898 0 Td (em )Tj 0.0066 Tc 1.635 0 Td (long )Tj 0.0043 Tc -21.863 -1.139 Td (plastic )Tj 0.0213 Tc 3.114 0 Td (tube )Tj 0.0118 Tc 2.214 0 Td (stuffed )Tj 0.0033 Tc 3.329 0 Td (with )Tj 0.0226 Tc 2.263 0 Td (sponge )Tj 0.0185 Tc 3.368 0 Td (foam )Tj -0.0186 Tc 2.626 0 Td (in )Tj 0.0346 Tc 1.236 0 Td (order )Tj 0.0171 Tc 2.63 0 Td (to )Tj 0.011 Tc 1.237 0 Td (trap )Tj -0.0009 Tc -22.029 -1.137 Td (aerosol. )Tj 0 Tc 3.72 0 Td (A )Tj 0.0103 Tc 1.28 0 Td (liter )Tj 0.017 Tc 2.122 0 Td [(syringe )-246(was )]TJ 0.0213 Tc 5.645 0 Td (attached )Tj 0.0333 Tc 4.008 0 Td (at )Tj 0.0067 Tc 1.289 0 Td (its )Tj 0.0238 Tc 1.434 0 Td (other )Tj 0.0059 Tc 2.622 0 Td (end )Tj 0.0263 Tc -22.169 -1.138 Td (and )Tj 0.0097 Tc 1.938 0 Td (the )Tj 0.0205 Tc 1.636 0 Td (plunger )Tj 0.017 Tc 3.511 0 Td (was )Tj 0.014 Tc 2.028 0 Td (manually )Tj 0.021 Tc 4.199 0 Td (drawn )Tj 0.05 Tc 10.1194 0 0 9.7 465.98 675.61 Tm (at )Tj 0 Tc 9.7 0 0 9.7 477.5 675.61 Tm (a )Tj 0.0151 Tc 0.842 0 Td (constant )Tj 0.0128 Tc 3.819 0 Td (rate )Tj 0.026 Tc -22.08 -1.089 Td (for )Tj 0 Tc 1.589 0 Td (2 )Tj 0.05 Tc 10.1243 0 0 9.7 332.5 665.05 Tm (s, )Tj 0.0225 Tc 9.7 0 0 9.7 342.63 665.05 Tm (causing )Tj 0.0097 Tc 3.62 0 Td (the )Tj 0.0184 Tc 1.634 0 Td (nebulizer )Tj 0.05 Tc 9.8951 0 0 9.7 434.86 665.05 Tm (to )Tj 0.0184 Tc 9.7 0 0 9.7 446.86 665.05 Tm (trigger )Tj 0.0012 Tc 3.207 0 Td (for )Tj 0.0291 Tc 1.585 0 Td (0.6 )Tj -0.0199 Tc 1.678 0 Td (s. )Tj 0.024 Tc 1 0 Td (Five )Tj 0.0081 Tc -21.734 -1.139 Td (such )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0112 Tc 9.7 0 0 9.7 333.4185 654.0017 Tm ("inhalations" )Tj EMC ET BT /T1_0 1 Tf 0.0308 Tc 9.7 0 0 9.7 391.667 654.0017 Tm (were )Tj 0.039 Tc 2.625 0 Td (perfonned )Tj 0.026 Tc 5.035 0 Td (for )Tj 0.0237 Tc 1.881 0 Td (each )Tj 0.0127 Tc 2.569 0 Td (sponge )Tj -0.0115 Tc -20.681 -1.089 Td (foam. )Tj 0.0238 Tc 2.824 0 Td (This )Tj -0.0078 Tc 2.382 0 Td (was )Tj 0.0188 Tc 2.029 0 Td (repeated )Tj 0.0289 Tc 3.998 0 Td (\(n=7\) )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0198 Tc 9.7 0 0 9.7 444.9491 643.4384 Tm (with )Tj EMC ET BT /T1_0 1 Tf 0.0029 Tc 9.7 0 0 9.7 467.8896 643.4384 Tm (fresh )Tj 0.0142 Tc 2.582 0 Td (tubing )Tj 0.0263 Tc 3.06 0 Td (and )Tj 0.0226 Tc -22.124 -1.137 Td (sponge )Tj 0.0021 Tc 3.467 0 Td (foam )Tj 0.05 Tc 10.1194 0 0 9.7 367.58 632.41 Tm (at )Tj 0.0304 Tc 9.7 0 0 9.7 380.03 632.41 Tm (5-min )Tj 0.0175 Tc 3.024 0 Td (intervals )Tj 0.05 Tc 9.7132 0 0 9.7 449.18 632.41 Tm (and )Tj 0.0345 Tc 9.7 0 0 9.7 469.42 632.41 Tm (the )Tj 0.09 0.09 0.086 rg 0.0124 Tc 1.782 0 Td (radioactivity )Tj 0.176 0.176 0.173 rg -0.0108 Tc -18.419 -1.089 Td (from )Tj 0.0345 Tc 2.335 0 Td (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0246 Tc 9.7 0 0 9.7 345.9584 621.8467 Tm (99""fc0)Tj 0 Tc 5.9001 0 0 5.9001 373.9 618.48 Tm (4 )Tj EMC ET BT /T1_0 1 Tf 0.0124 Tc 9.7 0 0 9.7 380.62 621.85 Tm (trapped )Tj -0.0186 Tc 3.408 0 Td (in )Tj 0.0345 Tc 1.144 0 Td (the )Tj 0.0226 Tc 1.571 0 Td (sponge )Tj 0.0417 Tc 3.279 0 Td (was )Tj 0.0176 Tc 1.922 0 Td (detennined. )Tj /T1_1 1 Tf 0.0035 Tc 10 0 0 10 307.66 590.65 Tm (Statistics )Tj /T1_0 1 Tf 0.0329 Tc 9.7 0 0 9.7 316.78 569.05 Tm (All )Tj 0.0152 Tc 2.474 0 Td (values )Tj 0.0159 Tc 3.811 0 Td (have )Tj 0.0178 Tc 3.07 0 Td (been )Tj 0.0234 Tc 2.512 0 Td (expressed )Tj 0.05 Tc 9.9203 0 0 9.7 477.02 569.05 Tm (as )Tj -0.0303 Tc 9.7 0 0 9.7 491.5 569.05 Tm (mean\261sEM. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0107 Tc 9.7 0 0 9.7 307.976 558.0017 Tm (Statistical )Tj EMC ET BT /T1_0 1 Tf 0.018 Tc 9.7 0 0 9.7 356.0201 558.0017 Tm (significance )Tj 0.017 Tc 5.457 0 Td (was )Tj 0.0172 Tc 2.069 0 Td (expressed )Tj 0.0154 Tc 4.563 0 Td (using )Tj 0.0238 Tc 2.703 0 Td (Student')Tj 0.282 0.282 0.275 rg 0 Tc 3.419 0 Td (s )Tj 0.176 0.176 0.173 rg -0.0028 Tc -23.146 -1.089 Td (t-test. )Tj 0.0073 Tc 2.769 0 Td (Regression )Tj 0.0155 Tc 5.041 0 Td (analysis )Tj 0.0417 Tc 3.82 0 Td (was )Tj 0.02 Tc 2.12 0 Td (calculated )Tj 0.0488 Tc 4.662 0 Td (by )Tj 0.0097 Tc 1.58 0 Td (the )Tj 0.0167 Tc 1.726 0 Td (least )Tj 0.016 Tc -21.779 -1.137 Td (squares )Tj 0.0039 Tc 3.674 0 Td (method. )Tj 0.05 Tc 9.7388 0 0 9.7 380.61 536.41 Tm (We )Tj 0.0188 Tc 9.7 0 0 9.7 399.26 536.41 Tm (accepted )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0231 Tc 9.7 0 0 9.7 439.6896 536.41 Tm (p<0.05 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.9203 0 0 9.7 473.66 536.41 Tm (as )Tj 0.0089 Tc 9.7 0 0 9.7 487.6 536.41 Tm (indicating )Tj 0 Tc 4.6 0 Td (a )Tj 0.0164 Tc -23.163 -1.139 Td (significant )Tj 0.0115 Tc 4.706 0 Td (difference. )Tj 0.0171 Tc 10.1 0 0 10.1 406.99 495.12 Tm (Results )Tj /T1_1 1 Tf 0.0023 Tc 10 0 0 10 307.27 464.89 Tm (Baseline )Tj 0.0058 Tc 3.826 0 Td (aerosol )Tj -0.015 Tc 3.404 0 Td (lung )Tj 0.01 Tc 2.126 0 Td (scans )Tj /T1_0 1 Tf 0.0263 Tc 9.7 0 0 9.7 316.24 442.81 Tm (Twenty )Tj 0.0217 Tc 3.622 0 Td (baseline )Tj 0.022 Tc 3.894 0 Td (scans )Tj 0.0308 Tc 2.735 0 Td (were )Tj 0.0278 Tc 2.465 0 Td (examined )Tj 0.0082 Tc 4.552 0 Td (\(eleven )Tj -0.035 Tc 9.5628 0 0 9.7 518.29 442.81 Tm (from )Tj 0.0307 Tc 9.7 0 0 9.7 307.19 432.25 Tm (nonnal )Tj 0.0105 Tc 3.352 0 Td (subjects )Tj 0.0263 Tc 3.666 0 Td (and )Tj 0.0216 Tc 1.89 0 Td (nine )Tj 0.0057 Tc 2.167 0 Td (from )Tj 0.018 Tc 2.376 0 Td (asthmatic )Tj 0.0093 Tc 4.4 0 Td (subjects\). )Tj 0.0235 Tc 4.262 0 Td (The )Tj 0.016 Tc -22.11 -1.138 Td (proportion )Tj 0.05 Tc 10.0163 0 0 9.7 355.1 421.21 Tm (of )Tj 0.0161 Tc 9.7 0 0 9.7 368.63 421.21 Tm (nebulized )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 6.4001 0 0 6.4001 413.21 424.09 Tm (9)Tj -0.035 Tc 8.2906 0 0 9.7 416.07 421.21 Tm (9mTc )Tj EMC ET BT /T1_0 1 Tf 0.0168 Tc 9.7 0 0 9.7 440.07 421.21 Tm (depositing )Tj -0.0186 Tc 4.9 0 Td (in )Tj 0.0097 Tc 1.342 0 Td (the )Tj 0.0108 Tc 1.832 0 Td (right )Tj 0.0231 Tc -21.78 -1.139 Td (lung )Tj 0.034 Tc 2.176 0 Td (did )Tj 0.0312 Tc 1.691 0 Td (not )Tj 0.0232 Tc 1.674 0 Td (differ )Tj 0.0025 Tc 2.667 0 Td (significantly )Tj 0.016 Tc 5.409 0 Td (between )Tj 0.0097 Tc 3.807 0 Td (the )Tj -0.0061 Tc 1.682 0 Td (two )Tj -0.007 Tc 1.874 0 Td (groups )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 11.0128 0 0 13.4 327.79 386.65 Tm (+60 )Tj EMC /Suspect <>BDC 0 Tc 8.5 0 0 8.5 443.91 372.72 Tm (0 )Tj EMC /Suspect <>BDC -0.035 Tc 11.3367 0 0 13.4 327.78 345.37 Tm (+40 )Tj EMC /Suspect <>BDC /C0_0 1 Tf 0 Tc 7.2 0 0 5.76 313.93 322.33 Tm <007E0020>Tj EMC /Suspect <>BDC /T1_0 1 Tf 9.1 0 0 9.1 443.91 321.37 Tm (0 )Tj EMC /Suspect <>BDC 4.8001 0 0 4.8001 313.87 320.41 Tm (0 )Tj EMC /Suspect <>BDC /C0_0 1 Tf 6.72 0 0 12 379.68 309.84 Tm <007E0020>Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 5.3184 0 0 5.1 315.31 308.89 Tm (Q\) )Tj EMC /Suspect <>BDC -0.035 Tc 11.3367 0 0 13.4 327.3 304.09 Tm (+20 )Tj EMC /Suspect <>BDC 0 Tc 6.1 0 0 6.1 314.82 302.65 Tm (0 )Tj EMC /Suspect <>BDC 0.09 0.09 0.086 rg /T1_2 1 Tf 21.5 0 0 21.5 379.82 296.89 Tm (\225 )Tj EMC ET BT /T1_0 1 Tf 7.1 0 0 7.1 314.81 296.89 Tm (0 )Tj ET BT /Suspect <>BDC 0.176 0.176 0.173 rg /T1_2 1 Tf 20.1 0 0 20.1 312.94 294 Tm (, )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 7.4752 0 0 5.1 314.8 282.97 Tm (C\) )Tj EMC ET BT /T1_0 1 Tf 0 Tc 18.1 0 0 18.1 377.5 275.28 Tm (s )Tj /T1_2 1 Tf 10.8 0 0 10.8 440.4 275.28 Tm (M )Tj /T1_0 1 Tf 18.1 0 0 18.1 508.62 275.28 Tm (c )Tj ET BT /Suspect <>BDC 0.09 0.09 0.086 rg /T1_0 1 Tf -0.035 Tc 7.9406 0 0 9.8 314.8 276.72 Tm (c: )Tj EMC /Suspect <>BDC 8.6022 0 0 15.8 312.86 262.81 Tm (-= )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg 0 Tc 13.4 0 0 13.4 337.3 260.89 Tm (0 )Tj EMC ET BT /T1_0 1 Tf 36.8 0 0 36.8 313 254.16 Tm (-)Tj ET BT /Suspect <>BDC 0.09 0.09 0.086 rg /T1_3 1 Tf -0.035 Tc 7.1151 0 0 8.3 312.36 255.61 Tm (.r:. )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg /T1_0 1 Tf 0 Tc 9.1 0 0 9.1 443.91 250.33 Tm (0 )Tj EMC /Suspect <>BDC 0.05 Tc 7.4752 0 0 5.1 313.84 250.8 Tm (C\) )Tj EMC /Suspect <>BDC 0 Tc 19.7001 0 0 19.7001 510.4 241.21 Tm (\225 )Tj EMC /Suspect <>BDC -0.035 Tc 10.837 0 0 11.3 312.25 244.09 Tm (\267.: )Tj EMC /Suspect <>BDC /T1_2 1 Tf 0 Tc 20.6 0 0 20.6 444.64 232.57 Tm (\225 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 8.8 0 0 8.8 509.67 237.37 Tm (0 )Tj EMC /Suspect <>BDC 0 g -0.0151 Tc 10.4 0 0 10.4 311.78 231.61 Tm (.5 )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg 0.05 Tc 5.3184 0 0 5.1 313.39 223.44 Tm (Q\) )Tj EMC /Suspect <>BDC -0.035 Tc 12.3971 0 0 13.4 327.21 217.21 Tm (-20 )Tj EMC /Suspect <>BDC 0.05 Tc 7.008 0 0 5.1 313.37 217.69 Tm (C\) )Tj EMC /Suspect <>BDC 0 Tc 20.8 0 0 20.8 445.58 211.44 Tm (\225 )Tj EMC /Suspect <>BDC 0.09 0.09 0.086 rg -0.035 Tc 7.9406 0 0 9.8 313.36 211.44 Tm (c: )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg /T1_2 1 Tf 0 Tc 21.5 0 0 21.5 380.3 207.61 Tm (\225 )Tj EMC /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 4.5691 0 0 6.4001 313.43 206.16 Tm (t1S )Tj EMC /Suspect <>BDC 0 Tc 20.8 0 0 20.8 380.3 199.93 Tm (\225 )Tj EMC /Suspect <>BDC 0.09 0.09 0.086 rg /T1_3 1 Tf -0.035 Tc 6.6407 0 0 8.3 311.89 200.41 Tm (.r:. )Tj EMC /Suspect <>BDC 0.176 0.176 0.173 rg /C0_0 1 Tf 0 Tc 12.48 0 0 12 377.77 191.29 Tm <007E0020>Tj EMC /Suspect <>BDC /T1_0 1 Tf 9.1 0 0 9.1 510.15 198.97 Tm (0 )Tj EMC ET BT /T1_2 1 Tf 8 0 0 8 311.43 193.69 Tm (0 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.1 0 0 9.1 444.87 192.73 Tm (0 )Tj EMC /Suspect <>BDC -0.035 Tc 12.0097 0 0 13.4 327.22 174.01 Tm (-40 )Tj EMC /Suspect <>BDC 0 Tc 9.1 0 0 9.1 510.15 170.65 Tm (0 )Tj EMC /Suspect <>BDC -14.242 -1.16 Td (0 )Tj EMC /Suspect <>BDC -0.035 Tc 12.3971 0 0 13.4 327.21 132.73 Tm (-60 )Tj EMC /Suspect <>BDC 0 Tc 9.1 0 0 9.1 444.87 128.41 Tm (0 )Tj EMC ET BT /T1_0 1 Tf -0.0281 Tc 8.1 0 0 8.1 306.21 114 Tm (Fig. )Tj 0 Tc 1.948 0 Td (3)Tj 0.282 0.282 0.275 rg 0.464 0 Td (. )Tj 0.09 0.09 0.086 rg 0.602 0 Td (-)Tj 0.176 0.176 0.173 rg 0.0102 Tc 0.89 0 Td (Change )Tj -0.035 Tc 7.9356 0 0 8.1 365.7 114 Tm (in )Tj 0.0053 Tc 8.1 0 0 8.1 374.81 114 Tm (lung )Tj 0.0047 Tc 2.132 0 Td (dose )Tj -0.035 Tc 7.9356 0 0 8.1 410.34 114 Tm (in )Tj 0.0134 Tc 8.1 0 0 8.1 419.5 114 Tm (the )Tj 0.0172 Tc 1.601 0 Td (right )Tj 0.0251 Tc 2.244 0 Td (lung )Tj -0.035 Tc 7.9356 0 0 8.1 468.42 114 Tm (in )Tj -0.0105 Tc 8.1 0 0 8.1 477.51 114 Tm (each )Tj -0.013 Tc 2.249 0 Td (subject )Tj 0 Tc 3.144 0 Td (a)Tj 0.282 0.282 0.275 rg 0.414 0 Td (f)Tj 0.176 0.176 0.173 rg 0.008 Tc 0.305 0 Td (ter )Tj -0.0035 Tc -27.27 -1.125 Td (salbutamol )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0103 Tc 8.1 0 0 8.1 344.5485 104.8875 Tm (\(S\), )Tj EMC ET BT /T1_0 1 Tf 0.0015 Tc 8.1 0 0 8.1 359.5011 104.8875 Tm (methacholine )Tj /T1_2 1 Tf 0.0443 Tc 7.7 0 0 7.7 406.91 104.89 Tm (\(M\) )Tj /T1_0 1 Tf -0.0049 Tc 8.1 0 0 8.1 422.8 104.89 Tm (and )Tj 0.0133 Tc 1.833 0 Td (saline )Tj 0.0204 Tc 7.8001 0 0 7.8001 460.23 104.89 Tm (\(C\) )Tj -0.035 Tc 7.9395 0 0 8.1 474.16 104.89 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4.02 0 Td (. )Tj 0.192 0.192 0.188 rg -0.035 Tc 10.4736 0 0 10.6 55.11 395.76 Tm (The )Tj 0.133 0.133 0.129 rg 10.4775 0 0 10.6 75.74 395.76 Tm (di)Tj 0.255 0.255 0.251 rg -0.0169 Tc 10.6 0 0 10.6 83.85 395.76 Tm (stributio)Tj 0.133 0.133 0.129 rg 0 Tc 3.183 0 Td (n )Tj 0.192 0.192 0.188 rg 0.0478 Tc 0.942 0 Td (of )Tj 0.133 0.133 0.129 rg -0.0269 Tc 1.314 0 Td (inhaled )Tj 0.192 0.192 0.188 rg -0.0337 Tc 3.258 0 Td (aerosol )Tj 0.133 0.133 0.129 rg -0.032 Tc 3.224 0 Td (with)Tj 0.255 0.255 0.251 rg 0.009 Tc 1.624 0 Td (in )Tj 0.133 0.133 0.129 rg -0.035 Tc 10.4562 0 0 10.6 241.41 395.76 Tm (the )Tj 10.4301 0 0 10.6 258.63 395.76 Tm (lung )Tj 0.255 0.255 0.251 rg -0.0218 Tc 10.6 0 0 10.6 45.97 384.72 Tm (appeared )Tj 0.192 0.192 0.188 rg -0.0309 Tc 3.814 0 Td (uniform )Tj -0.035 Tc 10.5807 0 0 10.6 122.79 384.72 Tm (in )Tj 0.133 0.133 0.129 rg -0.031 Tc 10.6 0 0 10.6 134.39 384.72 Tm (normal )Tj 0.192 0.192 0.188 rg -0.0228 Tc 3.066 0 Td (subjects, )Tj 0.0003 Tc 3.638 0 Td (but )Tj 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(amount )Tj 0.0478 Tc 3.307 0 Td (of )Tj -0.0186 Tc 1.176 0 Td (activity )Tj -0.035 Tc 9.9195 0 0 10.6 218.32 363.12 Tm (in )Tj 10.4562 0 0 10.6 230.85 363.12 Tm (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0342 Tc 10.6 0 0 10.6 247.22 363.12 Tm (periph\255)Tj EMC ET BT /T1_0 1 Tf 0.006 Tc 10.6 0 0 10.6 45.4914 352.0854 Tm (eral )Tj 0.255 0.255 0.251 rg -0.035 Tc 10.5748 0 0 10.6 65.22 352.09 Tm (zone )Tj 0.192 0.192 0.188 rg -0.0141 Tc 10.6 0 0 10.6 87.73 352.09 Tm (and )Tj 0 Tc 1.766 0 Td (a )Tj -0.0338 Tc 0.824 0 Td (more )Tj -0.0146 Tc 2.268 0 Td (patchy )Tj -0.0187 Tc 2.932 0 Td (distribution )Tj -0.035 Tc 9.9195 0 0 10.6 221.2 352.09 Tm (in )Tj 0.133 0.133 0.129 rg 10.3833 0 0 10.6 232.77 352.09 Tm (th)Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 240.37 352.09 Tm (e )Tj -0.0056 Tc 0.771 0 Td (ce)Tj 0.133 0.133 0.129 rg -0.0265 Tc 0.869 0 Td (ntral )Tj 0.255 0.255 0.251 rg -0.0213 Tc -20.02 -0.996 Td (zone )Tj 0.192 0.192 0.188 rg -0.0336 Tc 2.303 0 Td (\(fig. )Tj -0.0306 Tc 10.1 0 0 10.1 92.29 341.53 Tm (1\). )Tj 0.0293 Tc 1.503 0 Td (PI )Tj 0.255 0.255 0.251 rg -0.035 Tc 10.3816 0 0 10.6 121.43 341.53 Tm (was )Tj 0 Tc 10.6 0 0 10.6 141.93 341.53 Tm (s)Tj 0.133 0.133 0.129 rg -0.0178 Tc 0.368 0 Td (ignificantly )Tj -0.035 Tc 10.5252 0 0 10.6 197.19 341.53 Tm (low)Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 212.53 341.53 Tm (e)Tj 0.133 0.133 0.129 rg 0.416 0 Td (r )Tj 0.192 0.192 0.188 rg -0.035 Tc 9.9195 0 0 10.6 225.04 341.53 Tm (in )Tj -0.024 Tc 10.6 0 0 10.6 237.49 341.53 Tm (asthmatic )Tj 0.255 0.255 0.251 rg -0.0292 Tc -18.072 -1.042 Td (subjects )Tj ET BT /Suspect <>BDC 0.192 0.192 0.188 rg /T1_0 1 Tf -0.035 Tc 9.9406 0 0 10.6 82.44 330.49 Tm (\(p>BDC 0.192 0.192 0.188 rg /T1_0 1 Tf -0.022 Tc 10.6 0 0 10.6 255.8544 330.49 Tm (posi\255)Tj EMC ET BT /T1_0 1 Tf -0.0303 Tc 10.6 0 0 10.6 46.0486 319.4448 Tm (tive )Tj 0.255 0.255 0.251 rg -0.0212 Tc 1.714 0 Td (corre)Tj 0.133 0.133 0.129 rg -0.012 Tc 1.993 0 Td (lati)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.1631 0 0 10.6 98.3 319.44 Tm (on )Tj 0.192 0.192 0.188 rg -0.0248 Tc 10.6 0 0 10.6 111.85 319.44 Tm (between )Tj 0.0293 Tc 10.1 0 0 10.1 148.75 319.44 Tm (PI )Tj -0.035 Tc 10.5732 0 0 10.6 161.65 319.44 Tm (and )Tj -0.0197 Tc 10.6 0 0 10.6 180.49 319.44 Tm (baseline )Tj 0.255 0.255 0.251 rg 0 Tc 3.426 0 Td (s)Tj 0.133 0.133 0.129 rg 0.366 0 Td (G)Tj 0.255 0.255 0.251 rg -0.0219 Tc 0.679 0 Td (aw )Tj ET BT /Suspect <>BDC 0.192 0.192 0.188 rg /T1_0 1 Tf -0.0252 Tc 10.6 0 0 10.6 243.6978 319.44 Tm (\(r=0.69, )Tj EMC /Suspect <>BDC 0.133 0.133 0.129 rg 0 Tc -18.778 -1.041 Td (p)Tj 0.255 0.255 0.251 rg -0.035 Tc 9.9183 0 0 10.6 50.83 308.41 Tm (<0)Tj 0.012 0.016 0.012 rg 0 Tc 10.6 0 0 10.6 61.7 308.41 Tm (.)Tj 0.192 0.192 0.188 rg -0.035 Tc 10.4703 0 0 10.6 63.73 308.41 Tm (001; )Tj EMC ET BT /T1_0 1 Tf 10.1711 0 0 10.6 87.25 308.41 Tm (fig. )Tj -0.0113 Tc 10.6 0 0 10.6 106.02 308.41 Tm (2\), )Tj 0.133 0.133 0.129 rg -0.035 Tc 10.5732 0 0 10.6 122.29 308.41 Tm (and )Tj 0.192 0.192 0.188 rg -0.0323 Tc 10.6 0 0 10.6 142.57 308.41 Tm (between )Tj -0.0182 Tc 10.1 0 0 10.1 181.39 308.41 Tm (PI )Tj -0.035 Tc 10.5732 0 0 10.6 195.73 308.41 Tm (and )Tj 0.133 0.133 0.129 rg 10.3482 0 0 10.6 216.01 308.41 Tm (bas)Tj 0.255 0.255 0.251 rg -0.0159 Tc 10.6 0 0 10.6 228.85 308.41 Tm (eline )Tj 0.192 0.192 0.188 rg /T1_1 1 Tf 0.0033 Tc 9.8 0 0 9.8 253.68 308.41 Tm (FEY)Tj 0 Tc 5.5001 0 0 5.5001 272.95 305.05 Tm (1 )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf -0.0252 Tc 10.6 0 0 10.6 45.47 297.37 Tm (\(r=0.51, )Tj EMC /Suspect <>BDC 0.133 0.133 0.129 rg -0.0072 Tc 3.41 0 Td (p<0)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.4703 0 0 10.6 97.7 297.37 Tm (.05\). )Tj EMC ET BT 0.192 0.192 0.188 rg /T1_2 1 Tf -0.0033 Tc 10.1 0 0 10.1 45.19 269.53 Tm (Effects )Tj 0.255 0.255 0.251 rg 0.05 Tc 11.8974 0 0 10.1 76.22 269.53 Tm (of )Tj -0.005 Tc 10.1 0 0 10.1 88.24 269.53 Tm (changes )Tj 0 Tc 3.607 0 Td (i)Tj 0.133 0.133 0.129 rg 0.293 0 Td (n )Tj 0.192 0.192 0.188 rg 0.0076 Tc 0.853 0 Td (airway )Tj 0.255 0.255 0.251 rg -0.0088 Tc 3.183 0 Td (calib)Tj 0.133 0.133 0.129 rg 0 Tc 1.95 0 Td (r)Tj 0.255 0.255 0.251 rg 0.377 0 Td (e )Tj 0.192 0.192 0.188 rg -0.0227 Tc -14.547 -2.044 Td (i\) )Tj -0.0012 Tc 1.398 0 Td (Bronchodilatation. )Tj 0.255 0.255 0.251 rg /T1_0 1 Tf -0.0028 Tc 10.6 0 0 10.6 144.05 248.89 Tm (Ni)Tj 0.133 0.133 0.129 rg 0 Tc 1.036 0 Td (n)Tj 0.255 0.255 0.251 rg 0.443 0 Td (e )Tj -0.0186 Tc 0.811 0 Td (stud)Tj 0.133 0.133 0.129 rg 0 Tc 1.636 0 Td (i)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.4986 0 0 10.6 188.05 248.89 Tm (es )Tj 0.133 0.133 0.129 rg 0 Tc 10.6 0 0 10.6 201 248.89 Tm (f)Tj 0.255 0.255 0.251 rg -0.026 Tc 0.274 0 Td (ollowing )Tj ET BT /Suspect <>BDC 0.192 0.192 0.188 rg /T1_0 1 Tf -0.0212 Tc 10.6 0 0 10.6 243.6968 248.89 Tm (salbuta\255)Tj EMC ET BT 0.133 0.133 0.129 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 45.1058 237.8448 Tm (m)Tj 0.255 0.255 0.251 rg 0.717 0 Td (o)Tj 0.133 0.133 0.129 rg 0.454 0 Td (l )Tj 0.255 0.255 0.251 rg 0.78 0 Td (p)Tj 0.133 0.133 0.129 rg 0.494 0 Td (r)Tj 0.255 0.255 0.251 rg 0.308 0 Td (e)Tj 0.133 0.133 0.129 rg -0.0246 Tc 0.461 0 Td (medication )Tj 0.192 0.192 0.188 rg -0.0266 Tc 4.755 0 Td (were )Tj -0.0267 Tc 2.404 0 Td (performed )Tj -0.0273 Tc 4.514 0 Td (\(three )Tj -0.035 Tc 10.1631 0 0 10.6 231.26 237.85 Tm (on )Tj 0.133 0.133 0.129 rg -0.031 Tc 10.6 0 0 10.6 247.19 237.85 Tm (normal )Tj 0.192 0.192 0.188 rg -0.035 Tc 10.5844 0 0 10.6 44.97 226.8 Tm (subjects )Tj -0.0141 Tc 10.6 0 0 10.6 80.05 226.8 Tm (and )Tj 0.255 0.255 0.251 rg -0.035 Tc 10.3106 0 0 10.6 98.25 226.8 Tm (six )Tj 0.192 0.192 0.188 rg -0.0287 Tc 10.6 0 0 10.6 113.18 226.8 Tm (on )Tj -0.0297 Tc 1.267 0 Td (asthmatic )Tj -0.0321 Tc 3.936 0 Td (subjects\). )Tj -0.035 Tc 10.2249 0 0 10.6 209.23 226.8 Tm (Mean )Tj 10.2902 0 0 10.6 235.53 226.8 Tm (sGaw )Tj 10.2207 0 0 10.6 261.5 226.8 Tm (and )Tj 10.5184 0 0 10.6 45.1 216.25 Tm (mean )Tj /T1_1 1 Tf 0.0278 Tc 9.8 0 0 9.8 72.72 216.25 Tm (FEY )Tj 0 Tc 5.5001 0 0 5.5001 92.95 212.89 Tm (1 )Tj /T1_0 1 Tf -0.0165 Tc 10.6 0 0 10.6 101.67 216.25 Tm (increased )Tj -0.035 Tc 10.5967 0 0 10.6 146.28 216.25 Tm (from )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0222 Tc 10.6 0 0 10.6 172.21 216.25 Tm (0.84\2610.31 )Tj EMC ET BT 0.133 0.133 0.129 rg /T1_0 1 Tf -0.0048 Tc 10.6 0 0 10.6 219.8146 216.25 Tm (to )Tj 0 Tc 1.372 0 Td (1)Tj 0.255 0.255 0.251 rg -0.0156 Tc 0.422 0 Td (.46\2610.22 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.1232 0 0 10.6 44.99 205.69 Tm (s\267)Tj 0 Tc 6.2 0 0 6.2 50.67 208.57 Tm (1)Tj -0.035 Tc 8.5996 0 0 10.6 54.06 205.69 Tm (\2671cPa)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 71.3 205.69 Tm (\267)Tj 0.255 0.255 0.251 rg 6.2 0 0 6.2 73.71 208.57 Tm (1 )Tj EMC /Suspect <>BDC 0.192 0.192 0.188 rg -0.035 Tc 9.6481 0 0 10.6 82.45 205.69 Tm (\(p>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 174.6 205.69 Tm (3)Tj 0.133 0.133 0.129 rg -0.0282 Tc 0.489 0 Td (.0)Tj 0.255 0.255 0.251 rg -0.0124 Tc 0.649 0 Td (2\2610.46 )Tj EMC ET BT 0.133 0.133 0.129 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 221.2506 205.69 Tm (t)Tj 0.255 0.255 0.251 rg 0.22 0 Td (o )Tj ET BT /Suspect <>BDC 0.192 0.192 0.188 rg /T1_0 1 Tf -0.0259 Tc 10.6 0 0 10.6 234.6066 205.69 Tm (3.54\2610.38 )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_3 1 Tf 0 Tc 10.1 0 0 10.1 44.57 194.65 Tm (l )Tj /T1_0 1 Tf -0.035 Tc 8.0557 0 0 8.8 54.15 194.65 Tm (\(BTPS\) )Tj ET BT /Suspect <>BDC 0.192 0.192 0.188 rg /T1_0 1 Tf 10.123 0 0 10.6 80.52 194.65 Tm (\(p>BDC /T1_0 1 Tf -0.0335 Tc 10.6 0 0 10.6 177.01 129.37 Tm (0.73\2610.11 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.7344 0 0 10.6 222.7 129.37 Tm (to )Tj ET BT /Suspect <>BDC 0.133 0.133 0.129 rg /T1_0 1 Tf -0.0312 Tc 10.6 0 0 10.6 234.83 129.37 Tm (1.09)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.4892 0 0 10.6 251.99 129.37 Tm (\2610)Tj 0.012 0.016 0.012 rg 0 Tc 10.6 0 0 10.6 262.82 129.37 Tm (.)Tj 0.133 0.133 0.129 rg -0.035 Tc 9.6688 0 0 10.6 265.59 129.37 Tm (15 )Tj EMC /Suspect <>BDC 0.192 0.192 0.188 rg -0.027 Tc 10.6 0 0 10.6 44.03 118.32 Tm (\(p<0.05; )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.1711 0 0 10.6 82.93 118.32 Tm (fig. )Tj 10.5844 0 0 10.6 99.8 118.32 Tm (4\). )Tj 0.255 0.255 0.251 rg /T1_2 1 Tf -0.0073 Tc 10.1 0 0 10.1 44.03 94.32 Tm (ii\) )Tj 0.192 0.192 0.188 rg -0.0003 Tc 1.826 0 Td (Bronchoconstriclion. )Tj /T1_0 1 Tf 0.0015 Tc 10.6 0 0 10.6 158.31 94.32 Tm (The )Tj 0.255 0.255 0.251 rg -0.0067 Tc 1.991 0 Td (effect )Tj 0.192 0.192 0.188 rg 0.0478 Tc 2.673 0 Td (of )Tj 0.133 0.133 0.129 rg 0 Tc 1.275 0 Td (m)Tj 0.255 0.255 0.251 rg 0.716 0 Td (e)Tj 0.133 0.133 0.129 rg -0.035 Tc 10.4562 0 0 10.6 233.73 94.32 Tm (tha)Tj 0.255 0.255 0.251 rg -0.0322 Tc 10.6 0 0 10.6 245.66 94.32 Tm (cho)Tj 0.133 0.133 0.129 rg -0.035 Tc 9.9097 0 0 10.6 260.56 94.32 Tm (lin)Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 270.61 94.32 Tm (e )Tj 0.192 0.192 0.188 rg -0.0225 Tc -21.361 -0.996 Td (premedication )Tj -0.035 Tc 10.3816 0 0 10.6 106.07 83.76 Tm (was )Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 125.61 83.76 Tm (s)Tj 0.133 0.133 0.129 rg -0.035 Tc 9.7344 0 0 10.6 130.06 83.76 Tm (tu)Tj 0.255 0.255 0.251 rg -0.0269 Tc 10.6 0 0 10.6 137.66 83.76 Tm (died )Tj 0.192 0.192 0.188 rg -0.035 Tc 9.9195 0 0 10.6 159.28 83.76 Tm (in )Tj -0.026 Tc 10.6 0 0 10.6 171.24 83.76 Tm (five )Tj 0.133 0.133 0.129 rg 0 Tc 1.867 0 Td (n)Tj 0.255 0.255 0.251 rg -0.034 Tc 0.49 0 Td (ormal )Tj -0.0227 Tc 2.622 0 Td (subjects )Tj 0.192 0.192 0.188 rg -0.035 Tc 10.5732 0 0 10.6 260.53 83.76 Tm (and )Tj 0.255 0.255 0.251 rg 0.0254 Tc 7.6 0 0 7.6 298.05 494.65 Tm (Fig. )Tj 0 Tc 8.6 0 0 8.6 312.84 494.65 Tm (5)Tj 0.353 0.353 0.349 rg 0.05 Tc 14.6343 0 0 8.6 316.97 494.65 Tm (.