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9.9 0 0 9.9 125.686 721.21 Tm (The )Tj 0.196 0.196 0.192 rg 0.0089 Tc 1.946 0 Td (remaining )Tj 0.255 0.259 0.255 rg 0 Tc 4.451 0 Td (e)Tj 0.11 0.11 0.106 rg 0.488 0 Td (l)Tj 0.255 0.259 0.255 rg 0.0441 Tc 0.239 0 Td (eve)Tj 0.11 0.11 0.106 rg 0 Tc 1.465 0 Td (n )Tj 0.196 0.196 0.192 rg 0.008 Tc 0.86 0 Td (subjects )Tj 0.0028 Tc 3.593 0 Td (declined )Tj 0.329 g 0 Tc -19.734 -1.067 Td (a )Tj 0.255 0.259 0.255 rg -0.0038 Tc 0.872 0 Td [(further )-174(bronchial )]TJ 0.196 0.196 0.192 rg 0.0019 Tc 7.274 0 Td (challenge. )Tj /T1_2 1 Tf 0.015 Tc 9.8 0 0 9.8 58.64 683.76 Tm (Histamine )Tj 0.0381 Tc 4.639 0 Td (and )Tj 0.011 Tc 1.911 0 Td (methacholine )Tj 0.0112 Tc 5.874 0 Td (challenges )Tj /T1_0 1 Tf 0.0042 Tc 9.9 0 0 9.9 67.61 661.68 Tm (Inhalation )Tj 0.008 Tc 4.652 0 Td (challenges )Tj -0.0152 Tc 4.858 0 Td (were )Tj 0.0021 Tc 2.427 0 Td (performed )Tj 0.0033 Tc 4.739 0 Td (as )Tj 0.0063 Tc 1.321 0 Td (previously )Tj 0.0014 Tc -18.872 -1.067 Td (described )Tj -0.008 Tc 4.373 0 Td (using 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0 Td (a )Tj 0.0035 Tc 0.885 0 Td (pressure )Tj 0.05 Tc 10.5727 0 0 9.9 175.58 629.53 Tm (of )Tj -0.0113 Tc 9.9 0 0 9.9 188.78 629.53 Tm (138 )Tj 0.0267 Tc 1.826 0 Td (kPa )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.1649 0 0 8.8 225.97 629.53 Tm (\(20 )Tj EMC ET BT /T1_0 1 Tf 0.0058 Tc 9.9 0 0 9.9 242.9 629.53 Tm (pounds )Tj 0.0453 Tc 3.248 0 Td (per )Tj 0.255 0.259 0.255 rg 0.0168 Tc -21.883 -1.067 Td (square )Tj 0.11 0.11 0.106 rg 0.0081 Tc 3.109 0 Td (inch\), )Tj 0.196 0.196 0.192 rg 0.0135 Tc 2.761 0 Td (for )Tj 0 Tc 1.649 0 Td (a )Tj -0.0034 Tc 0.922 0 Td (duration )Tj 0.05 Tc 10.5727 0 0 9.9 179.42 618.97 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0161 Tc 9.9 0 0 9.9 192.38 618.97 Tm (0.6 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 209.1407 618.97 Tm (s )Tj -0.0238 Tc 0.876 0 Td (from )Tj 0.11 0.11 0.106 rg -0.0028 Tc 2.433 0 Td (the )Tj 0.196 0.196 0.192 rg 0.0129 Tc 1.636 0 Td (start )Tj 0.05 Tc 10.5727 0 0 9.9 279.26 618.97 Tm (of )Tj -0.0039 Tc 9.9 0 0 9.9 58.96 607.92 Tm (inspiration )Tj 0.05 Tc 10.5727 0 0 9.9 105.98 607.92 Tm (of )Tj 0.0111 Tc 9.9 0 0 9.9 118.93 607.92 Tm (each )Tj -0.0035 Tc 2.388 0 Td (breath. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0143 Tc 9.9 0 0 9.9 174.2314 607.92 Tm (Und)Tj 0.329 g 0 Tc 1.735 0 Td (e)Tj 0.11 0.11 0.106 rg 0.495 0 Td (r )Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf 0.0088 Tc 9.9 0 0 9.9 204.4561 607.92 Tm (these )Tj 0.255 0.259 0.255 rg 0.0084 Tc 2.513 0 Td (conditions )Tj 0.196 0.196 0.192 rg -0.0028 Tc 4.711 0 Td (the )Tj 0.255 0.259 0.255 rg 0.0006 Tc -21.967 -1.067 Td (Hudson )Tj 0.196 0.196 0.192 rg 0.0026 Tc 3.543 0 Td (nebulizer )Tj 0.0067 Tc 4.113 0 Td (delivers )Tj 0.0124 Tc 3.539 0 Td (droplets )Tj 0.0075 Tc 3.644 0 Td (with )Tj 0 Tc 2.173 0 Td (a )Tj 0.11 0.11 0.106 rg 0.022 Tc 0.784 0 Td (mas)Tj 0.255 0.259 0.255 rg 0 Tc 1.685 0 Td (s )Tj 0.196 0.196 0.192 rg 0.0044 Tc 0.739 0 Td (median )Tj 0.004 Tc -20.226 -1.114 Td (aerodynamic )Tj 0.0148 Tc 5.625 0 Td (diameter )Tj 0.05 Tc 10.5727 0 0 9.9 153.02 586.33 Tm (of )Tj -0.0075 Tc 9.9 0 0 9.9 166.22 586.33 Tm (1.6 )Tj ET BT /Suspect <>BDC /C0_0 1 Tf 0 Tc 12.96 0 0 7.2 181.93 586.33 Tm <007E0020>Tj EMC ET BT /T1_0 1 Tf 0.0113 Tc 9.9 0 0 9.9 199.1 586.33 Tm (and )Tj -0.0028 Tc 1.899 0 Td (the )Tj 0.0169 Tc 1.592 0 Td (output )Tj 0.05 Tc 10.0163 0 0 9.9 263.42 586.33 Tm (of )Tj 0.11 0.11 0.106 rg -0.035 Tc 9.7344 0 0 9.9 275.98 586.33 Tm (th)Tj 0.255 0.259 0.255 rg 0 Tc 9.9 0 0 9.9 283.09 586.33 Tm (e )Tj 0.11 0.11 0.106 rg -0.0042 Tc -22.681 -1.115 Td (nebuli)Tj 0.255 0.259 0.255 rg 0.05 Tc 9.9064 0 0 9.9 82.99 575.29 Tm (zer )Tj 0.196 0.196 0.192 rg -0.0195 Tc 9.9 0 0 9.9 99.28 575.29 Tm (is )Tj 0.039 Tc 0.923 0 Td (2.6 )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 6.0394 0 0 9.3 124.89 575.29 Tm (j.J.l )Tj EMC ET BT /T1_0 1 Tf 0.0453 Tc 9.9 0 0 9.9 136.34 575.29 Tm (per )Tj -0.0116 Tc 1.696 0 Td (breath. )Tj 0 Tc 3.05 0 Td (F)Tj 0.329 g 0.576 0 Td (o)Tj 0.196 0.196 0.192 rg 0.0028 Tc 0.535 0 Td (llowing )Tj 0.0049 Tc 3.452 0 Td (baseline )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0133 Tc 9.9 0 0 9.9 264.4658 575.29 Tm (meas\255)Tj EMC ET BT /T1_0 1 Tf 0.0033 Tc 9.9 0 0 9.9 58.5656 564.7267 Tm (urements )Tj 0.05 Tc 10.5727 0 0 9.9 100.7 564.73 Tm (of )Tj 0.0093 Tc 9.9 0 0 9.9 115.06 564.73 Tm (sGaw )Tj 0.0215 Tc 2.873 0 Td (the )Tj 0.255 0.259 0.255 rg 0.008 Tc 1.782 0 Td (subjects )Tj 0.11 0.11 0.106 rg -0.0104 Tc 3.885 0 Td (inhal)Tj 0.255 0.259 0.255 rg -0.002 Tc 1.985 0 Td (ed )Tj 0.196 0.196 0.192 rg 0 Tc 1.548 0 Td (5 )Tj 0.0056 Tc 1.082 0 Td (breaths )Tj 0.05 Tc 10.0163 0 0 9.9 279.74 564.73 Tm (of )Tj 0.0098 Tc 9.9 0 0 9.9 58.1 553.68 Tm (phosphate )Tj 0.0026 Tc 4.751 0 Td (buffered )Tj 0.0047 Tc 4.058 0 Td (saline )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0002 Tc 9.9 0 0 9.9 175.0883 553.68 Tm (\(PBS\) )Tj EMC ET BT /T1_0 1 Tf 0.0033 Tc 9.9 0 0 9.9 205.3526 553.68 Tm (as )Tj 0 Tc 1.503 0 Td (a )Tj -0.0008 Tc 1.067 0 Td (control. )Tj 0.0016 Tc 3.737 0 Td (Each )Tj 0.0052 Tc -21.19 -1.067 Td (inhalation )Tj 0.255 0.259 0.255 rg 0.005 Tc 4.406 0 Td (started )Tj 0.0183 Tc 2.962 0 Td (at )Tj -0.005 Tc 1.114 0 Td (functional )Tj 0.196 0.196 0.192 rg 0 Tc 4.422 0 Td (r)Tj 0.329 g 0.012 Tc 0.281 0 Td (es)Tj 0.196 0.196 0.192 rg -0.0244 Tc 0.876 0 Td (idu)Tj 0.329 g 0 Tc 1.259 0 Td (a)Tj 0.196 0.196 0.192 rg 0.535 0 Td (l )Tj 0.329 g 0.0056 Tc 0.483 0 Td (capacity )Tj -0.0129 Tc 3.733 0 Td (and )Tj ET BT /Suspect <>BDC 0.196 0.196 0.192 rg /T1_0 1 Tf -0.0087 Tc 9.9 0 0 9.9 274.0784 543.1167 Tm (ter\255)Tj EMC ET BT /T1_0 1 Tf 0.006 Tc 9.9 0 0 9.9 58.0802 532.5534 Tm (minated )Tj 0.05 Tc 10.1194 0 0 9.9 93.02 532.56 Tm (at )Tj 0.0075 Tc 9.9 0 0 9.9 103.1 532.56 Tm (approximat)Tj 0.329 g 0 Tc 4.557 0 Td (e)Tj 0.11 0.11 0.106 rg 0.536 0 Td (l)Tj 0.329 g 0.298 0 Td (y )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf 0.05 Tc 9.0548 0 0 8.8 164.06 532.56 Tm (70% )Tj EMC ET BT 0.329 g /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 184.7 532.56 Tm (o)Tj 0.196 0.196 0.192 rg 0.532 0 Td (f )Tj -0.0122 Tc 0.594 0 Td (ba)Tj 0.329 g 0.0241 Tc 0.906 0 Td (seline )Tj 0.255 0.259 0.255 rg -0.035 Tc 8.5912 0 0 9.9 231.82 532.56 Tm (vit.aJ )Tj 0.329 g -0.0054 Tc 9.9 0 0 9.9 251.9 532.56 Tm (capac)Tj 0.196 0.196 0.192 rg -0.0019 Tc 2.281 0 Td (ity; )Tj 0 Tc -21.869 -1.114 Td (a )Tj 0.255 0.259 0.255 rg /T1_2 1 Tf 11 0 0 11 66.13 521.53 Tm (5 )Tj /T1_0 1 Tf 9.9 0 0 9.9 74.26 521.53 Tm (s )Tj 0.196 0.196 0.192 rg 0.007 Tc 0.742 0 Td (breath )Tj 0.0069 Tc 2.907 0 Td (hold )Tj 0.329 g -0.0233 Tc 2.182 0 Td (was )Tj 0.255 0.259 0.255 rg -0.0023 Tc 1.938 0 Td (maintained )Tj 0.0183 Tc 4.84 0 Td (at )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0028 Tc 9.9 0 0 9.9 209.7316 521.53 Tm (the )Tj EMC ET BT 0.329 g /T1_0 1 Tf 0.0156 Tc 9.9 0 0 9.9 224.9974 521.53 Tm (end )Tj 0.05 Tc 11.1292 0 0 9.9 242.77 521.53 Tm (of )Tj -0.0051 Tc 9.9 0 0 9.9 254.77 521.53 Tm (each )Tj ET BT /Suspect <>BDC 0.11 0.11 0.106 rg /T1_0 1 Tf -0.0136 Tc 9.9 0 0 9.9 276.8767 521.53 Tm (in\255)Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf -0.0026 Tc 9.9 0 0 9.9 58.0669 510.4915 Tm (halation. )Tj 0.0275 Tc 3.873 0 Td (If )Tj -0.0028 Tc 0.975 0 Td (the )Tj 0.009 Tc 1.496 0 Td (decrease )Tj -0.0336 Tc 3.831 0 Td (in )Tj 0.255 0.259 0.255 rg 0.0255 Tc 1.061 0 Td (sGaw )Tj 0.196 0.196 0.192 rg 0.001 Tc 2.68 0 Td (was )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0133 Tc 9.9 0 0 9.9 214.0315 510.4915 Tm (<10% )Tj EMC ET BT /T1_0 1 Tf -0.0028 Tc 9.9 0 0 9.9 241.4248 510.4915 Tm (the )Tj 0.0009 Tc 1.556 0 Td (patients )Tj -20.076 -1.067 Td (were )Tj 0.255 0.259 0.255 rg 0.0104 Tc 2.314 0 Td (subjected )Tj 0.196 0.196 0.192 rg 0.0011 Tc 4.23 0 Td (to )Tj 0.006 Tc 1.165 0 Td (histamine )Tj 0.05 Tc 10.0163 0 0 9.9 177.02 499.93 Tm (or )Tj 0.11 0.11 0.106 rg 0.0106 Tc 9.9 0 0 9.9 189.1 499.93 Tm (methach)Tj 0.255 0.259 0.255 rg 0.0149 Tc 3.434 0 Td (oline )Tj 0.196 0.196 0.192 rg 0.0073 Tc 2.376 0 Td (challenge. )Tj 0.0033 Tc 6.402 25.599 Td (Two-fold )Tj 0.0036 Tc 4.412 0 Td (increasing )Tj 0.0085 Tc 4.701 0 Td (concentrations )Tj 0.05 Tc 11.1292 0 0 9.9 464.05 753.36 Tm (of )Tj 0.006 Tc 9.9 0 0 9.9 478.55 753.36 Tm (histamine )Tj -0.0012 Tc 4.5 0 Td (acid )Tj 0.11 0.11 0.106 rg 0.006 Tc -21.515 -1.067 Td (pho)Tj 0.255 0.259 0.255 rg 0.0086 Tc 1.487 0 Td (sphate )Tj 0.196 0.196 0.192 rg 0.05 Tc 10.0163 0 0 9.9 357.5 742.8 Tm (or )Tj 0.11 0.11 0.106 rg 0 Tc 9.9 0 0 9.9 373.42 742.8 Tm (m)Tj 0.255 0.259 0.255 rg 0.027 Tc 0.767 0 Td (et)Tj 0.11 0.11 0.106 rg 0 Tc 0.786 0 Td (hacholine )Tj 0.196 0.196 0.192 rg 0.0132 Tc 4.645 0 Td (chloride )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0057 Tc 9.9 0 0 9.9 475.5583 742.8 Tm (\(Sigma, )Tj EMC /Suspect <>BDC 0.0118 Tc 3.887 0 Td (Poole, )Tj EMC ET BT /T1_0 1 Tf -0.0038 Tc 9.9 0 0 9.9 310.0303 731.7615 Tm (Dorset\) )Tj -0.0002 Tc 3.39 0 Td (diluted )Tj -0.0336 Tc 3.201 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0086 Tc 9.9 0 0 9.9 386.8444 731.7615 Tm (PBS )Tj EMC ET BT /T1_0 1 Tf 0.0171 Tc 9.9 0 0 9.9 408.4759 731.7615 Tm (were )Tj 0.0056 Tc 2.417 0 Td (inhaled )Tj -0.0238 Tc 3.391 0 Td (from )Tj 0 Tc 2.28 0 Td (a )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0167 Tc 9.9 0 0 9.9 497.1898 731.7615 Tm (conce)Tj 0.11 0.11 0.106 rg 0.0006 Tc 2.385 0 Td (ntra)Tj 0.255 0.259 0.255 rg 0 Tc 1.589 0 Td (\255)Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf -0.0162 Tc 9.9 0 0 9.9 310.0699 721.2081 Tm (tion )Tj 0.05 Tc 10.5727 0 0 9.9 328.7 721.21 Tm (of )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 10.7568 0 0 11 340.13 721.21 Tm (0.5 )Tj EMC /Suspect <>BDC 0.11 0.11 0.106 rg /T1_0 1 Tf -0.0119 Tc 9.9 0 0 9.9 356.62 721.21 Tm (mg)Tj 0.255 0.259 0.255 rg -0.0147 Tc 1.29 0 Td (\267m)Tj 0.11 0.11 0.106 rg -0.035 Tc 9.0614 0 0 9.9 379.6 721.21 Tm (l\267)Tj 0.255 0.259 0.255 rg 0 Tc 9.9 0 0 9.9 385.33 721.21 Tm (' )Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf -0.0042 Tc 9.9 0 0 9.9 391.5571 721.21 Tm (\(1.6 )Tj 0.0354 Tc 1.95 0 Td (mM )Tj 0.0355 Tc 1.98 0 Td (and )Tj 0.0148 Tc 1.846 0 Td (2.6 )Tj -0.0103 Tc 1.653 0 Td (mM, )Tj 0.11 0.11 0.106 rg 0.0001 Tc 2.28 0 Td (re)Tj 0.255 0.259 0.255 rg 0.0055 Tc 0.763 0 Td (spectively\) )Tj 0.196 0.196 0.192 rg 0.0011 Tc -18.703 -1.115 Td (to )Tj -0.0317 Tc 1.131 0 Td (1.6 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0225 Tc 9.9 0 0 9.9 335.5033 710.1715 Tm (mg-ml)Tj 0.329 g 0 Tc 2.608 0 Td (-)Tj 0.196 0.196 0.192 rg 6.2 0 0 6.2 364.11 713.53 Tm (1 )Tj EMC ET BT /T1_0 1 Tf -0.0267 Tc 9.9 0 0 9.9 370.44 710.17 Tm (\(54)Tj 0 g 0 Tc 1.3 0 Td (.)Tj 0.196 0.196 0.192 rg 0.258 0 Td (2 )Tj 0.11 0.11 0.106 rg 0.0354 Tc 0.78 0 Td (mM )Tj 0.196 0.196 0.192 rg 0.0113 Tc 1.98 0 Td (and )Tj 0.0048 Tc 1.738 0 Td (83)Tj 0.329 g 0 Tc 1.063 0 Td (.)Tj 0.196 0.196 0.192 rg 0.209 0 Td (2 )Tj 0.0139 Tc 0.828 0 Td (mM, )Tj 0.11 0.11 0.106 rg 0.0001 Tc 2.231 0 Td (re)Tj 0.255 0.259 0.255 rg 0.0055 Tc 0.763 0 Td (spectively\) )Tj 0.196 0.196 0.192 rg -0.0108 Tc 4.755 0 Td (for )Tj 0.255 0.259 0.255 rg 0.008 Tc -22.06 -1.116 Td [(asthmatic )-148(subjects )]TJ 0.196 0.196 0.192 rg 0.0113 Tc 8 0 Td (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 407.9412 699.1216 Tm (2)Tj 0.329 g 0.518 0 Td (.)Tj 0.196 0.196 0.192 rg 0.205 0 Td (0 )Tj EMC /Suspect <>BDC 0.0068 Tc 0.978 0 Td (mg\267ml\267)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 453.4 702.48 Tm (1 )Tj EMC ET BT /T1_0 1 Tf -0.0042 Tc 9.9 0 0 9.9 461.64 699.12 Tm (\(6.5 )Tj 0.0354 Tc 2.046 0 Td (mM )Tj -0.0129 Tc 2.125 0 Td (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0074 Tc 9.9 0 0 9.9 522.3765 699.12 Tm (10)Tj 0.329 g 0 Tc 0.983 0 Td (.)Tj 0.196 0.196 0.192 rg 0.209 0 Td (2 )Tj EMC ET BT /T1_0 1 Tf -0.0346 Tc 9.9 0 0 9.9 310.0611 688.5567 Tm (mM, )Tj 0.0025 Tc 2.134 0 Td (respectively\) )Tj 0.11 0.11 0.106 rg 0.0011 Tc 5.478 0 Td (to )Tj 0.196 0.196 0.192 rg 0.0176 Tc 1.008 0 Td (6.4 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0104 Tc 9.9 0 0 9.9 410.8629 688.5567 Tm (mg\267ml)Tj 0.329 g 0 Tc 2.608 0 Td (-)Tj 6.4001 0 0 6.4001 439.46 691.92 Tm (1 )Tj EMC /Suspect <>BDC 0.196 0.196 0.192 rg -0.0067 Tc 9.9 0 0 9.9 445.32 688.56 Tm (\(208 )Tj EMC ET BT /T1_0 1 Tf 0.0354 Tc 9.9 0 0 9.9 466.5357 688.56 Tm (mM )Tj 0.0113 Tc 1.931 0 Td (and )Tj 0.02 Tc 1.695 0 Td (324 )Tj 0.11 0.11 0.106 rg -0.0103 Tc 1.804 0 Td (mM, )Tj 0.196 0.196 0.192 rg 0.004 Tc -21.284 -1.114 Td (respectiv)Tj 0.329 g 0 Tc 3.626 0 Td (e)Tj 0.11 0.11 0.106 rg -0.0345 Tc 0.488 0 Td (ly)Tj 0.255 0.259 0.255 rg 0 Tc 0.729 0 Td (\) )Tj 0.196 0.196 0.192 rg -0.0108 Tc 1.159 0 Td (for )Tj -0.0029 Tc 1.95 0 Td (normal )Tj 0.255 0.259 0.255 rg 0.006 Tc 3.623 0 Td (subjects. )Tj 0.196 0.196 0.192 rg 0.0085 Tc 4.36 0 Td (Specific )Tj 0.0012 Tc 4.129 0 Td (airways )Tj 0.255 0.259 0.255 rg 0.007 Tc -20.073 -1.116 Td (conductance )Tj 0.196 0.196 0.192 rg 0.0069 Tc 5.38 0 Td (\(sGaw\) )Tj 0.001 Tc 3.357 0 Td [(was )-129(measured )]TJ 0 Tc 6.153 0 Td (2 )Tj 0.001 Tc 0.877 0 Td (min )Tj 0.0182 Tc 1.883 0 Td (after )Tj 0.255 0.259 0.255 rg -0.0001 Tc 2.229 0 Td (eac)Tj 0.11 0.11 0.106 rg 0 Tc 1.368 0 Td (h )Tj ET BT /Suspect <>BDC 0.196 0.196 0.192 rg /T1_0 1 Tf -0.035 Tc 9.8452 0 0 9.9 528.4 666.48 Tm (in\255)Tj EMC ET BT /T1_0 1 Tf -0.0019 Tc 9.9 0 0 9.9 309.59 655.92 Tm (halation )Tj 0.0113 Tc 3.482 0 Td (and )Tj 0.009 Tc 1.699 0 Td (increasing )Tj 0.0085 Tc 4.41 0 Td (concentrations )Tj 0.0171 Tc 6.167 0 Td (were )Tj -0.0008 Tc 2.27 0 Td (administered )Tj 0.003 Tc -18.026 -1.114 Td (until )Tj -0.0068 Tc 2.119 0 Td (sGaw )Tj -0.0165 Tc 2.583 0 Td (had )Tj -0.0027 Tc 1.687 0 Td (fallen )Tj 0.0278 Tc 2.582 0 Td (by )Tj 0.0121 Tc 1.306 0 Td (more )Tj 0.0093 Tc 2.327 0 Td (than )Tj 0.0129 Tc 2.026 0 Td (35%. )Tj 0.0317 Tc 2.38 0 Td (The )Tj 0.0066 Tc 1.84 0 Td (coefficient )Tj 0.329 g 0 Tc -18.861 -1.067 Td (o)Tj 0.196 0.196 0.192 rg 0.532 0 Td (f )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf -0.0067 Tc 9.9 0 0 9.9 322.0541 634.3281 Tm (variation )Tj EMC ET BT /T1_0 1 Tf -0.0108 Tc 9.9 0 0 9.9 361.8026 634.3281 Tm (for )Tj ET BT /Suspect <>BDC 0.196 0.196 0.192 rg /T1_0 1 Tf -0.035 Tc 9.7548 0 0 9.9 377.27 634.33 Tm (hi)Tj 0.329 g -0.0011 Tc 9.9 0 0 9.9 384.82 634.33 Tm (stami)Tj 0.196 0.196 0.192 rg 0 Tc 2.243 0 Td (n)Tj 0.329 g 0.426 0 Td (e )Tj EMC ET BT /T1_0 1 Tf 9.9 0 0 9.9 419.8957 634.33 Tm (a)Tj 0.196 0.196 0.192 rg -0.035 Tc 9.4833 0 0 9.9 424.79 634.33 Tm (nd )Tj 0 Tc 9.9 0 0 9.9 438.7 634.33 Tm (m)Tj 0.329 g 0.0109 Tc 0.767 0 Td (ethacho)Tj 0.196 0.196 0.192 rg 0 Tc 3.203 0 Td (l)Tj 0.329 g 0.0041 Tc 0.291 0 Td (ine )Tj 0.196 0.196 0.192 rg 0.0026 Tc 1.598 0 Td (challenges )Tj 0 Tc -18.9 -1.068 Td (h)Tj 0.329 g 0.0033 Tc 0.476 0 Td (as )Tj 0.255 0.259 0.255 rg 0.0018 Tc 1.224 0 Td (previou)Tj 0.408 g 0 Tc 3.038 0 Td (s)Tj 0.196 0.196 0.192 rg 0.442 0 Td (l)Tj 0.329 g 0.25 0 Td (y )Tj 0.255 0.259 0.255 rg -0.0113 Tc 0.826 0 Td (been )Tj 0.329 g 0.0081 Tc 2.215 0 Td (shown )Tj 0.196 0.196 0.192 rg 0 Tc 3.018 0 Td (t)Tj 0.329 g 0.234 0 Td (o )Tj 0.255 0.259 0.255 rg 0.0363 Tc 0.884 0 Td (be )Tj 0.11 0.11 0.106 rg 0 Tc 1.419 0 Td (1)Tj 0.329 g 0.0103 Tc 0.36 0 Td (5% )Tj 0.196 0.196 0.192 rg -0.035 Tc 9.2582 0 0 9.9 469.36 623.76 Tm (in )Tj 0.255 0.259 0.255 rg 0.0046 Tc 9.9 0 0 9.9 480.46 623.76 Tm (this )Tj 0.11 0.11 0.106 rg -0.002 Tc 1.788 0 Td (laboratory )Tj 0.329 g 0 Tc 8.8 0 0 8.8 309.87 613.21 Tm ([ )Tj ET BT /Suspect <>BDC 0.196 0.196 0.192 rg /T1_0 1 Tf 8.8 0 0 8.8 314.1028 613.21 Tm (1)Tj 0.329 g 0.0497 Tc 0.405 0 Td (3\). )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.8674 0 0 9.9 333.1 613.21 Tm (As)Tj 0.196 0.196 0.192 rg 9.7189 0 0 9.9 344.14 613.21 Tm (thm)Tj 0.329 g 0.05 Tc 10.1194 0 0 9.9 358.94 613.21 Tm (at)Tj 0.196 0.196 0.192 rg 0 Tc 9.9 0 0 9.9 366.64 613.21 Tm (i)Tj 0.408 g 0.24 0 Td [(c )-175(s)]TJ 0.196 0.196 0.192 rg 1.319 0 Td (u)Tj 0.329 g -0.0016 Tc 0.486 0 Td (bjec)Tj 0.196 0.196 0.192 rg 0 Tc 1.645 0 Td (t)Tj 0.408 g 0.23 0 Td (s )Tj 0.255 0.259 0.255 rg 0.0055 Tc 0.888 0 Td (bronchoconstrict )Tj 0.0183 Tc 7.213 0 Td (at )Tj ET BT /Suspect <>BDC 0.196 0.196 0.192 rg /T1_0 1 Tf 0.008 Tc 9.9 0 0 9.9 496.6864 613.21 Tm (concentra\255)Tj EMC ET BT /T1_0 1 Tf -0.0003 Tc 9.9 0 0 9.9 309.5665 602.1715 Tm (tions )Tj 0.05 Tc 10.5727 0 0 9.9 332.06 602.17 Tm (of )Tj 0.11 0.11 0.106 rg 0 Tc 9.9 0 0 9.9 344.56 602.17 Tm (l)Tj 0.255 0.259 0.255 rg 0.0054 Tc 0.239 0 Td (ess )Tj 0.11 0.11 0.106 rg -0.0069 Tc 1.609 0 Td (than )Tj ET BT /Suspect <>BDC 0.196 0.196 0.192 rg /T1_0 1 Tf 0.0161 Tc 9.9 0 0 9.9 383.4175 602.17 Tm (0.8 )Tj EMC /Suspect <>BDC 0.11 0.11 0.106 rg 0 Tc 1.657 0 Td (m)Tj 0.255 0.259 0.255 rg -0.0215 Tc 0.77 0 Td (g\267ml-)Tj 0 Tc 6.4001 0 0 6.4001 428.42 605.53 Tm (1)Tj 0.11 0.11 0.106 rg 0.539 -0.525 Td (. )Tj EMC /Suspect <>BDC 0.196 0.196 0.192 rg /T1_2 1 Tf 0.0208 Tc 9.8 0 0 9.8 309.22 575.29 Tm (LTE)Tj /T1_3 1 Tf 0 Tc 6.5001 0 0 6.5001 325.84 571.92 Tm (4 )Tj EMC ET BT /T1_2 1 Tf 0.008 Tc 9.8 0 0 9.8 333 575.29 Tm (inhalation )Tj 0.255 0.259 0.255 rg 0.0166 Tc 4.657 0 Td (challenges )Tj 0.196 0.196 0.192 rg /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 317.71 553.68 Tm (L )Tj 0.05 Tc 10.3387 0 0 9.9 323.43 553.68 Tm (TE)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 335.98 550.33 Tm (4 )Tj /T1_0 1 Tf 0.001 Tc 9.9 0 0 9.9 343.19 553.68 Tm (was )Tj 0.0076 Tc 1.894 0 Td (prepared )Tj 0.0278 Tc 3.878 0 Td (by )Tj 0.0056 Tc 1.355 0 Td (total )Tj 0.255 0.259 0.255 rg 0.0146 Tc 2.125 0 Td (chemical )Tj 0.0058 Tc 4.02 0 Td (synthesis )Tj 0.196 0.196 0.192 rg -0.035 Tc 9.7717 0 0 9.9 514.94 553.68 Tm (as )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0032 Tc 9.9 0 0 9.9 525.99 553.68 Tm (de\255)Tj EMC ET BT 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0082 Tc 9.9 0 0 9.9 308.982 543.1167 Tm (scribed )Tj 0.196 0.196 0.192 rg 0.0009 Tc 3.216 0 Td (previously )Tj -0.0102 Tc 4.58 0 Td ([14] )Tj 0.0113 Tc 1.954 0 Td (and )Tj -0.01 Tc 1.793 0 Td (frozen )Tj 0.013 Tc 2.872 0 Td (under )Tj -0.0087 Tc 2.608 0 Td (argon )Tj 0.05 Tc 10.1194 0 0 9.9 502.94 543.12 Tm (at )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0407 Tc 8.8 0 0 8.8 513.5 543.12 Tm (-70"C. )Tj EMC ET BT 0.11 0.11 0.106 rg /T1_0 1 Tf 0.0123 Tc 9.9 0 0 9.9 309.07 532.56 Tm (LTE)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 326.86 528.73 Tm (4 )Tj 0.196 0.196 0.192 rg /T1_0 1 Tf 0.001 Tc 9.9 0 0 9.9 338.39 532.56 Tm (was )Tj 0.0079 Tc 2.27 0 Td (analysed )Tj 0.0055 Tc 4.278 0 Td (before )Tj 0.0052 Tc 3.336 0 Td (inhalation )Tj 0.0091 Tc 4.749 0 Td (challenge )Tj -0.0207 Tc 4.617 0 Td (by )Tj 0.0042 Tc -22.208 -1.114 Td (reverse )Tj 0.0032 Tc 3.348 0 Td (phase )Tj 0.11 0.11 0.106 rg -0.035 Tc 9.7548 0 0 9.9 369.11 521.53 Tm (hi)Tj 0.329 g 0 Tc 9.9 0 0 9.9 376.72 521.53 Tm (g)Tj 0.196 0.196 0.192 rg 0.54 0 Td (h )Tj 0.01 Tc 0.876 0 Td (performance )Tj 0.012 Tc 5.566 0 Td (liquid )Tj 0.005 Tc 2.762 0 Td (chromatography )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0055 Tc 9.9 0 0 9.9 309.004 510.4915 Tm (\(RP-HPLC\) )Tj EMC ET BT /T1_0 1 Tf 0.0386 Tc 9.9 0 0 9.9 361.3453 510.4915 Tm (on )Tj 0 Tc 1.503 0 Td (a )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0411 Tc 9.9 0 0 9.9 386.0656 510.4915 Tm (10 )Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf -0.0027 Tc 9.9 0 0 9.9 401.2621 510.4915 Tm (micron )Tj 0 Tc 3.289 0 Td (C)Tj -0.035 Tc 6.4459 0 0 6.7 441.38 507.12 Tm (18 )Tj ET BT /Suspect <>BDC 0.11 0.11 0.106 rg /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 452.64 510.49 Tm (u)Tj 0.255 0.259 0.255 rg -0.0033 Tc 0.574 0 Td (ltrasil-ODS )Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf 0.0155 Tc 9.9 0 0 9.9 508.7037 510.49 Tm (column )Tj -0.035 Tc 9.8576 0 0 9.9 309.48 499.93 Tm (\(4)Tj 0.329 g 0 Tc 9.9 0 0 9.9 318.03 499.93 Tm (.)Tj 0.196 0.196 0.192 rg 0.203 0 Td (6 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0352 Tc 9.9 0 0 9.9 330.6624 499.93 Tm (250 )Tj EMC ET BT /T1_0 1 Tf -0.0163 Tc 9.9 0 0 9.9 348.9378 499.93 Tm (mm; )Tj 0.0133 Tc 2.131 0 Td (Beckman )Tj 0.11 0.11 0.106 rg -0.035 Tc 9.8048 0 0 9.9 411.29 499.93 Tm (In)Tj 0.255 0.259 0.255 rg 0 Tc 9.9 0 0 9.9 419.86 499.93 Tm (s)Tj 0.11 0.11 0.106 rg -0.0004 Tc 0.4 0 Td (truments )Tj 0.0059 Tc 3.825 0 Td (In)Tj 0.255 0.259 0.255 rg 0.0058 Tc 0.87 0 Td (c, )Tj 0.196 0.196 0.192 rg 0.0117 Tc 0.976 0 Td (Berkeley, )Tj -0.0012 Tc 4.212 0 Td (CA\) )Tj /T1_1 1 Tf 0.005 Tc 9 0 0 9 73.86 478.81 Tm (Table )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0 Tc 9 0 0 9 100.509 478.81 Tm (1)Tj 0.329 g 0.539 0 Td (. )Tj EMC ET BT 0.196 0.196 0.192 rg /T1_1 1 Tf 9 0 0 9 110.319 478.81 Tm (-)Tj -0.0011 Tc 1.016 0 Td (The )Tj 0.0076 Tc 2.077 0 Td (doses )Tj 0.0414 Tc 3.041 0 Td (of )Tj -0.0196 Tc 1.268 0 Td (LTE)Tj /T1_0 1 Tf 0 Tc 6.4001 0 0 6.4001 192.94 475.44 Tm (4 )Tj /T1_1 1 Tf -0.0223 Tc 9 0 0 9 200.07 478.81 Tm (and )Tj -0.0045 Tc 2.071 0 Td (methacho)Tj 0.329 g 0.0229 Tc 4.373 0 Td (li)Tj 0.196 0.196 0.192 rg -0.035 Tc 8.7993 0 0 9 262.39 478.81 Tm (ne )Tj -0.0223 Tc 9 0 0 9 275.43 478.81 Tm (and )Tj -0.0097 Tc 2.071 0 Td (histamine )Tj -0.0116 Tc 4.606 0 Td (which )Tj 0.0033 Tc 2.914 0 Td (produced )Tj 0 Tc 4.596 0 Td (a )Tj -0.0008 Tc 0.904 0 Td (35% )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0015 Tc 9 0 0 9 432.462 478.81 Tm (fall )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 8.8795 0 0 9 448.15 478.81 Tm (in )Tj 0.0086 Tc 9 0 0 9 458.32 478.81 Tm (sGaw )Tj -0.0193 Tc 2.978 0 Td (\(PD)Tj /T1_0 1 Tf 0.05 Tc 6.6332 0 0 6.4001 500.56 475.44 Tm (35)Tj 0 Tc 6.4001 0 0 6.4001 507.32 478.81 Tm (\) )Tj /T1_1 1 Tf -0.035 Tc 8.8795 0 0 9 513.43 478.81 Tm (in )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0058 Tc 9 0 0 9 74.23 468.72 Tm (normal )Tj EMC ET BT /T1_1 1 Tf -0.0223 Tc 9 0 0 9 105.514 468.72 Tm (and )Tj 0.0016 Tc 2.08 0 Td (asthmatic )Tj -0.0028 Tc 4.694 0 Td (subjects )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0123 Tc 8.8 0 0 8.8 73.76 448.56 Tm (Subjects )Tj EMC /Suspect <>BDC 0.0464 Tc 7.65 0.056 Td (PD)Tj /T1_1 1 Tf -0.035 Tc 5.9381 0 0 6 152.57 445.21 Tm (35)Tj /T1_0 1 Tf 0.0184 Tc 8.8 0 0 8.8 158.83 449.05 Tm (LTE)Tj /T1_1 1 Tf 0 Tc 6 0 0 6 175.18 445.21 Tm (4 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.0464 Tc 8.8 0 0 8.8 200.6 449.05 Tm (PD)Tj 0.0274 Tc 6.3001 0 0 6.3001 212.09 445.21 Tm (35 )Tj EMC ET BT /T1_0 1 Tf 0.0174 Tc 8.8 0 0 8.8 222.68 449.05 Tm (Methacholine )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0464 Tc 8.8 0 0 8.8 288.4424 449.05 Tm (PD)Tj 0.0274 Tc 6.3001 0 0 6.3001 299.93 445.21 Tm (35 )Tj EMC ET BT /T1_0 1 Tf 0.0083 Tc 8.8 0 0 8.8 309.56 449.05 Tm (Histamin)Tj 0.329 g 0 Tc 3.703 0 Td (e )Tj 0.196 0.196 0.192 rg 0.0083 Tc 3.388 0 Td (Relative )Tj 0.0115 Tc 3.764 0 Td (Potency )Tj 0.0083 Tc 6 0.055 Td (Relative )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0115 Tc 8.8 0 0 8.8 491.4824 449.534 Tm (Potency )Tj EMC ET BT /T1_0 1 Tf 0.0184 Tc 8.8 0 0 8.8 367.156 439.4404 Tm (LTE )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0465 Tc 8.8 0 0 8.8 383.524 439.4404 Tm (/Methacholine )Tj EMC /Suspect <>BDC 0.0113 Tc 8.613 0 Td (LTE.JHistamine )Tj EMC ET BT /T1_0 1 Tf 0.014 Tc 8.8 0 0 8.8 73.8344 428.8892 Tm (asthmatic )Tj 0.042 Tc 8.6 0 0 8.6 150.23 428.89 Tm (nmol )Tj ET BT /Suspect <>BDC /C0_0 1 Tf 0 Tc 4.8 0 0 7.2 226.57 428.41 Tm <007E006D006F006C0020>Tj EMC /Suspect <>BDC 4.68 0 0 6.72 307.68 428.89 Tm <007E006D006F006C0020>Tj EMC ET BT 0.255 0.259 0.255 rg /T1_0 1 Tf 8.8 0 0 8.8 87.54 409.21 Tm (1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.023 Tc 8.8 0 0 8.8 159.3128 409.21 Tm (2.90 )Tj EMC /Suspect <>BDC 0.196 0.196 0.192 rg 0.0057 Tc 8.232 0 Td (0.76 )Tj EMC /Suspect <>BDC 0.0131 Tc 9.218 0 Td (0.9 )Tj EMC ET BT /T1_0 1 Tf -0.0042 Tc 8.8 0 0 8.8 393.5512 409.694 Tm (261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0321 Tc 8.8 0 0 8.8 484.2176 409.694 Tm (309 )Tj EMC ET BT 0.255 0.259 0.255 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 86.8272 399.1252 Tm (2 )Tj ET BT /Suspect <>BDC 0.196 0.196 0.192 rg /T1_0 1 Tf -0.0013 Tc 8.8 0 0 8.8 155.2208 399.1252 Tm (16)Tj 0.329 g 0 Tc 1.05 0 Td (.)Tj 0.196 0.196 0.192 rg 0.05 Tc 8.8682 0 0 8.8 165.99 399.12 Tm (00 )Tj EMC /Suspect <>BDC 0.042 Tc 8.8 0 0 8.8 231.27 399.12 Tm (0.70 )Tj EMC /Suspect <>BDC -0.0142 Tc 9.273 0 Td (0.7 )Tj EMC ET BT /T1_1 1 Tf 0.032 Tc 8.1 0 0 8.1 397.89 399.61 