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Td (valvular )Tj 0.169 0.169 0.165 rg 0.0092 Tc 3.712 0 Td (heart )Tj 0.247 0.247 0.243 rg -0.0049 Tc 2.416 0 Td (disease; )Tj 0.169 0.169 0.165 rg 0.0132 Tc 3.571 0 Td (none )Tj 0.247 0.247 0.243 rg 0.05 Tc 10.0163 0 0 9.7 162.62 674.17 Tm (of )Tj 0.169 0.169 0.165 rg -0.0216 Tc 9.7 0 0 9.7 174.7 674.17 Tm (them )Tj 0.017 Tc 2.327 0 Td (was )Tj 0.247 0.247 0.243 rg 0 Tc 1.97 0 Td [(a )-143(smoker. )]TJ 0.169 0.169 0.165 rg 0.0235 Tc 4.406 0 Td (The )Tj 0.247 0.247 0.243 rg 0 Tc -22.022 -1.139 Td (d)Tj 0.353 0.353 0.349 rg 0.006 Tc 0.545 0 Td (iagnos)Tj 0.247 0.247 0.243 rg 0 Tc 2.722 0 Td (i)Tj 0.353 0.353 0.349 rg 0.241 0 Td (s )Tj 0.247 0.247 0.243 rg 1.141 0 Td (f)Tj 0.353 0.353 0.349 rg 0.299 0 Td (o)Tj 0.169 0.169 0.165 rg 0.553 0 Td (r )Tj 0.247 0.247 0.243 rg 0.0245 Tc 1.03 0 Td (ea)Tj 0.353 0.353 0.349 rg 0 Tc 0.941 0 Td (c)Tj 0.247 0.247 0.243 rg 0.503 0 Td (h )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0153 Tc 9.7 0 0 9.7 134.4062 663.1217 Tm (pati)Tj 0.353 0.353 0.349 rg 0 Tc 1.523 0 Td (e)Tj 0.247 0.247 0.243 rg 0.0181 Tc 0.504 0 Td (nt )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 168.9479 663.1217 Tm (h)Tj 0.353 0.353 0.349 rg 0.486 0 Td (a)Tj 0.169 0.169 0.165 rg 0.446 0 Td (d )Tj 0.247 0.247 0.243 rg 1.297 0 Td (b)Tj 0.353 0.353 0.349 rg 0.0245 Tc 0.484 0 Td (ee)Tj 0.247 0.247 0.243 rg 0 Tc 0.949 0 Td (n )Tj 0.353 0.353 0.349 rg 1.179 0 Td (c)Tj 0.247 0.247 0.243 rg 0.025 Tc 0.496 0 Td (lin)Tj 0.353 0.353 0.349 rg -0.0044 Tc 1.089 0 Td (ica)Tj 0.247 0.247 0.243 rg 0.0056 Tc 1.138 0 Td (ll)Tj 0.353 0.353 0.349 rg 0 Tc 0.651 0 Td [(y )-428(a)]TJ 0.247 0.247 0.243 rg -0.035 Tc 9.4833 0 0 9.7 264.95 663.12 Tm (nd )Tj 0.353 0.353 0.349 rg 0.05 Tc 9.9537 0 0 9.7 45.01 652.09 Tm (ec)Tj 0.247 0.247 0.243 rg 0 Tc 9.7 0 0 9.7 54.71 652.09 Tm (h)Tj 0.353 0.353 0.349 rg 0.0276 Tc 0.487 0 Td (ocar)Tj 0.247 0.247 0.243 rg -0.0257 Tc 1.781 0 Td (di)Tj 0.353 0.353 0.349 rg 0 Tc 0.792 0 Td (o)Tj 0.247 0.247 0.243 rg 0.0169 Tc 0.496 0 Td (graphi)Tj 0.353 0.353 0.349 rg 0 Tc 2.622 0 Td (c)Tj 0.247 0.247 0.243 rg -0.0229 Tc 0.494 0 Td (all)Tj 0.353 0.353 0.349 rg 0 Tc 1.048 0 Td (y )Tj 0.247 0.247 0.243 rg 0.006 Tc 1.091 0 Td (pro)Tj 0.353 0.353 0.349 rg 0.0027 Tc 1.382 0 Td (ve)Tj 0.247 0.247 0.243 rg -0.035 Tc 9.4422 0 0 9.7 163.19 652.09 Tm (n. )Tj -0.0165 Tc 9.7 0 0 9.7 176.14 652.09 Tm (All )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 194.4148 652.09 Tm (p)Tj 0.353 0.353 0.349 rg 0.483 0 Td (a)Tj 0.247 0.247 0.243 rg -0.035 Tc 9.2906 0 0 9.7 203.98 652.09 Tm (ti)Tj 0.353 0.353 0.349 rg 0 Tc 9.7 0 0 9.7 209.18 652.09 Tm (e)Tj 0.247 0.247 0.243 rg 0.0181 Tc 0.455 0 Td (nt)Tj 0.353 0.353 0.349 rg 0 Tc 0.778 0 Td (s )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 9.7 0 0 9.7 230.8692 652.09 Tm (h)Tj 0.353 0.353 0.349 rg 0.486 0 Td (a)Tj 0.247 0.247 0.243 rg 0.496 0 Td (d )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.7 0 0 9.7 251.0355 652.09 Tm (r)Tj 0.353 0.353 0.349 rg 0.337 0 Td (a)Tj 0.247 0.247 0.243 rg -0.0257 Tc 0.446 0 Td (di)Tj 0.353 0.353 0.349 rg 0.0286 Tc 0.792 0 Td (o\255)Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.9506 0 0 9.7 45.04 641.53 Tm (gr)Tj 0.247 0.247 0.243 rg -0.0088 Tc 9.7 0 0 9.7 53.66 641.53 Tm (aphi)Tj 0.353 0.353 0.349 rg 0 Tc 1.733 0 Td [(c )-295(e)]TJ 0.247 0.247 0.243 rg -0.0172 Tc 1.541 0 Td (vid)Tj 0.353 0.353 0.349 rg 0 Tc 1.229 0 Td (e)Tj 0.247 0.247 0.243 rg 0.554 0 Td (n)Tj 0.353 0.353 0.349 rg 0.05 Tc 10.481 0 0 9.7 106.94 641.53 Tm (ce )Tj 0.247 0.247 0.243 rg 0 Tc 9.7 0 0 9.7 120.87 641.53 Tm (o)Tj 0.353 0.353 0.349 rg 0.542 0 Td (f )Tj ET BT /Suspect <>BDC 0.247 0.247 0.243 rg /T1_0 1 Tf -0.0186 Tc 9.7 0 0 9.7 134.7992 641.53 Tm (in)Tj 0.353 0.353 0.349 rg -0.0015 Tc 0.798 0 Td (ters)Tj 0.247 0.247 0.243 rg -0.035 Tc 8.5358 0 0 9.7 157.42 641.53 Tm (t.it.ial )Tj EMC ET BT /T1_0 1 Tf 0.0111 Tc 9.7 0 0 9.7 180.01 641.53 Tm (pulm)Tj 0.353 0.353 0.349 rg 0 Tc 2.118 0 Td (o)Tj 0.247 0.247 0.243 rg 0.553 0 Td (n)Tj 0.353 0.353 0.349 rg 0.0108 Tc 0.486 0 Td (ary )Tj 0.247 0.247 0.243 rg 0 Tc 1.832 0 Td (o)Tj 0.353 0.353 0.349 rg 0.0344 Tc 0.494 0 Td (ede)Tj 0.247 0.247 0.243 rg 0 Tc 1.493 0 Td (m)Tj 0.353 0.353 0.349 rg 0.734 0 Td (a )Tj 0.247 0.247 0.243 rg 1.051 0 Td (b)Tj 0.353 0.353 0.349 rg 0.493 0 Td (y )Tj 0.247 0.247 0.243 rg -0.0324 Tc -23.11 -1.139 Td (th)Tj 0.353 0.353 0.349 rg 0 Tc 0.784 0 Td (e )Tj -0.035 Tc 9.398 0 0 9.7 61.82 630.48 Tm (fo)Tj 0.247 0.247 0.243 rg 0.0056 Tc 9.7 0 0 9.7 69.52 630.48 Tm (ll)Tj 0.353 0.353 0.349 rg 0 Tc 0.593 0 Td (o)Tj 0.247 0.247 0.243 rg -0.005 Tc 0.553 0 Td (win)Tj 0.353 0.353 0.349 rg 0 Tc 1.477 0 Td [(g )-140(c)]TJ 0.247 0.247 0.243 rg 0.002 Tc 1.442 0 Td (rit)Tj 0.353 0.353 0.349 rg 0 Tc 0.832 0 Td (e)Tj 0.247 0.247 0.243 rg 0.018 Tc 0.504 0 Td (ria)Tj 0.353 0.353 0.349 rg 0 Tc 1.064 0 Td (: )Tj 0.169 0.169 0.165 rg 0.0136 Tc 0.718 0 Td (hila )Tj 0.353 0.353 0.349 rg 0.0347 Tc 1.92 0 Td (\(e)Tj 0.247 0.247 0.243 rg 0.0113 Tc 0.802 0 Td (nlar)Tj 0.353 0.353 0.349 rg 0.0179 Tc 1.576 0 Td (ged, )Tj 0.247 0.247 0.243 rg -0.035 Tc 9.2582 0 0 9.7 202 630.48 Tm (in)Tj 0.353 0.353 0.349 rg 0 Tc 9.7 0 0 9.7 209.19 630.48 Tm (c)Tj 0.247 0.247 0.243 rg 0.503 0 Td (r)Tj 0.353 0.353 0.349 rg 0.0277 Tc 0.288 0 Td (ease)Tj 0.247 0.247 0.243 rg 0 Tc 1.782 0 Td [(d )-141(d)]TJ 0.353 0.353 0.349 rg 1.434 0 Td (e)Tj 0.247 0.247 0.243 rg 0.504 0 Td (n)Tj 0.353 0.353 0.349 rg 0.481 0 Td (s)Tj 0.247 0.247 0.243 rg -0.035 Tc 8.5911 0 0 9.7 262.01 630.48 Tm (it)Tj 0.353 0.353 0.349 rg 9.4424 0 0 9.7 267.35 630.48 Tm (y, )Tj 0 Tc 9.7 0 0 9.7 45.61 619.44 Tm (b)Tj 0.247 0.247 0.243 rg 0.0009 Tc 0.486 0 Td (lurred)Tj 0.353 0.353 0.349 rg 0.0027 Tc 2.427 0 Td (\); )Tj 0.247 0.247 0.243 rg 0 Tc 1.239 0 Td (K)Tj 0.353 0.353 0.349 rg 0.687 0 Td (e)Tj 0.247 0.247 0.243 rg 0.0336 Tc 0.455 0 Td (rl)Tj 0.353 0.353 0.349 rg 0 Tc 0.634 0 Td (e)Tj 0.247 0.247 0.243 rg 0.504 0 Td (y )Tj 0.169 0.169 0.165 rg 0.0002 Tc 1.032 0 Td (lin)Tj 0.353 0.353 0.349 rg -0.0003 Tc 1.087 0 Td (es; )Tj 0.247 0.247 0.243 rg -0.0104 Tc 1.691 0 Td (mi)Tj 0.353 0.353 0.349 rg 0 Tc 1.032 0 Td (c)Tj 0.247 0.247 0.243 rg 0.553 0 Td (r)Tj 0.353 0.353 0.349 rg 0.289 0 Td (o)Tj 0.247 0.247 0.243 rg 0.553 0 Td (n)Tj 0.353 0.353 0.349 rg 0.487 0 Td (o)Tj 0.247 0.247 0.243 rg 0.0128 Tc 0.495 0 Td (duli)Tj 0.353 0.353 0.349 rg 0 Tc 1.622 0 Td (; )Tj 0.247 0.247 0.243 rg 0.813 0 Td (p)Tj 0.353 0.353 0.349 rg 0.483 0 Td (e)Tj 0.169 0.169 0.165 rg -0.0159 Tc 0.504 0 Td (ri)Tj 0.353 0.353 0.349 rg 0 Tc 0.645 0 Td (b)Tj 0.247 0.247 0.243 rg 0.493 0 Td (r)Tj 0.353 0.353 0.349 rg 0.338 0 Td (o)Tj 0.247 0.247 0.243 rg 0.553 0 Td (n)Tj 0.353 0.353 0.349 rg 0.487 0 Td (c)Tj 0.247 0.247 0.243 rg -0.0308 Tc 0.454 0 Td (hi)Tj 0.353 0.353 0.349 rg 0 Tc 0.782 0 Td (a)Tj 0.071 0.071 0.067 rg 0.497 0 Td (l )Tj 0.247 0.247 0.243 rg 0.0016 Tc 0.79 0 Td (and )Tj 0.353 0.353 0.349 rg 0.0062 Tc -22.108 -1.088 Td (pe)Tj 0.247 0.247 0.243 rg -0.035 Tc 9.1875 0 0 9.7 54.71 608.89 Tm (ri)Tj 0.353 0.353 0.349 rg 0.004 Tc 9.7 0 0 9.7 60.46 608.89 Tm (vasc)Tj 0.247 0.247 0.243 rg -0.0061 Tc 1.833 0 Td (ular )Tj 0.0312 Tc 1.921 0 Td (cuff)Tj 0.353 0.353 0.349 rg 0.0025 Tc 1.578 0 Td (s; )Tj 0.247 0.247 0.243 rg -0.005 Tc 1.102 0 Td (wid)Tj 0.353 0.353 0.349 rg 0 Tc 1.475 0 Td (e)Tj 0.247 0.247 0.243 rg -0.0183 Tc 0.504 0 Td (nin)Tj 0.353 0.353 0.349 rg 0 Tc 1.279 0 Td (g )Tj 0.05 Tc 10.5727 0 0 9.7 162.62 608.89 Tm (of )Tj -0.015 Tc 9.7 0 0 9.7 175.06 608.89 Tm (sc)Tj 0.169 0.169 0.165 rg 0 Tc 0.847 0 Td (i)Tj 0.353 0.353 0.349 rg 0.039 Tc 0.241 0 Td (ss)Tj 0.247 0.247 0.243 rg -0.035 Tc 9.6313 0 0 9.7 193.92 608.89 Tm (ur)Tj 0.353 0.353 0.349 rg -0.0316 Tc 9.7 0 0 9.7 201.5 608.89 Tm (ae; )Tj 0 Tc 1.48 0 Td (s)Tj 0.247 0.247 0.243 rg 0.509 0 Td (u)Tj 0.353 0.353 0.349 rg -0.035 Tc 9.5458 0 0 9.7 225.61 608.89 Tm (bp)Tj 0.247 0.247 0.243 rg 0 Tc 9.7 0 0 9.7 235.6 608.89 Tm (l)Tj 0.353 0.353 0.349 rg 0.196 0 Td (e)Tj 0.247 0.247 0.243 rg 0.505 0 Td (u)Tj 0.353 0.353 0.349 rg -0.0334 Tc 0.494 0 Td (ra)Tj 0.247 0.247 0.243 rg 0 Tc 0.735 0 Td (l )Tj -0.0232 Tc 0.691 0 Td (and )Tj 0.353 0.353 0.349 rg 0 Tc -22.216 -1.138 Td (i)Tj 0.247 0.247 0.243 rg -0.009 Tc 0.304 0 Td (ntr)Tj 0.353 0.353 0.349 rg 0 Tc 1.079 0 Td (a)Tj 0.247 0.247 0.243 rg -0.0257 Tc 0.457 0 Td (pl)Tj 0.353 0.353 0.349 rg 0 Tc 0.78 0 Td (e)Tj 0.247 0.247 0.243 rg -0.0061 Tc 0.505 0 Td (ural )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0146 Tc 9.7 0 0 9.7 94.9403 597.8514 Tm (erfu)Tj 0.353 0.353 0.349 rg 0 Tc 1.678 0 Td (s)Tj 0.247 0.247 0.243 rg 0.0129 Tc 0.353 0 Td (ion)Tj 0.353 0.353 0.349 rg 0 Tc 1.373 0 Td (; )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0113 Tc 9.7 0 0 9.7 134.3126 597.8514 Tm (diffu)Tj 0.353 0.353 0.349 rg 0.05 Tc 10.0847 0 0 9.7 153.46 597.85 Tm (se )Tj 0.169 0.169 0.165 rg -0.035 Tc 9.2582 0 0 9.7 166.48 597.85 Tm (in)Tj 0.353 0.353 0.349 rg 0 Tc 9.7 0 0 9.7 173.67 597.85 Tm (c)Tj 0.247 0.247 0.243 rg 0.503 0 Td (r)Tj 0.353 0.353 0.349 rg 0.0442 Tc 0.288 0 Td (ease )Tj 0.05 Tc 10.5727 0 0 9.7 202.46 597.85 Tm (of )Tj 0.247 0.247 0.243 rg 0 Tc 9.7 0 0 9.7 213.99 597.85 Tm (d)Tj 0.353 0.353 0.349 rg 0.543 0 Td (e)Tj 0.247 0.247 0.243 rg 0.504 0 Td (n)Tj 0.353 0.353 0.349 rg 0.432 0 Td (s)Tj 0.247 0.247 0.243 rg -0.0241 Tc 0.501 0 Td (ity )Tj 0.353 0.353 0.349 rg -0.0212 Tc 1.481 0 Td (\(27])Tj 0.247 0.247 0.243 rg 0 Tc 1.673 0 Td (. )Tj ET BT /Suspect <>BDC 0.353 0.353 0.349 rg /T1_1 1 Tf 9.9 0 0 9.9 44.92 586.8 Tm (G)Tj 0.247 0.247 0.243 rg 0.741 0 Td (r)Tj 0.353 0.353 0.349 rg 0.386 0 Td (o)Tj 0.247 0.247 0.243 rg 0.533 0 Td (u)Tj 0.353 0.353 0.349 rg 0.478 0 Td (p )Tj EMC ET BT /T1_0 1 Tf 0.0112 Tc 9.7 0 0 9.7 76.74 586.8 Tm (2. )Tj ET BT /Suspect <>BDC 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0153 Tc 9.7 0 0 9.7 89.7186 586.8 Tm (Pati)Tj 0.353 0.353 0.349 rg 0 Tc 1.627 0 Td (e)Tj 0.247 0.247 0.243 rg 0.0125 Tc 0.504 0 Td (nts )Tj EMC /Suspect <>BDC 0.0033 Tc 1.781 0 Td (with )Tj EMC /Suspect <>BDC 0.0118 Tc 2.424 0 Td (ARD)Tj 0.353 0.353 0.349 rg 0 Tc 2.111 0 Td (S )Tj EMC ET BT /T1_0 1 Tf 9.7 0 0 9.7 183.246 586.8 Tm (\()Tj 0.247 0.247 0.243 rg 0.357 0 Td (n)Tj 0.353 0.353 0.349 rg 0.491 0 Td (=)Tj 0.247 0.247 0.243 rg 0.589 0 Td (7)Tj 0.353 0.353 0.349 rg 0.499 0 Td (\))Tj 0.247 0.247 0.243 rg 0.381 0 Td (. )Tj 0.0446 Tc 0.804 0 Td (Th)Tj 0.353 0.353 0.349 rg 0.0157 Tc 1.186 0 Td (ese )Tj 0.247 0.247 0.243 rg -0.0012 Tc 1.892 0 Td (pati)Tj 0.353 0.353 0.349 rg 0 Tc 1.523 0 Td (e)Tj 0.247 0.247 0.243 rg 0.455 0 Td (n)Tj 0.353 0.353 0.349 rg -0.0204 Tc 0.543 0 Td (ts )Tj 0.0271 Tc -22.96 -1.138 Td (we)Tj 0.169 0.169 0.165 rg 0 Tc 1.188 0 Td (r)Tj 0.353 0.353 0.349 rg 0.337 0 Td (e )Tj 0.0345 Tc 0.837 0 Td (se)Tj 0.169 0.169 0.165 rg 0 Tc 0.897 0 Td (l)Tj 0.353 0.353 0.349 rg 0.0245 Tc 0.245 0 Td (ec)Tj 0.247 0.247 0.243 rg -0.015 Tc 0.948 0 Td (ted )Tj -0.035 Tc 9.4567 0 0 9.7 104.64 575.76 Tm (up)Tj 0.353 0.353 0.349 rg 0 Tc 9.7 0 0 9.7 114.15 575.76 Tm (o)Tj 0.169 0.169 0.165 rg 0.503 0 Td (n )Tj 0.247 0.247 0.243 rg 0.0143 Tc 0.881 0 Td (admi)Tj 0.353 0.353 0.349 rg 0.039 Tc 2.074 0 Td (ss)Tj 0.247 0.247 0.243 rg -0.0119 Tc 0.847 0 Td (ion )Tj 0.169 0.169 0.165 rg 0 Tc 1.738 0 Td (t)Tj 0.353 0.353 0.349 rg 0.191 0 Td (o )Tj 0.247 0.247 0.243 rg -0.0324 Tc 0.947 0 Td (th)Tj 0.353 0.353 0.349 rg 0 Tc 0.783 0 Td [(e )-149(i)]TJ 0.247 0.247 0.243 rg -0.0314 Tc 1.147 0 Td (nt)Tj 0.353 0.353 0.349 rg 0 Tc 0.733 0 Td (e)Tj 0.169 0.169 0.165 rg 0.455 0 Td (n)Tj 0.353 0.353 0.349 rg 0.531 0 Td (s)Tj 0.247 0.247 0.243 rg 0.452 0 Td (i)Tj 0.353 0.353 0.349 rg 0.05 Tc 9.7216 0 0 9.7 226.06 575.76 Tm (ve )Tj 0 Tc 9.7 0 0 9.7 238.47 575.76 Tm (c)Tj 0.247 0.247 0.243 rg 0.0268 Tc 0.494 0 Td (ar)Tj 0.353 0.353 0.349 rg 0 Tc 0.792 0 Td (e )Tj 0.247 0.247 0.243 rg 0.01 Tc 0.901 0 Td (unit )Tj 0.353 0.353 0.349 rg 0 Tc -22.129 -1.137 Td (o)Tj 0.247 0.247 0.243 rg 0.542 0 Td (f )Tj 0.05 Tc 9.8542 0 0 9.7 57.51 564.73 Tm (our )Tj 0 Tc 9.7 0 0 9.7 75.83 564.73 Tm (h)Tj 0.353 0.353 0.349 rg 0.0221 Tc 0.487 0 Td (os)Tj 0.247 0.247 0.243 rg 0.0165 Tc 0.901 0 Td (pital)Tj 0.353 0.353 0.349 rg 0 Tc 1.864 0 Td (, )Tj 0.247 0.247 0.243 rg 0.698 0 Td (a)Tj 0.353 0.353 0.349 rg 0.0346 Tc 0.446 0 Td (cco)Tj 0.247 0.247 0.243 rg -0.0087 Tc 1.493 0 Td (rdin)Tj 0.353 0.353 0.349 rg 0 Tc 1.626 0 Td (g )Tj 0.247 0.247 0.243 rg 0.996 0 Td (t)Tj 0.353 0.353 0.349 rg 0.29 0 Td (o )Tj 0.169 0.169 0.165 rg -0.035 Tc 9.0854 0 0 9.7 170.86 564.73 Tm (th)Tj 0.353 0.353 0.349 rg 0 Tc 9.7 0 0 9.7 178.46 564.73 Tm (e )Tj 0.247 0.247 0.243 rg 0.939 0 Td (f)Tj 0.353 0.353 0.349 rg 0.299 0 Td (o)Tj 0.247 0.247 0.243 rg -0.035 Tc 9.5285 0 0 9.7 195.76 564.73 Tm (ll)Tj 0.353 0.353 0.349 rg 0.0277 Tc 9.7 0 0 9.7 201.03 564.73 Tm (owi)Tj 0.169 0.169 0.165 rg 0 Tc 1.542 0 Td (n)Tj 0.353 0.353 0.349 rg 0.488 0 Td [(g )-239(c)]TJ 0.247 0.247 0.243 rg -0.0227 Tc 1.492 0 Td (rit)Tj 0.353 0.353 0.349 rg 0 Tc 0.881 0 Td (e)Tj 0.247 0.247 0.243 rg 0.018 Tc 0.455 0 Td (ria)Tj 0.353 0.353 0.349 rg 0 Tc 1.064 0 Td (: )Tj ET BT /Suspect <>BDC 0.169 0.169 0.165 rg /T1_0 1 Tf 9.7 0 0 9.7 267.2907 564.73 Tm (I)Tj 0.353 0.353 0.349 rg 0.298 0 Td (\) )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0008 Tc 9.7 0 0 9.7 45.0249 553.6817 Tm (arterial )Tj 0.0329 Tc 3.366 0 Td (oxyg)Tj 0.353 0.353 0.349 rg 0 Tc 2.077 0 Td (e)Tj 0.169 0.169 0.165 rg 0.504 0 Td [(n )-239(t)]TJ 0.353 0.353 0.349 rg 1.228 0 Td (e)Tj 0.247 0.247 0.243 rg 0.455 0 Td (n)Tj 0.353 0.353 0.349 rg 0.531 0 Td (s)Tj 0.247 0.247 0.243 rg -0.035 Tc 9.6738 0 0 9.7 128.56 553.68 Tm (ion )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0362 Tc 9.7 0 0 9.7 145.33 553.68 Tm (\(Pa)Tj 0.353 0.353 0.349 rg 0.0378 Tc 1.388 0 Td (o,\) )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 0.05 Tc 10.5727 0 0 9.7 174.62 553.68 Tm (of )Tj 0.353 0.353 0.349 rg 0.0143 Tc 9.7 0 0 9.7 187.58 553.68 Tm (75 )Tj 0.169 0.169 0.165 rg /T1_1 1 Tf 0.05 Tc 10.5588 0 0 9.9 202.03 553.68 Tm (mmR)Tj 0.353 0.353 0.349 rg 0 Tc 9.9 0 0 9.9 224.72 553.68 Tm (g )Tj 0.247 0.247 0.243 rg /T1_0 1 Tf 0.05 Tc 10.0163 0 0 9.7 234.14 553.68 Tm (or )Tj 0.169 0.169 0.165 rg 0 Tc 9.7 0 0 9.7 247.6 553.68 Tm (l)Tj 0.353 0.353 0.349 rg 0.0179 Tc 0.245 0 Td (ess )Tj ET BT /Suspect <>BDC 0.247 0.247 0.243 rg /T1_0 1 Tf 0.05 Tc 9.4869 0 0 9.1 266.78 553.68 Tm (at )Tj EMC ET BT /T1_0 1 Tf 0.0083 Tc 9.7 0 0 9.7 44.54 543.12 Tm (an )Tj -0.035 Tc 9.2582 0 0 9.7 59.44 543.12 Tm (in)Tj 0.353 0.353 0.349 rg 0 Tc 9.7 0 0 9.7 66.58 543.12 Tm (s)Tj 0.247 0.247 0.243 rg 0.0186 Tc 0.411 0 Td (pir)Tj 0.353 0.353 0.349 rg 0 Tc 1.127 0 Td (e)Tj 0.247 0.247 0.243 rg 0.446 0 Td [(d )-289(o)]TJ 0.353 0.353 0.349 rg -0.0018 Tc 1.59 0 Td (xyge)Tj 0.247 0.247 0.243 rg 0 Tc 1.981 0 Td (n )Tj -0.035 Tc 9.5971 0 0 9.7 129.97 543.12 Tm (fr)Tj 0.353 0.353 0.349 rg 0.05 Tc 9.8601 0 0 9.7 136.22 543.12 Tm (ac)Tj 0.247 0.247 0.243 rg -0.0073 Tc 9.7 0 0 9.7 145.42 543.12 Tm (ti)Tj 0.353 0.353 0.349 rg 0 Tc 0.537 0 Td (o)Tj 0.247 0.247 0.243 rg 0.553 0 Td (n )Tj 0.353 0.353 0.349 rg 0.981 0 Td (o)Tj 0.169 0.169 0.165 rg 0.542 0 Td (f )Tj 0.353 0.353 0.349 rg 0.793 0 Td (a)Tj 0.247 0.247 0.243 rg 0.454 0 Td (t )Tj 0.169 0.169 0.165 rg 0.786 0 Td (l)Tj 0.353 0.353 0.349 rg 0.0157 Tc 0.245 0 Td (eas)Tj 0.247 0.247 0.243 rg 0 Tc 1.344 0 Td (t )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.026 Tc 9.7 0 0 9.7 212.544 543.12 Tm (0.4; )Tj EMC ET BT 0.353 0.353 0.349 rg /T1_0 1 Tf 0.0271 Tc 9.7 0 0 9.7 232.7394 543.12 Tm (2\) )Tj 0 Tc 1.328 0 Td (s)Tj 0.247 0.247 0.243 rg -0.0074 Tc 0.46 0 Td (udd)Tj 0.353 0.353 0.349 rg 0 Tc 1.474 0 Td (e)Tj 0.247 0.247 0.243 rg 0.504 0 Td (n )Tj 0.353 0.353 0.349 rg -23.167 -1.137 Td (o)Tj 0.247 0.247 0.243 rg 0.553 0 Td (n)Tj 0.353 0.353 0.349 rg -0.015 Tc 0.531 0 Td (se)Tj 0.169 0.169 0.165 rg 0 Tc 0.854 0 Td (t )Tj 0.353 0.353 0.349 rg 0.735 0 Td (o)Tj 0.247 0.247 0.243 rg 0.592 0 Td (f )Tj -0.0026 Tc 0.804 0 Td (bil)Tj 0.353 0.353 0.349 rg 0 Tc 1.077 0 Td (a)Tj 0.247 0.247 0.243 rg 0.503 0 Td (t)Tj 0.353 0.353 0.349 rg 0.239 0 Td (e)Tj 0.247 0.247 0.243 rg 0.504 0 Td (r)Tj 0.353 0.353 0.349 rg 0.288 0 Td (a)Tj 0.169 0.169 0.165 rg 0.447 0 Td (l )Tj 0.247 0.247 0.243 rg 0.0113 Tc 0.841 0 Td (infiltrat)Tj 0.353 0.353 0.349 rg 0.029 Tc 3.066 0 Td (es )Tj 0 Tc 1.337 0 Td (o)Tj 0.169 0.169 0.165 rg 0.553 0 Td (n )Tj 0.353 0.353 0.349 rg 0.981 0 Td (c)Tj 0.247 0.247 0.243 rg 0.503 0 Td (h)Tj 0.353 0.353 0.349 rg 0.029 Tc 0.486 0 Td (es)Tj 0.169 0.169 0.165 rg 0 Tc 0.899 0 Td (t )Tj 0.353 0.353 0.349 rg -0.035 Tc 9.4645 0 0 9.7 204.94 532.09 Tm (X-)Tj 0.247 0.247 0.243 rg 0.0055 Tc 9.7 0 0 9.7 215.51 532.09 Tm (ray)Tj 0.353 0.353 0.349 rg 0 Tc 1.316 0 Td [(; )-223(3)]TJ 0.247 0.247 0.243 rg [(\) )-254(a )]TJ ET BT /Suspect <>BDC /T1_0 1 Tf 0.0098 Tc 9.7 0 0 9.7 258.2482 532.09 Tm (pre)Tj 0.353 0.353 0.349 rg 0 Tc 1.324 0 Td (\255)Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 0.017 Tc 9.7 0 0 9.7 44.5475 521.0514 Tm (disposing )Tj 0.0132 Tc 4.355 0 Td (condition )Tj 0.169 0.169 0.165 rg 0.0171 Tc 4.263 0 Td (to )Tj ET BT /Suspect <>BDC 0.247 0.247 0.243 rg /T1_0 1 Tf 0.004 Tc 9.7 0 0 9.7 139.6657 521.0514 Tm (ARDS )Tj EMC /Suspect <>BDC 0 Tc 3.16 0 Td (d)Tj 0.353 0.353 0.349 rg 0.494 0 Td (e)Tj 0.247 0.247 0.243 rg 0.503 0 Td (v)Tj 0.353 0.353 0.349 rg 0.437 0 Td (e)Tj 0.247 0.247 0.243 rg -0.0033 Tc 0.497 0 Td (lopm)Tj 0.353 0.353 0.349 rg 0 Tc 2.076 0 Td (e)Tj 0.247 0.247 0.243 rg -0.0305 Tc 0.504 0 Td (nt; )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 227.9648 521.0514 Tm (4)Tj 0.353 0.353 0.349 rg 0.493 0 Td (\) )Tj 0.247 0.247 0.243 rg 0.797 0 Td (n)Tj 0.353 0.353 0.349 rg 0.487 0 Td (o )Tj 0.247 0.247 0.243 rg 0.015 Tc 0.841 0 Td (oth)Tj 0.353 0.353 0.349 rg 0 Tc 1.335 0 Td (e)Tj 0.247 0.247 0.243 rg 0.504 0 Td (r )Tj 0.016 Tc -23.366 -1.139 Td (explanation )Tj 0.169 0.169 0.165 rg 0.0171 Tc 5.254 0 Td (to )Tj 0.0097 Tc 1.188 0 Td (the )Tj 0.247 0.247 0.243 rg 0.0248 Tc 1.625 0 Td (above )Tj 0.169 0.169 0.165 rg 0 Tc 2.82 0 Td (f)Tj 0.071 0.071 0.067 rg 0.399 0 Td (i)Tj 0.169 0.169 0.165 rg 0.0026 Tc 0.255 0 Td (ndin)Tj 0.353 0.353 0.349 rg -0.0066 Tc 1.824 0 Td (gs; )Tj 0.0424 Tc 1.578 0 Td (5\) )Tj 0.247 0.247 0.243 rg 0.0333 Tc 1.24 0 Td (at )Tj 0.169 0.169 0.165 rg -0.0324 Tc 1.196 0 Td (th)Tj 0.353 0.353 0.349 rg 0 Tc 0.734 0 Td (e )Tj 0.247 0.247 0.243 rg -0.021 Tc 0.899 0 Td (tim)Tj 0.353 0.353 0.349 rg 0 Tc 1.328 0 Td (e )Tj 0.247 0.247 0.243 rg 0.05 Tc 10.5727 0 0 9.7 249.98 510 Tm (of )Tj -0.035 Tc 9.0854 0 0 9.7 262.54 510 Tm (th)Tj 0.353 0.353 0.349 rg 0 Tc 9.7 0 0 9.7 269.66 510 Tm (e )Tj 0.247 0.247 0.243 rg 0.0091 Tc -23.212 -1.137 Td (study )Tj 0.0171 Tc 2.737 0 Td (patients )Tj 0.169 0.169 0.165 rg -0.0048 Tc 3.759 0 Td (no. )Tj 0 Tc 1.873 0 Td (l )Tj 0.0263 Tc 0.938 0 Td (and )Tj 0 Tc 1.977 0 Td (6 )Tj -0.002 Tc 1.051 0 Td (had )Tj 0.353 0.353 0.349 rg 0 Tc 1.966 0 Td (s)Tj 0.169 0.169 0.165 rg 0.507 0 Td (t)Tj 0.353 0.353 0.349 rg 0.191 0 Td (o)Tj 0.247 0.247 0.243 rg 0.0482 Tc 0.555 0 Td (pp)Tj 0.353 0.353 0.349 rg -0.0325 Tc 1.028 0 Td (ed )Tj 0 Tc 1.48 0 Td (s)Tj 0.247 0.247 0.243 rg 0.408 0 Td (m)Tj 0.353 0.353 0.349 rg 0.785 0 Td (o)Tj 0.247 0.247 0.243 rg -0.0195 Tc 0.552 0 Td (kin)Tj 0.353 0.353 0.349 rg 0 Tc 1.28 0 Td (g )Tj 0.169 0.169 0.165 rg -0.007 Tc 1.045 0 Td (tw)Tj 0.353 0.353 0.349 rg 0 Tc 0.982 0 Td (o )Tj 0.247 0.247 0.243 rg 0.0202 Tc -23.101 -1.089 Td (weeks )Tj 0.0259 Tc 3.158 0 Td (earlie)Tj 0.071 0.071 0.067 rg 0 Tc 2.335 0 Td (r)Tj 0.169 0.169 0.165 rg 0.376 0 Td (. )Tj ET BT /Suspect <>BDC 0.247 0.247 0.243 rg /T1_0 1 Tf 0.017 Tc 9.7 0 0 9.7 109.3966 488.4078 Tm (Patients )Tj EMC ET BT 0.169 0.169 0.165 rg /T1_0 1 Tf 0.0143 Tc 9.7 0 0 9.7 147.828 488.4078 Tm (were )Tj 0.247 0.247 0.243 rg 0.0178 Tc 2.625 0 Td (br)Tj 0.353 0.353 0.349 rg 0.0245 Tc 0.83 0 Td (ea)Tj 0.247 0.247 0.243 rg -0.0059 Tc 0.948 0 Td (thin)Tj 0.353 0.353 0.349 rg 0 Tc 1.577 0 Td [(g )-382(s)]TJ 0.247 0.247 0.243 rg 1.543 0 Td (p)Tj 0.353 0.353 0.349 rg 0.485 0 Td (o)Tj 0.247 0.247 0.243 rg -0.0114 Tc 0.553 0 Td (ntan)Tj 0.353 0.353 0.349 rg 0 Tc 1.723 0 Td (e)Tj 0.247 0.247 0.243 rg 0.0101 Tc 0.496 0 Td (ou)Tj 0.353 0.353 0.349 rg 0 Tc 1.034 0 Td (s)Tj 0.247 0.247 0.243 rg -0.0195 Tc 0.402 0 Td (ly )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0197 Tc 9.7 0 0 9.7 44.6297 477.3692 Tm (without )Tj EMC ET BT /T1_0 1 Tf 0.0165 Tc 9.7 0 0 9.7 82.0911 477.3692 Tm (being )Tj 0.0175 Tc 3.007 0 Td (endotracheally )Tj 0.169 0.169 0.165 rg 0.0199 Tc 6.781 0 Td (intubated )Tj 0.247 0.247 0.243 rg 0.0286 Tc 4.601 0 Td (or )Tj 0.169 0.169 0.165 rg 0.0118 Tc 1.542 0 Td (receiving )Tj ET BT /Suspect <>BDC 0.247 0.247 0.243 rg /T1_0 1 Tf 0.014 Tc 9.7 0 0 9.7 44.1156 466.3306 Tm (PEEP. )Tj