-)Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf 0 Tc 7.6 0 0 7.6 327.33 494.65 Tm (R)Tj 0.353 0.353 0.349 rg 0.05 Tc 7.7218 0 0 7.6 332.56 494.65 Tm (ela)Tj 0.255 0.255 0.251 rg 0 Tc 7.6 0 0 7.6 342.22 494.65 Tm (t)Tj 0.353 0.353 0.349 rg 0.0185 Tc 0.311 0 Td (ions)Tj 0.255 0.255 0.251 rg 0 Tc 1.775 0 Td (h)Tj 0.353 0.353 0.349 rg 0.562 0 Td (i)Tj 0.255 0.255 0.251 rg 0.199 0 Td (p )Tj EMC ET BT 0.353 0.353 0.349 rg /T1_0 1 Tf 0.05 Tc 8.2978 0 0 7.6 370.09 494.65 Tm (be)Tj 0.255 0.255 0.251 rg 0.0139 Tc 7.6 0 0 7.6 378.22 494.65 Tm (tw)Tj 0.353 0.353 0.349 rg 0.0432 Tc 1.003 0 Td (een )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 7.65 0 0 7.6 399.34 494.65 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0433 Tc 7.6 0 0 7.6 411.29 494.65 Tm (cha)Tj 0.255 0.255 0.251 rg 0 Tc 1.524 0 Td (n)Tj 0.353 0.353 0.349 rg 0.05 Tc 7.8504 0 0 7.6 426.65 494.65 Tm (ge )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 7.6957 0 0 7.6 436.74 494.65 Tm (in )Tj EMC /Suspect <>BDC 0.255 0.255 0.251 rg 0.0093 Tc 7.6 0 0 7.6 445.45 494.65 Tm (pen)Tj 0.353 0.353 0.349 rg -0.0058 Tc 1.504 0 Td (elr8)Tj 0.255 0.255 0.251 rg 0 Tc 1.587 0 Td (t)Tj 0.353 0.353 0.349 rg 0.0012 Tc 0.311 0 Td (ion )Tj EMC /Suspect <>BDC 0.0175 Tc 1.642 0 Td (index )Tj EMC ET BT /T1_0 1 Tf 0.0103 Tc 7.6 0 0 7.6 503.9244 494.65 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0228 Tc 7.6 0 0 7.6 517.9008 494.65 Tm (the )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf 0.0243 Tc 7.6 0 0 7.6 298.01 485.53 Tm (chang)Tj 0.353 0.353 0.349 rg 0 Tc 2.525 0 Td (e )Tj -0.035 Tc 7.2743 0 0 7.6 324.42 485.53 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0202 Tc 7.6 0 0 7.6 333.49 485.53 Tm (specific )Tj EMC /Suspect <>BDC 0.0244 Tc 3.668 0 Td (co)Tj 0.255 0.255 0.251 rg 0 Tc 1.018 0 Td (n)Tj 0.353 0.353 0.349 rg 0.0299 Tc 0.497 0 Td (ducta)Tj 0.255 0.255 0.251 rg 0 Tc 2.282 0 Td (n)Tj 0.353 0.353 0.349 rg 0.0183 Tc 0.561 0 Td (ce )Tj EMC /Suspect <>BDC 0 Tc 1.328 0 Td (i)Tj 0.255 0.255 0.251 rg 0.322 0 Td (n)Tj 0.353 0.353 0.349 rg 0.0215 Tc 0.497 0 Td (duced )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf 0 Tc 7.6 0 0 7.6 433.4452 485.53 Tm (b)Tj 0.353 0.353 0.349 rg 0.503 0 Td (y )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0055 Tc 7.6 0 0 7.6 444.3968 485.53 Tm (ei)Tj 0.255 0.255 0.251 rg -0.0168 Tc 0.766 0 Td (th)Tj 0.353 0.353 0.349 rg 0 Tc 0.813 0 Td (e)Tj 0.255 0.255 0.251 rg 0.514 0 Td (r )Tj EMC /Suspect <>BDC 0.353 0.353 0.349 rg 0.745 0 Td (s)Tj 0.255 0.255 0.251 rg 0.05 Tc 8.222 0 0 7.6 468.88 485.53 Tm (al)Tj 0.353 0.353 0.349 rg 0.0341 Tc 7.6 0 0 7.6 475.21 485.53 Tm (butamo)Tj 0.255 0.255 0.251 rg 0 Tc 3.149 0 Td (l )Tj EMC ET BT 0.353 0.353 0.349 rg /T1_0 1 Tf 7.6 0 0 7.6 504.394 485.53 Tm (\( )Tj ET BT /Suspect <>BDC 0.133 0.133 0.129 rg /T1_0 1 Tf 7.6 0 0 7.6 508.2016 485.53 Tm (\225 )Tj EMC ET BT 0.51 0.51 0.506 rg /T1_1 1 Tf 9.9 0 0 9.9 515.43 485.53 Tm (o )Tj 0.353 0.353 0.349 rg -0.035 Tc 7.9136 0 0 9.9 522.58 485.53 Tm (\), )Tj 0.255 0.255 0.251 rg /T1_0 1 Tf 0.05 Tc 8.3469 0 0 7.6 298 475.93 Tm (or )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0476 Tc 7.6 0 0 7.6 307.19 475.93 Tm (me)Tj 0.353 0.353 0.349 rg 0.0099 Tc 1.325 0 Td (thacholi)Tj 0.255 0.255 0.251 rg 0 Tc 3.349 0 Td (n)Tj 0.353 0.353 0.349 rg 0.496 0 Td (e )Tj EMC /Suspect <>BDC 7.9001 0 0 7.9001 352.71 475.93 Tm (\()Tj 0.655 0.659 0.643 rg 0.05 Tc 8.8726 0 0 7.9001 355.98 475.93 Tm (.6 )Tj EMC /Suspect <>BDC 0.133 0.133 0.129 rg /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 366.25 475.93 Tm (A )Tj EMC ET BT 0.353 0.353 0.349 rg /T1_1 1 Tf 6.2 0 0 6.2 375.2524 475.93 Tm (\) )Tj /T1_0 1 Tf 0.05 Tc 8.3469 0 0 7.6 382.48 475.93 Tm (or )Tj 0.51 0.51 0.506 rg 0 Tc 7.6 0 0 7.6 391.57 475.93 Tm (s)Tj 0.353 0.353 0.349 rg 0.0123 Tc 0.446 0 Td (ali)Tj 0.255 0.255 0.251 rg 0 Tc 1.083 0 Td (n)Tj 0.353 0.353 0.349 rg 0.496 0 Td (e )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 8 0 0 8 413.14 475.93 Tm (\()Tj 0.51 0.51 0.506 rg 0.426 0 Td (0 )Tj EMC /Suspect <>BDC 0.133 0.133 0.129 rg 1.196 0 Td (\225 )Tj EMC ET BT 0.353 0.353 0.349 rg /T1_1 1 Tf 8 0 0 8 435.212 475.93 Tm (\) )Tj /T1_0 1 Tf 0.0487 Tc 7.6 0 0 7.6 443.51 475.93 Tm (ror )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.0574 0 0 8.5 455.72 475.93 Tm (10 )Tj EMC /Suspect <>BDC 0.0283 Tc 7.6 0 0 7.6 465.59 475.93 Tm (normal )Tj EMC /Suspect <>BDC 0.0041 Tc 3.337 0 Td (\(open )Tj EMC /Suspect <>BDC 0.0323 Tc 2.65 0 Td (sym)Tj 0.51 0.51 0.506 rg 0 Tc 1.834 0 Td (\255)Tj EMC ET BT 0.192 0.192 0.188 rg /T1_0 1 Tf 0.0237 Tc 7.6 0 0 7.6 298.086 466.3312 Tm (bols\) )Tj 0.255 0.255 0.251 rg 0 Tc 7.8001 0 0 7.8001 317.2 466.33 Tm (a)Tj 0.353 0.353 0.349 rg 0.501 0 Td (n)Tj 0.255 0.255 0.251 rg 0.485 0 Td (d )Tj 0.353 0.353 0.349 rg 0.919 0 Td (6 )Tj 0.0147 Tc 7.6 0 0 7.6 339.28 466.33 Tm (asth)Tj 0.255 0.255 0.251 rg 0.0476 Tc 1.714 0 Td (ma)Tj 0.353 0.353 0.349 rg 0.0395 Tc 1.262 0 Td (tic )Tj -0.035 Tc 7.5663 0 0 7.6 373.35 466.33 Tm (\(clo.>BDC /T1_1 1 Tf -0.035 Tc 7.4218 0 0 7.5001 456.82 466.33 Tm (is )Tj EMC ET BT /T1_0 1 Tf 0 Tc 7.8001 0 0 7.8001 465.52 466.33 Tm (a )Tj 0.023 Tc 7.6 0 0 7.6 472.21 466.33 Tm (significant )Tj 0.0411 Tc 4.87 0 Td (linear )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf 0.0182 Tc 7.6 0 0 7.6 298.0104 457.21 Tm (correl)Tj 0.353 0.353 0.349 rg 0.0246 Tc 2.462 0 Td (ation )Tj EMC /Suspect <>BDC 0.05 Tc 7.7769 0 0 7.6 335.91 457.21 Tm (\(y)Tj 0.51 0.51 0.506 rg 0 Tc 7.6 0 0 7.6 342.68 457.21 Tm (=)Tj 0.353 0.353 0.349 rg 0.0147 Tc 0.692 0 Td (l.O)Tj 0.255 0.255 0.251 rg 0.05 Tc 7.6957 0 0 7.6 358.5 457.21 Tm (ix)Tj 0.353 0.353 0.349 rg 8.2388 0 0 7.6 365.59 457.21 Tm (\2674)Tj 0.51 0.51 0.506 rg 0 Tc 7.6 0 0 7.6 372.32 457.21 Tm (.)Tj 0.353 0.353 0.349 rg 0.037 Tc 0.199 0 Td (64; )Tj EMC /Suspect <>BDC 0.0076 Tc 1.905 0 Td (r=0.68; )Tj EMC /Suspect <>BDC -0.035 Tc 6.8468 0 0 7.6 415.21 457.21 Tm (p>BDC 0.353 0.353 0.349 rg /T1_0 1 Tf -0.035 Tc 10.3425 0 0 10.6 505.88 419.28 Tm (FE)Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 517.9 419.28 Tm (V )Tj EMC ET BT /T1_0 1 Tf 10.6 0 0 10.6 297.5048 408.2454 Tm (d)Tj 0.353 0.353 0.349 rg -0.0059 Tc 0.542 0 Td (ec)Tj 0.255 0.255 0.251 rg 0 Tc 0.914 0 Td (r)Tj 0.353 0.353 0.349 rg 0.0377 Tc 0.354 0 Td (ease)Tj 0.255 0.255 0.251 rg 0 Tc 1.858 0 Td [(d )-380(f)]TJ 0.133 0.133 0.129 rg 1.457 0 Td (r)Tj 0.353 0.353 0.349 rg 0.355 0 Td (o)Tj 0.192 0.192 0.188 rg 0.506 0 Td (m )Tj -0.035 Tc 10.4413 0 0 10.6 375.96 408.25 Tm (1.)Tj 0.353 0.353 0.349 rg 0.0081 Tc 10.6 0 0 10.6 383.89 408.25 Tm (72\261)Tj 0.255 0.255 0.251 rg 0 Tc 1.585 0 Td (0)Tj 0.353 0.353 0.349 rg -0.035 Tc 9.9942 0 0 10.6 406.83 408.25 Tm (.3)Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 414.59 408.25 Tm (6 )Tj 0.192 0.192 0.188 rg 1.142 0 Td (t)Tj 0.353 0.353 0.349 rg 0.265 0 Td (o )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf 10.6 0 0 10.6 441.0158 408.25 Tm (0)Tj 0.353 0.353 0.349 rg 0.0186 Tc 0.578 0 Td (.63\261)Tj 0.255 0.255 0.251 rg 0 Tc 1.867 0 Td (0)Tj 0.353 0.353 0.349 rg 0.533 0 Td (.)Tj 0.255 0.255 0.251 rg 0.303 0 Td (1)Tj 0.353 0.353 0.349 rg 0.476 0 Td (3 )Tj EMC /Suspect <>BDC 1.084 0 Td (s)Tj 0.51 0.51 0.506 rg 0.401 0 Td (\267)Tj 0.353 0.353 0.349 rg -0.035 Tc 9.8029 0 0 10.6 499.66 408.25 Tm (t\267)Tj 0.255 0.255 0.251 rg -0.0136 Tc 10.6 0 0 10.6 505.9 408.25 Tm (kP)Tj 0.353 0.353 0.349 rg 0 Tc 1.078 0 Td (a)Tj 0.51 0.51 0.506 rg 0.442 0 Td (\267)Tj 0.353 0.353 0.349 rg 0.284 0 Td (l )Tj EMC /Suspect <>BDC -21.423 -1.042 Td (\()Tj 0.192 0.192 0.188 rg 0.331 0 Td (p)Tj 0.353 0.353 0.349 rg -0.035 Tc 9.9183 0 0 10.6 306.67 397.21 Tm (<0)Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 317.06 397.21 Tm (.)Tj 0.353 0.353 0.349 rg -0.0275 Tc 0.192 0 Td (00)Tj 0.255 0.255 0.251 rg 0 Tc 0.947 0 Td (5)Tj 0.353 0.353 0.349 rg 0.46 0 Td (\) )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf -0.035 Tc 10.2207 0 0 10.6 343.58 397.21 Tm (and )Tj 9.5971 0 0 10.6 364.21 397.21 Tm (fr)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 369.98 397.21 Tm (o)Tj 0.255 0.255 0.251 rg 0.551 0 Td (m )Tj 0.353 0.353 0.349 rg -0.0269 Tc 1.258 0 Td (3.95\2610)Tj 0.255 0.255 0.251 rg 0 Tc 2.662 0 Td (.)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.3438 0 0 10.6 419.88 397.21 Tm (32 )Tj ET BT /Suspect <>BDC 0.192 0.192 0.188 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 435.79 397.21 Tm (L)Tj 0.353 0.353 0.349 rg 0.323 0 Td (O )Tj EMC /Suspect <>BDC 10.6 0 0 10.6 449.22 397.21 Tm (2)Tj 0.255 0.255 0.251 rg 0.483 0 Td (.)Tj 0.353 0.353 0.349 rg 0.236 0 Td (9)Tj 0.255 0.255 0.251 rg 0.452 0 Td (6)Tj 0.353 0.353 0.349 rg 0.464 0 Td (\261)Tj 0.255 0.255 0.251 rg 0.534 0 Td (0)Tj 0.353 0.353 0.349 rg -0.035 Tc 9.2803 0 0 10.6 477.89 397.21 Tm (.5)Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 484.69 397.21 Tm (0 )Tj EMC /Suspect <>BDC 0.192 0.192 0.188 rg /T1_3 1 Tf 9.4 0 0 9.4 495.68 397.21 Tm (I )Tj EMC /Suspect <>BDC 0.353 0.353 0.349 rg /T1_0 1 Tf 8.8 0 0 8.8 504.38 397.21 Tm (\()Tj 0.255 0.255 0.251 rg 0.338 0 Td (U)Tj 0.353 0.353 0.349 rg -0.035 Tc 8.1922 0 0 8.8 511.61 397.21 Tm (TPS\) )Tj EMC /Suspect <>BDC 0 Tc 10.6 0 0 10.6 297.95 386.16 Tm (\()Tj 0.255 0.255 0.251 rg 0.331 0 Td (p)Tj 0.353 0.353 0.349 rg 0.446 0 Td (<)Tj 0.255 0.255 0.251 rg 0.492 0 Td (O)Tj 0.353 0.353 0.349 rg -0.035 Tc 7.5883 0 0 10.6 317.12 386.16 Tm (.OO)Tj 0.192 0.192 0.188 rg 0 Tc 10.6 0 0 10.6 330.65 386.16 Tm (I)Tj 0.353 0.353 0.349 rg -0.0207 Tc 0.317 0 Td (\), )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 345.0978 386.16 Tm (r)Tj 0.353 0.353 0.349 rg -0.0288 Tc 0.308 0 Td (espec)Tj 0.255 0.255 0.251 rg -0.035 Tc 9.2906 0 0 10.6 371.02 386.16 Tm (ti)Tj 0.353 0.353 0.349 rg 10.1053 0 0 10.6 376.78 386.16 Tm (ve)Tj 0.192 0.192 0.188 rg 0 Tc 10.6 0 0 10.6 386.31 386.16 Tm (l)Tj 0.353 0.353 0.349 rg 0.234 0 Td (y)Tj 0.192 0.192 0.188 rg 0.478 0 Td (. )Tj -0.035 Tc 10.4294 0 0 10.6 401.19 386.16 Tm (Th)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 412.69 386.16 Tm [(e )-167(c)]TJ 0.192 0.192 0.188 rg -0.035 Tc 10.1673 0 0 10.6 426.71 386.16 Tm (han)Tj 0.353 0.353 0.349 rg -0.0226 Tc 10.6 0 0 10.6 441.03 386.16 Tm (ge )Tj 0.255 0.255 0.251 rg -0.035 Tc 9.9195 0 0 10.6 455.92 386.16 Tm (in )Tj 9.7344 0 0 10.6 468.94 386.16 Tm (th)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 476.05 386.16 Tm (e )Tj 0.255 0.255 0.251 rg -0.035 Tc 9.1875 0 0 10.6 486.23 386.16 Tm (ri)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 491.91 386.16 Tm (g)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.4051 0 0 10.6 497.27 386.16 Tm (ht )Tj 0.192 0.192 0.188 rg 10.0693 0 0 10.6 510.16 386.16 Tm (lun)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 522.63 386.16 Tm (g )Tj 0.255 0.255 0.251 rg -21.239 -0.995 Td (d)Tj 0.353 0.353 0.349 rg -0.0218 Tc 0.498 0 Td (ose )Tj 0 Tc 1.683 0 Td (v)Tj 0.255 0.255 0.251 rg -0.0229 Tc 0.399 0 Td (ari)Tj 0.353 0.353 0.349 rg 0 Tc 0.996 0 Td (e)Tj 0.255 0.255 0.251 rg 0.454 0 Td (d )Tj -0.035 Tc 9.5971 0 0 10.6 349.81 375.61 Tm (fr)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 355.58 375.61 Tm (o)Tj 0.255 0.255 0.251 rg 0.551 0 Td (m )Tj 0.353 0.353 0.349 rg 1.077 0 Td (-)Tj 0.255 0.255 0.251 rg 0.316 0 Td (6)Tj 0.353 0.353 0.349 rg -0.035 Tc 9.7569 0 0 10.6 381.54 375.61 Tm (2% )Tj 0.192 0.192 0.188 rg 0 Tc 10.6 0 0 10.6 398.85 375.61 Tm (t)Tj 0.353 0.353 0.349 rg 0.265 0 Td (o )Tj 0.255 0.255 0.251 rg 0.865 0 Td (+)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.2731 0 0 10.6 416.5 375.61 Tm (52% )Tj 0 Tc 10.6 0 0 10.6 439.1 375.61 Tm (o)Tj 0.255 0.255 0.251 rg 0.496 0 Td (f )Tj -0.035 Tc 9.0854 0 0 10.6 452.14 375.61 Tm (th)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 459.25 375.61 Tm (e )Tj 0.255 0.255 0.251 rg 0.816 0 Td (d)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.4382 0 0 10.6 473.18 375.61 Tm (ose )Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 490.46 375.61 Tm (d)Tj 0.353 0.353 0.349 rg 0.452 0 Td (e)Tj 0.133 0.133 0.129 rg -0.035 Tc 9.5285 0 0 10.6 500.08 375.61 Tm (li)Tj 0.353 0.353 0.349 rg 9.5735 0 0 10.6 505.9 375.61 Tm (ve)Tj 0.133 0.133 0.129 rg 0 Tc 10.6 0 0 10.6 515.02 375.61 Tm (r)Tj 0.353 0.353 0.349 rg -0.035 Tc 9.7271 0 0 10.6 518.3 375.61 Tm (ed )Tj 0.255 0.255 0.251 rg -0.0297 Tc 10.6 0 0 10.6 297.49 364.56 Tm (at )Tj -0.035 Tc 9.7344 0 0 10.6 309.58 364.56 Tm (th)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 317.17 364.56 Tm (e )Tj 0.192 0.192 0.188 rg 0.869 0 Td (m)Tj 0.353 0.353 0.349 rg 0.672 0 Td (o)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.3449 0 0 10.6 338.88 364.56 Tm (uth )Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 356.03 364.56 Tm (\()Tj 0.255 0.255 0.251 rg -0.035 Tc 10.0509 0 0 10.6 359.98 364.56 Tm (mean )Tj 0.353 0.353 0.349 rg 10.4429 0 0 10.6 385.8 364.56 Tm (-8\261)Tj 0.192 0.192 0.188 rg 0 Tc 10.6 0 0 10.6 400.43 364.56 Tm (1)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.4495 0 0 10.6 404.5 364.56 Tm (5%\) )Tj 0.192 0.192 0.188 rg 10.5732 0 0 10.6 425.65 364.56 Tm (and )Tj 10.3816 0 0 10.6 444.95 364.56 Tm (was )Tj 10.3681 0 0 10.6 465.11 364.56 Tm (not )Tj 0.255 0.255 0.251 rg -0.0211 Tc 10.6 0 0 10.6 481.77 364.56 Tm (sta)Tj 0.133 0.133 0.129 rg -0.035 Tc 9.2906 0 0 10.6 493.42 364.56 Tm (ti)Tj 0.255 0.255 0.251 rg -0.0068 Tc 10.6 0 0 10.6 498.57 364.56 Tm (st)Tj 0.133 0.133 0.129 rg 0 Tc 0.685 0 Td (i)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.5172 0 0 10.6 508.22 364.56 Tm (cally )Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 297.45 353.53 Tm (s)Tj 0.255 0.255 0.251 rg 0.413 0 Td (i)Tj 0.353 0.353 0.349 rg 0.226 0 Td (g)Tj 0.255 0.255 0.251 rg 0.46 0 Td (n)Tj 0.353 0.353 0.349 rg -0.0348 Tc 0.491 0 Td (ifican)Tj 0.255 0.255 0.251 rg 0 Tc 2.179 0 Td (t )Tj 0.353 0.353 0.349 rg /T1_1 1 Tf 9.2 0 0 9.2 346.4 353.53 Tm (\()Tj 0.255 0.255 0.251 rg 0.0151 Tc 0.38 0 Td (fi)Tj 0.353 0.353 0.349 rg 0 Tc 0.62 0 Td (g)Tj 0.255 0.255 0.251 rg 0.555 0 Td (. )Tj 0.353 0.353 0.349 rg /T1_0 1 Tf -0.035 Tc 10.3269 0 0 10.6 369.48 353.53 Tm (3\). )Tj 0.255 0.255 0.251 rg -0.0026 Tc 10.6 0 0 10.6 386.35 353.53 Tm (Pl )Tj 0 Tc 1.444 0 Td (d)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.3941 0 0 10.6 406.45 353.53 Tm (ec)Tj 0.255 0.255 0.251 rg -0.0301 Tc 10.6 0 0 10.6 415.66 353.53 Tm (reased )Tj 0.192 0.192 0.188 rg -0.035 Tc 10.0797 0 0 10.6 447.73 353.53 Tm (from )Tj 0.133 0.133 0.129 rg 10.5178 0 0 10.6 473.88 353.53 Tm (1.42\2610.24 )Tj 0.192 0.192 0.188 rg /T1_1 1 Tf 0.05 Tc 8.7717 0 0 8.5 519.8 353.53 Tm (to )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf -0.035 Tc 9.6955 0 0 10.6 298.22 342.49 Tm (1.)Tj 0.353 0.353 0.349 rg -0.0253 Tc 10.6 0 0 10.6 304.69 342.49 Tm (06\2610.22 )Tj EMC /Suspect <>BDC 0.255 0.255 0.251 rg -0.035 Tc 10.4737 0 0 10.6 342.12 342.49 Tm (\(p)Tj 0.353 0.353 0.349 rg 10.3905 0 0 10.6 350.35 342.49 Tm (<0)Tj 0.255 0.255 0.251 rg 9.9942 0 0 10.6 361.23 342.49 Tm (.0)Tj 0.353 0.353 0.349 rg 10.1724 0 0 10.6 368.5 342.49 Tm (5; )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_1 1 Tf 0.004 Tc 9.4 0 0 9.4 380.62 342.49 Tm (fi)Tj 0.353 0.353 0.349 rg -0.035 Tc 9.3719 0 0 9.4 385.83 342.49 Tm (g. )Tj 0.255 0.255 0.251 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 396.92 342.49 Tm (4)Tj 0.353 0.353 0.349 rg -0.035 Tc 9.9793 0 0 10.6 402.66 342.49 Tm (\). )Tj 0.255 0.255 0.251 rg /T1_3 1 Tf 0.05 Tc 9.9853 0 0 9.5 297.52 319.93 Tm (iii\) )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0093 Tc 10.1 0 0 10.1 312.3 319.93 Tm (0.9% )Tj EMC ET BT 0.192 0.192 0.188 rg /T1_2 1 Tf -0.0023 Tc 10.1 0 0 10.1 337.045 319.93 Tm (NaCl)Tj 0.353 0.353 0.349 rg 0 Tc 2.167 0 Td (. )Tj 0.192 0.192 0.188 rg /T1_0 1 Tf -0.0266 Tc 10.6 0 0 10.6 364.75 319.93 Tm (Premedication )Tj 0.133 0.133 0.129 rg -0.032 Tc 5.799 0 Td (with )Tj 0.255 0.255 0.251 rg -0.0309 Tc 2.071 0 Td (sali)Tj 0.133 0.133 0.129 rg 0 Tc 1.281 0 Td (n)Tj 0.255 0.255 0.251 rg 0.489 0 Td (e )Tj 0.192 0.192 0.188 rg -0.035 Tc 10.3816 0 0 10.6 475.19 319.93 Tm (was )Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 494.31 319.93 Tm (g)Tj 0.133 0.133 0.129 rg -0.035 Tc 10.5807 0 0 10.6 499.11 319.93 Tm (iv)Tj 0.255 0.255 0.251 rg -0.0176 Tc 10.6 0 0 10.6 506.77 319.93 Tm (en )Tj -0.035 Tc 10.3833 0 0 10.6 520.29 319.93 Tm (to )Tj 0.192 0.192 0.188 rg /T1_1 1 Tf -0.0315 Tc 9.4 0 0 9.4 297.56 308.41 Tm (three )Tj 0.133 0.133 0.129 rg /T1_0 1 Tf -0.035 Tc 10.5511 0 0 10.6 322.07 308.41 Tm (norm)Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 343.09 308.41 Tm (a)Tj 0.133 0.133 0.129 rg 0.455 0 Td (l )Tj 0.192 0.192 0.188 rg -0.035 Tc 10.5732 0 0 10.6 355.09 308.41 Tm (and )Tj -0.0094 Tc 10.6 0 0 10.6 374.3 308.41 Tm (one )Tj -0.0184 Tc 1.81 0 Td (asthmatic )Tj 0.255 0.255 0.251 rg -0.0285 Tc 4.162 0 Td (subjects. )Tj 0.192 0.192 0.188 rg -0.035 Tc 10.2249 0 0 10.6 477.55 308.41 Tm (Mean )Tj 0.255 0.255 0.251 rg 10.5139 0 0 10.6 504.33 308.41 Tm (sGaw )Tj 0.192 0.192 0.188 rg 10.2207 0 0 10.6 297.5 297.84 Tm (and )Tj 0.133 0.133 0.129 rg 10.2847 0 0 10.6 316.78 297.84 Tm (mean )Tj 0.192 0.192 0.188 rg /T1_1 1 Tf 0.0278 Tc 9.8 0 0 9.8 342.48 297.84 Tm (FEY )Tj 0.255 0.255 0.251 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 369.93 297.84 Tm (s)Tj 0.133 0.133 0.129 rg 0.375 0 Td (h)Tj 0.255 0.255 0.251 rg -0.0205 Tc 0.445 0 Td (owed )Tj 0.133 0.133 0.129 rg -0.035 Tc 10.4815 0 0 10.6 406.07 297.84 Tm (no )Tj 0.255 0.255 0.251 rg 10.3013 0 0 10.6 420.81 297.84 Tm (si)Tj 0.133 0.133 0.129 rg -0.0117 Tc 10.6 0 0 10.6 427.11 297.84 Tm (gnificant )Tj 0.192 0.192 0.188 rg -0.0307 Tc 3.848 0 Td (changes: )Tj 0.255 0.255 0.251 rg -0.035 Tc 10.3382 0 0 10.6 507.73 297.84 Tm (from )Tj 0.192 0.192 0.188 rg 10.5178 0 0 10.6 298.2 286.81 Tm (1.78\2610.45 )Tj 9.7344 0 0 10.6 342.22 286.81 Tm (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0121 Tc 10.6 0 0 10.6 354.15 286.81 Tm (l.g6\2610.43 )Tj EMC /Suspect <>BDC 0.255 0.255 0.251 rg -0.035 Tc 9.9525 0 0 10.6 397.78 286.81 Tm (s\267)Tj 0 Tc 6.2 0 0 6.2 403.95 290.16 Tm (1)Tj 10.6 0 0 10.6 407.4 286.81 Tm (-)Tj 0.133 0.133 0.129 rg -0.035 Tc 9.6075 0 0 10.6 408.88 286.81 Tm (lcPa)Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 424.58 286.81 Tm (\267)Tj 6.2 0 0 6.2 426.51 290.16 Tm (1 )Tj EMC ET BT 0.192 0.192 0.188 rg /T1_0 1 Tf -0.035 Tc 10.5732 0 0 10.6 433.33 286.81 Tm (and )Tj 10.0797 0 0 10.6 452.05 286.81 Tm (from )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_0 1 Tf -0.0259 Tc 10.6 0 0 10.6 475.08 286.81 Tm (3.01\2610.60 )Tj EMC ET BT 0.192 0.192 0.188 rg /T1_0 1 Tf -0.035 Tc 9.7344 0 0 10.6 519.82 286.81 Tm (to )Tj ET BT /Suspect <>BDC 0.353 0.353 0.349 rg /T1_0 1 Tf -0.0339 Tc 10.6 0 0 10.6 297 275.76 Tm (3.)Tj 0.255 0.255 0.251 rg -0.035 Tc 9.6672 0 0 10.6 304.7 275.76 Tm (01)Tj 0.353 0.353 0.349 rg -0.0295 Tc 10.6 0 0 10.6 314.39 275.76 Tm (\2610.59 )Tj EMC /Suspect <>BDC 0.192 0.192 0.188 rg /T1_3 1 Tf 0 Tc 10.1 0 0 10.1 342.55 275.76 Tm (I )Tj EMC /Suspect <>BDC 0.353 0.353 0.349 rg /T1_0 1 Tf -0.035 Tc 8.429 0 0 9.3 354.62 275.76 Tm (\(BTPS\), )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 390.22 275.76 Tm (r)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.4986 0 0 10.6 393.01 275.76 Tm (es)Tj 0.255 0.255 0.251 rg 10.1447 0 0 10.6 401.78 275.76 Tm (pe)Tj 0.353 0.353 0.349 rg 0.0246 Tc 10.6 0 0 10.6 410.78 275.76 Tm (ct)Tj 0.255 0.255 0.251 rg -0.035 Tc 9.2582 0 0 10.6 418.96 275.76 Tm (iv)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 426.13 275.76 Tm (e)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.1938 0 0 10.6 430.95 275.76 Tm (ly. )Tj 10.0696 0 0 10.6 450.19 275.76 Tm (Ri)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 459.75 275.76 Tm (g)Tj 0.192 0.192 0.188 rg -0.0033 Tc 0.505 0 Td (ht )Tj -0.035 Tc 10.0693 0 0 10.6 482.32 275.76 Tm (lun)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 494.79 275.76 Tm (g )Tj 0.255 0.255 0.251 rg 1.312 0 Td (d)Tj 0.353 0.353 0.349 rg -0.0218 Tc 0.498 0 Td (ose )Tj 0.255 0.255 0.251 rg 0 Tc -20.468 -0.995 Td (d)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.4406 0 0 10.6 301.81 265.21 Tm (ecreased )Tj 9.5458 0 0 10.6 339.85 265.21 Tm (by )Tj 10.2996 0 0 10.6 352.74 265.21 Tm (22\2619.4% )Tj 0.255 0.255 0.251 rg -0.0229 Tc 10.6 0 0 10.6 391.57 265.21 Tm (aft)Tj 0.353 0.353 0.349 rg 0 Tc 0.951 0 Td (e)Tj 0.192 0.192 0.188 rg 0.461 0 Td (r )Tj -0.035 Tc 6.8457 0 0 10.6 413.74 265.21 Tm (tl1)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 420.85 265.21 Tm (e )Tj -0.0248 Tc 0.721 0 Td (seco)Tj 0.255 0.255 0.251 rg -0.035 Tc 9.9824 0 0 10.6 446.39 265.21 Tm (nd )Tj 10.0769 0 0 10.6 459.76 265.21 Tm (inh)Tj 0.353 0.353 0.349 rg 9.9712 0 0 10.6 472.22 265.21 Tm (al)Tj 0.255 0.255 0.251 rg 10.481 0 0 10.6 478.93 265.21 Tm (ati)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 488.54 265.21 Tm (o)Tj 0.192 0.192 0.188 rg 0.507 0 Td (n )Tj 0.353 0.353 