Tm (44 )Tj 0.255 0.259 0.255 rg /T1_0 1 Tf 0.05 Tc 8.8142 0 0 8.8 488.6 399.61 Tm (45 )Tj 0.196 0.196 0.192 rg 0 Tc 8.8 0 0 8.8 86.78 389.05 Tm (3 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0399 Tc 8.8 0 0 8.8 158.8432 389.05 Tm (4.00 )Tj EMC /Suspect <>BDC 0.255 0.259 0.255 rg -0.0125 Tc 8.231 0 Td (0.51 )Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf 0.039 Tc 8.8 0 0 8.8 312.4384 389.05 Tm (2.2 )Tj -0.0052 Tc 9.299 0.055 Td (127 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.8901 0 0 8.8 484.2 389.53 Tm (550 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 86.36 379.44 Tm (4 )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0249 Tc 8.8 0 0 8.8 159.268 379.44 Tm (7.00 )Tj EMC /Suspect <>BDC 0.196 0.196 0.192 rg 0.0239 Tc 8.182 0 Td (0.26 )Tj EMC ET BT /T1_0 1 Tf 0.0117 Tc 8.8 0 0 8.8 312.432 379.44 Tm (2.6 )Tj 0.255 0.259 0.255 rg 0.05 Tc 9.0021 0 0 8.8 397.82 379.44 Tm (36 )Tj 0.196 0.196 0.192 rg 0.0048 Tc 8.8 0 0 8.8 484.22 379.93 Tm (371 )Tj /T1_2 1 Tf 0 Tc 9.3 0 0 9.3 86.79 369.37 Tm (5 )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0281 Tc 8.8 0 0 8.8 159.24 369.37 Tm (5.20 )Tj EMC /Suspect <>BDC 0.196 0.196 0.192 rg 0.0057 Tc 8.185 0 Td (0.23 )Tj EMC /Suspect <>BDC 0.0131 Tc 9.218 0 Td (0.3 )Tj EMC ET BT /T1_1 1 Tf 0.032 Tc 8.1 0 0 8.1 397.89 369.84 Tm (44 )Tj /T1_0 1 Tf -0.035 Tc 8.7667 0 0 8.8 489 369.84 Tm (51 )Tj 0 Tc 8.8 0 0 8.8 86.77 359.28 Tm (6 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.025 Tc 8.8 0 0 8.8 159.2644 359.28 Tm (9.00 )Tj EMC /Suspect <>BDC 0.0239 Tc 8.183 0 Td (0.32 )Tj EMC /Suspect <>BDC 0.0403 Tc 9.218 0 Td (0.4 )Tj EMC ET BT 0.255 0.259 0.255 rg /T1_0 1 Tf 0.05 Tc 9.0021 0 0 8.8 397.82 359.28 Tm (36 )Tj 0.196 0.196 0.192 rg 8.8142 0 0 8.8 488.6 359.76 Tm (45 )Tj 0 Tc 8.8 0 0 8.8 86.31 349.69 Tm (7 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0281 Tc 8.8 0 0 8.8 154.7388 349.206 Tm (19.00 )Tj EMC /Suspect <>BDC 0 Tc 8.697 0 Td (0)Tj 0.329 g -0.035 Tc 8.5664 0 0 8.8 236.46 349.21 Tm (.9)Tj 0.196 0.196 0.192 rg 0 Tc 8.8 0 0 8.8 242.79 349.21 Tm (0 )Tj EMC /Suspect <>BDC 0.255 0.259 0.255 rg 0.048 Tc 7.908 0.055 Td (3.0 )Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf 0.05 Tc 8.8142 0 0 8.8 397.88 349.69 Tm (47 )Tj -0.0052 Tc 8.8 0 0 8.8 484.98 349.69 Tm (158 )Tj 0 Tc -45.256 -1.201 Td (8 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0399 Tc 8.8 0 0 8.8 158.8344 339.614 Tm (4.40 )Tj EMC /Suspect <>BDC 0.255 0.259 0.255 rg 0.0239 Tc 8.231 0 Td (0.26 )Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf 0.016 Tc 8.8 0 0 8.8 398.2736 339.614 Tm (58 )Tj 0 Tc -35.452 -1.2 Td (9 )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0144 Tc 8.8 0 0 8.8 154.7336 329.538 Tm (12.20 )Tj EMC /Suspect <>BDC 0.0239 Tc 8.697 0 Td (0.12 )Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 402.6208 329.538 Tm (9 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.829 0 0 8.8 82.25 319.44 Tm (10 )Tj EMC /Suspect <>BDC 0.043 Tc 8.8 0 0 8.8 158.77 319.44 Tm (6.10 )Tj EMC /Suspect <>BDC 0 Tc 8.239 0 Td (0)Tj 0.329 g 0.535 0 Td (.)Tj 0.196 0.196 0.192 rg 0.05 Tc 8.8968 0 0 8.8 237.98 319.44 Tm (94 )Tj EMC ET BT /T1_0 1 Tf 0.0221 Tc 8.8 0 0 8.8 393.78 319.93 Tm (154 )Tj -0.035 Tc 8.5945 0 0 9.1 82.26 309.37 Tm (11 )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0223 Tc 8.8 0 0 8.8 159.06 309.37 Tm (1.20 )Tj EMC /Suspect <>BDC 0.196 0.196 0.192 rg -0.0307 Tc 8.206 0.053 Td (0.11 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.8968 0 0 8.8 397.82 309.84 Tm (92 )Tj 0.255 0.259 0.255 rg 9.3195 0 0 8.8 81.76 299.28 Tm (12 )Tj ET BT /Suspect <>BDC 0.196 0.196 0.192 rg /T1_0 1 Tf 0.0144 Tc 8.8 0 0 8.8 154.74 299.28 Tm (17.80 )Tj EMC /Suspect <>BDC 0.0057 Tc 8.697 0 Td (0.25 )Tj EMC ET BT /T1_0 1 Tf -0.0013 Tc 8.8 0 0 8.8 398.5792 299.764 Tm (14 )Tj -0.035 Tc 8.5945 0 0 9.1 82.26 289.69 Tm (13 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.023 Tc 8.8 0 0 8.8 158.83 289.69 Tm (2.90 )Tj EMC /Suspect <>BDC 0.0239 Tc 8.177 0 Td (0.28 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.8968 0 0 8.8 397.82 290.16 Tm (97 )Tj 8.829 0 0 8.8 81.77 279.61 Tm (14 )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0249 Tc 8.8 0 0 8.8 158.77 279.61 Tm (6.20 )Tj EMC /Suspect <>BDC 0.196 0.196 0.192 rg 0.042 Tc 8.184 0 Td (0.90 )Tj EMC ET BT /T1_0 1 Tf 0.0221 Tc 8.8 0 0 8.8 393.7828 280.094 Tm (145 )Tj -0.0013 Tc -35.455 -1.2 Td (15 )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0249 Tc 8.8 0 0 8.8 158.77 269.534 Tm (6.00 )Tj EMC /Suspect <>BDC 0.196 0.196 0.192 rg 0.0057 Tc 8.184 0 Td (0.47 )Tj EMC /Suspect <>BDC 0.255 0.259 0.255 rg -0.0142 Tc 9.273 0 Td (0.5 )Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf 0.05 Tc 8.8942 0 0 8.8 397.83 270 Tm (78 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.365 0 0 8.8 488.53 270 Tm (90 )Tj EMC ET BT /T1_0 1 Tf 8.829 0 0 8.8 81.77 259.44 Tm (16 )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0286 Tc 8.8 0 0 8.8 154.03 259.93 Tm (24.40 )Tj EMC /Suspect <>BDC 0.196 0.196 0.192 rg 0 Tc 8.723 0 Td (0)Tj 0.329 g 0.0017 Tc 0.535 0 Td (.8)Tj 0.196 0.196 0.192 rg 0 Tc 0.774 0 Td (0 )Tj EMC /Suspect <>BDC -0.0142 Tc 7.964 0 Td (0.8 )Tj EMC ET BT 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0187 Tc 8.8 0 0 8.8 397.8252 259.93 Tm (33 )Tj 0.196 0.196 0.192 rg 0.05 Tc 9.0021 0 0 8.8 488.54 260.41 Tm (33 )Tj -0.0013 Tc 8.8 0 0 8.8 81.78 249.85 Tm (17 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0057 Tc 8.8 0 0 8.8 158.7888 249.85 Tm (0.06 )Tj EMC /Suspect <>BDC 0 Tc 8.182 0 Td (0)Tj 0.329 g 0.59 0 Td (.)Tj 0.196 0.196 0.192 rg -0.035 Tc 8.6496 0 0 8.8 237.51 249.85 Tm (01 )Tj EMC ET BT /T1_0 1 Tf -0.0042 Tc 8.8 0 0 8.8 393.07 250.33 Tm (241 )Tj 0.255 0.259 0.255 rg -0.0013 Tc -35.374 -1.201 Td (18 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0249 Tc 8.8 0 0 8.8 158.3124 239.7612 Tm (7.20 )Tj EMC /Suspect <>BDC 0.0223 Tc 8.267 0 Td (1.90 )Tj EMC ET BT /T1_0 1 Tf 0.0231 Tc 8.8 0 0 8.8 393.07 240.254 Tm (263 )Tj 0.196 0.196 0.192 rg -0.0013 Tc -35.374 -1.2 Td (19 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 158.3124 229.694 Tm (0)Tj 0.329 g 0.59 0 Td (.)Tj 0.196 0.196 0.192 rg 0.05 Tc 8.8942 0 0 8.8 165.03 229.69 Tm (75 )Tj EMC /Suspect <>BDC 0.0057 Tc 8.8 0 0 8.8 230.79 230.65 Tm (0,07 )Tj EMC ET BT 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0067 Tc 8.8 0 0 8.8 397.8228 230.1572 Tm (93 )Tj ET BT /Suspect <>BDC 0.196 0.196 0.192 rg /T1_0 1 Tf 0.05 Tc 8.845 0 0 8.8 81.07 219.61 Tm (20 )Tj EMC /Suspect <>BDC 0.0057 Tc 8.8 0 0 8.8 158.31 219.61 Tm (0.28 )Tj EMC /Suspect <>BDC 0 Tc 8.182 0.055 Td (0)Tj 0.329 g 0.59 0 Td (.)Tj 0.196 0.196 0.192 rg 0.05 Tc 8.8682 0 0 8.8 237.03 220.09 Tm (05 )Tj EMC ET BT /T1_0 1 Tf -0.0052 Tc 8.8 0 0 8.8 393.78 220.57 Tm (178 )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0141 Tc 8.8 0 0 8.8 71.9288 200.4092 Tm (geometric )Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf 0.0259 Tc 8.8 0 0 8.8 111.8192 200.4092 Tm (mean )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0399 Tc 8.8 0 0 8.8 157.8784 200.4092 Tm (4.10 )Tj EMC /Suspect <>BDC 0.255 0.259 0.255 rg 0.042 Tc 8.231 0 Td (0.30 )Tj EMC /Suspect <>BDC 0.0057 Tc 9.273 0 Td (0.09 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.8942 0 0 8.8 397.35 200.89 Tm (73 )Tj 0.0493 Tc 8.8 0 0 8.8 484.02 200.89 Tm (112 )Tj 0.0128 Tc -46.822 -2.401 Td (normal )Tj 0.196 0.196 0.192 rg 0 Tc 1.549 -1.091 Td (1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0008 Tc 8.8 0 0 8.8 149.9368 170.1604 Tm (172.0 )Tj EMC /Suspect <>BDC 0.0131 Tc 9.133 0 Td (0.8 )Tj EMC /Suspect <>BDC 0.255 0.259 0.255 rg 0.0198 Tc 9.266 0.056 Td (8.0 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 401.7224 171.1372 Tm (4)Tj 0.11 0.11 0.106 rg 0.584 0 Td (.)Tj 0.255 0.259 0.255 rg 0.18 0 Td (4 )Tj 0.196 0.196 0.192 rg 0.05 Tc 8.8142 0 0 8.8 488.12 171.13 Tm (46 )Tj 0 Tc 8.8 0 0 8.8 85.39 160.09 Tm (2 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0195 Tc 8.8 0 0 8.8 149.1812 160.574 Tm (370.0 )Tj EMC ET BT /T1_0 1 Tf -0.0174 Tc 8.8 0 0 8.8 229.8772 160.574 Tm (4.1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0187 Tc 8.8 0 0 8.8 307.0972 160.574 Tm (39)Tj 0.329 g 0 Tc 1.082 0 Td (.)Tj 0.196 0.196 0.192 rg 0.174 0 Td (0 )Tj EMC /Suspect <>BDC 0.255 0.259 0.255 rg 0.0041 Tc 9.085 0 Td (11.0 )Tj EMC /Suspect <>BDC 0.196 0.196 0.192 rg -0.0325 Tc 9.818 0.055 Td (105 )Tj EMC ET BT 0.255 0.259 0.255 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 84.8532 150.014 Tm (3 )Tj ET BT /Suspect <>BDC 0.196 0.196 0.192 rg /T1_0 1 Tf 0.05 Tc 8.8968 0 0 8.8 153.5 150.01 Tm (90)Tj 0.329 g 0.0017 Tc 8.8 0 0 8.8 163.02 150.01 Tm (.0 )Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf -0.035 Tc 8.6596 0 0 8.8 230.58 150.01 Tm (1.1 )Tj 0.255 0.259 0.255 rg 0.048 Tc 8.8 0 0 8.8 311.42 150.49 Tm (3.2 )Tj 0.0223 Tc 9.795 0.055 Td (12.2 )Tj 0.05 Tc 9.0021 0 0 8.8 488.06 150.97 Tm (36 )Tj 0.196 0.196 0.192 rg 0 Tc 8.8 0 0 8.8 84.92 140.41 Tm (4 )Tj 0.0099 Tc 7.791 0 Td (56.6 )Tj 0.255 0.259 0.255 rg 0.0207 Tc 8.675 0.055 Td (3.3 )Tj 0.196 0.196 0.192 rg 0.0099 Tc 9.28 0 Td (4.4 )Tj 0.0281 Tc 9.755 0.055 Td (59.2 )Tj 0.0064 Tc 10.367 0 Td (78 )Tj /T1_2 1 Tf 0 Tc 9.3 0 0 9.3 84.87 130.33 Tm (5 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0471 Tc 8.8 0 0 8.8 153.02 130.8 Tm (39.0 )Tj EMC ET BT /T1_0 1 Tf 0.0107 Tc 8.8 0 0 8.8 230.5832 130.8 Tm (1.4 )Tj 0.0099 Tc 9.193 0 Td (4.2 )Tj -0.0074 Tc 9.757 0.056 Td (35.1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0221 Tc 8.8 0 0 8.8 484.0232 131.7592 Tm (107 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 84.8552 120.2488 Tm (6 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0417 Tc 8.8 0 0 8.8 148.5056 120.2488 Tm (115.0 )Tj EMC ET BT 0.255 0.259 0.255 rg /T1_0 1 Tf -0.0127 Tc 8.8 0 0 8.8 230.2928 120.7152 Tm (6.2 )Tj 0.0207 Tc 9.219 0 Td (3.2 )Tj 0.196 0.196 0.192 rg 0.016 Tc 9.761 0.055 Td (53)Tj 0.329 g 0.0017 Tc 1.084 0 Td (.9 )Tj 0.196 0.196 0.192 rg 0.05 Tc 8.845 0 0 8.8 488.11 121.2 Tm (28 )Tj ET BT /Suspect <>BDC 0.255 0.259 0.255 rg /T1_0 1 Tf 0.0141 Tc 8.8 0 0 8.8 71.45 100.57 Tm (geometric )Tj EMC ET BT 0.196 0.196 0.192 rg /T1_0 1 Tf 0.0441 Tc 8.8 0 0 8.8 110.8564 100.57 Tm (mean )Tj -0.0052 Tc 4.332 0 Td (105)Tj 0.329 g 0 Tc 1.541 0 Td (.)Tj 0.196 0.196 0.192 rg 0.227 0 Td (9 )Tj -0.0155 Tc 7.424 0 Td (2.1 )Tj 0.0146 Tc 9.266 0.053 Td (6.2 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0411 Tc 8.8 0 0 8.8 396.9092 101.5204 Tm (20.0 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.9782 0 0 8.8 488.04 101.52 Tm (58 )Tj ET endstream endobj 3 0 obj <>stream Hd͊zy8 >sRhF^#y QG#Oç==o/ϧ;c_mӷKv|~_oo~y>}~W=|z>{O݇q~?>Ï?o+~ߒ~;%zΏx߽w;>lp?(O?{wٸ^ PZUuTGu^5P5FjFDMԤU 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18.2400055 568.8000031 555.3600006 cm /Im6 Do Q q 16.3200073 0 0 33.6000061 568.8000031 467.0399933 cm /Im7 Do Q q 15.3600006 0 0 144.9600067 568.8000031 317.2799988 cm /Im8 Do Q q 11.5200043 0 0 41.2799988 570.7200012 275.0399933 cm /Im9 Do Q q 12.4799957 0 0 14.3999939 568.8000031 182.8800049 cm /Im10 Do Q q 12.4799957 0 0 18.2400055 568.8000031 148.3200073 cm /Im11 Do Q q 12.4799957 0 0 18.2400055 568.8000031 117.6000061 cm /Im12 Do Q q 18.2400055 0 0 37.4400024 563.0399933 75.3600006 cm /Im13 Do Q q 67.1999969 0 0 53.7599945 514.0800018 16.8000031 cm /Im14 Do Q q 24 0 0 12.4799957 421.9199982 19.6799927 cm /Im15 Do Q q 16.3200073 0 0 12.4799957 460.3200073 19.6799927 cm /Im16 Do Q BT /Suspect <>BDC 0.2 0.204 0.196 rg /T1_0 1 Tf 0.0236 Tc 3 Tr 7.1 0 0 7.1 222.71 770.17 Tm (AIRWAYS )Tj EMC /Suspect <>BDC 0.0174 Tc 5.135 0 Td (RESPONSrYENESS )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 7.3817 0 0 7.1 323.46 770.17 Tm (TO )Tj 0.294 0.294 0.29 rg 0.0376 Tc 7.1 0 0 7.1 335.96 770.17 Tm (LTE)Tj 0 Tc 1.894 -0.541 Td (4 )Tj 0.2 0.204 0.196 rg -0.0012 Tc 8.8 0 0 8.8 513.98 771.12 Tm (915 )Tj 0.05 Tc 10.1194 0 0 9.7 48.38 745.21 Tm (at )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.593 0 0 9.7 59.42 745.21 Tm (a>flow )Tj EMC ET BT /T1_0 1 Tf 0.0293 Tc 9.7 0 0 9.7 88.31 745.21 Tm (rate )Tj 0.05 Tc 10.5727 0 0 9.7 106.46 745.21 Tm (of )Tj 0.114 0.114 0.11 rg 0 Tc 9.7 0 0 9.7 119.18 745.21 Tm (1 )Tj ET BT /Suspect <>BDC 0.2 0.204 0.196 rg /T1_0 1 Tf 0.0132 Tc 9.7 0 0 9.7 126.6975 745.21 Tm (ml\267min)Tj 0.384 0.384 0.38 rg 0 Tc 2.901 0 Td (\267)Tj /T1_1 1 Tf 6.2 0 0 6.2 157.72 748.56 Tm (1 )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf 0.0033 Tc 9.7 0 0 9.7 164.63 745.21 Tm (with )Tj /T1_2 1 Tf -0.035 Tc 10.4134 0 0 10.5 185.09 745.21 Tm (65% )Tj /T1_0 1 Tf 0.0069 Tc 9.7 0 0 9.7 207.34 745.21 Tm (methanol )Tj 0.0122 Tc 4.147 0 Td (\(BDH\), )Tj 0.0191 Tc -20.536 -1.138 Td (34.9% )Tj 0.012 Tc 3.326 0 Td (water, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0386 Tc 9.7 0 0 9.7 110.7765 734.1714 Tm (0.1% )Tj EMC ET BT /T1_0 1 Tf 0.0121 Tc 9.7 0 0 9.7 138.1402 734.1714 Tm (acetic )Tj 0.007 Tc 3.019 0 Td (acid, )Tj 0.114 0.114 0.11 rg 0.05 Tc 9.8813 0 0 9.7 192.5 734.17 Tm (pH )Tj 0.2 0.204 0.196 rg 0.0062 Tc 9.7 0 0 9.7 211.07 734.17 Tm (5.6, )Tj 0.0203 Tc 2.131 0 Td (as )Tj 0.008 Tc 1.48 0 Td (solvent. )Tj 0.0201 Tc -20.375 -1.139 Td (Absorbance )Tj 0.017 Tc 5.593 0 Td (was )Tj 0.013 Tc 2.226 0 Td (monitored )Tj 0.0198 Tc 4.851 0 Td (with )Tj 0.0083 Tc 2.465 0 Td (an )Tj 0.0183 Tc 1.585 0 Td (on-line )Tj 0.0105 Tc 3.558 0 Td (spectro\255)Tj 0.0178 Tc -20.323 -1.089 Td (photometer )Tj 0.0084 Tc 4.939 0 Td (linked )Tj 0.0171 Tc 2.827 0 Td (to )Tj 0.05 Tc 9.7766 0 0 9.7 132.86 712.56 Tm (an )Tj 0.114 0.114 0.11 rg 0.0047 Tc 9.7 0 0 9.7 145.36 712.56 Tm (integrator )Tj 0.2 0.204 0.196 rg 0.0049 Tc 4.203 0 Td (\(Spectraphysics, )Tj -0.0046 Tc 6.937 0 Td (model )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.2178 0 0 9.7 47.81 701.53 Tm (SP )Tj EMC /Suspect <>BDC 0.0391 Tc 9.7 0 0 9.7 64.28 701.53 Tm (4270\))Tj 0.039 0.039 0.035 rg 0 Tc 2.507 0 Td (. )Tj EMC ET BT 0.114 0.114 0.11 rg /T1_0 1 Tf 0.0235 Tc 9.7 0 0 9.7 95.9214 701.53 Tm (The )Tj 0.2 0.204 0.196 rg 0.0192 Tc 2.137 0 Td (purity )Tj 0.05 Tc 10.5727 0 0 9.7 146.3 701.53 Tm (of )Tj 0.114 0.114 0.11 rg 9.7615 0 0 9.7 159.79 701.53 Tm (LTE)Tj 0 Tc 6.4001 0 0 6.4001 178.06 697.68 Tm (4 )Tj 0.2 0.204 0.196 rg 0.0062 Tc 9.7 0 0 9.7 187.69 701.53 Tm (before )Tj 0.0253 Tc 3.107 0 Td (challenge )Tj -0.0078 Tc 4.561 0 Td (was )Tj 0.0212 Tc -22.078 -1.139 Td (confirmed )Tj -0.0007 Tc 4.711 0 Td (by )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0067 Tc 9.7 0 0 9.7 107.9172 690.4817 Tm (its )Tj EMC ET BT /T1_0 1 Tf 0.0193 Tc 9.7 0 0 9.7 120.857 690.4817 Tm (elution )Tj 0.0203 Tc 3.315 0 Td (as )Tj 0 Tc 1.287 0 Td (a )Tj 0.0227 Tc 0.887 0 Td (single )Tj 0.0341 Tc 2.886 0 Td (peak )Tj 0.0333 Tc 2.364 0 Td (at )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0067 Tc 9.7 0 0 9.7 236.5683 690.4817 Tm (its )Tj EMC ET BT /T1_0 1 Tf 0.0103 Tc 9.7 0 0 9.7 250.0901 690.4817 Tm (unique )Tj 0.0202 Tc -20.884 -1.089 Td (retention )Tj 0.0198 Tc 4.156 0 Td (time )Tj 0.05 Tc 11.1292 0 0 9.7 108.85 679.92 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0083 Tc 9.7 0 0 9.7 121.38 679.92 Tm (25\2610.4 )Tj EMC ET BT /T1_0 1 Tf 0.017 Tc 9.7 0 0 9.7 153.099 679.92 Tm (min )Tj -0.0348 Tc 1.97 0 Td (\(mean\261sEM, )Tj 0.029 Tc 5.256 0 Td (n= )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.6677 0 0 9.7 234.87 679.92 Tm (10\) )Tj EMC ET BT 0.114 0.114 0.11 rg /T1_0 1 Tf 0.0309 Tc 9.7 0 0 9.7 250.96 679.92 Tm (in )Tj 0.2 0.204 0.196 rg 0.0146 Tc 1.194 0 Td (this )Tj 0.384 0.384 0.38 rg 0.027 Tc -22.132 -1.137 Td (so)Tj 0.2 0.204 0.196 rg 0.03 Tc 0.946 0 Td (lv)Tj 0.384 0.384 0.38 rg 0 Tc 0.74 0 Td (e)Tj 0.2 0.204 0.196 rg -0.0314 Tc 0.554 0 Td (nt )Tj 0.384 0.384 0.38 rg 0.0264 Tc 1.125 0 Td (syste)Tj 0.2 0.204 0.196 rg 0 Tc 2.091 0 Td (m)Tj 0.384 0.384 0.38 rg 0.823 0 Td (. )Tj 0.2 0.204 0.196 rg 0.0235 Tc 0.606 0 Td (The )Tj 0.0147 Tc 1.978 0 Td (concentration )Tj 0.05 Tc 10.5727 0 0 9.7 191.9 668.89 Tm (of )Tj 0.0097 Tc 9.7 0 0 9.7 204.46 668.89 Tm (the )Tj 0.294 0.294 0.29 rg 0.0234 Tc 1.621 0 Td (stock )Tj 0.2 0.204 0.196 rg 0.0102 Tc 2.524 0 Td (solution )Tj 0.294 0.294 0.29 rg 0.017 Tc -20.275 -1.138 Td (was )Tj 0.0129 Tc 2.02 0 Td (assessed )Tj -0.035 Tc 9.5458 0 0 9.7 106.09 657.85 Tm (by )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0038 Tc 9.7 0 0 9.7 119.51 657.85 Tm (UV )Tj EMC ET BT /T1_0 1 Tf 0.0193 Tc 9.7 0 0 9.7 138.0952 657.85 Tm (scanning )Tj 0.2 0.204 0.196 rg 0.0333 Tc 4.062 0 Td (at )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0265 Tc 9.7 0 0 9.7 188.574 657.85 Tm (280 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.03 0 0 9.7 207.83 657.85 Tm (nM )Tj 0.0208 Tc 9.7 0 0 9.7 225.5 657.85 Tm (assuming )Tj 0.0083 Tc 4.305 0 Td (an )Tj ET BT /Suspect <>BDC 0.384 0.384 0.38 rg /T1_0 1 Tf 0.0207 Tc 9.7 0 0 9.7 47.4177 647.2867 Tm (extinc)Tj 0.2 0.204 0.196 rg 0.0106 Tc 2.581 0 Td (tion )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf 0.0176 Tc 9.7 0 0 9.7 90.1462 647.2867 Tm (coefficie)Tj 0.2 0.204 0.196 rg 0.0181 Tc 3.67 0 Td (nt )Tj 0.05 Tc 11.1292 0 0 9.7 135.25 647.29 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0271 Tc 9.7 0 0 9.7 146.36 647.29 Tm (40,000 )Tj EMC /Suspect <>BDC 0.0173 Tc 3.112 0 Td (cm\267)Tj 0 Tc 6.5001 0 0 6.5001 191.3 650.17 Tm (1)Tj 0.0417 Tc 9.7 0 0 9.7 194.68 647.29 Tm (\267M)Tj 0.384 0.384 0.38 rg 0 Tc 1.138 0 Td (\267)Tj 0.2 0.204 0.196 rg 6.5001 0 0 6.5001 208.58 650.65 Tm (1 )Tj EMC ET BT /T1_0 1 Tf 0.0263 Tc 9.7 0 0 9.7 213.98 647.29 Tm (and )Tj 0.0155 Tc 1.733 0 Td (dilutions )Tj 0.05 Tc 10.0163 0 0 9.7 268.7 647.29 Tm (of )Tj 0.0313 Tc 9.7 0 0 9.7 47.95 636.24 Tm (LTE)Tj 0 Tc 5.5001 0 0 5.5001 65.74 633.36 Tm (4 )Tj 0.294 0.294 0.29 rg 0.0143 Tc 9.7 0 0 9.7 74.87 636.24 Tm (were )Tj 0.2 0.204 0.196 rg 0.0159 Tc 2.476 0 Td (prepar)Tj 0.384 0.384 0.38 rg 0 Tc 2.611 0 Td (e)Tj 0.2 0.204 0.196 rg 0.446 0 Td (d )Tj 0.294 0.294 0.29 rg -0.0186 Tc 1.535 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0219 Tc 9.7 0 0 9.7 160.2688 636.24 Tm (PBS. )Tj EMC /Suspect <>BDC -0.0121 Tc 3.111 0 Td (On )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf -0.011 Tc 9.7 0 0 9.7 212.0377 636.24 Tm (fo)Tj 0.2 0.204 0.196 rg 0.0088 Tc 0.902 0 Td (ur )Tj ET BT /Suspect <>BDC 0.384 0.384 0.38 rg /T1_0 1 Tf 0.0119 Tc 9.7 0 0 9.7 237.9755 636.24 Tm (occasions )Tj EMC ET BT /T1_0 1 Tf 0.0477 Tc 9.7 0 0 9.7 47.3608 625.6767 Tm (samp)Tj 0.2 0.204 0.196 rg -0.0273 Tc 2.282 0 Td (les )Tj 0.294 0.294 0.29 rg 0.05 Tc 10.5727 0 0 9.7 85.82 625.68 Tm (of )Tj 0.2 0.204 0.196 rg -0.035 Tc 9.0854 0 0 9.7 100.3 625.68 Tm (th)Tj 0.384 0.384 0.38 rg 0 Tc 9.7 0 0 9.7 107.42 625.68 Tm (e )Tj 0.027 Tc 0.738 0 Td (so)Tj 0.2 0.204 0.196 rg 0.002 Tc 0.946 0 Td (lution )Tj 0.0134 Tc 2.679 0 Td (remaining )Tj 0.294 0.294 0.29 rg -0.0186 Tc 4.496 0 Td (in )Tj -0.035 Tc 8.8064 0 0 9.7 203.98 625.68 Tm (t.he )Tj 0.2 0.204 0.196 rg 0 Tc 9.7 0 0 9.7 218.87 625.68 Tm (n)Tj 0.384 0.384 0.38 rg 0.0059 Tc 0.486 0 Td (ebu)Tj 0.2 0.204 0.196 rg -0.035 Tc 8.5757 0 0 9.7 238.49 625.68 Tm (li)Tj 0.384 0.384 0.38 rg 0.0144 Tc 9.7 0 0 9.7 243.79 625.68 Tm (zer )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf 0.0156 Tc 9.7 0 0 9.7 258.6176 625.68 Tm (after )Tj EMC /Suspect <>BDC 0.0097 Tc -21.716 -1.089 Td (the )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf 0.0193 Tc 9.7 0 0 9.7 62.3903 615.1167 Tm (high)Tj 0.384 0.384 0.38 rg 0.0492 Tc 1.822 0 Td (est )Tj 0.294 0.294 0.29 rg 0.0105 Tc 1.436 0 Td (concentration )Tj 0.05 Tc 11.0338 0 0 9.7 150.61 615.12 Tm (ofL )Tj 0.0336 Tc 9.7 0 0 9.7 167.44 615.12 Tm (TE)Tj 0 Tc 6.2 0 0 6.2 179.5 611.76 Tm (4 )Tj 0.017 Tc 9.7 0 0 9.7 186.23 615.12 Tm (was )Tj 0.384 0.384 0.38 rg -0.0132 Tc 1.822 0 Td (adm)Tj 0.2 0.204 0.196 rg -0.0241 Tc 1.784 0 Td (ini)Tj 0.384 0.384 0.38 rg 0.013 Tc 1.033 0 Td (stered )Tj 0.294 0.294 0.29 rg -0.0045 Tc 2.785 0 Td (wer)Tj 0.459 0.459 0.455 rg 0 Tc 1.475 0 Td (e )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf 0.0183 Tc 9.7 0 0 9.7 47.4327 604.0911 Tm (analysed )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.5458 0 0 9.7 86.41 604.09 Tm (by )Tj 0.2 0.204 0.196 rg 0.0331 Tc 9.7 0 0 9.7 98.84 604.09 Tm (RP-HPLC )Tj 0.294 0.294 0.29 rg 0.0263 Tc 4.596 0 Td (and )Tj 0.2 0.204 0.196 rg -0.0007 Tc 1.842 0 Td (by )Tj 0.0367 Tc 1.382 0 Td (mea)Tj 0.384 0.384 0.38 rg 0.05 Tc 9.9809 0 0 9.7 190.9 604.09 Tm (su)Tj 0.2 0.204 0.196 rg 0 Tc 9.7 0 0 9.7 200.15 604.09 Tm (r)Tj 0.384 0.384 0.38 rg 0.0259 Tc 0.337 0 Td (ement )Tj 0.294 0.294 0.29 rg 0.05 Tc 10.5727 0 0 9.7 230.78 604.09 Tm (of )Tj ET BT /Suspect <>BDC 0.2 0.204 0.196 rg /T1_0 1 Tf 0.0027 Tc 9.7 0 0 9.7 242.4 604.09 Tm (ultravi)Tj 0.384 0.384 0.38 rg 0.0286 Tc 2.663 0 Td (o\255)Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf 0.004 Tc 9.7 0 0 9.7 47.9247 593.0514 Tm (let )Tj 0.05 Tc 9.7766 0 0 9.7 61.34 593.05 Tm (ab)Tj 0.384 0.384 0.38 rg 9.9809 0 0 9.7 70.9 593.05 Tm (so)Tj 0.2 0.204 0.196 rg 0.0219 Tc 9.7 0 0 9.7 80.15 593.05 Tm (rbance )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf 0.05 Tc 10.7518 0 0 9.7 110.77 593.05 Tm (at )Tj EMC /Suspect <>BDC 9.7148 0 0 9.7 121.86 593.05 Tm (280 )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf -0.035 Tc 9.6876 0 0 9.7 141.59 593.05 Tm (nm )Tj -0.0324 Tc 9.7 0 0 9.7 158.38 593.05 Tm (to )Tj 0 Tc 1.18 0 Td (d)Tj 0.384 0.384 0.38 rg 0.0222 Tc 0.543 0 Td (ete)Tj 0.2 0.204 0.196 rg -0.035 Tc 9.3801 0 0 9.7 186.7 593.05 Tm (m1in)Tj 0.384 0.384 0.38 rg 0 Tc 9.7 0 0 9.7 205.34 593.05 Tm (e )Tj 0.294 0.294 0.29 rg 0.0494 Tc 0.942 0 Td (if )Tj 0.2 0.204 0.196 rg -0.035 Tc 9.0854 0 0 9.7 224.62 593.05 Tm (th)Tj 0.384 0.384 0.38 rg 0 Tc 9.7 0 0 9.7 231.74 593.05 Tm (e )Tj 0.2 0.204 0.196 rg 0.0192 Tc 0.902 0 Td (purity )Tj 0.384 0.384 0.38 rg 0.0286 Tc 2.86 0 Td (or )Tj 0.0209 Tc -22.812 -1.09 Td (concentratio)Tj 0.2 0.204 0.196 rg 0 Tc 5.204 0 Td (n )Tj 0.294 0.294 0.29 rg 0.05 Tc 11.1292 0 0 9.7 105.01 582.48 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0313 Tc 9.7 0 0 9.7 117.07 582.48 Tm (LTE )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf -0.0268 Tc 9.7 0 0 9.7 145.9081 582.48 Tm (had )Tj 0.384 0.384 0.38 rg 0 Tc 2.12 0 Td (c)Tj 0.2 0.204 0.196 rg -0.002 Tc 0.503 0 Td (han)Tj 0.384 0.384 0.38 rg 0.0034 Tc 1.477 0 Td (ged )Tj 0.294 0.294 0.29 rg 0.0241 Tc 2.127 0 Td (during )Tj ET BT /Suspect <>BDC 0.2 0.204 0.196 rg /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 239.5131 582.48 Tm (n)Tj 0.384 0.384 0.38 rg 0.01 Tc 0.486 0 Td (ebuliza\255)Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf 0.0073 Tc 9.7 0 0 9.7 47.5113 571.4414 Tm (tion. )Tj 0.05 Tc 9.7615 0 0 9.7 73.87 571.44 Tm (LTE)Tj 0 Tc 5.5001 0 0 5.5001 92.14 568.56 Tm (4 )Tj 0.028 Tc 9.7 0 0 9.7 104.06 571.44 Tm (after )Tj 0.0103 Tc 2.335 0 Td (nebulization )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 179.9043 571.44 Tm (e)Tj 0.114 0.114 0.11 rg 0.497 0 Td (l)Tj 0.294 0.294 0.29 rg 0.0042 Tc 0.305 0 Td (uted )Tj EMC ET BT /T1_0 1 Tf 0.0203 Tc 9.7 0 0 9.7 208.7036 571.44 Tm (as )Tj 0 Tc 1.287 0 Td (a )Tj 0.384 0.384 0.38 rg 0.0469 Tc 0.837 0 Td (sing)Tj 0.2 0.204 0.196 rg 0 Tc 1.788 0 Td (l)Tj 0.384 0.384 0.38 rg 0.245 0 Td (e )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf 0.0176 Tc 9.7 0 0 9.7 257.7759 571.44 Tm (peak )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf -0.0299 Tc 9.7 0 0 9.7 47.5187 560.4111 Tm (wh)Tj 0.384 0.384 0.38 rg 0 Tc 1.228 0 Td (e)Tj 0.2 0.204 0.196 rg 0.504 0 Td (n )Tj 0.384 0.384 0.38 rg 0.828 0 Td (s)Tj 0.2 0.204 0.196 rg 0.0046 Tc 0.46 0 Td (ubjected )Tj 0.114 0.114 0.11 rg 0 Tc 3.858 0 Td (t)Tj 0.294 0.294 0.29 rg 0.24 0 Td (o )Tj 0.0248 Tc 0.896 0 Td (RP-HPLC )Tj 0.0016 Tc 4.645 0 Td (and )Tj 0.2 0.204 0.196 rg 0.0345 Tc 1.889 0 Td (the )Tj ET BT /Suspect <>BDC 0.384 0.384 0.38 rg /T1_0 1 Tf 0.05 Tc 9.867 0 0 9.7 203.9 560.41 Tm (co)Tj 0.2 0.204 0.196 rg 0.0005 Tc 9.7 0 0 9.7 213.59 560.41 Tm (nc)Tj 0.384 0.384 0.38 rg 0 Tc 0.931 0 Td (e)Tj 0.2 0.204 0.196 rg -0.0051 Tc 0.554 0 Td (ntrati)Tj 0.384 0.384 0.38 rg 0 Tc 2.12 0 Td (o)Tj 0.2 0.204 0.196 rg 0.553 0 Td (n )Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg 0.0168 Tc 0.833 0 Td (dif\255)Tj EMC ET BT /T1_0 1 Tf 0.0018 Tc 9.7 0 0 9.7 47.4193 549.8467 Tm (fered )Tj -0.0007 Tc 2.536 0 Td (by )Tj 0.2 0.204 0.196 rg 0 Tc 1.426 0 Td (l)Tj 0.384 0.384 0.38 rg 0.0179 Tc 0.245 0 Td (ess )Tj 0.2 0.204 0.196 rg 0.0048 Tc 1.641 0 Td (than )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf 0.0099 Tc 9.7 0 0 9.7 125.4267 549.8467 Tm (10% )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf -0.0273 Tc 9.7 0 0 9.7 147.7367 549.8467 Tm (from )Tj 0.007 Tc 2.338 0 Td (pre-n)Tj 0.384 0.384 0.38 rg 0.017 Tc 2.166 0 Td (eb)Tj 0.2 0.204 0.196 rg 0.0025 Tc 1.049 0 Td (ulization )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf -0.0042 Tc 9.7 0 0 9.7 239.9837 549.8467 Tm (values. )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.7836 0 0 9.7 55.64 538.8 Tm (For )Tj 0 Tc 9.7 0 0 9.7 75.31 538.8 Tm (L )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.9558 0 0 9.7 81.03 538.8 Tm (TE)Tj 0 Tc 6.1 0 0 6.1 93.58 535.92 Tm (4 )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf 9.7 0 0 9.7 102.15 538.8 Tm (c)Tj 0.2 0.204 0.196 rg -0.0193 Tc 0.503 0 Td (hall)Tj 0.384 0.384 0.38 rg 0.0235 Tc 1.475 0 Td (enges, )Tj 0.294 0.294 0.29 rg 0.0072 Tc 3.167 0 Td (each )Tj 0.384 0.384 0.38 rg 0 Tc 2.421 0 Td (s)Tj 0.2 0.204 0.196 rg -0.0196 Tc 0.41 0 Td (ubj)Tj 0.384 0.384 0.38 rg 0.0245 Tc 1.326 0 Td (ec)Tj 0.2 0.204 0.196 rg 0 Tc 0.948 0 Td (t )Tj 0.294 0.294 0.29 rg 0.0075 Tc 0.786 0 Td (inhaled )Tj 0.384 0.384 0.38 rg 0.0178 Tc 3.513 0 Td (geomet\255)Tj 0.2 0.204 0.196 rg 0.0122 Tc -20.232 -1.138 Td (rically )Tj 0.0103 Tc 3.16 0 Td (increa)Tj 0.384 0.384 0.38 rg 0.0025 Tc 2.468 0 Td (si)Tj 0.2 0.204 0.196 rg -0.007 Tc 0.706 0 Td (ng )Tj 0.294 0.294 0.29 rg 0.0179 Tc 1.476 0 Td (concentrations )Tj 0.05 Tc 10.5727 0 0 9.7 186.14 527.76 Tm (of )Tj 0.0066 Tc 9.7 0 0 9.7 199.63 527.76 Tm (LTE)Tj 0 Tc 6.2 0 0 6.2 216.94 524.41 Tm (4 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0139 Tc 9.7 0 0 9.7 225.46 527.76 Tm (starting )Tj EMC ET BT /T1_0 1 Tf 0.0333 Tc 9.7 0 0 9.7 260.0599 527.76 Tm (at )Tj 0.2 0.204 0.196 rg 0 Tc 1.237 0 Td (a )Tj 0.294 0.294 0.29 rg 0.0188 Tc -23.257 -1.088 Td (concentration )Tj 0.05 Tc 10.5727 0 0 9.7 106.94 517.21 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0177 Tc 9.7 0 0 9.7 121.34 517.21 Tm (0.18 )Tj EMC /Suspect <>BDC 0.2 0.204 0.196 rg -0.035 Tc 7.8663 0 0 9.7 144.67 517.21 Tm (j.l)Tj 0.384 0.384 0.38 rg 0.007 Tc 9.7 0 0 9.7 150.16 517.21 Tm (g\267)Tj 0.2 0.204 0.196 rg -0.035 Tc 9.4624 0 0 9.7 157.9 517.21 Tm (ml)Tj 0.384 0.384 0.38 rg 0 Tc 9.7 0 0 9.7 168.28 517.21 Tm (\267)Tj 6.5001 0 0 6.5001 171.14 520.56 Tm (1 )Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg -0.01 Tc 9.7 0 0 9.7 179.89 517.21 Tm (\(0.4 )Tj EMC /Suspect <>BDC 0.2 0.204 0.196 rg /T1_1 1 Tf -0.0114 Tc 9.4 0 0 9.4 201.25 517.21 Tm (j.tM\) )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf -0.035 Tc 9.2582 0 0 9.7 225.04 517.21 Tm (in )Tj 0.018 Tc 9.7 0 0 9.7 237.98 517.21 Tm (asthmatic )Tj 0.2 0.204 0.196 rg 0.0175 Tc -19.699 -1.139 Td (subjects )Tj 0.05 Tc 9.7132 0 0 9.7 82.94 506.16 Tm (and )Tj 9.7101 0 0 9.7 100.76 506.16 Tm (4.6 )Tj ET BT /Suspect <>BDC 0.114 0.114 0.11 rg /T1_0 1 Tf -0.035 Tc 8.4988 0 0 9.7 117.07 506.16 Tm (J.Lg\267ml\267)Tj 0.294 0.294 0.29 rg /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 143.32 509.53 Tm (1 )Tj EMC /Suspect <>BDC 0.2 0.204 0.196 rg /T1_0 1 Tf 0.0357 Tc 9.7 0 0 9.7 150.13 506.16 Tm (\(10 )Tj EMC /Suspect <>BDC -0.035 Tc 6.9981 0 0 9.7 167.48 506.16 Tm (J.L.M\) )Tj EMC ET BT /T1_0 1 Tf 0.0309 Tc 9.7 0 0 9.7 189.04 506.16 Tm (in )Tj -0.0012 Tc 1.195 0 Td (normal )Tj 0.384 0.384 0.38 rg 0 Tc 3.253 0 Td (s)Tj 0.2 0.204 0.196 rg 0.0042 Tc 0.46 0 Td (ubje)Tj 0.384 0.384 0.38 rg 0 Tc 1.723 0 Td (c)Tj 0.2 0.204 0.196 rg 0.0291 Tc 0.453 0 Td (ts )Tj 0.294 0.294 0.29 rg -0.0292 Tc 1.08 0 Td (as )Tj 0.2 0.204 0.196 rg 0.0241 Tc -22.861 -1.138 Td (determined )Tj -0.0108 Tc 5.045 0 Td (from )Tj 0.0186 Tc 2.289 0 Td (previous )Tj 0.0201 Tc 3.844 0 Td (studies )Tj 0.0123 Tc 3.207 0 Td ([11]. )Tj 0.294 0.294 0.29 rg 0.025 Tc 2.286 0 Td (sGaw )Tj -0.0078 Tc 2.686 0 Td (was )Tj 0.2 0.204 0.196 rg 0 Tc 1.929 0 Td (m)Tj 0.384 0.384 0.38 rg 0.0149 Tc 0.734 0 Td (eas\255)Tj 0.2 0.204 0.196 rg 0.0185 Tc -21.961 -1.089 Td (ured )Tj 0.0193 Tc 2.217 0 Td (every )Tj /T1_2 1 Tf 0 Tc 10.5 0 0 10.5 94.45 484.56 Tm (5 )Tj /T1_0 1 Tf -0.0078 Tc 9.7 0 0 9.7 103.66 484.56 Tm (min )Tj 0.0012 Tc 1.97 0 Td (for )Tj 0.114 0.114 0.11 rg 0.0116 Tc 1.609 0 Td (15 )Tj 0.2 0.204 0.196 rg 0.0079 Tc 1.369 0 Td (minutes. )Tj /T1_1 1 Tf 0.05 Tc 13.1112 0 0 9.9 189.24 484.56 Tm (If )Tj /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 200.06 484.56 Tm (a )Tj 0.384 0.384 0.38 rg 0.0422 Tc 0.84 0 Td (35% )Tj 0.294 0.294 0.29 rg 0.0193 Tc 2.278 0 Td (decrease )Tj 0.2 0.204 0.196 rg -0.035 Tc 9.2582 0 0 9.7 268.72 484.56 Tm (in )Tj 0.294 0.294 0.29 rg 0.0415 Tc 9.7 0 0 9.7 46.42 473.53 Tm (sGaw )Tj 0.2 0.204 0.196 rg 0.017 Tc 2.686 0 Td (was )Tj 0.114 0.114 0.11 rg 0.0312 Tc 1.88 0 Td (not )Tj 0.2 0.204 0.196 rg 0.0177 Tc 1.574 0 Td (achieved )Tj 0.0148 Tc 3.968 0 Td (within )Tj 0.0116 Tc 2.935 0 Td (15 )Tj 0.114 0.114 0.11 rg 0.0201 Tc 1.27 0 Td (minute)Tj 0.294 0.294 0.29 rg 0 Tc 2.858 0 Td (s )Tj 0.2 0.204 0.196 rg 0.0345 Tc 0.656 0 Td (the )Tj 0.0122 Tc 1.527 0 Td (concentra\255)Tj -0.0059 Tc -19.292 -1.089 Td (tion )Tj 0.05 Tc 10.5727 0 0 9.7 66.62 462.97 Tm (of )Tj 0 Tc 9.7 0 0 9.7 78.67 462.97 Tm (L )Tj 0.05 Tc 9.9558 0 0 9.7 85.35 462.97 Tm (TE)Tj 0 Tc 6.2 0 0 6.2 97.9 459.61 Tm (4 )Tj -0.0186 Tc 9.7 0 0 9.7 105.52 462.97 Tm (in )Tj -0.0324 Tc 1.293 0 Td (th)Tj 0.384 0.384 0.38 rg 0 Tc 0.734 0 Td (e )Tj 0.2 0.204 0.196 rg 0.006 Tc 0.949 0 Td (nebuli)Tj 0.384 0.384 0.38 rg 0.0144 Tc 2.569 0 Td (zer )Tj 0.294 0.294 0.29 rg -0.0078 Tc 1.736 0 Td (was )Tj 0.0069 Tc 2.022 0 Td (increased )Tj 0.0488 Tc 4.314 0 Td (by )Tj 0.384 0.384 0.38 rg 0.0183 Tc 1.423 0 Td (3-fol)Tj 0.2 0.204 0.196 rg 0 Tc 2.031 0 Td (d )Tj 0.0263 Tc -23.16 -1.138 Td (and )Tj 0.0345 Tc 1.938 0 Td (the )Tj 0.0133 Tc 1.686 0 Td (protocol )Tj 0 Tc 3.907 0 Td (r)Tj 0.384 0.384 0.38 rg 0.0122 Tc 0.288 0 Td (epeated. )Tj 0.294 0.294 0.29 rg 0.0482 Tc 3.812 0 Td (The )Tj 0.0122 Tc 2.085 0 Td (timings )Tj 0.05 Tc 10.5727 0 0 9.7 213.02 451.93 Tm (of )Tj 0.384 0.384 0.38 rg 0.015 Tc 9.7 0 0 9.7 225.51 451.93 Tm (observations )Tj 0.2 0.204 0.196 rg 0.0308 Tc -18.449 -1.138 Td (were )Tj 0.0398 Tc 2.328 0 Td (based )Tj -0.035 Tc 9.6549 0 0 9.7 94.95 440.89 Tm (on )Tj 0.114 0.114 0.11 rg 0.0171 Tc 9.7 0 0 9.7 107.5 440.89 Tm (th)Tj 0.294 0.294 0.29 rg 0 Tc 0.833 0 Td (e )Tj 0.2 0.204 0.196 rg 0.0161 Tc 0.752 0 Td (re)Tj 0.384 0.384 0.38 rg 0 Tc 0.778 0 Td (s)Tj 0.2 0.204 0.196 rg 0.0176 Tc 0.46 0 Td (ult)Tj 0.384 0.384 0.38 rg 0 Tc 1.025 0 Td (s )Tj 0.294 0.294 0.29 rg 0.05 Tc 10.0163 0 0 9.7 152.06 440.89 Tm (of )Tj 0.0256 Tc 9.7 0 0 9.7 162.73 440.89 Tm (previous )Tj 0.384 0.384 0.38 rg 0 Tc 3.894 0 Td (s)Tj 0.2 0.204 0.196 rg 0.0086 Tc 0.408 0 Td (tudie)Tj 0.384 0.384 0.38 rg 0 Tc 2.017 0 Td [(s )-94([)]TJ 0.2 0.204 0.196 rg -0.035 Tc 9.6677 0 0 9.7 234.87 440.89 Tm (11])Tj 0.459 0.459 0.455 rg 0 Tc 9.7 0 0 9.7 247.96 440.89 Tm (. )Tj 0.2 0.204 0.196 rg 0.0007 Tc 0.561 0 Td (Bron)Tj 0.384 0.384 0.38 rg 0 Tc 2.022 0 Td (\255)Tj 0.2 0.204 0.196 rg 0.0175 Tc -23.355 -1.139 Td (choconstriction )Tj 0.0193 Tc 6.68 0 Td (commences )Tj 0.0333 Tc 5.195 0 Td (at )Tj /T1_2 1 Tf 0 Tc 10.7 0 0 10.7 172.21 429.84 Tm (5 )Tj /T1_0 1 Tf 0.0262 Tc 9.7 0 0 9.7 179.98 429.84 Tm (minutes )Tj 0.0156 Tc 3.604 0 Td (after )Tj 0.0144 Tc 2.179 0 Td (inhalation )Tj 0.05 Tc 10.5727 0 0 9.7 46.46 419.28 Tm (of )Tj 0 Tc 9.7 0 0 9.7 58.03 419.28 Tm (L )Tj 0.05 Tc 9.9558 0 0 9.7 64.23 419.28 Tm (TE)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 76.3 415.93 Tm (4 )Tj /T1_0 1 Tf 0.0033 Tc 9.7 0 0 9.7 83.99 419.28 Tm (with )Tj ET BT /Suspect <>BDC 0.114 0.114 0.11 rg /T1_0 1 Tf 0.0122 Tc 9.7 0 0 9.7 105.0972 419.28 Tm (maximal )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf 0.0129 Tc 9.7 0 0 9.7 143.5286 419.28 Tm (bronchoconstriction )Tj 0.0188 Tc 8.6 0 Td (occurring )Tj 0.05 Tc 10.1194 0 0 9.7 268.7 419.28 Tm (at )Tj 0.0243 Tc 9.7 0 0 9.7 46.09 408.72 Tm (between )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0142 Tc 9.7 0 0 9.7 84.1431 408.72 Tm (10--15 )Tj EMC ET BT /T1_0 1 Tf 0.0097 Tc 9.7 0 0 9.7 112.7872 408.72 Tm (minutes )Tj 0.028 Tc 3.604 0 Td (after )Tj 0.0077 Tc 2.328 0 Td (inhalation. )Tj 0.0202 Tc -11.872 -1.137 Td (Measurements )Tj 0.05 Tc 11.1292 0 0 9.7 116.05 397.69 Tm (of )Tj 0.294 0.294 0.29 rg 0.025 Tc 9.7 0 0 9.7 127.54 397.69 Tm (sGaw )Tj 0.2 0.204 0.196 rg 0.0308 Tc 2.636 0 Td (were )Tj 0.114 0.114 0.11 rg 0.0392 Tc 2.275 0 Td (made )Tj 0.2 0.204 0.196 rg -0.0186 Tc 2.518 0 Td (in )Tj 0 Tc 1.087 0 Td (a )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0024 Tc 9.7 0 0 9.7 217.4299 397.69 Tm (total )Tj EMC ET BT /T1_0 1 Tf 0.0128 Tc 9.7 0 0 9.7 238.1006 397.69 Tm (body )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0297 Tc 9.7 0 0 9.7 259.7025 397.69 Tm (ple\255)Tj EMC ET BT /T1_0 1 Tf 0.0177 Tc 9.7 0 0 9.7 46.5547 386.6514 Tm (thysmograph )Tj 0.0084 Tc 5.784 0 Td (linked )Tj -0.0324 Tc 2.975 0 Td (to )Tj 0 Tc 1.179 0 Td (a )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0134 Tc 9.7 0 0 9.7 151.1207 386.6514 Tm (digital )Tj EMC ET BT /T1_0 1 Tf 0.0294 Tc 9.7 0 0 9.7 179.92 386.6514 Tm (computer )Tj 0.0203 Tc 4.304 0 Td (as )Tj 0.0161 Tc 1.248 0 Td (previously )Tj 0.0237 Tc -19.359 -1.089 Td (described )Tj 0.294 0.294 0.29 rg -0.0124 Tc 4.39 0 Td ([15]. )Tj ET BT /Suspect <>BDC 0.2 0.204 0.196 rg /T1_0 1 Tf 0.0358 Tc 9.7 0 0 9.7 110.3613 376.0881 Tm (Four )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.8951 0 0 9.7 132.46 376.09 Tm (to )Tj 0.294 0.294 0.29 rg 0 Tc 9.7 0 0 9.7 143.38 376.09 Tm (s)Tj 0.114 0.114 0.11 rg 0.452 0 Td (i)Tj 0.294 0.294 0.29 rg 0.253 0 Td (x )Tj 0.2 0.204 0.196 rg 0.0118 Tc 0.892 0 Td (measurements )Tj 0.05 Tc 11.1292 0 0 9.7 218.77 376.09 Tm (of )Tj 0.294 0.294 0.29 rg 0.0415 Tc 9.7 0 0 9.7 230.26 376.09 Tm (sGaw )Tj 0.2 0.204 0.196 rg 0.0143 Tc (were )Tj 0.0239 Tc -18.989 -1.138 Td (recorded )Tj 0.05 Tc 10.1194 0 0 9.7 86.3 365.05 Tm (at )Tj 0.0237 Tc 9.7 0 0 9.7 98.3 365.05 Tm (each )Tj 0.114 0.114 0.11 rg 0.0033 Tc 2.482 0 Td (time )Tj 0.2 0.204 0.196 rg 0.0331 Tc 2.279 0 Td (point )Tj 0.0263 Tc 2.661 0 Td (and )Tj -0.015 Tc 2.087 0 Td (the )Tj 0.0063 Tc 1.732 0 Td (mean )Tj 0.0173 Tc 2.722 0 Td (value )Tj 0.114 0.114 0.11 rg 0.0417 Tc 2.723 0 Td (was )Tj 0.2 0.204 0.196 rg 0.0079 Tc -22.078 -1.139 Td (calculated. )Tj 0.0209 Tc 4.657 0 Td (Baseline )Tj 0.294 0.294 0.29 rg 0.025 Tc 3.8 0 Td (sGaw )Tj 0.2 0.204 0.196 rg -0.0078 Tc 2.636 0 Td (was )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0099 Tc 9.7 0 0 9.7 170.8366 354.0017 Tm (>0.9 )Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg -0.0199 Tc 2.119 0 Td (s\267)Tj 0 Tc 6.4001 0 0 6.4001 198.02 357.37 Tm (1)Tj -0.0066 Tc 9.7 0 0 9.7 201.4 354 Tm (\267kPa\267)Tj 0 Tc 6.4001 0 0 6.4001 221.06 357.84 Tm (1 )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf 0.0237 Tc 9.7 0 0 9.7 226.57 354 Tm (prior )Tj 0.0171 Tc 2.224 0 Td (to )Tj 0.0237 Tc 1.031 0 Td (each )Tj 0.294 0.294 0.29 rg 0.0346 Tc -21.871 -1.089 Td (cha)Tj 0.114 0.114 0.11 rg -0.035 Tc 9.5285 0 0 9.7 60.4 343.44 Tm (ll)Tj 0.294 0.294 0.29 rg 0 Tc 9.7 0 0 9.7 65.66 343.44 Tm (e)Tj 0.114 0.114 0.11 rg 0.0425 Tc 0.455 0 Td (ng)Tj 0.294 0.294 0.29 rg 0 Tc 1.03 0 Td (e )Tj 0.2 0.204 0.196 rg -0.0186 Tc 1.041 0 Td (in )Tj 0.018 Tc 1.334 0 Td (asthmatic )Tj 0.294 0.294 0.29 rg 0.015 Tc 4.499 0 Td (subjects. )Tj 0.2 0.204 0.196 rg 0.0204 Tc 4.167 0 Td (Mean )Tj 0.0217 Tc 2.875 0 Td (baseline )Tj 0.0085 Tc 3.943 0 Td (sGaw )Tj 0.0208 Tc -21.365 -1.137 Td (measurements )Tj 0.034 Tc 6.426 0 Td (did )Tj 0.05 Tc 9.7838 0 0 9.7 126.23 332.41 Tm (not )Tj 0.0331 Tc 9.7 0 0 9.7 143.91 332.41 Tm (differ )Tj 0.294 0.294 0.29 rg 0.016 Tc 2.815 0 Td (significan)Tj 0.114 0.114 0.11 rg -0.0062 Tc 4.12 0 Td (tly )Tj 0.2 0.204 0.196 rg -0.035 Tc 9.2582 0 0 9.7 226.96 332.41 Tm (in )Tj 0.0097 Tc 9.7 0 0 9.7 239.5 332.41 Tm (the )Tj 0.0245 Tc 1.724 0 Td (asth\255)Tj 0.114 0.114 0.11 rg 0.0159 Tc -21.666 -1.138 Td (matic )Tj 0.2 0.204 0.196 rg 0.0175 Tc 2.66 0 Td (subjects )Tj 0.05 Tc 9.7902 0 0 9.7 107.43 321.37 Tm (on )Tj 0.0097 Tc 9.7 0 0 9.7 121.42 321.37 Tm (the )Tj 0.114 0.114 0.11 rg 0.04 Tc 1.584 0 Td (thr)Tj 0.294 0.294 0.29 rg 0.05 Tc 9.9537 0 0 9.7 147.73 321.37 Tm (ee )Tj 0.0215 Tc 9.7 0 0 9.7 160.18 321.37 Tm (study )Tj 0.2 0.204 0.196 rg 0.0261 Tc 2.578 0 Td (days, )Tj 0.0041 Tc 2.584 0 Td (being )Tj ET BT /Suspect <>BDC 0.114 0.114 0.11 rg /T1_0 1 Tf 0.007 Tc 9.7 0 0 9.7 235.8206 321.37 Tm (1.49\2610.)Tj 0.294 0.294 0.29 rg 0.0113 Tc 3.093 0 Td (09 )Tj EMC /Suspect <>BDC -0.0199 Tc -22.668 -1.138 Td (s\267)Tj 0 Tc 6.2 0 0 6.2 52.59 314.16 Tm (1)Tj 0.015 Tc 9.7 0 0 9.7 55.96 310.33 Tm (\267kPa\267l, )Tj EMC /Suspect <>BDC 0.2 0.204 0.196 rg 0.004 Tc 2.905 0 Td (1.52\2610.09 )Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg -0.0199 Tc 4.276 0 Td (s\267)Tj 0 Tc 6.2 0 0 6.2 132.27 313.69 Tm (1)Tj 0.039 0.039 0.035 rg 9.7 0 0 9.7 135.64 310.33 Tm (\267)Tj 0.2 0.204 0.196 rg 0.0427 Tc 0.216 0 Td (kPa)Tj 0.384 0.384 0.38 rg 0 Tc 1.515 0 Td (\267)Tj 0.2 0.204 0.196 rg 6.2 0 0 6.2 155.79 313.69 Tm (1)Tj 0.484 -0.542 Td (, )Tj EMC ET BT /T1_0 1 Tf 0.0263 Tc 9.7 0 0 9.7 163.1 310.33 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.004 Tc 9.7 0 0 9.7 180.6182 310.33 Tm (1.44\2610.09 )Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg 0 Tc 4.276 0 Td (s)Tj 0.114 0.114 0.11 rg 0.39 0 Td (\267)Tj 0.294 0.294 0.29 rg 6.2 0 0 6.2 228.75 313.69 Tm (1)Tj 0.114 0.114 0.11 rg 0.0085 Tc 9.7 0 0 9.7 232.12 310.33 Tm (\267kPa)Tj 0.294 0.294 0.29 rg 0 Tc 1.692 0 Td (-)Tj 6.2 0 0 6.2 251.31 313.69 Tm (1 )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf 0.0237 Tc 9.7 0 0 9.7 256.81 310.33 Tm (prior )Tj 0.0171 Tc -21.727 -1.139 Td (to )Tj 0.114 0.114 0.11 rg 0 Tc 1.089 0 Td (m)Tj 0.294 0.294 0.29 rg 0.0151 Tc 0.783 0 Td (ethacholi)Tj 0.114 0.114 0.11 rg 0 Tc 3.82 0 Td (n)Tj 0.294 0.294 0.29 rg 0.0195 Tc 0.486 0 Td (e, )Tj 0.114 0.114 0.11 rg 0 Tc 0.945 0 Td (L )Tj 0.2 0.204 0.196 rg 0.0336 Tc 0.69 0 Td (TE)Tj /T1_1 1 Tf 0 Tc 5.5001 0 0 5.5001 133.42 295.93 Tm (4 )Tj /T1_0 1 Tf 0.0263 Tc 9.7 0 0 9.7 140.54 299.28 Tm (and )Tj 0.0161 Tc 1.791 0 Td (histamine )Tj 0.294 0.294 0.29 rg 0.0132 Tc 4.247 0 Td (chal)Tj 0.114 0.114 0.11 rg 0 Tc 1.782 0 Td (l)Tj 0.294 0.294 0.29 rg 0.0136 Tc 0.245 0 Td (enges, )Tj 0.2 0.204 0.196 rg 0.0225 Tc 2.83 0 Td (respec\255)Tj 0.0086 Tc -20.636 -1.089 Td (tively. )Tj /T1_2 1 Tf -0.0062 Tc 10.5 0 0 10.5 45.28 261.84 Tm (Analysis )Tj 0.294 0.294 0.29 rg 0.05 Tc 11.8974 0 0 10.5 83.42 261.84 Tm (of )Tj 0.2 0.204 0.196 rg -0.034 Tc 10.5 0 0 10.5 94.99 261.84 Tm (data )Tj /T1_0 1 Tf 0.0482 Tc 9.7 0 0 9.7 54.16 239.76 Tm (The )Tj 0.0206 Tc 2.176 0 Td (cumulative )Tj 0.0191 Tc 5.196 0 Td (dose )Tj 0.05 Tc 10.5727 0 0 9.7 149.18 239.76 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0161 Tc 9.7 0 0 9.7 163.67 239.76 Tm (histamine )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf 0.05 Tc 10.0163 0 0 9.7 207.74 239.76 Tm (or )Tj 0.114 0.114 0.11 rg 0 Tc 9.7 0 0 9.7 221.74 239.76 Tm (m)Tj 0.294 0.294 0.29 rg 0.0104 Tc 0.783 0 Td (ethac)Tj 0.114 0.114 0.11 rg 0.0071 Tc 2.187 0 Td (holin)Tj 0.294 0.294 0.29 rg 0 Tc 2.119 0 Td (e )Tj 0.2 0.204 0.196 rg 0.0264 Tc -23.298 -1.137 Td (required )Tj 0.0171 Tc 4.057 0 Td (to )Tj 0.0258 Tc 1.339 0 Td (produce )Tj 0 Tc 3.848 0 Td (a )Tj 0.294 0.294 0.29 rg 0.0174 Tc 1.038 0 Td (35% )Tj 0.2 0.204 0.196 rg -0.0209 Tc 2.474 0 Td (fall )Tj -0.0186 Tc 1.884 0 Td (in )Tj 0.294 0.294 0.29 rg 0.025 Tc 1.33 0 Td (sGaw )Tj ET BT /Suspect <>BDC 0.2 0.204 0.196 rg /T1_0 1 Tf 0.0458 Tc 9.7 0 0 9.7 228.3748 228.7311 Tm (\(PD,)Tj 0 Tc 6.9001 0 0 6.9001 248.07 225.37 Tm (5)Tj 0.425 0.487 Td (\) )Tj EMC ET BT /T1_0 1 Tf -0.0078 Tc 9.7 0 0 9.7 260.15 228.73 Tm (was )Tj 0.0241 Tc -22.177 -1.09 Td (determined )Tj 0.0488 Tc 5.652 0 Td (by )Tj 0.0235 Tc 2.02 0 Td (linear )Tj 0.0131 Tc 3.315 0 Td (interpolation )Tj -0.0108 Tc 6.281 0 Td (from )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0345 Tc 9.7 0 0 9.7 240.944 218.157 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0124 Tc 9.7 0 0 9.7 262.4877 218.157 Tm (log )Tj 0.0196 Tc -22.418 -1.137 Td (dose-response )Tj 0.015 Tc 6.136 0 Td (curve. )Tj 0.05 Tc 9.8955 0 0 9.7 131.95 207.13 Tm (Log )Tj 0.0123 Tc 9.7 0 0 9.7 151.66 207.13 Tm (transformed )Tj 0.026 Tc 5.238 0 Td (data )Tj -0.0078 Tc 2.037 0 Td (was )Tj 0.0183 Tc 1.871 0 Td (analysed )Tj 0.0488 Tc -20.129 -1.138 Td (by )Tj 0.0464 Tc 1.316 0 Td (Student's )Tj 0.0169 Tc 4.272 0 Td (t-test )Tj 0.0263 Tc 2.367 0 Td (and )Tj 0.014 Tc 1.832 0 Td (correlations )Tj 0.0308 Tc 5.204 0 Td (were )Tj 0.027 Tc 2.267 0 Td (assessed )Tj -0.0007 Tc 3.871 0 Td (by )Tj 0.114 0.114 0.11 rg 0.0171 Tc 1.333 0 Td (th)Tj 0.294 0.294 0.29 rg 0 Tc 0.783 0 Td (e )Tj 0.2 0.204 0.196 rg 0.0235 Tc -23.256 -1.138 Td (linear )Tj 0.0166 Tc 2.729 0 Td (regression )Tj 0.0132 Tc 4.642 0 Td (analysis. )Tj 0.114 0.114 0.11 rg 0.0122 Tc 10.2 0 0 10.2 149.23 157.21 Tm (Results )Tj 0.294 0.294 0.29 rg /T1_2 1 Tf -0.0096 Tc 10.5 0 0 10.5 44.24 135.61 Tm (Relative )Tj -0.0175 Tc 3.5 0 Td (potencies )Tj 0.384 0.384 0.38 rg 0.05 Tc 11.8974 0 0 10.5 122.3 135.61 Tm (of )Tj 0.294 0.294 0.29 rg 0.017 Tc 10.5 0 0 10.5 134.03 135.61 Tm (LT\243)Tj 0 Tc 6.6 0 0 6.6 151.14 131.76 Tm (4 )Tj -0.0233 Tc 10.5 0 0 10.5 159.79 135.61 Tm (metha)Tj 0.459 0.459 0.455 rg 0 Tc 2.374 0 Td (c)Tj 0.294 0.294 0.29 rg -0.0298 Tc 0.413 0 Td (holine )Tj ET BT /Suspect <>BDC 0.384 0.384 0.38 rg /T1_2 1 Tf -0.0142 Tc 10.5 0 0 10.5 217.3615 135.61 Tm (and )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_2 1 Tf -0.0256 Tc 10.5 0 0 10.5 236.0935 135.61 Tm (histamin)Tj 0.459 0.459 0.455 rg 0 Tc 3.289 0 Td (e )Tj 0.294 0.294 0.29 rg -0.016 Tc -21.53 -1.098 Td (asthmatic )Tj 0.384 0.384 0.38 rg 0 Tc 4.124 0 Td (s)Tj 0.2 0.204 0.196 rg -0.0143 Tc 0.4 0 Td (ubj)Tj 0.384 0.384 0.38 rg 0.0052 Tc 1.189 0 Td (ects)Tj 0.2 0.204 0.196 rg 0 Tc 1.553 0 Td (. )Tj 0.294 0.294 0.29 rg /T1_0 1 Tf 0.0482 Tc 9.7 0 0 9.7 127.12 124.08 Tm (The )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 11.5097 0 0 9.7 147.3 124.08 Tm (LtE)Tj /T1_1 1 Tf 0 Tc 7.8001 0 0 7.8001 164.87 119.28 Tm (1 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.0239 Tc 9.7 0 0 9.7 173.24 124.08 Tm (PD)Tj 0.459 0.459 0.455 rg 0.05 Tc 7.107 0 0 6.8001 185.68 120.72 Tm (35 )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf 0.025 Tc 9.7 0 0 9.7 197.14 124.08 Tm (sGaw )Tj 0.294 0.294 0.29 rg -0.0186 Tc 2.827 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.018 Tc 9.7 0 0 9.7 236.0661 124.08 Tm (asthmatic )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf 0.0192 Tc 9.7 0 0 9.7 44.5105 113.5167 Tm (subjec)Tj 0.2 0.204 0.196 rg 0 Tc 2.685 0 Td (t)Tj 0.384 0.384 0.38 rg 0.235 0 Td (s )Tj 0.294 0.294 0.29 rg 0.0105 Tc 0.904 0 Td (ranged )Tj 0.0057 Tc 3.206 0 Td (from )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0308 Tc 9.7 0 0 9.7 137.194 113.5167 Tm (0.06-24.4 )Tj EMC ET BT /T1_0 1 Tf -0.0073 Tc 9.7 0 0 9.7 181.9207 113.5167 Tm (nmol )Tj 0.384 0.384 0.38 rg -0.0026 Tc 2.563 0 Td (\(geom )Tj 0.294 0.294 0.29 rg 0.0063 Tc 3.077 0 Td (mean )Tj -0.0235 Tc 2.621 0 Td (4.1 )Tj 0.2 0.204 0.196 rg 0.0186 Tc -22.413 -1.138 Td (nmol, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0205 Tc 9.7 0 0 9.7 71.525 102.4781 Tm (n=)Tj 0.384 0.384 0.38 rg 0.0395 Tc 1.034 0 Td (20\), )Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg -0.035 Tc 7.4809 0 0 9.7 101.52 102.48 Tm (!11e )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf 9.458 0 0 9.7 117.58 102.48 Tm (metl1a)Tj 0.384 0.384 0.38 rg 0 Tc 9.7 0 0 9.7 141.51 102.48 Tm (c)Tj 0.2 0.204 0.196 rg 0.503 0 Td (h)Tj 0.384 0.384 0.38 rg 0.05 Tc 10.7117 0 0 9.7 151.1 102.48 Tm (ol)Tj 0.2 0.204 0.196 rg -0.035 Tc 9.2582 0 0 9.7 159.76 102.48 Tm (in)Tj 0.384 0.384 0.38 rg 0 Tc 9.7 0 0 9.7 166.94 102.48 Tm (e )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf 0.0239 Tc 9.7 0 0 9.7 175.1559 102.48 Tm (PD)Tj 0.459 0.459 0.455 rg 0.0251 Tc 6.8001 0 0 6.8001 187.6 98.64 Tm (35 )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf 0.025 Tc 9.7 0 0 9.7 198.1 102.48 Tm (sGaw )Tj 0.294 0.294 0.29 rg 0.0105 Tc 2.735 0 Td (ranged )Tj -0.0273 Tc 3.206 0 Td (from )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0177 Tc 9.7 0 0 9.7 44.0543 90.9564 Tm (0.01)Tj 0.459 0.459 0.455 rg 0 Tc 1.78 0 Td (-)Tj 0.294 0.294 0.29 rg -0.035 Tc 9.5256 0 0 9.7 68.31 90.96 Tm (1.9 )Tj EMC /Suspect <>BDC 8.8708 0 0 10 83.45 90.96 Tm (llffiOI )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf 0.0098 Tc 9.7 0 0 9.7 108.85 90.96 Tm (\(geom )Tj 0.294 0.294 0.29 rg 0.0063 Tc 3.077 0 Td (mean )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0342 Tc 9.7 0 0 9.7 164.0527 90.96 Tm (0.30 )Tj EMC /Suspect <>BDC -0.035 Tc 8.4661 0 0 9.7 185.71 90.96 Tm (J.Lmol, )Tj EMC /Suspect <>BDC 0.008 Tc 9.7 0 0 9.7 214.07 90.96 Tm (n=20\))Tj 0.459 0.459 0.455 rg 0 Tc 2.46 0 Td (, )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf 0.0263 Tc 9.7 0 0 9.7 243.7423 90.96 Tm (and )Tj 0.0097 Tc 1.988 0 Td (the )Tj ET BT /Suspect <>BDC 0.2 0.204 0.196 rg /T1_0 1 Tf -0.0308 Tc 9.7 0 0 9.7 299.0323 745.2056 Tm (hi)Tj 0.384 0.384 0.38 rg 0.0226 Tc 0.729 0 Td (stamine )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf 0.05 Tc 9.8732 0 0 9.7 340.76 745.21 Tm (PD )Tj 0.384 0.384 0.38 rg 0.025 Tc 9.7 0 0 9.7 364.18 745.21 Tm (sGaw )Tj 0.294 0.294 0.29 rg 0.0105 Tc 2.785 0 Td (ranged )Tj -0.0273 Tc 3.157 0 Td (from )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0139 Tc 9.7 0 0 9.7 444.3893 745.21 Tm (0.)Tj 0.459 0.459 0.455 rg 0.05 Tc 10.3145 0 0 9.7 452.04 745.21 Tm (3-3)Tj 0.294 0.294 0.29 rg 0.0349 Tc 9.7 0 0 9.7 467.32 745.21 Tm (.0 )Tj EMC /Suspect <>BDC -0.035 Tc 9.0771 0 0 10 478 745.21 Tm (llffiOI )Tj EMC /Suspect <>BDC 0.384 0.384 0.38 rg -0.0007 Tc 9.7 0 0 9.7 503.41 745.21 Tm (\(mean )Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg 0.0291 Tc -21.129 -1.089 Td (0.9 )Tj EMC /Suspect <>BDC -0.035 Tc 9.2535 0 0 10 314.8 734.65 Tm (llffiOI, )Tj EMC /Suspect <>BDC 0.2 0.204 0.196 rg -0.0128 Tc 9.7 0 0 9.7 342.71 734.65 Tm (n=9)Tj 0.384 0.384 0.38 rg 0 Tc 1.529 0 Td (\) )Tj EMC ET BT /T1_0 1 Tf 0.0165 Tc 9.7 0 0 9.7 364.6902 734.65 Tm (\(tab)Tj 0.2 0.204 0.196 rg 0.0375 Tc 1.636 0 Td (le )Tj 0 Tc 1.21 0 Td (1)Tj 0.384 0.384 0.38 rg 0.0297 Tc 0.375 0 Td (\). )Tj 0.294 0.294 0.29 rg 0.0482 Tc 0.988 0 Td (The )Tj 0.0108 Tc 2.036 0 Td (relative )Tj 0.0104 Tc 3.515 0 Td (potency )Tj 0.384 0.384 0.38 rg 0 Tc 3.602 0 Td (o)Tj 0.2 0.204 0.196 rg 0.542 0 Td (f )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf 0.0313 Tc 9.7 0 0 9.7 506.3393 734.65 Tm (LTE)Tj 0 Tc 5.5001 0 0 5.5001 524.14 731.29 Tm (4 )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf -0.0324 Tc 9.7 0 0 9.7 299.02 723.61 Tm (to )Tj 0.294 0.294 0.29 rg 0.0107 Tc 1.287 0 Td (methacholine )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0204 Tc 9.7 0 0 9.7 369.4905 723.61 Tm (\(PD)Tj 0.459 0.459 0.455 rg /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 385.37 719.76 Tm (3 )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf 0.0261 Tc 9.7 0 0 9.7 397.4 723.61 Tm (Meth/PD )Tj 0.384 0.384 0.38 rg 0 Tc 4.196 0 Td (s )Tj 0.294 0.294 0.29 rg 0.851 0 Td (L )Tj 0.0336 Tc 0.64 0 Td (TE)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 464.62 720.24 Tm (4)Tj 0.605 0.544 Td (\) )Tj /T1_0 1 Tf 0.0184 Tc 9.7 0 0 9.7 476.63 723.61 Tm (rang)Tj 0.459 0.459 0.455 rg 0 Tc 1.822 0 Td (e)Tj 0.294 0.294 0.29 rg 0.496 0 Td (d )Tj 0.0057 Tc 0.938 0 Td (from )Tj 0.05 Tc 9.7604 0 0 9.7 298.45 712.56 Tm (9-263 )Tj 0.384 0.384 0.38 rg 0.0081 Tc 9.7 0 0 9.7 327.73 712.56 Tm (\(gco)Tj 0.2 0.204 0.196 rg 0 Tc 1.84 0 Td (m )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf -0.0102 Tc 9.7 0 0 9.7 357.5769 712.56 Tm (mean )Tj EMC /Suspect <>BDC /C0_0 1 Tf 0 Tc 4.8 0 0 12.48 383.05 712.56 Tm <0037007E>Tj 0.459 0.459 0.455 rg 1.92 0 0 12.48 393.13 712.56 Tm <002E0020>Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf -0.004 Tc 9.7 0 0 9.7 399.83 712.56 Tm (n=20\). )Tj EMC /Suspect <>BDC 0.384 0.384 0.38 rg 0.05 Tc 9.9227 0 0 9.7 429.35 712.56 Tm (:the )Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg 0.0178 Tc 9.7 0 0 9.7 449.75 712.56 Tm (relative )Tj EMC ET BT /T1_0 1 Tf 0.0187 Tc 9.7 0 0 9.7 483.8455 712.56 Tm (potency )Tj 0.384 0.384 0.38 rg 0.05 Tc 10.5727 0 0 9.7 519.26 712.56 Tm (of )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf 10.0118 0 0 9.7 297.54 701.53 Tm (LTE)Tj 0 Tc 6.8001 0 0 6.8001 316.29 698.65 Tm (4 )Tj EMC /Suspect <>BDC 0.008 Tc 9.2 0 0 9.2 324.46 701.53 Tm (to )Tj EMC ET BT /T1_0 1 Tf 0.01 Tc 9.7 0 0 9.7 335.99 701.53 