EMC ET BT /T1_0 1 Tf 0.0082 Tc 9.7 0 0 9.7 74.3796 466.3306 Tm (All )Tj 0.169 0.169 0.165 rg 0.0195 Tc 1.682 0 Td (these )Tj 0.247 0.247 0.243 rg 0.0123 Tc 2.514 0 Td (features )Tj 0.169 0.169 0.165 rg -0.002 Tc 3.672 0 Td (had )Tj 0.247 0.247 0.243 rg 0.0171 Tc 1.879 0 Td (to )Tj 0.05 Tc 9.7621 0 0 9.6 180.49 466.33 Tm (be )Tj 0.0238 Tc 9.7 0 0 9.7 193.45 466.33 Tm (present )Tj -0.0162 Tc 3.403 0 Td (at )Tj 0.0097 Tc 1.146 0 Td (the )Tj 0.0172 Tc 1.621 0 Td (same )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0106 Tc 9.7 0 0 9.7 44.6229 455.757 Tm (time. )Tj EMC ET BT /T1_0 1 Tf -0.0165 Tc 9.7 0 0 9.7 70.5413 455.757 Tm (All )Tj 0.169 0.169 0.165 rg 0.0345 Tc 1.88 0 Td (the )Tj 0.353 0.353 0.349 rg 0 Tc 1.819 0 Td (s)Tj 0.247 0.247 0.243 rg 0.0189 Tc 0.4 0 Td (elected )Tj 0.01 Tc 3.525 0 Td (patients )Tj 0 Tc 3.808 0 Td (w)Tj 0.353 0.353 0.349 rg 0.684 0 Td (e)Tj 0.247 0.247 0.243 rg 0.05 Tc 9.8826 0 0 9.7 192.47 455.76 Tm (re )Tj 0.0102 Tc 9.7 0 0 9.7 206.3 455.76 Tm (able )Tj 0.0171 Tc 2.285 0 Td (to )Tj 0.0093 Tc 1.339 0 Td (perform )Tj 0.169 0.169 0.165 rg 0.0088 Tc -20.292 -1.138 Td (three )Tj 0.0171 Tc 2.474 0 Td (to )Tj 0.247 0.247 0.243 rg -0.0013 Tc 1.175 0 Td (six )Tj 0.0224 Tc 1.633 0 Td (slow )Tj 0.169 0.169 0.165 rg 0.0141 Tc 2.381 0 Td (inspiratory )Tj 0.247 0.247 0.243 rg 0.0032 Tc 4.905 0 Td (vital )Tj 0.0155 Tc 2.22 0 Td (capacity )Tj 0.0139 Tc 3.867 0 Td (manoeuvres )Tj 0.0203 Tc -18.664 -1.137 Td (as )Tj 0.169 0.169 0.165 rg 0.0164 Tc 1.296 0 Td (requested )Tj 0.247 0.247 0.243 rg -0.0007 Tc 4.456 0 Td (by )Tj 0.169 0.169 0.165 rg 0.0097 Tc 1.531 0 Td (the )Tj 0.0039 Tc 1.732 0 Td (method. )Tj 0.247 0.247 0.243 rg 0.0297 Tc 3.804 0 Td (Table )Tj 0.169 0.169 0.165 rg 0 Tc 2.97 0 Td (I )Tj 0.247 0.247 0.243 rg 0.0305 Tc 0.834 0 Td (show)Tj 0.353 0.353 0.349 rg 0 Tc 2.177 0 Td (s )Tj 0.247 0.247 0.243 rg -0.015 Tc 0.953 0 Td (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0082 Tc 9.7 0 0 9.7 252.3847 433.6925 Tm (clini\255)Tj EMC ET BT /T1_0 1 Tf 0.0223 Tc 9.7 0 0 9.7 44.0675 422.6539 Tm (cal )Tj 0.0052 Tc 1.581 0 Td (features )Tj 0.05 Tc 10.5727 0 0 9.7 94.46 422.65 Tm (of )Tj 0.169 0.169 0.165 rg -0.015 Tc 9.7 0 0 9.7 107.02 422.65 Tm (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.004 Tc 9.7 0 0 9.7 122.3848 422.65 Tm (ARDS )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0029 Tc 9.7 0 0 9.7 152.6585 422.65 Tm (patients )Tj 0.016 Tc 3.502 0 Td (enrolled )Tj -0.0186 Tc 3.763 0 Td (in )Tj 0.0097 Tc 1.194 0 Td (the )Tj 0.0068 Tc 1.571 0 Td (study. )Tj /T1_1 1 Tf 9.9 0 0 9.9 43.96 412.09 Tm (Group )Tj 0 Tc 3.066 0 Td (3)Tj 0.071 0.071 0.067 rg 0.581 0 Td (. )Tj 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0186 Tc 9.7 0 0 9.7 86.32 412.09 Tm (Thirty-five )Tj 0.169 0.169 0.165 rg 5.005 0 Td (normal )Tj 0.247 0.247 0.243 rg 0.015 Tc 3.352 0 Td (subjects, )Tj 0.0183 Tc 4.012 0 Td (aged )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0171 Tc 10.3 0 0 10.3 230.52 412.09 Tm (18-50 )Tj EMC ET BT /T1_0 1 Tf -0.0112 Tc 9.7 0 0 9.7 259.19 412.09 Tm (yrs, )Tj 0.0086 Tc -22.174 -1.089 Td (25 )Tj 0.071 0.071 0.067 rg 0 Tc 1.736 0 Td (m)Tj 0.247 0.247 0.243 rg 0.0142 Tc 0.783 0 Td (ales )Tj 0 Tc 2.326 0 Td (a)Tj 0.071 0.071 0.067 rg 0.504 0 Td (n)Tj 0.247 0.247 0.243 rg 0.487 0 Td (d )Tj ET BT /Suspect <>BDC 0.169 0.169 0.165 rg /T1_0 1 Tf 0.0116 Tc 9.7 0 0 9.7 113.4184 401.5267 Tm (10 )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0057 Tc 9.7 0 0 9.7 129.9666 401.5267 Tm (females, )Tj 0.0086 Tc 4.162 0 Td (22 )Tj 0.169 0.169 0.165 rg 0.0134 Tc 1.737 0 Td (nonsmokers )Tj 0.0016 Tc 5.681 0 Td (and )Tj 0.247 0.247 0.243 rg -0.035 Tc 9.6688 0 0 9.7 264.15 401.53 Tm (13 )Tj 0.0181 Tc 9.7 0 0 9.7 44.02 390.49 Tm (smokers )Tj 0.0382 Tc 4.011 0 Td (\(>I )Tj 0.0011 Tc 1.992 0 Td (pack )Tj 0.0098 Tc 2.474 0 Td (per )Tj 0.0253 Tc 1.821 0 Td (day )Tj 0.0012 Tc 2.076 0 Td (for )Tj 0.0264 Tc 1.692 0 Td (more )Tj 0.0048 Tc 2.672 0 Td (than )Tj -0.0061 Tc 2.375 0 Td (two )Tj 0.0073 Tc 2.03 0 Td (years\) )Tj 0.0143 Tc -21.13 -1.089 Td (were )Tj 0.0263 Tc 2.609 0 Td (studied )Tj 0.169 0.169 0.165 rg 0.0203 Tc 3.666 0 Td (as )Tj ET BT /Suspect <>BDC 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0097 Tc 9.7 0 0 9.7 119.971 379.9267 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.01 Tc 9.7 0 0 9.7 138.1391 379.9267 Tm (control )Tj 0.0109 Tc 3.564 0 Td (group. )Tj 0.169 0.169 0.165 rg 0.0131 Tc 3.278 0 Td (Normal )Tj 0.247 0.247 0.243 rg 0.0145 Tc 3.797 0 Td (clinical)Tj 0.353 0.353 0.349 rg 0 Tc 3.111 0 Td (, )Tj 0.247 0.247 0.243 rg 0.0097 Tc -23.452 -1.138 Td (functional )Tj 0.0263 Tc 4.653 0 Td (and )Tj 0.169 0.169 0.165 rg 0.0118 Tc 1.989 0 Td (radiological )Tj 0.247 0.247 0.243 rg 0.0251 Tc 5.38 0 Td (status )Tj -0.0078 Tc 2.884 0 Td (was )Tj 0.0102 Tc 2.078 0 Td (requested )Tj 0.169 0.169 0.165 rg -0.0324 Tc 4.453 0 Td (to )Tj 0.247 0.247 0.243 rg /T1_2 1 Tf -0.0135 Tc 9 0 0 9 263.83 368.89 Tm (be )Tj /T1_0 1 Tf 0.0256 Tc 9.7 0 0 9.7 43.58 357.84 Tm (admitted )Tj -0.0324 Tc 4.066 0 Td (to )Tj ET BT /Suspect <>BDC 0.169 0.169 0.165 rg /T1_0 1 Tf 0.0097 Tc 9.7 0 0 9.7 94.5438 357.84 Tm (the )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0068 Tc 9.7 0 0 9.7 110.2675 357.84 Tm (study. )Tj /T1_1 1 Tf 0.0161 Tc 9.9 0 0 9.9 43.35 326.65 Tm (Aerosol )Tj 0.0076 Tc 3.532 0 Td (generation )Tj 0.169 0.169 0.165 rg 0.0302 Tc 4.786 0 Td (and )Tj 0.247 0.247 0.243 rg 0.0094 Tc 1.892 0 Td (delivery )Tj 0.0203 Tc -10.218 -2.474 Td (Radionuclide. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0154 Tc 6.3001 0 0 6.3001 106.97 305.05 Tm (99)Tj 0.0225 Tc 9.7 0 0 9.7 113.1 302.16 Tm ("'Technetium, )Tj EMC ET BT /T1_0 1 Tf 0.0296 Tc 9.7 0 0 9.7 176.0724 302.16 Tm (chelated )Tj 0.0171 Tc 4.164 0 Td (to )Tj 0.0281 Tc 1.378 0 Td (diethylene )Tj 0.169 0.169 0.165 rg 0.0128 Tc -19.193 -1.138 Td (triamine )Tj 0.247 0.247 0.243 rg 0.0172 Tc 3.962 0 Td (pentacetate )Tj 0.0117 Tc 5.184 0 Td (\(DTPA\) )Tj 0.017 Tc 3.92 0 Td (was )Tj 0.0075 Tc 2.121 0 Td (inhaled )Tj 0.0203 Tc 3.511 0 Td (as )Tj 0.0083 Tc 1.386 0 Td (an )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0094 Tc 9.7 0 0 9.7 252.877 291.1214 Tm (aero\255)Tj EMC ET BT /T1_0 1 Tf -0.0013 Tc 9.7 0 0 9.7 43.5607 280.5581 Tm (sol )Tj 0.0176 Tc 1.59 0 Td (generated )Tj 0.0198 Tc 4.461 0 Td (with )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.2126 0 0 9.7 123.8 280.56 Tm (ROm..E )Tj EMC ET BT /T1_0 1 Tf 0.0193 Tc 9.7 0 0 9.7 153.02 280.56 Tm (apparatu)Tj 0.353 0.353 0.349 rg 0 Tc 3.608 0 Td (s )Tj 0.247 0.247 0.243 rg 0.832 0 Td ([28], )Tj -0.0032 Tc 2.398 0 Td (which )Tj 0.015 Tc 2.861 0 Td (allows )Tj 0.0097 Tc -20.973 -1.137 Td (the )Tj 0.0144 Tc 1.775 0 Td (inhalation )Tj 0.05 Tc 10.5727 0 0 9.7 105.98 269.53 Tm (of )Tj 0 Tc 9.7 0 0 9.7 119.42 269.53 Tm (a )Tj 0.017 Tc 1.047 0 Td (monodisp)Tj 0.353 0.353 0.349 rg 0 Tc 4.099 0 Td (e)Tj 0.169 0.169 0.165 rg 0.0059 Tc 0.455 0 Td (rsed )Tj 0.247 0.247 0.243 rg 0.0055 Tc 2.276 0 Td (radioaerosol )Tj 0.0158 Tc 5.581 0 Td (\(mass )Tj 0.0067 Tc -21.269 -1.138 Td (median )Tj 0.169 0.169 0.165 rg 0.0095 Tc 3.655 0 Td (diameter, )Tj ET BT /Suspect <>BDC 0.247 0.247 0.243 rg /T1_0 1 Tf -0.0317 Tc 10.3 0 0 10.3 122.29 258.49 Tm (0.8 )Tj EMC /Suspect <>BDC 0.169 0.169 0.165 rg -0.035 Tc 7.4858 0 0 9.8 141.07 258.49 Tm (IJlTl )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0263 Tc 9.7 0 0 9.7 160.7 258.49 Tm (and )Tj 0.003 Tc 2.082 0 Td (2.4 )Tj 0.0161 Tc 1.928 0 Td (geometric )Tj 0 Tc 4.744 0 Td (s)Tj 0.353 0.353 0.349 rg 0.401 0 Td (o)Tj 0.247 0.247 0.243 rg -0.0198 Tc 0.498 0 Td (\). )Tj 0 Tc 1.241 0 Td (A )Tj -22.97 -1.089 Td (3 )Tj -0.0104 Tc 0.949 0 Td (ml )Tj 0.0242 Tc 1.522 0 Td (saline )Tj 0.0172 Tc 2.87 0 Td (solution )Tj 0.05 Tc 10.5727 0 0 9.7 131.9 247.93 Tm (of )Tj /T1_1 1 Tf 0 Tc 6.4001 0 0 6.4001 144.91 250.8 Tm (9)Tj -0.035 Tc 9.7478 0 0 10.2 147.76 247.93 Tm (9mTc-DTP )Tj 0.169 0.169 0.165 rg /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 189.1 247.93 Tm (A )Tj 0.247 0.247 0.243 rg -0.0132 Tc 1.189 0 Td (with )Tj 0.169 0.169 0.165 rg 0 Tc 2.218 0 Td (a )Tj 0.247 0.247 0.243 rg 0.0177 Tc 0.892 0 Td (concentra-)Tj /T1_2 1 Tf 0.0201 Tc 8.6 0 0 8.6 43.14 215.76 Tm (Table )Tj 0.169 0.169 0.165 rg -0.0198 Tc 3.1 0 Td (1. )Tj 0.247 0.247 0.243 rg 0 Tc 1.251 0 Td (-)Tj 0.022 Tc 1.056 0 Td (Clinical )Tj 0.0252 Tc 3.807 0 Td (features )Tj 0.0253 Tc 4.235 0 Td (of )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0232 Tc 8.6 0 0 8.6 170.4114 215.76 Tm (ARDS )Tj EMC ET BT /T1_2 1 Tf 0.0228 Tc 8.6 0 0 8.6 199.0322 215.76 Tm (patients )Tj /T1_0 1 Tf -0.0224 Tc 9.7 0 0 9.7 296.62 739.44 Tm (tion )Tj 0.05 Tc 10.0163 0 0 9.7 316.22 739.44 Tm (of )Tj 0.169 0.169 0.165 rg 0 Tc 9.7 0 0 9.7 329.16 739.44 Tm (6 )Tj ET BT /Suspect <>BDC 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0097 Tc 9.7 0 0 9.7 339.8203 739.44 Tm (mCi\267ml)Tj 0.353 0.353 0.349 rg 0 Tc 3.049 0 Td (\267)Tj 0.247 0.247 0.243 rg 6.2 0 0 6.2 371.79 742.8 Tm (1 )Tj EMC ET BT /T1_0 1 Tf 0.017 Tc 9.7 0 0 9.7 379.67 739.44 Tm (was )Tj 0.169 0.169 0.165 rg 0.0164 Tc 2.121 0 Td (introduced )Tj 0.247 0.247 0.243 rg 0.0152 Tc 4.948 0 Td (into )Tj 0.169 0.169 0.165 rg 0.0097 Tc 2.134 0 Td (the )Tj 0.247 0.247 0.243 rg 0.0051 Tc 1.782 0 Td (nebulizer. )Tj 0.0482 Tc -19.653 -1.137 Td (The )Tj 0.0193 Tc 2.171 0 Td (subject )Tj 0.169 0.169 0.165 rg 0.0137 Tc 3.479 0 Td (breathes )Tj 0.0099 Tc 3.956 0 Td (through )Tj 0.247 0.247 0.243 rg 0 Tc 3.753 0 Td (a )Tj 0.0191 Tc 0.998 0 Td (mouthpiece, )Tj 0.169 0.169 0.165 rg 0.0097 Tc 5.691 0 Td (the )Tj 0.0172 Tc 1.782 0 Td (nose )Tj 0.247 0.247 0.243 rg 0.0165 Tc -21.771 -1.089 Td (being )Tj 0.0181 Tc 2.761 0 Td (closed )Tj 0.169 0.169 0.165 rg 0.0488 Tc 3.128 0 Td (by )Tj 0.247 0.247 0.243 rg 0 Tc 1.523 0 Td (a )Tj 0.169 0.169 0.165 rg 0.0108 Tc 0.999 0 Td (noseclip, )Tj 0.247 0.247 0.243 rg -0.0013 Tc 4.248 0 Td (into )Tj 0.169 0.169 0.165 rg 0.0097 Tc 2.085 0 Td (the )Tj 0.247 0.247 0.243 rg 0.0144 Tc 1.781 0 Td (three-way )Tj 0.0027 Tc 4.652 0 Td (va)Tj 0.071 0.071 0.067 rg 0 Tc 0.983 0 Td (l)Tj 0.247 0.247 0.243 rg 0.0001 Tc 0.254 0 Td (ve. )Tj 0.0049 Tc -22.416 -1.139 Td (Aft)Tj 0.353 0.353 0.349 rg 0 Tc 1.328 0 Td (e)Tj 0.247 0.247 0.243 rg 0.504 0 Td (r )Tj 0.0097 Tc 0.939 0 Td (the )Tj 0.169 0.169 0.165 rg 0.0136 Tc 1.822 0 Td (first )Tj 0.247 0.247 0.243 rg -0.0011 Tc 2.335 0 Td (third )Tj 0.05 Tc 10.5727 0 0 9.7 387.74 706.8 Tm (of )Tj 0 Tc 9.7 0 0 9.7 402.14 706.8 Tm (a )Tj 0.0059 Tc 1.085 0 Td (slow )Tj 0.0032 Tc 2.586 0 Td (vital )Tj 0.0226 Tc 2.418 0 Td (capacity)Tj 0.353 0.353 0.349 rg 0 Tc 3.507 0 Td (, )Tj 0.247 0.247 0.243 rg 0.0193 Tc 0.797 0 Td (every )Tj -21.332 -1.138 Td (subject )Tj 0.012 Tc 3.52 0 Td (inhal)Tj 0.353 0.353 0.349 rg 0.017 Tc 2.027 0 Td (ed )Tj 0.247 0.247 0.243 rg -0.035 Tc 9.0854 0 0 9.7 366.22 695.76 Tm (th)Tj 0.353 0.353 0.349 rg 0 Tc 9.7 0 0 9.7 373.34 695.76 Tm (e )Tj 0.015 Tc 1.089 0 Td (aeroso)Tj 0.247 0.247 0.243 rg 0 Tc 2.724 0 Td [(l )-409(f)]TJ 0.353 0.353 0.349 rg 1.187 0 Td (o)Tj 0.247 0.247 0.243 rg 0.553 0 Td (r )Tj 0.0152 Tc 0.989 0 Td (thr)Tj 0.353 0.353 0.349 rg 0.05 Tc 9.9537 0 0 9.7 447.25 695.76 Tm (ee )Tj 0.247 0.247 0.243 rg /T1_2 1 Tf 8.7717 0 0 8.2 462.68 695.76 Tm (to )Tj /T1_0 1 Tf -0.0013 Tc 9.7 0 0 9.7 476.5 695.76 Tm (six )Tj 0.169 0.169 0.165 rg 0.0059 Tc 1.846 0 Td (breaths, )Tj 0.0005 Tc -20.447 -1.088 Td (dep)Tj 0.353 0.353 0.349 rg 0 Tc 1.434 0 Td (e)Tj 0.169 0.169 0.165 rg 0.013 Tc 0.504 0 Td (nding )Tj 0.247 0.247 0.243 rg 0.0101 Tc 2.812 0 Td (on )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0171 Tc 9.7 0 0 9.7 357.093 685.2064 Tm (th)Tj 0.353 0.353 0.349 rg 0 Tc 0.783 0 Td (e )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 9.7 0 0 9.7 374.3687 685.2064 Tm (v)Tj 0.353 0.353 0.349 rg 0.437 0 Td (e)Tj 0.247 0.247 0.243 rg -0.0137 Tc 0.504 0 Td (ntil)Tj 0.353 0.353 0.349 rg 0 Tc 1.376 0 Td (a)Tj 0.247 0.247 0.243 rg 0.454 0 Td (t)Tj 0.353 0.353 0.349 rg 0.0117 Tc 0.29 0 Td (ory )Tj 0.05 Tc 9.957 0 0 9.7 421.82 685.21 Tm (ca)Tj 0.247 0.247 0.243 rg 0.0062 Tc 9.7 0 0 9.7 431.05 685.21 Tm (pa)Tj 0.353 0.353 0.349 rg -0.035 Tc 9.3843 0 0 9.7 440.55 685.21 Tm (ci)Tj 0.247 0.247 0.243 rg 0 Tc 9.7 0 0 9.7 448.3 685.21 Tm (t)Tj 0.353 0.353 0.349 rg 0.199 0 Td (y )Tj 0.247 0.247 0.243 rg 0.05 Tc 10.5727 0 0 9.7 460.22 685.21 Tm (of )Tj 0.169 0.169 0.165 rg 0.0097 Tc 9.7 0 0 9.7 474.22 685.21 Tm (the )Tj 0.247 0.247 0.243 rg 0.0088 Tc 1.72 0 Td (subjects. )Tj 0.0235 Tc -20.134 -1.138 Td (The )Tj 0.0093 Tc 1.924 0 Td (stability )Tj 0.353 0.353 0.349 rg 0 Tc 3.568 0 Td (o)Tj 0.247 0.247 0.243 rg 0.592 0 Td (f )Tj -0.0324 Tc 0.653 0 Td (th)Tj 0.353 0.353 0.349 rg 0 Tc 0.734 0 Td (e )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 5.4797 0 0 6.4001 375.78 677.53 Tm (99)Tj /T1_0 1 Tf 9.101 0 0 9.7 381.56 674.17 Tm (Dtfc-)Tj 0.247 0.247 0.243 rg 0 Tc 9.7 0 0 9.7 400.28 674.17 Tm (D)Tj 0.353 0.353 0.349 rg 0.0381 Tc 0.689 0 Td (TP)Tj 0.247 0.247 0.243 rg 0 Tc 1.194 0 Td (A )Tj EMC ET BT 0.353 0.353 0.349 rg /T1_0 1 Tf 0.0173 Tc 9.7 0 0 9.7 429.0308 674.17 Tm (co)Tj 0.247 0.247 0.243 rg -0.0078 Tc 0.997 0 Td (mpl)Tj 0.353 0.353 0.349 rg 0 Tc 1.575 0 Td (e)Tj 0.169 0.169 0.165 rg 0.453 0 Td (x )Tj 0.247 0.247 0.243 rg 0.017 Tc 0.843 0 Td (was )Tj 0.0088 Tc 1.922 0 Td (confirmed )Tj 0.0101 Tc -19.546 -1.139 Td (on )Tj 0.0076 Tc 1.484 0 Td (aerosol )Tj 0 Tc 3.41 0 Td (s)Tj 0.353 0.353 0.349 rg 0.4 0 Td (a)Tj 0.247 0.247 0.243 rg 0.503 0 Td (m)Tj 0.353 0.353 0.349 rg 0.795 0 Td (p)Tj 0.247 0.247 0.243 rg 0.535 0 Td (l)Tj 0.353 0.353 0.349 rg 0.029 Tc 0.245 0 Td (es )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0131 Tc 9.7 0 0 9.7 379.5996 663.1217 Tm (obtai)Tj 0.247 0.247 0.243 rg 0 Tc 2.136 0 Td (n)Tj 0.353 0.353 0.349 rg -0.0325 Tc 0.486 0 Td (ed )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf -0.035 Tc 9.5971 0 0 9.7 418.93 663.12 Tm (fr)Tj 0.353 0.353 0.349 rg 0 Tc 9.7 0 0 9.7 425.19 663.12 Tm (o)Tj 0.247 0.247 0.243 rg 0.552 0 Td (m )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.0854 0 0 9.7 443.02 663.12 Tm (th)Tj 0.353 0.353 0.349 rg 0 Tc 9.7 0 0 9.7 450.14 663.12 Tm (e )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0249 Tc 9.7 0 0 9.7 458.7827 663.12 Tm (aeroso)Tj 0.071 0.071 0.067 rg 0 Tc 2.724 0 Td (l )Tj 0.247 0.247 0.243 rg 0.0083 Tc 0.792 0 Td (generat\255)Tj 0.0129 Tc -20.338 -1.089 Td (ing )Tj 0.0155 Tc 1.731 0 Td (circuit )Tj 0.05 Tc 9.7132 0 0 9.7 342.14 652.56 Tm (and )Tj 0.0101 Tc 9.7 0 0 9.7 360.39 652.56 Tm (on )Tj 0.169 0.169 0.165 rg 0.01 Tc 1.495 0 Td (plasma )Tj 0.247 0.247 0.243 rg 0.0122 Tc 3.349 0 Td (samples )Tj 0.0205 Tc 3.717 0 Td (obtained )Tj 0.028 Tc 4.007 0 Td (after )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0094 Tc 9.7 0 0 9.7 504.8618 652.56 Tm (aero\255)Tj EMC ET BT /T1_0 1 Tf 0.0234 Tc 9.7 0 0 9.7 295.5455 641.5311 Tm (sol )Tj 0.0077 Tc 1.936 0 Td (inhalation. )Tj 0.0188 Tc 5.103 0 Td (After )Tj ET BT /Suspect <>BDC 0.169 0.169 0.165 rg /T1_0 1 Tf 0.0097 Tc 9.7 0 0 9.7 392.1478 641.5311 Tm (the )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0175 Tc 9.7 0 0 9.7 410.8785 641.5311 Tm (respiratory )Tj 0.0148 Tc 5.244 0 Td (manoeuvre )Tj 0.169 0.169 0.165 rg 0.0097 Tc 5.295 0 Td (the )Tj 0.247 0.247 0.243 rg 0.0051 Tc -22.425 -1.139 Td (activity )Tj 0.0088 Tc 3.424 0 Td (recovered )Tj -0.0108 Tc 4.394 0 Td (from )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0097 Tc 9.7 0 0 9.7 394.5534 630.4828 Tm (the )Tj EMC ET BT 0.169 0.169 0.165 rg /T1_0 1 Tf 0.0122 Tc 9.7 0 0 9.7 409.9279 630.4828 Tm (nebulizer )Tj 0.247 0.247 0.243 rg 0.017 Tc 4.206 0 Td (was )Tj 0.169 0.169 0.165 rg 0.0052 Tc 1.978 0 Td (measured )Tj 0.247 0.247 0.243 rg 0.0263 Tc 4.247 0 Td (and )Tj 0.0296 Tc -22.21 -1.138 Td (that )Tj 0.0143 Tc 2.03 0 Td (retained )Tj 0.169 0.169 0.165 rg -0.0186 Tc 3.853 0 Td (in )Tj 0.247 0.247 0.243 rg 0.0097 Tc 1.342 0 Td (the )Tj 0.071 0.071 0.067 rg 0 Tc 1.775 0 Td (l)Tj 0.169 0.169 0.165 rg -0.0027 Tc 0.305 0 Td (ungs )Tj 0.247 0.247 0.243 rg 0.017 Tc 2.424 0 Td (was )Tj 0.02 Tc 2.12 0 Td (calculated )Tj -0.0324 Tc 4.758 0 Td (to )Tj 0.0166 Tc 9.6 0 0 9.6 488.65 619.44 Tm (be )Tj 0.0292 Tc 9.7 0 0 9.7 502.94 619.44 Tm (about )Tj 0.0097 Tc 10.5 0 0 10.5 295.62 608.89 Tm (2.5-3 )Tj 0.0046 Tc 9.7 0 0 9.7 321.58 608.89 Tm (mCi. )Tj 0.169 0.169 0.165 rg /T1_2 1 Tf 0 Tc 14.3 0 0 14.3 511.69 506.16 Tm (A )Tj 0.071 0.071 0.067 rg 0.045 -10.003 Td (B )Tj 0.247 0.247 0.243 rg /T1_0 1 Tf -0.0118 Tc 7.8001 0 0 7.8001 295.17 263.28 Tm (Fig)Tj 0.353 0.353 0.349 rg 0 Tc 1.399 0 Td (. )Tj 0.247 0.247 0.243 rg /T1_2 1 Tf -0.035 Tc 7.4329 0 0 8.1 312.72 263.28 Tm (1. )Tj 0.353 0.353 0.349 rg 0 Tc 8.1 0 0 8.1 322.49 263.28 Tm (-)Tj ET BT /Suspect <>BDC 0.247 0.247 0.243 rg /T1_0 1 Tf 0.024 Tc 7.8001 0 0 7.8001 331.11 263.28 Tm (99"'\267DTPA )Tj EMC /Suspect <>BDC 0 Tc 5.223 0 Td (")Tj 0.353 0.353 0.349 rg 0.438 0 Td (-)Tj 0.247 0.247 0.243 rg 0.05 Tc 7.9245 0 0 7.8001 377.71 263.28 Tm (ID )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 6.8183 0 0 7.8001 386.26 263.28 Tm (.. )Tj 0.0208 Tc 7.8001 0 0 7.8001 394.53 263.28 Tm (De)Tj 0.353 0.353 0.349 rg 0.0242 Tc 1.174 0 Td (posit)Tj 0.247 0.247 0.243 rg 0 Tc 2.083 0 Td (i)Tj 0.353 0.353 0.349 rg 0.245 0 Td (o)Tj 0.247 0.247 0.243 rg 0.562 0 Td (n )Tj ET BT /Suspect <>BDC 0.353 0.353 0.349 rg /T1_0 1 Tf 0.05 Tc 7.805 0 0 7.8001 434.41 263.28 Tm (pa)Tj 0.247 0.247 0.243 rg 0 Tc 7.8001 0 0 7.8001 442.08 263.28 Tm (u)Tj 0.353 0.353 0.349 rg 0.606 0 Td (c)Tj 0.247 0.247 0.243 rg 0.5 0 Td (m )Tj EMC ET BT 0.353 0.353 0.349 rg /T1_2 1 Tf -0.035 Tc 7.5134 0 0 7.8001 462.1 263.28 Tm (in )Tj /T1_0 1 Tf 0.0277 Tc 7.8001 0 0 7.8001 472.72 263.28 Tm (CIPO )Tj 0 Tc 2.953 0 Td (\()Tj 0.169 0.169 0.165 rg 0.05 Tc 7.8604 0 0 7.8001 498.23 263.28 Tm (A\) )Tj 0.247 0.247 0.243 rg -0.0083 Tc 7.8001 0 0 7.8001 511.12 263.28 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0047 Tc 7.8001 0 0 7.8001 295.1898 255.6125 Tm (ARDS )Tj EMC ET BT /T1_0 1 Tf -0.0104 Tc 7.8001 0 0 7.8001 319.1127 255.6125 Tm (\(B\) )Tj -0.003 Tc 1.736 0 Td (patients. )Tj 0.0184 Tc 3.751 0 Td (Anterior )Tj 0.0109 Tc 3.815 0 Td (view )Tj ET BT /Suspect <>BDC 0.353 0.353 0.349 rg /T1_0 1 Tf 0.0146 Tc 7.8001 0 0 7.8001 410.2881 255.6125 Tm (soon )Tj EMC /Suspect <>BDC 0.0178 Tc 2.281 0 Td (afte)Tj 0.247 0.247 0.243 rg 0 Tc 1.609 0 Td (r )Tj EMC /Suspect <>BDC 0.677 0 Td (n)Tj 0.353 0.353 0.349 rg 0.0014 Tc 0.545 0 Td (ebulization)Tj 0.506 0.506 0.498 rg 0 Tc 4.482 0 Td (. )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 0.05 Tc 7.9192 0 0 7.8001 489.53 255.61 Tm (The )Tj 0.0117 Tc 7.8001 0 0 7.8001 504.89 255.61 Tm (depo)Tj 0.353 0.353 0.349 rg 0 Tc 2.028 0 Td (\255)Tj 0.247 0.247 0.243 rg 0.0041 Tc -28.925 -1.047 Td (sition )Tj 0.0036 Tc 2.714 0 Td (images )Tj 0.0422 Tc 3.259 0 Td (are )Tj 0.0252 Tc 1.671 0 Td (very )Tj 0.0241 Tc 2.264 0 Td (similar )Tj /T1_2 1 Tf -0.0086 Tc 7.9001 0 0 7.9001 398.25 247.44 Tm (in )Tj ET BT /Suspect <>BDC 0.353 0.353 0.349 rg /T1_0 1 Tf -0.0304 Tc 8.5 0 0 8.5 407.53 247.44 Tm (bo)Tj 0.247 0.247 0.243 rg -0.035 Tc 7.7875 0 0 8.5 416.14 247.44 Tm (th )Tj EMC ET BT 0.353 0.353 0.349 rg /T1_0 1 Tf 0.05 Tc 7.8387 0 0 7.8001 424.81 247.44 Tm (pu)Tj 0.247 0.247 0.243 rg 0 Tc 7.8001 0 0 7.8001 433.86 247.44 Tm (l)Tj 0.353 0.353 0.349 rg 0.0198 Tc 0.253 0 Td (mo)Tj 0.247 0.247 0.243 rg 0 Tc 1.354 0 Td (n)Tj 0.353 0.353 0.349 rg 0.0137 Tc 0.483 0 Td (ary )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0099 Tc 7.8001 0 0 7.8001 463.6096 247.44 Tm (conditions. )Tj EMC ET BT 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0057 Tc 8.8 0 0 8.8 43.16 196.57 Tm (Patien)Tj 0.353 0.353 0.349 rg 0 Tc 2.62 0 Td (t )Tj 0.247 0.247 0.243 rg 0.0159 Tc 5.236 0 Td (Age )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0041 Tc 8.8 0 0 8.8 185.1128 196.57 Tm (Sex )Tj EMC /Suspect <>BDC 0.0223 Tc 6.491 0 Td (Smoking )Tj EMC ET BT /T1_0 1 Tf -0.0084 Tc 8.8 0 0 8.8 278.8592 196.57 Tm (habi)Tj 0.353 0.353 0.349 rg 0 Tc 1.744 0 Td (t )Tj 0.247 0.247 0.243 rg 0.003 Tc 5.07 0.055 Td (Predisposing )Tj 0.0091 Tc 5.612 0 Td (condi)Tj 0.353 0.353 0.349 rg 0 Tc 2.299 0 Td (t)Tj 0.247 0.247 0.243 rg -0.0032 Tc 0.322 0 Td (ion )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0008 Tc 8.8 0 0 8.8 482.7728 197.5204 Tm (Outcome* )Tj EMC ET BT /T1_0 1 Tf 0.0397 Tc 8.8 0 0 8.8 42.6936 186.9692 Tm (no)Tj 0.353 0.353 0.349 rg 0 Tc 1.072 0 Td (. )Tj 0.247 0.247 0.243 rg 0.05 Tc 8.7304 0 0 8.6 115.19 186.97 Tm (yr )Tj 0 Tc 9.3 0 0 9.3 43.36 167.76 Tm (1 )Tj 0.05 Tc 8.9782 0 0 8.6 115.08 168.25 Tm (54 )Tj 0 Tc 8.8 0 0 8.8 188.12 168.25 Tm (M )Tj -0.0094 Tc 8.184 0 Td (Yes** )Tj 0.0166 Tc 8.18 0.055 Td (Multiple )Tj 0.0131 Tc 3.93 0 Td (trauma )Tj 0.0127 Tc 13.798 0.055 Td (Died )Tj 0 Tc 8.6 0 0 8.6 42.67 158.65 Tm (2 )Tj 0.0268 Tc 9.1 0 0 9.1 115.1 158.65 Tm (72 )Tj 0.169 0.169 0.165 rg /T1_2 1 Tf 0 Tc 8.8 0 0 8.8 187.49 158.65 Tm (M )Tj 0.247 0.247 0.243 rg /T1_0 1 Tf 8.208 0.055 Td (N)Tj 0.353 0.353 0.349 rg 0.75 0 Td (o )Tj ET BT /Suspect <>BDC 0.247 0.247 0.243 rg /T1_0 1 Tf -0.0001 Tc 8.8 0 0 8.8 332.0036 159.618 Tm (Septi)Tj 0.353 0.353 0.349 rg 0 Tc 2.081 0 Td (c)Tj 0.247 0.247 0.243 rg 0.0207 Tc 0.491 0 Td (aemia )Tj EMC ET BT /T1_0 1 Tf 0.0028 Tc 8.8 0 0 8.8 379.6204 159.618 Tm (in )Tj 0.0285 Tc 1.143 0 Td (cancer )Tj 0.0123 Tc 3.12 0 Td (patient )Tj 0.0127 Tc 8.067 0 Td (Died )Tj 0.353 0.353 0.349 rg 0 Tc 9.5 0 0 9.5 42.61 149.05 Tm (3 )Tj 0.247 0.247 0.243 rg 0.05 Tc 8.9782 0 0 8.6 115.08 149.05 Tm (52 )Tj /T1_2 1 Tf 0 Tc 8.6 0 0 8.6 187.47 149.05 Tm (F )Tj /T1_0 1 Tf 0.0325 Tc 8.8 0 0 8.8 259.72 149.05 Tm (No )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0174 Tc 8.8 0 0 8.8 332.0032 150.0092 Tm (Septicaemia )Tj EMC ET BT /T1_2 1 Tf 0.0259 Tc 8.8 0 0 8.8 379.5144 150.0092 Tm (in )Tj /T1_0 1 Tf 0.0176 Tc 1.209 0 Td (cancer )Tj 0.0123 Tc 3.066 0 Td (patient )Tj -0.0006 Tc 8.067 0 Td (Di)Tj 0.353 0.353 0.349 rg 0 Tc 0.976 0 Td (e)Tj 0.247 0.247 0.243 rg 0.492 0 Td (d )Tj 8.6 0 0 8.6 42.68 139.93 Tm (4 )Tj 0.05 Tc 8.8941 0 0 8.6 115.09 139.93 Tm (62 )Tj /T1_2 1 Tf 0 Tc 9.1 0 0 9.1 187 139.93 Tm (M )Tj /T1_0 1 Tf 8.8 0 0 8.8 259.72 139.93 Tm (N)Tj 0.353 0.353 0.349 rg 0.75 0 Td (o )Tj 0.247 0.247 0.243 rg 7.477 0.055 Td (M)Tj 0.353 0.353 0.349 rg 0.932 0 Td (u)Tj 0.247 0.247 0.243 rg 0.0067 Tc 0.483 0 Td (lt)Tj 0.353 0.353 0.349 rg 0.0155 Tc 0.6 0 Td (iple )Tj 0.247 0.247 0.243 rg -0.0077 Tc 1.915 0 Td (tr)Tj 0.353 0.353 0.349 rg -0.0047 Tc 0.592 0 Td (au)Tj 0.247 0.247 0.243 rg 0 Tc 0.99 0 Td (m)Tj 0.353 0.353 0.349 rg 0.81 0 Td (a )Tj 0.247 0.247 0.243 rg 11.406 0.055 Td (D)Tj 0.353 0.353 0.349 rg 0.76 0 Td (i)Tj 0.247 0.247 0.243 rg 0.004 Tc 0.27 0 Td (ed )Tj /T1_1 1 Tf 0 Tc 10 0 0 10 42.62 129.85 Tm (5 )Tj /T1_2 1 Tf -0.035 Tc 7.7785 0 0 8.6 115.09 130.33 Tm (71 )Tj 0 Tc 8.6 0 0 8.6 187.95 130.33 Tm (F )Tj /T1_0 1 Tf -0.0221 Tc 8.8 0 0 8.8 259.72 130.33 Tm (No )Tj ET BT /Suspect <>BDC 0.353 0.353 0.349 rg /T1_0 1 Tf 0.0119 Tc 8.8 0 0 8.8 332.0032 131.2892 Tm (Septicaemia )Tj EMC ET BT /T1_0 1 Tf 0.0028 Tc 8.8 0 0 8.8 379.6112 131.2892 Tm (in )Tj 0.506 0.506 0.498 rg 0 Tc 1.143 0 Td (c)Tj 0.353 0.353 0.349 rg 0.0214 Tc 0.491 0 Td (ancer )Tj 0.0047 Tc 2.63 0 Td (patien)Tj 0.247 0.247 0.243 rg 0 Tc 2.56 0 Td (t )Tj -0.0006 Tc 5.507 0 Td (Di)Tj 0.353 0.353 0.349 rg 0 Tc 1.031 0 Td (e)Tj 0.247 0.247 0.243 rg 0.383 0 Td (d )Tj /T1_2 1 Tf 8.3 0 0 8.3 42.63 120.72 Tm (6 )Tj /T1_0 1 Tf -0.0266 Tc 8.6 0 0 8.6 115.09 120.72 Tm (65 )Tj /T1_2 1 Tf 0 Tc 9.1 0 0 9.1 187 120.72 Tm (M )Tj /T1_0 1 Tf 8.8 0 0 8.8 259.66 121.2 Tm (Y)Tj 0.353 0.353 0.349 rg 0.756 0 Td (e)Tj 0.247 0.247 0.243 rg -0.0001 Tc 0.433 0 Td (s** )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 332.6032 121.684 Tm (P)Tj 0.353 0.353 0.349 rg 0.0089 Tc 0.494 0 Td (rolo)Tj 0.247 0.247 0.243 rg 0 Tc 1.636 0 Td (n)Tj 0.353 0.353 0.349 rg -0.0051 Tc 0.539 0 Td (ged )Tj EMC /Suspect <>BDC 0.0149 Tc 1.861 0 Td (hypotens)Tj 0.247 0.247 0.243 rg 0 Tc 3.757 0 Td (i)Tj 0.353 0.353 0.349 rg 0.0022 Tc 0.272 0 Td (on )Tj EMC ET BT /T1_0 1 Tf 0.0466 Tc 8.8 0 0 8.8 420.4008 121.684 Tm (due )Tj /T1_2 1 Tf 0.05 Tc 7.127 0 0 6.9001 437.25 121.68 Tm (to )Tj 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0194 Tc 8.8 0 0 8.8 488.14 122.16 Tm (Alive )Tj 0 Tc 9.6 0 0 9.6 42.62 102 Tm (7 )Tj /T1_1 1 Tf -0.035 Tc 9.115 0 0 10 115.11 102 Tm (55 )Tj /T1_2 1 Tf 0 Tc 8.6 0 0 8.6 187.47 102 Tm (F )Tj /T1_0 1 Tf -0.0221 Tc 8.8 0 0 8.8 259.72 102 Tm (No )Tj 0.353 0.353 0.349 rg 0.0099 Tc 8.23 1.145 Td (massive )Tj 0.019 Tc 3.658 0 Td (pulmonary )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0172 Tc 8.8 0 0 8.8 407.0232 112.076 Tm (thomoocmb)Tj 0.247 0.247 0.243 rg 0.0014 Tc 4.957 0 Td (oli)Tj 0.353 0.353 0.349 rg 0 Tc 1.086 0 Td (s)Tj 0.247 0.247 0.243 rg 0.393 0 Td (m )Tj EMC ET BT /T1_0 1 Tf 0.0166 Tc 8.8 0 0 8.8 331.6424 102.4752 Tm (Multiple )Tj 0.0241 Tc 3.93 0 Td (trauma )Tj 0.169 0.169 0.165 rg -0.0006 Tc 13.852 0.055 Td (Di)Tj 0.353 0.353 0.349 rg 0 Tc 0.976 0 Td (e)Tj 0.247 0.247 0.243 rg 0.492 0 Td (d )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0253 Tc 8.8 0 0 8.8 42.5448 83.2824 Tm (*: )Tj EMC ET BT 0.169 0.169 0.165 rg /T1_0 1 Tf 0.0194 Tc 8.8 0 0 8.8 52.788 83.2824 Tm (All )Tj 0.247 0.247 0.243 rg 0.0041 Tc 1.684 0 Td (deaths )Tj 0.169 0.169 0.165 rg 0 Tc 3.063 0 Td (w)Tj 0.353 0.353 0.349 rg 0.7 0 Td (e)Tj 0.169 0.169 0.165 rg 0.0425 Tc 0.445 0 Td (re )Tj 0.247 0.247 0.243 rg 0 Tc 1.191 0 Td (a )Tj 0.0163 Tc 0.874 0 Td (direct )Tj 0.353 0.353 0.349 rg 0 Tc 2.672 0 Td (c)Tj 0.247 0.247 0.243 rg 0.0159 Tc 0.492 0 Td (onsequ)Tj 0.353 0.353 0.349 rg 0 Tc 2.89 0 Td (e)Tj 0.247 0.247 0.243 rg 0.0177 Tc 0.5 0 Td (nce )Tj 0 Tc 1.792 0 Td (o)Tj 0.353 0.353 0.349 rg 0.543 0 Td (f )Tj ET BT /Suspect <>BDC 0.247 0.247 0.243 rg /T1_0 1 Tf 0.0021 Tc 8.8 0 0 8.8 207.3512 83.2824 Tm (ARDS; )Tj EMC ET BT /T1_0 1 Tf -0.0172 Tc 8.8 0 0 8.8 237.4296 83.2824 Tm (**: )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0054 Tc 8.8 0 0 8.8 252.328 83.2824 Tm (See )Tj EMC ET BT /T1_0 1 Tf 0.0033 Tc 8.8 0 0 8.8 268.784 83.2824 Tm (methods. )Tj ET endstream 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570.7200012 812.6399994 cm /Im3 Do Q q 18.2400055 0 0 12.4799957 278.8800049 807.8399963 cm /Im4 Do Q q 16.3200073 0 0 179.5200043 0.4799957 620.6399994 cm /Im5 Do Q q 12.9600067 0 0 30.7200012 0 540.9600067 cm /Im6 Do Q q 12.9600067 0 0 15.3600006 0 517.9199982 cm /Im7 Do Q q 9.1199951 0 0 12 0 312 cm /Im8 Do Q q 12.9600067 0 0 16.3200073 0 63.8399963 cm /Im9 Do Q q 12.9600067 0 0 14.3999939 0 48.4799957 cm /Im10 Do Q q 28.3200073 0 0 14.3999939 0 21.6000061 cm /Im11 Do Q BT /Suspect <>BDC 0.188 0.188 0.184 rg /T1_0 1 Tf 0.0091 Tc 3 Tr 9 0 0 9 60.38 768.73 Tm (920 )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.0578 0 0 8 261.05 768.24 Tm (T. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0109 Tc 8 0 0 8 273.05 768.24 Tm (TODISCO )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.4 0 0 8 311.95 768.24 Tm (ET )Tj 8.0222 0 0 8 326.39 768.24 Tm (AL )Tj 0.0492 Tc 9 0 0 9 59.44 742.33 Tm (Table )Tj /T1_1 1 Tf 0.05 Tc 12.3734 0 0 9 84.38 742.33 Tm (2.-)Tj -0.0049 Tc 9 0 0 9 102.52 742.33 Tm (PAEP )Tj /T1_0 1 Tf 0.0379 Tc 3.001 0 Td (indices )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0132 Tc 7.9001 0 0 7.9001 160.26 742.33 Tm ({t)Tj /T1_0 1 Tf 0 Tc 5.7 0 0 5.7 165.06 739.44 Tm (0)Tj 0.6 0.604 0.6 rg 0.579 0.507 Td (.)Tj 0.188 0.188 0.184 rg 0.344 -0.507 Td (5 )Tj EMC ET BT /T1_0 1 Tf -0.0132 Tc 9 0 0 9 176.62 742.33 Tm (min, )Tj 0.05 Tc 9.0872 0 0 9 196.3 742.33 Tm (mean\261so\) )Tj -0.035 Tc 8.5969 0 0 9 238.97 742.33 Tm (in )Tj 0.05 Tc 9.3105 0 0 9 248.1 742.33 Tm (22 )Tj 0.032 Tc 9 0 0 9 261.11 742.33 Tm (normal )Tj 0.0378 Tc 3.36 0 Td (nonsmoking )Tj 0.05 Tc 9.2132 0 0 9 341.63 742.33 Tm (subjects )Tj 9.3999 0 0 9 377.66 742.33 Tm (and )Tj 9.81 0 0 9 395.18 742.33 Tm (13 )Tj 0.0427 Tc 9 0 0 9 407.99 742.33 Tm (normal )Tj 0.0437 Tc 3.347 0 Td (smoking )Tj 0.05 Tc 9.3487 0 0 9 474.59 742.33 Tm (subjects )Tj 0.0252 Tc 9 0 0 9 513.49 741.85 Tm (\(group )Tj /T1_1 1 Tf 0.0407 Tc 8.5 0 0 8.5 58.94 731.76 Tm (3\) )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0193 Tc 9 0 0 9 203.96 708.24 Tm (Ri)Tj 0.31 g 0 Tc 0.956 0 Td (g)Tj 0.188 0.188 0.184 rg 0.0269 Tc 0.488 0 Td (ht )Tj EMC /Suspect <>BDC -0.0006 Tc 1.006 0 Td (lung )Tj EMC ET BT /T1_0 1 Tf -0.0274 Tc 9 0 0 9 421.877 708.726 Tm (Le)Tj 0.376 g 0 Tc 1.061 0 Td (f)Tj 0.188 0.188 0.184 rg 0.329 0 Td (t )Tj -0.0006 Tc 0.527 0 Td (lung )Tj 0.0159 Tc -34.554 -1.28 Td (Whole )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0035 Tc 9 0 0 9 185.285 696.729 Tm (Upper )Tj EMC ET BT /T1_0 1 Tf 0.0116 Tc 9 0 0 9 238.538 696.729 Tm (Middle )Tj 0.0044 Tc 6.026 0 Td (Lower )Tj 0.0159 Tc 5.922 0 Td (Whole )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0035 Tc 9 0 0 9 400.331 696.729 Tm (Upper )Tj EMC ET BT /T1_0 1 Tf 0.0116 Tc 9 0 0 9 456.941 696.729 Tm (Middle )Tj 0.0044 Tc 5.759 -0.054 Td (Lower )Tj -0.0044 Tc -49.963 -2.399 Td (Nonsmokers )Tj 0.0118 Tc 7.711 -0.053 Td (85\26134 )Tj 0.0115 Tc 6.244 0 Td (52\26119 )Tj -0.0149 Tc 6.022 0 Td (89\26137 )Tj -0.0016 Tc 5.973 0 Td [(85\26134 )-3169(83\26126 )]TJ -0.0018 Tc 11.951 0 Td (57\26129 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0226 Tc 9 0 0 9 456.392 674.175 Tm (90\26134 )Tj EMC /Suspect <>BDC 0.0092 Tc 5.813 -0.054 Td (94\26150 )Tj EMC /Suspect <>BDC 0.0005 Tc -49.98 -2.133 Td (Smokers )Tj EMC ET BT /T1_0 1 Tf 0.0068 Tc 9 0 0 9 128.126 654.492 Tm (43\26114 )Tj 6.24 -0.053 Td (43\26115 )Tj -0.0065 Tc 6.027 0.053 Td (41\26119 )Tj -0.0011 Tc 5.967 -0.053 Td (37\26111 )Tj 0.0068 Tc 5.98 0.053 Td (49\26117 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0202 Tc 9 0 0 9 399.809 654.015 Tm (44\26120 )Tj EMC ET BT /T1_0 1 Tf 9 0 0 9 455.969 654.015 Tm (43\26119 )Tj -0.0011 Tc 5.86 0 Td (34\26115 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0231 Tc 9 0 0 9 59.006 634.818 Tm (PAEP: )Tj EMC ET BT /T1_0 1 Tf -0.0001 Tc 9 0 0 9 86.42 634.818 Tm (pulmonary )Tj -0.0007 Tc 4.736 0 Td (alveolar )Tj 0.0043 Tc 3.572 0 Td (epithelial )Tj -0.0007 Tc 4.066 0 Td (permeability. )Tj 0.0048 Tc 5.642 0 Td (Comparison )Tj 0.0023 Tc 5.289 0 Td (within )Tj 0.0004 Tc 2.872 0 Td (groups: )Tj 0.0083 Tc 3.368 0 Td (right )Tj 0.0172 Tc 2.232 0 Td (lung )Tj /T1_2 1 Tf 0.0164 Tc 7.6 0 0 7.6 391.98 634.8 Tm (vs )Tj /T1_0 1 Tf 0.024 Tc 9 0 0 9 402.64 634.8 Tm (left )Tj -0.0096 Tc 1.707 0 Td (lung, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0042 Tc 9 0 0 9 439.72 634.8 Tm (NS; )Tj EMC ET BT /T1_0 1 Tf 0.0217 Tc 9 0 0 9 456.946 634.8 Tm (right )Tj -0.0006 Tc 2.286 0 Td (lung )Tj -0.006 Tc 2.191 0 Td (ROI )Tj /T1_2 1 Tf 0.0164 Tc 7.6 0 0 7.6 515.82 634.8 Tm (vs )Tj /T1_0 1 Tf 0.0062 Tc 9 0 0 9 526.48 634.8 Tm (left )Tj -0.0006 Tc -52 -1.227 Td (lung )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0162 Tc 9 0 0 9 77.236 623.757 Tm (ROI, )Tj EMC /Suspect <>BDC -0.0042 Tc 2.249 0 Td (NS; )Tj EMC /Suspect <>BDC 0.0028 Tc 1.861 0 Td (nonsmokers )Tj EMC ET BT /T1_0 1 Tf 0.0217 Tc 9 0 0 9 160.306 623.757 Tm (right )Tj 0.004 Tc 2.231 0 Td (and )Tj 0.0062 Tc 1.761 0 Td (left )Tj 0.0178 Tc 1.609 0 Td (upper )Tj -0.0327 Tc 2.609 0 Td (ROI )Tj /T1_2 1 Tf 0.0164 Tc 7.6 0 0 7.6 251.82 623.76 Tm (vs )Tj /T1_0 1 Tf 0.0083 Tc 9 0 0 9 264.47 623.76 Tm (right )Tj 0.004 Tc 2.231 0 Td (and )Tj 0.0062 Tc 1.708 0 Td (left )Tj 0.0057 Tc 1.607 0 Td (middle-lower )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0015 Tc 9 0 0 9 365.72 623.76 Tm (ROI, )Tj EMC /Suspect <>BDC -0.0068 Tc 2.299 0 Td (p<0.01; )Tj EMC /Suspect <>BDC 0.009 Tc 3.344 0 Td (smokers )Tj EMC ET BT /T1_0 1 Tf 0.0083 Tc 9 0 0 9 449.267 623.76 Tm (right )Tj 0.004 Tc 2.231 0 Td (and )Tj 0.0062 Tc 1.761 0 Td (left )Tj 0.0045 Tc 1.609 0 Td (upper )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.006 Tc 9 0 0 9 523.157 623.76 Tm (ROI )Tj EMC ET BT /T1_2 1 Tf -0.035 Tc 7.5073 0 0 7.6 58.87 611.76 Tm (vs )Tj /T1_0 1 Tf 0.0083 Tc 9 0 0 9 69.11 611.76 Tm (right )Tj 0.004 Tc 2.284 0 Td (and )Tj 0.0062 Tc 1.814 0 Td (left )Tj 0.0057 Tc 1.713 0 Td (middle-lower )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0015 Tc 9 0 0 9 173.231 611.76 Tm (ROI, )Tj EMC /Suspect <>BDC -0.035 Tc 8.8814 0 0 9 194.44 611.76 Tm (NS)Tj 0.31 g 0 Tc 9 0 0 9 206.21 611.76 Tm (. )Tj EMC /Suspect <>BDC 0.188 0.188 0.184 rg 0.0342 Tc 6.8001 0 0 6.8001 211.71 611.76 Tm (NS: )Tj EMC ET BT /T1_0 1 Tf 0.0298 Tc 9 0 0 9 226.07 611.76 Tm (not )Tj -0.0013 Tc 1.693 0 Td (significant. )Tj 0.05 Tc 9.1837 0 0 9 58 573.85 Tm (Table )Tj 0.0336 Tc 9 0 0 9 84.38 573.85 Tm (3. )Tj 0 Tc 1.227 0 Td (-)Tj /T1_1 1 Tf -0.0049 Tc 1.056 0 Td (PAEP )Tj 0.0403 Tc 8.5 0 0 8.5 132.33 573.85 Tm (\(t)Tj /T1_0 1 Tf 0 Tc 5.7 0 0 5.7 137.7 570.48 Tm (0)Tj 0.6 0.604 0.6 rg 0.579 0.591 Td (.)Tj 0.188 0.188 0.184 rg 0.344 -0.591 Td (5)Tj 0.588 0.591 Td (, )Tj -0.0044 Tc 9 0 0 9 152.62 573.85 Tm (min; )Tj 0.05 Tc 9.3116 0 0 9 173.26 573.85 Tm (mean\261so\) )Tj -0.035 Tc 7.9356 0 0 9 217.38 573.85 Tm (in )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.005 Tc 9 0 0 9 227.87 573.85 Tm (CIPO )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.3999 0 0 9 253.34 573.85 Tm (and )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.019 Tc 9 0 0 9 272.17 573.85 Tm (ARDS )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.0514 0 0 9 300.97 573.85 Tm (patients )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0126 Tc 9 0 0 9 199.59 553.21 Tm (CIPO )Tj EMC /Suspect <>BDC -0.0156 Tc 24.061 0.052 Td (ARDS )Tj EMC ET BT /T1_0 1 Tf -0.0078 Tc 9 0 0 9 191.958 533.527 Tm (Right )Tj -0.0006 Tc 2.449 0 Td (lung )Tj 0.0056 Tc 21.764 0.052 Td (Right )Tj -0.0006 Tc 2.502 0 Td (lung )Tj 0.0115 Tc -41.649 -2.186 Td (Patient )Tj 0.0026 Tc 5.014 0 Td (Whole )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 9 0 0 9 157.416 513.844 Tm (U)Tj 0.31 g 0.737 0 Td (-)Tj 0.188 0.188 0.184 rg -0.006 Tc 0.327 0 Td (ROI )Tj EMC ET BT /T1_0 1 Tf 0.0002 Tc 9 0 0 9 212.109 513.844 Tm (M-ROI )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0037 Tc 9 0 0 9 265.38 513.844 Tm (L-ROI )Tj EMC ET BT /T1_0 1 Tf 0.0026 Tc 9 0 0 9 315.789 513.844 Tm (Patient )Tj 5.761 0.053 Td (Whole )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0127 Tc 9 0 0 9 422.376 513.844 Tm (U-ROI )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9 0 0 9 463.146 513.844 Tm (M)Tj 0.31 g 0.953 0 Td (-)Tj 0.188 0.188 0.184 rg -0.006 Tc 0.38 0 Td (ROI )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0037 Tc 9 0 0 9 513.537 513.844 Tm (L-ROI )Tj EMC ET BT /T1_0 1 Tf 0.0166 Tc 9 0 0 9 57.579 504.241 Tm (no)Tj 0.31 g 0 Tc 1.047 0 Td (. )Tj 0.188 0.188 0.184 rg -0.01 Tc 28.447 -0.054 Td (no. )Tj 0 Tc -29.473 -2.133 Td (1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0379 Tc 9 0 0 9 111.732 484.09 Tm (60 )Tj EMC /Suspect <>BDC 0.0484 Tc 6.021 0 Td (80 )Tj EMC ET BT /T1_0 1 Tf 0.0475 Tc 9 0 0 9 219.723 484.09 Tm (58 )Tj 0.0379 Tc 5.708 0 Td (68 )Tj -0.0219 Tc 5.844 0 Td [(14 )-4576(17 )]TJ ET BT /Suspect <>BDC /T1_0 1 Tf 0.0322 Tc 9 0 0 9 429.072 484.09 Tm (20 )Tj EMC ET BT /T1_0 1 Tf -0.0211 Tc 9 0 0 9 474.189 484.09 Tm (23 )Tj 0.0322 Tc 5.227 0 Td (22 )Tj 0 Tc -51.52 -1.067 Td (2 )Tj 0.0052 Tc 9.3 0 0 9.3 111.73 474 Tm (64 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.3623 0 0 9 165.5 474.49 Tm (70 )Tj EMC ET BT /T1_0 1 Tf 0.0379 Tc 9 0 0 9 219.73 474 Tm (66 )Tj -0.0154 Tc 5.707 0 Td (65 )Tj -0.0219 Tc 5.791 0 Td (15 )Tj 5.813 0.054 Td [(14 )-4789(18 )]TJ 0.0314 Tc 10.987 -0.054 Td (16 )Tj -0.035 Tc 8.5945 0 0 9 521.94 474 Tm (16 )Tj 0 Tc 9 0 0 9 57.5 464.41 Tm (3 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.4507 0 0 9 111.23 463.93 Tm (50 )Tj EMC ET BT /T1_0 1 Tf -0.0058 Tc 9 0 0 9 165.48 463.93 Tm [(51 )-4794(53 )]TJ 0.05 Tc 9.2781 0 0 9 270.68 464.41 Tm (46 )Tj -0.0219 Tc 9 0 0 9 323.21 463.93 Tm (16 )Tj 5.813 0.053 Td (18 )Tj -0.035 Tc 8.6249 0 0 9 429.07 464.41 Tm (21 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0322 Tc 9 0 0 9 474.19 463.93 Tm (20 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.5945 0 0 9 521.94 463.93 Tm (18 )Tj 0 Tc 9 0 0 9 57.08 454.81 Tm (4 )Tj 0.0475 Tc 6.018 0 Td (54 )Tj -0.0058 Tc 6.027 -0.053 Td (57 )Tj 0.0475 Tc 6.027 0 Td (52 )Tj -0.035 Tc 8.7667 0 0 9 271.08 454.33 Tm (51 )Tj -0.0219 Tc 9 0 0 9 323.21 454.33 Tm [(17 )-4576(15 )]TJ 0.0314 Tc 11.787 0 Td (16 )Tj -0.0219 Tc 5.013 0 Td (17 )Tj 5.227 -0.054 Td (18 )Tj /T1_3 1 Tf 0 Tc 10 0 0 10 57.5 444.25 Tm (5 )Tj /T1_0 1 Tf -0.035 Tc 8.7667 0 0 9 111.24 444.25 Tm (51 )Tj -0.0058 Tc 9 0 0 9 165.48 444.25 Tm [(53 )-4794(58 )-4474(56 )]TJ -0.0219 Tc 17.526 0 Td (18 )Tj -0.035 Tc 8.5945 0 0 9.1 375.06 444.25 Tm (11 )Tj -0.0219 Tc 9 0 0 9 429.29 444.25 Tm (13 )Tj -0.035 Tc 8.5945 0 0 9 474.42 444.25 Tm (11 )Tj -0.0219 Tc 9 0 0 9 521.93 443.76 Tm (12 )Tj 0 Tc -51.658 -1.067 Td (6 )Tj -0.0247 Tc 6.034 0.054 Td (48 )Tj 0.0286 Tc 5.973 0 Td (48 )Tj 0.0475 Tc 6.018 -0.054 Td (57 )Tj -0.0154 Tc 5.761 0 Td (63 )Tj -0.0219 Tc 5.791 0 Td [(19 )-4576(18 )-4842(18 )]TJ -0.0211 Tc 16.722 0 Td [(21 )-4093(23 )]TJ 0 Tc -46.299 -1.067 Td (7 )Tj 0.0379 Tc 6.027 0 Td (74 )Tj -0.0154 Tc 6.026 0 Td [(63 )-4823(67 )]TJ ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.3623 0 0 9 270.62 424.56 Tm (70 )Tj EMC /Suspect <>BDC 0.0322 Tc 9 0 0 9 322.51 424.56 Tm (20 )Tj EMC ET BT /T1_0 1 Tf -0.0219 Tc 9 0 0 9 375.052 424.56 Tm [(15 )-4842(18 )]TJ 9 0 0 9 322.51 424.56 Tm 16.877 0 Td (19 )Tj -0.035 Tc 8.5945 0 0 9 521.94 424.09 Tm (17 )Tj 0 Tc 9 0 0 9 56.96 414.49 Tm (8 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.3623 0 0 9 110.78 414.49 Tm (70 )Tj EMC ET BT /T1_0 1 Tf 0.0052 Tc 9.3 0 0 9.3 165.49 414.49 Tm (64 )Tj -0.0154 Tc 9 0 0 9 219.25 414 Tm (65 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.3623 0 0 9 270.62 414.49 Tm (70 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.8 0 0 9.8 56.53 403.93 Tm (9 )Tj -0.0154 Tc 9 0 0 9 111.25 403.93 Tm [(66 )-4823(62 )]TJ -0.035 Tc 8.6773 0 0 9 219.27 403.93 Tm (71 )Tj -0.0154 Tc 9 0 0 9 271.09 403.93 Tm (68 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0219 Tc 9 0 0 9 57.286 394.327 Tm (10 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.6772 0 0 9 111.25 394.33 Tm (61 )Tj 0.0286 Tc 9 0 0 9 165.08 394.33 Tm (44 )Tj -0.0058 Tc 6.018 -0.054 Td (53 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0379 Tc 9 0 0 9 270.614 394.33 Tm (60 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.0574 0 0 9 57.32 384.25 Tm (11 )Tj 0.0268 Tc 9.1 0 0 9.1 110.78 384.25 Tm (72 )Tj 0.0379 Tc 9 0 0 9 165.01 384.25 Tm (66 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9 0 0 9 219.262 384.25 Tm (70 )Tj EMC ET BT /T1_0 1 Tf -0.0154 Tc 9 0 0 9 270.616 384.25 Tm (68 )Tj -0.0219 Tc -23.702 -1.067 Td (12 )Tj -0.0154 Tc 5.942 -0.054 Td (68 )Tj 0.0286 Tc 6.034 0 Td (42 )Tj -0.0154 Tc 6.019 0 Td (67 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0379 Tc 9 0 0 9 270.625 374.161 Tm (70 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.5945 0 0 9 57.3 364.56 Tm (13 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0379 Tc 9 0 0 9 110.78 364.56 Tm (70 )Tj EMC ET BT /T1_0 1 Tf -0.0058 Tc 9 0 0 9 164.996 364.56 Tm (57 )Tj -0.0154 Tc 6.028 0 Td (67 )Tj /T1_1 1 Tf -0.035 Tc 8.6936 0 0 9.1 270.6 364.56 Tm (72 )Tj /T1_0 1 Tf 0.0034 Tc 9 0 0 9 56.14 354.97 Tm (mean\261 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.9809 0 0 9 80.98 354.97 Tm (so )Tj EMC ET BT /T1_0 1 Tf 0.0011 Tc 9 0 0 9 103.57 354.49 Tm (62\2619 )Tj -0.0018 Tc 6.186 0 Td (58\26111 )Tj -0.0167 Tc 5.974 -0.054 Td [(62\2617 )-3956(64\2618 )]TJ -0.0011 Tc 17.738 0.054 Td [(15\2612 )-3665(18\2613 )]TJ 11.04 -0.054 Td [(18\2614 )-2971(18\2614 )]TJ ET BT /Suspect <>BDC /T1_0 1 Tf -0.0097 Tc 9 0 0 9 56.122 335.284 Tm (PAEP: )Tj EMC ET BT /T1_0 1 Tf 0.0118 Tc 9 0 0 9 83.536 335.284 Tm (pulonary )Tj -0.0007 Tc 3.989 0 Td (alveolar )Tj 0.0043 Tc 3.519 0 Td (epithelial )Tj 0.0015 Tc 4.066 0 Td (permeability; )Tj 0 Tc 5.643 0 Td (T)Tj 6.2 0 0 6.2 244.26 331.44 Tm (0 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 6.2 0 0 6.2 249.5176 331.44 Tm (5)Tj 0.453 0.619 Td (: )Tj EMC ET BT /T1_0 1 Tf 0.0094 Tc 9 0 0 9 257.26 335.28 Tm (mean )Tj 0.003 Tc 2.508 0 Td (half-time )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0032 Tc 9 0 0 9 315.751 335.28 Tm (clearance; )Tj EMC ET BT /T1_0 1 Tf 0.0186 Tc 9 0 0 9 355.639 335.28 Tm (M\261so: )Tj 0.05 Tc 9.5784 0 0 9 383.02 335.28 Tm (mean\261 )Tj 0.0077 Tc 9 0 0 9 413.63 335.28 Tm (standard )Tj 0.0017 Tc 3.739 0 Td (deviation; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0051 Tc 9 0 0 9 486.629 335.28 Tm (CIPE: )Tj EMC ET BT /T1_0 1 Tf -0.0059 Tc 9 0 0 9 512.072 335.28 Tm (cardio-)Tj 0.0096 Tc -50.666 -1.119 Td (genic )Tj -0.0001 Tc 2.517 0 Td (pulmonary )Tj -0.0004 Tc 4.629 0 Td (oedema; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0006 Tc 9 0 0 9 154.556 325.209 Tm (U-ROI)Tj 0.31 g 0 Tc 2.749 0 Td (: )Tj EMC ET BT 0.188 0.188 0.184 rg /T1_0 1 Tf 0.0045 Tc 9 0 0 9 184.805 325.209 Tm (upper )Tj 0.0015 Tc 2.559 0 Td (region )Tj 0.05 Tc 9.4598 0 0 9 233.67 325.21 Tm (of )Tj -0.0066 Tc 9 0 0 9 244.73 325.21 Tm (interest; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0126 Tc 9 0 0 9 275.96 325.21 Tm (M-ROI: )Tj EMC ET BT /T1_0 1 Tf 0.0008 Tc 9 0 0 9 307.658 325.21 Tm (middle )Tj 0.0015 Tc 3.148 0 Td (region )Tj 0.05 Tc 9.4598 0 0 9 361.83 325.21 Tm (of )Tj -0.0066 Tc 9 0 0 9 372.41 325.21 Tm (interest; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0098 