0.349 rg 0.804 0 Td (\()Tj 0.192 0.192 0.188 rg 0.282 0 Td (r)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.3055 0 0 10.6 508.69 265.21 Tm (ange )Tj -0.032 Tc 10.6 0 0 10.6 297 254.16 Tm (-6.7% )Tj 0.255 0.255 0.251 rg 0 Tc 2.816 0 Td (t)Tj 0.353 0.353 0.349 rg 0.22 0 Td (o )Tj -0.035 Tc 10.3204 0 0 10.6 339.24 254.16 Tm (-42%; )Tj 0.255 0.255 0.251 rg 9.6938 0 0 10.6 368.53 254.16 Tm (fi)Tj 0.353 0.353 0.349 rg 10.2814 0 0 10.6 374.31 254.16 Tm (g. )Tj 10.0907 0 0 10.6 387.24 254.16 Tm (3\) )Tj 0 Tc 10.6 0 0 10.6 400.81 254.16 Tm (b)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.3588 0 0 10.6 405.6 254.16 Tm (ut )Tj 9.7795 0 0 10.6 418.54 254.16 Tm (thi)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 428.49 254.16 Tm (s )Tj 0.255 0.255 0.251 rg -0.035 Tc 9.8086 0 0 10.6 437.75 254.16 Tm (wa)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 449.61 254.16 Tm (s )Tj 0.192 0.192 0.188 rg 0.828 0 Td (n)Tj 0.353 0.353 0.349 rg 0.444 0 Td (o)Tj 0.255 0.255 0.251 rg 0.505 0 Td (t )Tj 0.353 0.353 0.349 rg 0.717 0 Td [(a )-163(s)]TJ 0.255 0.255 0.251 rg 1.225 0 Td (i)Tj 0.353 0.353 0.349 rg 0.226 0 Td (g)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.5107 0 0 10.6 496.79 254.16 Tm (nifi)Tj 0.353 0.353 0.349 rg 9.8202 0 0 10.6 510.62 254.16 Tm (ca)Tj 0.255 0.255 0.251 rg 10.3967 0 0 10.6 519.83 254.16 Tm (nt )Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 297.02 243.61 Tm (c)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.1673 0 0 10.6 301.43 243.61 Tm (han)Tj 0.353 0.353 0.349 rg -0.0226 Tc 10.6 0 0 10.6 315.75 243.61 Tm (ge)Tj 0.192 0.192 0.188 rg 0 Tc 0.893 0 Td (. )Tj -0.035 Tc 9.7299 0 0 10.6 331.16 243.61 Tm (PI )Tj 0.255 0.255 0.251 rg 0 Tc 11.7 0 0 11.7 344.14 243.61 Tm (w)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.3825 0 0 11.7 350.77 243.61 Tm (as )Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 363.35 243.61 Tm (n)Tj 0.353 0.353 0.349 rg 0.444 0 Td (o)Tj 0.255 0.255 0.251 rg 0.505 0 Td (t )Tj 0.353 0.353 0.349 rg 0.532 0 Td (s)Tj 0.255 0.255 0.251 rg 0.413 0 Td (i)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.1022 0 0 10.6 385.83 243.61 Tm (gn)Tj 0.255 0.255 0.251 rg 10.1892 0 0 10.6 395.92 243.61 Tm (ifi)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 404.54 243.61 Tm (c)Tj 0.255 0.255 0.251 rg -0.0323 Tc 0.407 0 Td (antly )Tj 0.353 0.353 0.349 rg 0 Tc 2.22 0 Td (c)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.1673 0 0 10.6 437.27 243.61 Tm (han)Tj 0.353 0.353 0.349 rg 10.2482 0 0 10.6 451.11 243.61 Tm (ged )Tj 0.255 0.255 0.251 rg 9.8213 0 0 10.6 469.81 243.61 Tm (from )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.9497 0 0 10.6 493.13 243.61 Tm (1.)Tj 0.353 0.353 0.349 rg 10.5466 0 0 10.6 499.57 243.61 Tm (0\2610)Tj 0.192 0.192 0.188 rg 0 Tc 10.6 0 0 10.6 515.3 243.61 Tm (.)Tj 0.353 0.353 0.349 rg -0.035 Tc 9.6688 0 0 10.6 518.07 243.61 Tm (10 )Tj EMC ET BT 0.192 0.192 0.188 rg /T1_0 1 Tf 10.3833 0 0 10.6 297.09 232.57 Tm (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0222 Tc 10.6 0 0 10.6 308.53 232.57 Tm (0.98\2610.32 )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf -0.0336 Tc 10.6 0 0 10.6 353.1454 232.57 Tm (\(fig. )Tj 0.192 0.192 0.188 rg -0.0131 Tc 1.91 0 Td (4\). )Tj 0.353 0.353 0.349 rg /T1_2 1 Tf -0.019 Tc 10.1 0 0 10.1 296.99 210.01 Tm (iv\) )Tj 0 Tc 1.894 0 Td (C)Tj 0.255 0.255 0.251 rg 0.679 0 Td (h)Tj 0.353 0.353 0.349 rg 0.474 0 Td (a)Tj 0.255 0.255 0.251 rg 0.525 0 Td (n)Tj 0.353 0.353 0.349 rg -0.0079 Tc 0.489 0 Td (ges )Tj 0.255 0.255 0.251 rg -0.035 Tc 9.2686 0 0 10.1 356.05 210.01 Tm (in )Tj 0.353 0.353 0.349 rg 0 Tc 10.1 0 0 10.1 367.61 210.01 Tm (a)Tj 0.255 0.255 0.251 rg 0.0163 Tc 0.517 0 Td (ir)Tj 0.353 0.353 0.349 rg 0 Tc 0.721 0 Td (w)Tj 0.255 0.255 0.251 rg 0.568 0 Td (a)Tj 0.353 0.353 0.349 rg 0.507 0 Td (y )Tj 0.0209 Tc 0.918 0 Td (ca)Tj 0.255 0.255 0.251 rg -0.0272 Tc 0.948 0 Td (li)Tj 0.353 0.353 0.349 rg 0 Tc 0.527 0 Td (b)Tj 0.255 0.255 0.251 rg 0.524 0 Td (r)Tj 0.353 0.353 0.349 rg 0.377 0 Td (e )Tj ET BT /Suspect <>BDC 0.255 0.255 0.251 rg /T1_2 1 Tf 0.0148 Tc 10.1 0 0 10.1 432.8964 210.01 Tm (and )Tj EMC ET BT 0.353 0.353 0.349 rg /T1_2 1 Tf 0.0125 Tc 10.1 0 0 10.1 452.0258 210.01 Tm (pene)Tj 0.255 0.255 0.251 rg 0.0055 Tc 1.95 0 Td (tr)Tj 0.353 0.353 0.349 rg 0 Tc 0.623 0 Td (a)Tj 0.255 0.255 0.251 rg -0.0251 Tc 0.518 0 Td (ti)Tj 0.353 0.353 0.349 rg 0 Tc 0.527 0 Td (o)Tj 0.255 0.255 0.251 rg 0.526 0 Td (n )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 10.1 0 0 10.1 502.9197 210.01 Tm (i)Tj 0.353 0.353 0.349 rg 0.293 0 Td (n)Tj 0.255 0.255 0.251 rg 0.475 0 Td (d)Tj 0.353 0.353 0.349 rg 0.05 Tc 10.406 0 0 10.1 515.43 210.01 Tm (ex)Tj 0.51 0.51 0.506 rg 0 Tc 10.1 0 0 10.1 525.02 210.01 Tm (. )Tj EMC ET BT 0.192 0.192 0.188 rg /T1_0 1 Tf -0.035 Tc 10.4294 0 0 10.6 296.55 198.97 Tm (Th)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 308.05 198.97 Tm [(e )-439(c)]TJ 0.255 0.255 0.251 rg 1.593 0 Td (h)Tj 0.353 0.353 0.349 rg 0.444 0 Td (a)Tj 0.255 0.255 0.251 rg 0.462 0 Td (n)Tj 0.353 0.353 0.349 rg 0.0226 Tc 0.4 0 Td (ge )Tj 0.192 0.192 0.188 rg -0.035 Tc 9.9195 0 0 10.6 356.56 198.97 Tm (in )Tj 0.353 0.353 0.349 rg 10.5296 0 0 10.6 371.85 198.97 Tm (sGa)Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 387.82 198.97 Tm (w )Tj 0.353 0.353 0.349 rg -0.035 Tc 9.398 0 0 10.6 403.1 198.97 Tm (fo)Tj 0.255 0.255 0.251 rg 9.5285 0 0 10.6 411.28 198.97 Tm (ll)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 416.54 198.97 Tm (o)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.4454 0 0 10.6 421.43 198.97 Tm (win)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 436.71 198.97 Tm [(g )-422(s)]TJ 0.255 0.255 0.251 rg -0.035 Tc 10.3477 0 0 10.6 453.01 198.97 Tm (aJbutam)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 485.66 198.97 Tm (o)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.0682 0 0 10.6 490.96 198.97 Tm (l, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 503.98 198.97 Tm (m)Tj 0.353 0.353 0.349 rg 0.671 0 Td (e)Tj 0.255 0.255 0.251 rg -0.035 Tc 9.7344 0 0 10.6 515.98 198.97 Tm (th)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 523.56 198.97 Tm (\255)Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf 10.6 0 0 10.6 297.0062 188.4124 Tm (a)Tj 0.353 0.353 0.349 rg 0.408 0 Td (c)Tj 0.192 0.192 0.188 rg 0.46 0 Td (h)Tj 0.353 0.353 0.349 rg 0.445 0 Td (o)Tj 0.133 0.133 0.129 rg 0.499 0 Td (l)Tj 0.353 0.353 0.349 rg 0.272 0 Td (i)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.0807 0 0 10.6 322.07 188.41 Tm (ne )Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 334.94 188.41 Tm (o)Tj 0.255 0.255 0.251 rg 0.506 0 Td (r )Tj 0.353 0.353 0.349 rg 0.05 Tc 11.2052 0 0 10.6 346.88 188.41 Tm (sa)Tj 0.255 0.255 0.251 rg -0.035 Tc 9.9097 0 0 10.6 356.08 188.41 Tm (lin)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 366.13 188.41 Tm (e )Tj 0.255 0.255 0.251 rg 0.824 0 Td (w)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.3825 0 0 10.6 381.97 188.41 Tm (as )Tj 0 Tc 10.6 0 0 10.6 394.89 188.41 Tm (s)Tj 0.255 0.255 0.251 rg 0.323 0 Td (i)Tj 0.353 0.353 0.349 rg 0.272 0 Td (g)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.1353 0 0 10.6 407.03 188.41 Tm (nifi)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 420.38 188.41 Tm (c)Tj 0.255 0.255 0.251 rg -0.0274 Tc 0.407 0 Td (antl)Tj 0.353 0.353 0.349 rg 0 Tc 1.458 0 Td (y )Tj -0.0173 Tc 0.807 0 Td (co)Tj 0.255 0.255 0.251 rg -0.035 Tc 9.8939 0 0 10.6 458.87 188.41 Tm (rr)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 465.01 188.41 Tm (e)Tj 0.255 0.255 0.251 rg -0.0154 Tc 0.455 0 Td (lat)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.2675 0 0 10.6 479.41 188.41 Tm (ed )Tj 0.255 0.255 0.251 rg 10.3688 0 0 10.6 493.43 188.41 Tm (with )Tj 0.192 0.192 0.188 rg 10.3833 0 0 10.6 515.01 188.41 Tm (th)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 522.61 188.41 Tm (e )Tj -21.327 -1.042 Td (c)Tj 0.255 0.255 0.251 rg 0.506 0 Td (h)Tj 0.353 0.353 0.349 rg 0.399 0 Td (a)Tj 0.255 0.255 0.251 rg 0.462 0 Td (n)Tj 0.353 0.353 0.349 rg -0.0226 Tc 0.445 0 Td (ge )Tj 0 Tc 1.811 0 Td (i)Tj 0.255 0.255 0.251 rg 0.279 0 Td (n )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.3022 0 0 10.5 352.27 177.37 Tm (PI )Tj EMC /Suspect <>BDC 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 370.43 177.37 Tm (\()Tj 0.192 0.192 0.188 rg -0.035 Tc 10.0384 0 0 10.6 373.91 177.37 Tm (r=)Tj 0.353 0.353 0.349 rg -0.0191 Tc 10.6 0 0 10.6 382.93 177.37 Tm (0.66, )Tj EMC /Suspect <>BDC 0.255 0.255 0.251 rg 0 Tc 2.367 0 Td (p)Tj 0.353 0.353 0.349 rg -0.035 Tc 8.1491 0 0 10.6 413.24 177.37 Tm (>BDC 0.353 0.353 0.349 rg /C0_0 1 Tf 0 Tc 4.9601 0 0 7.68 349.45 166.33 Tm <00770061007E0020>Tj EMC ET BT 0.255 0.255 0.251 rg /T1_0 1 Tf -0.035 Tc 9.9712 0 0 10.6 369.02 166.33 Tm (al)Tj 0.353 0.353 0.349 rg -0.0034 Tc 10.6 0 0 10.6 376.17 166.33 Tm (so )Tj 0.255 0.255 0.251 rg 0 Tc 1.361 0 Td (f)Tj 0.353 0.353 0.349 rg 0.228 0 Td (o)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.41 0 0 10.6 398.4 166.33 Tm (und )Tj 0.353 0.353 0.349 rg 10.1515 0 0 10.6 418.57 166.33 Tm (be)Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 428.13 166.33 Tm (t)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.016 0 0 10.6 431.03 166.33 Tm (wee)Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 446.87 166.33 Tm (n )Tj 0.353 0.353 0.349 rg 0.852 0 Td (c)Tj 0.255 0.255 0.251 rg 0.46 0 Td (h)Tj 0.353 0.353 0.349 rg 0.444 0 Td (a)Tj 0.255 0.255 0.251 rg 0.462 0 Td (n)Tj 0.353 0.353 0.349 rg -0.0247 Tc 0.445 0 Td (ges )Tj 0.192 0.192 0.188 rg -0.035 Tc 9.2582 0 0 10.6 493.36 166.33 Tm (in )Tj ET BT /Suspect <>BDC 0.353 0.353 0.349 rg /T1_1 1 Tf 0.0389 Tc 9.4 0 0 9.4 504.73 166.33 Tm (FE)Tj 0.255 0.255 0.251 rg 0 Tc 1.351 0 Td (V)Tj 0.353 0.353 0.349 rg /T1_0 1 Tf 6.5001 0 0 6.5001 524.42 163.44 Tm (1 )Tj EMC ET BT 0.192 0.192 0.188 rg /T1_0 1 Tf -0.035 Tc 10.2207 0 0 10.6 297.02 155.76 Tm (and )Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 315.26 155.76 Tm (c)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.1673 0 0 10.6 320.15 155.76 Tm (han)Tj 0.353 0.353 0.349 rg -0.0247 Tc 10.6 0 0 10.6 333.99 155.76 Tm (ges )Tj 0.192 0.192 0.188 rg -0.035 Tc 9.2582 0 0 10.6 351.76 155.76 Tm (in )Tj 0.255 0.255 0.251 rg -0.0182 Tc 10.1 0 0 10.1 362.83 155.76 Tm (PI )Tj ET BT /Suspect <>BDC 0.353 0.353 0.349 rg /T1_0 1 Tf 0 Tc 10.6 0 0 10.6 375.71 155.76 Tm (\()Tj 0.255 0.255 0.251 rg -0.035 Tc 10.0384 0 0 10.6 379.19 155.76 Tm (r=)Tj 0.353 0.353 0.349 rg -0.0304 Tc 10.6 0 0 10.6 388.21 155.76 Tm (0.69, )Tj EMC /Suspect <>BDC 0.255 0.255 0.251 rg 0 Tc 10 0 0 10 412.34 155.76 Tm (p)Tj 0.353 0.353 0.349 rg -0.035 Tc 9.3795 0 0 10 417.07 155.76 Tm (>BDC 0.353 0.353 0.349 rg /T1_2 1 Tf 10.1 0 0 10.1 417.5222 129.37 Tm (o)Tj 0.255 0.255 0.251 rg 0.526 0 Td (w)Tj 0.353 0.353 0.349 rg 0.751 0 Td (p)Tj 0.255 0.255 0.251 rg 0.532 0 Td (w)Tj 0.353 0.353 0.349 rg 0.755 0 Td (. )Tj EMC ET BT 0.255 0.255 0.251 rg /T1_1 1 Tf 0.0076 Tc 9.1 0 0 9.1 452.1 129.37 Tm (Th)Tj 0.353 0.353 0.349 rg 0 Tc 1.21 0 Td (e )Tj 0.255 0.255 0.251 rg /T1_0 1 Tf 10.6 0 0 10.6 473.74 129.37 Tm (m)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.3684 0 0 10.6 481.33 129.37 Tm (ean )Tj 0.192 0.192 0.188 rg 10.5388 0 0 10.6 501.02 129.37 Tm (counts )Tj -0.0227 Tc 10.6 0 0 10.6 296.54 118.32 Tm (obtained )Tj 0.255 0.255 0.251 rg -0.0116 Tc 3.668 0 Td (over )Tj 0.353 0.353 0.349 rg 0 Tc 2.082 0 Td (a )Tj 0.255 0.255 0.251 rg 0.873 0 Td (p)Tj 0.353 0.353 0.349 rg 0.395 0 Td (e)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.0227 0 0 10.6 375.83 118.32 Tm (ri)Tj 0.353 0.353 0.349 rg 10.1631 0 0 10.6 381.98 118.32 Tm (od )Tj 0 Tc 10.6 0 0 10.6 395.9 118.32 Tm (o)Tj 0.255 0.255 0.251 rg 0.542 0 Td (f )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 11.1 0 0 11.1 409.53 118.32 Tm (1)Tj 0.353 0.353 0.349 rg -0.035 Tc 10.6848 0 0 11.1 413.65 118.32 Tm (00 )Tj EMC ET BT /T1_2 1 Tf 0 Tc 11.8 0 0 11.8 428.2 118.32 Tm (s )Tj 0.255 0.255 0.251 rg /T1_0 1 Tf 10.6 0 0 10.6 436.2 118.32 Tm (f)Tj 0.353 0.353 0.349 rg 0.274 0 Td (o)Tj 0.255 0.255 0.251 rg 0.506 0 Td (r )Tj 0.353 0.353 0.349 rg -0.0201 Tc 0.724 0 Td (the )Tj 0.0083 Tc 1.528 0 Td (se)Tj 0.255 0.255 0.251 rg 0 Tc 0.827 0 Td (v)Tj 0.353 0.353 0.349 rg 0.444 0 Td (e)Tj 0.255 0.255 0.251 rg 0.417 0 Td (n )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0349 Tc 10.6 0 0 10.6 495.6448 118.32 Tm ("inhala\255)Tj EMC /Suspect <>BDC 0.192 0.192 0.188 rg -0.035 Tc 10.3789 0 0 10.6 297.09 107.28 Tm (tions" )Tj EMC ET BT /T1_0 1 Tf 10.5807 0 0 10.6 326.31 107.28 Tm (in )Tj 0.133 0.133 0.129 rg 9.7344 0 0 10.6 340.78 107.28 Tm (th)Tj 0.255 0.255 0.251 rg 0 Tc 10.6 0 0 10.6 348.37 107.28 Tm (e )Tj 0.353 0.353 0.349 rg 0.997 0 Td (d)Tj 0.255 0.255 0.251 rg -0.035 Tc 9.9224 0 0 10.6 364.32 107.28 Tm (umm)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 384.95 107.28 Tm [(y )-278(s)]TJ 0.255 0.255 0.251 rg -0.035 Tc 10.4716 0 0 10.6 399.86 107.28 Tm (pon)Tj 0.353 0.353 0.349 rg -0.0243 Tc 10.6 0 0 10.6 415.11 107.28 Tm (ges, )Tj 0 Tc 2.037 0 Td (c)Tj 0.255 0.255 0.251 rg -0.0068 Tc 0.453 0 Td (orr)Tj 0.353 0.353 0.349 rg -0.0306 Tc 1.131 0 Td (ecte)Tj 0.192 0.192 0.188 rg 0 Tc 1.495 0 Td (d )Tj 0.255 0.255 0.251 rg -0.035 Tc 10.33 0 0 10.6 480.85 107.28 Tm (for )Tj 0.192 0.192 0.188 rg -0.0255 Tc 10.6 0 0 10.6 498.15 107.28 Tm (isotope )Tj -0.0249 Tc -19.02 -1.041 Td (decay, )Tj -0.0266 Tc 3.177 0 Td (were )Tj 0.353 0.353 0.349 rg -0.0245 Tc 2.573 0 Td (78,394\2613,653, )Tj 0 Tc 6.206 0 Td (g)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.0499 0 0 10.6 429.04 96.25 Tm (ivin)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 444.39 96.25 Tm [(g )-425(a )]TJ -0.0264 Tc 2.263 0 Td (coe)Tj 0.255 0.255 0.251 rg -0.035 Tc 9.684 0 0 10.6 482.77 96.25 Tm (ffi)Tj 0.353 0.353 0.349 rg 0 Tc 10.6 0 0 10.6 491.9 96.25 Tm (c)Tj 0.133 0.133 0.129 rg 0.454 0 Td (i)Tj 0.255 0.255 0.251 rg -0.035 Tc 10.2675 0 0 10.6 499.09 96.25 Tm (en)Tj 0.133 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Td (show )Tj 0.0419 Tc 2.732 0 Td (any )Tj 0.0169 Tc -22.576 -1.161 Td (relationship )Tj 0.028 Tc 5.307 0 Td (between )Tj 0.0118 Tc 3.938 0 Td (total )Tj 0.0213 Tc 2.165 0 Td (deposition )Tj 0.0419 Tc 4.748 0 Td (and )Tj 0.0245 Tc 1.869 0 Td (airway )Tj 0.0223 Tc 3.235 0 Td (calibre )Tj 0.0419 Tc -21.323 -1.163 Td (and )Tj 0.118 0.118 0.114 rg 0.0195 Tc 1.979 0 Td (there )Tj 0.2 0.2 0.192 rg 0.0336 Tc 2.527 0 Td (was )Tj 0.05 Tc 9.6303 0 0 9.5 119.51 559.92 Tm (no )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0299 Tc 9.5 0 0 9.5 133.35 559.92 Tm (consistent )Tj EMC ET BT /T1_0 1 Tf 0.0228 Tc 9.5 0 0 9.5 177.506 559.92 Tm (difference )Tj 0.0196 Tc 4.659 0 Td (between )Tj 0.118 0.118 0.114 rg 0.0208 Tc 3.888 0 Td (normal )Tj 0.0419 Tc -21.18 -1.161 Td (and )Tj 0.2 0.2 0.192 rg 0.0221 Tc 2.526 0 Td (asthmatic )Tj 0.0244 Tc 4.999 0 Td (subjects. )Tj 0.0314 Tc 4.161 0 Td (Neither )Tj 0.0447 Tc 3.623 0 Td (acute )Tj 0.0229 Tc 2.689 0 Td (bronchodilata\255)Tj 0.0217 Tc -17.991 -1.112 Td (tion )Tj 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505.2105 Tm (bution )Tj 0.05 Tc 10.0163 0 0 9.5 87.26 505.21 Tm (of )Tj 0.0264 Tc 9.5 0 0 9.5 100.24 505.21 Tm (inhaled )Tj 0.0347 Tc 3.484 0 Td (aerosol )Tj 0.032 Tc 3.538 0 Td (confirm )Tj 0.0167 Tc 3.839 0 Td (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0372 Tc 9.5 0 0 9.5 221.6595 505.21 Tm (extend )Tj EMC ET BT /T1_0 1 Tf 0.0165 Tc 9.5 0 0 9.5 253.418 505.21 Tm (those )Tj 0.05 Tc 10.0163 0 0 9.5 278.3 505.21 Tm (of )Tj 0.0476 Tc 9.5 0 0 9.5 57.03 494.65 Tm (other )Tj 0.0283 Tc 2.686 0 Td (workers )Tj 0.0042 Tc 10 0 0 10 119.76 494.65 Tm ([3, )Tj 0.118 0.118 0.114 rg 0.0219 Tc 1.573 0 Td (13-18]. )Tj 0.2 0.2 0.192 rg 0.0482 Tc 9.5 0 0 9.5 170.32 494.65 Tm (Thus, )Tj 0.118 0.118 0.114 rg /T1_2 1 Tf 0.05 Tc 7.4203 0 0 7.2 197.59 494.65 Tm (PAVIA )Tj 0.2 0.2 0.192 rg /T1_1 1 Tf 10.1514 0 0 9.8 225.51 494.65 Tm (et )Tj -0.0193 Tc 9.8 0 0 9.8 237.54 494.65 Tm (al. )Tj /T1_0 1 Tf -0.0199 Tc 10 0 0 10 253.2 494.65 Tm ([13, )Tj 0.118 0.118 0.114 rg -0.0245 Tc 9.5 0 0 9.5 273.75 494.65 Tm (14] )Tj 0.0144 Tc -22.803 -1.162 Td (using )Tj 0.2 0.2 0.192 rg 0 Tc 2.617 0 Td (a )Tj 0.118 0.118 0.114 rg 0.0188 Tc 0.867 0 Td (monodispersive )Tj 0.2 0.2 0.192 rg 0.0179 Tc 6.914 0 Td (aerosol )Tj 0.118 0.118 0.114 rg 0.0168 Tc 3.336 0 Td (demonstrated )Tj 0.0239 Tc 5.969 0 Td (that )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0083 Tc 9.5 0 0 9.5 261.9795 483.611 Tm (alveo\255)Tj EMC ET BT 0.2 0.2 0.192 rg /T1_0 1 Tf 0.05 Tc 9.7034 0 0 9.5 57.04 472.56 Tm (lar )Tj 0.0357 Tc 9.5 0 0 9.5 72.01 472.56 Tm (particle )Tj 0.118 0.118 0.114 rg 0.0269 Tc 3.678 0 Td (deposition )Tj 0.05 Tc 9.6021 0 0 9.5 153.52 472.56 Tm (is )Tj 0.2 0.2 0.192 rg 0 Tc 9.5 0 0 9.5 165.02 472.56 Tm (a )Tj 0.0196 Tc 0.96 0 Td (function )Tj 0.05 Tc 10.0163 0 0 9.5 212.06 472.56 Tm (of )Tj 0.0245 Tc 9.5 0 0 9.5 225.02 472.56 Tm (airway )Tj 0.0195 Tc 3.336 0 Td (calibre, )Tj 0.05 Tc 9.9203 0 0 9.5 56.54 462 Tm (as )Tj 0.0312 Tc 9.5 0 0 9.5 70.06 462 Tm (measured )Tj 0.118 0.118 0.114 rg 0.0201 Tc 4.551 0 Td (by )Tj 0.2 0.2 0.192 rg /T1_2 1 Tf -0.0064 Tc 9.9 0 0 9.9 127.92 462 Tm (FEY )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 6.2 0 0 6.2 147.15 458.65 Tm (1)Tj 0.56 0.54 Td (\225 )Tj EMC ET BT /T1_0 1 Tf 0.0366 Tc 9.5 0 0 9.5 157.36 462 Tm (This )Tj 0.0336 Tc 2.433 0 Td (was )Tj 0.05 Tc 9.5425 0 0 9.5 200.55 462 Tm (confmned )Tj 9.6887 0 0 9.5 246.25 462 Tm (by )Tj -0.035 Tc 8.0057 0 0 8.1 261.08 462 Tm (LAUBE )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0464 Tc 10.2 0 0 10.2 56.55 450.97 Tm (et )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 10.1247 0 0 10.2 69.53 450.97 Tm (al. )Tj /T1_0 1 Tf -0.0102 Tc 9.6 0 0 9.6 86.17 450.97 Tm ([15] )Tj 0.118 0.118 0.114 rg 0.0144 Tc 9.5 0 0 9.5 108.48 450.97 Tm (using )Tj 0.2 0.2 0.192 rg 0 Tc 2.819 0 Td (a )Tj 0.0266 Tc 1.073 0 Td (polydispersive )Tj 0.0157 Tc 6.759 0 Td (aerosol. )Tj 0.0234 Tc 3.883 0 Td (Similarly, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0282 Tc 7.2 0 0 7.2 56.61 439.93 Tm (DOLOVICH )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 10.6747 0 0 9.8 98.78 439.93 Tm (eta/. )Tj /T1_0 1 Tf -0.0046 Tc 9.5 0 0 9.5 124.09 439.93 Tm ([16] )Tj 0.0183 Tc 2.085 0 Td (found )Tj 0 Tc 11.4 0 0 11.4 170.76 439.93 Tm (a )Tj 0.0456 Tc 9.5 0 0 9.5 178.48 439.93 Tm (good )Tj 0.118 0.118 0.114 rg 0.0214 Tc 2.534 0 Td (relationship )Tj 0.2 0.2 0.192 rg 0.0196 Tc 5.307 0 Td (between )Tj 0.0249 Tc -20.624 -1.162 Td (intrapulmonary )Tj 0.0263 Tc 7.021 0 Td (aerosol )Tj 0.0257 Tc 3.649 0 Td (penetrance )Tj 0.05 Tc 9.7132 0 0 9.5 206.78 428.89 Tm (and )Tj 0.118 0.118 0.114 rg 0.0163 Tc 9.5 0 0 9.5 227.02 428.89 Tm (maximal )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0125 Tc 9.5 0 0 9.5 267.338 428.89 Tm (mid\255)Tj EMC ET BT 0.2 0.2 0.192 rg /T1_0 1 Tf 0.0232 Tc 9.5 0 0 9.5 56.5425 417.8415 Tm (expiratory )Tj 0.0229 Tc 4.901 0 Td (flow )Tj 0.0183 Tc 2.485 0 Td (rate. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.8395 0 0 9.5 149.68 417.84 Tm (CHOPRA )Tj EMC ET BT /T1_1 1 Tf 0.0281 Tc 9.8 0 0 9.8 185.19 417.84 Tm (et )Tj -0.035 Tc 10.1247 0 0 10.2 197.69 417.84 Tm (al. )Tj /T1_0 1 Tf -0.0153 Tc 9.6 0 0 9.6 213.85 417.84 Tm ([3] )Tj 0.118 0.118 0.114 rg 0.0127 Tc 9.5 0 0 9.5 230.88 417.84 Tm (used )Tj 0.2 0.2 0.192 rg 0 Tc 2.415 0 Td (a )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.02 Tc 9.5 0 0 9.5 263.8735 417.84 Tm (semi\255)Tj EMC ET BT /T1_0 1 Tf 0.0271 Tc 9.5 0 0 9.5 56.0705 407.276 Tm (quantitative )Tj 0.027 Tc 5.506 0 Td (approach )Tj 0.05 Tc 9.8951 0 0 9.5 150.22 407.28 Tm (to )Tj 0.029 Tc 9.5 0 0 9.5 163.07 407.28 Tm (show )Tj 0.118 0.118 0.114 rg 0.0239 Tc 2.74 0 Td (that )Tj 0.2 0.2 0.192 rg 0.0263 Tc 2.063 0 Td (aerosol )Tj 0.0313 Tc 3.548 0 Td (penetrance )Tj 0.0336 Tc -19.556 -1.161 Td (was )Tj 0 Tc 2.264 0 Td (a )Tj 0.118 0.118 0.114 rg 0.05 Tc 9.5891 0 0 9.5 88.81 396.25 Tm (positive )Tj 0.2 0.2 0.192 rg 0.0412 Tc 9.5 0 0 9.5 128.06 396.25 Tm (function )Tj 0.05 Tc 10.5727 0 0 9.5 168.86 396.25 Tm (of )Tj 0.034 Tc 9.5 0 0 9.5 183.85 396.25 Tm (both )Tj /T1_2 1 Tf 0.0179 Tc 9.9 0 0 9.9 207.6 396.25 Tm (FEV)Tj 0 Tc 5.5001 0 0 5.5001 227.35 392.41 Tm (1 )Tj /T1_0 1 Tf 0.05 Tc 9.7132 0 0 9.5 236.54 396.25 Tm (and )Tj 9.5775 0 0 9.5 257.18 396.25 Tm (airway )Tj 0.0397 Tc 9.5 0 0 9.5 55.59 385.21 Tm (conductance. )Tj -0.035 Tc 8.0697 0 0 9.5 116.01 385.21 Tm (SvARTENGREN )Tj 0.0419 Tc 9.5 0 0 9.5 176.54 385.21 Tm (and )Tj 0.0416 Tc 2.174 0 Td (co-workers )Tj -0.0039 Tc 10 0 0 10 249.84 385.21 Tm ([17, )Tj 0.118 0.118 0.114 rg -0.035 Tc 9.6677 0 0 10 272.79 385.21 Tm (18] )Tj 0.2 0.2 0.192 rg 0.0309 Tc 9.5 0 0 9.5 56.03 374.16 Tm (showed )Tj 0.118 0.118 0.114 rg 0.0239 Tc 4.104 0 Td (that )Tj 0.2 0.2 0.192 rg 0.0281 Tc 2.327 0 Td (bronchoconstriction )Tj 0.0158 Tc 9.345 0 Td (with )Tj 0.118 0.118 0.114 rg 0.0258 Tc 2.677 0 Td (methacholine )Tj 0.0247 Tc -18.492 -1.162 Td (resulted )Tj -0.003 Tc 3.833 0 Td (in )Tj 0.2 0.2 0.192 rg 0 Tc 1.261 0 Td (a )Tj 0.0372 Tc 0.961 0 Td (decrease )Tj 0.118 0.118 0.114 rg -0.003 Tc 4.144 0 Td (in )Tj 0.2 0.2 0.192 rg 0.0353 Tc 1.265 0 Td (24-h )Tj 0.118 0.118 0.114 rg 0.0191 Tc 2.474 0 Td (lung )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0173 Tc 9.5 0 0 9.5 209.74 363.121 Tm (retention )Tj EMC ET BT 0.2 0.2 0.192 rg /T1_0 1 Tf 0.05 Tc 10.5727 0 0 9.5 249.5 363.12 Tm (of )Tj 0 Tc 9.5 0 0 9.5 262.04 363.12 Tm (4 )Tj ET BT /Suspect <>BDC 0.118 0.118 0.114 rg /T1_0 1 Tf -0.035 Tc 7.6068 0 0 10.2 271.64 363.12 Tm (J.Ull )Tj EMC ET BT /T1_0 1 Tf 0.0266 Tc 9.5 0 0 9.5 55.66 352.56 Tm (monodispersive )Tj 0.2 0.2 0.192 rg 0.0265 Tc 7.421 0 Td (Teflon )Tj 0.0331 Tc 3.496 0 Td (particles )Tj 0.118 0.118 0.114 rg -0.003 Tc 4.386 0 Td (in )Tj 0.0309 Tc 1.523 0 Td (normal )Tj 0.2 0.2 0.192 rg 0.0244 Tc 3.676 0 Td (subjects, )Tj 0.0218 Tc -20.514 -1.112 Td (suggesting )Tj 0.0407 Tc 4.862 0 Td (that )Tj 0.0212 Tc 2.021 0 Td (methacholine )Tj 0.0186 Tc 6.005 0 Td (constriction )Tj 0.118 0.118 0.114 rg 0.0204 Tc 5.314 0 Td (reduced )Tj ET BT /Suspect <>BDC 0.2 0.2 0.192 rg /T1_0 1 Tf 0.0286 Tc 9.5 0 0 9.5 263.045 341.996 Tm (pene\255)Tj EMC ET BT /T1_0 1 Tf 0.0122 Tc 9.5 0 0 9.5 55.6505 330.9665 Tm (tration )Tj 0.05 Tc 10.5727 0 0 9.5 87.26 330.97 Tm (of )Tj 0.0331 Tc 9.5 0 0 9.5 101.29 330.97 Tm (particles )Tj 0.0263 Tc 4.285 0 Td (into )Tj 0.118 0.118 0.114 rg 0.048 Tc 2.229 0 Td (the )Tj 0.2 0.2 0.192 rg 0.018 Tc 1.912 0 Td (alveoli. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.7015 0 0 9.5 222.62 330.97 Tm (Our )Tj EMC ET BT /T1_0 1 Tf 0.0206 Tc 9.5 0 0 9.5 244.19 330.97 Tm (study )Tj 0.118 0.118 0.114 rg 0.0181 Tc 2.943 0 Td (has )Tj 0.2 0.2 0.192 rg 0.023 Tc -22.8 -1.162 Td (shown )Tj 0.0407 Tc 3.447 0 Td (that )Tj 0.118 0.118 0.114 rg 0.0249 Tc 2.318 0 Td (intrapulmonary )Tj 0.2 0.2 0.192 rg 0.0313 Tc 7.184 0 Td (penetrance )Tj 0.007 Tc 5.346 0 Td (is )Tj 0 Tc 1.362 0 Td (a )Tj 0.0258 Tc 1.174 0 Td (positive )Tj 0.0234 Tc -20.877 -1.162 Td (linear )Tj 0.0124 Tc 3.131 0 Td (function )Tj 0.118 0.118 0.114 rg 0.05 Tc 10.5727 0 0 9.5 120.86 308.89 Tm (of )Tj 0.2 0.2 0.192 rg 0.0248 Tc 9.5 0 0 9.5 132.97 308.89 Tm (baseline )Tj 0.118 0.118 0.114 rg 0.0245 Tc 3.727 0 Td (airway )Tj 0.2 0.2 0.192 rg 0.0182 Tc 3.235 0 Td (conductance )Tj 0.0419 Tc 5.506 0 Td (and )Tj 0.04 Tc 1.869 0 Td (also )Tj 0.05 Tc 10.5727 0 0 9.5 55.1 298.33 Tm (of )Tj 0.0333 Tc 9.5 0 0 9.5 70.47 298.33 Tm (conductance )Tj 0.0396 Tc 6.013 0 Td (changes )Tj 0.033 Tc 4.154 0 Td (produced )Tj 0.05 Tc 9.6887 0 0 9.5 211.69 298.33 Tm (by )Tj 0.0238 Tc 9.5 0 0 9.5 228.46 298.33 Tm (methacholine, )Tj 0.0155 Tc -18.252 -1.163 Td (salbutamol )Tj 0.118 0.118 0.114 rg 0.0419 Tc 5.308 0 Td (and )Tj 0.2 0.2 0.192 rg 0.0123 Tc 2.271 0 Td (saline. )Tj 0.118 0.118 0.114 rg 0.0229 Tc 3.441 0 Td (Thus, )Tj 0.2 0.2 0.192 rg 0.0208 Tc 3.14 0 Td (normal )Tj 0.0203 Tc 3.676 0 Td (subjects )Tj 0.0209 Tc 4.105 0 Td (when )Tj 0.0286 Tc -21.977 -1.112 Td (bronchoconstricted )Tj 0.118 0.118 0.114 rg 0.0331 Tc 8.832 0 Td (demonstrate )Tj 0.2 0.2 0.192 rg 0 Tc 5.911 0 Td (a )Tj 0.0193 Tc 1.174 0 Td (pattern )Tj 0.05 Tc 10.0163 0 0 9.5 240.86 276.72 Tm (of )Tj 0.0263 Tc 9.5 0 0 9.5 255.74 276.72 Tm (aerosol )Tj 0.0269 Tc -21.169 -1.161 Td (deposition )Tj 0.0389 Tc 4.796 0 Td (similar )Tj -0.0168 Tc 3.397 0 Td (to )Tj 0.118 0.118 0.114 rg 0.0407 Tc 1.213 0 Td (that )Tj 0.2 0.2 0.192 rg 0.0231 Tc 1.959 0 Td (seen )Tj -0.003 Tc 2.279 0 Td (in )Tj 0.0284 Tc 1.16 0 Td (asthmatic )Tj 0.118 0.118 0.114 rg 0.0161 Tc 4.499 0 Td (individuals. )Tj 0.2 0.2 0.192 rg 0.05 Tc 9.679 0 0 9.5 63.28 254.65 Tm (The )Tj 0.0325 Tc 9.5 0 0 9.5 82.47 254.65 Tm (deposition )Tj 0.05 Tc 10.5727 0 0 9.5 128.54 254.65 Tm (of )Tj 0 Tc 9.5 0 0 9.5 140.54 254.65 Tm (a )Tj 0.118 0.118 0.114 rg 0.0353 Tc 0.912 0 Td (large )Tj 0.2 0.2 0.192 rg 0.0261 Tc 2.485 0 Td (proportion )Tj 0.05 Tc 10.5727 0 0 9.5 218.78 254.65 Tm (of )Tj 0.0264 Tc 9.5 0 0 9.5 231.28 254.65 Tm (inhaled )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0329 Tc 9.5 0 0 9.5 263.903 254.65 Tm (aero\255)Tj EMC ET BT /T1_0 1 Tf 0.0359 Tc 9.5 0 0 9.5 54.5895 244.086 Tm (sol )Tj 0.0476 Tc 1.723 0 Td (in )Tj 0.0391 Tc 1.313 0 Td (central )Tj 0.0314 Tc 3.94 0 Td (airways )Tj 0.05 Tc 11.1292 0 0 9.5 161.65 244.09 Tm (of )Tj 0.0269 Tc 9.5 0 0 9.5 180.38 244.09 Tm (asthmatics )Tj 0.05 Tc 9.6021 0 0 9.5 232.24 244.09 Tm (is )Tj 0.118 0.118 0.114 rg 0.0279 Tc 9.5 0 0 9.5 248.65 244.09 Tm (probably )Tj 0.0204 Tc -20.422 -1.162 Td (largely )Tj 0.0409 Tc 4.041 0 Td (due )Tj 0.2 0.2 0.192 rg -0.0168 Tc 2.736 0 Td (to )Tj 0.118 0.118 0.114 rg 0.0364 Tc 1.315 0 Td (narrowing )Tj 0.2 0.2 0.192 rg 0.05 Tc 10.5727 0 0 9.5 178.46 233.05 Tm (of )Tj 0.0181 Tc 9.5 0 0 9.5 192.46 233.05 Tm (these )Tj 0.0307 Tc 2.671 0 Td (central )Tj 0.0273 Tc 3.435 0 Td (airways. )Tj 0.0335 Tc -20.651 -1.162 Td (Narrowing )Tj 0.0384 Tc 5.039 0 Td (causes )Tj 0.118 0.118 0.114 rg 0.0294 Tc 3.292 0 Td (turbulent )Tj 0.2 0.2 0.192 rg 0.0301 Tc 4.286 0 Td (airflow, )Tj 0.0187 Tc 3.852 0 Td (particularly )Tj 0.0489 Tc 5.344 0 Td (at )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0056 Tc 9.5 0 0 9.5 273.6185 222.011 Tm (bi\255)Tj EMC ET BT /T1_0 1 Tf 0.0256 Tc 9.5 0 0 9.5 53.665 211.4375 Tm (furcations )Tj 0.118 0.118 0.114 rg 0.0167 Tc 4.8 0 Td (and )Tj 0.2 0.2 0.192 rg 0.0349 Tc 2.029 0 Td (thus )Tj 0.033 Tc 2.226 0 Td (promotes )Tj 0.118 0.118 0.114 rg 0.0213 Tc 4.436 0 Td (deposition)Tj 0 0.004 0 rg 0 Tc 4.435 0 Td (. )Tj 0.118 0.118 0.114 rg 0.0232 Tc 0.721 0 Td (Inhalation )Tj 0.2 0.2 0.192 rg 0.05 Tc 10.5727 0 0 9.5 275.9 211.44 Tm (of )Tj 0.0323 Tc 9.5 0 0 9.5 54.11 200.89 Tm (salbutamol )Tj ET BT /Suspect <>BDC 0.118 0.118 0.114 rg /T1_0 1 Tf 0.0296 Tc 9.5 0 0 9.5 108.8775 200.89 Tm (increased )Tj EMC ET BT 0.2 0.2 0.192 rg /T1_0 1 Tf 0.0413 Tc 9.5 0 0 9.5 152.511 200.89 Tm (sGaw )Tj 0.0201 Tc 2.945 0 Td (by )Tj /T1_2 1 Tf 0.0157 Tc 9.1 0 0 9.1 195.72 200.89 Tm (74% )Tj /T1_0 1 Tf 0.0419 Tc 9.5 0 0 9.5 219.26 200.89 Tm (and )Tj 0.0215 Tc 2.083 0 Td (penetration )Tj 0.0175 Tc -19.462 -1.162 Td (index )Tj 0.118 0.118 0.114 rg 0.05 Tc 9.6887 0 0 9.5 82.09 189.85 Tm (by )Tj 0.2 0.2 0.192 rg /T1_2 1 Tf 0.0027 Tc 9.1 0 0 9.1 97.89 189.85 Tm (49%. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0476 Tc 9.5 0 0 9.5 125.11 189.85 Tm (Since )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.7985 0 0 9.5 153.52 189.85 Tm (it )Tj 0.0336 Tc 9.5 0 0 9.5 165.11 189.85 Tm (was )Tj 0.0293 Tc 2.215 0 Td (delivered )Tj 0.05 Tc 9.6887 0 0 9.5 229.45 189.85 Tm (by )Tj 0.0228 Tc 9.5 0 0 9.5 245.74 189.85 Tm (the )Tj 0.0486 Tc 1.858 0 Td (same )Tj 0.028 Tc -22.018 -1.163 Td (method )Tj 0.038 Tc 3.68 0 Td (as )Tj 0.0228 Tc 1.524 0 Td (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 6.8001 0 0 6.8001 120.88 182.16 Tm (9)Tj -0.035 Tc 9.4113 0 0 9.5 124.21 178.8 Tm (9arfc )Tj EMC ET BT /T1_0 1 Tf 0.0263 Tc 9.5 0 0 9.5 147.74 178.8 Tm (aerosol )Tj 0.0179 Tc 3.691 0 Td (it )Tj 0.0279 Tc 1.727 0 Td (probably )Tj 0.0278 Tc 4.891 0 Td (deposited )Tj 0.0261 Tc -20.2 -1.111 Td (preferentially )Tj 0.0476 Tc 6.508 0 Td (in )Tj 0.118 0.118 0.114 rg 0.048 Tc 1.674 0 Td (the )Tj 0.2 0.2 0.192 rg 0.0223 Tc 1.66 0 Td (central )Tj 0.0314 Tc 3.687 0 Td (airways )Tj 0.05 Tc 10.5727 0 0 9.5 217.34 168.25 Tm (of )Tj 0.0228 Tc 9.5 0 0 9.5 229.9 168.25 Tm (the )Tj 0.0221 Tc 1.659 0 Td (asthmatic )Tj 0.0275 Tc -20.214 -1.162 Td (subjects )Tj 0.0419 Tc 4.045 0 Td (and )Tj 0.0233 Tc 2.182 0 Td (was, )Tj 0.0211 Tc 2.525 0 Td (therefore, )Tj 0.027 Tc 5.347 0 Td (effective )Tj 0.0476 Tc 4.297 0 Td (in )Tj 0.118 0.118 0.114 rg 0.0238 Tc 1.475 0 Td (promoting )Tj 0.2 0.2 0.192 rg 0.0353 Tc -19.867 -1.112 Td (deeper )Tj 0.0265 Tc 3.295 0 Td (penetration )Tj 0.05 Tc 10.5727 0 0 9.5 135.74 146.65 Tm (of )Tj 0.0316 Tc 9.5 0 0 9.5 149.15 146.65 Tm (subsequ)Tj 0.306 0.306 0.298 rg 0 Tc 3.439 0 Td (e)Tj 0.2 0.2 0.192 rg 0.022 Tc 0.464 0 Td (ntly )Tj 0.0235 Tc 2.163 0 Td (administered )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0203 Tc 9.5 0 0 9.5 263.416 146.65 Tm (aero\255)Tj EMC ET BT /T1_0 1 Tf 0.008 Tc 9.5 0 0 9.5 53.6275 135.611 Tm (sol. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.64 0 0 9.5 62.3 124.57 Tm (One )Tj EMC ET BT /T1_0 1 Tf 0.036 Tc 9.5 0 0 9.5 86.41 124.57 Tm (problem )Tj 0.05 Tc 10.5727 0 0 9.5 123.74 124.57 Tm (of )Tj 9.8542 0 0 9.5 135.75 124.57 Tm (our )Tj 0.0265 Tc 9.5 0 0 9.5 153.58 124.57 Tm (technique )Tj 0.039 Tc 4.488 0 Td (for )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0298 Tc 9.5 0 0 9.5 211.6535 124.57 Tm (measuring )Tj EMC /Suspect <>BDC 0.0143 Tc 5.197 0 Td (depo\255)Tj EMC ET BT /T1_0 1 Tf 0.0158 Tc 9.5 0 0 9.5 53.621 113.5215 Tm (sition )Tj 0.05 Tc 9.6021 0 0 9.5 79.6 113.52 Tm (is )Tj 0.118 0.118 0.114 rg 0.0407 Tc 9.5 0 0 9.5 90.22 113.52 Tm (that )Tj 0.2 0.2 0.192 rg 0.0307 Tc 1.963 0 Td (central )Tj 0.0314 Tc 3.334 0 Td (airways )Tj 0.0497 Tc 3.689 0 Td (can )Tj 0.0376 Tc 1.92 0 Td (only )Tj 0.0266 Tc 2.335 0 Td (be )Tj 0.0167 Tc 1.412 0 Td (visualized )Tj 0.0201 Tc 4.652 0 Td (by )Tj 0.0303 Tc -23.206 -1.162 Td (scanning )Tj 0.0294 Tc 4.66 0 Td (through )Tj 0.048 Tc 4.244 0 Td (the )Tj 0.0354 Tc 2.165 0 Td (overlying )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0206 Tc 9.5 0 0 9.5 206.2245 102.481 Tm ("peripheral" )Tj EMC ET BT 0.118 0.118 0.114 rg /T1_0 1 Tf 0.0276 Tc 9.5 0 0 9.5 262.968 102.481 Tm (lung. )Tj 0.2 0.2 0.192 rg 0.0216 Tc -22.076 -1.162 Td (Penetration )Tj 0.0301 Tc 5.301 0 Td (index )Tj 0.0048 Tc 2.88 0 Td (is, )Tj 0.0211 Tc 1.472 0 Td (therefore, )Tj 0.0281 Tc 4.539 0 Td (an )Tj 0.0204 Tc 1.577 0 Td (under-estimation )Tj 0.05 Tc 10.5727 0 0 9.5 274.94 91.44 Tm (of )Tj 0.0309 Tc 9.5 0 0 9.5 309.02 744.24 Tm (actual )Tj 0.0265 Tc 2.942 0 Td (penetration )Tj 0.0187 Tc 5.154 0 Td (particularly )Tj 0.0477 Tc 5.253 0 Td (where )Tj 0.0283 Tc 3.034 0 Td (peripheral )Tj 0.118 0.118 0.114 rg 0.0358 Tc 4.688 0 Td (deposi)Tj 0.306 0.306 0.298 rg 0 Tc 2.777 0 Td (\255)Tj 0.2 0.2 0.192 rg 0.0049 Tc -23.788 -1.161 Td (tion )Tj 0.05 Tc 9.6021 0 0 9.5 328.72 733.21 Tm (is )Tj 0.118 0.118 0.114 rg 0.0309 Tc 9.5 0 0 9.5 339.35 733.21 Tm (normal )Tj 0.2 0.2 0.192 rg 0.05 Tc 10.0163 0 0 9.5 371.42 733.21 Tm (or )Tj 0.118 0.118 0.114 rg -0.0016 Tc 9.5 0 0 9.5 383.99 733.21 Tm (high )Tj 0.2 0.2 0.192 rg 0.05 Tc 9.9203 0 0 9.5 405.02 733.21 Tm (as )Tj 0.0476 Tc 9.5 0 0 9.5 417.52 733.21 Tm (in )Tj 0.0347 Tc 1.207 0 Td (subjects )Tj 0.0158 Tc 3.903 0 Td (with )Tj 0.0456 Tc 2.266 0 Td (good )Tj 0.0245 Tc 2.524 0 Td (airway )Tj 0.0175 Tc -21.322 -1.112 Td (function. )Tj 0.0229 Tc 4.196 0 Td (Thus, )Tj 0.05 Tc 9.5144 0 0 9.5 375.27 722.65 Tm (our )Tj 0.118 0.118 0.114 rg 0.028 Tc 9.5 0 0 9.5 392.62 722.65 Tm (method )Tj 0.2 0.2 0.192 rg 0.05 Tc 9.5178 0 0 9.5 426.22 722.65 Tm (may )Tj 0.0343 Tc 9.5 0 0 9.5 447.36 722.65 Tm (underestimate )Tj 0.118 0.118 0.114 rg -0.0025 Tc 6.465 0 Td (the )Tj ET BT /Suspect <>BDC 0.2 0.2 0.192 rg /T1_0 1 Tf 0.0104 Tc 9.5 0 0 9.5 524.063 722.65 Tm (dif\255)Tj EMC ET BT /T1_0 1 Tf 0.0128 Tc 9.5 0 0 9.5 309.496 711.611 Tm (ferences )Tj 0.0231 Tc 3.938 0 Td (seen )Tj 0.028 Tc 2.339 0 Td (between )Tj 0.118 0.118 0.114 rg 0.0208 Tc 3.989 0 Td (normal )Tj 0.2 0.2 0.192 rg 0.05 Tc 9.7132 0 0 9.5 439.58 711.61 Tm (and )Tj 0.0284 Tc 9.5 0 0 9.5 458.78 711.61 Tm (asthmatic )Tj 0.0203 Tc 5.049 0 Td (subjects )Tj 0.0326 Tc -20.804 -1.112 Td (with )Tj 0.118 0.118 0.114 rg 0.0252 Tc 2.678 0 Td (regard )Tj 0.2 0.2 0.192 rg 0.0338 Tc 3.485 0 Td (to )Tj 0.0263 Tc 1.608 0 Td (aerosol )Tj 0.029 Tc 3.852 0 Td (penetration. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0431 Tc 9.5 0 0 9.5 475.576 701.046 Tm (Other )Tj EMC ET BT 0.118 0.118 0.114 rg /T1_0 1 Tf 0.0199 Tc 9.5 0 0 9.5 506.3845 701.046 Tm (workers )Tj 0.2 0.2 0.192 rg 0.0101 Tc 10 0 0 10 309.36 690 Tm ([13-18] )Tj 0.118 0.118 0.114 rg 0.0295 Tc 9.5 0 0 9.5 345.11 690 Tm (have )Tj 0.2 0.2 0.192 rg 0.0283 Tc 2.366 0 Td (quantified )Tj 0.0307 Tc 4.699 0 Td (central )Tj 0.0314 Tc 3.839 0 Td (airways )Tj 0.0269 Tc 3.74 0 Td (deposition )Tj 0.038 Tc 4.799 0 Td (as )Tj 0.0407 Tc -23.234 -1.112 Td (that )Tj 0.0205 Tc 2.024 0 Td (proportion )Tj 0.05 Tc 10.0163 0 0 9.5 374.78 679.44 Tm (of )Tj 0.0214 Tc 9.5 0 0 9.5 387.27 679.44 Tm (deposited )Tj 0.0263 Tc 4.496 0 Td (aerosol )Tj 0.0348 Tc 3.546 0 Td (which )Tj 0.007 Tc 3.075 0 Td (is )Tj 0.0321 Tc 1.119 0 Td (removed )Tj 0.118 0.118 0.114 rg 0.0201 Tc -20.461 -1.161 Td (by )Tj 0.0186 Tc 1.462 0 Td (mucociliary )Tj 0.2 0.2 0.192 rg 0.0305 Tc 5.399 0 Td (clearance )Tj 0.0476 Tc 4.397 0 Td (in )Tj 0 Tc 1.211 0 Td (a )Tj 0.0246 Tc 0.909 0 Td (few )Tj 0.118 0.118 0.114 rg 0.0392 Tc 2.031 0 Td (hours)Tj 0.306 0.306 0.298 rg 0 Tc 2.411 0 Td (, )Tj 0.2 0.2 0.192 rg 0.0484 Tc 0.623 0 Td (but )Tj 0.118 0.118 0.114 rg 0.025 Tc 1.765 0 Td (this )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0254 Tc 9.5 0 0 9.5 523.12 668.4105 Tm (dis\255)Tj EMC ET BT 0.2 0.2 0.192 rg /T1_0 1 Tf 0.012 Tc 9.5 0 0 9.5 309.1135 657.362 Tm (tinction )Tj 0.0364 Tc 3.944 0 Td (between )Tj 0.0223 Tc 4.335 0 Td (central )Tj 0.05 Tc 9.7132 0 0 9.5 422.3 657.36 Tm (and )Tj 0.0283 Tc 9.5 0 0 9.5 444.97 657.36 Tm (peripheral )Tj 0.118 0.118 0.114 rg 0.0264 Tc 5.151 0 Td (may )Tj 0.2 0.2 0.192 rg 0.05 Tc 9.7621 0 0 9.5 514.57 657.36 Tm (be )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0348 Tc 9.5 0 0 9.5 527.42 657.36 Tm (al\255)Tj EMC ET BT 0.118 0.118 0.114 rg /T1_0 1 Tf 0.0195 Tc 9.5 0 0 9.5 309.1005 646.796 Tm (tered )Tj 0.05 Tc 10.4373 0 0 9.5 334.47 646.8 Tm (if )Tj 0.2 0.2 0.192 rg 0.0261 Tc 9.5 0 0 9.5 345.99 646.8 Tm (disease )Tj 0.0299 Tc 3.586 0 Td (affects )Tj 0.0223 Tc 3.386 0 Td (central )Tj 0.05 Tc 10.0163 0 0 9.5 445.34 646.8 Tm (or )Tj 0.0227 Tc 9.5 0 0 9.5 459.37 646.8 Tm (peripheral )Tj 0.118 0.118 0.114 rg 0.0215 Tc 4.899 0 Td (rates )Tj 0.2 0.2 0.192 rg 0.05 Tc 10.5727 0 0 9.5 529.82 646.8 Tm (of )Tj 0.0217 Tc 9.5 0 0 9.5 308.55 635.76 Tm (clearance. )Tj 0.0362 Tc 4.706 0 Td (Another )Tj 0.0254 Tc 4.298 0 Td (potential )Tj 0.0321 Tc 4.588 0 Td (inaccuracy )Tj 0.0476 Tc 5.457 0 Td (in )Tj 0.05 Tc 9.5144 0 0 9.5 505.83 635.76 Tm (our )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0133 Tc 9.5 0 0 9.5 523.11 635.76 Tm (cal\255)Tj EMC ET BT /T1_0 1 Tf 0.0197 Tc 9.5 0 0 9.5 308.5525 624.7305 Tm (culation )Tj 0.05 Tc 10.5727 0 0 9.5 344.06 624.73 Tm (of )Tj 0.0138 Tc 9.5 0 0 9.5 356.07 624.73 Tm (central )Tj 0.0167 Tc 3.233 0 Td (and )Tj 0.0283 Tc 1.881 0 Td (peripheral )Tj 0.0219 Tc 4.586 0 Td (activities )Tj 0.118 0.118 0.114 rg 0.007 Tc 4.246 0 Td (is )Tj 0.2 0.2 0.192 rg -0.003 Tc 1.061 0 Td (in )Tj 0.0228 Tc 1.219 0 Td (the )Tj 0.0164 Tc 1.619 0 Td (use )Tj 0.05 Tc 10.5727 0 0 9.5 308.54 614.17 Tm (of )Tj 0.0228 Tc 9.5 0 0 9.5 320.62 614.17 Tm (the )Tj 0.0196 Tc 2.064 0 Td (calibration )Tj 0.118 0.118 0.114 rg 0.0154 Tc 4.9 0 Td (factor )Tj 0.2 0.2 0.192 rg 0.0338 Tc 2.838 0 Td (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0217 Tc 9.5 0 0 9.5 425.272 614.17 Tm (relate )Tj EMC ET BT /T1_0 1 Tf 0.0432 Tc 9.5 0 0 9.5 450.618 614.17 Tm (emitted )Tj 0.038 Tc 3.588 0 Td (counts )Tj 0.0338 Tc 3.191 0 Td (to )Tj 0.0228 Tc 1.213 0 Td (the )Tj 0.0235 Tc -22.947 -1.112 Td (administered )Tj 0.0323 Tc 5.913 0 Td (dose )Tj 0.05 Tc 10.5727 0 0 9.5 387.74 603.61 Tm (of )Tj 0.118 0.118 0.114 rg 0.0201 Tc 9.5 0 0 9.5 400.79 603.61 Tm (radioactivity. )Tj 0.2 0.2 0.192 rg 0.0224 Tc 6.097 0 Td (Strictly, )Tj 0.025 Tc 3.906 0 Td (this )Tj 0.118 0.118 0.114 rg 0.0154 Tc 2.013 0 Td (factor )Tj 0.05 Tc 10.288 0 0 9.5 308.07 592.56 Tm (is )Tj 0.2 0.2 0.192 rg 0.0208 Tc 9.5 0 0 9.5 320.07 592.56 Tm (only )Tj 0.0225 Tc 2.374 0 Td (applicable )Tj -0.0168 Tc 4.859 0 Td (to )Tj 0.0228 Tc 1.314 0 Td (the )Tj 0.038 Tc 1.761 0 Td (counts )Tj 0.0196 Tc 3.283 0 Td (from )Tj 0.0228 Tc 2.636 0 Td (the )Tj 0.0222 Tc 1.82 0 Td (whole )Tj 0.0191 Tc 3.024 0 Td (lung )Tj 0.0209 Tc -22.275 -1.161 Td (when )Tj 0.118 0.118 0.114 rg 0.048 Tc 2.727 0 Td (the )Tj 0.023 Tc 1.711 0 Td (distribution )Tj 0.2 0.2 0.192 rg 0.05 Tc 10.0163 0 0 9.5 401.66 581.53 Tm (of )Tj 0.118 0.118 0.114 rg 0.0228 Tc 9.5 0 0 9.5 414.7 581.53 Tm (the )Tj 0.2 0.2 0.192 rg 0.0263 Tc 1.709 0 Td (aerosolized )Tj 0.118 0.118 0.114 rg 0.027 Tc 5.307 0 Td (isotope )Tj 0.007 Tc 3.537 0 Td (is )Tj 0.2 0.2 0.192 rg 0.0228 Tc 1.168 0 Td (the )Tj 0.0318 Tc -22.9 -1.163 Td (same )Tj 0.038 Tc 2.479 0 Td (as )Tj 0.118 0.118 0.114 rg 0.0239 Tc 1.272 0 Td (that )Tj 0.2 0.2 0.192 rg 0.05 Tc 10.5727 0 0 9.5 362.3 570.48 Tm (of )Tj 0.118 0.118 0.114 rg 0.0228 Tc 9.5 0 0 9.5 374.86 570.48 Tm (the )Tj 0.2 0.2 0.192 rg 0.0093 Tc 1.62 0 Td (perfusion )Tj 0.0231 Tc 4.28 0 Td (scan )Tj 0.118 0.118 0.114 rg 0.0163 Tc 2.228 0 Td (isotope. )Tj 0.2 0.2 0.192 rg 0.0469 Tc 3.636 0 Td (Gamma )Tj 0.0177 Tc (rays )Tj 0.0264 Tc -18.796 -1.112 Td (emitted )Tj 0.0028 Tc 3.587 0 Td (from )Tj 0.026 Tc 2.426 0 Td (different )Tj 0.0346 Tc 4.002 0 Td (parts )Tj 0.05 Tc 11.1292 0 0 9.5 426.13 559.92 Tm (of )Tj 0.048 Tc 9.5 0 0 9.5 438.7 559.92 Tm (the )Tj 0.0359 Tc 1.712 0 Td (lung )Tj 0.118 0.118 0.114 rg 0.0264 Tc 2.28 0 Td (may )Tj 0.2 0.2 0.192 rg 0.05 Tc 10.2502 0 0 9.5 497.29 559.92 Tm (be )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0197 Tc 9.5 0 0 9.5 510.62 559.92 Tm (attenu\255)Tj EMC ET BT /T1_0 1 Tf 0.0388 Tc 9.5 0 0 9.5 308.061 549.356 Tm (ated )Tj 0.0338 Tc 2.585 0 Td (to )Tj 0.0315 Tc 1.508 0 Td (differing )Tj 0.0177 Tc 4.496 0 Td (extents. )Tj 0.0482 Tc 3.998 0 Td (However)Tj 0.306 0.306 0.298 rg 0 Tc 3.98 0 Td (, )Tj 0.2 0.2 0.192 rg 0.0181 Tc 1.024 0 Td (these )Tj 0.0254 Tc 2.883 0 Td (potential )Tj 0.0329 Tc -20.475 -1.161 Td (errors )Tj 0.05 Tc 9.5417 0 0 9.5 334.94 538.33 Tm (are )Tj 0.0287 Tc 9.5 0 0 9.5 351.28 538.33 Tm (independent )Tj 0.05 Tc 11.1292 0 0 9.5 403.09 538.33 Tm (of )Tj 0.0346 Tc 9.5 0 0 9.5 415.58 538.33 Tm (airway )Tj 0.0391 Tc 3.235 0 Td (calibre )Tj 0.0419 Tc 3.283 0 Td (and )Tj 0.0238 Tc 1.967 0 Td (state, )Tj 0.0167 Tc 2.934 0 Td (and )Tj 0.017 Tc -22.678 -1.162 Td (therefore )Tj 0.0276 Tc 4.084 0 Td (are )Tj 0.016 Tc 1.678 0 Td (unlikely )Tj 0.0338 Tc 4.192 0 Td (to )Tj 0.0281 Tc 1.568 0 Td (undermine )Tj 0.05 Tc 9.5144 0 0 9.5 468.39 527.29 Tm (our )Tj 0.0187 Tc 9.5 0 0 9.5 488.55 527.29 Tm (conclusions. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.7015 0 0 9.5 317.18 516.24 Tm (Our )Tj EMC ET BT /T1_0 1 Tf 0.0201 Tc 9.5 0 0 9.5 335.99 516.24 Tm (results )Tj 0.0458 Tc 3.12 0 Td (show )Tj 0.007 Tc 2.639 0 Td (that )Tj 0.048 Tc 1.92 0 Td (the )Tj 0.0278 Tc 1.62 0 Td (pattern )Tj 0.05 Tc 10.5727 0 0 9.5 455.9 516.24 Tm (of )Tj 0.0213 Tc 9.5 0 0 9.5 467.91 516.24 Tm (deposition )Tj 0.0057 Tc 4.758 0 Td (within )Tj 0.0228 Tc -21.576 -1.161 Td (the )Tj 0.0359 Tc 1.712 0 Td (lung )Tj 0.0484 Tc 2.334 0 Td (but )Tj 0.0453 Tc 1.766 0 Td (not )Tj 0.048 Tc 1.818 0 Td (the )Tj 0.0118 Tc 1.718 0 Td (total )Tj 0.0246 Tc 2.317 0 Td (quantity )Tj 0.0341 Tc 3.941 0 Td (deposited )Tj 0.05 Tc 9.6021 0 0 9.5 499.12 505.21 Tm (is )Tj 0.012 Tc 9.5 0 0 9.5 510.16 505.21 Tm (largely )Tj 0.0295 Tc -21.273 -1.112 Td (determined )Tj 0.05 Tc 9.6887 0 0 9.5 358.09 494.65 Tm (by )Tj 0.0346 Tc 9.5 0 0 9.5 372.86 494.65 Tm (airway )Tj 0.0195 Tc 3.437 0 Td (calibre. )Tj 0.05 Tc 9.679 0 0 9.5 440.56 494.65 Tm (The )Tj 0.0447 Tc 9.5 0 0 9.5 461.18 494.65 Tm (effect )Tj 0.05 Tc 10.5727 0 0 9.5 489.5 494.65 Tm (of )Tj 0.026 Tc 9.5 0 0 9.5 502.95 494.65 Tm (different )Tj -20.554 -1.162 Td (patterns )Tj 0.05 Tc 11.1292 0 0 9.5 342.61 483.61 Tm (of )Tj 0.0263 Tc 9.5 0 0 9.5 355.1 483.61 Tm (aerosol )Tj 0.0213 Tc 3.437 0 Td (deposition )Tj 0.0309 Tc 4.749 0 Td (on )Tj 0.0346 Tc 1.464 0 Td (airway )Tj 0.118 0.118 0.114 rg 0.0247 Tc 3.243 0 Td (responsiveness )Tj 0.2 0.2 0.192 rg 0.05 Tc 9.8951 0 0 9.5 307.66 473.05 Tm (to )Tj 0.0348 Tc 9.5 0 0 9.5 320.56 473.05 Tm (inhaled )Tj 0.118 0.118 0.114 rg 0.0262 Tc 3.748 0 Td (bronchoconstrictor )Tj 0.2 0.2 0.192 rg 0.0375 Tc 8.477 0 Td (agents )Tj 0.118 0.118 0.114 rg 0.0204 Tc 3.344 0 Td (remains )Tj 0.0065 Tc 3.942 0 Td (unclear. )Tj 0.2 0.2 0.192 rg -0.035 Tc 7.9581 0 0 9.5 307.64 462 Tm (RUFFIN )Tj /T1_1 1 Tf 0.0281 Tc 9.8 0 0 9.8 340.23 462 Tm (et )Tj /T1_3 1 Tf -0.0077 Tc 9.4 0 0 9.4 352.68 462 Tm (a/. )Tj 0.118 0.118 0.114 rg /T1_0 1 Tf -0.0153 Tc 9.6 0 0 9.6 369.37 462 Tm ([5] )Tj 0.2 0.2 0.192 rg 0.0183 Tc 9.5 0 0 9.5 386.3 462 Tm (found )Tj 0.0407 Tc 3.091 0 Td (that )Tj 0.0377 Tc 2.174 0 Td (when )Tj 0.118 0.118 0.114 rg 0.0267 Tc 2.88 0 Td (histamine )Tj 0.2 0.2 0.192 rg 0.0179 Tc 4.689 0 Td (aerosol )Tj 0.0214 Tc -21.119 -1.161 Td (deposited )Tj 0.0246 Tc 4.659 0 Td (predominantly )Tj -0.003 Tc 6.761 0 Td (in )Tj 0.0228 Tc 1.421 0 Td (the )Tj 0.118 0.118 0.114 rg 0.048 Tc 1.863 0 Td (large )Tj 0.2 0.2 0.192 rg 0.023 Tc 2.777 0 Td (airways )Tj 0.118 0.118 0.114 rg 0.05 Tc 9.7985 0 0 9.5 510.64 450.97 Tm (it )Tj 0.2 0.2 0.192 rg 0.0336 Tc 9.5 0 0 9.5 521.75 450.97 Tm (was )Tj 0.118 0.118 0.114 rg 0.0194 Tc -22.536 -1.162 Td (much )Tj 0.0245 Tc 2.728 0 Td (more )Tj 0.2 0.2 0.192 rg 0.027 Tc 2.467 0 Td (effective )Tj -0.035 Tc 9.2582 0 0 9.5 396.4 439.93 Tm (in )Tj 0.0336 Tc 9.5 0 0 9.5 406.95 439.93 Tm (causing )Tj 0.0245 Tc 3.637 0 Td (airway )Tj 0.0173 Tc 3.235 0 Td (obstruction )Tj 0.0169 Tc 5.111 0 Td (than )Tj 0.0209 Tc -22.433 -1.162 Td (when )Tj 0.118 0.118 0.114 rg 0.05 Tc 9.7985 0 0 9.5 335.92 428.89 Tm (it )Tj 0.2 0.2 0.192 rg 0.0336 Tc 9.5 0 0 9.5 345.11 428.89 Tm (was )Tj 0.118 0.118 0.114 rg 0.0151 Tc 1.962 0 Td (deposited )Tj 0.0182 Tc 4.699 0 Td (diffusely )Tj 0.2 0.2 0.192 rg 0.0181 Tc 4.454 0 Td (throughout )Tj 0.0228 Tc 4.901 0 Td (the )Tj ET BT /Suspect <>BDC 0.118 0.118 0.114 rg /T1_0 1 Tf 0.0041 Tc 9.5 0 0 9.5 516.49 428.89 