Tm (histamine )Tj ET BT /Suspect <>BDC /C0_0 1 Tf 0 Tc 5.28 0 0 7.68 378.24 701.53 Tm <002800500044>Tj 0.459 0.459 0.455 rg 3.6 0 0 7.68 394.08 701.53 Tm <007E007E0020>Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf -0.035 Tc 9.5713 0 0 9.7 405.56 701.53 Tm (Hi)Tj 0.459 0.459 0.455 rg 0 Tc 9.7 0 0 9.7 415.06 701.53 Tm (s)Tj 0.294 0.294 0.29 rg 0.005 Tc 0.452 0 Td (i/PD)Tj 0.459 0.459 0.455 rg 0.0251 Tc 6.8001 0 0 6.8001 437.2 698.17 Tm (35 )Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg 0.0313 Tc 9.7 0 0 9.7 448.75 701.53 Tm (LTE)Tj 0 Tc 6.8001 0 0 6.8001 466.53 698.17 Tm (4)Tj 0.563 0.494 Td (\) )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf 0.0055 Tc 9.7 0 0 9.7 477.59 701.53 Tm (ran)Tj 0.384 0.384 0.38 rg 0.0281 Tc 1.279 0 Td (ged )Tj 0.294 0.294 0.29 rg -0.0108 Tc 1.927 0 Td (from )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.742 0 0 9.7 298.04 690.97 Tm (45)Tj 0.459 0.459 0.455 rg 0 Tc 9.7 0 0 9.7 308.53 690.97 Tm (-)Tj 0.294 0.294 0.29 rg 0.0341 Tc 0.493 0 Td (550 )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf -0.0026 Tc 9.7 0 0 9.7 332.5278 690.97 Tm (\(geom )Tj 0.294 0.294 0.29 rg 0.0063 Tc 2.978 0 Td (mean )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0178 Tc 9.7 0 0 9.7 387.0127 690.97 Tm (112, )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 408.4594 690.97 Tm (n)Tj 0.459 0.459 0.455 rg 0.0005 Tc 0.491 0 Td (=9\))Tj 0.294 0.294 0.29 rg 0 Tc 1.469 0 Td (. )Tj /T1_2 1 Tf -0.033 Tc 10.5 0 0 10.5 298.17 668.89 Tm (Normal )Tj 0.459 0.459 0.455 rg 0 Tc 3.24 0 Td (s)Tj 0.294 0.294 0.29 rg -0.0329 Tc 0.446 0 Td (ubjects. )Tj /T1_0 1 Tf 0.0482 Tc 9.7 0 0 9.7 370.96 668.89 Tm (The )Tj 0.384 0.384 0.38 rg 0.05 Tc 9.7615 0 0 9.7 390.19 668.89 Tm (LTE)Tj 0 Tc 6.1 0 0 6.1 408.46 666 Tm (4 )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_2 1 Tf -0.035 Tc 9.765 0 0 10.5 415.76 668.89 Tm (PD})Tj 0 Tc 6.7 0 0 6.7 432.41 665.53 Tm (5 )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf 0.025 Tc 9.7 0 0 9.7 440.02 668.89 Tm (sGaw )Tj 0.294 0.294 0.29 rg -0.035 Tc 9.2582 0 0 9.7 466.96 668.89 Tm (in )Tj 0.0186 Tc 9.7 0 0 9.7 478.55 668.89 Tm (normal )Tj ET BT /Suspect <>BDC 0.384 0.384 0.38 rg /T1_0 1 Tf 0.0117 Tc 9.7 0 0 9.7 510.1041 668.89 Tm (sub\255)Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf 0.038 Tc 9.7 0 0 9.7 297.8293 658.3267 Tm (jects )Tj 0.2 0.204 0.196 rg 0.0055 Tc 2.202 0 Td (ran)Tj 0.384 0.384 0.38 rg 0.0281 Tc 1.279 0 Td (ged )Tj 0.294 0.294 0.29 rg -0.0273 Tc 1.828 0 Td (from )Tj ET BT /Suspect <>BDC 0.384 0.384 0.38 rg /T1_0 1 Tf 0.05 Tc 9.9275 0 0 9.7 370.92 658.33 Tm (39-370 )Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg 9.7015 0 0 9.7 403.67 658.33 Tm (nmoltgcom )Tj EMC ET BT /T1_0 1 Tf 0.0063 Tc 9.7 0 0 9.7 455.5 658.33 Tm (mean )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0003 Tc 9.7 0 0 9.7 480.138 658.33 Tm (105.9 )Tj EMC ET BT /T1_0 1 Tf 0.0063 Tc 9.7 0 0 9.7 504.9506 658.33 Tm (nmol, )Tj -0.0041 Tc -21.278 -1.138 Td (n=6\) )Tj 0.384 0.384 0.38 rg 0.0242 Tc 2.167 0 Td (\(table )Tj 0.294 0.294 0.29 rg 0 Tc 2.747 0 Td (1)Tj 0.459 0.459 0.455 rg 0.0297 Tc 0.375 0 Td (\), )Tj 0.294 0.294 0.29 rg 0.0097 Tc 0.944 0 Td (the )Tj 0.0152 Tc 1.534 0 Td (methacholine )Tj 0.05 Tc 9.8732 0 0 9.7 429.56 647.29 Tm (PD)Tj 0.459 0.459 0.455 rg 7.5807 0 0 7.2 442.47 643.44 Tm (35 )Tj 0 Tc 9.7 0 0 9.7 452.5 647.29 Tm (s)Tj 0.294 0.294 0.29 rg 0.029 Tc 0.449 0 Td (Gaw )Tj 0.2 0.204 0.196 rg 0 Tc 2.236 0 Td (r)Tj 0.384 0.384 0.38 rg 0.0124 Tc 0.337 0 Td (anged )Tj 0.294 0.294 0.29 rg -0.0273 Tc 2.77 0 Td (from )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0428 Tc 9.7 0 0 9.7 297.9693 636.2417 Tm (0.8-6.2 )Tj EMC /Suspect <>BDC -0.035 Tc 9.1334 0 0 9.7 331.63 636.24 Tm (Jl010l )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf 0.0098 Tc 9.7 0 0 9.7 356.53 636.24 Tm (\(geom )Tj 0.294 0.294 0.29 rg 0.0063 Tc 2.978 0 Td (mean )Tj 0.384 0.384 0.38 rg 0.0112 Tc 2.569 0 Td (2.)Tj 0.2 0.204 0.196 rg 0 Tc 0.911 0 Td (1 )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf -0.035 Tc 9.6826 0 0 9.7 426.95 636.24 Tm (j.lmol)Tj 0.459 0.459 0.455 rg 0 Tc 9.7 0 0 9.7 448.65 636.24 Tm (, )Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg -0.035 Tc 9.597 0 0 9.7 454.55 636.24 Tm (n:::6\), )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf 0.0016 Tc 9.7 0 0 9.7 479.42 636.24 Tm (and )Tj 0.2 0.204 0.196 rg -0.0324 Tc 1.839 0 Td (th)Tj 0.384 0.384 0.38 rg 0 Tc 0.783 0 Td (e )Tj 0.294 0.294 0.29 rg -0.02 Tc 0.851 0 Td (his\255)Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0094 Tc 9.7 0 0 9.7 298.5344 625.6767 Tm (tanline )Tj EMC /Suspect <>BDC 0.05 Tc 9.8732 0 0 9.7 328.76 625.68 Tm (PD)Tj 0.459 0.459 0.455 rg 7.5807 0 0 7.2 341.19 621.85 Tm (35 )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf 0.025 Tc 9.7 0 0 9.7 352.66 625.68 Tm (sGaw )Tj 0.2 0.204 0.196 rg -0.035 Tc 9.2582 0 0 9.7 379.6 625.68 Tm (in )Tj 0 Tc 9.7 0 0 9.7 391.19 625.68 Tm (r)Tj 0.384 0.384 0.38 rg 0.0248 Tc 0.288 0 Td (anged )Tj 0.294 0.294 0.29 rg -0.0108 Tc 2.919 0 Td (from )Tj 0.384 0.384 0.38 rg 0.05 Tc 9.7851 0 0 9.7 445.33 625.68 Tm (3.2-39 )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf -0.035 Tc 8.4388 0 0 10 477.07 625.68 Tm (JlffiOI )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf -0.0026 Tc 9.7 0 0 9.7 502.45 625.68 Tm (\(geom )Tj 0.294 0.294 0.29 rg -0.0102 Tc -21.022 -1.089 Td (mean )Tj 0.384 0.384 0.38 rg 0.05 Tc 9.7782 0 0 9.7 324.36 615.12 Tm (6.2 )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf -0.035 Tc 7.757 0 0 10 342.2 615.12 Tm (J.iffiOI)Tj 0.459 0.459 0.455 rg 0 Tc 10 0 0 10 363.68 615.12 Tm (, )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf 9.7 0 0 9.7 371.03 615.12 Tm (n)Tj 0.459 0.459 0.455 rg 0.0252 Tc 0.491 0 Td (=6\))Tj 0.294 0.294 0.29 rg 0 Tc 1.469 0 Td (. )Tj 0.0482 Tc 0.755 0 Td (The )Tj 0.0201 Tc 2.126 0 Td (airways )Tj 0.0114 Tc 3.77 0 Td (respon)Tj 0.459 0.459 0.455 rg 0 Tc 2.758 0 Td (s)Tj 0.294 0.294 0.29 rg 0.0074 Tc 0.452 0 Td (iveness )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0324 Tc 9.7 0 0 9.7 519.8377 615.12 Tm (to )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 298.0472 604.0911 Tm (L )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.9558 0 0 9.7 303.75 604.09 Tm (TE)Tj 0 Tc 5.5001 0 0 5.5001 316.3 601.21 Tm (4)Tj 0.459 0.459 0.455 rg 0.775 0.524 Td (, )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf 0.0197 Tc 9.7 0 0 9.7 328.78 604.09 Tm (methacholine )Tj 0.384 0.384 0.38 rg 0.0263 Tc 6.177 0 Td (and )Tj 0.294 0.294 0.29 rg 0.0187 Tc 2.187 0 Td (hi)Tj 0.459 0.459 0.455 rg 0 Tc 0.778 0 Td (s)Tj 0.294 0.294 0.29 rg 0.0311 Tc 0.408 0 Td (tamine )Tj -0.0078 Tc 3.514 0 Td (was )Tj 0.384 0.384 0.38 rg 0.0108 Tc 2.213 0 Td (significantly )Tj 0.294 0.294 0.29 rg 0.0188 Tc -18.452 -1.138 Td (greater )Tj 0.2 0.204 0.196 rg -0.035 Tc 9.2582 0 0 9.7 330.64 593.05 Tm (in )Tj 0.294 0.294 0.29 rg 0.0118 Tc 9.7 0 0 9.7 342.14 593.05 Tm (asthmatic )Tj -0.0117 Tc 4.412 0 Td (than )Tj -0.0186 Tc 2.221 0 Td (in )Tj 0.2 0.204 0.196 rg 0.0087 Tc 1.244 0 Td (normal )Tj 0.384 0.384 0.38 rg 0.0175 Tc 3.352 0 Td (subjects )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.4298 0 0 10.4 488.05 593.05 Tm (\(p>BDC /T1_0 1 Tf 0.0336 Tc 9.7 0 0 9.7 473.678 582.48 Tm (TE)Tj 0 Tc 5.9001 0 0 5.9001 485.74 579.12 Tm (4 )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf -0.0324 Tc 9.7 0 0 9.7 493.42 582.48 Tm (to )Tj -0.0209 Tc 1.138 0 Td (meth)Tj 0.459 0.459 0.455 rg 0 Tc 1.97 0 Td (\255)Tj 0.294 0.294 0.29 rg 0.0202 Tc -23.257 -1.138 Td (acholine )Tj -0.035 Tc 9.2582 0 0 9.7 334.96 571.44 Tm (in )Tj 0.0087 Tc 9.7 0 0 9.7 345.11 571.44 Tm (normal )Tj 0.384 0.384 0.38 rg 0.0175 Tc 3.203 0 Td (subjects )Tj 0.294 0.294 0.29 rg 0.0006 Tc 3.675 0 Td (ranged )Tj ET BT /Suspect <>BDC 0.2 0.204 0.196 rg /T1_0 1 Tf -0.035 Tc 8.8589 0 0 9.7 442.46 571.44 Tm (fr)Tj 0.384 0.384 0.38 rg 0.05 Tc 9.9189 0 0 9.7 447.74 571.44 Tm (om )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf 9.7 0 0 9.7 463.64 571.44 Tm (4.4-59.)Tj 0.459 0.459 0.455 rg 0 Tc 3.115 0 Td (2 )Tj 0.384 0.384 0.38 rg -0.0034 Tc 0.836 0 Td (\(georn )Tj 0.294 0.294 0.29 rg -0.0102 Tc -21.022 -1.137 Td (mean )Tj ET BT /Suspect <>BDC 0.384 0.384 0.38 rg /T1_0 1 Tf 0.003 Tc 9.7 0 0 9.7 322.0103 560.4111 Tm (20, )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf 0.029 Tc 9.7 0 0 9.7 336.4633 560.4111 Tm (n=)Tj 0.384 0.384 0.38 rg -0.0096 Tc 1.077 0 Td (6\). )Tj 0.294 0.294 0.29 rg 0.0235 Tc 1.34 0 Td (The )Tj 0.0108 Tc 1.888 0 Td (relative )Tj 0.0104 Tc 3.318 0 Td (potency )Tj 0.05 Tc 10.5727 0 0 9.7 443.9 560.41 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0176 Tc 9.7 0 0 9.7 455.02 560.41 Tm (ttist.amine )Tj EMC ET BT /T1_0 1 Tf -0.0324 Tc 9.7 0 0 9.7 496.3032 560.41 Tm (to )Tj 0 Tc 0.937 0 Td (L )Tj 0.0336 Tc 0.64 0 Td (TE)Tj 0 Tc 6.1 0 0 6.1 523.66 557.05 Tm (4 )Tj -0.035 Tc 9.2582 0 0 9.7 298.48 549.85 Tm (in )Tj -0.0012 Tc 9.7 0 0 9.7 309.59 549.85 Tm (normal )Tj 0.384 0.384 0.38 rg 0.0175 Tc 3.253 0 Td (subjects )Tj 0.2 0.204 0.196 rg 0 Tc 3.774 0 Td (r)Tj 0.384 0.384 0.38 rg 0.0248 Tc 0.288 0 Td (anged )Tj 0.294 0.294 0.29 rg -0.0273 Tc 2.968 0 Td (from )Tj 0.384 0.384 0.38 rg 0.05 Tc 9.776 0 0 9.7 431.46 549.85 Tm (28 )Tj 0.294 0.294 0.29 rg 0.0171 Tc 9.7 0 0 9.7 445.9 549.85 Tm (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0032 Tc 9.7 0 0 9.7 458.0638 549.85 Tm (107 )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf -0.0026 Tc 9.7 0 0 9.7 476.5326 549.85 Tm (\(geom )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf -0.0102 Tc 9.7 0 0 9.7 505.9042 549.85 Tm (mean )Tj EMC ET BT /T1_0 1 Tf 0.0107 Tc 9.7 0 0 9.7 297.9556 538.8017 Tm (58, )Tj -0.0037 Tc 1.645 0 Td (n=6\). )Tj 0.0072 Tc 2.572 0 Td (Asthmatic )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0175 Tc 9.7 0 0 9.7 382.8985 538.8017 Tm (subjects )Tj EMC ET BT /T1_0 1 Tf 0.0473 Tc 9.7 0 0 9.7 418.546 538.8017 Tm (were )Tj 0.384 0.384 0.38 rg 0.05 Tc 9.776 0 0 9.7 441.54 538.8 Tm (26 )Tj 0.294 0.294 0.29 rg 0.0042 Tc 9.7 0 0 9.7 455.5 538.8 Tm (times )Tj 0.0264 Tc 2.573 0 Td (more )Tj ET BT /Suspect <>BDC 0.384 0.384 0.38 rg /T1_0 1 Tf 0.0139 Tc 9.7 0 0 9.7 503.8545 538.8 Tm (sensi\255)Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf -0.0062 Tc 9.7 0 0 9.7 298.0593 528.2367 Tm (tiv)Tj 0.384 0.384 0.38 rg 0 Tc 1.031 0 Td (e )Tj ET BT /Suspect <>BDC 0.2 0.204 0.196 rg /T1_1 1 Tf -0.035 Tc 7.2775 0 0 7.6 316.57 528.24 Tm (10 )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf 0.0313 Tc 9.7 0 0 9.7 327.31 528.24 Tm (LTE)Tj 0 Tc 5.5001 0 0 5.5001 345.58 525.36 Tm (4 )Tj 0.2 0.204 0.196 rg -0.0117 Tc 9.7 0 0 9.7 353.74 528.24 Tm (than )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf -0.0012 Tc 9.7 0 0 9.7 374.3913 528.24 Tm (normal )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf 0.0192 Tc 9.7 0 0 9.7 405.9454 528.24 Tm (subjec)Tj 0.2 0.204 0.196 rg 0 Tc 2.685 0 Td (t)Tj 0.384 0.384 0.38 rg 0.235 0 Td (s )Tj 0.294 0.294 0.29 rg 0.0243 Tc 0.805 0 Td (whereas )Tj 0.0048 Tc 3.809 0 Td (they )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0143 Tc 9.7 0 0 9.7 499.6765 528.24 Tm (were )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 522.1514 528.24 Tm (7 )Tj 0.2 0.204 0.196 rg -0.021 Tc -23.101 -1.089 Td (tim)Tj 0.384 0.384 0.38 rg 0.029 Tc 1.328 0 Td (es )Tj 0.2 0.204 0.196 rg 0.0099 Tc 1.295 0 Td (more )Tj 0.294 0.294 0.29 rg 0.0178 Tc 2.462 0 Td (sensitive )Tj 0.008 Tc 9.2 0 0 9.2 386.38 517.68 Tm (to )Tj 0.2 0.204 0.196 rg 0 Tc 9.7 0 0 9.7 397.9 517.68 Tm (m)Tj 0.384 0.384 0.38 rg 0.0217 Tc 0.784 0 Td (ethacholine )Tj 0.294 0.294 0.29 rg 0.0016 Tc 5.196 0 Td (and )Tj 0.2 0.204 0.196 rg -0.035 Tc 9.1045 0 0 9.7 474.23 517.68 Tm (hi)Tj 0.384 0.384 0.38 rg 0.012 Tc 9.7 0 0 9.7 481.78 517.68 Tm (stamine. )Tj 0.2 0.204 0.196 rg /T1_2 1 Tf -0.0274 Tc 10.5 0 0 10.5 297.87 490.81 Tm (Correlation )Tj 0.05 Tc 11.3026 0 0 10.5 347.91 490.81 Tm (of )Tj -0.023 Tc 10.5 0 0 10.5 358.97 490.81 Tm (airways )Tj -0.0214 Tc 3.338 0 Td (responsiveness )Tj -0.035 Tc 9.7843 0 0 10.5 457.32 490.81 Tm (to )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.05 Tc 10.6558 0 0 10.5 467.63 490.81 Tm (LT\243)Tj 0 Tc 6.6 0 0 6.6 485.22 487.44 Tm (4 )Tj EMC ET BT /T1_2 1 Tf -0.0226 Tc 10.5 0 0 10.5 491.47 490.81 Tm (with )Tj -0.0131 Tc 1.959 0 Td (that )Tj -0.035 Tc 9.7843 0 0 10.5 297.96 479.76 Tm (to )Tj -0.0222 Tc 10.5 0 0 10.5 309.07 479.76 Tm (methacholine )Tj -0.0142 Tc 5.484 0 Td (and )Tj -0.0207 Tc 1.784 0 Td (histamine )Tj 0.294 0.294 0.29 rg /T1_0 1 Tf 0.028 Tc 9.7 0 0 9.7 306.64 458.16 Tm (There )Tj 0.017 Tc 2.828 0 Td (was )Tj 0 Tc 1.97 0 Td (a )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0089 Tc 9.7 0 0 9.7 361.93 458.16 Tm (positive )Tj EMC ET BT 0.384 0.384 0.38 rg /T1_0 1 Tf 0.0197 Tc 9.7 0 0 9.7 396.8694 458.16 Tm (correlation )Tj 0.0301 Tc 4.959 0 Td (belwee)Tj 0.2 0.204 0.196 rg 0 Tc 2.918 0 Td (n )Tj 0.0066 Tc 0.936 0 Td (LTE )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_0 1 Tf 0.05 Tc 9.8732 0 0 9.7 507.32 458.16 Tm (PD)Tj 0 Tc 6.8001 0 0 6.8001 520.24 454.33 Tm (3)Tj 0.459 0.459 0.455 rg 0.563 0 Td (5 )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf 0.0016 Tc 9.7 0 0 9.7 297.5 447.12 Tm (and )Tj 0.0107 Tc 1.889 0 Td (methacholine )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.8732 0 0 9.7 372.44 447.12 Tm (PD)Tj 0.0108 Tc 6.9001 0 0 6.9001 385.36 443.76 Tm (31 )Tj EMC /Suspect <>BDC 0.384 0.384 0.38 rg 0.0151 Tc 9.7 0 0 9.7 396.37 447.12 Tm (\(r=0.84, )Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg -0.035 Tc 9.467 0 0 10.4 432.49 447.12 Tm (p>BDC 0.384 0.384 0.38 rg /T1_0 1 Tf 0.0021 Tc 9.7 0 0 9.7 499.087 447.12 Tm (\(fig. )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf -0.035 Tc 9.2486 0 0 9.7 520 447.12 Tm (1\) )Tj 0.0016 Tc 9.7 0 0 9.7 297.5 436.09 Tm (and )Tj 0.0078 Tc 2.04 0 Td (between )Tj 0 Tc 3.953 0 Td (L )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.3387 0 0 9.7 360.87 436.09 Tm (TE)Tj 0 Tc 6.4001 0 0 6.4001 372.93 432.72 Tm (4 )Tj EMC /Suspect <>BDC /C0_0 1 Tf 5.0401 0 0 7.68 381.61 436.09 Tm <00500044007E00730020>Tj EMC ET BT /T1_0 1 Tf 0.0016 Tc 9.7 0 0 9.7 406.94 436.09 Tm (and )Tj 0.0161 Tc 2.038 0 Td (histamine )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0239 Tc 9.7 0 0 9.7 470.3586 436.09 Tm (PD)Tj 0.05 Tc 7.107 0 0 6.4001 482.8 432.72 Tm (35 )Tj EMC /Suspect <>BDC 0.384 0.384 0.38 rg 0.008 Tc 9.7 0 0 9.7 495.25 436.09 Tm (\(r=0.79, )Tj EMC /Suspect <>BDC 0.294 0.294 0.29 rg -0.035 Tc 9.3391 0 0 10.4 298.09 425.53 Tm (p>BDC 0.2 0.204 0.196 rg /T1_1 1 Tf -0.0153 Tc 7.9001 0 0 7.9001 325.74 387.61 Tm (PD)Tj /T1_0 1 Tf 0.05 Tc 5.2118 0 0 5.1 336.9 384.72 Tm (35 )Tj EMC ET BT 0.114 0.114 0.11 rg /T1_1 1 Tf 0 Tc 7.9001 0 0 7.9001 346.39 387.61 Tm (L )Tj ET BT /Suspect <>BDC 0.2 0.204 0.196 rg /T1_1 1 Tf 0.0131 Tc 7.9001 0 0 7.9001 350.8299 387.61 Tm (TE)Tj /T1_0 1 Tf 0 Tc 5.1 0 0 5.1 360.94 384.72 Tm (4 )Tj EMC ET BT /T1_1 1 Tf 0.0468 Tc 7.9001 0 0 7.9001 370.9 387.61 Tm (\(nmol\) )Tj ET BT /Suspect <>BDC 0.294 0.294 0.29 rg /T1_1 1 Tf -0.001 Tc 5.4001 0 0 5.4001 304.63 379.44 Tm (1000 )Tj EMC /Suspect <>BDC 0.05 Tc 5.2359 0 0 5.1 307.14 356.89 Tm (300 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 6.4001 0 0 6.4001 457.86 345.84 Tm (0 )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0098 Tc 5.1 0 0 5.1 307.52 332.89 Tm (100 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 6.4001 0 0 6.4001 466.02 331.44 Tm (0 )Tj 0.75 -2.773 Td (0 )Tj ET BT /Suspect <>BDC /C0_0 1 Tf 6.24 0 0 3.84 309.61 307.44 Tm <007E0020>Tj EMC ET BT 0.114 0.114 0.11 rg /T1_0 1 Tf 31.6 0 0 31.6 457.25 307.44 Tm (. )Tj ET BT /Suspect <>BDC 0.459 0.459 0.455 rg /T1_1 1 Tf 5.1 0 0 5.1 310.4 283.93 Tm (1)Tj 0.674 0.674 0.667 rg 0.396 0 Td (0 )Tj EMC /Suspect <>BDC /C0_0 1 Tf 2.88 0 0 4.32 308.65 259.93 Tm <007E>Tj 0.577 0.58 0.572 rg 1.497 0 Td <00300020>Tj EMC /Suspect <>BDC 0.2 0.204 0.196 rg /T1_1 1 Tf 0.05 Tc 6.255 0 0 5.1 308.92 235.93 Tm (10 )Tj EMC /Suspect <>BDC 0.384 0.384 0.38 rg /T1_0 1 Tf 7.0012 0 0 5.8001 308.09 210.49 Tm (03 )Tj EMC /Suspect <>BDC 0.674 0.674 0.667 rg /T1_1 1 Tf 6.3439 0 0 5.1 307.61 186.49 Tm (01 )Tj EMC /Suspect <>BDC 0.384 0.384 0.38 rg /T1_0 1 Tf 6.9945 0 0 5.7 304.73 161.52 Tm (003 )Tj EMC /Suspect <>BDC 0.674 0.674 0.667 rg /T1_3 1 Tf 7.4701 0 0 5.7 304.72 136.57 Tm (00)Tj 0.459 0.459 0.455 rg 0 Tc 5.7 0 0 5.7 313.33 136.57 Tm (1)Tj 0.674 0.674 0.667 rg 0.05 Tc 20.6051 0 0 5.7 318.09 136.57 Tm (----)Tj EMC /Suspect <>BDC 0.114 0.114 0.11 rg /T1_1 1 Tf 0.002 Tc 7.9001 0 0 7.9001 370.89 268.09 Tm (r=0.84 )Tj EMC /Suspect <>BDC -0.014 Tc 0 -1.277 TD (p<0.001 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0 Tc 14.2 0 0 14.2 372.73 170.65 Tm (\225 )Tj EMC /Suspect <>BDC 1.961 2.366 Td (\225 )Tj EMC /Suspect <>BDC /T1_1 1 Tf 13 0 0 13 415.96 282.49 Tm (\225 )Tj EMC /Suspect <>BDC 13.1 0 0 13.1 421.72 242.16 Tm (\225 )Tj EMC /Suspect <>BDC 0.2 0.204 0.196 rg /T1_0 1 Tf 14.2 0 0 14.2 408.25 225.85 Tm (\225 )Tj EMC /Suspect <>BDC /T1_1 1 Tf 14 0 0 14 435.14 293.53 Tm (\225 )Tj EMC /Suspect <>BDC 0.114 0.114 0.11 rg /T1_0 1 Tf -0.035 Tc 15.1547 0 0 15.3 457.68 293.53 Tm (\225\225 )Tj EMC /Suspect <>BDC 0 Tc 14.2 0 0 14.2 439.93 279.61 Tm (\225 )Tj EMC /Suspect <>BDC 14.1 0 0 14.1 435.61 271.44 Tm (\225 )Tj EMC /Suspect <>BDC 14.2 0 0 14.2 451.45 271.44 Tm (\225 )Tj EMC /Suspect <>BDC /T1_1 1 Tf 16.8 0 0 16.8 462.46 271.44 Tm (\225 )Tj EMC /Suspect <>BDC -0.035 Tc 10.5932 0 0 14.8 432.8 264.72 Tm (\225\225 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0 Tc 14.1 0 0 14.1 450.01 264.72 Tm (\225 )Tj EMC /Suspect <>BDC -0.919 -0.68 Td (\225 )Tj EMC /Suspect <>BDC 0.2 0.204 0.196 rg 15.1 0 0 15.1 458.64 255.13 Tm (\225 )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf 6.4001 0 0 6.4001 493.86 361.69 Tm (0 )Tj 1.425 -3.902 Td (0 )Tj 0.384 0.384 0.38 rg -2.025 -2.325 Td (0 )Tj ET BT /Suspect <>BDC 0.114 0.114 0.11 rg /T1_1 1 Tf 14 0 0 14 480.26 278.65 Tm (\225 )Tj EMC /Suspect <>BDC 0.674 0.674 0.667 rg /T1_0 1 Tf 0.05 Tc 5.2106 0 0 5 311.47 132.25 Tm (0l"-\)1 )Tj EMC /Suspect <>BDC 0.384 0.384 0.38 rg /T1_2 1 Tf 6.3093 0 0 5.4001 336.85 132.25 Tm (0003 )Tj EMC /Suspect <>BDC 0.674 0.674 0.667 rg /T1_0 1 Tf 5.8523 0 0 5.7 364.3 132.25 Tm (DOl )Tj EMC /Suspect <>BDC 0.459 0.459 0.455 rg 6.9945 0 0 5.7 388.25 132.25 Tm (001 )Tj EMC /Suspect <>BDC 0.384 0.384 0.38 rg 0 Tc 5.2 0 0 5.2 412.27 132.25 Tm (0 )Tj EMC ET BT 0.459 0.459 0.455 rg /T1_0 1 Tf 5 0 0 5 417.43 132.25 Tm (1 )Tj ET BT /Suspect <>BDC 0.674 0.674 0.667 rg /T1_0 1 Tf 5.7 0 0 5.7 435.78 132.25 Tm (0 )Tj EMC ET BT /T1_0 1 Tf 5.7 0 0 5.7 440.5794 132.25 Tm (3 )Tj 0.577 0.58 0.572 rg 5 0 0 5 462.55 132.25 Tm (1 )Tj ET BT /Suspect <>BDC 0.674 0.674 0.667 rg /T1_0 1 Tf 5.7 0 0 5.7 466.02 132.25 Tm (0 )Tj EMC /Suspect <>BDC 0.05 Tc 7.107 0 0 5.7 485.68 132.25 Tm (30 )Tj EMC /Suspect <>BDC 0.459 0.459 0.455 rg 5.3955 0 0 5.2 512.94 132.25 Tm (10 )Tj EMC /Suspect <>BDC 0.114 0.114 0.11 rg /T1_1 1 Tf 0.0349 Tc 7.9001 0 0 7.9001 366.54 117.36 Tm (PO,. )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_1 1 Tf 0.05 Tc 7.9616 0 0 7.9001 390.07 117.36 Tm (Methacholine )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 7.467 0 0 7.9001 444.83 117.36 Tm (\(11mol\) )Tj EMC ET BT /T1_0 1 Tf -0.0281 Tc 8.1 0 0 8.1 296.61 99.6 Tm (Fig. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0243 Tc 8.1 0 0 8.1 314.8188 99.6 Tm (I. )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf 0 Tc 8.1 0 0 8.1 324.8709 99.6 Tm (-)Tj 0.2 0.204 0.196 rg 0.0021 Tc 1.128 0 Td (The )Tj 0.294 0.294 0.29 rg -0.0039 Tc 2.132 0 Td (correlation )Tj 0.2 0.204 0.196 rg -0.0099 Tc 4.989 0 Td (between )Tj 0.294 0.294 0.29 rg 0 Tc 3.905 0 Td (L )Tj 0.2 0.204 0.196 rg -0.0184 Tc 0.589 0 Td (TE)Tj 0 Tc 5.6 0 0 5.6 437.74 96.72 Tm (4 )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 7.7107 0 0 8.6 445.98 99.6 Tm (PD)Tj 0.05 Tc 6.5478 0 0 5.8001 455.46 96.72 Tm (35 )Tj EMC ET BT /T1_0 1 Tf -0.0049 Tc 8.1 0 0 8.1 466.96 99.6 Tm (and )Tj -0.0092 Tc 2.022 0 Td (methacholine )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.041 Tc 8.1 0 0 8.1 296.1148 90.4794 Tm (PD)Tj 0.0119 Tc 6.4001 0 0 6.4001 306.65 87.12 Tm (35)Tj 0 Tc 1.041 0.525 Td (. )Tj EMC /Suspect <>BDC 0.114 0.114 0.11 rg /T1_3 1 Tf 12 0 0 12 317.63 90.48 Tm (e )Tj EMC ET BT 0.294 0.294 0.29 rg /T1_0 1 Tf -0.0102 Tc 8.1 0 0 8.1 327.76 90.48 Tm (asthmatic )Tj -0.0115 Tc 4.144 0 Td (subjects; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.3877 0 0 8.1 393.52 90.48 Tm (Ononnal )Tj EMC ET BT 0.2 0.204 0.196 rg /T1_0 1 Tf -0.0081 Tc 8.1 0 0 8.1 428.53 90.48 Tm (subjects. 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0.239 0.235 rg /T1_0 1 Tf 0.0245 Tc 6.8001 0 0 6.8001 104.0769 748.09 Tm (\(nmol\) )Tj ET BT /Suspect <>BDC 0.165 0.169 0.165 rg /T1_0 1 Tf 0.05 Tc 6.4659 0 0 6.4001 55.94 741.36 Tm (1000 )Tj EMC /Suspect <>BDC 0.239 0.239 0.235 rg 6.4488 0 0 6.4001 58.97 702.97 Tm (300 )Tj EMC /Suspect <>BDC 6.9083 0 0 6.4001 58.8 669.85 Tm (100 )Tj EMC /Suspect <>BDC 0.165 0.169 0.165 rg 7.107 0 0 6.4001 61.84 633.36 Tm (30 )Tj EMC /Suspect <>BDC 6.867 0 0 6.4001 62.16 600.24 Tm (10 )Tj EMC /Suspect <>BDC /T1_1 1 Tf 0 Tc 13.1 0 0 13.1 114.04 594.48 Tm (\225 )Tj EMC /Suspect <>BDC 13 0 0 13 122.68 581.53 Tm (\225 )Tj EMC /Suspect <>BDC -1.698 -0.332 Td (\225 )Tj EMC /Suspect <>BDC 0.239 0.239 0.235 rg /T1_0 1 Tf 0.05 Tc 6.5799 0 0 6.4001 60.41 563.76 Tm (3.0 )Tj EMC /Suspect <>BDC 0.165 0.169 0.165 rg /T1_1 1 Tf 0 Tc 13 0 0 13 134.2 625.21 Tm (\225 )Tj EMC /Suspect <>BDC 0.239 0.239 0.235 rg /T1_0 1 Tf 14.2 0 0 14.2 131.29 612.24 Tm (\225 )Tj EMC /Suspect <>BDC 0.165 0.169 0.165 rg /T1_1 1 Tf 13.1 0 0 13.1 138.04 559.92 Tm (\225 )Tj EMC /Suspect <>BDC 0.392 0.392 0.388 rg /T1_0 1 Tf 5.1 0 0 5.1 255.31 711.61 Tm (0 )Tj EMC /Suspect <>BDC 0.239 0.239 0.235 rg -9.694 -4.706 Td (0 )Tj EMC /Suspect <>BDC 0.333 0.333 0.329 rg -5.647 -2.449 Td (0 )Tj EMC /Suspect <>BDC 0.239 0.239 0.235 rg 5.4001 0 0 5.4001 177.07 667.92 Tm (0 )Tj EMC /Suspect <>BDC 0.333 0.333 0.329 rg 5.1 0 0 5.1 186.67 653.05 Tm (0 )Tj EMC /Suspect <>BDC 0.239 0.239 0.235 rg -0.376 -2.167 Td (0 )Tj EMC /Suspect <>BDC 0.165 0.169 0.165 rg /T1_1 1 Tf 13.1 0 0 13.1 175.48 617.05 Tm (\225 )Tj EMC /Suspect <>BDC 0.239 0.239 0.235 rg /T1_0 1 Tf 0.0375 Tc 6.4001 0 0 6.4001 238.55 594 Tm (t=0.79 )Tj EMC /Suspect <>BDC 0.165 0.169 0.165 rg 0 Tc 14.1 0 0 14.1 170.65 585.85 Tm (\225 )Tj EMC /Suspect <>BDC 0.0368 Tc 6.4001 0 0 6.4001 238.57 580.09 Tm (p<0.001 )Tj EMC /Suspect <>BDC /T1_1 1 Tf 0 Tc 13 0 0 13 165.88 569.05 Tm (\225 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 6.7575 0 0 6.4001 60.73 529.21 Tm (1.0 )Tj EMC /Suspect <>BDC 0.239 0.239 0.235 rg 13.6997 0 0 10.1 75.07 529.21 Tm (.------.-)Tj 0.392 0.392 0.388 rg 18.6712 0 0 10.1 118.82 529.21 Tm (---r----r--)Tj 0.239 0.239 0.235 rg 13.8938 0 0 10.1 196.16 529.21 Tm (---.-----.