Tc 9 0 0 9 404.108 325.21 Tm (L-ROI: )Tj EMC ET BT /T1_0 1 Tf 0.0084 Tc 9 0 0 9 433.835 325.21 Tm (lower )Tj 0.0015 Tc 2.568 0 Td (region )Tj 0.05 Tc 10.0163 0 0 9 482.78 325.21 Tm (of )Tj -0.0099 Tc 9 0 0 9 493.85 325.21 Tm (interest. )Tj 0.0074 Tc 3.47 0 Td (For )Tj 0.0043 Tc -52.117 -1.067 Td (statistical )Tj -0.001 Tc 4.218 0 Td (analysis )Tj 0.0151 Tc 3.569 0 Td (see )Tj 0.0312 Tc 1.666 0 Td (the )Tj -0.0095 Tc 1.6 0 Td (text. )Tj 0.0341 Tc 2.131 0 Td (For )Tj 0 Tc 1.766 0 Td (p )Tj -0.008 Tc 0.903 0 Td (values )Tj 0.0151 Tc 2.921 0 Td (see )Tj -0.0136 Tc 1.663 0 Td (Results. )Tj 0 Tc 9.8 0 0 9.8 64.78 274.33 Tm (A )Tj 0.0093 Tc 1.114 0 Td (scintillation )Tj 0.0255 Tc 5.196 0 Td (count )Tj 0.0382 Tc 2.656 0 Td (by )Tj 0 Tc 1.409 0 Td (a )Tj 0.0152 Tc 0.833 0 Td (computerized )Tj 0.0279 Tc 5.929 0 Td (gamma )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0107 Tc 9.8 0 0 9.8 265.827 274.33 Tm (cam\255)Tj EMC ET BT /T1_0 1 Tf 0.0371 Tc 9.8 0 0 9.8 55.5876 263.7558 Tm (era )Tj 0.0089 Tc 1.772 0 Td (was )Tj -0.0011 Tc 2.105 0 Td (then )Tj 0.023 Tc 2.196 0 Td (carried )Tj 0.0329 Tc 3.381 0 Td (out )Tj 0.0196 Tc 1.81 0 Td (for )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.9497 0 0 9.8 182.28 263.76 Tm (30 )Tj EMC ET BT /T1_0 1 Tf 0.0089 Tc 9.8 0 0 9.8 197.26 263.76 Tm (min )Tj -0.0028 Tc 2.107 0 Td (with )Tj 0.0279 Tc 2.301 0 Td (the )Tj 0.0225 Tc 1.702 0 Td (subject )Tj 0.0125 Tc -20.571 -1.126 Td (sitting )Tj 0.0136 Tc 3.148 0 Td (with )Tj 0.0067 Tc 2.449 0 Td (his )Tj 0.0276 Tc 1.765 0 Td (back )Tj 0.009 Tc 2.544 0 Td (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0034 Tc 9.8 0 0 9.8 166.537 252.7252 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0279 Tc 9.8 0 0 9.8 184.2358 252.7252 Tm (gamma )Tj 0.012 Tc 3.622 0 Td (camera, )Tj -0.0012 Tc 3.818 0 Td (\(fig )Tj -0.0269 Tc 2.084 0 Td (1\) )Tj 0.0313 Tc -22.702 -1.079 Td (except )Tj -0.0048 Tc 3.232 0 Td (for )Tj 0.0194 Tc 1.581 0 Td (patients )Tj 0.05 Tc 10.0889 0 0 9.8 138.23 242.16 Tm (no )Tj 0 Tc 9.8 0 0 9.8 152.98 242.16 Tm (s )Tj 0.0071 Tc 0.91 0 Td (1, )Tj 0.049 Tc 1.157 0 Td (4, )Tj -0.0058 Tc 1.267 0 Td (and )Tj 0 Tc 1.91 0 Td (7 )Tj 0.0162 Tc 0.978 0 Td (\(multiple )Tj 0.0027 Tc 4.222 0 Td (trauma, )Tj 0.0054 Tc -20.375 -1.077 Td (table )Tj -0.016 Tc 2.465 0 Td (1\), )Tj 0.0238 Tc 1.454 0 Td (whose )Tj 0.0222 Tc 3.039 0 Td (body )Tj 0.0031 Tc 2.499 0 Td (position )Tj 0.0089 Tc 3.719 0 Td (was )Tj 0.0136 Tc 1.958 0 Td (maintained )Tj 0.0257 Tc 4.988 0 Td (at )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0008 Tc 9.8 0 0 9.8 263.9454 231.6054 Tm (+45\225. )Tj EMC ET BT /T1_0 1 Tf 0.0399 Tc 9.8 0 0 9.8 55.1172 220.5608 Tm (The )Tj 0.0168 Tc 2.057 0 Td (lung )Tj 0.0121 Tc 2.26 0 Td (radioactivity )Tj 0.0038 Tc 5.624 0 Td (data )Tj 0.0075 Tc 2.163 0 Td (were )Tj 0.0083 Tc 2.39 0 Td (framed )Tj 0.05 Tc 10.1194 0 0 9.8 229.82 220.57 Tm (at )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0165 Tc 9.8 0 0 9.8 241.81 220.57 Tm (30 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.8 0 0 9.8 255.6966 220.57 Tm (s )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0017 Tc 9.8 0 0 9.8 263.9188 220.57 Tm (inter\255)Tj EMC ET BT /T1_0 1 Tf 0.0206 Tc 9.8 0 0 9.8 55.1788 209.5156 Tm (vals )Tj 0.0432 Tc 2.049 0 Td (and )Tj 0.0093 Tc 1.91 0 Td (electronically )Tj 0.0194 Tc 5.939 0 Td (placed )Tj 0.0158 Tc 3.083 0 Td (regions )Tj 0.05 Tc 10.5727 0 0 9.8 215.9 209.52 Tm (of )Tj 0.0163 Tc 9.8 0 0 9.8 228.4 209.52 Tm (interest )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0043 Tc 9.8 0 0 9.8 261.9552 209.52 Tm (\(ROI\) )Tj EMC ET BT /T1_0 1 Tf 0.0075 Tc 9.8 0 0 9.8 55.185 198.9654 Tm (were )Tj 0.0131 Tc 2.877 0 Td (selected )Tj 0.049 Tc 3.728 0 Td (on )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0279 Tc 9.8 0 0 9.8 138.7006 198.9654 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0141 Tc 9.8 0 0 9.8 155.5174 198.9654 Tm (upper, )Tj 0.0143 Tc 3.035 0 Td (middle )Tj 0.0187 Tc 3.273 0 Td (and )Tj 0.0228 Tc 1.912 0 Td (lower )Tj 0.0128 Tc 2.74 0 Td (fields )Tj 0.05 Tc 10.5727 0 0 9.8 55.1 187.93 Tm (of )Tj 0.0173 Tc 9.8 0 0 9.8 67.58 187.93 Tm (each )Tj -0.0131 Tc 2.402 0 Td (lung. )Tj 0.0131 Tc 2.452 0 Td (Radioactivity )Tj 0.0089 Tc 6.029 0 Td (was )Tj 0.0157 Tc 1.999 0 Td (corrected )Tj 0.0196 Tc 4.26 0 Td (for )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0131 Tc 9.8 0 0 9.8 251.5162 187.93 Tm (radionu\255)Tj EMC ET BT /T1_0 1 Tf 0.0098 Tc 9.8 0 0 9.8 55.1046 176.8854 Tm (clide )Tj 0.02 Tc 3.136 0 Td (decay )Tj 0.0187 Tc 2.791 0 Td (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0279 Tc 9.8 0 0 9.8 131.9856 176.8854 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0201 Tc 9.8 0 0 9.8 147.7538 176.8854 Tm (data )Tj 0.0196 Tc 2.104 0 Td (for )Tj 0.0173 Tc 1.568 0 Td (each )Tj 0.0168 Tc 2.255 0 Td (lung )Tj 0.0187 Tc 2.202 0 Td (and )Tj 0.0173 Tc 1.861 0 Td (each )Tj 0.0223 Tc 2.258 0 Td (ROI )Tj 0.0075 Tc -21.694 -1.127 Td (were )Tj 0.029 Tc 2.403 0 Td (plotted )Tj 0.049 Tc 3.368 0 Td (on )Tj 0 Tc 1.566 0 Td (a )Tj 0.0105 Tc 0.927 0 Td (semi-logarithmic )Tj 0.0096 Tc 7.494 0 Td (scale )Tj 0.0201 Tc 2.502 0 Td (against )Tj 0.0135 Tc 3.437 0 Td (time )Tj 0.0228 Tc -21.753 -1.128 Td (in )Tj 0 Tc 1.173 0 Td (a )Tj 0.0089 Tc 1.227 0 Td (linear )Tj 0.0064 Tc 2.643 0 Td (co-ordinate. )Tj 0.0399 Tc 5.243 0 Td (The )Tj 0.0016 Tc 1.956 0 Td (following )Tj 0.0047 Tc 4.313 0 Td (indices )Tj 0.0239 Tc 3.191 0 Td (were )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0022 Tc 9.8 0 0 9.8 271.0966 154.7864 Tm (cal\255)Tj EMC ET BT /T1_0 1 Tf -0.0008 Tc 9.8 0 0 9.8 54.6146 143.7418 Tm (culated: )Tj 0.0034 Tc 3.584 0 Td (the )Tj 0.0152 Tc 1.567 0 Td (mean )Tj 0.0022 Tc 2.597 0 Td (half-time )Tj 0.0091 Tc 4.007 0 Td (clearance )Tj ET BT /Suspect <>BDC /T1_3 1 Tf -0.035 Tc 8.1819 0 0 9.9 210.56 143.76 Tm (\(fo.s\225 )Tj EMC ET BT /T1_0 1 Tf -0.0066 Tc 9.8 0 0 9.8 230.38 143.76 Tm (min\), )Tj 0.0033 Tc 2.45 0 Td (referred )Tj 0.009 Tc -20.328 -1.077 Td (to )Tj 0.0034 Tc 1.224 0 Td (the )Tj 0.0121 Tc 1.714 0 Td (monoexponential )Tj 0.0117 Tc 7.593 0 Td (regression )Tj 0.0079 Tc 4.695 0 Td (line, )Tj 0.0029 Tc 2.26 0 Td (which )Tj 0.0033 Tc 2.929 0 Td (follows )Tj 0.0034 Tc -20.464 -1.128 Td (the )Tj 0.0147 Tc 1.904 0 Td (initial )Tj 0.0193 Tc 3.096 0 Td (peak, )Tj 0.0187 Tc 2.829 0 Td (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0034 Tc 9.8 0 0 9.8 153.0972 122.151 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0213 Tc 9.8 0 0 9.8 171.2566 122.151 Tm (clearance )Tj 0.0239 Tc 4.564 0 Td (rate )Tj -0.0009 Tc 2.242 0 Td (\(K\), )Tj -0.0094 Tc 2.362 0 Td (which )Tj 0.0181 Tc -21.119 -1.127 Td (expressed )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0034 Tc 9.8 0 0 9.8 101.2552 111.1064 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0178 Tc 9.8 0 0 9.8 120.3358 111.1064 Tm (slope )Tj 0.05 Tc 10.5727 0 0 9.8 148.7 111.12 Tm (of )Tj -0.0067 Tc 9.8 0 0 9.8 164.14 111.12 Tm (this )Tj 0.0285 Tc 2.149 0 Td (line )Tj 0.0117 Tc 2.251 0 Td (as )Tj 0.0279 Tc 1.576 0 Td (the )Tj 0.0102 Tc 1.963 0 Td (percentage )Tj 0.0141 Tc -19.162 -1.077 Td (decrease )Tj 0.0277 Tc 3.881 0 Td (per )Tj 0.0143 Tc 1.661 0 Td (minute )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0029 Tc 9.8 0 0 9.8 139.5616 100.5654 Tm (\(%\267min\267)Tj 0.31 g /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 171.16 103.44 Tm (1)Tj 0.188 0.188 0.184 rg 0.05 Tc 9.1299 0 0 6.2 173.6 100.57 Tm (\). )Tj EMC ET BT /T1_0 1 Tf 0.019 Tc 9.8 0 0 9.8 183.3 100.57 Tm (Every )Tj 0.0225 Tc 2.735 0 Td (subject )Tj 0.0089 Tc 3.246 0 Td (was )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0141 Tc 9.8 0 0 9.8 260.5436 100.57 Tm (evalu\255)Tj EMC ET BT /T1_0 1 Tf 0.0208 Tc 9.8 0 0 9.8 54.1458 89.5156 Tm (ated )Tj 0.0099 Tc 2.107 0 Td (once. )Tj /T1_3 1 Tf 0.0068 Tc 9.9 0 0 9.9 307.18 273.84 Tm (Statistical )Tj 0.0183 Tc 4.408 0 Td (analysis )Tj /T1_0 1 Tf 0.0399 Tc 9.8 0 0 9.8 316.24 250.33 Tm (The )Tj 0.0126 Tc 1.953 0 Td (statistical )Tj 0.0089 Tc 4.31 0 Td (significance )Tj 0.05 Tc 11.1292 0 0 9.8 429.01 250.33 Tm (of )Tj 0.0078 Tc 9.8 0 0 9.8 441.51 250.33 Tm (differences )Tj 0.0228 Tc 4.899 0 Td (in )Tj 0.0083 Tc 1.183 0 Td (half-time )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.6416 0 0 9.5 307.1 239.29 Tm (\(fo.s\) )Tj EMC ET BT /T1_0 1 Tf 0.0187 Tc 9.8 0 0 9.8 328.22 239.29 Tm (and )Tj 0.0152 Tc 1.91 0 Td (clearance )Tj 0.0239 Tc 4.27 0 Td (rate )Tj 0.0257 Tc 1.948 0 Td (\(K\) )Tj 0.0158 Tc 1.865 0 Td (inside )Tj 0.0169 Tc 2.841 0 Td (groups )Tj -0.0058 Tc 3.231 0 Td (and )Tj 0.002 Tc 1.872 0 Td (between )Tj 0.0071 Tc -20.091 -1.078 Td (groups )Tj 0.0151 Tc 3.289 0 Td (had )Tj 0.0113 Tc 1.961 0 Td (been )Tj 0.0197 Tc 2.401 0 Td (performed )Tj 0.0219 Tc 4.798 0 Td (using )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0279 Tc 9.8 0 0 9.8 455.9728 228.7256 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.011 Tc 9.8 0 0 9.8 472.8092 228.7256 Tm (parametric )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.005 Tc 9.8 0 0 9.8 520.6136 228.7256 Tm (Stu\255)Tj EMC ET BT /T1_0 1 Tf 0.0436 Tc 9.8 0 0 9.8 307.101 217.681 Tm (dent's )Tj 0.0127 Tc 2.946 0 Td (t-test )Tj 0.018 Tc 2.441 0 Td (applied )Tj -0.035 Tc 9.7344 0 0 10.3 394.54 217.69 Tm (to )Tj 0.0129 Tc 9.8 0 0 9.8 406 217.69 Tm (independent )Tj 0.005 Tc 5.431 0 Td (samples. )Tj 0.0399 Tc 3.924 0 Td (The )Tj 0.0086 Tc 2.057 0 Td (level )Tj 0.05 Tc 10.0163 0 0 9.8 307.1 206.65 Tm (of )Tj 0.0126 Tc 9.8 0 0 9.8 320.98 206.65 Tm (statistical )Tj 0.0178 Tc 4.506 0 Td (significance )Tj 0.0334 Tc 5.548 0 Td (was )Tj 0.0172 Tc 2.195 0 Td (chosen )Tj 0.0257 Tc 3.478 0 Td (at )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.0431 0 0 9.8 487.69 206.65 Tm (p>BDC /T1_0 1 Tf 0.0231 Tc 9.8 0 0 9.8 336.924 151.9312 Tm (PAEP )Tj EMC /Suspect <>BDC /T1_3 1 Tf -0.035 Tc 7.0914 0 0 9.9 367.58 151.93 Tm (fo.s )Tj EMC ET BT /T1_0 1 Tf 0.0197 Tc 9.8 0 0 9.8 382.54 151.93 Tm (values )Tj 0.05 Tc 10.5727 0 0 9.8 413.18 151.93 Tm (of )Tj 0.0262 Tc 9.8 0 0 9.8 427.1 151.93 Tm (Group )Tj 0.0216 Tc 3.183 0 Td (3, )Tj 0.0048 Tc 1.332 0 Td (mean\261so )Tj -0.0058 Tc 4.204 0 Td (and )Tj 0 Tc 1.971 0 Td (p )Tj 0.0099 Tc -22.927 -1.078 Td (values )Tj 0.0196 Tc 3.028 0 Td (for )Tj 0.0173 Tc 1.617 0 Td (each )Tj 0.0168 Tc 2.304 0 Td (lung )Tj 0.0187 Tc 2.251 0 Td (and )Tj 0.0173 Tc 1.91 0 Td (each )Tj 0.014 Tc 2.31 0 Td (vertical )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0223 Tc 9.8 0 0 9.8 473.2188 141.3656 Tm (ROI )Tj EMC ET BT /T1_0 1 Tf 0.0328 Tc 9.8 0 0 9.8 494.2888 141.3656 Tm (are )Tj 0.0025 Tc 1.71 0 Td (shown )Tj -0.0262 Tc -20.81 -1.079 Td (in )Tj 0.0176 Tc 1.182 0 Td (table )Tj -0.0234 Tc 2.396 0 Td (2; )Tj -0.0011 Tc 1.229 0 Td (they )Tj 0.0328 Tc 2.147 0 Td (are )Tj 0.0034 Tc 1.722 0 Td (the )Tj 0.0133 Tc 1.617 0 Td (reference )Tj 0.0099 Tc 4.26 0 Td (values )Tj 0.05 Tc 10.0163 0 0 9.8 479.42 130.8 Tm (of )Tj 0.0294 Tc 9.8 0 0 9.8 491.43 130.8 Tm (our )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0037 Tc 9.8 0 0 9.8 509.1974 130.8 Tm (labora\255)Tj EMC ET BT /T1_0 1 Tf 0.0009 Tc 9.8 0 0 9.8 306.7 119.7554 Tm (tory. )Tj 0.05 Tc 9.9723 0 0 9.8 331.11 119.76 Tm (The )Tj 0.019 Tc 9.8 0 0 9.8 353.18 119.76 Tm (corresponding )Tj 0.0176 Tc 6.559 0 Td (single )Tj 0.0099 Tc 3.098 0 Td (values )Tj -0.0262 Tc 3.276 0 Td (in )Tj 0.0319 Tc 1.369 0 Td (CIPO )Tj -0.0058 Tc 2.988 0 Td (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0112 Tc 9.8 0 0 9.8 306.6986 108.7154 Tm (ARDS )Tj EMC ET BT /T1_0 1 Tf 0.0124 Tc 9.8 0 0 9.8 337.4608 108.7154 Tm (patients )Tj 0.0328 Tc 3.563 0 Td (are )Tj 0.0148 Tc 1.661 0 Td (shown )Tj 0.0228 Tc 3.043 0 Td (in )Tj 0.0176 Tc 1.182 0 Td (table )Tj 0.0216 Tc 2.391 0 Td (3. )Tj 0.0399 Tc 1.13 0 Td (The )Tj 0.0201 Tc 2.007 0 Td (data )Tj 0.0037 Tc 2.105 0 Td (analysis )Tj 0.018 Tc -20.233 -1.127 Td (shows )Tj 0.0079 Tc 3 0 Td (that )Tj ET BT /Suspect <>BDC /T1_3 1 Tf -0.035 Tc 7.0914 0 0 9.9 355.1 97.68 Tm (fo.s )Tj EMC ET BT /T1_0 1 Tf 0.0239 Tc 9.8 0 0 9.8 368.62 97.68 Tm (value )Tj 0.0127 Tc 2.638 0 Td (differences )Tj 0.0196 Tc 4.945 0 Td (for )Tj 0.015 Tc 1.568 0 Td (corresponding )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0223 Tc 9.8 0 0 9.8 519.3146 97.68 Tm (ROI )Tj EMC ET BT /T1_0 1 Tf 0.0075 Tc 9.8 0 0 9.8 306.7134 87.1156 Tm (were )Tj 0.019 Tc 2.694 0 Td (highly )Tj 0.0168 Tc 3.415 0 Td (significant )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.6627 0 0 9.8 416.53 87.12 Tm (\(p>BDC /T1_0 1 Tf 0.0155 Tc 9.8 0 0 9.8 492.384 87.12 Tm (CIPO )Tj EMC ET BT /T1_0 1 Tf 0.0187 Tc 9.8 0 0 9.8 522.1466 87.12 Tm (and )Tj ET endstream endobj 9 0 obj <>stream jP ftypjp2 jp2 jpxbjpx rreq@ .-jp2hihdrcolrujp2cOQ)R \#B@HHPHHPHHPHHP((( v4V|󁌋s1SRQq%0yP0zX@X1#al.ڻicu+KǣnD.)j(3WUP`[#'_+laТp?f9\#+@l;j%Cبvyű Xԡ_AƐ8mnVtWDz* l-k2^690t#)u2uDHf@%I"3l7WDkhqN `ɕ!Sq$:j{m܎ݫLuM0,/ar9D Ӵ!ֳA:$b!)ec."$ 59_U Vú`H\uf} [a%HRp2U{~8[}pUePk[C<;&x qs5a:[lTۉ}δu!!/>#Ӳ8`:xo aI}HwrDR!;Fj r 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(PERMEABILITY )Tj EMC /Suspect <>BDC 0.282 g 0 Tc 7.918 0 Td (I)Tj 0.443 g 0.371 0 Td (N )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg -0.0054 Tc 1.191 0 Td (PUI.MONARY )Tj EMC /Suspect <>BDC 0.443 g 0.0014 Tc 6.834 0 Td (OEDEMA )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_0 1 Tf -0.035 Tc 8.882 0 0 9.6 514.94 765.37 Tm (921 )Tj /T1_1 1 Tf -0.0065 Tc 9.4 0 0 9.4 49.45 739.93 Tm (ARDS )Tj -0.0286 Tc 3.248 0 Td (patients )Tj -0.035 Tc 9.0921 0 0 9.4 115.2 739.93 Tm (were )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.0332 Tc 9.4 0 0 9.4 137.65 739.93 Tm (compared. )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg 0.0342 Tc -8.468 -1.174 Td (With )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 9.2771 0 0 9.4 82.38 728.89 Tm (respect )Tj 0.282 g -0.0085 Tc 9.4 0 0 9.4 115.64 728.89 Tm (to )Tj 0.365 0.365 0.361 rg -0.0222 Tc 1.262 0 Td (non )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0056 Tc 9.4 0 0 9.4 146.707 728.89 Tm (mokmg )Tj EMC ET BT /T1_1 1 Tf -0.0242 Tc 9.4 0 0 9.4 181.7502 728.89 Tm (normals )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.0169 Tc 9.4 0 0 9.4 218.3444 728.89 Tm ({table )Tj EMC ET BT /T1_1 1 Tf -0.0016 Tc 9.7 0 0 9.7 244.72 728.89 Tm (2\), )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0256 Tc 9.7 0 0 9.7 260.4534 728.89 Tm (bolh )Tj EMC ET BT 0.443 g /T1_0 1 Tf -0.035 Tc 9.2939 0 0 10.2 48.86 718.33 Tm (CTPO )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf 8.8407 0 0 9.9 75.27 718.33 Tm (and )Tj EMC /Suspect <>BDC -0.0235 Tc 9.4 0 0 9.4 93.61 718.33 Tm (ARDS )Tj EMC ET BT /T1_1 1 Tf -0.0335 Tc 9.4 0 0 9.4 123.267 718.33 Tm (groups )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.035 Tc 9.1164 0 0 9.4 153.91 718.33 Tm (recorded )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_0 1 Tf 10.1679 0 0 10.2 191.42 718.33 Tm (an )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 9.0677 0 0 9.4 204.78 718.33 Tm (increase )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 10.5806 0 0 9.4 239.9 718.33 Tm (of )Tj -0.0114 Tc 9.4 0 0 9.4 251.31 718.33 Tm (PAEP, )Tj -0.035 Tc 8.4894 0 0 9.4 49.26 707.28 Tm (Lhis )Tj -0.0163 Tc 9.4 0 0 9.4 68.94 707.28 Tm (being )Tj -0.0207 Tc 2.92 0 Td (greater )Tj 0.0282 Tc 3.565 0 Td (in )Tj -0.0065 Tc 1.399 0 Td (ARDS )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 8.8749 0 0 9.4 175.04 707.28 Tm (\(p>BDC /T1_0 1 Tf -0.0059 Tc 9.6 0 0 9.6 220.3 707.28 Tm (than )Tj EMC /Suspect <>BDC 0.443 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 242.7 707.28 Tm (i)Tj 0.282 g 0.255 0 Td (n )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 0.012 Tc 9.4 0 0 9.4 255.2208 707.28 Tm (CIPO )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.0277 Tc 9.4 0 0 9.4 48.778 696.2538 Tm (patients. )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0079 Tc 9.4 0 0 9.4 85.7106 696.2538 Tm (PAEP )Tj ET BT /Suspect <>BDC 0.443 g /T1_0 1 Tf -0.035 Tc 9.4494 0 0 10 113.17 696.25 Tm (\(leu\) )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0229 Tc 9.4 0 0 9.4 133.26 696.25 Tm (in )Tj 0.0133 Tc 1.128 0 Td (ClPO )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0286 Tc 9.4 0 0 9.4 169.7414 696.25 Tm (p:ujents )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 9.0865 0 0 9.4 203.82 696.25 Tm (increased )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0063 Tc 9.4 0 0 9.4 243.67 696.25 Tm (\(p<0.05\) )Tj EMC ET BT /T1_1 1 Tf 0.0044 Tc 9.4 0 0 9.4 49.4378 685.2144 Tm (with )Tj 0.443 g -0.035 Tc 8.8804 0 0 9.4 70.39 685.21 Tm (respec)Tj 0.282 g 0 Tc 9.4 0 0 9.4 95.48 685.21 Tm (t )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0033 Tc 8.3 0 0 8.3 101.47 685.21 Tm (10 )Tj EMC ET BT /T1_1 1 Tf -0.0333 Tc 9.4 0 0 9.4 113.1 685.21 Tm (nonsmoldng )Tj -0.0242 Tc 5.515 0 Td (normals )Tj 0.443 g -0.035 Tc 9.0913 0 0 9.4 200.07 685.21 Tm (on)Tj 0.282 g 0.05 Tc 9.8395 0 0 9.4 210.06 685.21 Tm (ly )Tj 0.365 0.365 0.361 rg -0.0229 Tc 9.4 0 0 9.4 221.58 685.21 Tm (in )Tj -0.035 Tc 9.1495 0 0 9.4 232.28 685.21 Tm (the )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0122 Tc 9.4 0 0 9.4 247.98 685.21 Tm (middle\255)Tj EMC ET BT 0.282 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 49.264 674.6538 Tm (l)Tj 0.443 g 0.0382 Tc 0.316 0 Td (owe)Tj 0.282 g 0 Tc 1.88 0 Td (r )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf 0.05 Tc 9.6089 0 0 9.4 79.94 674.65 Tm (ROI )Tj EMC ET BT 0.443 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 104.07 674.65 Tm (o)Tj 0.282 g 0.671 0 Td (f )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf 0.0091 Tc 9.4 0 0 9.4 119.815 674.65 Tm (both )Tj EMC ET BT 0.282 g /T1_1 1 Tf 0.0472 Tc 9.4 0 0 9.4 145.2514 674.65 Tm (lung)Tj 0.443 g 0 Tc 2.053 0 Td (s )Tj 0.05 Tc 9.4002 0 0 9.4 175.03 674.65 Tm (\(whole )Tj 0.365 0.365 0.361 rg 9.6961 0 0 9.4 211.02 674.65 Tm (right )Tj 0.282 g 0.0472 Tc 9.4 0 0 9.4 237.9 674.65 Tm (lung )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 263.4774 674.65 Tm (t)Tj 0.443 g /T1_0 1 Tf 6.4001 0 0 6.4001 265.86 671.77 Tm (0)Tj 0.71 g 0.664 0.45 Td (.)Tj 0.443 g 0.231 -0.527 Td (5)Tj 0.598 0.527 Td (, )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0004 Tc 9.4 0 0 9.4 48.78 663.6 Tm (mean\261so, )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 96.344 663.6 Tm (C)Tj 0.282 g 0.0355 Tc 0.804 0 Td (IPO)Tj 0.443 g 0 Tc 1.788 0 Td (: )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 0.0341 Tc 9.4 0 0 9.4 129.4978 663.6 Tm (62\2619, )Tj 0.0053 Tc 3.362 0 Td (normals: )Tj 0.443 g 0.0027 Tc 4.603 0 Td (85\26134 )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0237 Tc 9.4 0 0 9.4 237.908 663.6 Tm (\(p<0.05\); )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 0.0083 Tc 9.4 0 0 9.4 49.2594 652.5738 Tm (middle-lower )Tj 0.0157 Tc 6.332 0 Td (right )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0058 Tc 9.4 0 0 9.4 133.2202 652.5738 Tm (ROI, )Tj EMC /Suspect <>BDC 0.443 g -0.0092 Tc 2.664 0 Td (CIPO: )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 0.0156 Tc 9.4 0 0 9.4 189.0186 652.5738 Tm (62\2617-64\2618, )Tj 0.282 g 0 Tc 5.762 0 Td (n)Tj 0.443 g -0.0235 Tc 0.52 0 Td (ormals: )Tj 0.365 0.365 0.361 rg 0.0123 Tc -21.194 -1.176 Td (89\26137-85\26134 )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 110.7072 641.5194 Tm (\()Tj 0.282 g 0.356 0 Td (p)Tj 0.443 g -0.0096 Tc 0.565 0 Td (<0.05\)\). )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0119 Tc 9.4 0 0 9.4 156.41 641.5194 Tm (The )Tj -0.035 Tc 9.126 0 0 9.4 177.51 641.52 Tm (apex-base )Tj -0.0164 Tc 9.4 0 0 9.4 222.63 641.52 Tm (gradient, )Tj -0.035 Tc 9.1495 0 0 9.4 263.48 641.52 Tm (tha)Tj 0.2 g 0 Tc 9.4 0 0 9.4 275.48 641.52 Tm (t )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.0091 0 0 9.4 48.96 630.96 Tm (was )Tj -0.0328 Tc 9.4 0 0 9.4 69.51 630.96 Tm (demonstrated )Tj -0.0229 Tc 6.322 0 Td (in )Tj -0.0158 Tc 1.328 0 Td (nonsmoking )Tj 0.443 g -0.0321 Tc 5.781 0 Td (subjects )Tj 0.282 g -0.0029 Tc 3.921 0 Td (by )Tj -0.035 Tc 8.815 0 0 9.4 247.52 630.96 Tm (us )Tj 0.365 0.365 0.361 rg -0.0209 Tc 9.4 0 0 9.4 261.89 630.96 Tm ([29\) )Tj -0.035 Tc 8.8407 0 0 9.4 48.87 619.93 Tm (and )Tj -0.0305 Tc 9.4 0 0 9.4 67.11 619.93 Tm (others )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 95.6954 619.93 Tm (1)Tj 0.443 g -0.0184 Tc 0.33 0 Td (20, )Tj EMC /Suspect <>BDC -0.0206 Tc 1.733 0 Td (30}, )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 9.0091 0 0 9.4 134.88 619.93 Tm (was )Tj -0.0278 Tc 9.4 0 0 9.4 153.98 619.93 Tm (abolished )Tj 0.2 g 0.0282 Tc 4.485 0 Td (in )Tj 0.365 0.365 0.361 rg -0.025 Tc 1.174 0 Td (both )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf -0.035 Tc 8.5004 0 0 9.4 229.4 619.93 Tm (th)Tj 0.443 g 8.5362 0 0 9.4 236.55 619.93 Tm (ese )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg 8.95 0 0 9.4 253.27 619.93 Tm (pat)Tj 0.2 g 0 Tc 9.4 0 0 9.4 265.26 619.93 Tm (h)Tj 0.365 0.365 0.361 rg 0.0001 Tc 0.52 0 Td (o\255)Tj EMC ET BT /T1_1 1 Tf 0.0025 Tc 9.4 0 0 9.4 49.2574 609.3738 Tm (logical )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.02 Tc 9.4 0 0 9.4 80.0518 609.3738 Tm (co)Tj 0.282 g 0.0095 Tc 1.065 0 Td (ndition)Tj 0.443 g 0 Tc 3.023 0 Td (s )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0196 Tc 9.4 0 0 9.4 126.5536 609.3738 Tm (\(tab)Tj 0.2 g 0 Tc 1.684 0 Td (l)Tj 0.365 0.365 0.361 rg 0.264 0 Td (e )Tj -0.035 Tc 9.2771 0 0 9.4 153.97 609.37 Tm (3\) )Tj 8.1801 0 0 9.4 166.48 609.37 Tm (as )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0113 Tc 9.4 0 0 9.4 179.52 609.37 Tm (well )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 7.6989 0 0 9.4 200.56 609.37 Tm (as )Tj 0.282 g -0.0229 Tc 9.4 0 0 9.4 213.42 609.37 Tm (in )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 8.7835 0 0 9.4 225.56 609.37 Tm (the )Tj EMC ET BT 0.443 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 241.36 609.37 Tm (s)Tj 0.282 g -0.021 Tc 0.449 0 Td (moker)Tj 0.443 g 0.0456 Tc 2.666 0 Td (s' )Tj 0.282 g -0.0341 Tc -23.551 -1.174 Td (lun)Tj 0.443 g -0.035 Tc 8.7163 0 0 9.4 61.36 598.33 Tm (gs )Tj 0.365 0.365 0.361 rg -0.0142 Tc 9.4 0 0 9.4 74.23 598.33 Tm (\(table )Tj 0.443 g -0.009 Tc 2.818 0 Td (2\). )Tj 0.2 g 0.05 Tc 9.5503 0 0 9.4 141.38 576.72 Tm (Di)Tj 0.365 0.365 0.361 rg -0.035 Tc 8.6414 0 0 9.4 151.13 576.72 Tm (sc)Tj 0.2 g 0 Tc 9.4 0 0 9.4 159.66 576.72 Tm (u)Tj 0.365 0.365 0.361 rg -0.035 Tc 8.1331 0 0 9.4 165.05 576.72 Tm (ss)Tj 0.2 g -0.0086 Tc 9.4 0 0 9.4 173.1 576.72 Tm (ion )Tj 0.365 0.365 0.361 rg -0.0065 Tc -12.286 -2.297 Td (ARDS )Tj -0.0179 Tc 3.248 0 Td (is )Tj 0.282 g /T1_0 1 Tf 0 Tc 10.9 0 0 10.9 98.29 555.13 Tm (a )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.025 Tc 9.4 0 0 9.4 107.34 555.13 Tm (life-thr)Tj 0.443 g -0.035 Tc 8.6589 0 0 9.4 134.31 555.13 Tm (ea)Tj 0.282 g 0 Tc 9.4 0 0 9.4 143.96 555.13 Tm (t)Tj 0.443 g -0.0183 Tc 0.249 0 Td (ening )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0051 Tc 9.4 0 0 9.4 172.1412 555.13 Tm (pulmonary )Tj ET BT /Suspect <>BDC 0.282 g /T1_0 1 Tf -0.035 Tc 10.5507 0 0 15.2 219.34 555.13 Tm (rusease )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 0.0215 Tc 9.4 0 0 9.4 252 555.13 Tm (with )Tj 0.282 g 0 Tc 2.236 0 Td (a )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0158 Tc 9.4 0 0 9.4 48.302 544.5738 Tm (rapid)Tj 0.2 g 0 Tc 2.247 0 Td (l)Tj 0.365 0.365 0.361 rg 0.321 0 Td (y )Tj EMC ET BT 0.282 g /T1_1 1 Tf 0.0109 Tc 9.4 0 0 9.4 81.8976 544.5738 Tm (pr)Tj 0.443 g -0.035 Tc 9.0697 0 0 9.4 90.15 544.57 Tm (ogress)Tj 0.282 g 0.05 Tc 9.8395 0 0 9.4 115.97 544.57 Tm (iv)Tj 0.443 g 0 Tc 9.4 0 0 9.4 123.74 544.57 Tm (e )Tj 0.365 0.365 0.361 rg -0.0035 Tc 0.971 0 Td (decline )Tj -0.0266 Tc 3.574 0 Td (due )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0101 Tc 9.4 0 0 9.4 186.0526 544.57 Tm (mrunly )Tj EMC ET BT 0.2 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 218.351 544.57 Tm (t)Tj 0.365 0.365 0.361 rg 0.301 0 Td (o )Tj 0.282 g -0.0008 Tc 1.063 0 Td (multi-organ )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0223 Tc 9.4 0 0 9.4 48.9348 533.5156 Tm (frulure. )Tj EMC /Suspect <>BDC -0.035 Tc 9.2607 0 0 9.4 82.35 533.52 Tm (Death )Tj EMC ET BT 0.443 g /T1_1 1 Tf 0.0009 Tc 9.4 0 0 9.4 110.31 533.52 Tm (occu)Tj 0.282 g 0 Tc 2.033 0 Td (r)Tj 0.443 g 0.368 0 Td (s )Tj 0.365 0.365 0.361 rg 0.0282 Tc 0.909 0 Td (in )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0.0306 Tc 9.4 0 0 9.4 153.4936 533.52 Tm (50-75% )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 0.05 Tc 10.5806 0 0 9.4 191.42 533.52 Tm (of )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0065 Tc 9.4 0 0 9.4 204.49 533.52 Tm (ARDS )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 8.5948 0 0 9.4 235.58 533.52 Tm (cases )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 8.733 0 0 9.4 261.91 533.52 Tm ([30J )Tj EMC ET BT /T1_1 1 Tf 8.8407 0 0 9.4 48.39 522.96 Tm (and )Tj 0.0282 Tc 9.4 0 0 9.4 67.5 522.96 Tm (in )Tj -0.0145 Tc 1.226 0 Td (more )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf -0.035 Tc 9.1676 0 0 9.4 104.12 522.96 Tm (than )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf 10.4943 0 0 10.5 125.16 522.96 Tm (90% )Tj EMC ET BT /T1_1 1 Tf 9.2553 0 0 9.4 148.32 522.96 Tm (when )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0235 Tc 9.4 0 0 9.4 174.25 522.96 Tm (ARDS )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 8.9061 0 0 9.4 204.79 522.96 Tm (is )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 9.1881 0 0 9.4 214.95 522.96 Tm (associated )Tj EMC /Suspect <>BDC 0.0215 Tc 9.4 0 0 9.4 260.64 522.96 Tm (with )Tj EMC /Suspect <>BDC 0.443 g -0.0309 Tc -22.579 -1.173 Td (septicaemia )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg 0.0044 Tc 5.605 0 Td ([31\). )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.679 0 0 9.6 125.2 511.93 Tm (The )Tj EMC /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.035 Tc 8.8255 0 0 9.4 145.84 511.93 Tm (searc)Tj 0.282 g 0 Tc 9.4 0 0 9.4 166.38 511.93 Tm (h )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 0.026 Tc 9.4 0 0 9.4 176.6166 511.93 Tm (for )Tj /T1_0 1 Tf 0 Tc 10.9 0 0 10.9 192.85 511.93 Tm (a )Tj /T1_1 1 Tf -0.0009 Tc 9.4 0 0 9.4 202.38 511.93 Tm (predictive )Tj -0.022 Tc 4.8 0 Td (marker, )Tj -0.0146 Tc -21.192 -1.176 Td (useful )Tj 0.282 g 0.0282 Tc 3.115 0 Td (in )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 7.6665 0 0 9.4 90.08 500.88 Tm (Lhe )Tj EMC ET BT /T1_1 1 Tf -0.0124 Tc 9.4 0 0 9.4 106.46 500.88 Tm (early )Tj -0.0198 Tc 2.605 0 Td (diagnosis )Tj 0.05 Tc 10.5806 0 0 9.4 173.18 500.88 Tm (of )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.0103 Tc 9.4 0 0 9.4 186.73 500.88 Tm (ARDS, )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0179 Tc 9.4 0 0 9.4 220.1376 500.88 Tm (is )Tj 0.0242 Tc 1.054 0 Td (justified )Tj -0.0029 Tc 4.052 0 Td (by )Tj 0.0057 Tc -23.336 -1.123 Td (its )Tj -0.0037 Tc 1.379 0 Td (high )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0116 Tc 9.4 0 0 9.4 82.86 490.3238 Tm (mortality )Tj EMC /Suspect <>BDC -0.035 Tc 8.8257 0 0 9.4 123.19 490.32 Tm (rates )Tj EMC ET BT /T1_1 1 Tf -0.0127 Tc 9.4 0 0 9.4 145.92 490.32 Tm (which )Tj -0.035 Tc 9.2339 0 0 9.4 173.18 490.32 Tm (are )Tj 0.0151 Tc 9.4 0 0 9.4 188.94 490.32 Tm (not )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.016 Tc 9.4 0 0 9.4 205.2584 490.32 Tm (predictable )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 10.1631 0 0 10.8 252.86 490.32 Tm (on )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0162 Tc 9.6 0 0 9.6 266.86 490.32 Tm (the )Tj EMC /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.035 Tc 8.8801 0 0 9.4 48.79 479.29 Tm (basis )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 0.05 Tc 10.5806 0 0 9.4 71.9 479.29 Tm (of )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0012 Tc 9.4 0 0 9.4 84.48 479.29 Tm (well-known )Tj EMC /Suspect <>BDC 0.443 g 0.0112 Tc 5.35 0 Td (clinical )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 9.1881 0 0 9.4 167.35 479.29 Tm (roen)Tj 0.282 g 0 Tc 9.4 0 0 9.4 185.24 479.29 Tm (t)Tj 0.443 g -0.0316 Tc 0.25 0 Td (genographic )Tj 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0101 Tc 10.2 0 0 10.2 239.9 479.29 Tm (and )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0212 Tc 9.4 0 0 9.4 258.22 479.29 Tm (func\255)Tj EMC ET BT /T1_1 1 Tf -0.0065 Tc 9.4 0 0 9.4 48.9196 468.7338 Tm (tional )Tj 0.443 g 0.0041 Tc 2.75 0 Td (criteria )Tj 0.365 0.365 0.361 rg 0.0359 Tc 3.465 0 Td (l32]. )Tj -0.0119 Tc 2.413 0 Td (The )Tj -0.035 Tc 9.3139 0 0 9.4 149.58 468.73 Tm (present )Tj 0.443 g -0.0176 Tc 9.4 0 0 9.4 181.84 468.73 Tm (study )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 9.3632 0 0 9.4 207.27 468.73 Tm (demonstrates )Tj EMC ET BT /T1_1 1 Tf 8.9602 0 0 9.4 263.96 468.73 Tm (that )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0065 Tc 9.4 0 0 9.4 48.97 457.69 Tm (ARDS )Tj EMC ET BT /T1_1 1 Tf -0.0179 Tc 9.4 0 0 9.4 79.9806 457.69 Tm (is )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.035 Tc 9.1881 0 0 9.4 91.59 457.69 Tm (associated )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg 0.0215 Tc 9.4 0 0 9.4 137.76 457.69 Tm (with )Tj EMC ET BT /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 159.7372 457.69 Tm (a )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0.0102 Tc 9.4 0 0 9.4 168.874 457.69 Tm (striking )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 9.3425 0 0 9.4 204.3 457.69 Tm (increase )Tj /T1_0 1 Tf 9.2582 0 0 10.1 241.84 457.69 Tm (in )Tj /T1_1 1 Tf -0.0249 Tc 9.4 0 0 9.4 254.19 457.69 Tm (PAEP )Tj 0.0001 Tc -21.884 -1.174 Td (which )Tj -0.0179 Tc 3.147 0 Td (is )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0.0226 Tc 9.4 0 0 9.4 88.7218 446.6544 Tm (significanlly )Tj EMC ET BT 0.282 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 144.304 446.6544 Tm (h)Tj 0.443 g -0.0208 Tc 0.511 0 Td (ighe)Tj 0.282 g 0 Tc 1.838 0 Td (r )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.035 Tc 8.2481 0 0 9.4 174.1 446.65 Tm (\(p>BDC /T1_1 1 Tf -0.035 Tc 9.1311 0 0 9.4 158.31 435.6 Tm (data, )Tj EMC ET BT 0.282 g /T1_1 1 Tf -0.0249 Tc 9.4 0 0 9.4 180.75 435.6 Tm (PAEP )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.1671 0 0 9.4 208.62 435.6 Tm (may )Tj 9.1853 0 0 9.9 228.78 435.6 Tm (be )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 9.2061 0 0 9.4 241.74 435.6 Tm (increased )Tj EMC /Suspect <>BDC -0.0088 Tc 9.4 0 0 9.4 48.38 424.57 Tm (after )Tj EMC ET BT 0.443 g /T1_1 1 Tf 0.0015 Tc 9.4 0 0 9.4 70.9306 424.57 Tm (chronic )Tj -0.0298 Tc 3.729 0 Td (exposure )Tj 0.282 g 0 Tc 4.347 0 Td (t)Tj 0.443 g 0.25 0 Td (o )Tj -0.0132 Tc 0.968 0 Td (cigareue )Tj -0.0162 Tc 4.139 0 Td (smoke )Tj 0 Tc 3.307 0 Td ([)Tj 0.282 g -0.035 Tc 8.733 0 0 9.4 232.04 424.57 Tm (14)Tj 0.443 g 0 Tc 9.4 0 0 9.4 241.69 424.57 Tm (, )Tj 0.282 g -0.035 Tc 8.733 0 0 9.4 248.84 424.57 Tm (18)Tj 0.443 g 0 Tc 9.4 0 0 9.4 258.49 424.57 Tm (, )Tj -0.0176 Tc 0.677 0 Td (33] )Tj 0.365 0.365 0.361 rg -0.0147 Tc -22.986 -1.123 Td (but )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0222 Tc 9.4 0 0 9.4 65.2448 414.0138 Tm (this )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 9.3009 0 0 9.4 82.47 414.01 Tm (damage )Tj 8.9061 0 0 9.4 117.91 414.01 Tm (is )Tj 0.0152 Tc 9.4 0 0 9.4 127.59 414.01 Tm (quickly )Tj -0.026 Tc 3.565 0 Td (reversible )Tj -0.0029 Tc 4.494 0 Td (by )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0099 Tc 9.4 0 0 9.4 217.266 414.01 Tm (interrupting )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 9.1495 0 0 9.4 266.84 414.01 Tm (the )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0.0042 Tc 9.4 0 0 9.4 48.4 402.97 Tm (smoking )Tj EMC ET BT 0.282 g /T1_1 1 Tf 0.0046 Tc 9.4 0 0 9.4 87.1844 402.97 Tm (habit )Tj 0.443 g /T1_0 1 Tf -0.035 Tc 9.7752 0 0 10.3 111.6 402.97 Tm ([34 )Tj 0.282 g 0 Tc 10.3 0 0 10.3 125.7 402.97 Tm (\))Tj 0.443 g 0.265 0 Td (. )Tj 0.282 g /T1_1 1 Tf 9.4 0 0 9.4 135.14 402.97 Tm (H)Tj 0.443 g -0.0181 Tc 0.729 0 Td (owever, )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf 0.0188 Tc 7.6 0 0 7.6 178.3 402.97 Tm (10 )Tj EMC ET BT 0.443 g /T1_1 1 Tf -0.0257 Tc 9.4 0 0 9.4 189.5 402.97 Tm (exc)Tj 0.282 g -0.0086 Tc 1.523 0 Td (lud)Tj 0.443 g 0 Tc 1.336 0 Td (e )Tj 0.365 0.365 0.361 rg -0.0269 Tc 0.926 0 Td (the )Tj 0.2 g 0.0302 Tc 1.721 0 Td (innu)Tj 0.365 0.365 0.361 rg -0.035 Tc 8.9445 0 0 9.4 260.07 402.97 Tm (ence )Tj 0.443 g 0.05 Tc 10.5806 0 0 9.4 48.38 391.93 Tm (of )Tj -0.015 Tc 9.4 0 0 9.4 63.76 391.93 Tm (smo)Tj 0.282 g 0 Tc 1.828 0 Td (k)Tj 0.443 g 0.519 0 Td (e )Tj 0.365 0.365 0.361 rg -0.0186 Tc 1.227 0 Td (on )Tj -0.0241 Tc 1.928 0 Td (PAEP, )Tj -0.035 Tc 9.2908 0 0 9.4 149.76 391.93 Tm (we )Tj 0.443 g 0 Tc 9.4 0 0 9.4 168.37 391.93 Tm (c)Tj 0.282 g 0.503 0 Td (h)Tj 0.443 g -0.035 Tc 8.521 0 0 9.4 178.48 391.93 Tm (ose )Tj 0.282 g 0 Tc 9.4 0 0 9.4 199.02 391.93 Tm (n)Tj 0.443 g 0.52 0 Td (o)Tj 0.282 g 0.501 0 Td (n)Tj 0.443 g 0.572 0 Td (s)Tj 0.282 g 0.398 0 Td (m)Tj 0.443 g 0.0078 Tc 0.827 0 Td (oking )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0066 Tc 9.4 0 0 9.4 255.2226 391.93 Tm (CrPO )Tj EMC ET BT /T1_1 1 Tf -0.015 Tc 9.4 0 0 9.4 48.3004 380.4056 Tm (patients. )Tj 0.0127 Tc 4.302 0 Td (They )Tj -0.0347 Tc 2.898 0 Td (presented )Tj 0.2 g 0 Tc 4.815 0 Td (t)Tj 0.443 g 0.25 0 Td (o )Tj 0.6 0.6 0.596 rg 0.391 0 Td (. )Tj ET BT /Suspect <>BDC 0.443 g /T1_0 1 Tf -0.035 Tc 5.9851 0 0 10.3 168.36 380.41 Tm (.s )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0251 Tc 9.4 0 0 9.4 177.57 380.41 Tm (values )Tj 0.282 g 0 Tc 3.354 0 Td (b)Tj 0.443 g 0.57 0 Td (e)Tj 0.282 g 0.0297 Tc 0.517 0 Td (tw)Tj 0.443 g -0.035 Tc 8.6589 0 0 9.4 228.87 380.41 Tm (ee)Tj 0.282 g 0 Tc 9.4 0 0 9.4 238.38 380.41 Tm (n )Tj -0.0005 Tc 1.123 0 Td (normal )Tj 0 Tc -21.345 -1.123 Td (n)Tj 0.443 g 0.571 0 Td (o)Tj 0.282 g 0.552 0 Td (n)Tj 0.443 g -0.035 Tc 9.3422 0 0 9.4 63.28 369.85 Tm (smo)Tj 0.282 g 0 Tc 9.4 0 0 9.4 80.46 369.85 Tm (k)Tj 0.443 g 0.519 0 Td (e)Tj 0.282 g 0.451 0 Td (r)Tj 0.443 g 0.368 0 Td (s )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.1455 0 0 9.4 101.19 369.85 Tm (and )Tj 0.443 g 0 Tc 9.4 0 0 9.4 120.4 369.85 Tm (s)Tj 0.282 g 0.449 0 Td (m)Tj 0.443 g 0.827 0 Td (o)Tj 0.282 g 0.552 0 Td (k)Tj 0.443 g -0.035 Tc 9.0551 0 0 9.4 142.47 369.85 Tm (ers, )Tj 0.365 0.365 0.361 rg 9.1853 0 0 9.4 161.1 369.85 Tm (bu)Tj 0.2 g 0 Tc 9.4 0 0 9.4 171.8 369.85 Tm (t )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.3252 0 0 9.4 179.04 369.85 Tm (were )Tj 0.443 g 0 Tc 9.4 0 0 9.4 202.45 369.85 Tm (c)Tj 0.2 g 0.503 0 Td (l)Tj 0.365 0.365 0.361 rg -0.035 Tc 8.521 0 0 9.4 209.68 369.85 Tm (ose)Tj 0.2 g 0 Tc 9.4 0 0 9.4 223.5 369.85 Tm (r )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf 0.0188 Tc 7.6 0 0 7.6 231.1 369.85 Tm (10 )Tj EMC ET BT 0.282 g /T1_1 1 Tf -0.035 Tc 9.1076 0 0 9.4 243.32 369.85 Tm (th)Tj 0.443 g 0 Tc 9.4 0 0 9.4 250.94 369.85 Tm (e )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf -0.0237 Tc 9.4 0 0 9.4 259.9828 369.85 Tm (non\255)Tj EMC ET BT 0.443 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 48.3982 358.7956 Tm (s)Tj 0.282 g 0.449 0 Td (m)Tj 0.443 g 0.827 0 Td (o)Tj 0.282 g 0.0054 Tc 0.501 0 Td (ker)Tj 0.443 g 0 Tc 1.389 0 Td (s )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.2743 0 0 9.4 88.77 358.8 Tm (values. )Tj 0.282 g 0 Tc 9.4 0 0 9.4 123.85 358.8 Tm (A )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 9.4 0 0 9.4 136.7186 358.8 Tm (s)Tj 0.282 g -0.016 Tc 0.464 0 Td (tati)Tj 0.443 g 0 Tc 1.323 0 Td (s)Tj 0.282 g 0.0188 Tc 0.464 0 Td (tically )Tj EMC ET BT 0.443 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 189.039 358.8 Tm (s)Tj 0.282 g 0.0362 Tc 0.449 0 Td (ignifi)Tj 0.443 g -0.035 Tc 8.7999 0 0 9.4 214.46 358.8 Tm (can)Tj 0.282 g 0 Tc 9.4 0 0 9.4 228.92 358.8 Tm (t )Tj 0.0026 Tc 0.914 0 Td (differen)Tj 0.443 g -0.035 Tc 9.0629 0 0 9.4 269.18 358.8 Tm (ce )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf 9.3635 0 0 9.4 48.3 348.25 Tm (between )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg 9.0962 0 0 9.4 86.75 348.25 Tm (CJPO )Tj EMC /Suspect <>BDC 0.282 g -0.0157 Tc 9.4 0 0 9.4 115.02 348.25 Tm (pati)Tj 0.443 g 0 Tc 1.591 0 Td (e)Tj 0.282 g -0.0335 Tc 0.502 0 Td (nts )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 9.1455 0 0 9.4 151.11 348.25 Tm (and )Tj 0.365 0.365 0.361 rg 9.2014 0 0 9.4 171.28 348.25 Tm (smokers )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0224 Tc 9.4 0 0 9.4 209.59 348.25 Tm (\(p>BDC 0.282 g /T1_1 1 Tf -0.0141 Tc 9.4 0 0 9.4 90.1994 337.2 Tm (time)Tj 0.443 g 0 Tc 1.885 0 Td (s )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 9.3252 0 0 9.4 116.16 337.2 Tm (were )Tj 0.2 g 8.9374 0 0 9.4 139.18 337.2 Tm (fa)Tj 0.443 g 0 Tc 9.4 0 0 9.4 146.8 337.2 Tm (s)Tj 0.2 g 0.464 0 Td (t)Tj 0.365 0.365 0.361 rg 0.249 0 Td (e)Tj 0.2 g 0.502 0 Td (r)Tj 0.443 g 0.317 0 Td (-)Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 7.8893 0 0 9.4 168.48 337.2 Tm (wac; )Tj EMC ET BT /T1_1 1 Tf 9.2738 0 0 9.4 187.59 337.2 Tm (observed. )Tj -0.0133 Tc 9.4 0 0 9.4 57.61 326.65 Tm (Among )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0105 Tc 9.4 0 0 9.4 91.2056 326.65 Tm (ARDS )Tj EMC /Suspect <>BDC 0.282 g 0 Tc 3.248 0 Td (p)Tj 0.443 g 0.57 0 Td (a)Tj 0.282 g -0.032 Tc 0.517 0 Td (ti)Tj 0.443 g -0.035 Tc 9.1098 0 0 9.4 137.18 326.65 Tm (ents, )Tj EMC /Suspect <>BDC 0.282 g -0.0157 Tc 9.4 0 0 9.4 159.66 326.65 Tm (pati)Tj 0.443 g 0 Tc 1.591 0 Td (e)Tj 0.282 g -0.0265 Tc 0.502 0 Td (nt )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 9.0109 0 0 9.4 190.87 326.65 Tm (no. )Tj 0.282 g 0 Tc 9.4 0 0 9.4 208.02 326.65 Tm (1 )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.1455 0 0 9.4 215.91 326.65 Tm (and )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf -0.0181 Tc 9.4 0 0 9.4 234.54 326.65 Tm (patient )Tj EMC ET BT 0.2 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 265.2592 326.65 Tm (n)Tj 0.365 0.365 0.361 rg -0.035 Tc 9.267 0 0 9.4 270.15 326.65 Tm (o. )Tj 0 Tc 9.4 0 0 9.4 47.9 315.6 Tm (6 )Tj 0.282 g -0.035 Tc 8.9377 0 0 9.4 59.35 315.6 Tm (had )Tj 0.443 g 0 Tc 9.4 0 0 9.4 79.6 315.6 Tm (s)Tj 0.282 g 0.464 0 Td (t)Tj 0.443 g -0.035 Tc 9.3473 0 0 9.4 86.31 315.6 Tm (opped )Tj 9.3422 0 0 9.4 117.04 315.6 Tm (smo)Tj 0.282 g 0.0354 Tc 9.4 0 0 9.4 133.74 315.6 Tm (kin)Tj 0.443 g 0 Tc 1.388 0 Td (g )Tj 0.2 g 1.18 0 Td (t)Tj 0.365 0.365 0.361 rg 0.0016 Tc 0.311 0 Td (wo )Tj -0.035 Tc 9.0972 0 0 9.4 179.52 315.6 Tm (weeks )Tj -0.0192 Tc 9.4 0 0 9.4 210.06 315.6 Tm (before )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf -0.035 Tc 9.0957 0 0 9.4 241.75 315.6 Tm (measure)Tj 0.443 g 0 Tc 9.4 0 0 9.4 274.96 315.6 Tm (\255)Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 9.3061 0 0 9.4 48.3 304.57 Tm (ments; )Tj 0.282 g 0.0282 Tc 9.4 0 0 9.4 79.02 304.57 Tm (in )Tj 0.365 0.365 0.361 rg -0.0283 Tc 1.234 0 Td (any )Tj 0.443 g -0.035 Tc 8.6734 0 0 9.4 109.34 304.57 Tm (case )Tj 0.365 0.365 0.361 rg 0.001 Tc 9.4 0 0 9.4 131 304.57 Tm (their )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 8.632 0 0 9.4 153.44 304.57 Tm (los )Tj EMC ET BT /T1_1 1 Tf 9.2168 0 0 9.4 167.97 304.57 Tm (values )Tj 9.3252 0 0 9.4 197.28 304.57 Tm (were )Tj -0.0181 Tc 9.4 0 0 9.4 220.21 304.57 Tm (close )Tj 0.2 g 0 Tc 2.663 0 Td (t)Tj 0.365 0.365 0.361 rg 0.25 0 Td (o )Tj -0.035 Tc 8.9835 0 0 9.4 257.24 304.57 Tm (those )Tj 0.443 g 0 Tc 9.4 0 0 9.4 47.91 293.53 Tm (o)Tj 0.282 g 0.569 0 Td (f )Tj 0.365 0.365 0.361 rg -0.0153 Tc 0.81 0 Td (other )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0105 Tc 9.4 0 0 9.4 85.933 293.53 Tm (ARDS )Tj EMC ET BT /T1_1 1 Tf -0.0213 Tc 9.4 0 0 9.4 117.423 293.53 Tm (patients, )Tj 0.443 g -0.035 Tc 8.6375 0 0 9.4 155.93 293.53 Tm (so )Tj 0.365 0.365 0.361 rg -0.0252 Tc 9.4 0 0 9.4 169.4 293.53 Tm (that )Tj 0.282 g -0.035 Tc 9.1076 0 0 9.4 188.6 293.53 Tm (th)Tj 0.443 g 0 Tc 9.4 0 0 9.4 196.22 293.53 Tm (e)Tj 0.282 g 0.05 Tc 11.0492 0 0 9.4 200.9 293.53 Tm (ir )Tj 0.443 g -0.0043 Tc 9.4 0 0 9.4 211.12 293.53 Tm (smoking )Tj 0.365 0.365 0.361 rg 0.0097 Tc 4.126 0 Td (history )Tj -0.0179 Tc -21.447 -1.176 Td (is )Tj 0.282 g 0.05 Tc 9.5642 0 0 9.4 58.86 282.48 Tm (lik)Tj 0.443 g 0.0112 Tc 9.4 0 0 9.4 69.02 282.48 Tm (ely )Tj 0.282 g 0 Tc 1.743 0 Td (t)Tj 0.443 g 0.301 0 Td (o )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.2561 0 0 9.4 97.26 282.48 Tm (have )Tj 9.2624 0 0 9.4 120.3 282.48 Tm (no )Tj -0.005 Tc 9.4 0 0 9.4 134.22 282.48 Tm (innuence )Tj -0.0186 Tc 4.35 0 Td (on )Tj -0.035 Tc 9.1104 0 0 9.4 189.42 282.48 Tm (measured )Tj -0.0241 Tc 9.4 0 0 9.4 231.63 282.48 Tm (PAEP. )Tj -0.0119 Tc 3.284 0 Td (The )Tj 0.282 g 0.0487 Tc -22.838 -1.122 Td (mild )Tj 0.443 g 0 Tc 2.664 0 Td (e)Tj 0.282 g -0.035 Tc 9.0067 0 0 9.4 77.59 271.93 Tm (nhan)Tj 0.443 g 9.1066 0 0 9.4 96.86 271.93 Tm (cemen)Tj 0.282 g 0 Tc 9.4 0 0 9.4 123.8 271.93 Tm (t )Tj 0.443 g 0.05 Tc 10.5806 0 0 9.4 132.38 271.93 Tm (of )Tj 0.365 0.365 0.361 rg -0.0079 Tc 9.4 0 0 9.4 147.63 271.93 Tm (PAEP )Tj -0.0229 Tc 3.373 0 Td (in )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.012 Tc 9.4 0 0 9.4 192.8158 271.93 Tm (CIPO )Tj EMC ET BT /T1_1 1 Tf -0.0286 Tc 9.4 0 0 9.4 222.5386 271.93 Tm (patients )Tj 0.0044 Tc 4.053 0 Td (with )Tj 0.443 g -0.035 Tc 9.1199 0 0 9.4 47.83 260.88 Tm (respect )Tj 0.282 g 9.1076 0 0 9.4 79.64 260.88 Tm (to )Tj 0.365 0.365 0.361 rg -0.021 Tc 9.4 0 0 9.4 90.54 260.88 Tm (normal )Tj 0.443 g -0.035 Tc 9.3141 0 0 9.4 121.84 260.88 Tm (subjects )Tj 0.365 0.365 0.361 rg 8.9061 0 0 9.4 157.75 260.88 Tm (is )Tj 0.002 Tc 9.4 0 0 9.4 167.82 260.88 Tm (limited )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.0574 0 0 8.3 198.92 260.88 Tm (10 )Tj EMC /Suspect <>BDC /T1_1 1 Tf 9.1495 0 0 9.6 210.2 260.88 Tm (the )Tj EMC ET BT /T1_1 1 Tf -0.0057 Tc 9.4 0 0 9.4 225.9 260.88 Tm (middle-lower )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0061 Tc 9.4 0 0 9.4 47.7794 249.8444 Tm (ROI )Tj EMC /Suspect <>BDC 0.443 g -0.0241 Tc 2.212 0 Td ({tab)Tj 0.282 g 0 Tc 1.673 0 Td (l)Tj 0.443 g 0.264 0 Td (e )Tj EMC ET BT /T1_1 1 Tf -0.0082 Tc 9.4 0 0 9.4 94.9298 249.8444 Tm (3\). )Tj 0.365 0.365 0.361 rg 0.0389 Tc 1.567 0 Td (In )Tj -0.0115 Tc 1.353 0 Td (fact )Tj -0.0269 Tc 1.938 0 Td (the )Tj -0.0163 Tc 1.67 0 Td (upper )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.016 Tc 9.4 0 0 9.4 183.13 249.8444 Tm (ROt's )Tj EMC ET BT /T1_1 1 Tf -0.0249 Tc 9.4 0 0 9.4 210.9822 249.8444 Tm (PAEP )Tj 0.443 g 0.0068 Tc 2.966 0 Td (\(normally )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf 0.0038 Tc 9.4 0 0 9.4 47.817 238.8088 Tm (higher )Tj EMC /Suspect <>BDC -0.035 Tc 9.1676 0 0 9.4 79.16 238.8 Tm (than )Tj EMC ET BT /T1_1 1 Tf -0.0269 Tc 9.4 0 0 9.4 101.72 238.8 Tm (the )Tj -0.0079 Tc 1.871 0 Td (PAEP )Tj 0.443 g 0.05 Tc 10.5806 0 0 9.4 149.18 238.8 Tm (of )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.1495 0 0 9.4 163.16 238.8 Tm (the )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0245 Tc 9.4 0 0 9.4 180.78 238.8 Tm (remruning )Tj EMC ET BT /T1_1 1 Tf 0.0032 Tc 9.4 0 0 9.4 226.86 238.8 Tm (lung\) )Tj -0.0179 Tc 2.809 0 Td (is )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf -0.0104 Tc 9.4 0 0 9.4 265.2684 238.8 Tm (not )Tj EMC ET BT /T1_1 1 Tf -0.0038 Tc 9.4 0 0 9.4 47.9874 228.2532 Tm (furth)Tj 0.443 g 0.0028 Tc 2.034 0 Td (er )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 9.3257 0 0 9.4 81.42 228.25 Tm (increased )Tj EMC ET BT 0.443 g /T1_1 1 Tf 0.0282 Tc 9.4 0 0 9.4 125.58 228.25 Tm (in )Tj /T1_0 1 Tf -0.0204 Tc 10.5 0 0 10.5 139.09 228.25 Tm (CIPO )Tj 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0277 Tc 9.4 0 0 9.4 168.3 228.25 Tm (patients. )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 9.2236 0 0 9.4 208.29 228.25 Tm (We )Tj EMC ET BT /T1_1 1 Tf -0.0035 Tc 9.4 0 0 9.4 227.82 228.25 Tm (believe )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0252 Tc 9.4 0 0 9.4 263.0042 228.25 Tm (that )Tj EMC ET BT 0.443 g /T1_1 1 Tf 0.0164 Tc 9.4 0 0 9.4 47.434 216.7256 Tm (gravity )Tj 0.365 0.365 0.361 rg -0.0315 Tc 3.616 0 Td (may )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.0264 Tc 9.4 0 0 9.4 103.5802 216.7256 Tm (account )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 0.026 Tc 9.4 0 0 9.4 140.6162 216.7256 Tm (for )Tj -0.035 Tc 9.1495 0 0 9.4 157.4 216.73 Tm (the )Tj -0.0313 Tc 9.4 0 0 9.4 174.15 216.73 Tm (dependent )Tj 0.282 g -0.0086 Tc 4.995 0 Td (lun)Tj 0.443 g 0 Tc 1.337 0 Td (g )Tj 0.365 0.365 0.361 rg -0.035 Tc 8.8298 0 0 9.4 243.75 216.73 Tm (areas )Tj 0.443 g 0.05 Tc 10.5806 0 0 9.4 269.18 216.73 Tm (of )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 9.2061 0 0 9.4 47.82 206.17 Tm (increased )Tj EMC /Suspect <>BDC 0.0004 Tc 9.4 0 0 9.4 89.58 206.17 Tm (permeability )Tj EMC ET BT /T1_1 1 Tf 0.0282 Tc 9.4 0 0 9.4 144.2974 206.17 Tm (in )Tj 0.443 g 0.012 Tc 1.179 0 Td (CIPO )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0341 Tc 9.4 0 0 9.4 182.6964 206.17 Tm (patients. )Tj EMC /Suspect <>BDC 0.05 Tc 9.4793 0 0 9.4 56.1 195.13 Tm (Two )Tj EMC ET BT 0.443 g /T1_1 1 Tf -0.0286 Tc 9.4 0 0 9.4 81.03 195.13 Tm (othe)Tj 0.282 g 0 Tc 1.88 0 Td (r )Tj 0.443 g -0.0335 Tc 1.082 0 Td (groups )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0023 Tc 9.4 0 0 9.4 142.8538 195.13 Tm ([24, )Tj EMC ET BT /T1_1 1 Tf -0.0208 Tc 9.4 0 0 9.4 164.5678 195.13 Tm (25\) )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.2561 0 0 9.4 185.1 195.13 Tm (have )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 210.06 195.13 Tm (r)Tj 0.443 g 0.0123 Tc 0.314 0 Td (ccenlly )Tj EMC ET BT /T1_1 1 Tf -0.0231 Tc 9.4 0 0 9.4 248.5624 195.13 Tm (studied )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0484 Tc 9.4 0 0 9.4 47.4024 184.0944 Tm (""'Tc-DTPA )Tj EMC /Suspect <>BDC 0 Tc 5.873 0 Td (c)Tj 0.282 g 0.503 0 Td (l)Tj 0.443 g -0.035 Tc 8.9488 0 0 9.4 110.31 184.09 Tm (earance )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 0.0282 Tc 9.4 0 0 9.4 145.26 184.09 Tm (in )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0065 Tc 9.4 0 0 9.4 157.4518 184.09 Tm (ARDS)Tj 0.537 g 0 Tc 2.883 0 Td (. )Tj EMC ET BT 0.443 g /T1_1 1 Tf -0.0004 Tc 9.4 0 0 9.4 191.5362 184.09 Tm (Accordjng )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf 0.0188 Tc 7.6 0 0 7.6 237.82 184.09 Tm (10 )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 9.0039 0 0 9.4 249.4 184.09 Tm (MAsoN )Tj 0.443 g /T1_2 1 Tf 0.0135 Tc 10 0 0 10 47.43 173.05 Tm (et )Tj 0.365 0.365 0.361 rg -0.0051 Tc 1.25 0 Td (al. )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0.0044 Tc 9.4 0 0 9.4 76.13 173.05 Tm ([24}, )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg -0.035 Tc 9.1495 0 0 9.4 100.76 173.05 Tm (the )Tj EMC /Suspect <>BDC 0.443 g 0.0175 Tc 9.4 0 0 9.4 118 173.05 Tm (striking )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg -0.035 Tc 9.2051 0 0 9.4 154.86 173.05 Tm (increase )Tj EMC ET BT /T1_1 1 Tf -0.0229 Tc 9.4 0 0 9.4 193.26 173.05 Tm (in )Tj -0.0249 Tc 1.376 0 Td (PAEP )Tj 0.05 Tc 9.7493 0 0 9.4 235.49 173.05 Tm (in )Tj /T1_0 1 Tf 0.007 Tc 9.6 0 0 9.6 249.02 173.05 Tm (all )Tj 0.443 g /T1_1 1 Tf 0.0029 Tc 9.4 0 0 9.4 264.39 173.05 Tm (our )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0065 Tc 9.4 0 0 9.4 47.532 162.4844 Tm (ARDS )Tj EMC /Suspect <>BDC -0.0213 Tc 3.248 0 Td (patients )Tj EMC ET BT /T1_1 1 Tf -0.0221 Tc 9.4 0 0 9.4 114.0652 162.4844 Tm (indicates )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 9.1495 0 0 9.4 153.56 162.48 Tm (the )Tj EMC ET BT /T1_1 1 Tf -0.0037 Tc 9.4 0 0 9.4 169.74 162.48 Tm (high )Tj -0.0086 Tc 2.307 0 Td (diagnostic )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0.0029 Tc 9.4 0 0 9.4 236.5552 162.48 Tm (sensitivity )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 0.05 Tc 11.1375 0 0 9.4 46.93 150.97 Tm (of )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf -0.0131 Tc 9.4 0 0 9.4 60.92 150.97 Tm (thi)Tj 0.443 g 0 Tc 1.068 0 Td (s )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0285 Tc 9.4 0 0 9.4 79.5038 150.97 Tm (parameter. )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.049 Tc 9.4 0 0 9.4 127.0772 150.97 Tm (Our )Tj EMC ET BT 0.282 g /T1_1 1 Tf 0.0051 Tc 9.4 0 0 9.4 148.3118 150.97 Tm (find)Tj 0.443 g -0.0192 Tc 1.719 0 Td (ings )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0189 Tc 9.4 0 0 9.4 185.188 150.97 Tm (arc )Tj EMC ET BT /T1_1 1 Tf -0.0248 Tc 9.4 0 0 9.4 202.4652 150.97 Tm (also )Tj /T1_0 1 Tf -0.035 Tc 9.2582 0 0 10.1 224.08 150.97 Tm (in )Tj 0.443 g /T1_1 1 Tf 9.3307 0 0 9.4 236.06 150.97 Tm (agreement )Tj 0.365 0.365 0.361 rg 0.0215 Tc 9.4 0 0 9.4 47.52 140.41 Tm (with )Tj -0.035 Tc 9.1924 0 0 9.4 70.04 140.41 Tm (those )Tj 0.282 g 0 Tc 9.4 0 0 9.4 95.82 140.41 Tm (r)Tj 0.443 g -0.0306 Tc 0.315 0 Td (epo)Tj 0.282 g -0.035 Tc 8.9905 0 0 9.4 114.07 140.41 Tm (rted )Tj 0.365 0.365 0.361 rg 9.22 0 0 9.4 134.22 140.41 Tm (by )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 7.7313 0 0 8 149.25 140.41 Tm (BRAUDE )Tj EMC ET BT 0.443 g /T1_2 1 Tf 0.0135 Tc 10 0 0 10 184.23 140.41 Tm (et )Tj 0.365 0.365 0.361 rg -0.0291 Tc 1.202 0 Td (al. )Tj 0.443 g /T1_0 1 Tf 0.013 Tc 9.2 0 0 9.2 211.46 140.41 Tm ([25] )Tj 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 9.2678 0 0 9.4 232.8 140.41 Tm (who )Tj 0.282 g -0.0272 Tc 9.4 0 0 9.4 254.38 140.41 Tm (found )Tj 0.365 0.365 0.361 rg -0.0252 Tc -22.011 -1.124 Td (that )Tj 0.282 g 0 Tc 9.8 0 0 9.8 69.39 129.84 Tm (K )Tj 0.365 0.365 0.361 rg -0.035 Tc 8.5199 0 0 9.4 84.93 129.84 Tm (va)Tj 0.2 g 0 Tc 9.4 0 0 9.4 94.38 129.84 Tm (l)Tj 0.365 0.365 0.361 rg -0.035 Tc 8.9532 0 0 9.4 96.79 129.84 Tm (ues )Tj 9.3252 0 0 9.4 118.08 129.84 Tm (were )Tj 0.443 g 0.0019 Tc 9.4 0 0 9.4 144.88 129.84 Tm (significant)Tj 0.282 g 0.0331 Tc 4.585 0 Td (ly )Tj 0.0285 Tc 1.583 0 Td (hi)Tj 0.443 g 0 Tc 0.776 0 Td (g)Tj 0.282 g 0.552 0 Td (h)Tj 0.443 g 0.519 0 Td (e)Tj 0.2 g 0.502 0 Td (r )Tj 0.365 0.365 0.361 rg -0.0229 Tc 1.174 0 Td (in )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0065 Tc 9.4 0 0 9.4 251.0436 129.84 Tm (ARDS )Tj EMC /Suspect <>BDC -0.024 Tc -21.671 -1.174 Td (paticms )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 9.2553 0 0 9.4 85.92 118.8 Tm (when )Tj 9.2875 0 0 9.4 114.62 118.8 Tm (compared )Tj 0.282 g 9.1076 0 0 9.4 161.72 118.8 Tm (to )Tj 0.365 0.365 0.361 rg 8.7736 0 0 9.4 176.47 118.8 Tm (normaJ )Tj -0.0107 Tc 9.4 0 0 9.4 211.57 118.8 Tm (controls. )Tj 0.282 g -0.0294 Tc 4.448 0 Td (Th)Tj 0.443 g -0.035 Tc 8.5362 0 0 9.4 264.39 118.8 Tm (ese )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf -0.0022 Tc 9.4 0 0 9.4 46.86 107.76 Tm (inve)Tj 0.443 g 0 Tc 1.849 0 Td (s)Tj 0.2 g 0.0191 Tc 0.464 0 Td (ti)Tj 0.365 0.365 0.361 rg -0.0288 Tc 0.556 0 Td (gators )Tj EMC ET BT 0.282 g /T1_1 1 Tf 0.0144 Tc 9.4 0 0 9.4 105.1024 107.76 Tm (fail)Tj 0.443 g -0.035 Tc 8.6589 0 0 9.4 117.99 107.76 Tm (ed )Tj 0.282 g 9.1076 0 0 9.4 134.36 107.76 Tm (to )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0274 Tc 9.4 0 0 9.4 147.75 107.76 Tm (detect )Tj EMC ET BT /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 177.9804 107.76 Tm (a )Tj 0.443 g 0.0352 Tc 1.074 0 Td (sig)Tj 0.282 g 0.0131 Tc 1.317 0 Td (nificant )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf 0.0191 Tc 9.4 0 0 9.4 236.5424 107.76 Tm (differe)Tj 0.2 g 0 Tc 2.901 0 Td (n)Tj 0.443 g -0.035 Tc 9.0629 0 0 9.4 268.22 107.76 Tm (ce )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg 9.3635 0 0 9.4 46.86 96.72 Tm (between )Tj EMC /Suspect <>BDC 0.282 g 5.4897 0 0 9.4 85.9 96.72 Tm (t11)Tj 0.443 g 0 Tc 9.4 0 0 9.4 93.49 96.72 Tm (c )Tj EMC ET BT 0.282 g /T1_1 1 Tf 9.4 0 0 9.4 103.9616 96.72 Tm (K )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.2168 0 0 9.4 116.13 96.72 Tm (values )Tj 0.443 g 0 Tc 9.4 0 0 9.4 145.83 96.72 Tm (o)Tj 0.282 g 0.62 0 Td (f )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0065 Tc 9.4 0 0 9.4 159.8454 96.72 Tm (ARDS )Tj EMC /Suspect <>BDC -0.0286 Tc 3.401 0 Td (patients )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.7229 0 0 9.2 227.89 96.72 Tm (\(K )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0086 Tc 9.4 0 0 9.4 243.68 96.72 Tm (%\267min)Tj 0.537 g 0 Tc 2.748 0 Td (\267)Tj 0.365 0.365 0.361 rg /T1_0 1 Tf 6.2 0 0 6.2 271.95 100.56 Tm (1)Tj 0.484 -0.619 Td (, )Tj EMC ET BT 0.282 g /T1_1 1 Tf -0.0021 Tc 9.4 0 0 9.4 46.86 85.68 Tm (mcan)Tj 0.443 g -0.0067 Tc 2.46 0 Td (\261so: )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0206 Tc 9.4 0 0 9.4 95.411 85.68 Tm (5.2\2610.9\) )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 9.1455 0 0 9.4 138.63 85.68 Tm (and )Tj 0.282 g 9.1076 0 0 9.4 160.76 85.68 Tm (th)Tj 0.443 g -0.0295 Tc 9.4 0 0 9.4 168.87 85.68 Tm (ose )Tj 0 Tc 2.196 0 Td (o)Tj 0.2 g 0.62 0 Td (f )Tj 0.282 g 0.0199 Tc 1.055 0 Td (normal )Tj 0.365 0.365 0.361 rg -0.015 Tc 3.891 0 Td (smo)Tj 0.2 g 0 Tc 1.879 0 Td (k)Tj 0.365 0.365 0.361 rg 0.57 0 Td (e)Tj 0.2 g 0.502 0 Td (r)Tj 0.443 g 0.419 0 Td (s )Tj 0.05 Tc 9.4127 0 0 9.4 299.83 736.57 Tm (\(K )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0229 Tc 9.4 0 0 9.4 313.81 736.57 Tm (3.6\2610.8\) )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 9.3229 0 0 9.4 350.7 736.57 Tm (but )Tj 0.365 0.365 0.361 rg 0.0282 Tc 9.4 0 0 9.4 367.02 736.57 Tm (in )Tj 0.443 g 0.0284 Tc 1.133 0 Td (our )Tj -0.0062 Tc 1.838 0 Td (opinion )Tj 0.365 0.365 0.361 rg 0.001 Tc 3.631 0 Td (their )Tj 0.443 g -0.0305 Tc 2.243 0 Td (smokers )Tj 0.365 0.365 0.361 rg -0.019 Tc 3.982 0 Td (group )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.035 Tc 9.0091 0 0 10.3 514.56 736.57 Tm (was )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0269 Tc 9.4 0 0 9.4 299.96 725.52 Tm (too )Tj 0.443 g -0.0164 Tc 1.936 0 Td (small )Tj -0.035 Tc 9.3103 0 0 9.4 345.44 725.52 Tm (\(7 )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0315 Tc 9.4 0 0 9.4 359.44 725.52 Tm (subjects\) )Tj EMC /Suspect <>BDC 0.282 g 0 Tc 4.447 0 Td (t)Tj 0.443 g 0.25 0 Td (o )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg -0.035 Tc 9.2287 0 0 9.4 414.14 725.52 Tm (aJiow )Tj EMC ET BT /T1_1 1 Tf 0.0111 Tc 9.4 0 0 9.4 442.47 725.52 Tm (definite )Tj 0.443 g -0.0182 Tc 3.879 0 Td (conc)Tj 0.282 g 0.0282 Tc 2.086 0 Td (lu)Tj 0.443 g -0.035 Tc 9.3405 0 0 9.4 505.84 725.52 Tm (sions. )Tj 0.365 0.365 0.361 rg 9.3725 0 0 9.4 299.46 714.96 Tm (The )Tj 0.443 g 9.137 0 0 9.4 322 714.96 Tm (smoke)Tj 0.282 g 0 Tc 9.4 0 0 9.4 347.82 714.96 Tm (r)Tj 0.443 g 0.0011 Tc 0.415 0 Td ('s )Tj 0.365 0.365 0.361 rg -0.0038 Tc 1.423 0 Td (lung )Tj 0.443 g -0.0179 Tc 2.604 0 Td (is )Tj 0.365 0.365 0.361 rg -0.0147 Tc 1.43 0 Td (undoubtedly )Tj -0.0145 Tc 6.077 0 Td (more )Tj -0.0312 Tc 2.911 0 Td (permeable )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 8.9057 0 0 9.4 299.96 703.93 Tm (than )Tj EMC ET BT /T1_1 1 Tf 9.1495 0 0 9.4 320.6 703.93 Tm (the )Tj -0.0139 Tc 9.4 0 0 9.4 336.3 703.93 Tm (nonsmoker's, )Tj -0.0147 Tc 6.128 0 Td (but )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 9.1495 0 0 9.4 410.84 703.93 Tm (the )Tj EMC ET BT /T1_1 1 Tf 9.2494 0 0 9.4 426.63 703.93 Tm (degree )Tj 0.443 g 0 Tc 9.4 0 0 9.4 457.35 703.93 Tm (o)Tj 0.282 g 0.569 0 Td (f )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_3 1 Tf -0.0322 Tc 9.9 0 0 9.9 469.76 703.93 Tm (this )Tj EMC /Suspect <>BDC /T1_1 1 Tf -0.0171 Tc 9.4 0 0 9.4 488.06 703.93 Tm (abnormal\255)Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 9.5207 0 0 9.4 299.82 693.37 Tm (ity )Tj 0.443 g -0.035 Tc 8.9061 0 0 9.4 316.63 693.37 Tm (is )Tj -0.0083 Tc 9.4 0 0 9.4 334.93 693.37 Tm (controversial, )Tj 0.365 0.365 0.361 rg -0.0035 Tc 6.478 0 Td (probably )Tj 0.443 g -0.035 Tc 9.0895 0 0 9.4 437.59 693.37 Tm (because )Tj 0.365 0.365 0.361 rg 0.05 Tc 10.5806 0 0 9.4 475.58 693.37 Tm (of )Tj -0.035 Tc 9.1495 0 0 9.4 491 693.37 Tm (the )Tj -0.0223 Tc 9.4 0 0 9.4 509.1 693.37 Tm (large )Tj 0.008 Tc -22.264 -1.174 Td (intcrindividual )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0.013 Tc 9.4 0 0 9.4 363.3248 682.3344 Tm (variability )Tj EMC ET BT /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 408.7738 682.3344 Tm (i)Tj 0.282 g 0.255 0 Td (n )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0.0057 Tc 9.4 0 0 9.4 420.8716 682.3344 Tm (susceptibility )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 0.05 Tc 10.5806 0 0 9.4 479.42 682.33 Tm (of )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0241 Tc 9.4 0 0 9.4 492.4 682.33 Tm (smokers' )Tj EMC ET BT 0.282 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 299.8222 671.2756 Tm (l)Tj 0.443 g -0.035 Tc 9.0201 0 0 9.4 302.71 671.28 Tm (ungs )Tj 0.365 0.365 0.361 rg 5.6906 0 0 8.2 326.28 671.28 Tm (LO )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 9.1495 0 0 9.4 338.84 671.28 Tm (the )Tj EMC ET BT 0.443 g /T1_1 1 Tf -0.013 Tc 9.4 0 0 9.4 355.09 671.28 Tm (cigarette-)Tj 0.282 g -0.0208 Tc 4.078 0 Td (indu)Tj 0.443 g -0.035 Tc 8.7999 0 0 9.4 410.78 671.28 Tm (ced )Tj 0.365 0.365 0.361 rg 9.3418 0 0 9.4 429.51 671.28 Tm (damage. )Tj 9.3725 0 0 9.4 468.42 671.28 Tm (The )Tj 9.2494 0 0 9.4 489.03 671.28 Tm (degree )Tj 0.05 Tc 10.5806 0 0 9.4 520.22 671.28 Tm (of )Tj -0.0079 Tc 9.4 0 0 9.4 299.31 660.25 Tm (PAEP )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 8.9303 0 0 9.4 331.51 660.25 Tm (increase )Tj EMC ET BT /T1_1 1 Tf -0.0229 Tc 9.4 0 0 9.4 367.02 660.25 Tm (in )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf -0.035 Tc 9.1076 0 0 9.4 378.2 660.25 Tm (th)Tj 0.443 g 0 Tc 9.4 0 0 9.4 385.82 660.25 Tm (e )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 9.0753 0 0 9.4 393.52 660.25 Tm (smo)Tj 0.282 g 0 Tc 9.4 0 0 9.4 410.22 660.25 Tm (k)Tj 0.443 g -0.035 Tc 8.894 0 0 9.4 415.11 660.25 Tm (ers )Tj 0.365 0.365 0.361 rg -0.019 Tc 9.4 0 0 9.4 430.47 660.25 Tm (group )Tj 0.443 g 0 Tc 2.861 0 Td (s)Tj 0.282 g -0.0325 Tc 0.464 0 Td (tudied )Tj 0.365 0.365 0.361 rg -0.0029 Tc 2.998 0 Td (by )Tj /T1_0 1 Tf -0.035 Tc 10.1243 0 0 11.3 503.52 660.25 Tm (us )Tj 0.443 g /T1_1 1 Tf 9.2727 0 0 9.4 515.84 660.25 Tm (\(13 )Tj 9.3542 0 0 9.4 299.44 649.69 Tm (subjects, )Tj 8.5358 0 0 9.4 339.27 649.69 Tm (age )Tj 0.365 0.365 0.361 rg 9.1935 0 0 9.4 357.91 649.69 Tm (range )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 386.1 649.69 Tm (1)Tj 0.443 g 0.0394 Tc 0.429 0 Td (8-50 )Tj EMC ET BT /T1_1 1 Tf -0.0235 Tc 9.4 0 0 9.4 415.1648 649.69 Tm (yrs; )Tj 0.365 0.365 0.361 rg 0 Tc 2.128 0 Td (K )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0069 Tc 9.4 0 0 9.4 448.0272 649.69 Tm (1.9\2610.7\) )Tj EMC ET BT /T1_1 1 Tf -0.0023 Tc 9.4 0 0 9.4 487.0184 649.69 Tm ([33] )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0.031 Tc 9.4 0 0 9.4 507.736 649.69 Tm (co)Tj 0.282 g 0 Tc 1.065 0 Td (m)Tj 0.443 g 0.828 0 Td (\255)Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 9.4 0 0 9.4 299.3474 639.1338 Tm (p)Tj 0.2 g 0.562 0 Td (l)Tj 0.443 g -0.035 Tc 8.894 0 0 9.4 307.11 639.13 Tm (ete)Tj 0.2 g 0 Tc 9.4 0 0 9.4 319.02 639.13 Tm (l)Tj 0.443 g 0.321 0 Td (y )Tj -0.035 Tc 8.6565 0 0 9.4 329.67 639.13 Tm (ag)Tj 0.2 g 0 Tc 9.4 0 0 9.4 339.66 639.13 Tm (r)Tj 0.443 g -0.035 Tc 8.22 0 0 9.4 342.63 639.13 Tm (ees )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf 0.0044 Tc 9.4 0 0 9.4 359.04 639.13 Tm (with )Tj EMC ET BT 0.282 g /T1_1 1 Tf -0.0252 Tc 9.4 0 0 9.4 380.1242 639.13 Tm (that )Tj 0.2 g 0 Tc 1.926 0 Td (r)Tj 0.443 g -0.035 Tc 9.2769 0 0 9.4 401.66 639.13 Tm (eported )Tj 0.365 0.365 0.361 rg 9.22 0 0 9.4 435.18 639.13 Tm (by )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 7.726 0 0 9.4 448.64 639.13 Tm (KENNEDY )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_2 1 Tf 0.0135 Tc 10 0 0 10 488.07 639.13 Tm (et )Tj -0.0051 Tc 1.058 0 Td (al. )Tj /T1_0 1 Tf 0.0242 Tc 9.3 0 0 9.3 512.42 639.13 Tm ([18] )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 299.35 628.09 Tm (\()Tj 0.282 g -0.035 Tc 8.733 0 0 9.4 304.04 628.09 Tm (10 )Tj EMC ET BT 0.443 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 318.64 628.09 Tm (s)Tj 0.282 g -0.0083 Tc 0.449 0 Td (ubj)Tj 0.443 g -0.035 Tc 9.3719 0 0 9.4 335.42 628.09 Tm (ects, )Tj 0.365 0.365 0.361 rg 9.2527 0 0 9.4 359.82 628.09 Tm (mean\261so: )Tj 0.443 g -0.0183 Tc 9.4 0 0 9.4 405.01 628.09 Tm (32.4\2616.4 )Tj 0.365 0.365 0.361 rg -0.0065 Tc 4.45 0 Td (yrs; )Tj 0.282 g /T1_0 1 Tf 0 Tc 10.5 0 0 10.5 468.91 628.09 Tm (K )Tj 0.365 0.365 0.361 rg /T1_1 1 Tf -0.007 Tc 9.4 0 0 9.4 481.36 628.09 Tm (2.12\2610.84\). )Tj -0.0156 Tc -19.369 -1.176 Td (From )Tj 0.282 g -0.035 Tc 9.1076 0 0 9.4 327.32 617.04 Tm (th)Tj 0.443 g 8.22 0 0 9.4 334.95 617.04 Tm (ese )Tj 0.365 0.365 0.361 rg -0.0247 Tc 9.4 0 0 9.4 353.74 617.04 Tm (figures )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf 0.05 Tc 10.3785 0 0 9.4 387.16 617.04 Tm (it )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0179 Tc 9.4 0 0 9.4 398.7 617.04 Tm (is )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 410.7696 617.04 Tm (c)Tj 0.2 g 0.554 0 Td (l)Tj 0.365 0.365 0.361 rg -0.0213 Tc 0.213 0 Td (ear )Tj EMC /Suspect <>BDC 0.282 g -0.0252 Tc 2.049 0 Td (that )Tj EMC ET BT /T1_1 1 Tf -0.0079 Tc 9.4 0 0 9.4 458.1926 617.04 Tm (PAEP )Tj -0.0229 Tc 3.271 0 Td (in )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0065 Tc 9.4 0 0 9.4 502.0906 617.04 Tm (ARDS )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg -0.0232 Tc -21.569 -1.123 Td (patie)Tj 0.2 g 0 Tc 2.043 0 Td (n)Tj 0.365 0.365 0.361 rg -0.035 Tc 7.8416 0 0 9.4 323.96 606.48 Tm (ts )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 9.4127 0 0 8.5 333.91 606.48 Tm (\(K )Tj -0.035 Tc 9.224 0 0 9.4 347.49 606.48 Tm (4.5)Tj 0.537 g 0 Tc 9.4 0 0 9.4 359.9 606.48 Tm (\261 )Tj ET BT /Suspect <>BDC 0.2 g /T1_1 1 Tf 8.5 0 0 8.5 366.97 606.48 Tm (I)Tj 0.443 g 0.405 0 Td (\) )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.035 Tc 9.3682 0 0 10.2 378.16 606.48 Tm (is )Tj EMC ET BT 0.443 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 387.76 606.48 Tm (s)Tj 0.282 g 0.449 0 Td (i)Tj 0.443 g 0.265 0 Td (g)Tj 0.282 g 0.0212 Tc 0.552 0 Td (nificanlly )Tj -0.0064 Tc 4.443 0 Td (higher )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf 0 Tc 8.5 0 0 8.5 470.25 606.48 Tm (\()Tj 0.282 g -0.0331 Tc 0.394 0 Td (p>BDC 0.282 g 0.0044 Tc 9.4 0 0 9.4 508.8 606.48 Tm (with)Tj 0.443 g 0 Tc 1.779 0 Td (\255)Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 