Tm (bron\255)Tj EMC ET BT 0.2 0.2 0.192 rg /T1_0 1 Tf 0.0253 Tc 9.5 0 0 9.5 307.11 418.326 Tm (chial )Tj -0.0064 Tc 2.887 0 Td (tree. )Tj 0.0273 Tc 2.171 0 Td (However, )Tj 0.0476 Tc 4.493 0 Td (in )Tj 0 Tc 1.564 0 Td (a )Tj 0.0293 Tc 0.82 0 Td (previous )Tj 0.0332 Tc 4.432 0 Td (study )Tj 0.05 Tc 9.5164 0 0 9.5 491.99 418.33 Tm (we )Tj 0.041 Tc 9.5 0 0 9.5 506.75 418.33 Tm (showed )Tj 0.0239 Tc -20.957 -1.163 Td (that )Tj 0.0344 Tc 2.075 0 Td (prior )Tj 0.0225 Tc 2.627 0 Td (bronchoconstriction )Tj 0.029 Tc 8.981 0 Td (\(reducing )Tj 0.0245 Tc 4.596 0 Td (sGaw )Tj 0.05 Tc 9.6887 0 0 9.5 508.81 407.28 Tm (by )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0244 Tc 9.5 0 0 9.5 524.06 407.28 Tm (ap\255)Tj EMC ET BT /T1_0 1 Tf 0.0336 Tc 9.5 0 0 9.5 307.213 396.2505 Tm (proximately )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 9.7988 0 0 9.9 363.72 396.25 Tm (50%\) )Tj EMC ET BT /T1_0 1 Tf 0.0228 Tc 9.5 0 0 9.5 393.51 396.25 Tm (did )Tj 0.05 Tc 9.7838 0 0 9.5 413.75 396.25 Tm (not )Tj 0.0395 Tc 9.5 0 0 9.5 434.3 396.25 Tm (alter )Tj 0.118 0.118 0.114 rg 0.0325 Tc 2.687 0 Td (responsiveness )Tj 0.2 0.2 0.192 rg 0.0338 Tc 7.275 0 Td (to )Tj 0.0267 Tc -23.342 -1.162 Td (histamine )Tj 0.0353 Tc 4.539 0 Td (despite )Tj 0.0228 Tc 3.494 0 Td (the )Tj 0.118 0.118 0.114 rg 0.0303 Tc 1.712 0 Td (inference )Tj 0.2 0.2 0.192 rg 0.0028 Tc 4.394 0 Td (from )Tj 0.118 0.118 0.114 rg 0.048 Tc 2.535 0 Td (the )Tj 0.0259 Tc 1.721 0 Td (present )Tj 0.2 0.2 0.192 rg 0.0332 Tc 3.472 0 Td (study )Tj 0.0407 Tc -21.866 -1.163 Td (that )Tj 0.118 0.118 0.114 rg 0.0082 Tc 2.122 0 Td (this )Tj 0.2 0.2 0.192 rg 0.0353 Tc 2.014 0 Td (degree )Tj 0.05 Tc 10.5727 0 0 9.5 378.14 374.16 Tm (of )Tj 0.0232 Tc 9.5 0 0 9.5 391.59 374.16 Tm (constriction )Tj 0.0332 Tc 5.566 0 Td (would )Tj 0.118 0.118 0.114 rg 0.0295 Tc 3.183 0 Td (have )Tj 0.2 0.2 0.192 rg 0.0172 Tc 2.528 0 Td (promoted )Tj 0.0307 Tc -20.221 -1.162 Td (central )Tj 0.0213 Tc 4.143 0 Td (deposition )Tj 0.05 Tc 10.5727 0 0 9.5 393.5 363.12 Tm (of )Tj 0.118 0.118 0.114 rg 0.0228 Tc 9.5 0 0 9.5 408.46 363.12 Tm (the )Tj 0.0267 Tc 1.871 0 Td (histamine )Tj 0.2 0.2 0.192 rg 0.0229 Tc 4.74 0 Td (aerosol, )Tj 0.0326 Tc 3.9 0 Td (with )Tj 0 Tc 10.9 0 0 10.9 532.21 363.12 Tm (a )Tj 0.0337 Tc 9.5 0 0 9.5 306.23 352.56 Tm (reduction )Tj 0.05 Tc 10.5727 0 0 9.5 349.34 352.56 Tm (of )Tj 0.0265 Tc 9.5 0 0 9.5 362.89 352.56 Tm (penetration )Tj 0.0175 Tc 5.296 0 Td (index )Tj 0.05 Tc 9.6887 0 0 9.5 440.17 352.56 Tm (by )Tj 0.0296 Tc 9.5 0 0 9.5 454.94 352.56 Tm (approximately )Tj /T1_2 1 Tf -0.035 Tc 9.3236 0 0 9.9 518.29 352.56 Tm (35% )Tj /T1_0 1 Tf 0.0109 Tc 9.5 0 0 9.5 306.61 342 Tm (\(fig. )Tj -0.0101 Tc 9.8 0 0 9.8 328.18 342 Tm (5\). )Tj 0.0355 Tc 9.5 0 0 9.5 343.12 342 Tm (Thus, )Tj 0.0265 Tc 2.886 0 Td (taking )Tj 0.05 Tc 9.5144 0 0 9.5 399.75 342 Tm (our )Tj 0.118 0.118 0.114 rg 0.0348 Tc 9.5 0 0 9.5 418.06 342 Tm (two )Tj 0.2 0.2 0.192 rg 0.0301 Tc 2.009 0 Td (studies )Tj 0.0147 Tc 3.447 0 Td (together, )Tj 0.0223 Tc 4.136 0 Td (central )Tj 0.118 0.118 0.114 rg 0.0213 Tc -21.322 -1.161 Td (deposition )Tj 0.007 Tc 4.902 0 Td (is )Tj 0.2 0.2 0.192 rg 0.0399 Tc 1.106 0 Td (seen )Tj 0.118 0.118 0.114 rg 0.0476 Tc 2.329 0 Td (in )Tj 0.2 0.2 0.192 rg 0.036 Tc 1.261 0 Td (asthma, )Tj 0.118 0.118 0.114 rg 0.0484 Tc 3.801 0 Td (but )Tj 0.0166 Tc 1.809 0 Td (its )Tj 0.2 0.2 0.192 rg 0.0346 Tc 1.413 0 Td (effect )Tj 0.0309 Tc 2.881 0 Td (on )Tj 0.118 0.118 0.114 rg 0.0225 Tc 1.524 0 Td (respon\255)Tj 0.2 0.2 0.192 rg 0.0259 Tc -21.032 -1.162 Td (siveness )Tj 0.05 Tc 9.6021 0 0 9.5 343.6 319.93 Tm (is )Tj 0.022 Tc 9.5 0 0 9.5 354.11 319.93 Tm (slight. )Tj 0.0273 Tc -4.033 -1.162 Td (However, )Tj 0.0228 Tc 4.6 0 Td (the )Tj 0.0118 Tc 1.718 0 Td (total )Tj 0.0246 Tc 2.317 0 Td (quantity )Tj 0.05 Tc 10.5727 0 0 9.5 434.78 308.89 Tm (of )Tj 0.0488 Tc 9.5 0 0 9.5 447.75 308.89 Tm (drug )Tj 0.0264 Tc 2.426 0 Td (inhaled )Tj 0.118 0.118 0.114 rg 0.0263 Tc 3.537 0 Td (into )Tj -0.0025 Tc 2.128 0 Td (the )Tj 0.2 0.2 0.192 rg 0.0181 Tc -22.945 -1.112 Td (lungs )Tj 0.0264 Tc 3.038 0 Td (may )Tj 0.05 Tc 9.7621 0 0 9.5 360.01 298.33 Tm (be )Tj 0.118 0.118 0.114 rg 0.0245 Tc 9.5 0 0 9.5 377.26 298.33 Tm (more )Tj 0.2 0.2 0.192 rg 0.0281 Tc 2.924 0 Td (important )Tj 0.0476 Tc 4.8 0 Td (in )Tj 0.118 0.118 0.114 rg 0.0235 Tc 1.616 0 Td (determining )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0229 Tc 9.5 0 0 9.5 521.2705 298.33 Tm (res\255)Tj EMC ET BT 0.2 0.2 0.192 rg /T1_0 1 Tf 0.0259 Tc 9.5 0 0 9.5 306.2475 287.2815 Tm (ponsiveness. )Tj 0.0355 Tc 6.003 0 Td (Thus, )Tj -0.035 Tc 7.9937 0 0 9.5 392.13 287.28 Tm (WANNER )Tj /T1_1 1 Tf 0.0281 Tc 9.8 0 0 9.8 431.91 287.28 Tm (et )Tj -0.015 Tc 10.2 0 0 10.2 444.89 287.28 Tm (al. )Tj /T1_0 1 Tf 0.0065 Tc 9.6 0 0 9.6 462.01 287.28 Tm ([19] )Tj 0.0309 Tc 9.5 0 0 9.5 484.67 287.28 Tm (showed )Tj 0.0239 Tc 3.852 0 Td (that )Tj 0.0296 Tc -22.647 -1.112 Td (some )Tj 0.05 Tc 10.5727 0 0 9.5 330.62 276.72 Tm (of )Tj 0.0228 Tc 9.5 0 0 9.5 342.7 276.72 Tm (the )Tj 0.0148 Tc 1.661 0 Td (inter-subject )Tj 0.0095 Tc 5.564 0 Td (variability )Tj 0.118 0.118 0.114 rg -0.003 Tc 4.642 0 Td (in )Tj 0.2 0.2 0.192 rg 0.0222 Tc 1.172 0 Td (bronchial )Tj 0.0141 Tc 4.242 0 Td (respon\255)Tj 0.0259 Tc -21.133 -1.161 Td (siveness )Tj 0.0338 Tc 4.155 0 Td (to )Tj 0.0264 Tc 1.459 0 Td (inhaled )Tj 0.118 0.118 0.114 rg 0.0267 Tc 3.797 0 Td (histamine )Tj 0.2 0.2 0.192 rg 0.0336 Tc 4.699 0 Td (was )Tj 0.0258 Tc 2.264 0 Td (accounted )Tj 0.0137 Tc 4.952 0 Td (for )Tj 0.118 0.118 0.114 rg 0.0201 Tc 1.831 0 Td (by )Tj 0.2 0.2 0.192 rg 0.022 Tc -23.152 -1.112 Td (differences )Tj -0.035 Tc 9.2582 0 0 9.5 357.04 255.13 Tm (in )Tj 0.118 0.118 0.114 rg 0.0228 Tc 9.5 0 0 9.5 370.54 255.13 Tm (the )Tj 0.2 0.2 0.192 rg 0.0492 Tc 1.862 0 Td (dose )Tj 0.05 Tc 10.5727 0 0 9.5 412.7 255.13 Tm (of )Tj 0.118 0.118 0.114 rg 0.033 Tc 9.5 0 0 9.5 427.19 255.13 Tm (histamine )Tj 0.2 0.2 0.192 rg 0.017 Tc 4.749 0 Td (retained )Tj 0.0476 Tc 3.984 0 Td (in )Tj 0.0228 Tc 1.472 0 Td (the )Tj 0.0201 Tc -22.947 -1.162 Td (airways. )Tj 0.0271 Tc 3.948 0 Td (With )Tj 0.0348 Tc 2.875 0 Td (inhaled )Tj 0.0321 Tc 3.535 0 Td (atropine )Tj 0.05 Tc 9.5164 0 0 9.5 441.59 244.09 Tm (we )Tj 0.118 0.118 0.114 rg 0.0463 Tc 9.5 0 0 9.5 456.95 244.09 Tm (have )Tj 0.2 0.2 0.192 rg 0.0242 Tc 2.375 0 Td (recently )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.026 Tc 9.5 0 0 9.5 515.432 244.09 Tm (dem\255)Tj EMC /Suspect <>BDC 0.0311 Tc -22.08 -1.162 Td (onstrated )Tj EMC ET BT 0.118 0.118 0.114 rg /T1_0 1 Tf 0.0407 Tc 9.5 0 0 9.5 347.0255 233.051 Tm (that )Tj 0.048 Tc 2.072 0 Td (the )Tj 0.2 0.2 0.192 rg 0.0394 Tc 1.76 0 Td (amount )Tj 0.05 Tc 10.5727 0 0 9.5 417.98 233.05 Tm (of )Tj 0.0307 Tc 9.5 0 0 9.5 430.47 233.05 Tm (central )Tj 0.0245 Tc 3.384 0 Td (airway )Tj 0.0213 Tc 3.336 0 Td (deposition )Tj 0.0248 Tc -19.808 -1.112 Td (\(which )Tj 0.007 Tc 3.489 0 Td (is )Tj 0.0288 Tc 1.314 0 Td (largely )Tj 0.0295 Tc 3.485 0 Td (determined )Tj 0.05 Tc 9.6887 0 0 9.5 435.85 222.49 Tm (by )Tj 0.118 0.118 0.114 rg 0.0228 Tc 9.5 0 0 9.5 451.66 222.49 Tm (the )Tj 0.2 0.2 0.192 rg 0.0245 Tc 1.869 0 Td (total )Tj 0.0346 Tc 2.428 0 Td (pulmonary )Tj 0.0262 Tc -19.665 -1.163 Td (deposition\) )Tj 0.05 Tc 9.6021 0 0 9.5 356.08 211.44 Tm (is )Tj 0 Tc 9.5 0 0 9.5 367.58 211.44 Tm (a )Tj 0.118 0.118 0.114 rg 0.0376 Tc 1.019 0 Td (major )Tj 0.2 0.2 0.192 rg 0.0255 Tc 2.973 0 Td (factor )Tj 0.0285 Tc 2.982 0 Td (determining )Tj 0.118 0.118 0.114 rg 0.0228 Tc 5.666 0 Td (the )Tj 0.2 0.2 0.192 rg 0.0353 Tc 2.266 0 Td (degree )Tj 0.05 Tc 10.5727 0 0 9.5 305.66 200.89 Tm (of )Tj 0.118 0.118 0.114 rg 0.0245 Tc 9.5 0 0 9.5 317.74 200.89 Tm (muscarinic )Tj 0.2 0.2 0.192 rg 0.0228 Tc 5.044 0 Td (antagonism )Tj 0.0258 Tc 5.266 0 Td (produced )Tj 0.05 Tc 9.6887 0 0 9.5 456.49 200.89 Tm (by )Tj 0.018 Tc 9.5 0 0 9.5 470.8 200.89 Tm (inhaled )Tj 0.0248 Tc 3.434 0 Td (atropine )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0077 Tc 9.6 0 0 9.6 306.01 190.33 Tm ([20]. )Tj EMC ET BT /T1_0 1 Tf 0.0407 Tc 9.5 0 0 9.5 314.81 179.29 Tm (In )Tj 0.0292 Tc 1.261 0 Td (conclusion, )Tj 0.118 0.118 0.114 rg 0.0353 Tc 5.256 0 Td (large )Tj 0.2 0.2 0.192 rg 0.0232 Tc 2.526 0 Td (inter-subject )Tj 0.022 Tc 5.658 0 Td (differences )Tj 0.05 Tc 9.5417 0 0 9.5 501.98 179.29 Tm (are )Tj 0.0231 Tc 9.5 0 0 9.5 518.27 179.29 Tm (seen )Tj -0.003 Tc -22.378 -1.162 Td (in )Tj 0.0118 Tc 1.219 0 Td (total )Tj 0.0359 Tc 2.217 0 Td (lung )Tj 0.0179 Tc 2.272 0 Td (aerosol )Tj 0.0244 Tc 3.386 0 Td (deposition, )Tj 0.0419 Tc 5.001 0 Td (and )Tj 0.0307 Tc 1.928 0 Td (these )Tj 0.0264 Tc 2.577 0 Td (may )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0219 Tc 9.5 0 0 9.5 502.5475 168.251 Tm (reasona\255)Tj EMC ET BT /T1_0 1 Tf 0.0231 Tc 9.5 0 0 9.5 305.7645 157.212 Tm (bly )Tj /T1_2 1 Tf -0.035 Tc 9.1853 0 0 9.9 322.38 157.21 Tm (be )Tj /T1_0 1 Tf 0.0372 Tc 9.5 0 0 9.5 335.9 157.21 Tm (expected )Tj 0.118 0.118 0.114 rg 0.0338 Tc 4.253 0 Td (to )Tj 0.0302 Tc 1.257 0 Td (influence )Tj 0.2 0.2 0.192 rg 0.0231 Tc 4.353 0 Td (responsiveness. )Tj 0.0273 Tc 7.071 0 Td (However, )Tj 0.0384 Tc -20.158 -1.112 Td (mean )Tj 0.0245 Tc 2.88 0 Td (total )Tj 0.0269 Tc 2.468 0 Td (deposition )Tj 0.05 Tc 9.6021 0 0 9.5 403.6 146.65 Tm (is )Tj 0.02 Tc 9.5 0 0 9.5 416.15 146.65 Tm (not )Tj 0.0386 Tc 1.861 0 Td (different )Tj 0.0476 Tc 4.245 0 Td (in )Tj 0.0208 Tc 1.422 0 Td (normal )Tj 0.0167 Tc 3.527 0 Td (and )Tj 0.0284 Tc -22.737 -1.162 Td (asthmatic )Tj 0.0446 Tc 4.549 0 Td (groups )Tj 0.0419 Tc 3.383 0 Td (and )Tj 0.007 Tc 2.023 0 Td (is)Tj 0.306 0.306 0.298 rg 0 Tc 0.7 0 Td (, )Tj 0.2 0.2 0.192 rg 0.0211 Tc 0.772 0 Td (therefore, )Tj 0.016 Tc 4.549 0 Td (unlikely )Tj 0.0338 Tc 3.939 0 Td (to )Tj 0.0186 Tc 1.255 0 Td (explain )Tj 0.041 Tc -21.171 -1.162 Td [(asthmatic )-519(hyperresponsiveness. )]TJ 0.0373 Tc 15.164 0 Td (Preferential )Tj 0.0347 Tc 5.905 0 Td (aerosol )Tj 0.0269 Tc -21.068 -1.113 Td (deposition )Tj 0.0476 Tc 4.902 0 Td (in )Tj 0.0223 Tc 1.313 0 Td (central )Tj 0.0314 Tc 3.384 0 Td (airways )Tj 0.0323 Tc 3.791 0 Td (does )Tj 0.044 Tc 2.425 0 Td (occur )Tj 0.118 0.118 0.114 rg -0.035 Tc 9.2582 0 0 9.5 482.8 114 Tm (in )Tj 0.2 0.2 0.192 rg 0.0326 Tc 9.5 0 0 9.5 494.78 114 Tm (asthma )Tj 0.009 Tc 9.8 0 0 9.8 527.5 114 Tm (to )Tj 0.0281 Tc 9.5 0 0 9.5 305.18 102.48 Tm (an )Tj 0.0313 Tc 1.516 0 Td (extent )Tj 0.118 0.118 0.114 rg 0.0239 Tc 3.192 0 Td (that )Tj 0.2 0.2 0.192 rg 0.0283 Tc 2.064 0 Td (depends )Tj 0.05 Tc 9.7902 0 0 9.5 407.43 102.48 Tm (on )Tj 0.0245 Tc 9.5 0 0 9.5 422.78 102.48 Tm (airway )Tj 0.0307 Tc 3.386 0 Td (calibre )Tj 0.118 0.118 0.114 rg 0.0484 Tc 3.396 0 Td (but )Tj 0.2 0.2 0.192 rg 0.0239 Tc 1.858 0 Td (appears )Tj 0.118 0.118 0.114 rg 0.0338 Tc -21.011 -1.111 Td (to )Tj 0.0295 Tc 1.214 0 Td (have )Tj 0.2 0.2 0.192 rg 0.0214 Tc 2.418 0 Td (little )Tj 0.0447 Tc 2.272 0 Td (effect )Tj 0.05 Tc 9.7902 0 0 9.5 388.23 91.93 Tm (on )Tj 0.0231 Tc 9.5 0 0 9.5 402.23 91.93 Tm (responsiveness. )Tj ET endstream endobj 28 0 obj <>/Filter/JBIG2Decode/Height 1752/ImageMask true/Length 24974/Name/X/Subtype/Image/Type/XObject/Width 1240>>stream 5l  v@"\QX/od h@;V(ꕁhF)dz( JKm_zuh;ALjZA ʍ.CGB"2-}7>>Hi%/Хt ]CX#ddfB4|8P)lZԌ9G" j`0ڳ3ڏl͎kBݘvLQFZL8~ͭ,容ߘ*[rV>m䴩T~rm2_/_BvX9}d즈n¦l*hFe7zWP򽙒sCzqhH!TP tv<_tM޵RTV-qBos-!Cf"ԱMcfzhWЗ; e=W4$dp0U,ozռ8&j2s0#G[/G D:ǺBQ%h|A\MNڒE+K mYmlr:Pk|GttA9_6Nii2н"ui迅22#[h Tr;#|_6x>VbyS(E@+5/ȁx,ܮITN`=džlO) \Pd`.kl_f0`3W Ϋ},tYU"16(Q*AN,?G<3M~!dZ9:`=YICԈOՃb3 rS}T+ p+ϊ-o#kx=pvrɰx&97QAf`h鳣J*Z!EIQTEirHv=|b1KT :)[.]%QmO!$Fv,S=Nh ӮziQɤ^ex<`qHB* hhB@Ԃ^&pF_oI-0[/IhOR}Y}k yUI>+̴밅!b%V&c %(؝;/Q:E!A>\}|rܮzao_FG(~]gd< WEK#e}IfO侾mRWpS$",ۨho˚ASh9`j\YiQW+Ea@<W V쏉'(zWqn %y=x]3 udh0BD i) |63?;.Gs g֗[@[U=XR/aJĥtӲ< >wT 8,#  \ \qƊ Kg!;(Y"+#]Ќ9NĬ (;Dy`d5R)>#ώ}Q&@2;Ӓ1~gBЊY*2Q!6@EvGɅ`+G`!Kc`/ \Lj:~Dºݖ Gm VV A_7/$1&VZ^35l!pW2̳F}U/rGьvRf Bpq K,!pneK0bKVƓV,[g]~e ^=Znƴ@) UPxђoqC3b,ݦo?,fYm qOi>@ټ-w?zh+%iƯvW n3k;Xc8eT t8`&;5>h%E 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Tf 0.05 Tc 7.5078 0 0 7.4001 256.79 725.05 Tm (manu)Tj 0.38 0.38 0.372 rg 0 Tc 7.4001 0 0 7.4001 274.96 725.05 Tm (\255)Tj 0.318 0.318 0.31 rg 0.0235 Tc 7.8001 0 0 7.8001 88.69 716.41 Tm (script. )Tj 0.247 0.251 0.243 rg 0.0287 Tc 8.9 0 0 8.9 142.52 696.73 Tm (References )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_1 1 Tf 0.05 Tc 9.6149 0 0 9.1 49.66 677.05 Tm (I. )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf 9.344 0 0 8.9 61.4 677.05 Tm (Br)Tj 0.38 0.38 0.372 rg -0.0112 Tc 8.9 0 0 8.9 70.95 677.05 Tm (ain )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.035 Tc 8.98 0 0 9.6 85.39 677.05 Tm (JD, )Tj 0.247 0.251 0.243 rg -0.0166 Tc 8.9 0 0 8.9 100.78 677.05 Tm (Val)Tj 0.38 0.38 0.372 rg 0.0045 Tc 1.46 0 Td (bcrg )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0282 Tc 8.9 0 0 8.9 133.4074 677.05 Tm (PA.)Tj 0.525 0.525 0.514 rg 0 Tc 1.773 0 Td (-)Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 8.9 0 0 8.9 157.8913 677.05 Tm (Deposition )Tj 0.38 0.38 0.372 rg 0.05 Tc 8.9033 0 0 8.9 200.56 677.05 Tm (of )Tj -0.0116 Tc 8.9 0 0 8.9 211.59 677.05 Tm (aerosol )Tj 0.247 0.251 0.243 rg -0.0058 Tc 3.238 0 Td (in )Tj 0.0114 Tc 1.138 0 Td (the )Tj 0.0221 Tc 1.565 0 Td (res\255)Tj 0.38 0.38 0.372 rg 0.004 Tc -24.267 -1.133 Td (piratory )Tj 0.0055 Tc 3.61 0 Td (trac)Tj 0.247 0.251 0.243 rg 0 Tc 1.507 0 Td (L )Tj 0.318 0.318 0.31 rg /T1_2 1 Tf 0.05 Tc 8.7132 0 0 8.6 101.89 666.97 Tm (Am )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0001 Tc 9 0 0 9 117.67 666.97 Tm (Rev )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_2 1 Tf 0 Tc 9 0 0 9 134.473 666.97 Tm (R)Tj 0.38 0.38 0.372 rg 0.0239 Tc 0.57 0 Td (espir )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_2 1 Tf -0.0139 Tc 9 0 0 9 161.374 666.97 Tm (Dis. )Tj EMC ET BT /T1_0 1 Tf -0.0188 Tc 8.9 0 0 8.9 180.17 666.97 Tm (1979, )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 203.6927 666.97 Tm (1)Tj 0.38 0.38 0.372 rg 0.0047 Tc 0.407 0 Td (20, )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0201 Tc 8.9 0 0 8.9 222.4183 666.97 Tm (1325-1373. )Tj 0.463 0.463 0.455 rg 0.024 Tc -19.602 -1.133 Td (2. )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0013 Tc 8.9 0 0 8.9 62.9303 656.8863 Tm (Newman )Tj EMC /Suspect <>BDC -0.0165 Tc 4.022 0 Td (SP, )Tj EMC ET BT /T1_0 1 Tf -0.0057 Tc 8.9 0 0 8.9 115.1822 656.8863 Tm (Agnew )Tj 0.247 0.251 0.243 rg -0.0272 Tc 3.287 0 Td (JE, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0116 Tc 8.9 0 0 8.9 159.8068 656.8863 Tm (Pavia )Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg 0.05 Tc 9.8665 0 0 8.9 183.26 656.89 Tm (0, )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 195.27 656.89 Tm (C)Tj 0.247 0.251 0.243 rg 0.649 0 Td (l)Tj 0.38 0.38 0.372 rg -0.012 Tc 0.375 0 Td (arke )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0057 Tc 8.9 0 0 8.9 223.038 656.89 Tm (SW. )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 241.817 656.89 Tm (-)Tj 0.0155 Tc 0.921 0 Td (Inhaled )Tj 0.38 0.38 0.372 rg -0.0043 Tc -22.655 -1.079 Td (aerosols: )Tj 0.247 0.251 0.243 rg -0.0107 Tc 4.047 0 Td (lun)Tj 0.38 0.38 0.372 rg 0 Tc 1.24 0 Td (g )Tj 0.318 0.318 0.31 rg 0.0059 Tc 0.916 0 Td (deposition )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0121 Tc 8.9 0 0 8.9 144.8604 647.2869 Tm (and )Tj EMC ET BT /T1_0 1 Tf 0.007 Tc 8.9 0 0 8.9 161.183 647.2869 Tm (clinical )Tj 0.38 0.38 0.372 rg 0.0004 Tc 3.452 0 Td (applications. )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_2 1 Tf 0.0164 Tc 9 0 0 9 240.78 647.29 Tm (Clin )Tj EMC /Suspect <>BDC 0.007 Tc 2.108 0 Td (Phys )Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg -0.0113 Tc -23.52 -1.12 Td (Plrysiol )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg 0 Tc 3.789 0 Td (M)Tj 0.38 0.38 0.372 rg -0.0073 Tc 0.834 0 Td (eas, )Tj EMC ET BT /T1_0 1 Tf 0.0216 Tc 8.9 0 0 8.9 106.73 637.21 Tm (1982, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.4353 0 0 8.9 129.97 637.21 Tm (3, )Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg 0 Tc 8.9 0 0 8.9 141.77 637.21 Tm (1)Tj 0.525 0.525 0.514 rg 0.347 0 Td (-)Tj 0.38 0.38 0.372 rg 0.0047 Tc 0.545 0 Td (20. )Tj EMC ET BT /T1_0 1 Tf 0.042 Tc 8.9 0 0 8.9 47.9017 627.1174 Tm (3. )Tj 0.0223 Tc 1.673 0 Td (Chop)Tj 0.247 0.251 0.243 rg 0 Tc 2.22 0 Td (r)Tj 0.38 0.38 0.372 rg 0.315 0 Td (a )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0083 Tc 8.9 0 0 8.9 93.443 627.1174 Tm (SK. )Tj EMC /Suspect <>BDC 0.0212 Tc 1.897 0 Td (Taplin )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg -0.0035 Tc 3.181 0 Td (GV, )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 157.3628 627.1174 Tm (T)Tj 0.38 0.38 0.372 rg 0.009 Tc 0.646 0 Td (ashkin )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf -0.0276 Tc 8.9 0 0 8.9 191.0048 627.1174 Tm (DP, )Tj EMC ET BT /T1_0 1 Tf 0.0204 Tc 8.9 0 0 8.9 207.7635 627.1174 Tm (Trevor )Tj -0.035 Tc 8.8654 0 0 8.9 237.07 627.12 Tm (E, )Tj -0.0125 Tc 8.9 0 0 8.9 248.59 627.12 Tm (Elan )Tj -0.035 Tc 8.8653 0 0 8.9 268.76 627.12 Tm (D. )Tj 0.525 0.525 0.514 rg 0 Tc 8.9 0 0 8.9 47.42 617.53 Tm (-)Tj 0.247 0.251 0.243 rg 1.083 0 Td (I)Tj 0.38 0.38 0.372 rg -0.0053 Tc 0.382 0 Td (maging )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.006 Tc 8.9 0 0 8.9 92.0268 617.53 Tm (sites )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.4598 0 0 8.9 112.71 617.53 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0461 Tc 8.9 0 0 8.9 124.71 617.53 Tm (ai)Tj 0.247 0.251 0.243 rg 0 Tc 0.764 0 Td (r)Tj 0.38 0.38 0.372 rg 0.0057 Tc 0.324 0 Td (way )Tj EMC /Suspect <>BDC 0.0017 Tc 2.203 0 Td (obstructio)Tj 0.247 0.251 0.243 rg 0 Tc 3.999 0 Td (n )Tj EMC ET BT /T1_0 1 Tf 0.0121 Tc 8.9 0 0 8.9 199.114 617.53 Tm (and )Tj -0.0006 Tc 1.949 0 Td (measuring )Tj -0.0062 Tc 4.737 0 Td (func\255)Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf -0.0121 Tc 8.9 0 0 8.9 48.4637 607.4374 Tm (tional )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 72.9565 607.4374 Tm (r)Tj 0.38 0.38 0.372 rg 0.0038 Tc 0.315 0 Td (esponses )Tj 0.247 0.251 0.243 rg 0 Tc 4.107 0 Td (t)Tj 0.38 0.38 0.372 rg 0.209 0 Td (o )Tj 0.318 0.318 0.31 rg 0.0046 Tc 0.981 0 Td (bronchodilator )Tj 0.247 0.251 0.243 rg -0.0144 Tc 6.415 0 Td (tr)Tj 0.38 0.38 0.372 rg 0 Tc 0.585 0 Td (e)Tj 0.247 0.251 0.243 rg 0.0197 Tc 0.431 0 Td (atment )Tj 0.0481 Tc 3.238 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0081 Tc 8.9 0 0 8.9 228.8756 607.4374 Tm (asthma)Tj 0.38 0.38 0.372 rg 0 Tc 2.848 0 Td (. )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg /T1_2 1 Tf -0.0274 Tc 9 0 0 9 259.98 607.44 Tm (Tho\255)Tj EMC /Suspect <>BDC -0.0114 Tc -23.559 -1.12 Td (rax, )Tj EMC ET BT /T1_0 1 Tf -0.0053 Tc 8.9 0 0 8.9 65.93 597.36 Tm (1979, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0137 Tc 8.9 0 0 8.9 89.1768 597.36 Tm (34, )Tj EMC ET BT /T1_0 1 Tf 0.0127 Tc 8.9 0 0 8.9 103.6393 597.36 Tm (493)Tj 0.38 0.38 0.372 rg 0 Tc 1.557 0 Td (-)Tj 0.247 0.251 0.243 rg 0.0213 Tc 0.483 0 Td (500. )Tj 0.0204 Tc -8.351 -1.079 Td (4. )Tj 0.0086 Tc 1.564 0 Td (Despas )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.893 0 0 8.9 91.16 587.76 Tm (P, )Tj EMC ET BT /T1_0 1 Tf 0.0176 Tc 8.9 0 0 8.9 101.73 587.76 Tm (Walker )Tj -0.035 Tc 8.763 0 0 8.9 131.5 587.76 Tm (A, )Tj 0.0163 Tc 8.9 0 0 8.9 143.48 587.76 Tm (MacRae )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.8613 0 0 8.9 177.07 587.76 Tm (J, )Tj EMC ET BT /T1_0 1 Tf -0.0001 Tc 8.9 0 0 8.9 186.2 587.76 Tm (Read )Tj -0.035 Tc 9.6669 0 0 10 207.79 587.76 Tm (J.)Tj 0.38 0.38 0.372 rg 0 Tc 10 0 0 10 216.84 587.76 Tm (-)Tj 0.247 0.251 0.243 rg 0.0011 Tc 8.9 0 0 8.9 225.06 587.76 Tm (Inhalation )Tj -0.0148 Tc 4.473 0 Td (and )Tj 0.0012 Tc -24.42 -1.133 Td (perfusion )Tj -0.012 Tc 4.144 0 Td (lung )Tj 0.318 0.318 0.31 rg 0.0046 Tc 2.097 0 Td (scans )Tj 0.247 0.251 0.243 rg 0.05 Tc 9.4716 0 0 8.9 125.2 577.68 Tm (in )Tj -0.0053 Tc 8.9 0 0 8.9 135.85 577.68 Tm (bronchial )Tj -0.0169 Tc 4.088 0 Td (asthma. )Tj /T1_2 1 Tf 0.05 Tc 9.0326 0 0 8.8 201.74 577.68 Tm (Aus )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0428 Tc 8.8 0 0 8.8 218.53 577.68 Tm (Ann )Tj EMC ET BT /T1_2 1 Tf -0.0306 Tc 9 0 0 9 236.25 577.68 Tm (Med, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0188 Tc 8.9 0 0 8.9 257.93 577.68 Tm (1970, )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0204 Tc 8.9 0 0 8.9 47.4806 568.0858 Tm (4, )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf 0.0404 Tc 8.9 0 0 8.9 57.502 568.0858 Tm (304-309. )Tj EMC ET BT /T1_2 1 Tf -0.0103 Tc 9.3 0 0 9.3 47.43 558 Tm (5. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0036 Tc 8.9 0 0 8.9 62.84 558 Tm (Ruffin )Tj EMC ET BT /T1_0 1 Tf -0.0068 Tc 8.9 0 0 8.9 90.1986 558 Tm (RE, )Tj 0.0027 Tc 2.049 0 Td (Dolovich )Tj -0.0073 Tc 4.207 0 Td (MB, )Tj 0.0254 Tc 2.266 0 Td (Wolff )Tj -0.0089 Tc 2.911 0 Td (RK, )Tj 0.0059 Tc 2.112 0 Td (Newhouse )Tj 0.0207 Tc 4.683 0 Td (MT. )Tj 0.318 0.318 0.31 rg 0 Tc 2.204 0 Td (-)Tj 0.05 Tc 9.0924 0 0 8.9 46.96 547.92 Tm (The )Tj 0.38 0.38 0.372 rg 0.0092 Tc 8.9 0 0 8.9 67.11 547.92 Tm (effects )Tj 0.05 Tc 10.0163 0 0 8.9 96.38 547.92 Tm (of )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0008 Tc 8.9 0 0 8.9 109.93 547.92 Tm (preferential )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0149 Tc 8.9 0 0 8.9 156.8775 547.92 Tm (deposit)Tj 0.247 0.251 0.243 rg 0.0168 Tc 2.967 0 Td (ion )Tj 0.05 Tc 9.4598 0 0 8.9 200.07 547.92 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0072 Tc 8.9 0 0 8.9 213.11 547.92 Tm (histamine )Tj EMC ET BT /T1_0 1 Tf 0.0481 Tc 8.9 0 0 8.9 253.3736 547.92 Tm (in )Tj 0.0114 Tc 1.462 0 Td (the )Tj 0.38 0.38 0.372 rg 0.0086 Tc -24.592 -1.131 Td (human )Tj -0.0074 Tc 3.173 0 Td (airway. )Tj 0.247 0.251 0.243 rg /T1_2 1 Tf 0.05 Tc 9.4102 0 0 8.8 105.26 537.85 Tm (Am )Tj 0 Tc 9 0 0 9 121.51 537.85 Tm (R)Tj 0.38 0.38 0.372 rg 0.0341 Tc 0.57 0 Td (ev )Tj 0.318 0.318 0.31 rg 0.0017 Tc 1.297 0 Td (Respir )Tj -0.0317 Tc 2.989 0 Td (Dis, )Tj 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0138 Tc 8.9 0 0 8.9 183.05 537.85 Tm (197)Tj 0.247 0.251 0.243 rg -0.0138 Tc 1.527 0 Td (8, )Tj -0.0022 Tc 1.17 0 Td (117, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0374 Tc 8.9 0 0 8.9 225.0847 537.85 Tm (485-492. )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf -0.0243 Tc 8.9 0 0 8.9 47.414 528.238 Tm (6. )Tj 0.0131 Tc 1.728 0 Td (Chung )Tj 0.247 0.251 0.243 rg 0.0185 Tc 3.296 0 Td (KF)Tj 0.38 0.38 0.372 rg 0 Tc 1.175 0 Td (, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0294 Tc 8.9 0 0 8.9 109.2868 528.238 Tm (Snas)Tj 0.247 0.251 0.243 rg 0 Tc 2.012 0 Td (h)Tj 0.38 0.38 0.372 rg -0.0345 Tc 0.476 0 Td (all )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg 0 Tc 1.462 0 Td (P)Tj 0.38 0.38 0.372 rg -0.035 Tc 8.3438 0 0 8.9 150.2 528.24 Tm (D. )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 162.62 528.24 Tm (-)Tj 0.247 0.251 0.243 rg 1.03 0 Td (E)Tj 0.38 0.38 0.372 rg -0.0036 Tc 0.588 0 Td (ffect )Tj 0.247 0.251 0.243 rg 0.05 Tc 9.4598 0 0 8.9 197.67 528.24 Tm (of )Tj 0.0289 Tc 8.9 0 0 8.9 209.29 528.24 Tm (prior )Tj 0.0081 Tc 2.481 0 Td (bronchocon\255)Tj 0.38 0.38 0.372 rg 0.0053 Tc -20.672 -1.131 Td (striction )Tj 0 Tc 3.997 0 Td (o)Tj 0.247 0.251 0.243 rg 0.547 0 Td (n )Tj 0.318 0.318 0.31 rg 0.0114 Tc 1.239 0 Td (the )Tj 0.0087 Tc 1.88 0 Td (airway )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.009 Tc 8.9 0 0 8.9 146.3937 518.1741 Tm (response )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.4365 0 0 8.9 184.3 518.17 Tm (to )Tj 0.247 0.251 0.243 rg 0.014 Tc 8.9 0 0 8.9 197.27 518.17 Tm (histamine )Tj /T1_1 1 Tf 0.05 Tc 9.7493 0 0 8.8 237.89 518.17 Tm (in )Tj /T1_0 1 Tf 0.0171 Tc 8.9 0 0 8.9 251.03 518.17 Tm (normal )Tj 0.318 0.318 0.31 rg 0.0011 Tc -22.881 -1.133 Td (subjects. )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_2 1 Tf 0.0003 Tc 9 0 0 9 81.42 508.09 Tm (Thorax, )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0082 Tc 8.9 0 0 8.9 113.93 508.09 Tm (1984, )Tj 0.0137 Tc 2.612 0 Td (39, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0474 Tc 8.9 0 0 8.9 151.6393 508.09 Tm (40-45. )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf 0.0297 Tc 8.9 0 0 8.9 46.9486 497.9974 Tm (7. )Tj 0.318 0.318 0.31 rg 0.0131 Tc 1.78 0 Td (Chung )Tj 0.247 0.251 0.243 rg -0.0348 Tc 3.242 0 Td (KF, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0068 Tc 8.9 0 0 8.9 109.7648 497.9974 Tm (Snashall )Tj EMC /Suspect <>BDC -0.0013 Tc 3.951 0 Td (PD. )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 162.6308 497.9974 Tm (-)Tj 0.247 0.251 0.243 rg 0.0067 Tc 1.031 0 Td (Methacholine )Tj 0.0215 Tc 6.036 0 Td (dose)Tj 0.38 0.38 0.372 rg 0 Tc 1.885 0 Td (-)Tj 0.247 0.251 0.243 rg 0.0013 Tc 0.334 0 Td (response )Tj 0.011 Tc -22.283 -1.078 Td (curves )Tj -0.0058 Tc 3.13 0 Td (in )Tj 0.0171 Tc 1.193 0 Td (normal )Tj 0.0121 Tc 3.389 0 Td (and )Tj 0.0085 Tc 1.942 0 Td (asthmatic )Tj 0.001 Tc 4.322 0 Td (man: )Tj 0.0134 Tc 2.473 0 Td (effect )Tj 0.05 Tc 8.9033 0 0 8.9 218.32 488.41 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0148 Tc 8.9 0 0 8.9 229.31 488.41 Tm (starting )Tj EMC ET BT /T1_0 1 Tf 0.0079 Tc 8.9 0 0 8.9 260.549 488.41 Tm (con\255)Tj 0.0028 Tc -23.999 -1.133 Td (ductance )Tj -0.0148 Tc 3.99 0 Td (and )Tj 0.0029 Tc 1.791 0 Td (pharmacological )Tj -0.0045 Tc 7.054 0 Td (antagonism. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0013 Tc 9 0 0 9 207.66 478.33 Tm (Clin )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_2 1 Tf -0.0135 Tc 9 0 0 9 226.074 478.33 Tm (Sci, )Tj /T1_0 1 Tf -0.0053 Tc 8.9 0 0 8.9 243.05 478.33 Tm (1984, )Tj 0.247 0.251 0.243 rg -0.0194 Tc 2.611 0 Td (66, )Tj 0.318 0.318 0.31 rg 0.031 Tc -24.647 -1.08 Td (665-673. )Tj 0.247 0.251 0.243 rg -0.0138 Tc -0.006 -1.131 Td (8. )Tj 0.0169 Tc 1.955 0 Td (Ryan )Tj -0.035 Tc 8.8509 0 0 8.9 88.71 458.65 Tm (G, )Tj 0 Tc 8.9 0 0 8.9 102.68 458.65 Tm (D)Tj 0.38 0.38 0.372 rg 0.751 0 Td (o)Tj 0.247 0.251 0.243 rg 0.487 0 Td (l)Tj 0.38 0.38 0.372 rg 0.0267 Tc 0.269 0 Td (ovic)Tj 0.247 0.251 0.243 rg 0 Tc 1.788 0 Td (h )Tj -0.0343 Tc 1.129 0 Td (MB, )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0025 Tc 8.9 0 0 8.9 163.1199 458.65 Tm (Obminski )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf -0.035 Tc 8.8509 0 0 8.9 203.91 458.65 Tm (G, )Tj 0.0224 Tc 8.9 0 0 8.9 217.83 458.65 Tm (Cockcroft )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf -0.0295 Tc 8.9 0 0 8.9 259.5888 458.65 Tm (OW, )Tj EMC ET BT /T1_0 1 Tf 0.0144 Tc 8.9 0 0 8.9 46.9856 448.5574 Tm (Juniper )Tj -0.035 Tc 8.2744 0 0 8.9 78.19 448.56 Tm (E, )Tj 0 Tc 8.9 0 0 8.9 90.2 448.56 Tm (H)Tj 0.38 0.38 0.372 rg -0.0122 Tc 0.749 0 Td (arg)Tj 0.247 0.251 0.243 rg 0 Tc 1.249 0 Td (r)Tj 0.38 0.38 0.372 rg 0.0261 Tc 0.315 0 Td (eave )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0262 Tc 8.9 0 0 8.9 132.4394 448.56 Tm (PE, )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 149.8033 448.56 Tm (N)Tj 0.38 0.38 0.372 rg 0.0047 Tc 0.687 0 Td (ewhouse )Tj 0.247 0.251 0.243 rg -0.0323 Tc 4.051 0 Td (MT)Tj 0.38 0.38 0.372 rg 0 Tc 1.494 0 Td (. )Tj 0.525 0.525 0.514 rg 0.656 0 Td (-)Tj 0.38 0.38 0.372 rg -0.0005 Tc 1.072 0 Td (Sta)Tj 0.247 0.251 0.243 rg 0 Tc 1.311 0 Td (n)Tj 0.38 0.38 0.372 rg 0.0119 Tc 0.478 0 Td (dardisat)Tj 0.247 0.251 0.243 rg 0 Tc 3.237 0 Td (i)Tj 0.38 0.38 0.372 rg -0.035 Tc 8.6386 0 0 8.9 267.76 448.56 Tm (on )Tj 0.247 0.251 0.243 rg 0.05 Tc 10.0163 0 0 8.9 46.46 438.97 Tm (of )Tj 0.0075 Tc 8.9 0 0 8.9 58.01 438.97 Tm (inhalation )Tj 0.318 0.318 0.31 rg 0.0123 Tc 4.431 0 Td (provo)Tj 0.463 0.463 0.455 rg 0.05 Tc 8.9089 0 0 8.9 118.47 438.97 Tm (ca)Tj 0.318 0.318 0.31 rg -0.0138 Tc 8.9 0 0 8.9 127.18 438.97 Tm (tion )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0108 Tc 8.9 0 0 8.9 144.4638 438.97 Tm (tests: )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0188 Tc 8.9 0 0 8.9 166.4913 438.97 Tm (innuence )Tj 0.05 Tc 9.4598 0 0 8.9 202.95 438.97 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0272 Tc 8.9 0 0 8.9 214.55 438.97 Tm (nebuli7.er )Tj EMC /Suspect <>BDC 0.0035 Tc 4.091 0 Td (output, )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0129 Tc 8.9 0 0 8.9 46.5714 428.8863 Tm (particle )Tj 0.247 0.251 0.243 rg 0.0008 Tc 3.436 0 Td (size, )Tj 0.318 0.318 0.31 rg -0.035 Tc 8.811 0 0 8.9 97.35 428.89 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0053 Tc 8.9 0 0 8.9 113.74 428.89 Tm (method )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.05 Tc 10.0163 0 0 8.9 143.9 428.89 Tm (of )Tj 0.318 0.318 0.31 rg -0.0021 Tc 8.9 0 0 8.9 155.45 428.89 Tm (inhalation. )Tj 0.247 0.251 0.243 rg /T1_3 1 Tf 0 Tc 8.7 0 0 8.7 195.76 428.89 Tm (J )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_2 1 Tf 0.0087 Tc 9 0 0 9 203.66 428.89 Tm (Allergy )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_2 1 Tf -0.0013 Tc 9 0 0 9 234.062 428.89 Tm (C/in )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_2 1 Tf 0.0069 Tc 8.6 0 0 8.6 253.05 428.89 Tm (/mmtl)Tj 0.463 0.463 0.455 rg 0 Tc 2.424 0 Td (\267 )Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg 9 0 0 9 46.51 418.81 Tm (n)Tj 0.463 0.463 0.455 rg 0.0431 Tc 0.531 0 Td (ol)Tj 0.318 0.318 0.31 rg 0 Tc 0.811 0 Td (, )Tj EMC ET BT /T1_0 1 Tf -0.0188 Tc 8.9 0 0 8.9 64.49 418.81 Tm (1981. )Tj 0.38 0.38 0.372 rg -0.0194 Tc 2.611 0 Td (67, )Tj 0.247 0.251 0.243 rg 0 Tc 1.757 0 Td (1)Tj 0.38 0.38 0.372 rg 0.05 Tc 8.9782 0 0 8.9 106.44 418.81 Tm (56)Tj 0.525 0.525 0.514 rg 0 Tc 8.9 0 0 8.9 115.58 418.81 Tm (-)Tj 0.318 0.318 0.31 rg -0.0022 Tc 0.57 0 Td (161. )Tj 0.38 0.38 0.372 rg -0.024 Tc -8.336 -1.134 Td (9. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.8415 0 0 8.9 65.19 408.72 Tm (Chatl1arn )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf 0.0041 Tc 8.9 0 0 8.9 103.64 408.72 Tm (M. )Tj -0.0045 Tc 1.834 0 Td (Bl)Tj 0.38 0.38 0.372 rg 0.0172 Tc 0.911 0 Td (ecker )Tj 0.318 0.318 0.31 rg -0.0285 Tc 2.917 0 Td (ER, )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0051 Tc 8.9 0 0 8.9 173.1223 408.72 Tm (Smith )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf -0.0338 Tc 8.9 0 0 8.9 201.0861 408.72 Tm (RL. )Tj 0 Tc 2.211 0 Td (R)Tj 0.38 0.38 0.372 rg 0.0184 Tc 0.589 0 Td (osc)Tj 0.247 0.251 0.243 rg -0.035 Tc 8.4745 0 0 8.9 238.07 408.72 Tm (ntl1al )Tj -0.0348 Tc 8.9 0 0 8.9 262.52 408.72 Tm (RR. )Tj 0 Tc -24.27 -1.079 Td (M)Tj 0.38 0.38 0.372 rg -0.0133 Tc 0.911 0 Td (aso)Tj 0.247 0.251 0.243 rg 0 Tc 1.357 0 Td (n )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf -0.035 Tc 8.893 0 0 8.9 75.32 399.12 Tm (P. )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 86.92 399.12 Tm (N)Tj 0.38 0.38 0.372 rg 0.688 0 Td (o)Tj 0.247 0.251 0.243 rg -0.031 Tc 0.547 0 Td (rm)Tj 0.38 0.38 0.372 rg -0.0151 Tc 1.124 0 Td (an )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf -0.035 Tc 8.1383 0 0 8.9 120.92 399.12 Tm (PS)Tj 0.38 0.38 0.372 rg 0 Tc 8.9 0 0 8.9 130.38 399.12 Tm (. )Tj EMC ET BT 0.525 0.525 0.514 rg /T1_0 1 Tf 8.9 0 0 8.9 136.2184 399.12 Tm (-)Tj 0.247 0.251 0.243 rg 1.088 0 Td (A )Tj 0.38 0.38 0.372 rg 0.0056 Tc 1.125 0 Td (comparison )Tj 0.05 Tc 9.4598 0 0 8.9 201.99 399.12 Tm (of )Tj 0.318 0.318 0.31 rg -0.0034 Tc 8.9 0 0 8.9 214.07 399.12 Tm (histamine, )Tj -0.017 Tc 4.691 0 Td (meth)Tj 0.525 0.525 0.514 rg 0 Tc 1.987 0 Td (\255)Tj 0.38 0.38 0.372 rg 0.0191 Tc -25.509 -1.131 Td (acholine )Tj 0.318 0.318 0.31 rg 0.0121 Tc 4.315 0 Td (and )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.018 Tc 8.9 0 0 8.9 105.0361 389.0541 Tm (exe)Tj 0.247 0.251 0.243 rg 0 Tc 1.411 0 Td (r)Tj 0.38 0.38 0.372 rg 0.0287 Tc 0.369 0 Td (cise )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0087 Tc 8.9 0 0 8.9 142.4784 389.0541 Tm (airway )Tj 0.247 0.251 0.243 rg 0 Tc 3.569 0 Td (r)Tj 0.38 0.38 0.372 rg 0.0178 Tc 0.315 0 Td (eactivity )Tj 0.247 0.251 0.243 rg -0.035 Tc 8.5969 0 0 8.9 216.41 389.05 Tm (in )Tj 0 Tc 8.9 0 0 8.9 230.39 389.05 Tm (n)Tj 0.38 0.38 0.372 rg 0.0423 Tc 0.478 0 Td (onna)Tj 0.247 0.251 0.243 rg 0 Tc 2.053 0 Td (J )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0148 Tc 8.9 0 0 8.9 263.4357 389.05 Tm (and )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0081 Tc 8.9 0 0 8.9 46.4715 379.438 Tm (asthma)Tj 0.247 0.251 0.243 rg -0.0123 Tc 2.866 0 Td (ti)Tj 0.38 0.38 0.372 rg 0 Tc (c )Tj 0.0079 Tc 1.39 0 Td (subjects. )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_2 1 Tf 0.05 Tc 9.0617 0 0 8.8 118.7 379.44 Tm (Am )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg 0 Tc 9 0 0 9 134.95 379.44 Tm (R)Tj 0.38 0.38 0.372 rg 0.0341 Tc 0.57 0 Td (ev )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg 0 Tc 1.297 0 Td (R)Tj 0.38 0.38 0.372 rg 0.05 Tc 10.1565 0 0 9 156.88 379.44 Tm (opir )Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg -0.0025 Tc 9 0 0 9 178.65 379.44 Tm (Dis)Tj 0.463 0.463 0.455 rg 0 Tc 1.327 0 Td (, )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf 8.6 0 0 8.6 197.23 379.44 Tm (J )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0175 Tc 8.9 0 0 8.9 201.02 379.44 Tm (982)Tj 0.247 0.251 0.243 rg 0 Tc 1.56 0 Td (, )Tj EMC /Suspect <>BDC -0.035 Tc 8.5945 0 0 8.9 220.98 379.44 Tm (12)Tj 0.38 0.38 0.372 rg -0.0243 Tc 8.9 0 0 8.9 229.33 379.44 Tm (6, )Tj EMC /Suspect <>BDC 0.0225 Tc 1.139 0 Td (235-240. )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg 0 Tc -21.574 -1.131 Td (I )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg -0.0273 Tc 0.374 0 Td (0. )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.005 Tc 8.9 0 0 8.9 64.7779 369.3741 Tm (Vernon )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf -0.035 Tc 8.2578 0 0 8.9 95.48 369.37 Tm (P. )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg 0.0114 Tc 8.9 0 0 8.9 105.44 369.37 Tm (Seed )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 126.6932 369.37 Tm (W )Tj 0.318 0.318 0.31 rg /T1_1 1 Tf 0.05 Tc 8.2091 0 0 8.1 135.37 369.37 Tm (A. )Tj 0.525 0.525 0.514 rg 0 Tc 8.1 0 0 8.1 147.29 369.37 Tm (-)Tj 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0107 Tc 8.9 0 0 8.9 154.95 369.37 Tm (Quanti )Tj 0.38 0.38 0.372 rg -0.0119 Tc 2.812 0 Td (tat )Tj 0.318 0.318 0.31 rg -0.0102 Tc 1.019 0 Td (ion )Tj 0.38 0.38 0.372 rg 0.05 Tc 9.4598 0 0 8.9 203.91 369.37 Tm (of )Tj 0.318 0.318 0.31 rg 0.0122 Tc 8.9 0 0 8.9 214.48 369.37 Tm (diagnostic )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0125 Tc 8.9 0 0 8.9 255.3399 369.37 Tm (venti)Tj 0.525 0.525 0.514 rg 0 Tc 2.04 0 Td (\255)Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf -0.0095 Tc 8.9 0 0 8.9 46.4836 359.758 Tm (lation )Tj 0.318 0.318 0.31 rg -0.0148 Tc 2.91 0 Td (and )Tj 0.0079 Tc 2.061 0 Td (perfusion )Tj 0.247 0.251 0.243 rg -0.0107 Tc 4.467 0 Td (lun)Tj 0.38 0.38 0.372 rg 0 Tc 1.24 0 Td (g )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0076 Tc 8.9 0 0 8.9 151.0586 359.758 Tm (scans. )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg /T1_2 1 Tf -0.035 Tc 8.642 0 0 9 178.5 359.76 Tm (br)Tj 0.463 0.463 0.455 rg 0 Tc 9 0 0 9 186.08 359.76 Tm (: )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_2 1 Tf 0.0137 Tc 9 0 0 9 194.468 359.76 Tm (Br )Tj 0.318 0.318 0.31 rg 0 Tc 9.6 0 0 9.6 208.42 359.76 Tm (J )Tj 0.247 0.251 0.243 rg 0.0129 Tc 9 0 0 9 217.99 359.76 Tm (Ra)Tj 0.38 0.38 0.372 rg -0.0067 Tc 1.107 0 Td (dio)Tj 0.247 0.251 0.243 rg 0 Tc 1.35 0 Td (/)Tj 0.38 0.38 0.372 rg 0.246 0 Td (. )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0077 Tc 8.9 0 0 8.9 249.92 359.76 Tm (Special )Tj EMC /Suspect <>BDC -0.035 Tc 8.7223 0 0 8.9 46.52 349.69 Tm (Report., )Tj EMC /Suspect <>BDC 0 Tc 8.9 0 0 8.9 76.27 349.69 Tm (J)Tj 0.463 0.463 0.455 rg 0.417 0 Td (.)Tj 0.318 0.318 0.31 rg 0.231 0 Td (P)Tj 0.525 0.525 0.514 rg 0.578 0 Td (. )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf -0.0153 Tc 8.9 0 0 8.9 93.0732 349.69 Tm (Lav)Tj 0.38 0.38 0.372 rg 0.0165 Tc 1.56 0 Td (ender )Tj 0.011 Tc 2.589 0 Td (ed., )Tj -0.0053 Tc 1.971 0 Td (1978, )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf -0.035 Tc 8.6596 0 0 8.9 171.54 349.69 Tm (15, )Tj EMC ET BT /T1_0 1 Tf -0.0003 Tc 8.9 0 0 8.9 185.29 349.69 Tm (pp. )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 200.8116 349.69 Tm (1)Tj 0.38 0.38 0.372 rg 0.05 Tc 9.5225 0 0 8.9 204.38 349.69 Tm (04-)Tj 0.247 0.251 0.243 rg 0 Tc 8.9 0 0 8.9 218.57 349.69 Tm (1)Tj 0.38 0.38 0.372 rg 0.006 Tc 0.402 0 Td (07. )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 46.5063 340.0869 Tm (J )Tj 0.05 Tc 10.2537 0 0 8.9 51.27 340.09 Tm (l. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0158 Tc 8.9 0 0 8.9 66.19 340.09 Tm (Ellen )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf -0.0103 Tc 8.9 0 0 8.9 89.2499 340.09 Tm (WH, )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0123 Tc 8.9 0 0 8.9 110.7879 340.09 Tm (Callahan )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0341 Tc 8.9 0 0 8.9 147.8208 340.09 Tm (AB, )Tj 0.0026 Tc 2.047 0 Td (Brainwell )Tj -0.0015 Tc 4.471 0 Td (GL. )Tj 0.38 0.38 0.372 rg 0 Tc 2.048 0 Td (-)Tj 0.318 0.318 0.31 rg 0.0088 Tc 1.026 0 Td (Gamma)Tj 0.525 0.525 0.514 rg 0 Tc 3.181 0 Td (-)Tj 0.247 0.251 0.243 rg 0.334 0 Td (r)Tj 0.38 0.38 0.372 rg -0.0151 Tc 0.369 0 Td (ay )Tj 0.318 0.318 0.31 rg 0.0005 Tc -24.916 -1.134 Td (dosimetry )Tj 0.38 0.38 0.372 rg 0.05 Tc 10.0163 0 0 8.9 84.86 330 Tm (of )Tj 0.318 0.318 0.31 rg -0.0019 Tc 8.9 0 0 8.9 96.41 330 Tm (internal )Tj 0.38 0.38 0.372 rg -0.0105 Tc 3.449 0 Td (emi)Tj 0.247 0.251 0.243 rg -0.0123 Tc 1.572 0 Td (tt)Tj 0.38 0.38 0.372 rg 0.0023 Tc 0.478 0 Td (ers. )Tj 0.247 0.251 0.243 rg 0.05 Tc 8.9682 0 0 8.9 161.68 330 Tm (ll)Tj 0.38 0.38 0.372 rg 0 Tc 8.9 0 0 8.9 167.82 330 Tm (. )Tj 0.247 0.251 0.243 rg 0.609 0 Td (M)Tj 0.38 0.38 0.372 rg 0.858 0 Td (o)Tj 0.247 0.251 0.243 rg 0.05 Tc 9.3238 0 0 8.9 185.27 330 Tm (nt)Tj 0.38 0.38 0.372 rg 0 Tc 8.9 0 0 8.9 192.39 330 Tm (e )Tj 0.318 0.318 0.31 rg 0.0035 Tc 0.863 0 Td (Carlo )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0095 Tc 8.9 0 0 8.9 222.6322 330 Tm (calculations )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 269.2059 330 Tm (o)Tj 0.247 0.251 0.243 rg 0.537 0 Td (f )Tj 0.38 0.38 0.372 rg 0.0024 Tc -25.617 -1.078 Td (absorbed )Tj 0.318 0.318 0.31 rg 0.0215 Tc 4.046 0 Td (dose )Tj -0.0249 Tc 2.371 0 Td (from )Tj 0.0117 Tc 2.33 0 Td (uniform )Tj 0.38 0.38 0.372 rg 0.0097 Tc 3.707 0 Td (sources. )Tj 0.247 0.251 0.243 rg /T1_2 1 Tf 0.0137 Tc 9 0 0 9 190.15 320.41 Tm (Br )Tj 0.318 0.318 0.31 rg /T1_3 1 Tf 0 Tc 8.6 0 0 8.6 202.48 320.41 Tm (J )Tj 0.247 0.251 0.243 rg /T1_2 1 Tf 9 0 0 9 210.79 320.41 Tm (R)Tj 0.38 0.38 0.372 rg 0.0151 Tc 0.572 0 Td (adio)Tj 0.247 0.251 0.243 rg 0 Tc 1.831 0 Td (/)Tj 0.38 0.38 0.372 rg 0.312 0 Td (, )Tj 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0188 Tc 8.9 0 0 8.9 241.61 320.41 Tm (1965. )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0077 Tc 8.9 0 0 8.9 264.3762 320.41 Tm (38)Tj 0.247 0.251 0.243 rg 0 Tc 1.074 0 Td (, )Tj EMC ET BT /T1_0 1 Tf 0.0246 Tc 8.9 0 0 8.9 45.9524 310.3263 Tm (541-545. )Tj -0.023 Tc 0.033 -1.133 Td (12. )Tj 0.0127 Tc 2.134 0 Td (Roedler )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0303 Tc 8.9 0 0 8.9 98.3556 300.2426 Tm (HS, )Tj EMC ET BT /T1_0 1 Tf 0.0006 Tc 8.9 0 0 8.9 116.12 300.2426 Tm (Kaul )Tj -0.035 Tc 8.2476 0 0 8.9 138.23 300.25 Tm (A, )Tj 0.0036 Tc 8.9 0 0 8.9 150.68 300.25 Tm (Hine )Tj 0.0281 Tc 2.367 0 Td (GJ. )Tj 0.318 0.318 0.31 rg 0 Tc 1.887 0 Td (-)Tj 0.247 0.251 0.243 rg /T1_2 1 Tf -0.035 Tc 8.94 0 0 9 197.37 300.25 Tm (In: )Tj /T1_0 1 Tf 0.013 Tc 8.9 0 0 8.9 211.62 300.25 Tm (Internal )Tj 0.008 Tc 3.619 0 Td (radiation )Tj 0.0215 Tc -22.282 -1.079 Td (dose )Tj -0.0058 Tc 2.266 0 Td (in )Tj 0.0122 Tc 1.131 0 Td (diagnostic )Tj 0.0215 Tc 4.598 0 Td (Nuclear )Tj 0.0042 Tc 3.604 0 Td (Medicine, )Tj 0.0261 Tc 4.47 0 Td (3rd )Tj 0.0175 Tc 1.727 0 Td (edn. )Tj 0.0099 Tc 2.109 0 Td (H. )Tj -0.003 Tc 1.404 0 Td (Varlag )Tj -0.007 Tc 3.12 0 Td (ed., )Tj -0.0243 Tc -24.426 -1.079 Td (Ho)Tj 0.38 0.38 0.372 rg 0.05 Tc 9.7933 0 0 8.9 56.05 281.05 Tm (ff)Tj 0.247 0.251 0.243 rg 0.0051 Tc 8.9 0 0 8.9 62.38 281.05 Tm (man)Tj 0.38 0.38 0.372 rg 0 Tc 1.766 0 Td (, )Tj -0.0053 Tc 0.736 0 Td (1978. )Tj 0.318 0.318 0.31 rg 0.004 Tc -4.369 -1.133 Td (13. )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf -0.0116 Tc 8.9 0 0 8.9 63.7951 270.9663 Tm (Pavi)Tj 0.38 0.38 0.372 rg 0 Tc 1.828 0 Td (a )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0153 Tc 8.9 0 0 8.9 87.3178 270.9663 Tm (D, )Tj 0.0206 Tc 1.344 0 Td (Thomson )Tj 0.247 0.251 0.243 rg -0.0063 Tc 4.319 0 Td (ML, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0112 Tc 8.9 0 0 8.9 156.8713 270.9663 Tm (Clarke )Tj EMC /Suspect <>BDC -0.0213 Tc 3.12 0 Td (SW, )Tj EMC /Suspect <>BDC 0.0069 Tc 2.157 0 Td (Shannon )Tj EMC /Suspect <>BDC -0.0034 Tc 3.951 0 Td (HS. )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 255.7414 270.9663 Tm (-)Tj -0.0114 Tc 0.976 0 Td (Ef\255)Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0163 Tc 8.9 0 0 8.9 45.4967 260.8826 Tm (fecl )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.05 Tc 10.0163 0 0 8.9 62.78 260.89 Tm (of )Tj 0.247 0.251 0.243 rg -0.0107 Tc 8.9 0 0 8.9 74.81 260.89 Tm (lun)Tj 0.38 0.38 0.372 rg 0 Tc 1.294 0 Td (g )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf -0.0289 Tc 8.9 0 0 8.9 94.9329 260.89 Tm (fun)Tj 0.38 0.38 0.372 rg 0.0046 Tc 1.349 0 Td (ction )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0121 Tc 8.9 0 0 8.9 129.0199 260.89 Tm (and )Tj 0.247 0.251 0.243 rg 0.0165 Tc 1.949 0 Td (mode )Tj 0.318 0.318 0.31 rg 0.05 Tc 9.4598 0 0 8.9 170.31 260.89 Tm (of )Tj 0.247 0.251 0.243 rg 0.0015 Tc 8.9 0 0 8.9 182.33 260.89 Tm (inhalation )Tj 0.0451 Tc 4.475 0 Td (on )Tj 0.0046 Tc 1.466 0 Td (penetration )Tj 0.05 Tc 10.0163 0 0 8.9 45.02 251.29 Tm (of )Tj 0.38 0.38 0.372 rg -0.0016 Tc 8.9 0 0 8.9 56.55 251.29 Tm (aeroso)Tj 0.247 0.251 0.243 rg 0 Tc 2.645 0 Td (l )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0092 Tc 8.9 0 0 8.9 86.3294 251.29 Tm (into )Tj EMC /Suspect <>BDC 0.0114 Tc 1.947 0 Td (the )Tj EMC ET BT /T1_0 1 Tf -0.0049 Tc 8.9 0 0 8.9 118.0691 251.29 Tm (human )Tj 0.247 0.251 0.243 rg 0.006 Tc 3.121 0 Td (lung)Tj 0.38 0.38 0.372 rg 0 Tc 1.875 0 Td (. )Tj 0.247 0.251 0.243 rg /T1_2 1 Tf -0.0085 Tc 9 0 0 9 167.34 251.29 Tm (Thorax, )Tj /T1_0 1 Tf -0.0053 Tc 8.9 0 0 8.9 199.85 251.29 Tm (1977, )Tj 0.0137 Tc 2.612 0 Td (32, )Tj 0.0223 Tc 1.702 0 Td (194-197. )Tj -0.023 Tc -21.627 -1.133 Td (14. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0154 Tc 8.9 0 0 8.9 65.2375 241.2063 Tm (Pavia )Tj EMC ET BT /T1_0 1 Tf 0.0153 Tc 8.9 0 0 8.9 89.2408 241.2063 Tm (D, )Tj 0.0206 Tc 1.398 0 Td (Thomson )Tj 0.0041 Tc 4.427 0 Td (M, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0069 Tc 8.9 0 0 8.9 155.3589 241.2063 Tm (Shannon )Tj EMC /Suspect <>BDC -0.0034 Tc 4.058 0 Td (HS. )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 208.6966 241.2063 Tm (-)Tj -0.005 Tc 1.088 0 Td (Aerosol )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0006 Tc 8.9 0 0 8.9 250.9716 241.2063 Tm (inhala)Tj 0.38 0.38 0.372 rg 0 Tc 2.478 0 Td (\255)Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg 0.0041 Tc -25.555 -1.133 Td (tion )Tj EMC ET BT /T1_0 1 Tf -0.0148 Tc 8.9 0 0 8.9 66.1542 231.1226 Tm (and )Tj 0.027 Tc 2.158 0 Td (depth )Tj 0.05 Tc 10.0163 0 0 8.9 112.22 231.13 Tm (of )Tj 0.0059 Tc 8.9 0 0 8.9 126.64 231.13 Tm (deposition )Tj -0.0058 Tc 4.963 0 Td (in )Tj 0.0114 Tc 1.57 0 Td (the )Tj 0.0086 Tc 1.943 0 Td (human )Tj -0.0041 Tc 3.553 0 Td (lung. )Tj /T1_2 1 Tf 0.012 Tc 9 0 0 9 257.9 231.13 Tm (Arch )Tj 0.0036 Tc -23.634 -1.068 Td (Environ )Tj -0.0027 Tc 3.628 0 Td (Health, )Tj 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0053 Tc 8.9 0 0 8.9 108.65 221.52 Tm (1977, )Tj 0.247 0.251 0.243 rg 0.0137 Tc 2.612 0 Td (32, )Tj -0.035 Tc 8.8327 0 0 8.9 147.05 221.52 Tm (131)Tj 0.118 0.118 0.106 rg 0 Tc 8.9 0 0 8.9 159.74 221.52 Tm (-)Tj 0.247 0.251 0.243 rg -0.0202 Tc 0.624 0 Td (137. )Tj -0.023 Tc -13.429 -1.133 Td (15. )Tj -0.0007 Tc 2.079 0 Td (Laube )Tj 0.0298 Tc 2.913 0 Td (BL, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0186 Tc 8.9 0 0 8.9 107.8441 211.4363 Tm (Smith )Tj EMC ET BT /T1_0 1 Tf -0.0277 Tc 8.9 0 0 8.9 133.8855 211.4363 Tm (DL. )Tj 0.0161 Tc 1.997 0 Td (Wagner )Tj -0.0324 Tc 3.666 0 Td (HN, )Tj 0.0152 Tc 2.058 0 Td (Normal )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0278 Tc 8.9 0 0 8.9 233.7257 211.4363 Tm (PS, )Tj EMC ET BT /T1_0 1 Tf -0.0052 Tc 8.9 0 0 8.9 250.5467 211.4363 Tm (Adams )Tj 0.0143 Tc -23.085 -1.131 Td (KG)Tj 0.118 0.118 0.106 rg 0 Tc 1.494 0 Td (. )Tj 0.247 0.251 0.243 rg 0.656 0 Td (-)Tj 0.0407 Tc 0.919 0 Td (The )Tj 0.318 0.318 0.31 rg 0.0242 Tc 2.048 0 Td (effect )Tj 0.247 0.251 0.243 rg 0.05 Tc 9.4598 0 0 8.9 115.59 201.37 Tm (of )Tj 0.015 Tc 8.9 0 0 8.9 126.73 201.37 Tm (bronchial )Tj 0.0055 Tc 4.304 0 Td (obstruction )Tj 0.0451 Tc 5.016 0 Td (on )Tj 0.0001 Tc 1.455 0 Td (central )Tj -0.0021 Tc 3.236 0 Td (airway )Tj 0.0059 Tc 5.34 60.728 Td (deposition )Tj 0.05 Tc 9.4598 0 0 8.9 339.75 741.85 Tm (of )Tj 0 Tc 8.9 0 0 8.9 350.79 741.85 Tm (a )Tj 0.0031 Tc 0.804 0 Td (saline )Tj -0.0026 Tc 2.755 0 Td (aerosol )Tj -0.0058 Tc 3.292 0 Td (in )Tj 0.0161 Tc 1.142 0 Td (patient )Tj 0.0027 Tc 3.18 0 Td (with )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0009 Tc 8.9 0 0 8.9 469.8275 741.85 Tm (astluna. )Tj EMC ET BT /T1_2 1 Tf 0.05 Tc 9.4102 0 0 8.8 500.3 741.85 Tm (Am )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0444 Tc 8.8 0 0 8.8 515.59 741.85 Tm (Rev )Tj EMC ET BT /T1_2 1 Tf 0.0017 Tc 9 0 0 9 299.11 732.24 Tm (Respir )Tj -0.0139 Tc 2.989 0 Td (Dis, )Tj /T1_0 1 Tf -0.0053 Tc 8.9 0 0 8.9 344.33 732.24 Tm (1986, )Tj -0.0022 Tc 2.643 0 Td (133, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.031 Tc 8.9 0 0 8.9 386.3113 732.24 Tm (740-743. )Tj EMC ET BT /T1_0 1 Tf 0.004 Tc 8.9 0 0 8.9 299.6876 722.1741 Tm (16. )Tj 0.0027 Tc 2.242 0 Td (Dolovich )Tj -0.0073 Tc 4.207 0 Td (MB, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0181 Tc 8.9 0 0 8.9 377.1265 722.1741 Tm (Sanchis )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.8613 0 0 8.9 409.87 722.17 Tm (J, )Tj 0.0189 Tc 8.9 0 0 8.9 419.96 722.17 Tm (Rossman )Tj 0.0225 Tc 4.255 0 Td (C, )Tj 0.0214 Tc 1.417 0 Td (Newhouse )Tj -0.0063 Tc 4.791 0 Td (MT. )Tj 0.118 0.118 0.106 rg 0 Tc -24.061 -1.08 Td (-)Tj 0.247 0.251 0.243 rg -0.002 Tc 0.926 0 Td (Aeros)Tj 0.38 0.38 0.372 rg 0 Tc 2.42 0 Td (o)Tj 0.247 0.251 0.243 rg 0.487 0 Td (l )Tj 0.318 0.318 0.31 rg -0.0009 Tc 0.656 0 Td (penctrance: )Tj 0 Tc 5.058 0 Td (a )Tj 0.0112 Tc 0.804 0 Td (sensitive )Tj 0.247 0.251 0.243 rg -0.0058 Tc 3.944 0 Td (in)Tj 0.38 0.38 0.372 rg 0.0111 Tc 0.808 0 Td (dex )Tj 0.05 Tc 10.0163 0 0 8.9 449.66 712.56 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.7562 0 0 8.9 460.34 712.56 Tm (pe)Tj 0.247 0.251 0.243 rg -0.0152 Tc 8.9 0 0 8.9 469.91 712.56 Tm (riph)Tj 0.38 0.38 0.372 rg 0.0113 Tc 1.609 0 Td (eral )Tj EMC ET BT /T1_0 1 Tf -0.0036 Tc 8.9 0 0 8.9 501.5139 712.56 Tm (airways )Tj 0.247 0.251 0.243 rg 0.0207 Tc -22.758 -1.133 Td (obstruct)Tj 0.38 0.38 0.372 rg -0.035 Tc 8.5969 0 0 8.9 328.73 702.48 Tm (io)Tj 0.247 0.251 0.243 rg 8.7678 0 0 8.9 335.03 702.48 Tm (n. )Tj 0.318 0.318 0.31 rg /T1_3 1 Tf 0 Tc 8.2 0 0 8.2 344.56 702.48 Tm (J )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0004 Tc 9 0 0 9 352.41 702.48 Tm (Iippi )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg -0.0083 Tc 2.291 0 Td (Phy)Tj 0.38 0.38 0.372 rg 0.0328 Tc 1.489 0 Td (sio)Tj 0.247 0.251 0.243 rg -0.035 Tc 8.8532 0 0 9 397.34 702.48 Tm (l, )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0053 Tc 8.9 0 0 8.9 406.25 702.48 Tm (1976, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0029 Tc 8.9 0 0 8.9 429.0785 702.48 Tm (40, )Tj EMC ET BT /T1_0 1 Tf 0.0451 Tc 8.9 0 0 8.9 443.4787 702.48 Tm (468-471. )Tj 0.247 0.251 0.243 rg -0.0117 Tc -16.156 -1.078 Td (17)Tj 0.118 0.118 0.106 rg 0 Tc 0.985 0 Td (. )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf 0.0207 Tc 8.9 0 0 8.9 318.5583 692.8858 Tm (Svart)Tj 0.38 0.38 0.372 rg -0.0005 Tc 2.111 0 Td (cngren )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.035 Tc 8.7796 0 0 8.9 366.2 692.89 Tm (M, )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf 0.0258 Tc 8.9 0 0 8.9 380.6 692.89 Tm (Phil)Tj 0.38 0.38 0.372 rg 0.0074 Tc 1.615 0 Td (ipso)Tj 0.247 0.251 0.243 rg 0 Tc 1.679 0 Td (n )Tj EMC ET BT /T1_0 1 Tf 8.9 0 0 8.9 419.0035 692.89 Tm (K)Tj 0.38 0.38 0.372 rg 0.69 0 Td (, )Tj 0.247 0.251 0.243 rg -0.0023 Tc 0.765 0 Td (Linnm)Tj 0.38 0.38 0.372 rg -0.0151 Tc 2.692 0 Td (an )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 468.9147 692.89 Tm (L)Tj 0.38 0.38 0.372 rg 0.583 0 Td (, )Tj EMC ET BT /T1_0 1 Tf 0.0066 Tc 8.9 0 0 8.9 479.9151 692.89 Tm (Carnner )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 513.0854 692.89 Tm (P)Tj 0.463 0.463 0.455 rg 0.578 0 Td (. )Tj EMC ET BT /T1_0 1 Tf 8.9 0 0 8.9 524.068 692.89 Tm (-)Tj 0.318 0.318 0.31 rg -0.005 Tc -25.231 -1.134 Td (Airway )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.006 Tc 8.9 0 0 8.9 329.2826 682.7974 Tm (resistance )Tj EMC ET BT /T1_0 1 Tf -0.0148 Tc 8.9 0 0 8.9 367.606 682.7974 Tm (and )Tj 0.0059 Tc 1.781 0 Td (deposition )Tj 0.38 0.38 0.372 rg 0 Tc 4.584 0 Td (o)Tj 0.247 0.251 0.243 rg 0.537 0 Td (f )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0032 Tc 8.9 0 0 8.9 434.9078 682.7974 Tm (parti)Tj 0.38 0.38 0.372 rg 0.0107 Tc 1.876 0 Td (cles )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0058 Tc 8.9 0 0 8.9 469.3864 682.7974 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0114 Tc 8.9 0 0 8.9 479.5146 682.7974 Tm (the )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf -0.035 Tc 8.861 0 0 8.9 494.33 682.8 Tm (lun)Tj 0.38 0.38 0.372 rg -0.0342 Tc 8.9 0 0 8.9 505.37 682.8 Tm (g. )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_2 1 Tf -0.035 Tc 8.9842 0 0 9.6 515.59 682.8 Tm (Exp )Tj EMC ET BT /T1_2 1 Tf -0.0097 Tc 9 0 0 9 299.13 673.21 Tm (Lung )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_2 1 Tf -0.035 Tc 8.9848 0 0 9 321.19 673.21 Tm (Re)Tj 0.38 0.38 0.372 rg 8.8126 0 0 9 330.27 673.21 Tm (s, )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0323 Tc 8.9 0 0 8.9 340.49 673.21 Tm (1984, )Tj 0.38 0.38 0.372 rg 0.0297 Tc 2.506 0 Td (7, )Tj 0.0302 Tc 1.137 0 Td (257-269. )Tj 0.318 0.318 0.31 rg -0.0117 Tc -8.281 -1.134 Td (18)Tj 0.463 0.463 0.455 rg 0 Tc 1.039 0 Td (. )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf -0.035 Tc 8.7587 0 0 8.9 318.56 663.12 Tm (Sv)Tj 0.38 0.38 0.372 rg -0.0117 Tc 8.9 0 0 8.9 328.23 663.12 Tm (artengren )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 365.7168 663.12 Tm (M)Tj 0.38 0.38 0.372 rg 0.96 0 Td (, )Tj 0.247 0.251 0.243 rg -0.035 Tc 8.5915 0 0 8.9 380.6 663.12 Tm (Ph)Tj 0.38 0.38 0.372 rg -0.0012 Tc 8.9 0 0 8.9 390.17 663.12 Tm (ilipson )Tj 0.318 0.318 0.31 rg -0.035 Tc 8.7287 0 0 8.9 418.52 663.12 Tm (K, )Tj 0.0031 Tc 8.9 0 0 8.9 431.47 663.12 Tm (Linnman )Tj 0.247 0.251 0.243 rg -0.035 Tc 8.8589 0 0 8.9 468.43 663.12 Tm (L, )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0299 Tc 8.9 0 0 8.9 479.91 663.12 Tm (Camncr )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg 0 Tc 3.727 0 Td (P)Tj 0.38 0.38 0.372 rg 0.578 0 Td (. )Tj EMC ET BT /T1_0 1 Tf 8.9 0 0 8.9 523.5823 663.12 Tm (-)Tj 0.247 0.251 0.243 rg -25.18 -1.131 Td (R)Tj 0.38 0.38 0.372 rg -0.0013 Tc 0.588 0 Td (egional )Tj 0.318 0.318 0.31 rg -0.0001 Tc 3.399 0 Td (deposition )Tj 0.05 Tc 9.4598 0 0 8.9 375.75 653.05 Tm (of )Tj 0.247 0.251 0.243 rg -0.0103 Tc 8.9 0 0 8.9 387.37 653.05 Tm (parti)Tj 0.38 0.38 0.372 rg 0 Tc 1.822 0 Td (c)Tj 0.247 0.251 0.243 rg 0.488 0 Td (l)Tj 0.38 0.38 0.372 rg -0.0033 Tc 0.267 0 Td (es )Tj 0.318 0.318 0.31 rg -0.035 Tc 8.5969 0 0 8.9 421.85 653.05 Tm (in )Tj 0.0086 Tc 8.9 0 0 8.9 431.99 653.05 Tm (human )Tj -0.012 Tc 3.229 0 Td (lung )Tj 0.0039 Tc 2.209 0 Td (after )Tj -0.0031 Tc 2.267 0 Td (induced )Tj 0.38 0.38 0.372 rg -0.0018 Tc -22.589 -1.133 Td (bronchoconstriction. )Tj 0.247 0.251 0.243 rg /T1_2 1 Tf 0 Tc 9 0 0 9 376.39 642.97 Tm (E)Tj 0.38 0.38 0.372 rg 0.05 Tc 9.1042 0 0 9 381.22 642.97 Tm (xp )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_2 1 Tf 0.0259 Tc 9 0 0 9 393.21 642.97 Tm (Lung )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg 0 Tc 2.504 0 Td (R)Tj 0.38 0.38 0.372 rg -0.0009 Tc 0.57 0 Td (es, )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0053 Tc 8.9 0 0 8.9 435.05 642.97 Tm (1986, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.023 Tc 8.9 0 0 8.9 459.0533 642.97 Tm (10, )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0302 Tc 8.9 0 0 8.9 473.231 642.97 Tm (223-233. )Tj 0.318 0.318 0.31 rg -0.023 Tc -19.499 -1.08 Td (19. )Tj 0.247 0.251 0.243 rg 0 Tc 2.081 0 Td (W)Tj 0.38 0.38 0.372 rg 0.91 0 Td (a)Tj 0.247 0.251 0.243 rg 0.494 0 Td (n)Tj 0.38 0.38 0.372 rg -0.0228 Tc 0.485 0 Td (ne)Tj 0.247 0.251 0.243 rg 0 Tc 0.917 0 Td (r )Tj 0.318 0.318 0.31 rg -0.035 Tc 8.763 0 0 8.9 350.38 633.36 Tm (A, )Tj 0.022 Tc 8.9 0 0 8.9 362.36 633.36 Tm (Brodman )Tj 0.247 0.251 0.243 rg -0.0294 Tc 4.313 0 Td (JM)Tj 0.38 0.38 0.372 rg 0 Tc 1.284 0 Td (, )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0021 Tc 8.9 0 0 8.9 418.9907 633.36 Tm (Perez )Tj EMC ET BT /T1_0 1 Tf -0.0181 Tc 9.4 0 0 9.4 442.51 633.36 Tm (J, )Tj 0.247 0.251 0.243 rg 0 Tc 8.9 0 0 8.9 453.08 633.36 Tm (H)Tj 0.38 0.38 0.372 rg 0.0071 Tc 0.696 0 Td (enke )Tj 0.247 0.251 0.243 rg -0.0002 Tc 2.324 0 Td (JE, )Tj -0.024 Tc 1.781 0 Td (Kim )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf -0.0139 Tc 8.9 0 0 8.9 515.4423 633.36 Tm (CS)Tj 0.525 0.525 0.514 rg 0 Tc 1.23 0 Td (. )Tj EMC ET BT 0.463 0.463 0.455 rg /T1_0 1 Tf 8.9 0 0 8.9 298.4692 623.2941 Tm (-)Tj 0.247 0.251 0.243 rg -0.0322 Tc 0.98 0 Td (Vari)Tj 0.38 0.38 0.372 rg -0.0228 Tc 1.772 0 Td (abili)Tj 0.247 0.251 0.243 rg 0 Tc 1.734 0 Td (t)Tj 0.38 0.38 0.372 rg 0.271 0 Td (y )Tj 0.05 Tc 9.4598 0 0 8.9 348.39 623.29 Tm (of )Tj -0.0021 Tc 8.9 0 0 8.9 359.43 623.29 Tm (airway )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0077 Tc 8.9 0 0 8.9 386.3881 623.29 Tm (responsiveness )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.4365 0 0 8.9 444.46 623.29 Tm (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0064 Tc 8.9 0 0 8.9 454.55 623.29 Tm (histanline )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg -0.0116 Tc 4.306 0 Td (aerosol )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.5969 0 0 8.9 522.17 623.29 Tm (in )Tj 0.318 0.318 0.31 rg 0.0068 Tc 8.9 0 0 8.9 299.03 613.21 Tm (nonnal )Tj 0.38 0.38 0.372 rg -0.009 Tc 3.169 0 Td (subjects: )Tj 0.318 0.318 0.31 rg 0.0218 Tc 3.843 0 Td (role )Tj 0.38 0.38 0.372 rg 0.05 Tc 9.4598 0 0 8.9 378.63 613.21 Tm (of )Tj 0.318 0.318 0.31 rg -0.0001 Tc 8.9 0 0 8.9 389.2 613.21 Tm (deposition)Tj 0.463 0.463 0.455 rg 0 Tc 4.249 0 Td (. )Tj 0.318 0.318 0.31 rg /T1_2 1 Tf 0.05 Tc 9.0617 0 0 8.8 432.14 613.21 Tm (Am )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0001 Tc 9 0 0 9 447.91 613.21 Tm (Rev )Tj EMC ET BT /T1_2 1 Tf 0.0123 Tc 9 0 0 9 464.713 613.21 Tm (Respir )Tj -0.0317 Tc 2.989 0 Td (Dis. )Tj /T1_0 1 Tf -0.0323 Tc 8.9 0 0 8.9 510.41 613.21 Tm (1985, )Tj 0.247 0.251 0.243 rg -0.0202 Tc -23.73 -1.134 Td (131, )Tj 0.05 Tc 9.0561 0 0 8.9 317.65 603.12 Tm (3-7. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0047 Tc 8.9 0 0 8.9 298.51 593.53 Tm (20. )Tj EMC ET BT /T1_0 1 Tf 0.018 Tc 8.9 0 0 8.9 317.1911 593.53 Tm (Gillett )Tj -0.0084 Tc 3.026 0 Td (MK, )Tj 0.0106 Tc 2.265 0 Td (Briggs )Tj 0.05 Tc 9.15 0 0 8.9 392.12 593.53 Tm (BA)Tj 0.118 0.118 0.106 rg 0 Tc 8.9 0 0 8.9 404.98 593.53 Tm (, )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf 0.0145 Tc 8.9 0 0 8.9 410.7205 593.53 Tm (Snashall )Tj EMC /Suspect <>BDC 0.0257 Tc 3.897 0 Td (PD. )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 463.1059 593.53 Tm (-)Tj 0.0081 Tc 0.972 0 Td (Central )Tj 0.0055 Tc 3.399 0 Td (deposi\255)Tj 0.0041 Tc -22.807 -1.08 Td (tion )Tj 0.318 0.318 0.31 rg 0.05 Tc 10.0163 0 0 8.9 319.58 583.92 Tm (of )Tj 0.247 0.251 0.243 rg 0.0193 Tc 8.9 0 0 8.9 334.47 583.92 Tm (aerosols )Tj 0.042 Tc 4.207 0 Td (as )Tj 0 Tc 1.672 0 Td (a )Tj 0.0252 Tc 1.188 0 Td (determining )Tj 0.0158 Tc 5.93 0 Td (factor )Tj -0.0058 Tc 3.239 0 Td (in )Tj 0.0217 Tc 1.573 0 Td (bronchial )Tj 0.0085 Tc -21.899 -1.131 Td (responsiveness. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0164 Tc 9 0 0 9 357.42 573.85 Tm (Clin )Tj EMC ET BT /T1_2 1 Tf 0.0043 Tc 9 0 0 9 376.311 573.85 Tm (Sci. )Tj /T1_0 1 Tf -0.0053 Tc 8.9 0 0 8.9 394.25 573.85 Tm (1986, )Tj -0.035 Tc 8.6773 0 0 8.9 417.51 573.85 Tm (71 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0025 Tc 8.9 0 0 8.9 429.98 573.85 Tm (\(Suppl. )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0185 Tc 8.9 0 0 8.9 460.4892 573.85 Tm (15\), )Tj 0.247 0.251 0.243 rg -0.0142 Tc 1.905 0 Td (82. )Tj /T1_2 1 Tf -0.013 Tc 9 0 0 9 298.65 544.56 Tm (Influ)Tj 0.38 0.38 0.372 rg 0 Tc 1.901 0 Td (e)Tj 0.247 0.251 0.243 rg 0.377 0 Td (n)Tj 0.463 0.463 0.455 rg 0.478 0 Td (c)Tj 0.318 0.318 0.31 rg 0.479 0 Td (e )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 8.8032 0 0 9 336.43 544.56 Tm (du )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_2 1 Tf 0.0019 Tc 9 0 0 9 349.85 544.56 Tm (calibre )Tj 0.318 0.318 0.31 rg 0.0191 Tc 3.309 0 Td (des )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_2 1 Tf 0.0087 Tc 9 0 0 9 396.434 544.56 Tm (voies )Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg 0.0156 Tc 2.506 0 Td (aeriennes )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg 0.0034 Tc 4.49 0 Td (sur )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg -0.035 Tc 8.1011 0 0 9 475.76 544.56 Tm (Ia )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_2 1 Tf 0.0061 Tc 9 0 0 9 486.67 544.56 Tm (dose )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0015 Tc 9 0 0 9 507.73 544.56 Tm (intra)Tj 0.525 0.525 0.514 rg 0 Tc 1.978 0 Td (\255)Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg 0.0008 Tc -25.239 -0.96 Td (pulmonaire )Tj EMC ET BT /T1_2 1 Tf 0.0401 Tc 9 0 0 9 344.56 535.92 Tm (et )Tj -0.035 Tc 7.5224 0 0 9 357.2 535.92 Tm (Ia )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0125 Tc 9 0 0 9 368.59 535.92 Tm (distribwion )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg 0.0191 Tc 5.28 0 Td (des )Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg -0.035 Tc 8.9445 0 0 9 433.38 535.92 Tm (aerosoL,\267 )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg 7.8688 0 0 9 469.82 535.92 Tm (inJra)Tj 0.247 0.251 0.243 rg 0 Tc 9 0 0 9 485.66 535.92 Tm (l)Tj 0.38 0.38 0.372 rg 0.0348 Tc 0.269 0 Td (es )Tj EMC /Suspect <>BDC 0.463 0.463 0.455 rg -0.0133 Tc 1.388 0 Td (cite )Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg 0.0075 Tc 1.97 0 Td (les )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_2 1 Tf 0.0164 Tc 9 0 0 9 298.109 526.803 Tm (suje)Tj 0.247 0.251 0.243 rg 0 Tc 1.638 0 Td (t)Tj 0.38 0.38 0.372 rg 0.282 0 Td (s )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_2 1 Tf 9 0 0 9 322.877 526.803 Tm (1)Tj 0.38 0.38 0.372 rg -0.035 Tc 7.2886 0 0 9 325.31 526.8 Tm (10)Tj 0.247 0.251 0.243 rg 0.05 Tc 9.0925 0 0 9 331.63 526.8 Tm (rmata )Tj EMC ET BT /T1_2 1 Tf -0.0132 Tc 9 0 0 9 358.48 526.8 Tm (et )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_2 1 Tf -0.0018 Tc 9 0 0 9 369.064 526.8 Tm (aslhmatiques. )Tj EMC ET BT /T1_3 1 Tf -0.035 Tc 8.3724 0 0 9.8 423.25 526.8 Tm (K. )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_2 1 Tf 0.0166 Tc 9 0 0 9 435.18 526.8 Tm (Ch)Tj 0.247 0.251 0.243 rg -0.0183 Tc 1.236 0 Td (lln)Tj 0.38 0.38 0.372 rg 0.0356 Tc 0.927 0 Td (g, )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_2 1 Tf 0 Tc 9 0 0 9 466.167 526.8 Tm (K)Tj 0.38 0.38 0.372 rg 0.728 0 Td (. )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_2 1 Tf 9 0 0 9 477.705 526.8 Tm (J)Tj 0.38 0.38 0.372 rg 0.0104 Tc 0.513 0 Td (eyasi)Tj 0.247 0.251 0.243 rg 0 Tc 2.083 0 Td (n)Tj 0.38 0.38 0.372 rg 0.441 0 Td (g)Tj 0.247 0.251 0.243 rg 0.0134 Tc 0.519 0 Td (h, )Tj EMC /Suspect <>BDC 0 Tc 1.24 0 Td (P)Tj 0.463 0.463 0.455 rg 0.569 0 Td (. )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg -25.324 -1.013 Td (S)Tj 0.247 0.251 0.243 rg 0.529 0 Td (n)Tj 0.38 0.38 0.372 rg -0.0156 Tc 0.479 0 Td (aslrall)Tj 0.525 0.525 0.514 rg 0 Tc (. )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf 8.9 0 0 8.9 299 508.09 Tm (R)Tj 0.38 0.38 0.372 rg -0.0183 Tc 0.646 0 Td (ESUME: )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0026 Tc 8.9 0 0 8.9 341.3195 508.09 Tm (Nous )Tj 0.38 0.38 0.372 rg -0.0005 Tc 2.52 0 Td (avons )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf 0.007 Tc 8.9 0 0 8.9 388.7298 508.09 Tm (investigue )Tj EMC /Suspect <>BDC -0.0062 Tc 4.639 0 Td (Ia )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf 0.013 Tc 8.9 0 0 8.9 440.1451 508.09 Tm (rel)Tj 0.38 0.38 0.372 rg 0 Tc 1.07 0 Td (a)Tj 0.247 0.251 0.243 rg 0.493 0 Td (t)Tj 0.38 0.38 0.372 rg 0.0168 Tc 0.21 0 Td (ion )Tj 0.0183 Tc 1.778 0 Td (entre )Tj 0.05 Tc 8.9036 0 0 8.9 493.37 508.09 Tm (lc )Tj 0.0181 Tc 8.9 0 0 8.9 503.43 508.09 Tm (calibre )Tj 0.318 0.318 0.31 rg -0.0143 Tc -23.028 -1.079 Td (des )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.8135 0 0 8.9 314.86 498.49 Tm (voi.cs )Tj EMC /Suspect <>BDC 0.0019 Tc 8.9 0 0 8.9 338.79 498.49 Tm (aerienncs )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.05 Tc 8.9607 0 0 8.9 377.19 498.49 Tm (ct )Tj 0.318 0.318 0.31 rg -0.0062 Tc 8.9 0 0 8.9 388.74 498.49 Tm (Ia )Tj 0.0215 Tc 1.292 0 Td (dose )Tj 0.38 0.38 0.372 rg 0.0009 Tc 2.426 0 Td (et )Tj 0.318 0.318 0.31 rg -0.035 Tc 8.6002 0 0 8.9 433.37 498.49 Tm (la )Tj 0.0086 Tc 8.9 0 0 8.9 444.4 498.49 Tm (distribution )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0171 Tc 8.9 0 0 8.9 490.9559 498.49 Tm (d'aerosols )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf -0.0014 Tc 8.9 0 0 8.9 298.4845 488.4063 Tm (inhales )Tj 0.318 0.318 0.31 rg 0.0083 Tc 3.234 0 Td (chez )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf 0.0422 Tc 8.9 0 0 8.9 347.2031 488.4063 Tm (10 )Tj EMC ET BT /T1_0 1 Tf 0.0031 Tc 8.9 0 0 8.9 359.8589 488.4063 Tm (sujets )Tj 0.0106 Tc 2.656 0 Td (normaux )Tj 0.05 Tc 8.9571 0 0 8.9 419.43 488.41 Tm (et )Tj 0 Tc 8.9 0 0 8.9 429.49 488.41 Tm (6 )Tj 0.0039 Tc 0.973 0 Td (asthmatiques. )Tj -0.035 Tc 8.8252 0 0 10 491.47 488.41 Tm (Les )Tj 0.0031 Tc 8.9 0 0 8.9 507.71 488.41 Tm (sujets )Tj 0.0459 Tc -23.563 -1.133 Td (ont )Tj 0.0114 Tc 1.673 0 Td (inhale )Tj 0.0339 Tc 2.812 0 Td (une )Tj 0.0059 Tc 1.819 0 Td (solution )Tj 0.0139 Tc 3.613 0 Td (saline )Tj 0.0274 Tc 2.756 0 Td (d'aerosol )Tj 0.016 Tc 4.152 0 Td (contenant )Tj 0.0337 Tc 4.316 0 Td (du )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 5.7 0 0 5.7 498.18 478.33 Tm (9)Tj 0.589 0.505 Td (9)Tj 0.05 Tc 8.9652 0 0 8.9 504.31 478.33 Tm ("'Tc0)Tj 0 Tc 5.7 0 0 5.7 524.62 474.97 Tm (4 )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0033 Tc 8.9 0 0 8.9 298.57 468.72 Tm (produit )Tj 0.0137 Tc 3.182 0 Td (par )Tj 0.247 0.251 0.243 rg -0.035 Tc 8.4613 0 0 8.9 342.24 468.72 Tm (un )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 354.23 468.72 Tm (n)Tj 0.38 0.38 0.372 rg 0.05 Tc 9.3707 0 0 8.9 357.98 468.72 Tm (eb)Tj 0.247 0.251 0.243 rg -0.0318 Tc 8.9 0 0 8.9 367.2 468.72 Tm (u1iseur )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg /C0_0 1 Tf 0 Tc 4.32 0 0 6.72 394.57 468.72 Tm <0063006F>Tj 0.247 0.251 0.243 rg 5.0401 0 0 6.72 402.73 468.72 Tm <006E006E>Tj 0.38 0.38 0.372 rg 3.84 0 0 6.72 412.33 468.72 Tm <00650063>Tj 0.247 0.251 0.243 rg 4.32 0 0 6.72 420.49 468.72 Tm <0075>Tj 0.38 0.38 0.372 rg 2.88 0 0 6.72 423.85 468.72 Tm <007E0020>Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg 3.84 0 0 6.72 430.08 468.72 Tm <007E0020>Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf -0.0286 Tc 8.9 0 0 8.9 437.28 468.72 Tm (un )Tj 0.318 0.318 0.31 rg 0.003 Tc 1.393 0 Td (dosimctre, )Tj -0.0129 Tc 4.645 0 Td (tandis )Tj 0.247 0.251 0.243 rg 0.0349 Tc 2.69 0 Td (qu)Tj 0.38 0.38 0.372 rg 0 Tc 1.024 0 Td (e )Tj 0.318 0.318 0.31 rg -0.0076 Tc -25.4 -1.131 Td (les )Tj 0.38 0.38 0.372 