-)Tj 0.392 0.392 0.388 rg 15.4695 0 0 10.1 251.34 529.21 Tm (-----. )Tj EMC /Suspect <>BDC 0.165 0.169 0.165 rg 0.0233 Tc 6.4001 0 0 6.4001 71.46 521.05 Tm (0.1 )Tj EMC /Suspect <>BDC 4.875 0 Td (0.3 )Tj EMC /Suspect <>BDC 0.239 0.239 0.235 rg 0.0482 Tc 5.75 0 Td (1.0 )Tj EMC /Suspect <>BDC 0.05 Tc 6.5799 0 0 6.4001 172.25 521.53 Tm (3.0 )Tj EMC /Suspect <>BDC 6.867 0 0 6.4001 212.4 521.53 Tm (10 )Tj EMC /Suspect <>BDC 0.165 0.169 0.165 rg 7.107 0 0 6.4001 245.2 521.53 Tm (30 )Tj EMC /Suspect <>BDC 6.5943 0 0 6.4001 280.57 522 Tm (100 )Tj EMC /Suspect <>BDC 0.0477 Tc 6.8001 0 0 6.8001 149.25 509.53 Tm (PO,. )Tj EMC /Suspect <>BDC 0.0353 Tc 2.329 0 Td (Hlslemlne )Tj EMC /Suspect <>BDC -0.035 Tc 5.9896 0 0 6.4001 197.52 509.53 Tm ({JUnOI\) )Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf -0.0121 Tc 9.1 0 0 9.1 56.6 484.09 Tm (Fig. )Tj -0.0162 Tc 9.4 0 0 9.4 74.82 484.09 Tm (2. )Tj 0.333 0.333 0.329 rg 0.05 Tc 11.4513 0 0 9.1 85.31 484.09 Tm (-The )Tj 0.239 0.239 0.235 rg -0.0033 Tc 9.1 0 0 9.1 112.23 484.09 Tm (correlation )Tj 0.0008 Tc 4.758 0 Td (between )Tj ET BT /Suspect <>BDC 0.165 0.169 0.165 rg /C0_0 1 Tf 0 Tc 4.9201 0 0 6.72 189.61 484.09 Tm <004C00540045007E0020>Tj EMC /Suspect <>BDC 4.64 0 0 6.72 213.61 484.09 Tm <00500044007E>Tj 0.333 0.333 0.329 rg 2.88 0 0 10.08 228 480.72 Tm <00350020>Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf -0.0303 Tc 9.1 0 0 9.1 235.11 484.09 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0213 Tc 8.9 0 0 8.9 251.51 484.09 Tm (hislam.ine )Tj EMC /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 8.8122 0 0 10 56.71 474.49 Tm (PD)Tj -0.0163 Tc 6.5001 0 0 6.5001 68.1 471.12 Tm (35)Tj 0 Tc 1.034 0.518 Td (. )Tj EMC /Suspect <>BDC 0.165 0.169 0.165 rg /T1_0 1 Tf 0.88 0 Td (\225 )Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf -0.0021 Tc 9.1 0 0 9.1 93.51 474.49 Tm (asthmatic )Tj -0.0051 Tc 4.163 0 Td (subjects; )Tj ET BT /Suspect <>BDC 0.333 0.333 0.329 rg /T1_0 1 Tf 0 Tc 9.1 0 0 9.1 171.2695 474.49 Tm (0 )Tj EMC /Suspect <>BDC 0.239 0.239 0.235 rg -0.0062 Tc 1.327 0 Td (normal )Tj EMC ET BT /T1_0 1 Tf -0.0018 Tc 9.1 0 0 9.1 212.0284 474.49 Tm (subjects. )Tj 0.165 0.169 0.165 rg -0.0304 Tc 10.9 0 0 10.9 153.55 454.33 Tm (Discussion )Tj -0.0211 Tc 10.6 0 0 10.6 65.19 432.25 Tm (The )Tj ET BT /Suspect <>BDC 0.239 0.239 0.235 rg /T1_0 1 Tf -0.0254 Tc 10.6 0 0 10.6 85.33 432.25 Tm (airways )Tj EMC ET BT 0.165 0.169 0.165 rg /T1_0 1 Tf -0.0222 Tc 10.6 0 0 10.6 120.9354 432.25 Tm (responsiveness )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.3833 0 0 10.6 186.21 432.25 Tm (to )Tj 0.165 0.169 0.165 rg -0.0259 Tc 10.6 0 0 10.6 198.18 432.25 Tm (LTE)Tj 0 Tc 6.2 0 0 6.2 216.46 428.89 Tm (4 )Tj -0.035 Tc 10.3013 0 0 10.6 225.11 432.25 Tm (has )Tj 10.568 0 0 10.6 242.41 432.25 Tm (been )Tj 0.239 0.239 0.235 rg 10.4568 0 0 10.6 265.82 432.25 Tm (com\255)Tj 0.165 0.169 0.165 rg -0.0204 Tc 10.6 0 0 10.6 56.18 421.21 Tm (pared )Tj 0.239 0.239 0.235 rg 0.0424 Tc 9.4 0 0 9.4 83.02 421.21 Tm (to )Tj 0.0351 Tc 9.6 0 0 9.6 95.02 421.21 Tm (that )Tj 0.165 0.169 0.165 rg 0.0478 Tc 10.6 0 0 10.6 113.66 421.21 Tm (of )Tj -0.0264 Tc 1.23 0 Td (histamine )Tj 0.239 0.239 0.235 rg -0.0141 Tc 4.022 0 Td (and )Tj 0.165 0.169 0.165 rg -0.0235 Tc 1.775 0 Td (methacholine )Tj 0.239 0.239 0.235 rg -0.035 Tc 9.9195 0 0 10.6 246.64 421.21 Tm (in )Tj 0.165 0.169 0.165 rg -0.009 Tc 10.6 0 0 10.6 258.23 421.21 Tm (nonnal )Tj 0.239 0.239 0.235 rg 0.0312 Tc -19.074 -0.996 Td (and )Tj -0.024 Tc 1.857 0 Td (asthmatic )Tj -0.0285 Tc 4.072 0 Td (subjects. )Tj -0.0275 Tc 3.725 0 Td (Airways )Tj 0.165 0.169 0.165 rg -0.0222 Tc 3.623 0 Td (responsiveness )Tj -0.035 Tc 9.7344 0 0 10.6 262.54 410.65 Tm (to )Tj 10.0379 0 0 10.6 275.02 410.65 Tm (the )Tj 0.239 0.239 0.235 rg -0.0226 Tc 10.6 0 0 10.6 56.65 399.61 Tm (bronchoconstrictor )Tj -0.0282 Tc 7.506 0 Td (agents )Tj -0.035 Tc 10.3816 0 0 10.6 165.59 399.61 Tm (was )Tj -0.0227 Tc 10.6 0 0 10.6 185.17 399.61 Tm (assessed )Tj 0.165 0.169 0.165 rg -0.035 Tc 9.5458 0 0 10.6 223.69 399.61 Tm (by )Tj 0.239 0.239 0.235 rg -0.0232 Tc 10.6 0 0 10.6 237.02 399.61 Tm (constructing )Tj -0.0178 Tc -17.072 -0.996 Td (cumulative )Tj -0.0258 Tc 4.755 0 Td (dose-response )Tj -0.0285 Tc 5.887 0 Td (curves )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.5732 0 0 10.6 200.53 389.05 Tm (and )Tj 10.4562 0 0 10.6 220.77 389.05 Tm (the )Tj 0.239 0.239 0.235 rg -0.0341 Tc 10.6 0 0 10.6 238.46 389.05 Tm (dose )Tj 0.165 0.169 0.165 rg -0.032 Tc 2.226 0 Td (which )Tj 0.239 0.239 0.235 rg -0.0254 Tc -19.423 -1.042 Td (produced )Tj 0 Tc 3.973 0 Td (a )Tj -0.035 Tc 10.5672 0 0 10.6 107.4 378 Tm (35% )Tj -0.0239 Tc 10.6 0 0 10.6 130.46 378 Tm (decrease )Tj 0.165 0.169 0.165 rg -0.035 Tc 9.9195 0 0 10.6 170.32 378 Tm (in )Tj 0.239 0.239 0.235 rg -0.0195 Tc 10.6 0 0 10.6 182.25 378 Tm (specific )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0254 Tc 10.6 0 0 10.6 218.29 378 Tm (airways )Tj EMC ET BT /T1_0 1 Tf -0.02 Tc 10.6 0 0 10.6 253.8212 378 Tm (conduc\255)Tj -0.035 Tc 10.5111 0 0 10.6 56.61 366.97 Tm (tance )Tj -0.0262 Tc 10.6 0 0 10.6 80.51 366.97 Tm (\(PD)Tj 0.0251 Tc 6.8001 0 0 6.8001 96.88 363.12 Tm (35)Tj 0 Tc 0.994 0.566 Td (\) )Tj -0.035 Tc 10.3816 0 0 10.6 110.87 366.97 Tm (was )Tj -0.0227 Tc 10.6 0 0 10.6 129.5 366.97 Tm (obtained )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.3382 0 0 10.6 167.41 366.97 Tm (from )Tj 9.7344 0 0 10.6 190.54 366.97 Tm (th)Tj 0.333 0.333 0.329 rg 0 Tc 10.6 0 0 10.6 198.13 366.97 Tm (e )Tj 0.239 0.239 0.235 rg -0.0189 Tc 0.721 0 Td (straight-line )Tj -0.0193 Tc 4.861 0 Td (portion )Tj 0.0478 Tc -18.985 -1.042 Td (of )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.4562 0 0 10.6 69.09 355.93 Tm (the )Tj -0.0196 Tc 10.6 0 0 10.6 85.35 355.93 Tm (log )Tj -0.022 Tc 1.629 0 Td (dose-response )Tj 0.239 0.239 0.235 rg -0.0177 Tc 5.796 0 Td (curve )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.5506 0 0 10.6 191.05 355.93 Tm (by )Tj -0.0259 Tc 10.6 0 0 10.6 205.83 355.93 Tm (linear )Tj 0.239 0.239 0.235 rg -0.024 Tc 2.536 0 Td (interpolation. )Tj -0.0211 Tc -16.709 -1.042 Td (The )Tj 0.165 0.169 0.165 rg -0.0232 Tc 1.776 0 Td (potencies )Tj 0.05 Tc 11.1292 0 0 10.6 115.09 344.89 Tm (of )Tj -0.0295 Tc 10.6 0 0 10.6 126.13 344.89 Tm (each )Tj 0.239 0.239 0.235 rg -0.0172 Tc 1.992 0 Td (agent )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.483 0 0 10.6 172.79 344.89 Tm (were )Tj 0.239 0.239 0.235 rg -0.0164 Tc 10.6 0 0 10.6 194.73 344.89 Tm (studied )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.0482 0 0 10.6 227.05 344.89 Tm (by )Tj 0.239 0.239 0.235 rg -0.0277 Tc 10.6 0 0 10.6 239.42 344.89 Tm (comparison )Tj 0.0478 Tc -17.343 -0.996 Td (of )Tj -0.0201 Tc 1.139 0 Td (the )Tj ET BT /Suspect <>BDC 0.165 0.169 0.165 rg /T1_2 1 Tf -0.0246 Tc 10.2 0 0 10.2 83.12 334.33 Tm (PD)Tj 0.05 Tc 7.0155 0 0 6.5001 95.94 330.97 Tm (35 )Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf -0.035 Tc 10.5781 0 0 10.6 107.02 334.33 Tm (values. )Tj -0.0259 Tc 10.6 0 0 10.6 64.74 323.28 Tm (LTE)Tj 0 Tc 6.2 0 0 6.2 82.54 319.93 Tm (4 )Tj -0.0285 Tc 10.6 0 0 10.6 89.65 323.28 Tm (enhances )Tj -0.0176 Tc 3.725 0 Td (bronchial )Tj 0.165 0.169 0.165 rg -0.0241 Tc 3.846 0 Td (hyperresponsiveness )Tj -0.035 Tc 9.9195 0 0 10.6 256.24 323.28 Tm (in )Tj 0.239 0.239 0.235 rg -0.0299 Tc 10.6 0 0 10.6 266.77 323.28 Tm (asth\255)Tj -0.0324 Tc -19.916 -0.996 Td (matic )Tj -0.0227 Tc 2.433 0 Td (subjects )Tj 0.333 0.333 0.329 rg -0.0286 Tc 3.431 0 Td ([13], )Tj 0.239 0.239 0.235 rg -0.035 Tc 9.7344 0 0 10.6 140.14 312.72 Tm (th)Tj 0.392 0.392 0.388 rg 0 Tc 10.6 0 0 10.6 147.73 312.72 Tm (e)Tj 0.239 0.239 0.235 rg 0.461 0 Td (r)Tj 0.392 0.392 0.388 rg 0.263 0 Td (e )Tj 0.165 0.169 0.165 rg 0.817 0 Td (i)Tj 0.392 0.392 0.388 rg 0.221 0 Td (s )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.5587 0 0 10.6 174.25 312.72 Tm (bioconv)Tj 0.392 0.392 0.388 rg 0 Tc 10.6 0 0 10.6 206.29 312.72 Tm (e)Tj 0.239 0.239 0.235 rg 0.371 0 Td (r)Tj 0.392 0.392 0.388 rg 0.35 0 Td (s)Tj 0.239 0.239 0.235 rg -0.035 Tc 10.0769 0 0 10.6 218.32 312.72 Tm (ion )Tj 0.333 0.333 0.329 rg 0.0478 Tc 10.6 0 0 10.6 234.14 312.72 Tm (of )Tj -0.0312 Tc 1.091 0 Td (LTC)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 264.46 308.89 Tm (4 )Tj /T1_0 1 Tf -0.035 Tc 10.2207 0 0 10.6 271.58 312.72 Tm (and )Tj 0.239 0.239 0.235 rg 10.5821 0 0 10.6 55.14 301.69 Tm (LTD)Tj 0 Tc 6.4001 0 0 6.4001 74.38 298.33 Tm (4 )Tj 0.165 0.169 0.165 rg -0.035 Tc 9.7344 0 0 10.6 81.1 301.69 Tm (to )Tj 0.239 0.239 0.235 rg -0.0259 Tc 10.6 0 0 10.6 90.66 301.69 Tm (LTE)Tj 0 Tc 6.4001 0 0 6.4001 108.93 297.84 Tm (4 )Tj -0.0311 Tc 10.6 0 0 10.6 115.1 301.69 Tm (during )Tj 0.333 0.333 0.329 rg 0 Tc 2.716 0 Td (a )Tj -0.0253 Tc 0.635 0 Td (contractile )Tj 0.239 0.239 0.235 rg -0.0207 Tc 4.128 0 Td (rea)Tj 0.392 0.392 0.388 rg -0.0244 Tc 1.17 0 Td (ctio)Tj 0.239 0.239 0.235 rg 0 Tc 1.458 0 Td (n )Tj 0.333 0.333 0.329 rg -0.035 Tc 10.0682 0 0 10.6 229.68 301.69 Tm ([16\) )Tj 10.2207 0 0 10.6 248.06 301.69 Tm (and )Tj 10.4363 0 0 10.6 264.9 301.69 Tm (LTE )Tj 0.239 0.239 0.235 rg 10.5011 0 0 10.6 55.66 290.65 Tm (may )Tj -0.0181 Tc 10.6 0 0 10.6 76.34 290.65 Tm (persist )Tj 0.0156 Tc 2.795 0 Td (at )Tj -0.035 Tc 9.7344 0 0 10.6 117.1 290.65 Tm (th)Tj 0.392 0.392 0.388 rg 0 Tc 10.6 0 0 10.6 124.69 290.65 Tm [(e )-27(s)]TJ 0.239 0.239 0.235 rg -0.035 Tc 10.5002 0 0 10.6 136.71 290.65 Tm (it)Tj 0.392 0.392 0.388 rg 0 Tc 10.6 0 0 10.6 141.97 290.65 Tm (e )Tj 0.333 0.333 0.329 rg 0.0025 Tc 0.771 0 Td (of )Tj 0.239 0.239 0.235 rg 0 Tc 1.14 0 Td (r)Tj 0.392 0.392 0.388 rg 0.263 0 Td (e)Tj 0.239 0.239 0.235 rg -0.0305 Tc 0.409 0 Td (lea)Tj 0.392 0.392 0.388 rg -0.035 Tc 10.5734 0 0 10.6 181.29 290.65 Tm (se )Tj 0.333 0.333 0.329 rg -0.0266 Tc 10.6 0 0 10.6 193.32 290.65 Tm (for )Tj 0.239 0.239 0.235 rg 0 Tc 1.405 0 Td (a )Tj 0.333 0.333 0.329 rg -0.035 Tc 10.1333 0 0 10.6 216.98 290.65 Tm (prol.ongcd )Tj 0.239 0.239 0.235 rg 10.007 0 0 10.6 261.14 290.65 Tm (peri)Tj 0.392 0.392 0.388 rg 10.1631 0 0 10.6 275.9 290.65 Tm (od )Tj 0.239 0.239 0.235 rg 0.05 Tc 11.1292 0 0 10.6 55.09 279.61 Tm (of )Tj -0.0321 Tc 10.6 0 0 10.6 67.65 279.61 Tm (time )Tj 0.333 0.333 0.329 rg -0.035 Tc 10.4792 0 0 10.6 89.51 279.61 Tm ([17\). )Tj -0.0254 Tc 10.6 0 0 10.6 112.13 279.61 Tm (Since )Tj 0.239 0.239 0.235 rg -0.035 Tc 9.7344 0 0 10.6 138.7 279.61 Tm (th)Tj 0.392 0.392 0.388 rg 0 Tc 10.6 0 0 10.6 145.81 279.61 Tm (e)Tj 0.239 0.239 0.235 rg -0.035 Tc 10.3686 0 0 10.6 150.71 279.61 Tm (re )Tj 0 Tc 10.6 0 0 10.6 162.63 279.61 Tm (i)Tj 0.392 0.392 0.388 rg 0.221 0 Td (s )Tj 0.239 0.239 0.235 rg -0.035 Tc 9.8308 0 0 10.6 172.81 279.61 Tm (bi)Tj 0.392 0.392 0.388 rg -0.0321 Tc 10.6 0 0 10.6 180.38 279.61 Tm (oco)Tj 0.239 0.239 0.235 rg -0.0349 Tc 1.412 0 Td (nversi)Tj 0.392 0.392 0.388 rg 0 Tc 2.256 0 Td (o)Tj 0.239 0.239 0.235 rg 0.507 0 Td (n )Tj 0.333 0.333 0.329 rg 0.0478 Tc 0.807 0 Td (of )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.3784 0 0 10.6 245.22 279.61 Tm (LTC)Tj 0 Tc 6.2 0 0 6.2 263.98 276.25 Tm (4 )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.5732 0 0 10.6 271.57 279.61 Tm (and )Tj 10.5821 0 0 10.6 55.14 269.05 Tm (LTD)Tj 0 Tc 6.1 0 0 6.1 74.86 265.21 Tm (4 )Tj -0.035 Tc 10.3833 0 0 10.6 83.97 269.05 Tm (to )Tj 0.333 0.333 0.329 rg 0 Tc 10.6 0 0 10.6 96.42 269.05 Tm (L )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0262 Tc 10.6 0 0 10.6 102.6316 269.05 Tm (TE)Tj 0 Tc 6.1 0 0 6.1 114.7 265.69 Tm (4)Tj 0.697 0.551 Td (, )Tj EMC ET BT 0.239 0.239 0.235 rg /T1_1 1 Tf -0.0179 Tc 9.8 0 0 9.8 127.01 269.05 Tm (it )Tj /T1_0 1 Tf -0.035 Tc 9.3682 0 0 10.6 137.68 269.05 Tm (is )Tj 7.3578 0 0 10.6 149.72 269.05 Tm (Lik)Tj 0.392 0.392 0.388 rg 0 Tc 10.6 0 0 10.6 159.73 269.05 Tm (e)Tj 0.239 0.239 0.235 rg -0.035 Tc 9.9071 0 0 10.6 164.56 269.05 Tm (ly )Tj -0.0303 Tc 10.6 0 0 10.6 177.57 269.05 Tm (that )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0259 Tc 10.6 0 0 10.6 196.7348 269.05 Tm (LTE)Tj 0 Tc 6.1 0 0 6.1 215.5 265.21 Tm (4 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.308 0 0 10.6 224.63 269.05 Tm (will )Tj -0.0251 Tc 10.6 0 0 10.6 245.18 269.05 Tm (contribute )Tj 0.333 0.333 0.329 rg -0.027 Tc -17.937 -1.042 Td (sig)Tj 0.165 0.169 0.165 rg -0.035 Tc 10.5107 0 0 10.6 67.19 258 Tm (nifi)Tj 0.333 0.333 0.329 rg -0.0221 Tc 10.6 0 0 10.6 80.54 258 Tm (cantly )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.3833 0 0 10.6 109.41 258 Tm (to )Tj -0.0094 Tc 10.6 0 0 10.6 120.37 258 Tm (airnow )Tj 0.333 0.333 0.329 rg -0.0192 Tc 3.08 0 Td (obstr)Tj 0.165 0.169 0.165 rg 0 Tc 1.957 0 Td (u)Tj 0.392 0.392 0.388 rg 0.398 0 Td (c)Tj 0.239 0.239 0.235 rg -0.035 Tc 10.2859 0 0 10.6 183.33 258 Tm (tion )Tj ET BT /Suspect <>BDC 0.333 0.333 0.329 rg /T1_0 1 Tf 0.05 Tc 10.7518 0 0 10.6 201.97 258 Tm (at )Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf -0.0201 Tc 10.6 0 0 10.6 213.09 258 Tm (the )Tj 0.392 0.392 0.388 rg 0 Tc 1.483 0 Td (s)Tj 0.239 0.239 0.235 rg -0.035 Tc 10.5002 0 0 10.6 233.19 258 Tm (it)Tj 0.392 0.392 0.388 rg 0 Tc 10.6 0 0 10.6 237.97 258 Tm (e )Tj 0.239 0.239 0.235 rg 0.0478 Tc 0.771 0 Td (of )Tj -0.024 Tc 1.14 0 Td (release )Tj 0.0478 Tc -19.162 -1.086 Td (of )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.0379 0 0 10.6 66.22 246.49 Tm (the )Tj 0.239 0.239 0.235 rg -0.0304 Tc 10.6 0 0 10.6 80.01 246.49 Tm (sulphidopeptide )Tj -0.0339 Tc 6.164 0 Td (leukotrienes. )Tj ET BT /Suspect <>BDC 0.165 0.169 0.165 rg /T1_0 1 Tf -0.0192 Tc 10.6 0 0 10.6 197.6488 246.49 Tm (Our )Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf -0.035 Tc 10.5359 0 0 10.6 215.9 246.49 Tm (data )Tj 10.5311 0 0 10.6 234.62 246.49 Tm (demonstrates )Tj -0.0152 Tc 10.6 0 0 10.6 55.17 235.93 Tm (that )Tj 0 Tc 1.673 0 Td (L )Tj -0.035 Tc 10.2692 0 0 10.6 79.11 235.93 Tm (TE)Tj /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 91.18 232.09 Tm (4 )Tj 0.165 0.169 0.165 rg /T1_0 1 Tf -0.0159 Tc 10.6 0 0 10.6 97.83 235.93 Tm (is )Tj 0.239 0.239 0.235 rg 0 Tc 0.904 0 Td (a )Tj 0.165 0.169 0.165 rg -0.0176 Tc 0.692 0 Td (potent )Tj 0.239 0.239 0.235 rg -0.0199 Tc 2.671 0 Td (bronchoconstrictor )Tj -0.0059 Tc 7.415 0 Td (agent )Tj -0.035 Tc 9.2582 0 0 10.6 247.12 235.93 Tm (in )Tj 0.165 0.169 0.165 rg -0.0271 Tc 10.6 0 0 10.6 257.75 235.93 Tm (nonnal )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.2207 0 0 10.6 55.1 224.89 Tm (and )Tj 10.5914 0 0 10.6 71.89 224.89 Tm (asthmatic )Tj -0.0292 Tc 10.6 0 0 10.6 111.69 224.89 Tm (subjects )Tj -0.0141 Tc 3.219 0 Td (and )Tj -0.0323 Tc 1.586 0 Td (confirms )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.4562 0 0 10.6 200.13 224.89 Tm (the )Tj 10.1154 0 0 10.6 215.03 224.89 Tm (work )Tj 0.239 0.239 0.235 rg 0.0478 Tc 10.6 0 0 10.6 237.02 224.89 Tm (of )Tj 0.165 0.169 0.165 rg -0.035 Tc 8.618 0 0 10.6 247.64 224.89 Tm (DA )Tj ET BT /Suspect <>BDC 0.239 0.239 0.235 rg /T1_0 1 Tf 9.5532 0 0 10.6 259.66 224.89 Tm (vrosoN )Tj EMC ET BT /T1_2 1 Tf 0.05 Tc 10.6747 0 0 9.9 55.1 213.85 Tm (eta/. )Tj /T1_0 1 Tf -0.0286 Tc 10.6 0 0 10.6 80.38 213.85 Tm ([11]. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0184 Tc 10.6 0 0 10.6 103.1912 213.85 Tm (Using )Tj EMC ET BT /T1_0 1 Tf -0.0257 Tc 10.6 0 0 10.6 130.889 213.85 Tm (sGaw )Tj -0.035 Tc 10.3825 0 0 10.6 157.81 213.85 Tm (as )Tj 0.165 0.169 0.165 rg 10.4562 0 0 10.6 170.37 213.85 Tm (the )Tj 0.239 0.239 0.235 rg 10.4659 0 0 10.6 186.63 213.85 Tm (index )Tj 0.0478 Tc 10.6 0 0 10.6 212.54 213.85 Tm (of )Tj -0.0252 Tc 1.131 0 Td (airway )Tj -0.0198 Tc 2.944 0 Td (calibre, )Tj -0.035 Tc 10.235 0 0 10.6 55.19 203.29 Tm (we )Tj -0.0333 Tc 10.6 0 0 10.6 69.48 203.29 Tm (found )Tj -0.0152 Tc 2.544 0 Td (that )Tj 0 Tc 1.627 0 Td (L )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.2692 0 0 10.6 120.39 203.29 Tm (TE)Tj 0 Tc 6.1 0 0 6.1 132.94 199.44 Tm (4 )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.3816 0 0 10.6 139.67 203.29 Tm (was )Tj -0.0287 Tc 10.6 0 0 10.6 157.82 203.29 Tm (on )Tj 0.165 0.169 0.165 rg -0.0175 Tc 1.267 0 Td (average )Tj 0.239 0.239 0.235 rg -0.016 Tc 3.22 0 Td (20-fo)Tj 0.082 0.082 0.078 rg 0.0081 Tc 2.08 0 Td (ld )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.5732 0 0 10.6 238.45 203.29 Tm (and )Tj -0.026 Tc 10.6 0 0 10.6 256.21 203.29 Tm (73-fold )Tj -0.035 Tc 10.3728 0 0 10.6 55.18 192.25 Tm (more )Tj -0.0176 Tc 10.6 0 0 10.6 78.26 192.25 Tm (potent )Tj -0.035 Tc 10.12 0 0 10.6 107.02 192.25 Tm (than )Tj 0.165 0.169 0.165 rg 0 Tc 10.6 0 0 10.6 126.7 192.25 Tm (m)Tj 0.333 0.333 0.329 rg 0.716 0 Td (e)Tj 0.165 0.169 0.165 rg -0.0242 Tc 0.46 0 Td (thacholine )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.5732 0 0 10.6 183.73 192.25 Tm (and )Tj -0.032 Tc 10.6 0 0 10.6 201.45 192.25 Tm (58-fold )Tj -0.035 Tc 10.5732 0 0 10.6 233.65 192.25 Tm (and )Tj 0.165 0.169 0.165 rg 9.8926 0 0 10.6 252.14 192.25 Tm (112)Tj 0.333 0.333 0.329 rg -0.0276 Tc 10.6 0 0 10.6 266.28 192.25 Tm (-fo)Tj 0.165 0.169 0.165 rg -0.035 Tc 10.5676 0 0 10.6 277.83 192.25 Tm (ld )Tj 0.239 0.239 0.235 rg -0.0338 Tc 10.6 0 0 10.6 54.7 181.21 Tm (more )Tj -0.0176 Tc 2.313 0 Td (potent )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.4177 0 0 10.6 108.45 181.21 Tm (than )Tj -0.0264 Tc 10.6 0 0 10.6 129.58 181.21 Tm (histamine )Tj 0.239 0.239 0.235 rg -0.0287 Tc 3.977 0 Td (on )Tj 0 Tc 1.312 0 Td (a )Tj -0.0267 Tc 0.824 0 Td (molar )Tj 0.165 0.169 0.165 rg -0.0216 Tc 2.584 0 Td (basis )Tj 0.239 0.239 0.235 rg -0.035 Tc 9.9195 0 0 10.6 245.68 181.21 Tm (in )Tj 0.165 0.169 0.165 rg -0.0181 Tc 10.6 0 0 10.6 257.27 181.21 Tm (nonnal )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.5732 0 0 10.6 54.61 170.16 Tm (and )Tj -0.024 Tc 10.6 0 0 10.6 71.41 170.16 Tm (asthmatic )Tj -0.0227 Tc 3.845 0 Td (subjects )Tj 0.165 0.169 0.165 rg -0.0304 Tc 3.273 0 Td (respectively. )Tj -0.035 Tc 10.4176 0 0 10.6 199.61 170.16 Tm (In )Tj 0.239 0.239 0.235 rg -0.0259 Tc 10.6 0 0 10.6 210.61 170.16 Tm (addition, )Tj -0.0297 Tc 3.532 0 Td (asthmatic )Tj -0.0227 Tc -18.253 -1.041 Td (subjects )Tj -0.0266 Tc 3.499 0 Td (were )Tj 0.165 0.169 0.165 rg -0.0233 Tc 2.256 0 Td (approximately )Tj 0.239 0.239 0.235 rg -0.0194 Tc 5.891 0 Td (25-fold )Tj 0.165 0.169 0.165 rg -0.0338 Tc 3.264 0 Td (more )Tj 0.239 0.239 0.235 rg -0.0205 Tc 2.388 0 Td (sensitive )Tj -0.035 Tc 10.3833 0 0 10.6 277.89 159.13 Tm (to )Tj -0.0032 Tc 10.6 0 0 10.6 53.7 148.09 Tm (LTE)Tj 0 Tc 6.4001 0 0 6.4001 72.46 144.73 Tm (4 )Tj 0.165 0.169 0.165 rg -0.0292 Tc 10.6 0 0 10.6 80.61 148.09 Tm (than )Tj 0.239 0.239 0.235 rg -0.0266 Tc 2.039 0 Td (were )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.499 0 0 10.6 126.23 148.09 Tm (normal )Tj 0.239 0.239 0.235 rg -0.0228 Tc 10.6 0 0 10.6 158.73 148.09 Tm (subjects, )Tj -0.0224 Tc 3.728 0 Td (but )Tj 0.165 0.169 0.165 rg -0.0266 Tc 1.582 0 Td (were )Tj 0.239 0.239 0.235 rg -0.027 Tc 2.211 0 Td (only )Tj -0.0308 Tc 2.127 0 Td (7-fold )Tj -0.035 Tc 10.3728 0 0 10.6 54.7 137.52 Tm (more )Tj -0.0092 Tc 10.6 0 0 10.6 78.57 137.52 Tm (sensitive )Tj 0.0424 Tc 9.4 0 0 9.4 118.06 137.52 Tm (to )Tj 0.165 0.169 0.165 rg -0.0264 Tc 10.6 0 0 10.6 130.06 137.52 Tm (histamine )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.5732 0 0 10.6 172.21 137.52 Tm (and )Tj -0.0273 Tc 10.6 0 0 10.6 191.02 137.52 Tm (methacholine. )Tj -0.035 Tc 10.3546 0 0 10.6 63.32 126.48 Tm (We )Tj -0.0209 Tc 10.6 0 0 10.6 80.54 126.48 Tm (demonstrate )Tj -0.0266 Tc 4.979 0 Td (for )Tj -0.035 Tc 10.4562 0 0 10.6 148.77 126.48 Tm (the )Tj -0.0221 Tc 10.6 0 0 10.6 164.04 126.48 Tm (first )Tj -0.0321 Tc 1.865 0 Td (time )Tj -0.0152 Tc 1.992 0 Td (that )Tj 0.165 0.169 0.165 rg -0.0343 Tc 1.811 0 Td (there )Tj -0.0159 Tc 2.168 0 Td (is )Tj 0.239 0.239 0.235 rg 0 Tc 0.949 0 Td (a )Tj -0.0333 Tc 0.737 0 Td (posi\255)Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.2685 0 0 10.6 54.69 115.44 Tm (tiv)Tj 0.392 0.392 0.388 rg 0 Tc 10.6 0 0 10.6 64.69 115.44 Tm (e )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.271 0 0 10.6 73.34 115.44 Tm (co)Tj 0.239 0.239 0.235 rg -0.0266 Tc 10.6 0 0 10.6 83.02 115.44 Tm (rrelation )Tj 0.333 0.333 0.329 rg -0.0323 Tc 3.625 0 Td (between )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.1617 0 0 10.6 159.3 115.44 Tm (LTE)Tj 0.392 0.392 0.388 rg 0 Tc 6.8001 0 0 6.8001 177.09 112.08 Tm (4 )Tj ET BT /Suspect <>BDC 0.239 0.239 0.235 rg /T1_0 1 Tf -0.035 Tc 9.7748 0 0 10.6 185.24 115.44 Tm (PD)Tj 0.392 0.392 0.388 rg 0.0251 Tc 6.8001 0 0 6.8001 197.68 111.6 Tm (35 )Tj EMC ET BT 0.333 0.333 0.329 rg /T1_0 1 Tf -0.035 Tc 10.2207 0 0 10.6 208.7 115.44 Tm (and )Tj 0.239 0.239 0.235 rg -0.0264 Tc 10.6 0 0 10.6 227.5 115.44 Tm (histamine )Tj -0.035 Tc 10.2207 0 0 10.6 270.62 115.44 Tm (and )Tj -0.0314 Tc 10.6 0 0 10.6 54.7 104.4 Tm (methacholin)Tj 0.392 0.392 0.388 rg 0 Tc 4.656 0 Td (e )Tj ET BT /Suspect <>BDC 0.333 0.333 0.329 rg /T1_0 1 Tf 0.0053 Tc 10.6 0 0 10.6 113.7102 104.4 Tm (PD)Tj 0 Tc 6.8001 0 0 6.8001 127.12 100.57 Tm (3 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.2747 0 0 10.6 140.15 104.4 Tm (when )Tj 0.239 0.239 0.235 rg 10.3947 0 0 10.6 168.01 104.4 Tm (both )Tj 0.333 0.333 0.329 rg -0.0184 Tc 10.6 0 0 10.6 191.41 104.4 Tm (asthmatic )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.2207 0 0 10.6 236.06 104.4 Tm (and )Tj -0.0181 Tc 10.6 0 0 10.6 256.79 104.4 Tm (nonnal )Tj 0.392 0.392 0.388 rg 0 Tc -19.123 -1.042 Td (s)Tj 0.239 0.239 0.235 rg -0.035 Tc 9.947 0 0 10.6 58.56 93.36 Tm (ubj)Tj 0.392 0.392 0.388 rg 10.3941 0 0 10.6 70.93 93.36 Tm (ec)Tj 0.239 0.239 0.235 rg 9.9261 0 0 10.6 80.14 93.36 Tm (ts )Tj 0.333 0.333 0.329 rg 10.5454 0 0 10.6 90.61 93.36 Tm (are )Tj ET BT /Suspect <>BDC /C0_0 1 Tf 0 Tc 4.3201 0 0 12 107.04 93.36 Tm <0063006F006E00730069007E00650072006300640020>Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf -0.035 Tc 9.7417 0 0 10.6 155.03 93.36 Tm (wh)Tj 0.392 0.392 0.388 rg 0 Tc 10.6 0 0 10.6 166.93 93.36 Tm (e)Tj 0.239 0.239 0.235 rg 0.462 0 Td (n )Tj -0.035 Tc 10.4562 0 0 10.6 180.93 93.36 Tm (the )Tj -0.0259 Tc 10.6 0 0 10.6 197.67 93.36 Tm (linear )Tj 0 Tc 2.542 0 Td (r)Tj 0.392 0.392 0.388 rg -0.0154 Tc 0.218 0 Td (egress)Tj 0.239 0.239 0.235 rg -0.035 Tc 9.6738 0 0 10.6 253.36 93.36 Tm (ion )Tj 10.0572 0 0 10.6 269.75 93.36 Tm (was )Tj -0.0247 Tc 10.6 0 0 10.6 308.54 746.65 Tm (calculated )Tj -0.035 Tc 10.33 0 0 10.6 354.13 746.65 Tm (for )Tj 0.165 0.169 0.165 rg -0.0306 Tc 10.6 0 0 10.6 370.57 746.65 Tm (both )Tj 0.239 0.239 0.235 rg 0.0478 Tc 2.118 0 Td (of )Tj 0.165 0.169 0.165 rg -0.0256 Tc 1.32 0 Td (these )Tj 0.239 0.239 0.235 rg -0.0285 Tc 2.389 0 Td (subjects. )Tj 0.165 0.169 0.165 rg -0.0226 Tc 3.762 0 Td (Comparisons )Tj 0.239 0.239 0.235 rg 0.0478 Tc 5.48 0 Td (of )Tj -0.0195 Tc -20.958 -0.996 Td (results )Tj 0.165 0.169 0.165 rg -0.035 Tc 9.9195 0 0 10.6 337.84 736.09 Tm (in )Tj 10.4562 0 0 10.6 348.45 736.09 Tm (the )Tj -0.0213 Tc 10.6 0 0 10.6 363.75 736.09 Tm (literature )Tj 0.239 0.239 0.235 rg -0.0153 Tc 3.666 0 Td (are )Tj -0.0241 Tc 1.45 0 Td (complicated )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.5506 0 0 10.6 469.93 736.09 Tm (by )Tj -0.0217 Tc 10.6 0 0 10.6 483.26 736.09 Tm (differences )Tj -0.035 Tc 10.5807 0 0 10.6 530.79 736.09 Tm (in )Tj 10.4562 0 0 10.6 308.61 725.05 Tm (the )Tj 0.239 0.239 0.235 rg 10.4507 0 0 10.6 322.93 725.05 Tm (aerosol )Tj 0.165 0.169 0.165 rg 10.4936 0 0 10.6 353.18 725.05 Tm (delivery )Tj 0.239 0.239 0.235 rg 10.5315 0 0 10.6 387.81 725.05 Tm (technique )Tj 0.165 0.169 0.165 rg 10.2207 0 0 10.6 428.06 725.05 Tm (and )Tj 0.239 0.239 0.235 rg 10.4562 0 0 10.6 444.93 725.05 Tm (the )Tj ET BT /Suspect <>BDC 0.165 0.169 0.165 rg /T1_0 1 Tf -0.0253 Tc 10.6 0 0 10.6 458.78 725.05 Tm (details )Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf 0.0478 Tc 10.6 0 0 10.6 486.6156 725.05 Tm (of )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.4562 0 0 10.6 497.73 725.05 Tm (the )Tj 0.239 0.239 0.235 rg 10.4268 0 0 10.6 512.05 725.05 Tm (airway )Tj 0.165 0.169 0.165 rg -0.0292 Tc 10.6 0 0 10.6 308.62 714 Tm (measurements )Tj -0.035 Tc 10.3679 0 0 10.6 368.14 714 Tm (made. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0063 Tc 10.6 0 0 10.6 394.45 714 Tm (One )Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf -0.0299 Tc 10.6 0 0 10.6 413.6466 714 Tm (approach )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.3833 0 0 10.6 453.09 714 Tm (to )Tj 0.239 0.239 0.235 rg -0.0189 Tc 10.6 0 0 10.6 463.1 714 Tm (compare )Tj 0.165 0.169 0.165 rg -0.023 Tc 3.487 0 Td (data )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.0797 0 0 10.6 519.73 714 Tm (from )Tj 0.165 0.169 0.165 rg -0.0212 Tc 10.6 0 0 10.6 308.54 703.44 Tm (different )Tj 0.239 0.239 0.235 rg -0.0206 Tc 3.754 0 Td (studies )Tj 0.165 0.169 0.165 rg -0.0159 Tc 3.13 0 Td (is )Tj -0.035 Tc 10.3833 0 0 10.6 394.05 703.44 Tm (to )Tj 0.239 0.239 0.235 rg -0.026 Tc 10.6 0 0 10.6 407.41 703.44 Tm (evaluate )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.4562 0 0 10.6 446.85 703.44 Tm (the )Tj -0.0222 Tc 10.6 0 0 10.6 464.14 703.44 Tm (responsiveness )Tj 0.05 Tc 11.1292 0 0 10.6 529.81 703.44 Tm (of )Tj 0.239 0.239 0.235 rg -0.0252 Tc 10.6 0 0 10.6 308.07 692.41 Tm (groups )Tj 0.0478 Tc 2.942 0 Td (of )Tj 0.165 0.169 0.165 rg -0.009 Tc 1.141 0 Td (nonnal )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.2207 0 0 10.6 383.42 692.41 Tm (and )Tj 0.165 0.169 0.165 rg -0.024 Tc 10.6 0 0 10.6 401.17 692.41 Tm (asthmatic )Tj 0.239 0.239 0.235 rg -0.0227 Tc 3.981 0 Td (subjects )Tj -0.024 Tc 3.442 0 Td (studied )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.0482 0 0 10.6 512.65 692.41 Tm (by )Tj -0.0201 Tc 10.6 0 0 10.6 526.05 692.41 Tm (the )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.4905 0 0 10.6 308.49 681.85 Tm (same )Tj 0.165 0.169 0.165 rg -0.0241 Tc 10.6 0 0 10.6 332.55 681.85 Tm (investigators )Tj -0.035 Tc 10.5807 0 0 10.6 387.27 681.85 Tm (in )Tj -0.0334 Tc 10.6 0 0 10.6 398.37 681.85 Tm (terms )Tj 0.239 0.239 0.235 rg 0.0478 Tc 2.439 0 Td (of )Tj -0.0154 Tc 1.139 0 Td (their )Tj -0.0135 Tc 2.039 0 Td (relative )Tj -0.026 Tc 3.215 0 Td (responsive\255)Tj 0.165 0.169 0.165 rg -0.035 Tc 10.4174 0 0 10.6 308.63 670.8 Tm (ness )Tj 10.3833 0 0 10.6 332.13 670.8 Tm (to )Tj -0.0267 Tc 10.6 0 0 10.6 346.95 670.8 Tm (leukotrienes )Tj -0.035 Tc 10.5732 0 0 10.6 402.13 670.8 Tm (and )Tj 0.239 0.239 0.235 rg 9.7344 0 0 10.6 423.82 670.8 Tm (to )Tj 0.165 0.169 0.165 rg -0.0227 Tc 10.6 0 0 10.6 437.74 670.8 Tm (reference )Tj -0.0199 Tc 4.158 0 Td (agonists )Tj -0.035 Tc 10.3828 0 0 10.6 521.99 670.8 Tm ([18\) )Tj 0.239 0.239 0.235 rg -0.0238 Tc 10.6 0 0 10.6 308.51 659.76 Tm (\([nonnals/asthmatics\) )Tj 0.165 0.169 0.165 rg -0.0257 Tc 8.388 0 Td (responsiveness )Tj -0.0048 Tc 5.886 0 Td (to )Tj 0.082 0.082 0.078 rg 0 Tc 0.997 0 Td (r)Tj 0.239 0.239 0.235 rg -0.0144 Tc 0.263 0 Td (eference )Tj 0.165 0.169 0.165 rg -0.0188 Tc 3.442 0 Td (agonist )Tj -0.0301 Tc -19.018 -0.995 Td (divided )Tj -0.035 Tc 10.0482 0 0 10.6 345.13 649.21 Tm (by )Tj 0.239 0.239 0.235 rg -0.0233 Tc 10.6 0 0 10.6 362.14 649.21 Tm ([nonnals/asthmatics] )Tj -0.0222 Tc 8.491 0 Td (responsiveness )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.3833 0 0 10.6 519.81 649.21 Tm (to )Tj 0.239 0.239 0.235 rg 0 Tc 10.6 0 0 10.6 533.65 649.21 Tm (a )Tj -0.0293 Tc -21.236 -1.042 Td (leukotriene\). )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.4736 0 0 10.6 366.15 638.17 Tm (The )Tj 0.239 0.239 0.235 rg -0.0265 Tc 10.6 0 0 10.6 389.26 638.17 Tm (relative )Tj -0.0188 Tc 3.487 0 Td (responsiveness )Tj 0.165 0.169 0.165 rg 0.05 Tc 11.6856 0 0 10.6 493.81 638.17 Tm (of )Tj -0.009 Tc 10.6 0 0 10.6 509.75 638.17 Tm (nonnal )Tj -0.0213 Tc -19.026 -1.042 Td (individuals )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.33 0 0 10.6 356.05 627.12 Tm (for )Tj 0.165 0.169 0.165 rg -0.0201 Tc 10.6 0 0 10.6 370.53 627.12 Tm (the )Tj -0.0227 Tc 1.45 0 Td (reference )Tj 0.239 0.239 0.235 rg -0.0195 Tc 3.795 0 Td (agonist, )Tj 0.165 0.169 0.165 rg -0.0207 Tc 3.314 0 Td (histamine )Tj 0.0025 Tc 3.977 0 Td (or )Tj -0.035 Tc 10.542 0 0 10.6 515.02 627.12 Tm (meth\255)Tj 0.239 0.239 0.235 rg -0.0282 Tc 10.6 0 0 10.6 308.05 616.56 Tm (acholine, )Tj -0.0159 Tc 3.851 0 Td (is )Tj 0.165 0.169 0.165 rg -0.0218 Tc 1.042 0 Td (greater )Tj -0.035 Tc 10.4177 0 0 10.6 392.61 616.56 Tm (than )Tj -0.0201 Tc 10.6 0 0 10.6 414.21 616.56 Tm (the )Tj -0.02 Tc 1.586 0 Td (relative )Tj 0.239 0.239 0.235 rg -0.0222 Tc 3.26 0 Td (responsiveness )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.3833 0 0 10.6 530.85 616.56 Tm (to )Tj -0.0318 Tc 10.6 0 0 10.6 308.09 606 Tm (Ieukotrienes )Tj -0.035 Tc 9.9195 0 0 10.6 359.92 606 Tm (in )Tj -0.0343 Tc 10.6 0 0 10.6 371.01 606 Tm (three )Tj 0.239 0.239 0.235 rg 0.0478 Tc 2.122 0 Td (of )Tj 0.165 0.169 0.165 rg -0.0201 Tc 1.048 0 Td (the )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.3279 0 0 10.6 419.89 606 Tm (four )Tj -0.0261 Tc 10.6 0 0 10.6 439.22 606 Tm (published )Tj -0.0281 Tc 3.969 0 Td (studies )Tj -0.035 Tc 10.311 0 0 10.6 512.39 606 Tm ([9, )Tj ET BT /Suspect <>BDC 0.165 0.169 0.165 rg /T1_0 1 Tf 10.3916 0 0 10.6 526.2 606 Tm (10, )Tj EMC ET BT /T1_0 1 Tf 10.3916 0 0 10.6 308.7558 594.9654 Tm (19, )Tj ET BT /Suspect <>BDC 0.239 0.239 0.235 rg /T1_0 1 Tf 10.5271 0 0 10.6 324.42 594.97 Tm (20\). )Tj EMC ET BT /T1_0 1 Tf -0.0158 Tc 10.6 0 0 10.6 344.07 594.97 Tm (That )Tj ET BT /Suspect <>BDC 0.165 0.169 0.165 rg /T1_0 1 Tf -0.0197 Tc 10.6 0 0 10.6 366.6268 594.97 Tm (is, )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.5807 0 0 10.6 380.07 594.97 Tm (in )Tj 0.239 0.239 0.235 rg 0.025 Tc 9.4 0 0 9.4 392.14 594.97 Tm (three )Tj 0.0478 Tc 10.6 0 0 10.6 415.58 594.97 Tm (of )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.4562 0 0 10.6 428.61 594.97 Tm (the )Tj 0.239 0.239 0.235 rg 10.3279 0 0 10.6 444.85 594.97 Tm (four )Tj -0.021 Tc 10.6 0 0 10.6 465.45 594.97 Tm (studies, )Tj -0.024 Tc 3.219 0 Td (asthmatic )Tj -0.0227 Tc -18.072 -0.996 Td (subjects )Tj -0.0328 Tc 3.58 0 Td (failed )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.3833 0 0 10.6 374.37 584.41 Tm (to )Tj 0.239 0.239 0.235 rg -0.0138 Tc 10.6 0 0 10.6 387.73 584.41 Tm (exhibit )Tj 0.165 0.169 0.165 rg -0.0201 Tc 3.177 0 Td (the )Tj 0.239 0.239 0.235 rg -0.0114 Tc 1.664 0 Td (same )Tj -0.0234 Tc 2.495 0 Td (degree )Tj 0.0478 Tc 3.034 0 Td (of )Tj 0.165 0.169 0.165 rg -0.032 Tc 1.366 0 Td (hyper\255)Tj 0.082 0.082 0.078 rg 0 Tc -19.245 -1.042 Td (r)Tj 0.239 0.239 0.235 rg -0.0249 Tc 0.308 0 Td (esponsiveness )Tj -0.0048 Tc 5.849 0 Td (to )Tj 0 Tc 1.26 0 Td (a )Tj 0.082 0.082 0.078 rg 0.953 0 Td (l)Tj 0.239 0.239 0.235 rg -0.0185 Tc 0.225 0 Td (eukotriene )Tj 0.165 0.169 0.165 rg /T1_1 1 Tf -0.035 Tc 9.1676 0 0 9.9 447.32 573.36 Tm (than )Tj 0.239 0.239 0.235 rg /T1_0 1 Tf 10.3833 0 0 10.6 470.37 573.36 Tm (to )Tj 0.165 0.169 0.165 rg 10.4562 0 0 10.6 483.81 573.36 Tm (the )Tj -0.0227 Tc 10.6 0 0 10.6 501.1 573.36 Tm (reference )Tj 0.239 0.239 0.235 rg -0.0324 Tc -18.212 -1.041 Td (agonist. )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.4176 0 0 10.6 342.17 562.33 Tm (In )Tj 10.5569 0 0 10.6 353.73 562.33 Tm (these )Tj 0.239 0.239 0.235 rg -0.0206 Tc 10.6 0 0 10.6 376.17 562.33 Tm (studies )Tj -0.0342 Tc 2.902 0 Td (airway )Tj 0.165 0.169 0.165 rg -0.0208 Tc 2.816 0 Td (response )Tj -0.035 Tc 10.3816 0 0 10.6 475.19 562.33 Tm (was )Tj -0.0181 Tc 10.6 0 0 10.6 493.34 562.33 Tm (detennined )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.0482 0 0 10.6 308.17 551.76 Tm (by )Tj 0.165 0.169 0.165 rg -0.0294 Tc 10.6 0 0 10.6 323.02 551.76 Tm (measurement )Tj 0.239 0.239 0.235 rg 0.0478 Tc 5.426 0 Td (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0298 Tc 10.6 0 0 10.6 393.0648 551.76 Tm (FEV )Tj EMC ET BT /T1_0 1 Tf 0 Tc 6.1 0 0 6.1 413.07 548.41 Tm (1)Tj 0.57 0.549 Td (, )Tj -0.0141 Tc 10.6 0 0 10.6 422.77 551.76 Tm (and )Tj -0.035 Tc 10.4456 0 0 10.6 442.44 551.76 Tm (flow )Tj 0.165 0.169 0.165 rg -0.0297 Tc 10.6 0 0 10.6 465.58 551.76 Tm (rates )Tj 0.0156 Tc 2.21 0 Td (at )Tj ET BT /Suspect <>BDC 0.239 0.239 0.235 rg /T1_0 1 Tf -0.035 Tc 10.2891 0 0 10.6 501 551.76 Tm (30% )Tj EMC ET BT 0.165 0.169 0.165 rg /T1_0 1 Tf 10.5732 0 0 10.6 523.57 551.76 Tm (and )Tj ET BT /Suspect <>BDC 0.239 0.239 0.235 rg /T1_0 1 Tf -0.0258 Tc 10.6 0 0 10.6 307.64 540.73 Tm (40% )Tj EMC ET BT /T1_0 1 Tf 0.0478 Tc 10.6 0 0 10.6 334.458 540.73 Tm (of )Tj 0.165 0.169 0.165 rg -0.0342 Tc 1.538 0 Td (forced )Tj 0.239 0.239 0.235 rg -0.0233 Tc 3.179 0 Td (vital )Tj -0.0256 Tc 2.438 0 Td (capacity. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0184 Tc 10.6 0 0 10.6 454.556 540.73 Tm (Using )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.5139 0 0 10.6 486.57 540.73 Tm (sGaw )Tj -0.0059 Tc 10.6 0 0 10.6 517.33 540.73 Tm (as )Tj 0.165 0.169 0.165 rg 0 Tc 1.54 0 Td (a )Tj -0.0249 Tc -21.275 -0.996 Td (measurement )Tj 0.239 0.239 0.235 rg 0.0478 Tc 5.336 0 Td (of )Tj -0.0197 Tc 1.133 0 Td (large )Tj -0.0254 Tc 2.217 0 Td (airways )Tj -0.0191 Tc 3.261 0 Td (calibre )Tj -0.0328 Tc 2.928 0 Td ([21, )Tj -0.0233 Tc 1.83 0 Td (22]. )Tj -0.035 Tc 10.235 0 0 10.6 504.47 530.17 Tm (we )Tj 0.165 0.169 0.165 rg 10.5341 0 0 10.6 519.82 530.17 Tm (have )Tj -0.0233 Tc 10.6 0 0 10.6 308.06 519.12 Tm (demonstrated )Tj 0.239 0.239 0.235 rg -0.0252 Tc 5.614 0 Td (airway )Tj 0.165 0.169 0.165 rg -0.0241 Tc 3.133 0 Td (hyperresponsiveness )Tj 0.239 0.239 0.235 rg -0.0048 Tc 8.376 0 Td (to )Tj 0.165 0.169 0.165 rg 0 Tc 1.265 0 Td (L )Tj -0.035 Tc 10.2692 0 0 10.6 509.19 519.12 Tm (TE)Tj 0 Tc 6.4001 0 0 6.4001 521.26 515.76 Tm (4 )Tj -0.035 Tc 10.5807 0 0 10.6 530.79 519.12 Tm (in )Tj 0.239 0.239 0.235 rg 10.5914 0 0 10.6 308.05 508.09 Tm (asthmatic )Tj -0.0341 Tc 10.6 0 0 10.6 347.85 508.09 Tm (subjects. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.5008 0 0 10.6 384.37 508.09 Tm (Our )Tj EMC ET BT 0.165 0.169 0.165 rg /T1_0 1 Tf -0.0346 Tc 10.6 0 0 10.6 402.22 508.09 Tm (results )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.5454 0 0 10.6 429.97 508.09 Tm (are )Tj 0.165 0.169 0.165 rg 9.9195 0 0 10.6 444.88 508.09 Tm (in )Tj 0.239 0.239 0.235 rg -0.026 Tc 10.6 0 0 10.6 454.45 508.09 Tm (agreement )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.3688 0 0 10.6 498.23 508.09 Tm (with )Tj 10.251 0 0 10.6 518.38 508.09 Tm (those )Tj 0.239 0.239 0.235 rg 0.0478 Tc 10.6 0 0 10.6 308.06 497.53 Tm (of )Tj -0.035 Tc 8.176 0 0 10.6 320.01 497.53 Tm (SMITH )Tj /T1_2 1 Tf 0.0357 Tc 9.7 0 0 9.7 346.95 497.53 Tm (et )Tj -0.0142 Tc 1.141 0 Td (al. )Tj /T1_0 1 Tf -0.035 Tc 9.9567 0 0 10.6 371.76 497.53 Tm ([9] )Tj 0.165 0.169 0.165 rg 9.9195 0 0 10.6 387.28 497.53 Tm (in )Tj -0.0152 Tc 10.6 0 0 10.6 398.37 497.53 Tm (that )Tj -0.035 Tc 10.3833 0 0 10.6 417.09 497.53 Tm (th)Tj 0.333 0.333 0.329 rg 0 Tc 10.6 0 0 10.6 424.69 497.53 Tm (e )Tj 0.239 0.239 0.235 rg -0.0135 Tc 0.733 0 Td (relative )Tj 0.165 0.169 0.165 rg -0.0222 Tc 3.215 0 Td (responsiveness )Tj -0.035 Tc 10.3833 0 0 10.6 530.37 497.53 Tm (to )Tj 10.4562 0 0 10.6 308.13 486.49 Tm (the )Tj 0.082 0.082 0.078 rg 0 Tc 10.6 0 0 10.6 323.91 486.49 Tm (l)Tj 0.239 0.239 0.235 rg -0.0238 Tc 0.225 0 Td (eukotrienes )Tj 0.165 0.169 0.165 rg -0.035 Tc 9.9195 0 0 10.6 376.24 486.49 Tm (in )Tj 0.239 0.239 0.235 rg -0.024 Tc 10.6 0 0 10.6 387.25 486.49 Tm (asthmatic )Tj -0.0162 Tc 3.936 0 Td (subjects )Tj -0.035 Tc 10.3816 0 0 10.6 465.59 486.49 Tm (was )Tj 10.4737 0 0 10.6 484.26 486.49 Tm (2-)Tj 0.165 0.169 0.165 rg -0.0141 Tc 10.6 0 0 10.6 495.73 486.49 Tm (and )Tj 0.239 0.239 0.235 rg -0.0284 Tc 1.765 0 Td (3-fold )Tj -0.0218 Tc -19.469 -0.996 Td (greater )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.4177 0 0 10.6 339.33 475.93 Tm (than )Tj -0.0152 Tc 10.6 0 0 10.6 359.97 475.93 Tm (that )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.3833 0 0 10.6 378.21 475.93 Tm (to )Tj 0.165 0.169 0.165 rg -0.0207 Tc 10.6 0 0 10.6 389.26 475.93 Tm (histamine )Tj -0.0141 Tc 3.976 0 Td (and )Tj -0.0273 Tc 1.729 0 Td (methacholine, )Tj -0.0278 Tc 5.66 0 Td (respec\255)Tj 0.239 0.239 0.235 rg -19.02 -1.042 Td (tively, )Tj -0.035 Tc 10.5082 0 0 10.6 337.9 464.89 Tm (when )Tj ET BT /Suspect <>BDC 0.165 0.169 0.165 rg /T1_0 1 Tf -0.0342 Tc 10.6 0 0 10.6 364.21 464.89 Tm (airway )Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf -0.0116 Tc 10.6 0 0 10.6 395.904 464.89 Tm (calibre )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.0572 0 0 10.6 428.63 464.89 Tm (was )Tj -0.013 Tc 10.6 0 0 10.6 448.7 464.89 Tm (detennined )Tj -0.035 Tc 10.5506 0 0 10.6 498.25 464.89 Tm (by )Tj 0.239 0.239 0.235 rg 10.573 0 0 10.6 512.97 464.89 Tm (sGaw. )Tj 0.165 0.169 0.165 rg -0.0148 Tc 10.6 0 0 10.6 307.59 453.84 Tm (These )Tj 0.239 0.239 0.235 rg -0.0309 Tc 2.624 0 Td (findings )Tj -0.0153 Tc 3.397 0 Td (are )Tj -0.014 Tc 1.45 0 Td (consistent )Tj -0.035 Tc 10.3688 0 0 10.6 431.03 453.84 Tm (with )Tj 0.165 0.169 0.165 rg -0.0201 Tc 10.6 0 0 10.6 452.13 453.84 Tm (the )Tj 0.239 0.239 0.235 rg -0.023 Tc 1.488 0 Td (data )Tj 0.165 0.169 0.165 rg 0.0478 Tc 1.902 0 Td (of )Tj 0.239 0.239 0.235 rg -0.035 Tc 8.2733 0 0 10.6 500.12 453.84 Tm (DA )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.9764 0 0 10.6 511.66 453.84 Tm (vmsoN )Tj EMC ET BT /T1_2 1 Tf 0.0357 Tc 9.7 0 0 9.7 308.07 442.81 Tm (et )Tj 0.0105 Tc 1.191 0 Td (al. )Tj /T1_0 1 Tf -0.035 Tc 10.0682 0 0 10.6 335.28 442.81 Tm ([11\) )Tj 0.165 0.169 0.165 rg 10.5732 0 0 10.6 356.53 442.81 Tm (and )Tj 0.239 0.239 0.235 rg -0.0124 Tc 10.6 0 0 10.6 375.21 442.81 Tm (suggest )Tj 0.165 0.169 0.165 rg -0.0152 Tc 3.317 0 Td (that )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.5807 0 0 10.6 429.99 442.81 Tm (in )Tj 0.165 0.169 0.165 rg -0.0233 Tc 10.6 0 0 10.6 442.57 442.81 Tm (bronchial )Tj 0.239 0.239 0.235 rg -0.035 Tc 10.5338 0 0 10.6 485.65 442.81 Tm (asthma )Tj 0.165 0.169 0.165 rg -0.0343 Tc 10.6 0 0 10.6 518.85 442.81 Tm (there )Tj -0.035 Tc 10.5011 0 0 10.6 308.14 432.25 Tm (may )Tj 0.239 0.239 0.235 rg /T1_1 1 Tf 9.1853 0 0 9.9 331.5 432.25 Tm (be )Tj /T1_0 1 Tf -0.0158 Tc 10.6 0 0 10.6 347.37 432.25 Tm (site )Tj -0.0229 Tc 1.947 0 Td (selectivity )Tj -0.0266 Tc 4.486 0 Td (for )Tj 0.165 0.169 0.165 rg -0.0176 Tc 1.724 0 Td (leukotriene )Tj -0.0304 Tc 4.897 0 Td (hyperrespon\255)Tj 0.239 0.239 0.235 rg -0.0198 Tc -16.767 -1.042 Td (sivcness, )Tj -0.035 Tc 10.3825 0 0 10.6 349.33 421.21 Tm (as )Tj -0.0229 Tc 10.6 0 0 10.6 362.3 421.21 Tm (compared )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.3833 0 0 10.6 407.49 421.21 Tm (to )Tj -0.0207 Tc 10.6 0 0 10.6 420.46 421.21 Tm (histamine )Tj 0.0086 Tc 4.158 0 Td (and )Tj -0.0276 Tc 1.91 0 Td (methacholine )Tj 0.239 0.239 0.235 rg -0.0256 Tc -16.664 -1.042 Td (responsiveness, )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.5732 0 0 10.6 373.33 410.16 Tm (and )Tj -0.0152 Tc 10.6 0 0 10.6 391.17 410.16 Tm (that )Tj 0.239 0.239 0.235 rg -0.024 Tc 1.668 0 Td (asthmatic )Tj -0.0162 Tc 3.891 0 Td (subjects )Tj 0.165 0.169 0.165 rg -0.035 Tc 10.2094 0 0 10.6 485.74 410.16 Tm (may )Tj /T1_1 1 Tf 9.1853 0 0 9.9 505.74 410.16 Tm (be )Tj /T1_0 1 Tf 10.3728 0 0 10.6 518.38 410.16 Tm (more )Tj -0.0245 Tc 10.6 0 0 10.6 308.14 399.61 Tm (hyperresponsive )Tj 0.239 0.239 0.235 rg -0.035 Tc 9.7344 0 0 10.6 377.26 399.61 Tm (to )Tj 10.4562 0 0 10.6 387.81 399.61 Tm (the )Tj 0.165 0.169 0.165 rg -0.0225 Tc 10.6 0 0 10.6 403.11 399.61 Tm (leukotrienes )Tj -0.0224 Tc 9.1 0 0 9.1 455.93 399.61 Tm (in )Tj -0.035 Tc 10.0379 0 0 10.6 467.02 399.61 Tm (the )Tj -0.0197 Tc 10.6 0 0 10.6 481.83 399.61 Tm (large )Tj 0.239 0.239 0.235 rg -0.0316 Tc 2.172 0 Td (airways. )Tj 0.165 0.169 0.165 rg 0.0231 Tc 9.1 0 0 9.1 402.2 371.76 Tm (References )Tj 0.239 0.239 0.235 rg -0.035 Tc 8.9497 0 0 9.1 308.33 352.09 Tm (1. )Tj 0.165 0.169 0.165 rg -0.0043 Tc 9.1 0 0 9.1 321.56 352.09 Tm (Hargreave )Tj 0.239 0.239 0.235 rg -0.035 Tc 9.0304 0 0 9.1 363.32 352.09 Tm (FE. )Tj -0.0165 Tc 9.1 0 0 9.1 380.12 352.09 Tm (Ryan )Tj 0.165 0.169 0.165 rg -0.0075 Tc 2.474 0 Td (G, )Tj 0.239 0.239 0.235 rg 0.0152 Tc 1.373 0 Td (Thomson )Tj 0.0361 Tc 4.233 0 Td (NC )Tj /T1_2 1 Tf 0.05 Tc 8.8825 0 0 8.8 470.32 352.09 Tm (et )Tj 0.0091 Tc 8.8 0 0 8.8 480.9 352.09 Tm (a/. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 494.3024 352.09 Tm (-)Tj EMC ET BT 0.165 0.169 0.165 rg /T1_0 1 Tf -0.0018 Tc 9.1 0 0 9.1 503 352.09 Tm (Bronchial )Tj -0.0067 Tc -21.465 -1.109 Td (responsiveness )Tj -0.035 Tc 9.0854 0 0 9.1 365.26 342 Tm (to )Tj 0.239 0.239 0.235 rg 0.003 Tc 9.1 0 0 9.1 374.87 342 Tm (histamine )Tj 0.0314 Tc 4.211 0 Td (or )Tj 0.0004 Tc 1.168 0 Td (methacholine )Tj 0.333 0.333 0.329 rg 0 Tc 5.744 0 Td (i)Tj 0.165 0.169 0.165 rg 0.27 0 Td (n )Tj 0.239 0.239 0.235 rg -0.0147 Tc 0.835 0 Td (asthma: )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0149 Tc 9.1 0 0 9.1 516.9392 342 Tm (meas\255)Tj EMC ET BT /T1_0 1 Tf -0.0003 Tc 9.1 0 0 9.1 307.6756 332.4086 Tm (urement )Tj -0.0303 Tc 3.471 0 Td (and )Tj -0.0098 Tc 1.635 0 Td (clinical )Tj -0.0076 Tc 3.108 0 Td (significance. )Tj /T1_2 1 Tf 0 Tc 9.6 0 0 9.6 429.7 332.41 Tm (J )Tj -0.0175 Tc 9.5 0 0 9.5 435.98 332.41 Tm (Allergy )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0298 Tc 8.8 0 0 8.8 464.47 332.41 Tm (C/in )Tj EMC /Suspect <>BDC -0.035 Tc 9.1988 0 0 9.5 482.5 332.41 Tm (Jmnwnol, )Tj EMC ET BT /T1_0 1 Tf -0.0172 Tc 9.1 0 0 9.1 518.57 332.41 Tm (1981, )Tj -0.0325 Tc -23.134 -1.108 Td (68, )Tj 0.0209 Tc 1.582 0 Td (347-355. )Tj -0.035 Tc 8.9643 0 0 9.1 307.63 312.25 Tm (2. )Tj 0.0044 Tc 9.1 0 0 9.1 321.03 312.25 Tm (Cockcroft )Tj 0.165 0.169 0.165 rg 0.0002 Tc 4.331 0 Td (DW, )Tj -0.0047 Tc 2.321 0 Td (Killian )Tj -0.0211 Tc 3.112 0 Td (DN, )Tj 0.239 0.239 0.235 rg 0.0157 Tc 1.952 0 Td (Mellon )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.3839 0 0 10 457.87 312.25 Tm (JJA. )Tj EMC ET BT 0.165 0.169 0.165 rg /T1_0 1 Tf -0.0043 Tc 9.1 0 0 9.1 477.08 312.25 Tm (Hargreave )Tj -0.0137 Tc 4.484 0 Td (FE. )Tj 0.333 0.333 0.329 rg 0 Tc 1.733 0 Td (-)Tj 0.239 0.239 0.235 rg -0.0018 Tc -24.836 -1.055 Td (Bronchial )Tj 0.0031 Tc 4.223 0 Td (reactivity )Tj 0.0166 Tc 4.166 0 Td (to )Tj -0.0038 Tc 1.155 0 Td (inhaled )Tj -0.0046 Tc 3.277 0 Td (histamine: )Tj 0 Tc 4.527 0 Td (a )Tj 0.0028 Tc 0.799 0 Td (method )Tj -0.0303 Tc 3.368 0 Td (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0046 Tc 9.1 0 0 9.1 519.2767 302.6495 Tm (clini\255)Tj EMC ET BT /T1_0 1 Tf 0.0087 Tc 9.1 0 0 9.1 307.1193 292.5576 Tm (cal )Tj -0.0069 Tc 1.578 0 Td (survey. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0298 Tc 8.8 0 0 8.8 351.19 292.56 Tm (C/in )Tj EMC ET BT /T1_2 1 Tf -0.0146 Tc 9.5 0 0 9.5 369.74 292.56 Tm (Allergy, )Tj /T1_0 1 Tf -0.0172 Tc 9.1 0 0 9.1 402.89 292.56 Tm (1977, )Tj 0.0131 Tc 2.555 0 Td (7, )Tj 0.0259 Tc 1.113 0 Td (235-243. )Tj -0.0274 Tc -14.143 -1.107 Td (3. )Tj 0.165 0.169 0.165 rg -0.0047 Tc 1.484 0 Td (Jun)Tj 0.333 0.333 0.329 rg 0.0152 Tc 1.369 0 Td (iper )Tj 0.165 0.169 0.165 rg -0.035 Tc 9.0013 0 0 9.1 350.83 282.49 Tm (EF, )Tj 0.239 0.239 0.235 rg -0.0067 Tc 9.1 0 0 9.1 366.2 282.49 Tm (Frith )Tj ET BT /Suspect <>BDC 0.165 0.169 0.165 rg /T1_0 1 Tf -0.0179 Tc 9.1 0 0 9.1 386.3565 282.49 Tm (PA, )Tj EMC ET BT /T1_0 1 Tf 0.0023 Tc 9.1 0 0 9.1 403.1551 282.49 Tm (Hargreave )Tj 0.239 0.239 0.235 rg -0.035 Tc 9.0304 0 0 9.1 443.96 282.49 Tm (FE.)Tj 0.392 0.392 0.388 rg 0 Tc 9.1 0 0 9.1 459.25 282.49 Tm (-)Tj 0.239 0.239 0.235 rg -0.0075 Tc 0.854 0 Td (Airway )Tj -0.006 Tc 3.271 0 Td (responsive)Tj 0.392 0.392 0.388 rg 0 Tc 4.209 0 Td (\255)Tj 0.165 0.169 0.165 rg -0.0275 Tc -24.991 -1.108 Td (ness )Tj 0.239 0.239 0.235 rg 0.0166 Tc 2.056 0 Td (to )Tj 0.003 Tc 1.109 0 Td (histamine )Tj -0.0039 Tc 4.264 0 Td (and )Tj -0.0051 Tc 1.801 0 Td (methacholine: )Tj 0.165 0.169 0.165 rg -0.0019 Tc 6.067 0 Td (relationship )Tj -0.035 Tc 9.0854 0 0 9.1 492.94 272.41 Tm (to )Tj 0.239 0.239 0.235 rg -0.005 Tc 9.1 0 0 9.1 503.02 272.41 Tm (minimum )Tj -0.0028 Tc -21.468 -1.055 Td (treatment )Tj 0.165 0.169 0.165 rg -0.035 Tc 9.0854 0 0 9.1 345.58 262.81 Tm (to )Tj 0.239 0.239 0.235 rg -0.0024 Tc 9.1 0 0 9.1 356.07 262.81 Tm (control )Tj 0.0044 Tc 3.266 0 Td (symptoms )Tj 0.05 Tc 9.4598 0 0 9.1 427.11 262.81 Tm (of )Tj -0.0014 Tc 9.1 0 0 9.1 438.63 262.81 Tm (asthma. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0111 Tc 9.2 0 0 9.2 470.21 262.81 Tm (Thorax. )Tj EMC ET BT /T1_0 1 Tf -0.0172 Tc 9.1 0 0 9.1 503.21 262.81 Tm (1981, )Tj -0.0263 Tc 2.607 0 Td (36, )Tj 0.013 Tc -24.108 -1.108 Td (575-579. )Tj 0.0038 Tc -0.043 -1.108 Td (4. )Tj 0.165 0.169 0.165 rg 0.0108 Tc 1.477 0 Td (Mathe )Tj 0.239 0.239 0.235 rg -0.0265 Tc 2.956 0 Td (AA, )Tj -0.0014 Tc 2.108 0 Td (Hcdqvist )Tj ET BT /Suspect <>BDC 0.165 0.169 0.165 rg /T1_0 1 Tf -0.035 Tc 8.2578 0 0 9.1 403.16 242.65 Tm (P, )Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf 0.0011 Tc 9.1 0 0 9.1 413.24 242.65 Tm (Holgren )Tj -0.035 Tc 8.763 0 0 9.1 446.86 242.65 Tm (A, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9.1 0 0 9.1 458.71 242.65 Tm (Svanborg )Tj EMC ET BT /T1_0 1 Tf -0.0226 Tc 9.1 0 0 9.1 496.839 242.65 Tm (N. )Tj 0.333 0.333 0.329 rg 0 Tc 1.355 0 Td (-)Tj ET BT /Suspect <>BDC 0.239 0.239 0.235 rg /T1_0 1 Tf -0.0106 Tc 9.1 0 0 9.1 516.9227 242.65 Tm (Bron\255)Tj EMC ET BT /T1_0 1 Tf -0.0053 Tc 9.1 0 0 9.1 307.1131 233.0495 Tm (chial )Tj 0.0031 Tc 2.33 0 Td (reactivity )Tj 0.0253 Tc 8.4 0 0 8.4 367.18 233.05 Tm (to )Tj 0.0002 Tc 9.1 0 0 9.1 377.77 233.05 Tm (prostaglandin )Tj 0.165 0.169 0.165 rg 0 Tc 5.849 0 Td (F )Tj ET BT /Suspect <>BDC 0.239 0.239 0.235 rg /T1_0 1 Tf 6.4001 0 0 6.4001 436.28 229.69 Tm (2 )Tj EMC ET BT /T1_0 1 Tf -0.0039 Tc 9.1 0 0 9.1 442.95 233.05 Tm (and )Tj 0.165 0.169 0.165 rg 0.0181 Tc 1.855 0 Td (hi)Tj 0.333 0.333 0.329 rg 0.0062 Tc 0.778 0 Td (stami)Tj 0.165 0.169 0.165 rg 0.0098 Tc 2.176 0 Td (ne )Tj 0.239 0.239 0.235 rg 0.0304 Tc 1.365 0 Td (in )Tj 0.0022 Tc 1.169 0 Td (patients )Tj -0.0103 Tc -22.209 -1.108 Td (with )Tj -0.0102 Tc 2.101 0 Td (asthma. )Tj /T1_2 1 Tf 0.0109 Tc 9.5 0 0 9.5 357.67 222.97 Tm (Br )Tj -0.0233 Tc 1.317 0 Td (Med )Tj 0.165 0.169 0.165 rg /T1_3 1 Tf 0.0035 Tc 8.6 0 0 8.6 389.2 222.97 Tm (J, )Tj 0.239 0.239 0.235 rg /T1_0 1 Tf -0.0172 Tc 9.1 0 0 9.1 400.01 222.97 Tm (1973, )Tj -0.035 Tc 8.9497 0 0 9.1 424.01 222.97 Tm (1, )Tj 0.0183 Tc 9.1 0 0 9.1 434.09 222.97 Tm (193-196. )Tj /T1_2 1 Tf -0.035 Tc 9.629 0 0 9.7 307.1 212.89 Tm (5. )Tj 0.165 0.169 0.165 rg /T1_0 1 Tf -0.0151 Tc 9.1 0 0 9.1 321.08 212.89 Tm (Hardy )Tj 0.239 0.239 0.235 rg -0.0154 Tc 2.685 0 Td (CC, )Tj 0.003 Tc 1.852 0 Td (Robinson )Tj 0.0023 Tc 4.056 0 Td (C, )Tj 0.165 0.169 0.165 rg 0.0051 Tc 1.162 0 Td (Tattersfield )Tj 0.239 0.239 0.235 rg -0.0233 Tc 4.912 0 Td (AE, )Tj -0.0065 Tc 1.844 0 Td (Holgate )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.005 Tc 9.1 0 0 9.1 501.9243 212.89 Tm (ST. )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.4971 0 0 9.1 516.84 212.89 Tm (-The )Tj 0.0003 Tc 9.1 0 0 9.1 307.21 203.29 Tm (bronchoconstrictor )Tj 0.0137 Tc 7.742 0 Td (effect )Tj 0.05 Tc 10.0163 0 0 9.1 400.22 203.29 Tm (of )Tj -0.0038 Tc 9.1 0 0 9.1 410.81 203.29 Tm (inhaled )Tj 0.0002 Tc 3.174 0 Td (prostaglandin )Tj ET BT /Suspect <>BDC 0.165 0.169 0.165 rg /T1_0 1 Tf 0 Tc 9.1 0 0 9.1 491.4815 203.29 Tm (D)Tj /T1_1 1 Tf 5.5001 0 0 5.5001 497.72 199.93 Tm (2 )Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf 0.0304 Tc 9.1 0 0 9.1 502.97 203.29 Tm (in )Tj -0.0062 Tc 1.009 0 Td (normal )Tj -0.0039 Tc -22.532 -1.108 Td (and )Tj 0.0045 Tc 1.793 0 Td (asthmatic )Tj -0.0046 Tc 4.175 0 Td (men. )Tj /T1_3 1 Tf 0 Tc 8.3 0 0 8.3 382.44 193.21 Tm (N )Tj 0.028 Tc 1.158 0 Td (Eng/ )Tj 0 Tc 8.6 0 0 8.6 412.24 193.21 Tm (J )Tj 0.165 0.169 0.165 rg /T1_2 1 Tf -0.035 Tc 9.0611 0 0 9.5 420.57 193.21 Tm (Med, )Tj 0.239 0.239 0.235 rg /T1_0 1 Tf -0.0099 Tc 9.1 0 0 9.1 442.73 193.21 Tm (1984)Tj 0.082 0.082 0.078 rg 0 Tc 1.97 0 Td (, )Tj 0.239 0.239 0.235 rg -0.0084 Tc 0.584 0 Td (311, )Tj 0.0183 Tc 2.116 0 Td (209-213. )Tj -0.035 Tc 9.0383 0 0 9.1 307.09 183.13 Tm (6. )Tj -0.011 Tc 9.1 0 0 9.1 321.1 183.13 Tm (Anderton )Tj -0.025 Tc 3.954 0 Td (RC, )Tj 0.0295 Tc 1.841 0 Td (Cuff )Tj 0.165 0.169 0.165 rg -0.035 Tc 8.9185 0 0 9.1 393.08 183.13 Tm (MT, )Tj 0.0064 Tc 9.1 0 0 9.1 411.32 183.13 Tm (Frith )Tj ET BT /Suspect <>BDC 0.239 0.239 0.235 rg /T1_0 1 Tf 0.0033 Tc 9.1 0 0 9.1 431.0033 183.13 Tm (PA )Tj EMC ET BT 0.165 0.169 0.165 rg /T1_2 1 Tf 0.05 Tc 9.4335 0 0 9.2 444.88 183.13 Tm (eta/. )Tj 0.333 0.333 0.329 rg /T1_0 1 Tf 0 Tc 9.2 0 0 9.2 465.49 183.13 Tm (-)Tj 0.239 0.239 0.235 rg -0.0018 Tc 9.1 0 0 9.1 472.76 183.13 Tm (Bronchial )Tj ET BT /Suspect <>BDC 0.165 0.169 0.165 rg /T1_0 1 Tf -0.0055 Tc 9.1 0 0 9.1 510.707 183.13 Tm (respon)Tj 0.333 0.333 0.329 rg 0 Tc 2.679 0 Td (\255)Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf -0.0049 Tc 9.1 0 0 9.1 307.0672 173.5204 Tm (siveness )Tj -0.0318 Tc 8.4 0 0 8.4 342.7 173.52 Tm (to )Tj -0.0038 Tc 9.1 0 0 9.1 354.65 173.52 Tm (inhaled )Tj 0.333 0.333 0.329 rg 0.003 Tc 3.435 0 Td (histamine )Tj 0.239 0.239 0.235 rg -0.0039 Tc 4.475 0 Td (and )Tj -0.0025 Tc 1.951 0 Td (exercise. )Tj /T1_3 1 Tf 0 Tc 8.6 0 0 8.6 480.88 173.52 Tm (J )Tj /T1_2 1 Tf -0.009 Tc 9.5 0 0 9.5 490.22 173.52 Tm (Allergy )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0116 Tc 8.8 0 0 8.8 522.07 173.52 Tm (Clin )Tj EMC /Suspect <>BDC 0.0002 Tc 9.1 0 0 9.1 306.62 163.44 Tm (lmmunol, )Tj EMC ET BT /T1_0 1 Tf -0.0304 Tc 9.1 0 0 9.1 345.2859 163.44 Tm (1979, )Tj -0.0325 Tc 2.554 0 Td (63, )Tj 0.0284 Tc 1.582 0 Td (315-320. )Tj -0.035 Tc 9.0384 0 0 9.1 307.1 153.37 Tm (7. )Tj -0.0051 Tc 9.1 0 0 9.1 320.6 153.37 Tm (Heaton )Tj -0.035 Tc 8.8655 0 0 9.1 350.84 153.37 Tm (RW, )Tj 0.165 0.169 0.165 rg 0 Tc 9.1 0 0 9.1 371 153.37 Tm (H)Tj 0.333 0.333 0.329 rg -0.0002 Tc 0.732 0 Td (enderson )Tj 0.165 0.169 0.165 rg -0.035 Tc 8.9245 0 0 9.1 414.22 153.37 Tm (AF, )Tj 0.239 0.239 0.235 rg 0.0022 Tc 9.1 0 0 9.1 431.43 153.37 Tm (Costello )Tj -0.0132 Tc 3.749 0 Td (JF. )Tj 0.165 0.169 0.165 rg 0.05 Tc 10.3753 0 0 9.1 479.88 153.37 Tm (-Cold )Tj 0.239 0.239 0.235 rg -0.0199 Tc 9.1 0 0 9.1 509.67 153.37 Tm (air )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0297 Tc 9.1 0 0 9.1 522.6284 153.37 Tm (as )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.1 0 0 9.1 533.6667 153.37 Tm (a )Tj -0.0089 Tc -24.886 -1.056 Td (bronchial )Tj -0.0017 Tc 4.062 0 Td (provocation )Tj -0.0107 Tc 5.166 0 Td (technique: )Tj -0.0021 Tc 4.485 0 Td (reproducibility )Tj -0.0303 Tc 6.321 0 Td (and )Tj -0.0059 Tc 1.741 0 Td (compari)Tj 0.392 0.392 0.388 rg 0 Tc 3.215 0 Td (\255)Tj 0.239 0.239 0.235 rg 0.0038 Tc -25.057 -1.107 Td (son )Tj -0.0103 Tc 1.859 0 Td (with )Tj 0.003 Tc 2.163 0 Td (histamine )Tj -0.0303 Tc 4.369 0 Td (and )Tj 0.165 0.169 0.165 rg 0.003 Tc 1.854 0 Td (methacoline )Tj 0.239 0.239 0.235 rg -0.0008 Tc 5.322 0 Td (inhalation. )Tj ET BT /Suspect <>BDC 0.165 0.169 0.165 rg /T1_2 1 Tf -0.0013 Tc 8.8 0 0 8.8 490.87 133.69 Tm (Chest, )Tj EMC ET BT 0.239 0.239 0.235 rg /T1_0 1 Tf -0.0172 Tc 9.1 0 0 9.1 518.09 133.69 Tm (1984, )Tj -0.0272 Tc -23.192 -1.109 Td (86, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0131 Tc 9.1 0 0 9.1 321.439 123.5981 Tm (810-814. )Tj EMC ET BT /T1_0 1 Tf -0.0292 Tc 9.1 0 0 9.1 306.5605 113.9976 Tm (8. )Tj 0.0009 Tc 1.476 0 Td (Samuelsson )Tj 0.165 0.169 0.165 rg -0.035 Tc 8.9365 0 0 9.1 368.6 114 Tm (B. )Tj 0.392 0.392 0.388 rg 0 Tc 9.1 0 0 9.1 381.49 114 Tm (-)Tj 0.239 0.239 0.235 rg -0.0083 Tc 1.114 0 Td (Leukotrienes: )Tj -0.0039 Tc 6.016 0 Td (mediators )Tj 0.05 Tc 9.4598 0 0 9.1 487.11 114 Tm (of )Tj -0.0104 Tc 9.1 0 0 9.1 500.09 114 Tm (immediate )Tj -0.0032 Tc -21.251 -1.107 Td (hypersensitivity )Tj 0.165 0.169 0.165 rg -0.0022 Tc 6.91 0 Td (reactions )Tj -0.0039 Tc 4.211 0 Td (and )Tj 0.239 0.239 0.235 rg -0.002 Tc 2.007 0 Td (inflammation. )Tj /T1_2 1 Tf -0.0325 Tc 9.5 0 0 9.5 482.39 103.93 Tm (Science, )Tj /T1_0 1 Tf -0.0172 Tc 9.1 0 0 9.1 518.09 103.93 Tm (1983, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0144 Tc 9.1 0 0 9.1 306.6697 93.3558 Tm (220, )Tj EMC ET BT /T1_0 1 Tf 0.0205 Tc 9.1 0 0 9.1 325.7888 93.3558 Tm (568-575. )Tj ET endstream endobj 48 0 obj <>stream Hd͊zy8 >sRhF^#y QG#Oç==o/ϧ;c_mӷKv|~_oo~y>}~W=|z>{O݇q~?