rg 0.0048 Tc 1.831 0 Td (cham)Tj 0.247 0.251 0.243 rg 0 Tc 2.222 0 Td (p)Tj 0.38 0.38 0.372 rg 0.524 0 Td (s )Tj 0.247 0.251 0.243 rg -0.0202 Tc 1.094 0 Td (pu)Tj 0.38 0.38 0.372 rg 0 Tc 1.016 0 Td (l)Tj 0.247 0.251 0.243 rg 0.275 0 Td (m)Tj 0.38 0.38 0.372 rg 0.008 Tc 0.748 0 Td (onaires )Tj -0.0008 Tc 3.716 0 Td (so)Tj 0.247 0.251 0.243 rg 0.0353 Tc 0.876 0 Td (nt )Tj 0.38 0.38 0.372 rg 0.0098 Tc 1.551 0 Td (scintig)Tj 0.247 0.251 0.243 rg 0 Tc 2.71 0 Td (r)Tj 0.38 0.38 0.372 rg -0.0151 Tc 0.369 0 Td (ap)Tj 0.247 0.251 0.243 rg -0.018 Tc 0.926 0 Td (hi)Tj 0.38 0.38 0.372 rg 0.05 Tc 8.907 0 0 8.9 464.07 458.65 Tm (es )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /C0_0 1 Tf 0 Tc 3.84 0 0 6.72 478.08 458.65 Tm <007E0020>Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf -0.035 Tc 8.5916 0 0 8.9 489.06 458.65 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0102 Tc 8.9 0 0 8.9 501.53 458.65 Tm (gamma )Tj -0.0088 Tc -22.87 -1.079 Td (can)Tj 0.247 0.251 0.243 rg 0 Tc 1.324 0 Td (1)Tj 0.38 0.38 0.372 rg 0.348 0 Td (e)Tj 0.247 0.251 0.243 rg -0.0275 Tc 0.494 0 Td (ra. )Tj 0.318 0.318 0.31 rg -0.016 Tc 1.667 0 Td (La )Tj 0.38 0.38 0.372 rg 0.0215 Tc 1.615 0 Td (dose )Tj 0.318 0.318 0.31 rg -0.0202 Tc 2.481 0 Td (du )Tj 0.0044 Tc 1.628 0 Td (poumon )Tj 0.0159 Tc 3.927 0 Td (droit )Tj 0 Tc 2.588 0 Td (a )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0218 Tc 8.9 0 0 8.9 450.6309 449.0469 Tm (cte )Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg 0.0136 Tc 1.78 0 Td (calculee )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0116 Tc 8.9 0 0 8.9 501.5122 449.0469 Tm (commc )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0089 Tc 8.9 0 0 8.9 298.0938 438.9632 Tm (pourccntage )Tj EMC ET BT /T1_0 1 Tf 0.0368 Tc 8.9 0 0 8.9 346.0025 438.9632 Tm (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.5916 0 0 8.9 359.46 438.97 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0215 Tc 8.9 0 0 8.9 369.52 438.97 Tm (dose )Tj 0.247 0.251 0.243 rg 0 Tc 2.434 0 Td (t)Tj 0.38 0.38 0.372 rg 0.019 Tc 0.263 0 Td (otale)Tj 0.247 0.251 0.243 rg 0 Tc 1.984 0 Td [(. )-270(L)]TJ 0.38 0.38 0.372 rg 1.412 0 Td (a )Tj 0.247 0.251 0.243 rg 0.041 Tc 0.864 0 Td (di)Tj 0.38 0.38 0.372 rg 0.0192 Tc 0.803 0 Td (stribut)Tj 0.247 0.251 0.243 rg 0 Tc 2.703 0 Td (i)Tj 0.38 0.38 0.372 rg 0.215 0 Td (o)Tj 0.247 0.251 0.243 rg 0.547 0 Td (n )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0204 Tc 8.9 0 0 8.9 478.4827 438.97 Tm (int)Tj 0.38 0.38 0.372 rg 0.0031 Tc 1.031 0 Td (ra-p)Tj 0.247 0.251 0.243 rg -0.0216 Tc 1.619 0 Td (ulm)Tj 0.38 0.38 0.372 rg -0.0088 Tc 1.555 0 Td (on)Tj 0.525 0.525 0.514 rg 0 Tc 1.022 0 Td (\255)Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0084 Tc 8.9 0 0 8.9 297.9729 428.8863 Tm (aire )Tj 0 Tc 1.888 0 Td (a )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0486 Tc 8.9 0 0 8.9 321.9762 428.8863 Tm (etc )Tj EMC /Suspect <>BDC -0.0156 Tc 1.626 0 Td (mesuroo )Tj EMC ET BT /T1_0 1 Tf 0.009 Tc 8.9 0 0 8.9 369.4577 428.8863 Tm (sous )Tj -0.008 Tc 2.269 0 Td (forme )Tj 0.05 Tc 9.2257 0 0 8.9 413.67 428.89 Tm (d'un )Tj 0.318 0.318 0.31 rg 0.0018 Tc 8.9 0 0 8.9 434.33 428.89 Tm (index )Tj 0.0368 Tc 2.642 0 Td (de )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.01 Tc 8.9 0 0 8.9 469.93 428.89 Tm (penetration )Tj EMC /Suspect <>BDC -0.0072 Tc 4.949 0 Td (\(P)Tj 0.247 0.251 0.243 rg 0 Tc 0.812 0 Td (l)Tj 0.38 0.38 0.372 rg 0.434 0 Td (\) )Tj EMC ET BT /T1_0 1 Tf 0.0104 Tc 8.9 0 0 8.9 297.9731 418.8063 Tm (\(=comptage )Tj 0.0127 Tc 5.18 0 Td (des )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 7.1768 0 0 9.7 359.39 418.81 Tm (1.o)Tj 0.247 0.251 0.243 rg 0 Tc 9.7 0 0 9.7 368.11 418.81 Tm (n)Tj 0.38 0.38 0.372 rg -0.035 Tc 9.189 0 0 9.7 372.41 418.81 Tm (cs )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.0014 Tc 8.9 0 0 8.9 383.53 418.81 Tm (perip)Tj 0.247 0.251 0.243 rg 0 Tc 2.101 0 Td (h)Tj 0.38 0.38 0.372 rg 0.0046 Tc 0.476 0 Td (eriques/com)Tj 0.247 0.251 0.243 rg 0.0147 Tc 4.973 0 Td (pta)Tj 0.38 0.38 0.372 rg 0.05 Tc 9.3224 0 0 8.9 461.68 418.81 Tm (gc )Tj EMC ET BT /T1_0 1 Tf 0.0127 Tc 8.9 0 0 8.9 473.68 418.81 Tm (des )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0137 Tc 8.9 0 0 8.9 488.5875 418.81 Tm (zones )Tj EMC ET BT /T1_0 1 Tf 0.0182 Tc 8.9 0 0 8.9 512.5463 418.81 Tm (cen)Tj 0.525 0.525 0.514 rg 0 Tc 1.455 0 Td (\255)Tj 0.318 0.318 0.31 rg 0.0011 Tc -25.555 -1.079 Td (trales\). )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf -0.016 Tc 8.9 0 0 8.9 328.7435 409.2069 Tm (Lc)Tj 0.38 0.38 0.372 rg 0 Tc 1.016 0 Td (s )Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg 0.0023 Tc 1.083 0 Td (astlunatiqucs )Tj EMC /Suspect <>BDC 0.0067 Tc 5.933 0 Td (avaient )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf -0.0286 Tc 8.9 0 0 8.9 432.4819 409.2069 Tm (un )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf 0 Tc 8.9 0 0 8.9 447.2915 409.2069 Tm (i)Tj 0.694 0.694 0.682 rg 0.149 0 Td (.)Tj 0.247 0.251 0.243 rg 0.127 0 Td (n)Tj 0.38 0.38 0.372 rg -0.0159 Tc 0.478 0 Td (dex )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.05 Tc 9.2683 0 0 8.9 472.71 409.21 Tm (de )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf -0.0159 Tc 8.9 0 0 8.9 487.69 409.21 Tm (pent!tration )Tj EMC ET BT /T1_0 1 Tf 0.0148 Tc 8.9 0 0 8.9 297.4703 399.1174 Tm (signific)Tj 0.247 0.251 0.243 rg -0.0099 Tc 3.079 0 Td (ativ)Tj 0.38 0.38 0.372 rg 0.0286 Tc 1.51 0 Td (emcnl )Tj 0 Tc 2.978 0 Td (p)Tj 0.247 0.251 0.243 rg -0.0091 Tc 0.53 0 Td (lus )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf -0.014 Tc 8.9 0 0 8.9 384.0139 399.1174 Tm (bas )Tj EMC ET BT /T1_0 1 Tf 0.0387 Tc 8.9 0 0 8.9 399.7669 399.1174 Tm (que )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0194 Tc 8.9 0 0 8.9 417.0596 399.1174 Tm (les )Tj EMC ET BT /T1_0 1 Tf 0.0139 Tc 8.9 0 0 8.9 431.3975 399.1174 Tm (sujcts )Tj 0.318 0.318 0.31 rg 0.0042 Tc 2.872 0 Td (normaux, )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.05 Tc 8.9571 0 0 8.9 495.27 399.12 Tm (et )Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg /T1_1 1 Tf -0.035 Tc 6.1473 0 0 8.7 506.28 399.12 Tm (i1 )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_2 1 Tf 0 Tc 9.2 0 0 9.2 515.27 399.12 Tm (y )Tj 0.318 0.318 0.31 rg /T1_0 1 Tf 8.9 0 0 8.9 524.07 399.12 Tm (a )Tj 0.247 0.251 0.243 rg -0.0286 Tc -25.392 -1.078 Td (un)Tj 0.38 0.38 0.372 rg 0 Tc 0.961 0 Td (e )Tj 0.318 0.318 0.31 rg 0.0035 Tc 0.98 0 Td (relation )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf -0.007 Tc 8.9 0 0 8.9 347.4584 389.5258 Tm (lin)Tj 0.38 0.38 0.372 rg 0.05 Tc 8.9059 0 0 8.9 357.03 389.53 Tm (ea)Tj 0.247 0.251 0.243 rg -0.0061 Tc 8.9 0 0 8.9 365.21 389.53 Tm (ire )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0183 Tc 8.9 0 0 8.9 378.6312 389.53 Tm (entre )Tj 0.247 0.251 0.243 rg 0.0287 Tc 2.591 0 Td (l'ind)Tj 0.38 0.38 0.372 rg -0.0064 Tc 1.885 0 Td (ex )Tj 0.0368 Tc 1.457 0 Td (de )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0154 Tc 8.9 0 0 8.9 444.0017 389.53 Tm (penetration )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.9571 0 0 8.9 489.99 389.53 Tm (et )Tj 0.247 0.251 0.243 rg -0.0036 Tc 8.9 0 0 8.9 501.05 389.53 Tm (la )Tj 0.38 0.38 0.372 rg 0.0478 Tc 1.184 0 Td (co)Tj 0.247 0.251 0.243 rg 0 Tc 0.98 0 Td (n)Tj 0.525 0.525 0.514 rg 0.529 0 Td (\255)Tj 0.318 0.318 0.31 rg 0.0105 Tc -25.562 -1.134 Td (ductance )Tj 0.0081 Tc 4.417 0 Td (specifique )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.05 Tc 9.7561 0 0 8.5 380.07 379.44 Tm (de )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg /C0_0 1 Tf 0 Tc 4.32 0 0 6.72 396 379.44 Tm <0062>Tj 0.38 0.38 0.372 rg 2.88 0 0 6.72 400.8 379.44 Tm <0061002E007E00650020>Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0127 Tc 8.9 0 0 8.9 418.48 379.44 Tm (des )Tj 0.0135 Tc 2.164 0 Td (voies )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf -0.0052 Tc 8.9 0 0 8.9 464.0658 379.44 Tm (a\243rienncs)Tj 0.247 0.251 0.243 rg 0 Tc 3.824 0 Td (, )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0048 Tc 8.9 0 0 8.9 507.2308 379.44 Tm (sGaw )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.3846 0 0 8.5 297.98 369.84 Tm (\(p>BDC /T1_0 1 Tf 8.9 0 0 8.9 346.056 369.84 Tm (V)Tj 0.38 0.38 0.372 rg -0.035 Tc 8.7621 0 0 8.9 352.27 369.84 Tm (EMS )Tj EMC /Suspect <>BDC -0.0121 Tc 8.9 0 0 8.9 373.82 369.84 Tm (\(p<0.05\). )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf -0.035 Tc 5.9087 0 0 8.9 409.24 369.84 Tm (11 )Tj 0.318 0.318 0.31 rg 0 Tc 8.9 0 0 8.9 418.07 369.84 Tm (n )Tj /T1_1 1 Tf 0.0384 Tc 0.636 0 Td ('y )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0222 Tc 8.9 0 0 8.9 433.8319 369.84 Tm (avah )Tj EMC /Suspect <>BDC 0.0127 Tc 2.276 0 Td (pas )Tj EMC ET BT /T1_0 1 Tf 0.0368 Tc 8.9 0 0 8.9 468.8801 369.84 Tm (de )Tj -0.0119 Tc 1.356 0 Td (relation )Tj 0.0183 Tc 3.335 0 Td (entre )Tj -0.0036 Tc -23.89 -1.133 Td (le )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0189 Tc 8.9 0 0 8.9 308.5466 359.7563 Tm (calib)Tj 0.247 0.251 0.243 rg 0 Tc 2.005 0 Td (r)Tj 0.38 0.38 0.372 rg 0.315 0 Td (e )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0127 Tc 8.9 0 0 8.9 337.8454 359.7563 Tm (des )Tj 0 Tc 1.894 0 Td (voies )Tj 0.0087 Tc 2.635 0 Td (acriennes )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.05 Tc 8.9571 0 0 8.9 417.03 359.76 Tm (et )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0036 Tc 8.9 0 0 8.9 428.09 359.76 Tm (la )Tj 0.38 0.38 0.372 rg 0.0215 Tc 1.239 0 Td (dose )Tj 0.247 0.251 0.243 rg 0.0337 Tc 2.427 0 Td (du )Tj 0.38 0.38 0.372 rg -0.0044 Tc 1.574 0 Td (poumo)Tj 0.247 0.251 0.243 rg 0 Tc 2.802 0 Td (n )Tj 0.318 0.318 0.31 rg 0.0059 Tc 0.963 0 Td (droit. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.002 Tc 8.9 0 0 8.9 298.0521 349.6941 Tm (Apres )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0132 Tc 8.9 0 0 8.9 326.3986 349.6941 Tm (bronc)Tj 0.247 0.251 0.243 rg 0 Tc 2.371 0 Td (h)Tj 0.38 0.38 0.372 rg -0.0081 Tc 0.478 0 Td (odi)Tj 0.247 0.251 0.243 rg 0 Tc 1.349 0 Td (l)Tj 0.38 0.38 0.372 rg 0.0074 Tc 0.267 0 Td (atation )Tj -0.0151 Tc 3.56 0 Td (au )Tj 0.05 Tc 9.5244 0 0 8.9 413.15 349.69 Tm (sa)Tj 0.247 0.251 0.243 rg -0.0016 Tc 8.9 0 0 8.9 421.37 349.69 Tm (lbutam)Tj 0.38 0.38 0.372 rg 0 Tc 2.857 0 Td (o)Tj 0.247 0.251 0.243 rg 0.54 0 Td (l )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0245 Tc 8.9 0 0 8.9 460.6902 349.69 Tm (\(sGa)Tj 0.247 0.251 0.243 rg 0 Tc 2.006 0 Td (w)Tj 0.38 0.38 0.372 rg 0.05 Tc 9.7417 0 0 8.9 484.75 349.69 Tm (+l0)Tj 0.247 0.251 0.243 rg 0 Tc 8.9 0 0 8.9 499.85 349.69 Tm (1)Tj 0.463 0.463 0.455 rg -0.017 Tc 0.357 0 Td (\2613)Tj 0.318 0.318 0.31 rg 0 Tc 1.153 0 Td (1 )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg 8.5 0 0 8.5 517.36 349.69 Tm (%)Tj 0.247 0.251 0.243 rg 0.898 0 Td (, )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg 0.016 Tc 8.9 0 0 8.9 298.06 340.09 Tm (moyennt\261 )Tj EMC ET BT /T1_0 1 Tf 0.0016 Tc 8.9 0 0 8.9 338.3058 340.09 Tm (errcur )Tj -0.0023 Tc 2.692 0 Td (standard )Tj 0.318 0.318 0.31 rg 0.0368 Tc 3.781 0 Td (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8.9 407.95 340.09 Tm (Ia )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf -0.0044 Tc 8.9 0 0 8.9 417.58 340.09 Tm (moyenne\), )Tj 0.247 0.251 0.243 rg 0.05 Tc 10.7372 0 0 8.9 458.31 340.09 Tm (l')Tj 0.38 0.38 0.372 rg -0.0116 Tc 8.9 0 0 8.9 464.57 340.09 Tm (index )Tj 0.318 0.318 0.31 rg 0.0368 Tc 2.534 0 Td (de )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 8.9 0 0 8.9 498.7282 340.09 Tm (pe)Tj 0.247 0.251 0.243 rg 0 Tc 0.969 0 Td (n)Tj 0.38 0.38 0.372 rg -0.0074 Tc 0.476 0 Td (etra\255)Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0138 Tc 8.9 0 0 8.9 298.0599 329.9974 Tm (tion )Tj 0.38 0.38 0.372 rg 0.0141 Tc 2.053 0 Td (passe )Tj 0.318 0.318 0.31 rg 0.0368 Tc 2.74 0 Td (de )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf -0.0107 Tc 8.9 0 0 8.9 353.6671 329.9974 Tm (0.73\2610.1)Tj 0.247 0.251 0.243 rg 0 Tc 3.751 0 Td (1 )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg 13.4 0 0 13.4 395.38 330 Tm (a )Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg 0.0153 Tc 8.9 0 0 8.9 404.33 330 Tm (1.09\2610.15 )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg 0.0115 Tc 4.662 0 Td (\(p<0.05\); )Tj EMC /Suspect <>BDC -0.0119 Tc 4.424 0 Td (apres )Tj EMC ET BT /T1_0 1 Tf 0.0002 Tc 8.9 0 0 8.9 508.816 330 Tm (bron\255)Tj 0.0045 Tc -23.742 -1.078 Td (choconstriction )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0 Tc 11.1 0 0 11.1 357.48 320.41 Tm (a )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf -0.035 Tc 8.5916 0 0 8.9 365.7 320.41 Tm (Ia )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0029 Tc 8.9 0 0 8.9 376.3 320.41 Tm (metaoholine )Tj 0.38 0.38 0.372 rg 0.005 Tc 5.438 0 Td (\(sGaw=62.6\2612.9%\), )Tj 0.247 0.251 0.243 rg 0 Tc 8.74 0 Td (l)Tj 0.38 0.38 0.372 rg 0.0103 Tc 0.374 0 Td ('index )Tj 0.318 0.318 0.31 rg 0.0368 Tc -23.405 -1.079 Td (de )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0204 Tc 8.9 0 0 8.9 310.5557 310.8069 Tm (penetr)Tj 0.247 0.251 0.243 rg 0 Tc 2.578 0 Td (a)Tj 0.38 0.38 0.372 rg -0.0138 Tc 0.439 0 Td (tion )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0113 Tc 8.9 0 0 8.9 355.5897 310.8069 Tm (dintinue )Tj 0.0368 Tc 3.829 0 Td (de )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf -0.023 Tc 8.9 0 0 8.9 403.356 310.8069 Tm (1.4)Tj 0.38 0.38 0.372 rg 0.0159 Tc 1.216 0 Td (2\2610.24 )Tj EMC /Suspect <>BDC /T1_1 1 Tf 0 Tc 12.4 0 0 12.4 444.83 310.81 Tm (a )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.0264 Tc 8.9 0 0 8.9 453.29 310.81 Tm (1.06\2610)Tj 0.525 0.525 0.514 rg 0 Tc 2.873 0 Td (.)Tj 0.38 0.38 0.372 rg 0.0436 Tc 0.23 0 Td (22 )Tj EMC /Suspect <>BDC -0.0053 Tc 1.558 0 Td (\(p<0.05\). )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0138 Tc 8.9 0 0 8.9 298.0206 300.7174 Tm (Les )Tj 0.247 0.251 0.243 rg 0 Tc 1.891 0 Td (m)Tj 0.38 0.38 0.372 rg 0.0046 Tc 0.748 0 Td (odifications )Tj 0.0368 Tc 5.231 0 Td (de )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_0 1 Tf 0.041 Tc 8.9 0 0 8.9 381.0398 300.7174 Tm (I' )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0116 Tc 8.9 0 0 8.9 386.7892 300.7174 Tm (index )Tj 0.0368 Tc 2.642 0 Td (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.01 Tc 8.9 0 0 8.9 423.3504 300.7174 Tm (penetration )Tj EMC ET BT /T1_0 1 Tf 0.0104 Tc 8.9 0 0 8.9 468.331 300.7174 Tm (sont )Tj 0.38 0.38 0.372 rg 0.0475 Tc 2.108 0 Td (en )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0044 Tc 8.9 0 0 8.9 500.0506 300.7174 Tm (corre)Tj 0.247 0.251 0.243 rg -0.035 Tc 8.6002 0 0 8.9 518.81 300.72 Tm (la)Tj 0.463 0.463 0.455 rg 0 Tc 8.9 0 0 8.9 524.54 300.72 Tm (\255)Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg 0.0041 Tc -25.501 -1.131 Td (tion )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg -0.0127 Tc 2.042 0 Td (avec )Tj EMC ET BT /T1_0 1 Tf -0.0076 Tc 8.9 0 0 8.9 335.9312 290.6541 Tm (les )Tj 0.318 0.318 0.31 rg 0.0055 Tc 1.516 0 Td (modifications )Tj 0.0368 Tc 5.98 0 Td (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.5916 0 0 8.9 415.62 290.65 Tm (Ia )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0152 Tc 8.9 0 0 8.9 425.67 290.65 Tm (conductance )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.7943 0 0 8.9 475.08 290.65 Tm (spC.cifique )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0127 Tc 8.9 0 0 8.9 515.44 290.65 Tm (des )Tj 0.38 0.38 0.372 rg -0.0135 Tc -24.479 -1.079 Td (voies )Tj 0.0019 Tc 2.527 0 Td (acriennes )Tj 0.05 Tc 8.9571 0 0 8.9 357.03 281.05 Tm (et )Tj 0.318 0.318 0.31 rg -0.0202 Tc 8.9 0 0 8.9 366.64 281.05 Tm (du )Tj -0.0066 Tc 1.409 0 Td (VEMS )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0139 Tc 8.9 0 0 8.9 407.4198 281.05 Tm (\(n=20, )Tj EMC /Suspect <>BDC 0.318 0.318 0.31 rg 0.0203 Tc 7.8001 0 0 7.8001 434.89 281.05 Tm (p>BDC /T1_0 1 Tf -0.035 Tc 8.5916 0 0 8.9 344.58 270.97 Tm (Ia )Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0215 Tc 8.9 0 0 8.9 354.16 270.97 Tm (dose )Tj 0.0337 Tc 2.265 0 Td (du )Tj 0.318 0.318 0.31 rg 0.026 Tc 1.412 0 Td (poumon )Tj 0.0024 Tc 3.819 0 Td (droit )Tj 0.05 Tc 8.9571 0 0 8.9 441.51 270.97 Tm (et )Tj 0.247 0.251 0.243 rg 0 Tc 8.9 0 0 8.9 451.61 270.97 Tm (l)Tj 0.38 0.38 0.372 rg -0.0033 Tc 0.321 0 Td (es )Tj 0.318 0.318 0.31 rg 0.0055 Tc 1.248 0 Td (modifications )Tj 0.38 0.38 0.372 rg -0.0202 Tc 5.98 0 Td (du )Tj 0.0181 Tc -24.918 -1.079 Td (calibre )Tj 0.0127 Tc 3.183 0 Td (des )Tj 0.0135 Tc 1.787 0 Td (voies )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0019 Tc 8.9 0 0 8.9 364.2298 261.3669 Tm (aerienncs )Tj EMC ET BT /T1_0 1 Tf 0.0311 Tc 8.9 0 0 8.9 401.7522 261.3669 Tm (nc )Tj 0.247 0.251 0.243 rg 0 Tc 1.396 0 Td (l)Tj 0.38 0.38 0.372 rg 0.267 0 Td (e )Tj 0.05 Tc 8.9303 0 0 8.9 423.71 261.37 Tm (so)Tj 0.247 0.251 0.243 rg -0.0186 Tc 8.9 0 0 8.9 432.47 261.37 Tm (nt )Tj 0.38 0.38 0.372 rg 0.015 Tc 1.189 0 Td (pas. )Tj 0.247 0.251 0.243 rg 0.0379 Tc 2.043 0 Td (La )Tj 0.38 0.38 0.372 rg -0.0012 Tc 1.453 0 Td (distribution )Tj 0.318 0.318 0.31 rg 0.05 Tc 9.2683 0 0 8.9 518.79 261.37 Tm (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0218 Tc 8.9 0 0 8.9 297.31 251.76 Tm (!'aerosol )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg -0.0106 Tc 3.962 0 Td (inha)Tj 0.247 0.251 0.243 rg 0 Tc 1.78 0 Td (l)Tj 0.38 0.38 0.372 rg -0.0261 Tc 0.213 0 Td (e. )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0159 Tc 8.9 0 0 8.9 360.4555 251.76 Tm (mais )Tj 0.0067 Tc 2.266 0 Td (non )Tj -0.035 Tc 7.9307 0 0 8.9 397.87 251.76 Tm (Ia )Tj 0.0076 Tc 8.9 0 0 8.9 407.44 251.76 Tm (dose, )Tj 0.38 0.38 0.372 rg 0.0217 Tc 2.534 0 Td (est )Tj 0.318 0.318 0.31 rg 0.0025 Tc 1.511 0 Td (done )Tj 0.247 0.251 0.243 rg 0 Tc 2.32 0 Td (l)Tj 0.38 0.38 0.372 rg -0.012 Tc 0.375 0 Td (arge)Tj 0.247 0.251 0.243 rg 0 Tc 1.68 0 Td (m)Tj 0.38 0.38 0.372 rg -0.0064 Tc 0.801 0 Td (en)Tj 0.247 0.251 0.243 rg 0 Tc 0.979 0 Td (t )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf -0.0027 Tc 8.9 0 0 8.9 503.916 251.76 Tm (dcpen\255)Tj EMC ET BT 0.38 0.38 0.372 rg /T1_0 1 Tf -0.035 Tc 8.7826 0 0 8.9 297.52 241.69 Tm (dnn)Tj 0.247 0.251 0.243 rg 0 Tc 8.9 0 0 8.9 310.54 241.69 Tm (t)Tj 0.38 0.38 0.372 rg 0.262 0 Td (e )Tj -0.0202 Tc 0.864 0 Td (du )Tj -0.0006 Tc 1.401 0 Td (caJibre )Tj 0.318 0.318 0.31 rg -0.0143 Tc 3.183 0 Td (des )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.5931 0 0 8.9 377.26 241.69 Tm (vo.ies )Tj EMC /Suspect <>BDC 0.38 0.38 0.372 rg -0.0149 Tc 8.9 0 0 8.9 399.62 241.69 Tm (:u!riennes. )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg 0.0379 Tc 4.496 0 Td (Le)Tj 0.38 0.38 0.372 rg 0 Tc 1.124 0 Td (s )Tj EMC ET BT 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0102 Tc 8.9 0 0 8.9 456.4109 241.69 Tm (differences )Tj ET BT /Suspect <>BDC 0.38 0.38 0.372 rg /T1_0 1 Tf 0.0215 Tc 8.9 0 0 8.9 500.0921 241.69 Tm (d'index )Tj EMC ET BT 0.247 0.251 0.243 rg /T1_0 1 Tf 0.05 Tc 9.2683 0 0 8.9 297.03 231.61 Tm (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0154 Tc 8.9 0 0 8.9 308.65 231.61 Tm (penetration )Tj EMC ET BT /T1_0 1 Tf 0.0183 Tc 8.9 0 0 8.9 353.1856 231.61 Tm (entre )Tj -0.0076 Tc 2.429 0 Td (les )Tj 0.0139 Tc 1.503 0 Td (sujets )Tj 0.0106 Tc 2.71 0 Td (normaux )Tj 0.318 0.318 0.31 rg 0.05 Tc 9.5969 0 0 8.9 447.74 231.61 Tm (et )Tj 0.0025 Tc 8.9 0 0 8.9 458.31 231.61 Tm (asthmatiques )Tj 0.247 0.251 0.243 rg 0.0001 Tc 5.674 0 Td (pour\255)Tj 0.0201 Tc -23.787 -1.079 Td (raient )Tj ET BT /Suspect <>BDC 0.318 0.318 0.31 rg /T1_0 1 Tf 0.0113 Tc 8.9 0 0 8.9 322.4604 222.0069 Tm (etre )Tj EMC /Suspect <>BDC 0.247 0.251 0.243 rg 0.0069 Tc 1.996 0 Td (expliquees )Tj EMC ET BT /T1_0 1 Tf -0.0151 Tc 8.9 0 0 8.9 383.4254 222.0069 Tm (au )Tj -0.0144 Tc 1.465 0 Td (rnieux )Tj 0.05 Tc 9.1296 0 0 8.9 422.89 222.01 Tm (par )Tj 0.0396 Tc 8.9 0 0 8.9 439.12 222.01 Tm (des )Tj 0.0048 Tc 1.888 0 Td (differences )Tj 0.0215 Tc 4.962 0 Td (dans )Tj 0.05 Tc 8.9036 0 0 8.9 521.21 222.01 Tm (le )Tj 0.0181 Tc 8.9 0 0 8.9 297.03 211.93 Tm (calibre )Tj 0.0127 Tc 3.183 0 Td (des )Tj 0.0135 Tc 1.733 0 Td (voies )Tj 0.0019 Tc 2.527 0 Td (aeriennes )Tj 0.0057 Tc 4.207 0 Td (centrales. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0173 Tc 9 0 0 9 297.19 201.85 Tm (Eur )Tj EMC ET BT /T1_2 1 Tf 0.0123 Tc 9 0 0 9 313.993 201.85 Tm (Respir )Tj ET BT /Suspect <>BDC /T1_3 1 Tf -0.0251 Tc 8.6 0 0 8.6 340.72 201.85 Tm (J., )Tj EMC ET BT /T1_2 1 Tf -0.035 Tc 9.5211 0 0 9.6 353.11 201.85 Tm (1988, )Tj 0 Tc 9.6 0 0 9.6 376.63 201.85 Tm (1)Tj 0.38 0.38 0.372 rg 0.521 0 Td (, )Tj ET BT /Suspect <>BDC 0.247 0.251 0.243 rg /T1_2 1 Tf -0.035 Tc 8.7716 0 0 9.6 386.78 201.85 Tm (890....S95. )Tj EMC ET endstream endobj 33 0 obj <>stream Hd͊zy8 >sRhF^#y QG#Oç==o/ϧ;c_mӷKv|~_oo~y>}~W=|z>{O݇q~?>Ï?o+~ߒ~;%zΏx߽w;>lp?(O?{wٸ^ PZUuTGu^5P5FjFDMԤU PjVjUmFmک]uPuNNE]E5|| _#_k55|| _#_k55|| _#_k55|| _#_k5Z||-_+_kZ||-_+_kZ||-_+_kZ||-_+_ku:||_'_uu:||_'_uu:||_'_uu:||_'_uz||=_/_z||=_/_z||=_/_z||=_/_ || ߀o77 || ߀o77 || ߀o77 || ߀o77 KG#(~? ?G#(~? ?G#(~? ?G#(~? ?z $߄o77MM&|| $߄o77MM&|| $߄o77MM&|| $߄o77MM&||3,ߌo77f||3,ߌo77f||3,ߌo77f||3,ߌo77f|| "߂oȷ[--|| "߂oȷ[--|| "߂oȷ[--|| "߂oȷ[--||+*ߊoŷʷ[V||+*ߊoŷʷ[V||+*ߊoŷʷ[V||+*ߊoŷʷ[V|| &߆o÷ɷmm6|| &߆o÷ɷmm6|| &߆o÷ɷmm6|| &߆o÷ɷmm6|ۯ\t;]~~߅ww;]~~߅ww;]~~߅ww;]~~߅w߁w;;|C߁w;;|C߁w;;|C߁w;;|C߉w;;NN|'S߉w;;NN|'S߉w;;NN|'S߉w;;NN|'S ߅w]..|K ߅w]..|K ߅w]..|K 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