>Ï?o+~ߒ~;%zΏx߽w;>lp?(O?{wٸ^ PZUuTGu^5P5FjFDMԤU PjVjUmFmک]uPuNNE]E5|| _#_k55|| _#_k55|| _#_k55|| 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368.1600037 cm /Im7 Do Q q 13.4400024 0 0 14.3999939 569.2799988 314.3999939 cm /Im8 Do Q q 12.4799957 0 0 33.6000061 569.2799988 260.6399994 cm /Im9 Do Q q 41.2799988 0 0 53.7599945 538.5599976 17.7599945 cm /Im10 Do Q BT /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.035 Tc 3 Tr 7.6616 0 0 7.8001 223.19 764.41 Tm (AIRWAYS )Tj EMC /Suspect <>BDC 7.7615 0 0 7.8001 259.65 764.41 Tm (RESPONSIVENESS )Tj EMC ET BT 0.372 g /T1_0 1 Tf 0.0383 Tc 7.8001 0 0 7.8001 323.93 764.41 Tm (TO )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.035 Tc 7.6899 0 0 7.8001 336.92 764.41 Tm (LTE)Tj 0 Tc 7.8001 0 0 7.8001 349.89 760.09 Tm (4 )Tj EMC ET BT /T1_0 1 Tf 0.0091 Tc 9 0 0 9 515.9 764.41 Tm (917 )Tj 0.0216 Tc -51.947 -2.721 Td (9. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0119 Tc 9 0 0 9 66.557 739.921 Tm (Smith )Tj EMC ET BT 0.243 0.243 0.239 rg /T1_0 1 Tf -0.0317 Tc 9 0 0 9 94.988 739.921 Tm (LJ, )Tj 0.0035 Tc 1.969 0 Td (Greenberger )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.0097 Tc 9 0 0 9 164.117 739.921 Tm (PA, )Tj EMC /Suspect <>BDC 0.243 0.243 0.239 rg -0.0028 Tc 2.24 0 Td (Patterson )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.7402 0 0 9 223.64 739.92 Tm (R, )Tj -0.0058 Tc 9 0 0 9 238.04 739.92 Tm (Krell )Tj -0.0179 Tc 2.773 0 Td (RD, )Tj 0.0042 Tc -23.84 -1.066 Td (Bernstein )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0083 Tc 9 0 0 9 85.4 730.326 Tm (PR.)Tj 0.372 g 0 Tc 1.7 0 Td (-)Tj EMC ET BT 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0051 Tc 9 0 0 9 107.441 730.326 Tm (The )Tj 0.306 g 0.0082 Tc 1.811 0 Td (effect )Tj 0.05 Tc 9.4598 0 0 9 146.31 730.33 Tm (of )Tj 0.0016 Tc 9 0 0 9 156.41 730.33 Tm (inhaled )Tj -0.0051 Tc 3.146 0 Td (leukotrienc )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_1 1 Tf 0 Tc 8.9 0 0 8.9 227.41 730.33 Tm (0)Tj /T1_0 1 Tf 5.5001 0 0 5.5001 233.26 726.97 Tm (4 )Tj EMC ET BT /T1_0 1 Tf -0.0142 Tc 9 0 0 9 238.97 730.33 Tm (in )Tj -0.017 Tc 1.02 0 Td (humans. )Tj 0.306 g /T1_2 1 Tf 0.05 Tc 9.0617 0 0 9 48.14 720.73 Tm (Am )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_2 1 Tf 0.0268 Tc 9 0 0 9 63.91 720.73 Tm (Rev )Tj EMC ET BT /T1_2 1 Tf 0.0327 Tc 9 0 0 9 80.227 720.73 Tm (Respi)Tj 0.137 g 0 Tc 2.333 0 Td (r )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_2 1 Tf -0.0139 Tc 9 0 0 9 107.605 720.73 Tm (Dis, )Tj EMC ET BT /T1_0 1 Tf -0.0246 Tc 9 0 0 9 126.406 720.73 Tm (1985, )Tj -0.0084 Tc 2.613 0 Td (131, )Tj 0.306 g -0.0115 Tc 2.103 0 Td (368)Tj 0.447 0.451 0.447 rg 0.05 Tc 10.6171 0 0 9 181.8 720.73 Tm (-3)Tj 0.306 g 0.0006 Tc 9 0 0 9 190.94 720.73 Tm (72. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0026 Tc 9 0 0 9 48.65 710.65 Tm (10. )Tj EMC ET BT 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0039 Tc 9 0 0 9 66.704 710.65 Tm (Adelroth )Tj -0.035 Tc 8.8654 0 0 9 102.19 710.65 Tm (E. )Tj 0.0019 Tc 9 0 0 9 113.24 710.65 Tm (Morris )Tj 0.0046 Tc 3.093 0 Td (MM, )Tj -0.0053 Tc 2.453 0 Td (Hargrcave )Tj -0.0328 Tc 4.533 0 Td (FE, )Tj 0.0242 Tc 1.754 0 Td (O'Byrne )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.9485 0 0 9 254.84 710.65 Tm (PM)Tj 0.372 g 0 Tc 9 0 0 9 267.65 710.65 Tm (. )Tj EMC ET BT /T1_0 1 Tf 9 0 0 9 272.537 710.65 Tm (-)Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0033 Tc 9 0 0 9 48.518 701.047 Tm (N.rway )Tj EMC ET BT /T1_0 1 Tf -0.0016 Tc 9 0 0 9 78.227 701.047 Tm (responsiveness )Tj -0.028 Tc 6.346 0 Td (to )Tj -0.0008 Tc 1.063 0 Td (Jeukouienc)Tj 0.372 g 0 Tc 4.471 0 Td (s )Tj 0.306 g 0.698 0 Td (C)Tj 6.1 0 0 6.1 197.26 697.68 Tm (4 )Tj 0.243 0.243 0.239 rg 0.004 Tc 9 0 0 9 202.95 701.05 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 218.78 701.05 Tm (0)Tj 6.1 0 0 6.1 225.1 697.21 Tm (4 )Tj EMC ET BT /T1_0 1 Tf -0.0226 Tc 9 0 0 9 231.27 701.05 Tm (and )Tj 0.0253 Tc 1.714 0 Td (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0053 Tc 9 0 0 9 256.299 701.05 Tm (meth\255)Tj EMC ET BT 0.306 g /T1_0 1 Tf -0.0017 Tc 9 0 0 9 48.39 690.97 Tm (acholine )Tj 0.372 g -0.0142 Tc 3.789 0 Td (in )Tj 0.306 g 0.0071 Tc 1.076 0 Td (patients )Tj 0.243 0.243 0.239 rg 0.0317 Tc 3.518 0 Td (with )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf 0.0017 Tc 9 0 0 9 143.439 690.97 Tm (asthma )Tj EMC ET BT /T1_0 1 Tf -0.0226 Tc 9 0 0 9 172.239 690.97 Tm (and )Tj 0.372 g -0.0107 Tc 1.769 0 Td (normal )Tj 0.0054 Tc 3.138 0 Td (contro)Tj 0.243 0.243 0.239 rg -0.0237 Tc 2.614 0 Td (ls. )Tj 0.306 g /T1_2 1 Tf 0 Tc 9.3 0 0 9.3 250.64 690.97 Tm (N )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_2 1 Tf -0.003 Tc 9 0 0 9 260.71 690.97 Tm (En)Tj 0.372 g 0 Tc 1.014 0 Td (g)Tj 0.243 0.243 0.239 rg 0.589 0 Td (/ )Tj EMC ET BT /T1_2 1 Tf 9.6 0 0 9.6 47.62 681.85 Tm (J )Tj 0.306 g -0.0306 Tc 9 0 0 9 55.77 681.85 Tm (Med, )Tj 0.372 g /T1_0 1 Tf -0.0246 Tc 2.462 0 Td (1986, )Tj 0.306 g -0.0199 Tc 2.583 0 Td (315, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0237 Tc 9 0 0 9 119.958 681.85 Tm (480-484. )Tj EMC ET BT 0.372 g /T1_0 1 Tf -0.0335 Tc 9.5 0 0 9.5 48.63 671.76 Tm (11. )Tj 0.306 g -0.004 Tc 9 0 0 9 66.68 671.76 Tm (Davidson )Tj 0.243 0.243 0.239 rg -0.035 Tc 9.2179 0 0 9.5 103.66 671.76 Tm (AB, )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 7.7024 0 0 8.6 121.28 671.76 Tm (Le.e )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.1392 0 0 9 137.2 671.76 Tm (TH)Tj 0.372 g 0 Tc 9 0 0 9 150.1 671.76 Tm (, )Tj 0.306 g 0.0026 Tc 0.531 0 Td (Scanlon )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.3838 0 0 9.5 187.16 671.76 Tm (PD )Tj EMC /Suspect <>BDC /T1_2 1 Tf 0.05 Tc 7.2842 0 0 7.2 201.06 671.76 Tm (eJ )Tj EMC ET BT /T1_3 1 Tf -0.035 Tc 7.3504 0 0 8.3 210.63 671.76 Tm (aJ. )Tj 0.243 0.243 0.239 rg /T1_1 1 Tf 0 Tc 8.3 0 0 8.3 222.65 671.76 Tm (-)Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0048 Tc 9 0 0 9 230.36 671.76 Tm (Bronchocon)Tj 0.372 g 0 Tc 4.9 0 Td (\255)Tj EMC ET BT /T1_0 1 Tf 9 0 0 9 47.867 661.68 Tm (s)Tj 0.243 0.243 0.239 rg -0.021 Tc 0.439 0 Td (tr)Tj 0.372 g -0.0001 Tc 0.634 0 Td (ictor )Tj 0.306 g 0.0042 Tc 2.397 0 Td (effects )Tj 0.05 Tc 9.4598 0 0 9 108.39 661.68 Tm (of )Tj 0.243 0.243 0.239 rg 0.0056 Tc 9 0 0 9 121.36 661.68 Tm (leukotriene )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0021 Tc 9 0 0 9 167.953 661.68 Tm (Ei. )Tj EMC ET BT 0.306 g /T1_1 1 Tf 0.0259 Tc 8.8 0 0 8.8 181.27 661.68 Tm (in )Tj 0.372 g /T1_0 1 Tf 0.022 Tc 9 0 0 9 193.43 661.68 Tm (nonnal )Tj 0.306 g -0.0226 Tc 3.458 0 Td (and )Tj -0.0035 Tc 2.027 0 Td (asthmatic )Tj 0.372 g 0.003 Tc -21.658 -1.066 Td (subjects. )Tj 0.306 g /T1_2 1 Tf 0.05 Tc 9.4102 0 0 9 82.22 652.09 Tm (Am )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 9.0393 0 0 9 97.51 652.09 Tm (Rev )Tj EMC /Suspect <>BDC 0.243 0.243 0.239 rg 0.0123 Tc 9 0 0 9 114.79 652.09 Tm (Respir )Tj EMC ET BT /T1_2 1 Tf 0.0242 Tc 9 0 0 9 141.691 652.09 Tm (Dis)Tj 0.372 g 0 Tc 1.433 0 Td (, )Tj 0.306 g /T1_0 1 Tf -0.021 Tc 0.656 0 Td (198)Tj 0.525 g 0 Tc 1.41 0 Td (-)Tj 0.372 g 0.171 0 Td (/)Tj 0.243 0.243 0.239 rg 0.358 0 Td [(, )-228(1)]TJ 0.372 g 0.0068 Tc 1.071 0 Td (35, )Tj 0.0267 Tc 1.6 0 Td (333-337. )Tj 0.306 g -0.0293 Tc -17.037 -1.121 Td (12. )Tj 0.0102 Tc 1.949 0 Td (Eiser )Tj -0.035 Tc 9.38 0 0 9.5 87.88 642 Tm (NM, )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf 8.8339 0 0 9.5 108.44 642 Tm (Mill.s )Tj EMC ET BT 0.306 g /T1_2 1 Tf 9.1109 0 0 9.5 131.61 642 Tm (I, )Tj 0.243 0.243 0.239 rg /T1_0 1 Tf 0 Tc 9 0 0 9 141.08 642 Tm (M)Tj 0.372 g -0.0005 Tc 0.901 0 Td (cRae )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.035 Tc 8.8788 0 0 9 171.32 642 Tm (KO, )Tj EMC ET BT /T1_0 1 Tf -0.0063 Tc 9 0 0 9 189.92 642 Tm (Snashall )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf -0.035 Tc 8.9928 0 0 9 224.12 642 Tm (PO)Tj 0.372 g 0 Tc 9 0 0 9 235.06 642 Tm (, )Tj EMC ET BT 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0197 Tc 9 0 0 9 240.874 642 Tm (Gu)Tj 0.372 g 0 Tc 1.284 0 Td (z )Tj 0.243 0.243 0.239 rg 0.857 0 Td (A)Tj 0.372 g 0.05 Tc 17.0733 0 0 9 266.52 642 Tm (.\255)Tj 0.243 0.243 0.239 rg -0.035 Tc 8.5638 0 0 9 47.96 631.92 Tm (Hi)Tj 0.372 g 0.0199 Tc 9 0 0 9 56.51 631.92 Tm (stamine )Tj 0.243 0.243 0.239 rg -0.0043 Tc 3.48 0 Td (receptors )Tj 0.0391 Tc 3.993 0 Td (in )Tj 0.306 g 0.0107 Tc 1.073 0 Td (normal )Tj 0.243 0.243 0.239 rg 0.001 Tc 3.2 0 Td (human )Tj 0.372 g -0.0057 Tc 3.042 0 Td (bronchi. )Tj 0.243 0.243 0.239 rg /T1_2 1 Tf 0.0164 Tc 3.606 0 Td (Clin )Tj 0.306 g /T1_3 1 Tf -0.0084 Tc 8 0 0 8 240.32 631.92 Tm (Sci, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0113 Tc 9 0 0 9 256.97 631.92 Tm (1980, )Tj EMC ET BT /T1_0 1 Tf 0.0054 Tc 9 0 0 9 47.396 622.803 Tm (58, )Tj 0.0138 Tc 1.653 0 Td (537)Tj 0.447 0.451 0.447 rg 0 Tc 1.496 0 Td (-)Tj 0.306 g -0.003 Tc 0.531 0 Td (544. )Tj -0.0293 Tc -3.594 -1.173 Td (13. )Tj 0.243 0.243 0.239 rg 0.05 Tc 8.7219 0 0 8.6 65.74 612.24 Tm (Arm )Tj -0.035 Tc 9.4552 0 0 9.9 86.83 612.24 Tm (JP, )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf 0.0218 Tc 9 0 0 9 102.08 612.24 Tm (Spur )Tj EMC ET BT 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0146 Tc 9 0 0 9 123.32 612.24 Tm (BW, )Tj ET BT /Suspect <>BDC 0.306 g /T1_1 1 Tf -0.035 Tc 7.4368 0 0 8.6 145.28 612.24 Tm (Le.e )Tj EMC ET BT 0.243 0.243 0.239 rg /T1_0 1 Tf -0.0094 Tc 9 0 0 9 163.12 612.24 Tm (TH. )Tj 0.372 g 0 Tc 2.131 0 Td (-)Tj 0.306 g 0.0317 Tc 0.962 0 Td (The )Tj -0.0047 Tc 2.078 0 Td (effects )Tj 0.243 0.243 0.239 rg 0.05 Tc 9.4598 0 0 9 237.99 612.24 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.015 Tc 8.6 0 0 8.6 250.49 612.24 Tm (inhaled )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9 0 0 9 47.44 602.65 Tm (l)Tj 0.372 g 0.0368 Tc 0.264 0 Td (eu)Tj 0.243 0.243 0.239 rg 0 Tc 0.969 0 Td (k)Tj 0.372 g 0.0181 Tc 0.472 0 Td (otrien)Tj 0.243 0.243 0.239 rg 0 Tc 2.399 0 Td (e )Tj ET BT /Suspect <>BDC 0.306 g /T1_1 1 Tf 8.8 0 0 8.8 92.44 602.65 Tm (E)Tj /T1_0 1 Tf 6.4001 0 0 6.4001 97.42 599.29 Tm (4 )Tj EMC ET BT 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0337 Tc 9 0 0 9 104.55 602.65 Tm (on )Tj 0.137 g 0.035 Tc 8.3 0 0 8.3 118.06 602.65 Tm (th)Tj 0.306 g 0 Tc 0.859 0 Td (e )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf -0.0081 Tc 9 0 0 9 133.35 602.65 Tm (airway )Tj EMC ET BT /T1_0 1 Tf -0.0103 Tc 9 0 0 9 161.754 602.65 Tm (respon)Tj 0.372 g 0 Tc 2.653 0 Td (s)Tj 0.243 0.243 0.239 rg -0.0075 Tc 0.433 0 Td (iveness )Tj 0.05 Tc 8.1489 0 0 7.6 219.82 602.65 Tm (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0049 Tc 9 0 0 9 230.87 602.65 Tm (histamine )Tj EMC ET BT 0.306 g /T1_0 1 Tf -0.0142 Tc 9 0 0 9 269.687 602.65 Tm (in )Tj 0.0031 Tc -24.696 -1.067 Td (asthmatic )Tj 0.243 0.243 0.239 rg -0.0226 Tc 4.373 0 Td (and )Tj -0.0107 Tc 1.876 0 Td (normal )Tj -0.0037 Tc 3.347 0 Td (subjects. )Tj /T1_2 1 Tf 0 Tc 3.919 0 Td (J )Tj 0.0087 Tc 0.911 0 Td (Allergy )Tj 0.306 g -0.0013 Tc 3.431 0 Td (Clin )Tj 0.243 0.243 0.239 rg 0.0061 Tc 2.142 0 Td (lmmunol, )Tj 0.306 g /T1_1 1 Tf 0.05 Tc 8.5375 0 0 8.5 265.77 593.05 Tm (\(In )Tj 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0065 Tc 9 0 0 9 47.53 583.44 Tm (pre)Tj 0.372 g -0.0008 Tc 1.264 0 Td (ss\). )Tj 0.306 g -0.0026 Tc -1.247 -1.172 Td (14. )Tj 0.243 0.243 0.239 rg -0.0014 Tc 2.002 0 Td (Lew)Tj 0.372 g -0.0099 Tc 1.758 0 Td (is )Tj 0.243 0.243 0.239 rg -0.0179 Tc 0.963 0 Td (RA, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0025 Tc 9 0 0 9 107.47 572.892 Tm (Drazen )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.27 0 0 9.9 135.79 572.89 Tm (JM, )Tj 8.9402 0 0 9 152.62 572.89 Tm (Au)Tj 0.372 g -0.0124 Tc 9 0 0 9 163.55 572.89 Tm (sten )Tj 0.243 0.243 0.239 rg -0.035 Tc 8.9021 0 0 9 180.92 572.89 Tm (KF. )Tj 0.306 g 0.0053 Tc 9 0 0 9 196.71 572.89 Tm (Clarke )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf -0.0092 Tc 9 0 0 9 223.107 572.89 Tm (OA, )Tj EMC ET BT /T1_0 1 Tf -0.0051 Tc 9 0 0 9 240.864 572.89 Tm (Corey )Tj -0.0314 Tc 2.724 0 Td (EJ. )Tj 0.447 0.451 0.447 rg 0 Tc -24.272 -1.067 Td (-)Tj 0.243 0.243 0.239 rg 0.911 0 Td (I)Tj 0.372 g -0.0037 Tc 0.318 0 Td (denti)Tj 0.243 0.243 0.239 rg -0.035 Tc 8.0782 0 0 9 76.23 563.29 Tm (fi)Tj 0.372 g 0 Tc 9 0 0 9 81.51 563.29 Tm (catio)Tj 0.243 0.243 0.239 rg 1.982 0 Td (n )Tj 0.372 g 0.791 0 Td (o)Tj 0.243 0.243 0.239 rg 0.532 0 Td (f )Tj 0.0045 Tc 0.702 0 Td (the )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf 0.0041 Tc 9 0 0 9 130.947 563.29 Tm (C\(6\)-S )Tj EMC ET BT /T1_0 1 Tf 0.0038 Tc 9 0 0 9 158.784 563.29 Tm (conjugate )Tj 0.05 Tc 9.4598 0 0 9 197.19 563.29 Tm (of )Tj 0.372 g 0.0136 Tc 9 0 0 9 207.76 563.29 Tm (leukouie)Tj 0.243 0.243 0.239 rg 0.0203 Tc 3.528 0 Td (ne )Tj 0.306 g 0 Tc 1.332 0 Td (A )Tj -0.0039 Tc 1.014 0 Td (with )Tj 0.447 0.451 0.447 rg 0.0078 Tc -23.742 -1.12 Td (cysteine )Tj -0.0209 Tc 3.787 0 Td (as )Tj 0.372 g 0 Tc 1.333 0 Td (a )Tj 0.306 g -0.0033 Tc 0.916 0 Td (naturally )Tj 0.372 g 0.0039 Tc 3.991 0 Td (occurring )Tj 0.0013 Tc 4.316 0 Td (slow )Tj 0.306 g -0.0099 Tc 2.36 0 Td (reacting )Tj 0.372 g 0.0024 Tc 3.613 0 Td (subs)Tj 0.243 0.243 0.239 rg -0.0059 Tc 1.826 0 Td (tance )Tj 0.306 g 0.05 Tc 9.4598 0 0 9 268.71 553.21 Tm (of )Tj 0.372 g -0.0014 Tc 9 0 0 9 47.43 543.12 Tm (anaphylaxis )Tj ET BT /Suspect <>BDC 0.447 0.451 0.447 rg /T1_0 1 Tf -0.035 Tc 8.6218 0 0 9 94.46 543.12 Tm (\(S)Tj 0.306 g 8.5085 0 0 9 102.68 543.12 Tm (RS)Tj 0.447 0.451 0.447 rg 0 Tc 9 0 0 9 113.66 543.12 Tm (-)Tj 0.306 g -0.035 Tc 8.9816 0 0 9 116.62 543.12 Tm (A\). )Tj EMC ET BT /T1_0 1 Tf 0.0419 Tc 9 0 0 9 131.44 543.12 Tm (lmponan)Tj 0.447 0.451 0.447 rg 0.0407 Tc 3.732 0 Td (ce )Tj 0.372 g 0.05 Tc 9.4598 0 0 9 177.03 543.12 Tm (of )Tj 0.306 g 0.0045 Tc 9 0 0 9 188.62 543.12 Tm (the )Tj 0.243 0.243 0.239 rg -0.035 Tc 8.0574 0 0 9 204.2 543.12 Tm (11)Tj 0.372 g -0.0104 Tc 9 0 0 9 212.54 543.12 Tm (-cis)Tj 0.243 0.243 0.239 rg -0.0036 Tc 1.44 0 Td (-geometry )Tj 0.306 g -0.0059 Tc 4.533 0 Td (for )Tj 0.372 g 0.0017 Tc -24.361 -1.066 Td (biological )Tj 0.0025 Tc 4.469 0 Td (activity. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0048 Tc 9 0 0 9 121.028 533.526 Tm (Biochem )Tj EMC ET BT /T1_2 1 Tf -0.007 Tc 9 0 0 9 156.551 533.526 Tm (Biop)Tj 0.243 0.243 0.239 rg 0 Tc 1.907 0 Td (h)Tj 0.372 g 0.05 Tc 9.0212 0 0 9 177.82 533.53 Tm (ys )Tj 0.306 g 9.0446 0 0 9 189.19 533.53 Tm (Res )Tj ET BT /Suspect <>BDC 0.372 g /T1_2 1 Tf 0 Tc 9 0 0 9 206.7 533.53 Tm (C)Tj 0.243 0.243 0.239 rg -0.0025 Tc 0.656 0 Td (mmun, )Tj EMC /Suspect <>BDC /T1_0 1 Tf -0.0219 Tc 3.17 0 Td (19)Tj 0.372 g 0.0059 Tc 0.923 0 Td (80, )Tj EMC ET BT 0.306 g /T1_0 1 Tf 0.0008 Tc 9 0 0 9 264.858 533.53 Tm (96, )Tj 0.372 g -0.0205 Tc -24.208 -1.121 Td (271)Tj 0.525 g 0 Tc 1.434 0 Td (-)Tj 0.372 g 0.0096 Tc 0.539 0 Td (277. )Tj -0.0026 Tc -1.949 -1.12 Td (15. )Tj 0.306 g -0.016 Tc 1.944 0 Td (Chowiencyz.k )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0248 Tc 9 0 0 9 117.546 513.361 Tm (PI, )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9 0 0 9 131.469 513.361 Tm (R)Tj 0.372 g 0.0124 Tc 0.633 0 Td (ees )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf -0.0018 Tc 9 0 0 9 152.583 513.361 Tm (PI, )Tj EMC /Suspect <>BDC -0.0034 Tc 1.547 0 Td (Payn)Tj 0.372 g 0 Tc 1.967 0 Td (e )Tj EMC ET BT 0.243 0.243 0.239 rg /T1_0 1 Tf 9.5 0 0 9.5 191.47 513.36 Tm (J)Tj 0.372 g 0.394 0 Td (, )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.035 Tc 8.9904 0 0 9 200.07 513.36 Tm (Clarlc )Tj EMC ET BT /T1_0 1 Tf 0.0063 Tc 9 0 0 9 222.64 513.36 Tm (TJH.)Tj 0.137 g 0 Tc 2.344 0 Td (-)Tj 0.243 0.243 0.239 rg 0.862 0 Td (A )Tj -0.0042 Tc 1.068 0 Td (new )Tj 0.306 g 0.0202 Tc -23.788 -1.067 Td (method )Tj 0.372 g -0.0059 Tc 3.884 0 Td (for )Tj 0.306 g 0.0204 Tc 1.921 0 Td (computer-assisted )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf 0 Tc 9 0 0 9 174.148 503.757 Tm (d)Tj 0.372 g 0.531 0 Td (e)Tj 0.243 0.243 0.239 rg 0.0098 Tc 0.436 0 Td (terminati)Tj 0.372 g 0.0337 Tc 3.726 0 Td (on )Tj EMC ET BT 0.306 g /T1_0 1 Tf 0.05 Tc 9.4598 0 0 9 232.23 503.76 Tm (of )Tj -0.0004 Tc 9 0 0 9 247.59 503.76 Tm (airways )Tj 0.0027 Tc -22.338 -1.067 Td (resistance. )Tj /T1_2 1 Tf 0 Tc 4.546 0 Td (J )Tj 0.243 0.243 0.239 rg 0.0481 Tc 0.804 0 Td (Appl )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0004 Tc 9 0 0 9 115.749 494.157 Tm (Physiol, )Tj EMC ET BT 0.306 g /T1_0 1 Tf 0.002 Tc 9 0 0 9 148.491 494.157 Tm (1981, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0212 Tc 9 0 0 9 172.197 494.157 Tm (50, )Tj EMC /Suspect <>BDC 0.0174 Tc 1.654 0 Td (672-678. )Tj EMC ET BT /T1_0 1 Tf -0.0293 Tc 9 0 0 9 47.205 484.086 Tm (16. )Tj 0.243 0.243 0.239 rg -0.0072 Tc 1.95 0 Td (Krillis )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9 0 0 9 90.558 484.086 Tm (S)Tj 0.372 g 0.589 0 Td (, )Tj EMC ET BT 0.243 0.243 0.239 rg /T1_0 1 Tf -0.0072 Tc 9 0 0 9 101.232 484.086 Tm (Lewis )Tj -0.0179 Tc 2.774 0 Td (RA, )Tj 0.306 g -0.0051 Tc 1.968 0 Td (Corey )Tj 0.05 Tc 9.3047 0 0 9 169.39 484.09 Tm (EI)Tj 0.137 g 0 Tc 9 0 0 9 177.94 484.09 Tm (, )Tj 0.306 g 0.0003 Tc 0.6 0 Td (Austen )Tj 0.243 0.243 0.239 rg -0.0163 Tc 3.144 0 Td (KF.)Tj 0.372 g 0 Tc 1.807 0 Td (-)Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0091 Tc 9 0 0 9 235.639 484.09 Tm (Bioconver)Tj 0.372 g 0 Tc 4.207 0 Td (\255)Tj EMC ET BT 0.306 g /T1_0 1 Tf 0.022 Tc 9 0 0 9 46.432 474.001 Tm (sion )Tj 0.05 Tc 9.4598 0 0 9 63.75 474 Tm (of )Tj -0.035 Tc 10.271 0 0 13.7 73.82 474 Tm (c6 )Tj 0.0012 Tc 9 0 0 9 85.31 474 Tm (sulfidopeptide )Tj 0.243 0.243 0.239 rg -0.0012 Tc 5.979 0 Td (leukotrienes )Tj 0.306 g -0.0304 Tc 5.183 0 Td (by )Tj 0.243 0.243 0.239 rg 0.0045 Tc 1.223 0 Td (the )Tj -0.0017 Tc 1.441 0 Td (responding )Tj 0.0037 Tc 4.686 0 Td (guinea )Tj 0.0327 Tc -22.87 -1.066 Td (pig )Tj -0.035 Tc 8.5911 0 0 9 61.37 464.41 Tm (il)Tj 0.372 g 0 Tc 9 0 0 9 66.14 464.41 Tm (e)Tj 0.243 0.243 0.239 rg -0.035 Tc 8.8932 0 0 9 70.08 464.41 Tm (um )Tj 0 Tc 9 0 0 9 84.4 464.41 Tm (d)Tj 0.372 g -0.0116 Tc 0.531 0 Td (ete)Tj 0.243 0.243 0.239 rg -0.0104 Tc 1.183 0 Td (rmines )Tj 0.0045 Tc 3.039 0 Td (the )Tj -0.0039 Tc 1.547 0 Td (time )Tj 0.372 g -0.0163 Tc 2.126 0 Td (co)Tj 0.243 0.243 0.239 rg 0.0209 Tc 0.917 0 Td (ur)Tj 0.372 g -0.0067 Tc 0.839 0 Td (se )Tj 0.306 g 0.05 Tc 9.4598 0 0 9 186.15 464.41 Tm (of )Tj 0.243 0.243 0.239 rg -0.035 Tc 8.9631 0 0 9 197.21 464.41 Tm (its )Tj 0.372 g -0.0163 Tc 9 0 0 9 208.23 464.41 Tm (co)Tj 0.243 0.243 0.239 rg -0.0011 Tc 0.916 0 Td (ntraction. )Tj /T1_2 1 Tf 0 Tc 4.066 0 Td (J )Tj -0.0013 Tc 0.822 0 Td (Clin )Tj ET BT /Suspect <>BDC 0.306 g /T1_2 1 Tf -0.0146 Tc 9 0 0 9 46.653 454.807 Tm (Inve)Tj 0.447 0.451 0.447 rg 0 Tc 1.7 0 Td (s)Tj 0.306 g -0.035 Tc 8.8911 0 0 9 65.66 454.81 Tm (t, )Tj EMC ET BT /T1_0 1 Tf -0.0246 Tc 9 0 0 9 74.57 454.81 Tm (1983, )Tj 0.372 g 0.0006 Tc 2.53 0 Td (71, )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf 0.0174 Tc 9 0 0 9 112.217 454.81 Tm (909-915. )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.5945 0 0 9 47.22 444.72 Tm (17)Tj 0.525 g 0 Tc 9 0 0 9 55.49 444.72 Tm (. )Tj ET BT /Suspect <>BDC 0.372 g /T1_0 1 Tf 0.0007 Tc 9 0 0 9 64.157 444.72 Tm (Sautebin )Tj EMC /Suspect <>BDC 0.306 g -0.035 Tc 8.8589 0 0 9 98.83 444.72 Tm (L, )Tj EMC /Suspect <>BDC 0.243 0.243 0.239 rg 0 Tc 9 0 0 9 109.42 444.72 Tm (V)Tj 0.372 g -0.0043 Tc 0.688 0 Td (igano )Tj EMC ET BT 0.306 g /T1_0 1 Tf 0.0098 Tc 9 0 0 9 137.68 444.72 Tm (T, )Tj 0.372 g -0.0063 Tc 1.172 0 Td (Grassi )Tj 0 Tc 2.938 0 Td (E )Tj /T1_2 1 Tf -0.0132 Tc 0.85 0 Td (et )Tj 0.05 Tc 10.8715 0 0 9 190.97 444.72 Tm (al.-)Tj 0.243 0.243 0.239 rg /T1_0 1 Tf -0.0014 Tc 9 0 0 9 209.72 444.72 Tm (Release )Tj 0.306 g 0.05 Tc 9.4598 0 0 9 239.91 444.72 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.002 Tc 9 0 0 9 250 444.72 Tm (leukot\255)Tj EMC ET BT 0.372 g /T1_0 1 Tf -0.0076 Tc 9 0 0 9 46.546 434.649 Tm (ricnes )Tj -0.0089 Tc 2.873 0 Td (induced )Tj -0.0304 Tc 3.636 0 Td (by )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.0179 Tc 9 0 0 9 118.258 434.649 Tm (!he )Tj EMC ET BT 0.372 g /T1_0 1 Tf -0.0207 Tc 9 0 0 9 133.351 434.649 Tm (Ca)Tj 0 Tc 6.2 0 0 6.2 142.83 438 Tm (1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 6.6221 0 0 6.2 145.78 434.65 Tm (.. )Tj EMC ET BT /T1_0 1 Tf 0.0021 Tc 9 0 0 9 154.01 434.65 Tm (ionophore )Tj -0.0124 Tc 4.539 0 Td (A2318)Tj 0.243 0.243 0.239 rg -0.0321 Tc 2.658 0 Td (7, )Tj 0.306 g -0.0141 Tc 1.227 0 Td (from )Tj 0.001 Tc 2.41 0 Td (human )Tj 0.447 0.451 0.447 rg -0.0184 Tc -22.781 -1.121 Td (lung )Tj ET BT /Suspect <>BDC 0.372 g /T1_0 1 Tf 0.0037 Tc 9 0 0 9 65.297 424.561 Tm (parenchyma )Tj EMC ET BT /T1_0 1 Tf -0.0142 Tc 9 0 0 9 113.213 424.561 Tm (in )Tj 0.0004 Tc 1.126 0 Td (vitro. )Tj /T1_3 1 Tf 0 Tc 8.6 0 0 8.6 145.36 424.56 Tm (J )Tj ET BT /Suspect <>BDC 0.306 g /T1_2 1 Tf -0.0063 Tc 9 0 0 9 153.67 424.56 Tm (Pharma)Tj 0.525 g 0.0305 Tc (co)Tj 0.243 0.243 0.239 rg 0 Tc 4.141 0 Td (l )Tj EMC /Suspect <>BDC 0.306 g -0.035 Tc 8.9842 0 0 9.6 196.87 424.56 Tm (Exp )Tj EMC /Suspect <>BDC -0.0131 Tc 9 0 0 9 213.42 424.56 Tm (Tiler, )Tj EMC ET BT 0.243 0.243 0.239 rg /T1_0 1 Tf -0.0206 Tc 9 0 0 9 236.811 424.56 Tm (1985)Tj 0.372 g 0 Tc 1.939 0 Td (, )Tj 0.243 0.243 0.239 rg 0.0096 Tc 0.597 0 Td (234, )Tj 0.372 g 0 Tc -23.733 -1.066 Td (2)Tj 0.243 0.243 0.239 rg -0.0219 Tc 0.558 0 Td (17)Tj 0.447 0.451 0.447 rg 0.05 Tc 11.1758 0 0 9 59.39 414.97 Tm (-2)Tj 0.306 g -0.0022 Tc 9 0 0 9 68.59 414.97 Tm (21. )Tj -0.0026 Tc -2.482 -1.173 Td (18. )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0025 Tc 9 0 0 9 64.279 404.413 Tm (Drazen )Tj EMC ET BT /T1_0 1 Tf 0.0215 Tc 9 0 0 9 96.418 404.413 Tm (IA, )Tj -0.0104 Tc 2.138 0 Td (Austen )Tj ET BT /Suspect <>BDC 0.306 g /T1_3 1 Tf -0.035 Tc 8.6805 0 0 9.4 147.25 404.41 Tm (KP. )Tj EMC ET BT 0.447 0.451 0.447 rg /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 167.44 404.41 Tm (-)Tj 0.306 g /T1_0 1 Tf -0.0027 Tc 9 0 0 9 178.51 404.41 Tm (Leukotrienes )Tj -0.0226 Tc 5.916 0 Td (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0026 Tc 9 0 0 9 250.951 404.41 Tm (airway )Tj EMC ET BT /T1_0 1 Tf 0.0027 Tc 9 0 0 9 45.589 394.33 Tm (responses. )Tj /T1_3 1 Tf 0.05 Tc 8.4151 0 0 8 85.98 394.33 Tm (Am )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 9.0393 0 0 9 101.35 394.33 Tm (Rev )Tj EMC /Suspect <>BDC 0.243 0.243 0.239 rg 0.0123 Tc 9 0 0 9 118.63 394.33 Tm (Respir )Tj EMC ET BT 0.306 g /T1_2 1 Tf 0.0039 Tc 9 0 0 9 145.531 394.33 Tm (Dis, )Tj /T1_0 1 Tf -0.0246 Tc 2.142 0 Td (1987, )Tj -0.0262 Tc 2.667 0 Td (136, )Tj 0.372 g 0.025 Tc 1.997 0 Td (985-998. )Tj 0.306 g -0.0293 Tc -17.837 -1.068 Td (19. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0022 Tc 9 0 0 9 63.748 384.718 Tm (Griffin )Tj EMC ET BT /T1_0 1 Tf 0.0449 Tc 9 0 0 9 91.639 384.718 Tm (M, )Tj 0.243 0.243 0.239 rg -0.0086 Tc 1.601 0 Td (Weiss )Tj -0.035 Tc 9.2563 0 0 9.5 130.99 384.72 Tm (JW, )Tj 0.0078 Tc 9 0 0 9 148.75 384.72 Tm (Lei)Tj 0.372 g -0.0222 Tc 1.39 0 Td (tch )Tj 0.306 g -0.035 Tc 8.8941 0 0 9 175.66 384.72 Tm (AG )Tj /T1_2 1 Tf 0.05 Tc 9.6817 0 0 9 191.91 384.72 Tm (eta/.)Tj 0.447 0.451 0.447 rg 0 Tc 9 0 0 9 213.53 384.72 Tm (-)Tj 0.243 0.243 0.239 rg /T1_0 1 Tf 0.962 0 Td (E)Tj 0.372 g 0.0081 Tc 0.581 0 Td (ff)Tj 0.243 0.243 0.239 rg 0.0048 Tc 0.64 0 Td (ects )Tj 0.306 g 0.05 Tc 9.4598 0 0 9 250.47 384.72 Tm (of )Tj -0.0148 Tc 9 0 0 9 261.52 384.72 Tm (leu-)Tj 0.243 0.243 0.239 rg -0.0027 Tc 4.167 39.361 Td (kotriene )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9.5 0 0 9.5 331.1 738.97 Tm (0 )Tj EMC ET BT 0.372 g /T1_0 1 Tf -0.0196 Tc 9 0 0 9 339.75 738.97 Tm (on )Tj 0.243 0.243 0.239 rg 0.0045 Tc 1.288 0 Td (the )Tj -0.0093 Tc 1.486 0 Td (airways )Tj 0.306 g -0.0142 Tc 3.362 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0135 Tc 9 0 0 9 404.55 738.97 Tm (asthma. )Tj EMC ET BT /T1_2 1 Tf 0 Tc 9 0 0 9 433.998 738.97 Tm (N )Tj 0.372 g 1.012 0 Td (E)Tj 0.243 0.243 0.239 rg 0.0363 Tc 0.627 0 Td (ng/ )Tj 0.306 g /T1_3 1 Tf 0 Tc 8.6 0 0 8.6 462.16 738.97 Tm (J )Tj 0.243 0.243 0.239 rg /T1_2 1 Tf -0.0128 Tc 9 0 0 9 469.05 738.97 Tm (Med, )Tj 0.306 g /T1_0 1 Tf -0.0113 Tc 2.356 0 Td (1983, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0156 Tc 9 0 0 9 512.061 738.97 Tm (308, )Tj EMC /Suspect <>BDC 0.0237 Tc -23.727 -1.068 Td (436-439. )Tj EMC /Suspect <>BDC -0.0289 Tc 0.052 -1.119 Td (20. )Tj EMC /Suspect <>BDC 0.243 0.243 0.239 rg 0.0063 Tc 1.974 0 Td (Bisgaard )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.8136 0 0 9 351.32 719.29 Tm (H, )Tj -0.0059 Tc 9 0 0 9 362.31 719.29 Tm (Groth )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0248 Tc 9 0 0 9 385.278 719.29 Tm (S, )Tj EMC ET BT 0.137 g /T1_0 1 Tf 0 Tc 9 0 0 9 394.998 719.29 Tm (M)Tj 0.306 g -0.006 Tc 0.901 0 Td (asden )Tj 0.243 0.243 0.239 rg /T1_1 1 Tf -0.035 Tc 8.2591 0 0 8.8 425.56 719.29 Tm (F.)Tj 0.447 0.451 0.447 rg 0 Tc 8.8 0 0 8.8 434.8 719.29 Tm (-)Tj 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0103 Tc 9 0 0 9 442.04 719.29 Tm (Bronchial )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0023 Tc 9 0 0 9 479.993 719.29 Tm (hyperreactiv)Tj 0.372 g 0 Tc 5.057 0 Td (\255)Tj EMC ET BT 0.023 g /T1_0 1 Tf 9 0 0 9 298.976 709.678 Tm (i)Tj 0.306 g -0.028 Tc 0.272 0 Td (ty )Tj 0.243 0.243 0.239 rg 0 Tc 1.227 0 Td (t)Tj 0.372 g 0.206 0 Td (o )Tj 0.243 0.243 0.239 rg 0.961 0 Td (l)Tj 0.372 g 0.264 0 Td (e)Tj 0.243 0.243 0.239 rg -0.0049 Tc 0.491 0 Td (ukotriene )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0 Tc 9.2 0 0 9.2 367.09 709.68 Tm (0)Tj /T1_0 1 Tf 5.9001 0 0 5.9001 373.42 706.8 Tm (4 )Tj EMC ET BT /T1_0 1 Tf -0.0142 Tc 9 0 0 9 380.57 709.68 Tm (in )Tj -0.0166 Tc 1.17 0 Td (ex)Tj 0.372 g -0.0057 Tc 0.961 0 Td (ogeno)Tj 0.243 0.243 0.239 rg 0 Tc 2.463 0 Td (u)Tj 0.372 g 0.466 0 Td (s )Tj 0.243 0.243 0.239 rg 0.0017 Tc 0.858 0 Td (asthma)Tj 0.372 g 0 Tc 2.869 0 Td (. )Tj 0.243 0.243 0.239 rg /T1_2 1 Tf 0.05 Tc 9.1463 0 0 9 465.19 709.68 Tm (Br )Tj -0.035 Tc 9.6274 0 0 10 477.7 709.68 Tm (Med )Tj ET BT /Suspect <>BDC /T1_3 1 Tf 0.0035 Tc 8.6 0 0 8.6 497.2 709.68 Tm (J, )Tj EMC ET BT /T1_0 1 Tf -0.0113 Tc 9 0 0 9 508.49 709.68 Tm (1985, )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.0081 Tc 9 0 0 9 298.511 700.563 Tm (290, )Tj EMC /Suspect <>BDC 0.243 0.243 0.239 rg -0.0206 Tc 2.211 0 Td (1468)Tj 0.372 g 0 Tc 1.89 0 Td (-)Tj 0.243 0.243 0.239 rg 0.002 Tc 0.563 0 Td (1471. )Tj EMC ET BT 0.306 g /T1_0 1 Tf -0.0022 Tc 9 0 0 9 298.511 690.006 Tm (21. )Tj 0.243 0.243 0.239 rg 0.0119 Tc 2.028 0 Td (Ma)Tj 0.372 g -0.005 Tc 1.328 0 Td (cklem )Tj 0.243 0.243 0.239 rg -0.035 Tc 9.3789 0 0 9.5 353.24 690 Tm (PT. )Tj 0.0096 Tc 9 0 0 9 368.6 690 Tm (Mead )Tj 0 Tc 9.5 0 0 9.5 392.11 690 Tm (J)Tj 0.372 g 0.388 0 Td (. )Tj 0.306 g 0.414 0 Td (-)Tj 0.243 0.243 0.239 rg 9 0 0 9 407.48 690 Tm (R)Tj 0.372 g 0.012 Tc 0.633 0 Td (esistance )Tj 0.306 g 0.05 Tc 9.4598 0 0 9 448.71 690 Tm (of )Tj 0.0129 Tc 9 0 0 9 458.79 690 Tm (central )Tj 0.004 Tc 3.093 0 Td (and )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0032 Tc 9 0 0 9 502.089 690 Tm (periph)Tj 0.447 0.451 0.447 rg 0 Tc 2.601 0 Td (\255)Tj EMC ET BT 0.372 g /T1_0 1 Tf 0.0057 Tc 9 0 0 9 298.455 680.406 Tm (eral )Tj 0.306 g -0.0093 Tc 1.921 0 Td (airways )Tj 0.243 0.243 0.239 rg 0 Tc 3.368 0 Td (m)Tj 0.372 g -0.0143 Tc 0.844 0 Td (eas)Tj 0.243 0.243 0.239 rg -0.0051 Tc 1.291 0 Td (ured )Tj 0.306 g -0.0086 Tc 8.8 0 0 8.8 384.49 680.41 Tm (by )Tj 0.0002 Tc 9 0 0 9 396.47 680.41 Tm (retrograde )Tj 0.372 g 0.003 Tc 4.471 0 Td (catheter. )Tj 0.243 0.243 0.239 rg /T1_2 1 Tf 0 Tc 3.754 0 Td (J )Tj 0.0304 Tc 0.858 0 Td (Appl )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0184 Tc 9 0 0 9 498.305 680.41 Tm (Phy)Tj 0.372 g 0.0061 Tc 1.596 0 Td (sio)Tj 0.243 0.243 0.239 rg -0.035 Tc 8.8532 0 0 9 523.1 680.41 Tm (l, )Tj EMC ET BT 0.306 g /T1_0 1 Tf -0.0246 Tc 9 0 0 9 299.21 671.29 Tm (1967, )Tj -0.0022 Tc 2.536 0 Td (22, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0267 Tc 9 0 0 9 336.38 671.29 Tm (395-401. )Tj EMC ET BT 0.372 g /T1_0 1 Tf 0.0245 Tc 9 0 0 9 298.031 660.733 Tm (22. )Tj 0.243 0.243 0.239 rg 0.0119 Tc 2.028 0 Td (Ma)Tj 0.372 g 0.0083 Tc 1.328 0 Td (cklem )Tj 0.243 0.243 0.239 rg -0.035 Tc 9.3789 0 0 9.5 354.68 660.73 Tm (PT. )Tj -0.0042 Tc 9 0 0 9 371.49 660.73 Tm (Wils)Tj 0.372 g 0.0337 Tc 1.86 0 Td (on )Tj 0.306 g -0.0139 Tc 1.508 0 Td (NJ. )Tj 0.447 0.451 0.447 rg 0 Tc 1.744 0 Td (-)Tj 0.306 g 0.012 Tc 1.02 0 Td (Measurement )Tj 0.243 0.243 0.239 rg 0.05 Tc 9.4598 0 0 9 480.39 660.73 Tm (of )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.0092 Tc 9 0 0 9 492.41 660.73 Tm (intrabron)Tj 0.447 0.451 0.447 rg 0 Tc 3.623 0 Td (\255)Tj EMC /Suspect <>BDC 0.306 g /T1_1 1 Tf -0.035 Tc 8.5877 0 0 8.8 298.46 651.12 Tm (ctual )Tj EMC ET BT /T1_0 1 Tf 0.0056 Tc 9 0 0 9 319.21 651.12 Tm (pressure )Tj /T1_1 1 Tf 0.0259 Tc 8.8 0 0 8.8 352.63 651.12 Tm (in )Tj 0.243 0.243 0.239 rg /T1_0 1 Tf -0.0044 Tc 9 0 0 9 362.86 651.12 Tm (man)Tj 0.372 g 0 Tc 1.741 0 Td (. )Tj 0.243 0.243 0.239 rg /T1_2 1 Tf 0.566 0 Td (J )Tj 0.306 g 0.0304 Tc 0.804 0 Td (Appl )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_2 1 Tf -0.0003 Tc 9 0 0 9 411.91 651.12 Tm (Ph)Tj 0.372 g 0.025 Tc 1.03 0 Td (ysio)Tj 0.243 0.243 0.239 rg 0 Tc 1.671 0 Td (l)Tj 0.372 g 0.334 0 Td (, )Tj EMC ET BT 0.306 g /T1_0 1 Tf -0.0246 Tc 9 0 0 9 445.129 651.12 Tm (1965, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0022 Tc 9 0 0 9 467.953 651.12 Tm (20, )Tj EMC ET BT 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0175 Tc 9 0 0 9 482.776 651.12 Tm (653-663)Tj 0.372 g 0 Tc 3.511 0 Td (. )Tj ET BT /Suspect <>BDC 0.306 g /T1_2 1 Tf 0.0074 Tc 9 0 0 9 298.159 612.726 Tm (Reactivite )Tj EMC /Suspect <>BDC 0.0105 Tc 4.464 0 Td (comparee )Tj EMC /Suspect <>BDC 0.243 0.243 0.239 rg 0 Tc 14.4 0 0 14.4 378.14 612.73 Tm (a )Tj EMC ET BT /T1_2 1 Tf 0.0104 Tc 9 0 0 9 387.46 612.73 Tm (/'inhalati)Tj 0.372 g 0.0334 Tc 3.714 0 Td (on )Tj 0.306 g 0.0005 Tc 1.496 0 Td (de )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_2 1 Tf 0 Tc 9 0 0 9 447.742 612.73 Tm (l)Tj 0.372 g 0.216 0 Td (e)Tj 0.243 0.243 0.239 rg 0.0036 Tc 0.481 0 Td (ulwtriene )Tj EMC /Suspect <>BDC 0 Tc 4.282 0 Td (E)Tj 5.9001 0 0 5.9001 497.71 608.89 Tm (4)Tj 0.581 0.651 Td (, )Tj EMC ET BT /T1_2 1 Tf 0.0005 Tc 9 0 0 9 507.79 612.73 Tm (de )Tj ET BT /Suspect <>BDC 0.306 g /T1_2 1 Tf -0.035 Tc 7.5224 0 0 9.7 520.88 612.73 Tm (Ia )Tj EMC /Suspect <>BDC 0.243 0.243 0.239 rg -0.0015 Tc 9 0 0 9 298.04 602.65 Tm (meta)Tj 0.372 g 0.0052 Tc 1.917 0 Td (cho)Tj 0.243 0.243 0.239 rg 0.0001 Tc 1.49 0 Td (line )Tj EMC ET BT /T1_2 1 Tf -0.0132 Tc 9 0 0 9 344.561 602.65 Tm (et )Tj 0.0172 Tc 0.91 0 Td (d' )Tj 0.0031 Tc 0.853 0 Td (histamine)Tj 0.372 g 0 Tc 3.902 0 Td (, )Tj 0.306 g -0.0005 Tc 0.469 0 Td (chez )Tj 0.243 0.243 0.239 rg 0.0191 Tc 2.029 0 Td (des )Tj 0.306 g 0.0046 Tc 1.609 0 Td (sujets )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_2 1 Tf 0.0059 Tc 9 0 0 9 455.468 602.65 Tm (normaux )Tj EMC ET BT /T1_2 1 Tf 0.05 Tc 9.517 0 0 9 489.52 602.65 Tm (et )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0002 Tc 9 0 0 9 498.66 602.65 Tm (asthma)Tj 0.447 0.451 0.447 rg 0 Tc 2.879 0 Td (\255)Tj EMC /Suspect <>BDC 0.243 0.243 0.239 rg -0.0028 Tc -25.178 -1.067 Td (tiques. )Tj EMC ET BT 0.306 g /T1_2 1 Tf -0.035 Tc 9.2626 0 0 9.7 323.99 593.05 Tm (S. )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_2 1 Tf -0.017 Tc 9 0 0 9 333.67 593.05 Tm (P. )Tj EMC /Suspect <>BDC 0.05 Tc 11.6255 0 0 9.7 343.96 593.05 Tm (0' )Tj EMC ET BT /T1_2 1 Tf -0.0025 Tc 9 0 0 9 353.36 593.05 Tm (Hickey, )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.05 Tc 10.3141 0 0 9 383.15 593.05 Tm (J.P)Tj 0.372 g 0 Tc 9 0 0 9 398.31 593.05 Tm (. )Tj EMC ET BT 0.243 0.243 0.239 rg /T1_2 1 Tf 0.0201 Tc 9 0 0 9 401.901 593.05 Tm (Arm, )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0 Tc 9 0 0 9 422.952 593.05 Tm (P)Tj 0.525 g 0.676 0 Td (. )Tj EMC ET BT 0.243 0.243 0.239 rg /T1_3 1 Tf -0.035 Tc 8.3997 0 0 8.9 432.88 593.05 Tm (J. )Tj /T1_2 1 Tf 0.0003 Tc 9 0 0 9 442.15 593.05 Tm (Rees, )Tj -0.0073 Tc 2.453 0 Td (B. )Tj -0.035 Tc 8.7328 0 0 9.7 474.41 593.05 Tm (W. )Tj -0.004 Tc 9 0 0 9 486.71 593.05 Tm (Spur, )Tj -0.035 Tc 8.6418 0 0 9 508.62 593.05 Tm (T. )Tj 8.8973 0 0 9 518.48 593.05 Tm (H. )Tj ET BT /Suspect <>BDC 0.306 g /T1_2 1 Tf 9.7977 0 0 10 297.7 583.44 Tm (Lee)Tj 0.525 g 0 Tc 10 0 0 10 311.42 583.44 Tm (. )Tj EMC /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0063 Tc 9 0 0 9 298.04 573.36 Tm (RE)Tj 0.372 g 0 Tc 1.267 0 Td (S)Tj 0.243 0.243 0.239 rg -0.0146 Tc 0.603 0 Td (UME)Tj 0.372 g 0 Tc 2.216 0 Td (: )Tj EMC ET BT 0.243 0.243 0.239 rg /T1_0 1 Tf -0.0274 Tc 9 0 0 9 339.791 573.36 Tm (La )Tj 0.0023 Tc 1.233 0 Td (puissance )Tj -0.0034 Tc 4.213 0 Td (bron)Tj 0.372 g -0.0048 Tc 1.802 0 Td (choco)Tj 0.243 0.243 0.239 rg 0.0055 Tc 2.409 0 Td (nstrictri)Tj 0.372 g 0.05 Tc 9.4329 0 0 9 454.47 573.36 Tm (ce )Tj 0.243 0.243 0.239 rg 0.0068 Tc 9 0 0 9 465.11 573.36 Tm (relative )Tj 0.306 g 0.026 Tc 3.299 0 Td (de )Tj 0.243 0.243 0.239 rg -0.0022 Tc 1.23 0 Td (LTE)Tj 0 Tc 5.9001 0 0 5.9001 521.74 569.53 Tm (4)Tj 0.137 g 0.558 0.649 Td (, )Tj 0.243 0.243 0.239 rg 9 0 0 9 298 563.76 Tm (d)Tj 0.372 g 0.478 0 Td (e )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf 9 0 0 9 310.024 563.76 Tm (I)Tj 0.372 g 0.317 0 Td (a )Tj EMC ET BT 0.306 g /T1_0 1 Tf -0.0022 Tc 9 0 0 9 320.626 563.76 Tm (metacholine )Tj 0.243 0.243 0.239 rg 0.05 Tc 9.5969 0 0 9 367.58 563.76 Tm (et )Tj 0.306 g 0.026 Tc 9 0 0 9 377.68 563.76 Tm (de )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf 0.0204 Tc 9 0 0 9 389.94 563.76 Tm (!'histamine )Tj EMC ET BT 0.306 g /T1_0 1 Tf 0 Tc 9 0 0 9 434.787 563.76 Tm (a )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0417 Tc 9 0 0 9 441.978 563.76 Tm (ete )Tj EMC /Suspect <>BDC 0.372 g 0.0371 Tc 1.601 0 Td (co)Tj 0.243 0.243 0.239 rg -0.0002 Tc 0.968 0 Td (mparee )Tj EMC ET BT 0.306 g /T1_0 1 Tf 0.0192 Tc 9 0 0 9 495.267 563.76 Tm (chez )Tj 0.372 g 0.0362 Tc 8.6 0 0 8.6 515.44 563.76 Tm (des )Tj 0 Tc 9 0 0 9 297.95 553.68 Tm (s)Tj 0.243 0.243 0.239 rg 0.388 0 Td (u)Tj 0.372 g 0.0186 Tc 0.45 0 Td (jets )Tj 0.306 g 0.0021 Tc 1.727 0 Td (asthmatiques )Tj 0.372 g 0.05 Tc 9.5969 0 0 9 370.46 553.68 Tm (et )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0049 Tc 9 0 0 9 380.15 553.68 Tm (normaux)Tj 0.525 g 0 Tc 3.553 0 Td (. )Tj EMC ET BT 0.306 g /T1_0 1 Tf -0.035 Tc 9.0679 0 0 9.3 417.55 553.68 Tm (La )Tj ET BT /Suspect <>BDC 0.372 g /T1_0 1 Tf 0.0023 Tc 9 0 0 9 429.59 553.68 Tm (reactivite )Tj EMC ET BT 0.306 g /T1_0 1 Tf 0.0052 Tc 9 0 0 9 465.518 553.68 Tm (des )Tj ET BT /Suspect <>BDC 0.372 g /T1_0 1 Tf -0.0076 Tc 9 0 0 9 480.872 553.68 Tm (asthmatiques )Tj EMC /Suspect <>BDC 0.0448 Tc -20.319 -1.119 Td (lll'egard )Tj EMC ET BT 0.306 g /T1_0 1 Tf 0.026 Tc 9 0 0 9 333.038 543.609 Tm (de )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf -0.0022 Tc 9 0 0 9 344.585 543.609 Tm (LTE)Tj 0.372 g -0.0008 Tc 1.746 0 Td (;\225 )Tj EMC /Suspect <>BDC -0.035 Tc 8.3463 0 0 9 368.55 543.61 Tm (ex_pcim6e )Tj EMC ET BT /T1_0 1 Tf 0.0332 Tc 9 0 0 9 405.13 543.61 Tm (par )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf 0 Tc 9 0 0 9 419.944 543.61 Tm (I)Tj 0.372 g 0.263 0 Td (a )Tj EMC ET BT /T1_0 1 Tf 0.0146 Tc 9 0 0 9 429.043 543.61 Tm (dose )Tj 0.0066 Tc 2.133 0 Td (qui )Tj 0.0092 Tc 1.61 0 Td (produit )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.1064 0 0 9 491.93 543.61 Tm (lUle )Tj EMC /Suspect <>BDC -0.0024 Tc 9 0 0 9 507.75 543.61 Tm (chute )Tj EMC ET BT 0.306 g /T1_0 1 Tf 0.05 Tc 9.2683 0 0 9 297.51 533.53 Tm (de )Tj ET BT /Suspect <>BDC 0.372 g /T1_0 1 Tf 0.0353 Tc 9 0 0 9 308.06 533.53 Tm (35% )Tj EMC ET BT 0.306 g /T1_0 1 Tf 0.026 Tc 9 0 0 9 326.798 533.53 Tm (de )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf -0.035 Tc 8.5916 0 0 9 337.86 533.53 Tm (Ia )Tj EMC ET BT 0.306 g /T1_0 1 Tf 0.0041 Tc 9 0 0 9 345.99 533.53 Tm (conductance )Tj ET BT /Suspect <>BDC 0.447 0.451 0.447 rg /T1_0 1 Tf 0.0092 Tc 9 0 0 9 392.511 533.53 Tm (specilique )Tj EMC /Suspect <>BDC 0.372 g 0.0052 Tc 4.326 0 Td (des )Tj EMC ET BT /T1_0 1 Tf -0.0059 Tc 9 0 0 9 445.908 533.53 Tm (voics )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0119 Tc 9 0 0 9 466.959 533.53 Tm (aenennes )Tj EMC /Suspect <>BDC 0.306 g -0.035 Tc 8.8224 0 0 9 502.46 533.53 Tm (\(POlS)Tj 0.447 0.451 0.447 rg 0.0392 Tc 9 0 0 9 522.66 533.53 Tm (\)' )Tj EMC ET BT 0.372 g /T1_0 1 Tf 0.009 Tc 9 0 0 9 297.579 523.918 Tm (varie )Tj 0.0126 Tc 2.284 0 Td (entre )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf 0.0105 Tc 9 0 0 9 338.304 523.918 Tm (0.06 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.5969 0 0 9 356.06 523.92 Tm (et )Tj 0.0096 Tc 9 0 0 9 365.23 523.92 Tm (24.4 )Tj -0.008 Tc 2.031 0 Td (nmol )Tj 0.372 g 0.0033 Tc 2.336 0 Td (\(moyenne )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.0026 Tc 9 0 0 9 442.963 523.92 Tm (geometrique: )Tj EMC ET BT /T1_0 1 Tf -0.004 Tc 9 0 0 9 492.445 523.92 Tm (4.1 )Tj -0.0152 Tc 1.55 0 Td (nmol, )Tj 0.372 g 0 Tc -23.147 -1.119 Td (n)Tj 0.525 g 0.477 0 Td (=)Tj 0.306 g 0.0322 Tc 0.532 0 Td (20)Tj 0.447 0.451 0.447 rg -0.0308 Tc 1.012 0 Td (\). )Tj 0.372 g 0.0122 Tc 0.797 0 Td (Cette )Tj 0.306 g 0.0032 Tc 2.408 0 Td (valeur )Tj -0.0113 Tc 2.711 0 Td (est )Tj 0.372 g 0.0024 Tc 1.33 0 Td (significativemen)Tj 0.243 0.243 0.239 rg 0 Tc 6.732 0 Td (t )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.0012 Tc 9 0 0 9 446.41 513.849 Tm (plus )Tj EMC ET BT /T1_0 1 Tf -0.0104 Tc 9 0 0 9 464.059 513.849 Tm (faible )Tj ET BT /Suspect <>BDC 0.372 g /T1_0 1 Tf 0.0303 Tc 9 0 0 9 486.163 513.849 Tm (que )Tj EMC ET BT 0.306 g /T1_0 1 Tf -0.035 Tc 8.5916 0 0 9 501.54 513.85 Tm (Ia )Tj ET BT /Suspect <>BDC 0.243 0.243 0.239 rg /T1_0 1 Tf 0.026 Tc 9.9 0 0 9.9 510.68 513.85 Tm (P0)Tj 0.372 g 0.0119 Tc 6.4001 0 0 6.4001 521.21 510 Tm (35 )Tj EMC /Suspect <>BDC 0.0052 Tc 9 0 0 9 297.52 504.25 Tm (des )Tj EMC ET BT /T1_0 1 Tf 0.0087 Tc 9 0 0 9 314.269 504.25 Tm (sujets )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.0138 Tc 9 0 0 9 340.306 504.25 Tm (normaux )Tj EMC /Suspect <>BDC 0.447 0.451 0.447 rg -0.035 Tc 8.3757 0 0 9 377.18 504.25 Tm (\(eJt)Tj 0.306 g -0.021 Tc 9 0 0 9 388.78 504.25 Tm (tr)Tj 0.447 0.451 0.447 rg -0.0173 Tc 0.578 0 Td (emcs: )Tj EMC /Suspect <>BDC 0.372 g 0.0156 Tc 2.88 0 Td (39.0 )Tj EMC /Suspect <>BDC -0.035 Tc 6.67 0 0 9 441.07 504.25 Tm (ll )Tj EMC /Suspect <>BDC 0.0418 Tc 9 0 0 9 449.66 504.25 Tm (370 )Tj EMC ET BT 0.306 g /T1_0 1 Tf -0.0152 Tc 9 0 0 9 468.947 504.25 Tm (nmol, )Tj 0.0036 Tc 2.772 0 Td (moyennc )Tj ET BT /Suspect <>BDC 0.372 g /T1_0 1 Tf -0.0078 Tc 9 0 0 9 297.515 494.647 Tm (goometrique: )Tj EMC /Suspect <>BDC -0.021 Tc 5.788 0 Td (105 )Tj EMC ET BT 0.306 g /T1_0 1 Tf -0.0152 Tc 9 0 0 9 367.184 494.647 Tm (nmol, )Tj 0 Tc 2.773 0 Td (n)Tj 0.525 g 0.477 0 Td (=)Tj 0.372 g 0.526 0 Td (6)Tj 0.525 g 0.583 0 Td (, )Tj ET BT /Suspect <>BDC 0.372 g /T1_0 1 Tf -0.035 Tc 8.5111 0 0 9.7 412.81 494.65 Tm (p>BDC 0.372 g /T1_0 1 Tf 0.0184 Tc 9 0 0 9 481.828 494.65 Tm (obse)Tj 0.243 0.243 0.239 rg -0.035 Tc 8.4243 0 0 9 498.71 494.65 Tm (rv)Tj 0.372 g 0 Tc 9 0 0 9 505.82 494.65 Tm (e )Tj EMC ET BT /T1_0 1 Tf -0.0012 Tc 9 0 0 9 514.082 494.65 Tm (une )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0323 Tc 9 0 0 9 297.515 484.561 Tm (corr61ntion )Tj EMC ET BT /T1_0 1 Tf -0.0007 Tc 9 0 0 9 341.669 484.561 Tm (entre )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.9307 0 0 9 365.23 484.56 Tm (Ia )Tj EMC /Suspect <>BDC 0.306 g -0.0227 Tc 9 0 0 9 376.79 484.56 Tm (rea)Tj 0.447 0.451 0.447 rg 0 Tc 1.164 0 Td (c)Tj 0.243 0.243 0.239 rg 0.541 0 Td (t)Tj 0.372 g 0.0139 Tc 0.208 0 Td (ivite )Tj EMC /Suspect <>BDC /T1_1 1 Tf 0 Tc 9.1 0 0 9.1 415.69 484.56 Tm (A )Tj EMC ET BT 0.306 g /T1_0 1 Tf 9 0 0 9 425.23 484.56 Tm (L )Tj ET BT /Suspect <>BDC 0.372 g /C0_0 1 Tf 4.8 0 0 6.72 429.61 484.56 Tm <00540045007E0020>Tj EMC ET BT /T1_0 1 Tf 0.0467 Tc 9 0 0 9 449.19 484.56 Tm (ct )Tj ET BT /Suspect <>BDC 0.137 g /T1_0 1 Tf 0 Tc 9 0 0 9 461.223 484.56 Tm (I)Tj 0.306 g 0.317 0 Td (a )Tj EMC /Suspect <>BDC -0.0047 Tc 0.969 0 Td (react)Tj 0.137 g 0 Tc 1.967 0 Td (i)Tj 0.372 g 0.0006 Tc 0.272 0 Td (vite )Tj EMC /Suspect <>BDC 0.306 g 0 Tc 13.4 0 0 13.4 511.54 484.56 Tm (a )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 7.9307 0 0 9 520.75 484.56 Tm (Ia )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0052 Tc 9 0 0 9 297.58 474.97 Tm (meta)Tj 0.447 0.451 0.447 rg 0 Tc 1.912 0 Td (c)Tj 0.306 g 0.0027 Tc 0.489 0 Td (holine )Tj EMC /Suspect <>BDC 0.372 g -0.0014 Tc 2.869 0 Td (\(r=0.84, )Tj EMC /Suspect <>BDC 0.306 g -0.035 Tc 8.4409 0 0 9 377.77 474.97 Tm (p>BDC /C0_0 1 Tf 0 Tc 3.6481 0 0 6.72 482.89 474.97 Tm <007200650061006300740069007600690074007E0020>Tj EMC /Suspect <>BDC 0.372 g 3.36 0 0 6.72 523.21 474.97 Tm <007E0020>Tj EMC /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.035 Tc 8.7818 0 0 9 298.03 464.89 Tm (LTB)Tj 0 Tc 5.1 0 0 5.1 313.9 462 Tm (4 )Tj EMC ET BT 0.372 g /T1_0 1 Tf 0.0467 Tc 9 0 0 9 319.59 464.89 Tm (ct )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0313 Tc 9 0 0 9 329.202 464.89 Tm (ltl'hismmine )Tj EMC /Suspect <>BDC -0.0014 Tc 5.597 0 Td (\(r=0.79. )Tj EMC /Suspect <>BDC 0.306 g 0 Tc 3.587 0 Td (p)Tj 0.447 0.451 0.447 rg -0.035 Tc 7.1305 0 0 9 416.61 464.89 Tm (>BDC 0.372 g 0.0131 Tc 0.961 0 Td (L'fE )Tj EMC ET BT /T1_0 1 Tf 0.0401 Tc 9 0 0 9 472.182 464.89 Tm (s'est )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.0296 Tc 9 0 0 9 491.901 464.89 Tm (av6r6e )Tj EMC ET BT 0.372 g /T1_0 1 Tf -0.0154 Tc 9 0 0 9 517.812 464.89 Tm (73 )Tj -0.0083 Tc -24.48 -1.12 Td (fois )Tj 0.306 g -0.0207 Tc 1.879 0 Td (plu)Tj 0.447 0.451 0.447 rg 0 Tc 1.264 0 Td (s )Tj 0.372 g 0.003 Tc 0.816 0 Td (puissante )Tj 0.0036 Tc 4.097 0 Td (que )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.035 Tc 8.5916 0 0 9 386.82 454.81 Tm (Ia )Tj EMC /Suspect <>BDC 0.372 g -0.0208 Tc 9 0 0 9 396.46 454.81 Tm (mchacholinc, )Tj EMC ET BT /T1_0 1 Tf 0.0467 Tc 9 0 0 9 446.311 454.81 Tm (ct )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.8327 0 0 9 457.61 454.81 Tm (112 )Tj EMC ET BT 0.306 g /T1_0 1 Tf 8.8311 0 0 9 474.14 454.81 Tm (fois )Tj 0.243 0.243 0.239 rg 0 Tc 9 0 0 9 490.57 454.81 Tm (p)Tj 0.372 g 0.0113 Tc 0.47 0 Td (lus )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.019 Tc 9 0 0 9 509.29 454.81 Tm (puis)Tj 0.525 g 0 Tc 1.641 0 Td (\255)Tj EMC ET BT 0.447 0.451 0.447 rg /T1_0 1 Tf 0.0133 Tc 9 0 0 9 296.989 445.207 Tm (sante )Tj 0.372 g 0.0036 Tc 2.566 0 Td (que )Tj ET BT /Suspect <>BDC 0.306 g /T1_0 1 Tf 0.0151 Tc 9 0 0 9 337.147 445.207 Tm (!'histamine )Tj EMC /Suspect <>BDC 0.372 g 0.0192 Tc 4.93 0 Td (chez )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.9085 0 0 9 402.65 445.21 Tm (lcs )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0247 Tc 9 0 0 9 416.03 445.21 Tm (sujetS )Tj EMC ET BT /T1_0 1 Tf -0.0012 Tc 9 0 0 9 441.032 445.21 Tm (aslhmatiques. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0165 Tc 9 0 0 9 494.312 445.21 Tm (Chez )Tj EMC ET BT /T1_0 1 Tf -0.0135 Tc 9 0 0 9 516.884 445.21 Tm (les )Tj 0.447 0.451 0.447 rg 0.0087 Tc -24.379 -1.121 Td (sujcts )Tj ET BT /Suspect <>BDC 0.372 g /T1_0 1 Tf 0.0058 Tc 9 0 0 9 323.996 435.121 Tm (normaux, )Tj EMC ET BT 0.306 g /T1_0 1 Tf -0.0022 Tc 9 0 0 9 365.234 435.121 Tm (LTE)Tj 0 Tc 5.6 0 0 5.6 381.58 431.76 Tm (4 )Tj 0.372 g 0.0154 Tc 9 0 0 9 390.14 435.12 Tm (est )Tj ET BT /Suspect <>BDC 0.447 0.451 0.447 rg /T1_0 1 Tf 0.0322 Tc 9 0 0 9 405.548 435.12 Tm (20 )Tj EMC ET BT 0.372 g /T1_0 1 Tf -0.0083 Tc 9 0 0 9 420.857 435.12 Tm (fois )Tj 0.0166 Tc 2.146 0 Td (plus )Tj -0.0224 Tc 2.347 0 Td (puis-sante )Tj 0.0303 Tc 4.417 0 Td (que )Tj -0.0114 Tc 2.08 0 Td (la )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0022 Tc 9 0 0 9 297.584 425.049 Tm (metacholine )Tj EMC /Suspect <>BDC 0.05 Tc 8.3207 0 0 8 343.6 425.05 Tm (ct )Tj EMC ET BT /T1_2 1 Tf -0.035 Tc 9.115 0 0 10 352.71 425.05 Tm (58 )Tj /T1_0 1 Tf -0.0083 Tc 9 0 0 9 364.22 425.05 Tm (fois )Tj -0.0012 Tc 1.772 0 Td (plus )Tj 0.003 Tc 1.973 0 Td (puissantc )Tj 0.0036 Tc 3.99 0 Td (que )Tj 0.0381 Tc 1.76 0 Td (l'his)Tj 0.243 0.243 0.239 rg 0 Tc 1.82 0 Td (t)Tj 0.023 g 0.141 0 Td (.)Tj 0.372 g -0.0025 Tc 0.064 0 Td (aminc. )Tj 0.243 0.243 0.239 rg 0 Tc 3.044 0 Td (L)Tj 0.372 g 0.05 Tc 9.19 0 0 9 499.6 425.05 Tm (TE)Tj 0 Tc 5.5001 0 0 5.5001 510.7 421.69 Tm (4 )Tj 0.447 0.451 0.447 rg -0.0122 Tc 9 0 0 9 516.38 425.05 Tm (es)Tj 0.243 0.243 0.239 rg 0 Tc 0.916 0 Td (t )Tj 0.372 g 0.0131 Tc -25.287 -1.068 Td (done )Tj -0.035 Tc 8.959 0 0 9 318.24 415.44 Tm (un )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0047 Tc 9 0 0 9 331.11 415.44 Tm (agent )Tj EMC ET BT /T1_0 1 Tf 0.004 Tc 9 0 0 9 354.249 415.44 Tm (bronchoconstricteur )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0005 Tc 9 0 0 9 430.092 415.44 Tm (puissant. )Tj EMC /Suspect <>BDC 0.05 Tc 8.9571 0 0 8 465.03 415.44 Tm (et )Tj EMC /Suspect <>BDC -0.0146 Tc 9 0 0 9 475.62 415.44 Tm (Ia )Tj EMC /Suspect <>BDC 0.243 0.243 0.239 rg 0 Tc 1.126 0 Td (r)Tj 0.372 g 0.0066 Tc 0.31 0 Td (eactivite )Tj EMC /Suspect <>BDC 0.447 0.451 0.447 rg /T1_1 1 Tf 0 Tc 12.4 0 0 12.4 522.59 415.44 Tm (a )Tj EMC ET BT 0.372 g /T1_0 1 Tf -0.0022 Tc 9 0 0 9 297.55 405.37 Tm (LTE)Tj 0 Tc 5.5001 0 0 5.5001 313.42 402.49 Tm (4 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0154 Tc 9 0 0 9 319.58 405.37 Tm (est )Tj EMC ET BT /T1_0 1 Tf -0.0166 Tc 9 0 0 9 333.017 405.37 Tm (en )Tj 0.0014 Tc 1.281 0 Td (correlation )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0224 Tc 8.8 0 0 8.8 387.19 405.37 Tm (i\\ )Tj EMC /Suspect <>BDC 0.306 g /T1_0 1 Tf -0.035 Tc 8.5916 0 0 9 394.5 405.37 Tm (Ia )Tj EMC ET BT 0.372 g /T1_0 1 Tf -0.0261 Tc 9 0 0 9 404.54 405.37 Tm (fois )Tj -0.0015 Tc 1.868 0 Td (avec )Tj 0.447 0.451 0.447 rg 0.0143 Tc 2.133 0 Td (ccllc )Tj ET BT /Suspect <>BDC 0.372 g /T1_0 1 Tf 0 Tc 13.4 0 0 13.4 461.14 405.37 Tm (a )Tj EMC /Suspect <>BDC 0.0123 Tc 9 0 0 9 468.95 405.37 Tm (regard )Tj EMC /Suspect <>BDC 0.05 Tc 9.7561 0 0 8.2 495.27 405.37 Tm (de )Tj EMC /Suspect <>BDC -0.017 Tc 9 0 0 9 507.53 405.37 Tm (1'his)Tj 0.525 g 0 Tc 1.827 0 Td (\267 )Tj EMC /Suspect <>BDC 0.372 g 0.0011 Tc -25.208 -1.121 Td (tamine )Tj EMC /Suspect <>BDC 0.05 Tc 11.5826 0 0 9 324.36 395.28 Tm (eta )Tj EMC /Suspect <>BDC 0.0188 Tc 9 0 0 9 342.16 395.28 Tm (l'egard )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.2683 0 0 9 370.47 395.28 Tm (de )Tj 0.243 0.243 0.239 rg 0 Tc 9 0 0 9 382.98 395.28 Tm (I)Tj 0.372 g 0.263 0 Td (a )Tj -0.023 Tc 0.861 0 Td (meta)Tj 0.525 g 0 Tc 1.912 0 Td (c)Tj 0.372 g 0.0134 Tc 0.382 0 Td (holine)Tj 0.525 g 0 Tc 2.54 0 Td (. )Tj 0.306 g /T1_2 1 Tf 0.0173 Tc -15.544 -1.066 Td (Eur )Tj 0.243 0.243 0.239 rg 0.0123 Tc 1.867 0 Td (Respir )Tj 0.306 g /T1_3 1 Tf -0.0251 Tc 8.6 0 0 8.6 340.24 385.69 Tm (J., )Tj 0.0066 Tc 8 0 0 8 352.45 385.69 Tm (1988, )Tj 0.243 0.243 0.239 rg 0.0146 Tc 2.94 0 Td (1. )Tj 0.306 g 0.05 Tc 8.1473 0 0 8 385.76 385.69 Tm (913-917)Tj 0.447 0.451 0.447 rg 0 Tc 8 0 0 8 417.95 385.69 Tm (. )Tj ET endstream endobj 73 0 obj <>stream Hd͊zy8 >sRhF^#y QG#Oç==o/ϧ;c_mӷKv|~_oo~y>}~W=|z>{O݇q~?>Ï?o+~ߒ~;%zΏx߽w;>lp?(O?{wٸ^ PZUuTGu^5P5FjFDMԤU PjVjUmFmک]uPuNNE]E5|| _#_k55|| _#_k55|| _#_k55|| _#_k5Z||-_+_kZ||-_+_kZ||-_+_kZ||-_+_ku:||_'_uu:||_'_uu:||_'_uu:||_'_uz||=_/_z||=_/_z||=_/_z||=_/_ || ߀o77 || ߀o77 || ߀o77 || ߀o77 KG#(~? ?G#(~? ?G#(~? ?G#(~? ?z $߄o77MM&|| $߄o77MM&|| $߄o77MM&|| 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