9.4 0 0 9.4 299.4338 595.9332 Tm (o)Tj 0.2 g 0.0249 Tc 0.552 0 Td (ut )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.1667 0 0 9.4 320.07 595.93 Tm (any )Tj -0.0295 Tc 9.4 0 0 9.4 342.15 595.93 Tm (ove)Tj 0.2 g -0.0291 Tc 1.573 0 Td (rl)Tj 0.365 0.365 0.361 rg -0.035 Tc 8.6565 0 0 9.4 362.79 595.93 Tm (ap )Tj 0.282 g -0.0229 Tc 9.4 0 0 9.4 380.46 595.93 Tm (in )Tj 0.365 0.365 0.361 rg -0.0251 Tc 1.599 0 Td (values )Tj -0.0302 Tc 3.568 0 Td (observed )Tj 0 Tc 4.739 0 Td (i)Tj 0.2 g 0.306 0 Td (n )Tj 0.365 0.365 0.361 rg -0.0035 Tc 1.337 0 Td (otherw)Tj 0.2 g 0 Tc 3.054 0 Td (i)Tj 0.443 g -0.035 Tc 8.6375 0 0 9.4 520.25 595.93 Tm (se )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 299.4 584.89 Tm (")Tj 0.2 g 0.504 0 Td (n)Tj 0.443 g 0.52 0 Td (o)Tj 0.282 g -0.0131 Tc 0.552 0 Td (rmal)Tj 0.443 g 0 Tc 1.998 0 Td (" )Tj EMC ET BT /T1_1 1 Tf 9.4 0 0 9.4 345.037 584.89 Tm (s)Tj 0.282 g 0.449 0 Td (m)Tj 0.443 g -0.004 Tc 0.776 0 Td (oke)Tj 0.282 g 0 Tc 1.624 0 Td (r)Tj 0.443 g -0.035 Tc 8.6511 0 0 9.4 374.81 584.89 Tm (s. )Tj ET BT /Suspect <>BDC 0.2 g /T1_1 1 Tf -0.0122 Tc 9.4 0 0 9.4 389.98 584.89 Tm (In )Tj EMC /Suspect <>BDC 0.282 g 0.0105 Tc 1.663 0 Td (ARDS )Tj EMC /Suspect <>BDC -0.014 Tc 3.707 0 Td (patients )Tj EMC ET BT /T1_1 1 Tf 0.0261 Tc 9.4 0 0 9.4 479.7876 584.89 Tm (PAEP )Tj 0.365 0.365 0.361 rg -0.035 Tc 8.7276 0 0 9.4 513.6 584.89 Tm (was )Tj 0.282 g -0.0229 Tc 9.4 0 0 9.4 299.82 574.33 Tm (in)Tj 0.443 g -0.035 Tc 8.7868 0 0 9.4 307.1 574.33 Tm (creased )Tj 0.365 0.365 0.361 rg -0.0056 Tc 9.4 0 0 9.4 342.13 574.33 Tm (5.6-fo)Tj 0.2 g 0 Tc 2.546 0 Td (l)Tj 0.365 0.365 0.361 rg 0.265 0 Td (d )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0044 Tc 9.4 0 0 9.4 379.2036 574.33 Tm (with )Tj EMC ET BT 0.2 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 401.1056 574.33 Tm (r)Tj 0.443 g -0.035 Tc 8.817 0 0 9.4 404.55 574.33 Tm (espec)Tj 0.2 g 0 Tc 9.4 0 0 9.4 426.68 574.33 Tm (t )Tj /T1_0 1 Tf 10.9 0 0 10.9 434.37 574.33 Tm (t)Tj 0.365 0.365 0.361 rg 0.257 0 Td (o )Tj 0.282 g /T1_1 1 Tf -0.0108 Tc 9.4 0 0 9.4 447.18 574.33 Tm (normal )Tj -0.0332 Tc 3.574 0 Td (nonsmokers )Tj 0.365 0.365 0.361 rg -0.035 Tc 8.8407 0 0 9.4 299.43 563.28 Tm (and )Tj 9.0091 0 0 9.4 320.64 563.28 Tm (was )Tj 0.282 g -0.0229 Tc 9.4 0 0 9.4 343.02 563.28 Tm (in)Tj 0.443 g 0 Tc 0.773 0 Td (c)Tj 0.282 g 0.503 0 Td (r)Tj 0.443 g -0.035 Tc 8.6242 0 0 9.4 357.99 563.28 Tm (eased )Tj -0.0211 Tc 9.4 0 0 9.4 387.28 563.28 Tm (2.8-)Tj 0.282 g 0 Tc 1.743 0 Td (f)Tj 0.443 g 0.299 0 Td (o)Tj 0.282 g -0.0229 Tc 0.552 0 Td (ld )Tj 0.0215 Tc 1.551 0 Td (with )Tj ET BT /Suspect <>BDC 0.2 g /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 450.542 563.28 Tm (r)Tj 0.365 0.365 0.361 rg -0.035 Tc 9.2004 0 0 9.4 453.5 563.28 Tm (espec)Tj 0.2 g 0 Tc 9.4 0 0 9.4 476.6 563.28 Tm (t )Tj EMC ET BT 0.282 g /T1_1 1 Tf -0.0085 Tc 9.4 0 0 9.4 486.1974 563.28 Tm (to )Tj 0.2 g 0 Tc 1.517 0 Td (n)Tj 0.365 0.365 0.361 rg -0.0197 Tc 0.52 0 Td (ormal )Tj 0.443 g -0.035 Tc 9.2471 0 0 9.4 299.44 552.25 Tm (smokers. )Tj 0.365 0.365 0.361 rg 0.0137 Tc 9.4 0 0 9.4 338.82 552.25 Tm (The )Tj 0.01 Tc 2.2 0 Td (finding )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf -0.0252 Tc 9.4 0 0 9.4 392.118 552.25 Tm (that )Tj EMC /Suspect <>BDC -0.035 Tc 8.5004 0 0 9.4 411.8 552.25 Tm (th)Tj 0.443 g 0 Tc 9.4 0 0 9.4 418.94 552.25 Tm (e )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0108 Tc 9.4 0 0 9.4 427.9828 552.25 Tm (normal )Tj -0.035 Tc 9.236 0 0 9.4 460.7 552.25 Tm (apex-base )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0048 Tc 9.4 0 0 9.4 504.87 552.25 Tm (gradi\255)Tj EMC /Suspect <>BDC -0.035 Tc 9.0209 0 0 9.4 299.43 541.69 Tm (em )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 10.0238 0 0 9.4 316.23 541.69 Tm (of )Tj 0.443 g 0 Tc 9.4 0 0 9.4 328.69 541.69 Tm (c)Tj 0.282 g 0.503 0 Td (l)Tj 0.443 g -0.035 Tc 9.0908 0 0 9.4 335.91 541.69 Tm (earance )Tj 0.365 0.365 0.361 rg -0.0221 Tc 9.4 0 0 9.4 371.5 541.69 Tm (from )Tj 0.282 g -0.035 Tc 9.1076 0 0 9.4 395 541.69 Tm (th)Tj 0.443 g 0 Tc 9.4 0 0 9.4 402.62 541.69 Tm (e )Tj 0.2 g 0.962 0 Td (l)Tj 0.365 0.365 0.361 rg -0.035 Tc 9.2575 0 0 9.4 414.55 541.69 Tm (ungs )Tj -0.0179 Tc 9.4 0 0 9.4 438.06 541.69 Tm (is )Tj 0.0057 Tc 1.174 0 Td (lost )Tj 0.2 g 0.0282 Tc 2.043 0 Td (in )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf -0.0235 Tc 9.4 0 0 9.4 480.971 541.69 Tm (ARDS )Tj EMC ET BT /T1_1 1 Tf -0.0315 Tc 9.4 0 0 9.4 511.5022 541.69 Tm (may )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.1853 0 0 9.4 299.34 530.65 Tm (be )Tj 0.443 g 0 Tc 9.4 0 0 9.4 313.35 530.65 Tm (o)Tj 0.282 g 0.569 0 Td (f )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 9.3348 0 0 9.4 325.83 530.65 Tm (great )Tj EMC ET BT /T1_1 1 Tf -0.023 Tc 9.4 0 0 9.4 350.7 530.65 Tm (importance )Tj 0.282 g 0.0282 Tc 5.209 0 Td (in )Tj 0.443 g -0.0243 Tc 1.287 0 Td (suggesting )Tj 0.365 0.365 0.361 rg 0.0083 Tc 5.054 0 Td (diffuse )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0069 Tc 9.4 0 0 9.4 491.418 530.65 Tm (epithelial )Tj EMC /Suspect <>BDC -0.035 Tc 9.2102 0 0 9.4 299.43 519.6 Tm (damage, )Tj EMC ET BT /T1_1 1 Tf 0.0108 Tc 9.4 0 0 9.4 336.78 519.6 Tm (but )Tj 0.0057 Tc 1.787 0 Td (its )Tj 0.036 Tc 1.43 0 Td (utility )Tj -0.035 Tc 8.6612 0 0 9.4 393.99 519.6 Tm (as )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 406.46 519.6 Tm (a )Tj EMC /Suspect <>BDC 0.443 g -0.035 Tc 9.1384 0 0 9.4 415.12 519.6 Tm (separate )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg 0.003 Tc 9.4 0 0 9.4 451.98 519.6 Tm (predictor )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 10.5806 0 0 9.4 491.9 519.6 Tm (of )Tj -0.0023 Tc 9.4 0 0 9.4 504.49 519.6 Tm (ARDs )Tj -0.0179 Tc -21.773 -1.123 Td (is )Tj 0.0105 Tc 1.174 0 Td (limited )Tj -0.035 Tc 9.2957 0 0 9.4 343.1 509.04 Tm (at )Tj 0.282 g 9.1076 0 0 9.4 354.68 509.04 Tm (th)Tj 0.443 g 0 Tc 9.4 0 0 9.4 362.3 509.04 Tm (e )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.1587 0 0 9.4 371.34 509.04 Tm (present )Tj 0.2 g 0 Tc 9.4 0 0 9.4 404.6 509.04 Tm (t)Tj 0.443 g -0.0194 Tc 0.343 0 Td (ime )Tj 0.365 0.365 0.361 rg 0.0482 Tc 1.991 0 Td (by )Tj 0.282 g 0.0177 Tc 1.598 0 Td (two )Tj 0.365 0.365 0.361 rg 0.0123 Tc 2.037 0 Td (different )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.0181 Tc 9.4 0 0 9.4 499.0888 509.04 Tm (consi)Tj 0.282 g 0 Tc 2.3 0 Td (d)Tj 0.443 g 0.512 0 Td (\255)Tj EMC /Suspect <>BDC -0.023 Tc -24.053 -1.123 Td (erntions: )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0269 Tc 9.4 0 0 9.4 337.8788 498.4838 Tm (the )Tj 0.443 g -0.0252 Tc 1.68 0 Td (occurrence )Tj 0.05 Tc 10.5806 0 0 9.4 401.66 498.48 Tm (of )Tj 0.365 0.365 0.361 rg 0 Tc 9.4 0 0 9.4 414.14 498.48 Tm (a )Tj 0.443 g 0.0242 Tc 0.921 0 Td (similar )Tj 0.365 0.365 0.361 rg -0.0181 Tc 3.368 0 Td (event )Tj 0.0282 Tc 2.8 0 Td (in )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.035 Tc 9.2014 0 0 9.4 492.88 498.48 Tm (smokers)Tj 0.282 g 0 Tc 9.4 0 0 9.4 526.44 498.48 Tm (' )Tj EMC ET BT /T1_1 1 Tf 9.4 0 0 9.4 299.8154 487.4538 Tm (l)Tj 0.443 g -0.035 Tc 9.0201 0 0 9.4 302.71 487.45 Tm (ungs )Tj 0.0282 Tc 9.4 0 0 9.4 325.26 487.45 Tm (in )Tj 0.012 Tc 1.179 0 Td (CIPO )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 9.1455 0 0 9.4 363.27 487.45 Tm (and )Tj EMC ET BT /T1_1 1 Tf 9.1495 0 0 9.4 382.04 487.45 Tm (the )Tj -0.0175 Tc 9.4 0 0 9.4 398.22 487.45 Tm (lack )Tj 0.443 g 0.05 Tc 10.5806 0 0 9.4 418.46 487.45 Tm (of )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.025 Tc 9.4 0 0 9.4 430.47 487.45 Tm (data )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 9.0913 0 0 9.4 451.59 487.45 Tm (on )Tj -0.0269 Tc 9.4 0 0 9.4 466.04 487.45 Tm (the )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0159 Tc 9.4 0 0 9.4 481.879 487.45 Tm (time-course )Tj EMC ET BT 0.443 g /T1_1 1 Tf 0.05 Tc 10.5806 0 0 9.4 299.42 476.88 Tm (of )Tj 0.365 0.365 0.361 rg 0.0091 Tc 9.4 0 0 9.4 311.79 476.88 Tm (PAEP )Tj 0.282 g 0.0282 Tc 3.118 0 Td (in )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.1495 0 0 9.4 353.72 476.88 Tm (the )Tj 0.443 g 0.0004 Tc 9.4 0 0 9.4 369.5 476.88 Tm (early )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 8.8407 0 0 9.4 393.99 476.88 Tm (and )Tj EMC ET BT /T1_1 1 Tf -0.0193 Tc 9.4 0 0 9.4 413.1 476.88 Tm (prcclinicaJ )Tj -0.035 Tc 9.0277 0 0 9.4 460.15 476.88 Tm (phase )Tj 0.05 Tc 10.5806 0 0 9.4 487.1 476.88 Tm (of )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0024 Tc 9.4 0 0 9.4 500.17 476.88 Tm (ARDS. )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.8048 0 0 10.2 299.93 465.85 Tm (In )Tj 0.443 g /T1_1 1 Tf -0.0135 Tc 9.4 0 0 9.4 311.41 465.85 Tm (conclusion, )Tj 0.365 0.365 0.361 rg 0.05 Tc 12.2654 0 0 9.4 361.2 465.85 Tm (if )Tj 0.443 g -0.035 Tc 9.1121 0 0 9.4 370.47 465.85 Tm (an )Tj 0.0038 Tc 9.4 0 0 9.4 383.9 465.85 Tm (effective )Tj 0.282 g -0.0278 Tc 4.143 0 Td (therapeuti)Tj 0.443 g 0 Tc 4.231 0 Td (c )Tj 0.365 0.365 0.361 rg -0.0065 Tc 0.912 0 Td (intervention )Tj -0.0179 Tc 5.515 0 Td (is )Tj -0.0272 Tc -23.728 -1.176 Td (found )Tj -0.0079 Tc 2.89 0 Td (PAEP )Tj -0.035 Tc 8.8399 0 0 9.4 355.59 454.8 Tm (assessment )Tj 0.0114 Tc 9.4 0 0 9.4 404.46 454.8 Tm (might )Tj -0.035 Tc 9.1853 0 0 9.9 432.3 454.8 Tm (be )Tj /T1_0 1 Tf 0 Tc 11.4 0 0 11.4 445.8 454.8 Tm (a )Tj 0.282 g /T1_1 1 Tf 0.05 Tc 12.2959 0 0 9.4 454.81 454.8 Tm (lif)Tj 0.443 g -0.0185 Tc 9.4 0 0 9.4 463.58 454.8 Tm (e-saving )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.0069 Tc 9.4 0 0 9.4 502.0354 454.8 Tm (tool )Tj EMC ET BT /T1_1 1 Tf 0.0282 Tc 9.4 0 0 9.4 521.578 454.8 Tm (in )Tj -0.035 Tc 9.1495 0 0 9.4 299.96 444.25 Tm (the )Tj 0.0171 Tc 9.4 0 0 9.4 319.66 444.25 Tm (first )Tj ET BT /Suspect <>BDC 0.443 g /T1_1 1 Tf -0.0134 Tc 9.4 0 0 9.4 342.643 444.25 Tm (six )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 9.2348 0 0 9.4 361.83 444.25 Tm (days )Tj 0.443 g 0.05 Tc 10.5806 0 0 9.4 387.74 444.25 Tm (of )Tj 0.365 0.365 0.361 rg -0.0222 Tc 9.4 0 0 9.4 404.12 444.25 Tm (this )Tj -0.0143 Tc 2.351 0 Td (fatal )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0144 Tc 10.5 0 0 10.5 451.1 444.25 Tm (disease )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 9.045 0 0 9.4 488.16 444.25 Tm (when )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.4562 0 0 10.5 517.41 444.25 Tm (tbe )Tj EMC /Suspect <>BDC 0.282 g /T1_1 1 Tf -0.0064 Tc 9.4 0 0 9.4 299.82 433.2 Tm (mortal)Tj 0.443 g 0 Tc 2.809 0 Td (i)Tj 0.282 g 0.27 0 Td (t)Tj 0.443 g 0.306 0 Td (y )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 9.4 0 0 9.4 340.1366 433.2 Tm (i )Tj -0.035 Tc 8.676 0 0 9.4 350.31 433.2 Tm (at )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 8.6467 0 0 9.4 361.75 433.2 Tm (itS )Tj EMC /Suspect <>BDC -0.0173 Tc 9.4 0 0 9.4 375.18 433.2 Tm (lowest )Tj EMC ET BT /T1_1 1 Tf -0.0188 Tc 9.4 0 0 9.4 404.9404 433.2 Tm (level )Tj -0.0193 Tc 2.501 0 Td ([35, )Tj 0.443 g -0.0019 Tc 2.051 0 Td (36]. )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_2 1 Tf 0.047 Tc 8.2 0 0 8.2 357.73 415.93 Tm (Acknowkdgmtnts)Tj 0.6 0.6 0.596 rg 0 Tc 7.413 0 Td (; )Tj EMC /Suspect <>BDC 0.443 g /T1_1 1 Tf 0.0213 Tc 7.4001 0 0 7.4001 424.75 415.93 Tm (The )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf 0.0226 Tc 7.6 0 0 7.6 442.07 415.93 Tm (writers )Tj EMC /Suspect <>BDC 0.0292 Tc 3.53 0 Td (lha)Tj 0.71 g 0 Tc 1.187 0 Td (.)Tj 0.365 0.365 0.361 rg -0.035 Tc 7.4868 0 0 7.6 479.03 415.93 Tm (nk )Tj EMC ET BT /T1_0 1 Tf -0.0261 Tc 7.6 0 0 7.6 491.48 415.93 Tm (E. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0355 Tc 7.6 0 0 7.6 502.538 415.93 Tm (Zanneui )Tj EMC /Suspect <>BDC 0.0074 Tc -20.218 -1.137 Td (for )Tj EMC /Suspect <>BDC 0.05 Tc 7.6963 0 0 7.6 360.95 407.29 Tm (her )Tj EMC /Suspect <>BDC 0.443 g 0.0493 Tc 7.6 0 0 7.6 373.84 407.29 Tm (aulst.tncc )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 7.9356 0 0 9.2 408.9 407.29 Tm (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0228 Tc 7.6 0 0 7.6 418.06 407.29 Tm (the )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg 0.05 Tc 7.6479 0 0 7.6 430.57 407.29 Tm (preparuion )Tj EMC /Suspect <>BDC 0.443 g 8.9033 0 0 7.6 469.84 407.29 Tm (of )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg /T1_1 1 Tf -0.035 Tc 7.3196 0 0 7.7 479.97 407.29 Tm (the )Tj EMC /Suspect <>BDC /T1_0 1 Tf 8.5058 0 0 9.2 492.46 407.29 Tm (manuscript)Tj 0.537 g 0 Tc 9.2 0 0 9.2 527.33 407.29 Tm (. )Tj EMC ET BT 0.2 g /T1_1 1 Tf -0.0232 Tc 9.4 0 0 9.4 393.38 376.57 Tm (Ref)Tj 0.365 0.365 0.361 rg -0.035 Tc 8.8807 0 0 9.4 406.47 376.57 Tm (ere)Tj 0.2 g 8.8123 0 0 9.4 418.87 376.57 Tm (nc)Tj 0.365 0.365 0.361 rg 7.2199 0 0 9.4 428.09 376.57 Tm (es )Tj 0.2 g /T1_0 1 Tf 0 Tc 8.6 0 0 8.6 300.66 356.88 Tm (1)Tj 0.443 g 0.46 0 Td (. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.9097 0 0 9.2 313.91 356.88 Tm (U.C.)Tj 0.282 g 0 Tc 9.2 0 0 9.2 330.67 356.88 Tm (L)Tj 0.443 g -0.035 Tc 8.6534 0 0 9.2 336.3 356.88 Tm (.A. )Tj EMC /Suspect <>BDC 9.086 0 0 9.2 351.27 356.88 Tm (Co)Tj 0.282 g -0.0135 Tc 9.2 0 0 9.2 361.91 356.88 Tm (nfer)Tj 0.443 g -0.0322 Tc 1.555 0 Td (ence. )Tj EMC ET BT 0.537 g /T1_0 1 Tf 0 Tc 9.2 0 0 9.2 398.7652 356.88 Tm (-)Tj ET BT /Suspect <>BDC 0.282 g /T1_0 1 Tf 9.2 0 0 9.2 408.4344 356.88 Tm (R)Tj 0.443 g -0.0129 Tc 0.62 0 Td (ecent )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0056 Tc 9.2 0 0 9.2 437.1844 356.88 Tm (developments )Tj 0.282 g -0.0304 Tc 6.001 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0102 Tc 9.2 0 0 9.2 503.5256 356.88 Tm (pulmo)Tj 0.6 0.6 0.596 rg 0 Tc 2.439 0 Td (\255)Tj EMC /Suspect <>BDC 0.282 g -0.0103 Tc -24.563 -1.096 Td (nar)Tj 0.443 g 0 Tc 1.2 0 Td (y )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg -0.0205 Tc 0.877 0 Td (edema)Tj 0.537 g 0 Tc 2.599 0 Td (. )Tj EMC /Suspect <>BDC 0.71 g /T1_3 1 Tf 8.4 0 0 8.4 346.25 346.8 Tm (')Tj 0.282 g 0.0012 Tc 0.215 0 Td (Ann )Tj EMC /Suspect <>BDC 0.0499 Tc 2.148 0 Td (Int)Tj 0.443 g 0.0031 Tc 1.144 0 Td (ern )Tj EMC ET BT 0.282 g /T1_3 1 Tf 0.0006 Tc 8.4 0 0 8.4 391.0892 346.8 Tm (Med)Tj 0.443 g 0 Tc 2.006 0 Td (, )Tj 0.2 g /T1_0 1 Tf 9.6 0 0 9.6 413.91 346.8 Tm (1)Tj 0.365 0.365 0.361 rg -0.035 Tc 9.481 0 0 9.6 417.49 346.8 Tm (983, )Tj 9.1421 0 0 9.6 437.18 346.8 Tm (99. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0068 Tc 9.6 0 0 9.6 451.51 346.8 Tm (808-822. )Tj EMC /Suspect <>BDC 0.443 g -0.035 Tc 8.0417 0 0 10 299.43 336.73 Tm ('2. )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0227 Tc 9.2 0 0 9.2 313.4 336.73 Tm (Bnchofen )Tj ET BT /Suspect <>BDC 0.282 g /T1_1 1 Tf 0.05 Tc 8.6099 0 0 8.5 351.65 336.73 Tm (M, )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0222 Tc 9.2 0 0 9.2 365.73 336.73 Tm (Weibel )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 8.4076 0 0 8.5 395.33 336.73 Tm (ER)Tj 0.6 0.6 0.596 rg 0 Tc 8.5 0 0 8.5 406.81 336.73 Tm (. )Tj EMC ET BT 0.537 g /T1_1 1 Tf 8.5 0 0 8.5 412.2415 336.73 Tm (-)Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0106 Tc 9.2 0 0 9.2 421.27 336.73 Tm (Structural )Tj EMC ET BT /T1_0 1 Tf -0.0078 Tc 9.2 0 0 9.2 460.7104 336.73 Tm (alterations )Tj 0.443 g 0 Tc 4.487 0 Td (o)Tj 0.282 g 0.521 0 Td (f )Tj 0.365 0.365 0.361 rg -0.0307 Tc 0.733 0 Td (lung )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0139 Tc 9.2 0 0 9.2 300.014 327.1344 Tm (parenchyma )Tj EMC ET BT 0.443 g /T1_0 1 Tf -0.035 Tc 8.5969 0 0 9.2 348.41 327.13 Tm (in )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0088 Tc 9.2 0 0 9.2 359.5 327.13 Tm (the )Tj EMC /Suspect <>BDC -0.0269 Tc 1.662 0 Td (adult )Tj EMC ET BT 0.282 g /T1_0 1 Tf 0 Tc 9.2 0 0 9.2 396.9532 327.13 Tm (r)Tj 0.443 g -0.0069 Tc 0.303 0 Td (espiratory )Tj 0.365 0.365 0.361 rg -0.002 Tc 4.384 0 Td (distress )Tj -0.0121 Tc 3.439 0 Td (syndrome. )Tj ET BT /Suspect <>BDC 0.443 g /T1_2 1 Tf -0.0054 Tc 9.2 0 0 9.2 513.4252 327.13 Tm (Cli)Tj 0.282 g 0 Tc 1.214 0 Td (n )Tj EMC /Suspect <>BDC 0.443 g -0.035 Tc 8.1462 0 0 9.7 299.36 316.57 Tm (CJaest )Tj EMC ET BT 0.282 g /T1_3 1 Tf 0 Tc 8.4 0 0 8.4 323.41 316.57 Tm (M)Tj 0.443 g -0.035 Tc 7.7751 0 0 8.4 331.08 316.57 Tm (ed. )Tj 0.365 0.365 0.361 rg /T1_0 1 Tf 8.9474 0 0 9.6 346.25 316.57 Tm (1982, )Tj 0.443 g -0.0133 Tc 9.2 0 0 9.2 368.53 316.57 Tm (3\(1\), )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.023 Tc 9.2 0 0 9.2 389.1656 316.57 Tm (35-56. )Tj EMC ET BT /T1_1 1 Tf -0.0255 Tc 8.6 0 0 8.6 299.42 306.97 Tm (3. )Tj 0.365 0.365 0.361 rg /T1_0 1 Tf -0.035 Tc 9.0168 0 0 9.2 313.88 306.97 Tm (Hyers )Tj /T1_1 1 Tf 0.05 Tc 9.0821 0 0 8.6 336.9 306.97 Tm (TM)Tj 0.537 g 0 Tc 8.6 0 0 8.6 351.13 306.97 Tm (. )Tj 0.6 0.6 0.596 rg 0.576 0 Td (-)Tj ET BT /Suspect <>BDC 0.282 g /T1_0 1 Tf -0.035 Tc 8.6017 0 0 9.2 364.28 306.97 Tm (Pa)Tj 0.443 g -0.0278 Tc 9.2 0 0 9.2 373.42 306.97 Tm (thogenesis )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.4598 0 0 9.2 413.19 306.97 Tm (of )Tj 0.365 0.365 0.361 rg -0.0269 Tc 9.2 0 0 9.2 424.23 306.97 Tm (adult )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0169 Tc 9.2 0 0 9.2 444.8656 306.97 Tm (distress )Tj EMC ET BT 0.443 g /T1_0 1 Tf -0.0286 Tc 9.2 0 0 9.2 475.0692 306.97 Tm (syndrome: )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0079 Tc 9.2 0 0 9.2 514.9512 306.97 Tm (cur\255)Tj EMC ET BT 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0132 Tc 9.2 0 0 9.2 299.5148 297.3744 Tm (rent )Tj ET BT /Suspect <>BDC 0.537 g /T1_0 1 Tf -0.0026 Tc 9.2 0 0 9.2 316.7188 297.3744 Tm (concepts. )Tj EMC /Suspect <>BDC 0.443 g /T1_2 1 Tf 0.0062 Tc 9.1 0 0 9.1 353.75 297.37 Tm (Sem )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg 0.0065 Tc 2.066 0 Td (Respir )Tj EMC ET BT /T1_2 1 Tf -0.0202 Tc 9.1 0 0 9.1 399.4502 297.37 Tm (Med, )Tj /T1_0 1 Tf -0.035 Tc 9.1828 0 0 9.6 422.08 297.37 Tm (1981, )Tj 0.443 g 8.9643 0 0 9.6 444.91 297.37 Tm (2, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.1511 0 0 9.6 455.68 297.37 Tm (104. )Tj EMC ET BT /T1_0 1 Tf 0.012 Tc 9 0 0 9 299.48 287.29 Tm (4. )Tj 0.365 0.365 0.361 rg -0.035 Tc 9.1122 0 0 9.2 313.48 287.29 Tm (Nash )Tj 0.443 g 8.8509 0 0 9.2 335.43 287.29 Tm (G. )Tj 0.365 0.365 0.361 rg -0.0299 Tc 9.2 0 0 9.2 348.44 287.29 Tm (Foley )Tj -0.035 Tc 8.9947 0 0 9.2 372.92 287.29 Tm (FD, )Tj ET BT /Suspect <>BDC 0.443 g /T1_0 1 Tf -0.0149 Tc 9.2 0 0 9.2 390.67 287.29 Tm (Langlinais )Tj EMC /Suspect <>BDC 0.282 g 0 Tc 4.54 0 Td (P)Tj 0.443 g -0.035 Tc 8.9365 0 0 9.2 437.19 287.29 Tm (C. )Tj EMC ET BT 0.537 g /T1_0 1 Tf 0 Tc 9.2 0 0 9.2 449.17 287.29 Tm (-)Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0115 Tc 9.2 0 0 9.2 457.8824 287.29 Tm (Pulmonary )Tj EMC /Suspect <>BDC 0.021 Tc 4.743 0 Td (intenti)Tj 0.537 g 0 Tc 2.71 0 Td (\255)Tj EMC ET BT 0.443 g /T1_0 1 Tf -0.035 Tc 8.6402 0 0 8.9 299.98 277.2 Tm (tial )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0205 Tc 9.2 0 0 9.2 313.82 277.2 Tm (edema )Tj EMC /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 8.6084 0 0 8.6 340.61 277.2 Tm (Md )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0237 Tc 9.2 0 0 9.2 356.63 277.2 Tm (hyalme )Tj EMC ET BT /T1_0 1 Tf -0.0207 Tc 9.2 0 0 9.2 385.4168 277.2 Tm (membranes )Tj -0.0304 Tc 4.793 0 Td (in )Tj 0.443 g -0.0139 Tc 1.095 0 Td (adult )Tj 0.365 0.365 0.361 rg -0.0228 Tc 2.307 0 Td (bum )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0304 Tc 9.2 0 0 9.2 480.4896 277.2 Tm (patients: )Tj EMC /Suspect <>BDC /C0_0 1 Tf 0 Tc 5.76 0 0 7.2 512.65 277.2 Tm <0065006C007E0020>Tj EMC /Suspect <>BDC 0.443 g /T1_0 1 Tf 0.0241 Tc 8 0 0 8 299.98 268.09 Tm (tron )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0126 Tc 9.2 0 0 9.2 317.26 268.09 Tm (microscope )Tj ET BT /Suspect <>BDC 0.443 g /T1_0 1 Tf -0.0115 Tc 9.2 0 0 9.2 361.3464 268.09 Tm (observations)Tj 0.6 0.6 0.596 rg 0 Tc 4.998 0 Td (. )Tj EMC /Suspect <>BDC 0.282 g /T1_2 1 Tf -0.0132 Tc 9.1 0 0 9.1 412.4 268.09 Tm (Hum )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg -0.0127 Tc 2.32 0 Td (Pathol, )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.4758 0 0 9.6 463.35 268.09 Tm (1974)Tj 0.2 g 0 Tc 9.6 0 0 9.6 480.81 268.09 Tm (, )Tj 0.365 0.365 0.361 rg /T1_2 1 Tf -0.035 Tc 8.2535 0 0 9.1 486.64 268.09 Tm (5, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0231 Tc 9.6 0 0 9.6 496.95 268.09 Tm (149-160. )Tj EMC ET BT 0.443 g /T1_2 1 Tf -0.035 Tc 9.629 0 0 10 299.42 257.53 Tm (5. )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0147 Tc 9.2 0 0 9.2 313.4 257.53 Tm (Barret )Tj EMC ET BT 0.443 g /T1_0 1 Tf -0.035 Tc 8.969 0 0 9.2 339.75 257.53 Tm (GR )Tj 0.365 0.365 0.361 rg 9.1291 0 0 9.2 356.59 257.53 Tm (Jr. )Tj 9.0602 0 0 9.2 370.04 257.53 Tm (Bell )Tj 0 Tc 9.2 0 0 9.2 388.78 257.53 Tm (A )Tj 0.443 g -0.0124 Tc 1.145 0 Td (Jr. )Tj 0.365 0.365 0.361 rg -0.024 Tc 1.462 0 Td (Ryan )Tj ET BT /Suspect <>BDC 0.443 g /T1_0 1 Tf 0 Tc 9.2 0 0 9.2 435.6724 257.53 Tm (S)Tj 0.282 g 0.588 0 Td (F)Tj 0.537 g 0.558 0 Td (. )Tj EMC ET BT 0.443 g /T1_0 1 Tf 9.2 0 0 9.2 452.0576 257.53 Tm (-)Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.01 Tc 9.2 0 0 9.2 461.2668 257.53 Tm (Alveolar-epithelial )Tj EMC ET BT 0.443 g /T1_0 1 Tf -0.035 Tc 9.1514 0 0 9.2 299.92 247.45 Tm (inJury )Tj -0.001 Tc 9.2 0 0 9.2 325.35 247.45 Tm (causing )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.9201 0 0 9.2 358.07 247.45 Tm (respirac.ory )Tj EMC /Suspect <>BDC -0.002 Tc 9.2 0 0 9.2 401.19 247.45 Tm (distress )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.5969 0 0 9.2 433.85 247.45 Tm (in )Tj 0.0023 Tc 9.2 0 0 9.2 444.87 247.45 Tm (dogs. )Tj 0.365 0.365 0.361 rg -0.0165 Tc 2.718 0 Td (Physiologic )Tj -0.0116 Tc 5.055 0 Td (and )Tj ET BT /Suspect <>BDC 0.443 g /T1_0 1 Tf -0.0094 Tc 9.2 0 0 9.2 299.4088 237.836 Tm (electron)Tj 0.6 0.6 0.596 rg 0 Tc 3.182 0 Td (-)Tj 0.443 g -0.0126 Tc 0.323 0 Td (microscope )Tj EMC /Suspect <>BDC -0.0035 Tc 4.845 0 Td (correlauons. )Tj EMC /Suspect <>BDC /T1_2 1 Tf -0.0073 Tc 9.1 0 0 9.1 424.62 237.84 Tm (Chest, )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_0 1 Tf -0.035 Tc 9.4183 0 0 9.6 451.83 237.84 Tm (1979, )Tj 0.443 g -0.0127 Tc 9.2 0 0 9.2 474.62 237.84 Tm (75, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0155 Tc 9.6 0 0 9.6 489.5 237.84 Tm (705-711. )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 8.072 0 0 8.5 299.43 227.77 Tm (6. )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0225 Tc 9.2 0 0 9.2 313.4 227.77 Tm (Brigham )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 8.5253 0 0 8.5 349.26 227.77 Tm (KL. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0086 Tc 9.2 0 0 9.2 367.64 227.77 Tm (Mcyn)Tj 0.537 g 0.0162 Tc 2.342 0 Td (ck )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_1 1 Tf 0 Tc 8.5 0 0 8.5 402.54 227.77 Tm (B)Tj 0.6 0.6 0.596 rg 0.728 0 Td [(. )-139(-)]TJ ET BT /Suspect <>BDC 0.443 g /T1_0 1 Tf 0.0053 Tc 9.2 0 0 9.2 423.67 227.77 Tm (State )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.0163 0 0 9.2 445.82 227.77 Tm (of )Tj 0.0294 Tc 8 0 0 8 458.8 227.77 Tm (art. )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.035 Tc 8.6921 0 0 9.2 475.15 227.77 Tm (Endoc.oxin )Tj EMC /Suspect <>BDC 0.443 g 9.1634 0 0 9.2 516.39 227.77 Tm (and )Tj EMC ET BT /T1_0 1 Tf -0.0133 Tc 9.2 0 0 9.2 299.44 217.69 Tm (lung )Tj -0.015 Tc 2.139 0 Td (injury)Tj 0.6 0.6 0.596 rg 0 Tc 2.336 0 Td (. )Tj 0.443 g /T1_2 1 Tf -0.0272 Tc 9.6 0 0 9.6 345.75 217.69 Tm (Am )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_2 1 Tf 0.0183 Tc 9.1 0 0 9.1 361.51 217.69 Tm (Rev )Tj EMC /Suspect <>BDC 0.05 Tc 9.7047 0 0 9.1 378.31 217.69 Tm (Rupir )Tj EMC /Suspect <>BDC 0.443 g -0.035 Tc 9.3713 0 0 9.6 405.21 217.69 Tm (Dis. )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_0 1 Tf 9.4183 0 0 9.6 423.99 217.69 Tm (1986. )Tj 9.1511 0 0 9.6 448 217.69 Tm (133, )Tj 0.443 g -0.0083 Tc 9.6 0 0 9.6 466.45 217.69 Tm (913-927. )Tj /T1_3 1 Tf -0.0018 Tc 8.8 0 0 8.8 299.13 208.09 Tm (1. )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0254 Tc 9.2 0 0 9.2 312.92 208.09 Tm (Mason )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.4898 0 0 9.2 342.2 208.09 Tm (RJ)Tj 0.6 0.6 0.596 rg 0 Tc 9.2 0 0 9.2 351.65 208.09 Tm [(. )-135(-)]TJ ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0115 Tc 9.2 0 0 9.2 367.1612 208.09 Tm (Pulmonary )Tj EMC /Suspect <>BDC 0.443 g 0.0043 Tc 4.742 0 Td (alveolar )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg 0.0014 Tc 3.66 0 Td (type )Tj EMC ET BT /T1_1 1 Tf 0 Tc 8.6 0 0 8.6 464.54 208.09 Tm (0 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0329 Tc 8.3 0 0 8.3 474.63 208.09 Tm (epithelial )Tj EMC /Suspect <>BDC 0.443 g 0.0043 Tc 9.2 0 0 9.2 512.07 208.09 Tm (cells )Tj EMC /Suspect <>BDC -0.035 Tc 9.1634 0 0 9.2 299.43 198.01 Tm (and )Tj EMC ET BT /T1_0 1 Tf -0.0139 Tc 9.2 0 0 9.2 315.75 198.01 Tm (adult )Tj -0.0154 Tc 2.252 0 Td (rcsptratory )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0095 Tc 9.2 0 0 9.2 377.666 198.01 Tm (distress )Tj EMC ET BT /T1_0 1 Tf -0.0154 Tc 9.2 0 0 9.2 407.8696 198.01 Tm (syndrome )Tj -0.0151 Tc 4.176 0 Td (\(clinical )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0215 Tc 9.2 0 0 9.2 478.958 198.01 Tm (investigation\). )Tj EMC /Suspect <>BDC 0.365 0.365 0.361 rg /T1_2 1 Tf -0.035 Tc 8.9224 0 0 9.6 299.68 187.45 Tm (We)Tj 0.6 0.6 0.596 rg 0 Tc 9.6 0 0 9.6 310.47 187.45 Tm (.)Tj 0.443 g -0.035 Tc 7.5813 0 0 9.6 311.28 187.45 Tm (\\1 )Tj EMC ET BT /T1_3 1 Tf 0 Tc 8.7 0 0 8.7 319.6 187.45 Tm (J )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_2 1 Tf 0.0003 Tc 9.6 0 0 9.6 327.46 187.45 Tm (Mtd. )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.1828 0 0 9.6 350.08 187.45 Tm (1985. )Tj 0.443 g 9.1511 0 0 9.6 373.6 187.45 Tm (143, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0097 Tc 9.6 0 0 9.6 392.04 187.45 Tm (611-615)Tj 0.6 0.6 0.596 rg 0 Tc 3.342 0 Td (. )Tj EMC ET BT 0.443 g /T1_0 1 Tf -0.035 Tc 9.1779 0 0 9.2 299.36 178.33 Tm (8. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0273 Tc 9.2 0 0 9.2 313.39 178.33 Tm (Lachmonn )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.0406 0 0 9.8 355.5 178.33 Tm (8, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0286 Tc 9.2 0 0 9.2 368.6 178.33 Tm (Dam)Tj 0.6 0.6 0.596 rg 0 Tc 1.862 0 Td (.)Tj 0.365 0.365 0.361 rg -0.035 Tc 7.1239 0 0 9.2 387.35 178.33 Tm (miiSUI )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.2 0 0 9.2 412.27 178.33 Tm (E)Tj 0.537 g (. )Tj 0.6 0.6 0.596 rg 1.298 0 Td (-)Tj 0.443 g -0.0197 Tc 1.053 0 Td (Adult )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0102 Tc 9.2 0 0 9.2 458.868 178.33 Tm (respiratory )Tj EMC /Suspect <>BDC -0.0095 Tc 4.687 0 Td (distress )Tj EMC ET BT /T1_0 1 Tf -0.0154 Tc 9.2 0 0 9.2 299.386 168.2468 Tm (syndrome)Tj 0.6 0.6 0.596 rg 0 Tc 3.907 0 Td (. )Tj 0.365 0.365 0.361 rg /T1_2 1 Tf -0.035 Tc 8.6797 0 0 9.8 342.33 168.25 Tm (In)Tj 0.6 0.6 0.596 rg 0 Tc 9.8 0 0 9.8 349.75 168.25 Tm (: )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0181 Tc 9.2 0 0 9.2 357.56 168.25 Tm (Pulmonary )Tj EMC ET BT 0.443 g /T1_0 1 Tf -0.0058 Tc 9.2 0 0 9.2 401.628 168.25 Tm (surfactant)Tj 0.6 0.6 0.596 rg 0 Tc 3.907 0 Td (. )Tj 0.365 0.365 0.361 rg -0.035 Tc 8.9365 0 0 9.2 444.92 168.25 Tm (B. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0086 Tc 9.2 0 0 9.2 457.88 168.25 Tm (Robertson. )Tj EMC ET BT /T1_1 1 Tf 0.0099 Tc 8.6 0 0 8.6 502.86 168.25 Tm (L.G.M. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0094 Tc 8.3 0 0 8.3 299.98 158.17 Tm (Van )Tj EMC /Suspect <>BDC 0.443 g -0.0067 Tc 9.2 0 0 9.2 320.07 158.17 Tm (Golde )Tj EMC /Suspect <>BDC -0.035 Tc 9.1634 0 0 9.2 347.91 158.17 Tm (and )Tj EMC ET BT 0.282 g /T1_0 1 Tf 0.05 Tc 11.7095 0 0 9.6 366.17 158.17 Tm (JJ)Tj 0.6 0.6 0.596 rg 0 Tc 9.6 0 0 9.6 376.12 158.17 Tm (. )Tj 0.365 0.365 0.361 rg -0.0089 Tc 9.2 0 0 9.2 383.96 158.17 Tm (Batenburg )Tj ET BT /Suspect <>BDC 0.443 g /T1_0 1 Tf 0.0384 Tc 8.3 0 0 8.3 427.12 158.17 Tm (cds, )Tj EMC ET BT 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0147 Tc 9.2 0 0 9.2 447.79 158.17 Tm (Elsevier, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0397 Tc 8.3 0 0 8.3 485.27 158.17 Tm (Amsterdam, )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.4183 0 0 9.6 299.67 147.61 Tm (1984, )Tj 0.0056 Tc 9.2 0 0 9.2 322.57 147.61 Tm (pp. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.007 Tc 9.6 0 0 9.6 337.31 147.61 Tm (505-548. )Tj EMC ET BT /T1_0 1 Tf 0.0053 Tc 9.2 0 0 9.2 298.94 138.48 Tm (9. )Tj 0.282 g 0.0058 Tc 1.463 0 Td (Tate )Tj 0.365 0.365 0.361 rg -0.035 Tc 8.8648 0 0 9.2 333.56 138.48 Tm (RM, )Tj 0.282 g 9.1991 0 0 9.2 353.72 138.48 Tm (Repin)Tj 0.443 g 0 Tc 9.2 0 0 9.2 374.78 138.48 Tm (e )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf 0.0109 Tc 9.2 0 0 9.2 382.9772 138.48 Tm (IE. )Tj EMC ET BT 0.443 g /T1_0 1 Tf 0 Tc 9.2 0 0 9.2 398.286 138.48 Tm (-)Tj 0.365 0.365 0.361 rg -0.0127 Tc 1.008 0 Td (Neutrophils )Tj -0.0116 Tc 5.099 0 Td (and )Tj 0.282 g 0.0173 Tc 1.834 0 Td (the )Tj -0.0008 Tc 1.662 0 Td (adult )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0062 Tc 9.2 0 0 9.2 508.318 138.48 Tm (respi\255)Tj EMC ET BT /T1_0 1 Tf -0.0076 Tc 9.2 0 0 9.2 299.0364 128.406 Tm (ratory )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.002 Tc 9.2 0 0 9.2 325.836 128.406 Tm (distress )Tj EMC ET BT /T1_0 1 Tf -0.0121 Tc 9.2 0 0 9.2 358.4316 128.406 Tm (syndrome. )Tj /T1_2 1 Tf 0.0228 Tc 9.6 0 0 9.6 401.43 128.41 Tm (Am )Tj ET BT /Suspect <>BDC 0.282 g /T1_2 1 Tf -0.0081 Tc 9.1 0 0 9.1 419.59 128.41 Tm (Rev )Tj EMC ET BT /T1_2 1 Tf 0.0065 Tc 9.1 0 0 9.1 438.3087 128.41 Tm (Respir )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 9.3713 0 0 9.6 467.61 128.41 Tm (Dis, )Tj EMC ET BT /T1_0 1 Tf 9.1828 0 0 9.2 488.32 128.41 Tm (1983, )Tj 9.1511 0 0 9.2 513.76 128.41 Tm (128, )Tj 0.365 0.365 0.361 rg /T1_2 1 Tf 0.0181 Tc 9.1 0 0 9.1 298.95 117.84 Tm (552-559. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.0926 0 0 9.2 299.69 108.72 Tm (10. )Tj EMC ET BT 0.2 g /T1_0 1 Tf 8.4797 0 0 9.2 315.32 108.72 Tm (Ri)Tj 0.365 0.365 0.361 rg -0.0194 Tc 9.2 0 0 9.2 323.51 108.72 Tm (naldo )Tj 0.2 g 0 Tc 2.552 0 Td (J)Tj 0.365 0.365 0.361 rg -0.035 Tc 8.2744 0 0 9.2 350.83 108.72 Tm (E, )Tj 0.282 g 0 Tc 9.2 0 0 9.2 361.88 108.72 Tm (R)Tj 0.443 g -0.0275 Tc 0.621 0 Td (ogers )Tj 0.282 g -0.035 Tc 8.8555 0 0 9.2 390.2 108.72 Tm (RM)Tj 0.443 g 0 Tc 9.2 0 0 9.2 404.45 108.72 Tm [(. )-30(-)]TJ 0.282 g -0.0197 Tc 1.479 0 Td (Adult )Tj 0.2 g 0 Tc 2.505 0 Td (r)Tj 0.365 0.365 0.361 rg -0.0296 Tc 0.355 0 Td (es)Tj 0.2 g 0 Tc 0.847 0 Td (p)Tj 0.365 0.365 0.361 rg -0.0151 Tc 0.512 0 Td (iratory )Tj 0.282 g -0.0169 Tc 2.921 0 Td (distress )Tj ET BT /Suspect <>BDC 0.365 0.365 0.361 rg /T1_0 1 Tf -0.0265 Tc 9.2 0 0 9.2 513.9484 108.72 Tm (syn\255)Tj EMC ET BT 0.282 g /T1_0 1 Tf -0.0216 Tc 9.2 0 0 9.2 298.9444 98.6368 Tm (drome: )Tj 0.365 0.365 0.361 rg -0.0061 Tc 3.183 0 Td (changing )Tj -0.0045 Tc 4.017 0 Td (concepts )Tj 0.0222 Tc 3.913 0 Td (of )Tj 0.2 g -0.0309 Tc 1.253 0 Td (lun)Tj 0.365 0.365 0.361 rg 0 Tc 1.252 0 Td (g )Tj -0.015 Tc 0.939 0 Td (injury )Tj 0.282 g -0.035 Tc 9.1634 0 0 9.2 458.31 98.64 Tm (and )Tj 0.2 g -0.017 Tc 9.2 0 0 9.2 475.19 98.64 Tm (repair)Tj 0.365 0.365 0.361 rg 0 Tc 2.276 0 Td (. )Tj 0.282 g /T1_2 1 Tf 9.6 0 0 9.6 501.69 98.64 Tm (N )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0333 Tc 9.6 0 0 9.6 512.2308 98.64 Tm (Eng/ )Tj EMC ET BT /T1_3 1 Tf 0 Tc 8.6 0 0 8.6 298.48 88.56 Tm (J )Tj -0.0348 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(PN, )Tj EMC /Suspect <>BDC 0.004 Tc 1.895 0 Td (Sampson )Tj EMC /Suspect <>BDC -0.027 Tc 4.05 0 Td (P, )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0028 Tc 8.8 0 0 8.8 255.312 745.21 Tm (Hansen)Tj 0.306 0.31 0.302 rg 0 Tc 2.993 0 Td (\255)Tj 0.149 0.149 0.141 rg 0.0121 Tc -25.739 -1.091 Td (Flashen )Tj /T1_1 1 Tf -0.035 Tc 7.4375 0 0 8.6 89.71 735.61 Tm (J. )Tj ET BT /Suspect <>BDC 0.306 0.31 0.302 rg /T1_1 1 Tf 0 Tc 8.6 0 0 8.6 101.68 735.61 Tm (-)Tj EMC /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0086 Tc 8.8 0 0 8.8 113.24 735.61 Tm (Permeability )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.9033 0 0 8.8 166 735.61 Tm (of )Tj 0.0121 Tc 8.8 0 0 8.8 180.01 735.61 Tm (pulmonary )Tj 0.0153 Tc 5.17 0 Td (endothelium )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.731 0 0 8.4 276.94 735.61 Tm (to )Tj EMC ET BT /T1_0 1 Tf 0.0111 Tc 8.8 0 0 8.8 54.71 725.53 Tm (neutral )Tj -0.0069 Tc 3.427 0 Td (and )Tj 0.0218 Tc 1.909 0 Td (charged )Tj 0.0092 Tc 3.772 0 Td (macrophages. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0428 Tc 8.8 0 0 8.8 188.7692 725.53 Tm (Ann )Tj EMC ET BT /T1_2 1 Tf 0.05 Tc 9.1707 0 0 8.8 207.44 725.53 Tm (NY )Tj 0.0445 Tc 8.8 0 0 8.8 222.85 725.53 Tm (Acad )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0156 Tc 8.8 0 0 8.8 245.7476 725.53 Tm (Sci, )Tj EMC ET BT /T1_0 1 Tf -0.0128 Tc 8.8 0 0 8.8 264.6588 725.53 Tm (1982, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0218 Tc 8.8 0 0 8.8 54.682 716.4132 Tm (401, )Tj EMC ET BT /T1_0 1 Tf 0.0363 Tc 8.8 0 0 8.8 73.8748 716.4132 Tm (241-262. )Tj 0.0107 Tc -2.101 -1.145 Td (12. )Tj 0.149 0.149 0.141 rg 0.0352 Tc 1.666 0 Td (Brody )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0066 Tc 8.8 0 0 8.8 97.3972 706.3372 Tm (JS, )Tj EMC ET BT /T1_0 1 Tf 0.0102 Tc 8.8 0 0 8.8 112.7884 706.3372 Tm (Vaccaro )Tj 0.01 Tc 3.865 0 Td (CA, )Tj 0.149 0.149 0.141 rg 0.0133 Tc 2.188 0 Td (Hill )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0004 Tc 8.8 0 0 8.8 184.3764 706.3372 Tm (NS, )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0113 Tc 8.8 0 0 8.8 202.5396 706.3372 Tm (Rounds )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0467 Tc 8.8 0 0 8.8 234.0964 706.3372 Tm (S. )Tj EMC /Suspect <>BDC 0 Tc 1.316 0 Td (-)Tj EMC ET BT /T1_0 1 Tf 0.0124 Tc 8.8 0 0 8.8 254.8556 706.3372 Tm (Binding )Tj 0.05 Tc 10.0163 0 0 8.8 54.62 696.24 Tm (of )Tj 0.0218 Tc 8.8 0 0 8.8 66.63 696.24 Tm (charged )Tj 0.0063 Tc 3.817 0 Td (ferritin )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.4365 0 0 8.8 130.06 696.24 Tm (to )Tj EMC ET BT /T1_0 1 Tf 0.0175 Tc 8.8 0 0 8.8 141.03 696.24 Tm (alveolar )Tj 0.0103 Tc 3.827 0 Td (wall )Tj 0.0172 Tc 2.227 0 Td (components )Tj -0.0069 Tc 5.509 0 Td (and )Tj 0.028 Tc 1.909 0 Td (charge )Tj 0.0013 Tc -23.294 -1.09 Td (selectivity )Tj 0.05 Tc 8.9033 0 0 8.8 94.48 686.65 Tm (of )Tj 0.0089 Tc 8.8 0 0 8.8 104.62 686.65 Tm (macromolecular )Tj -0.0005 Tc 6.982 0 Td (transport )Tj 0.05 Tc 8.8796 0 0 8.8 200.57 686.65 Tm (in )Tj 0.0081 Tc 8.8 0 0 8.8 210.25 686.65 Tm (permeability )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0026 Tc 8.8 0 0 8.8 258.254 686.65 Tm (pulmo\255)Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0273 Tc 8.8 0 0 8.8 54.2348 676.5564 Tm (nary )Tj 0.22 0.22 0.216 rg 0.0216 Tc 2.282 0 Td (edema )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.4716 0 0 8.8 100.72 676.56 Tm (in )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf -0.0002 Tc 8.8 0 0 8.8 111.35 676.56 Tm (rats. )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_2 1 Tf 0.0114 Tc 8.8 0 0 8.8 129.9092 676.56 Tm (Circ )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_2 1 Tf 0.0188 Tc 8.8 0 0 8.8 148.8732 676.56 Tm (Res, )Tj /T1_0 1 Tf -0.0128 Tc 2.249 0 Td (1984, )Tj 0.22 0.22 0.216 rg /T1_2 1 Tf -0.035 Tc 9.0808 0 0 9.7 191.43 676.56 Tm (55, )Tj /T1_0 1 Tf 0.0282 Tc 8.8 0 0 8.8 206.58 676.56 Tm (155-167. )Tj 0.0107 Tc -17.236 -1.09 Td (13. )Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0005 Tc 8.8 0 0 8.8 70.5232 666.968 Tm (Pi)Tj 0.306 0.31 0.302 rg 0.0352 Tc 0.812 0 Td (etra )Tj EMC /Suspect <>BDC 0.22 0.22 0.216 rg 0.006 Tc 2.236 0 Td (GO. )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 118.4568 666.968 Tm (-)Tj 0.22 0.22 0.216 rg 0.0215 Tc 1.207 0 Td (Biology )Tj 0.05 Tc 9.4598 0 0 8.8 164.55 666.97 Tm (of )Tj 0.0133 Tc 8.8 0 0 8.8 178 666.97 Tm (disease. )Tj 0.011 Tc 3.941 0 Td (New )Tj 0.0101 Tc 2.606 0 Td (insights )Tj 0.0147 Tc 3.873 0 Td (into )Tj 0.0155 Tc -24.485 -1.092 Td (mechanisms )Tj 0.05 Tc 9.4598 0 0 8.8 105.03 657.36 Tm (of )Tj 0.0121 Tc 8.8 0 0 8.8 119.05 657.36 Tm (pulmonary )Tj 0.0109 Tc 5.116 0 Td (edema. )Tj 0.149 0.149 0.141 rg /T1_2 1 Tf 0.05 Tc 8.9869 0 0 8.9 195.45 657.36 Tm (Lab )Tj 0.22 0.22 0.216 rg 0.001 Tc 8.8 0 0 8.8 216.09 657.36 Tm (Invest, )Tj /T1_0 1 Tf 0.0008 Tc 3.447 0 Td (1984, )Tj 0.149 0.149 0.141 rg -0.0079 Tc 2.966 0 Td (51, )Tj 0.22 0.22 0.216 rg 0.0358 Tc -24.809 -1.144 Td (489-494. )Tj 0.149 0.149 0.141 rg 0.05 Tc 8.829 0 0 8.8 54.41 637.21 Tm (14)Tj 0.306 0.31 0.302 rg 0 Tc 8.8 0 0 8.8 63.66 637.21 Tm (. )Tj 0.22 0.22 0.216 rg 0.0059 Tc 0.724 0 Td (Jones )Tj 0.149 0.149 0.141 rg 0.0054 Tc 2.836 0 Td (JG, )Tj 0.0192 Tc 2.019 0 Td (Minty )Tj 0.05 Tc 9.15 0 0 8.8 139.64 637.21 Tm (BD)Tj 0.306 0.31 0.302 rg 0 Tc 8.8 0 0 8.8 152.98 637.21 Tm (, )Tj 0.149 0.149 0.141 rg 0.0259 Tc 0.828 0 Td (Lawler )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0275 Tc 8.8 0 0 8.8 190.996 637.21 Tm (P, )Tj EMC ET BT /T1_0 1 Tf 0.0012 Tc 8.8 0 0 8.8 203.9584 637.21 Tm (Hulands )Tj 0.22 0.22 0.216 rg 0.0249 Tc 3.976 0 Td (G, )Tj 0.0123 Tc 1.582 0 Td (Crawley )Tj 0.149 0.149 0.141 rg 0.0414 Tc -22.577 -1.091 Td (JCW)Tj 0.306 0.31 0.302 rg 0 Tc 2.063 0 Td (, )Tj 0.22 0.22 0.216 rg -0.007 Tc 0.668 0 Td (Veall )Tj 0.05 Tc 12.2985 0 0 8.8 100.85 627.61 Tm (N.-)Tj 0.0214 Tc 8.8 0 0 8.8 120.89 627.61 Tm (lncreased )Tj 0.0175 Tc 4.307 0 Td (alveolar )Tj 0.0138 Tc 3.655 0 Td (epithelial )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.003 Tc 8.8 0 0 8.8 228.0124 627.61 Tm (permeabi]jty )Tj EMC /Suspect <>BDC 0.0028 Tc 5.555 0 Td (in )Tj EMC ET BT /T1_0 1 Tf 0.0162 Tc 8.8 0 0 8.8 54.1596 617.534 Tm (cigarette )Tj 0.306 0.31 0.302 rg 0 Tc 3.924 0 Td (s)Tj 0.149 0.149 0.141 rg 0.0051 Tc 0.393 0 Td (mokers. )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_2 1 Tf 0.0052 Tc 8.8 0 0 8.8 124.4188 617.534 Tm (Lancet, )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.0008 Tc 3.447 0 Td (1980, )Tj EMC ET BT /T1_0 1 Tf -0.0199 Tc 8.8 0 0 8.8 178.5036 617.534 Tm (i, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0447 Tc 8.8 0 0 8.8 186.626 617.534 Tm (66-68. )Tj EMC ET BT /T1_0 1 Tf -0.0166 Tc 8.8 0 0 8.8 54.9164 607.4404 Tm (15. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0158 Tc 8.8 0 0 8.8 70.0084 607.4404 Tm (Oberd6rster )Tj EMC ET BT /T1_0 1 Tf 0.0249 Tc 8.8 0 0 8.8 116.0852 607.4404 Tm (G, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.6472 0 0 8.8 128.63 607.44 Tm (UteU )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0322 Tc 8.8 0 0 8.8 149.72 607.44 Tm (MJ, )Tj 0.22 0.22 0.216 rg 0.0122 Tc 1.964 0 Td (Morrow )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0088 Tc 8.8 0 0 8.8 200.1264 607.44 Tm (PE, )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0093 Tc 8.8 0 0 8.8 216.4504 607.44 Tm (Hyde )Tj 0.22 0.22 0.216 rg 0.0262 Tc 2.564 0 Td (RW, )Tj 0.149 0.149 0.141 rg 0.0316 Tc 2.292 0 Td (Weber )Tj 0.22 0.22 0.216 rg 0.0329 Tc -23.347 -1.09 Td (B. )Tj 0.149 0.149 0.141 rg 0 Tc 1.575 0 Td (-)Tj 0.22 0.22 0.216 rg 0.0217 Tc 1.098 0 Td (Bronchial )Tj 0.0204 Tc 4.74 0 Td (and )Tj 0.0175 Tc 2.073 0 Td (alveolar )Tj 0.0173 Tc 3.873 0 Td (absorption )Tj 0.05 Tc 9.4598 0 0 8.8 214.95 597.85 Tm (of )Tj 0.0127 Tc 8.8 0 0 8.8 227.93 597.85 Tm (inhaled )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 6.4001 0 0 6.4001 259.61 600.24 Tm (9)Tj 0.05 Tc 7.4692 0 0 6.4001 262.96 597.85 Tm (9"'Tc\255)Tj EMC /Suspect <>BDC 0.149 0.149 0.141 rg 0.0119 Tc 8.8 0 0 8.8 54.2 587.76 Tm (DTPA. )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_2 1 Tf 0.05 Tc 9.0617 0 0 8.8 82.7 587.76 Tm (Am )Tj 0.0444 Tc 8.8 0 0 8.8 98.47 587.76 Tm (Rev )Tj 0.0244 Tc 1.909 0 Td (Respir )Tj 0.0164 Tc 3.056 0 Td (Dis, )Tj 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0008 Tc 2.139 0 Td (1986, )Tj 0.22 0.22 0.216 rg 0.0041 Tc 2.673 0 Td (134, )Tj 0.0372 Tc 2.15 0 Td (944-950. )Tj 0.0107 Tc -16.932 -1.145 Td (16. )Tj 0.0296 Tc 1.723 0 Td (Ahmed )Tj 0.149 0.149 0.141 rg 0.05 Tc 8.805 0 0 8.8 99.3 577.68 Tm (IH)Tj 0.306 0.31 0.302 rg 0 Tc 8.8 0 0 8.8 108.82 577.68 Tm (, )Tj 0.149 0.149 0.141 rg 0.0474 Tc 0.61 0 Td (EL)Tj 0.306 0.31 0.302 rg 0 Tc 1.249 0 Td (-)Tj 0.149 0.149 0.141 rg 0.013 Tc 0.334 0 Td (Khatib )Tj 0.22 0.22 0.216 rg -0.029 Tc 3.163 0 Td (E, )Tj 0.149 0.149 0.141 rg -0.0081 Tc 1.255 0 Td (Logus )Tj 0.22 0.22 0.216 rg -0.035 Tc 9.2563 0 0 9.6 191.95 577.68 Tm (JW, )Tj 0.05 Tc 8.9933 0 0 8.8 209.24 577.68 Tm (Man )Tj -0.0008 Tc 8.8 0 0 8.8 229.35 577.68 Tm (GCW, )Tj 0.149 0.149 0.141 rg 0.0017 Tc 3.005 0 Td (Jacques )Tj 0.22 0.22 0.216 rg -0.0309 Tc -22.909 -1.09 Td (J, )Tj 0.0165 Tc 1.092 0 Td (Man )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0085 Tc 8.8 0 0 8.8 84.8012 568.088 Tm (SFP. )Tj EMC ET BT 0.306 0.31 0.302 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 105.9828 568.088 Tm (-)Tj 0.22 0.22 0.216 rg 0.0018 Tc 1.045 0 Td (Altered )Tj 0.0121 Tc 3.494 0 Td (pulmonary )Tj 0.0138 Tc 4.898 0 Td (epithelial )Tj 0.0131 Tc 4.266 0 Td (permeability )Tj 0.0028 Tc 5.664 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0174 Tc 8.8 0 0 8.8 53.6756 557.9944 Tm (canine )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0199 Tc 8.8 0 0 8.8 83.5164 557.9944 Tm (radiation )Tj 0.22 0.22 0.216 rg 0.0127 Tc 4.466 0 Td (lung )Tj 0.0086 Tc 2.564 0 Td (injury. )Tj /T1_3 1 Tf 0 Tc 8.6 0 0 8.6 175.12 558 Tm (J )Tj /T1_2 1 Tf 0.0453 Tc 8.8 0 0 8.8 185.89 558 Tm (Appl )Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /T1_2 1 Tf 0.0023 Tc 8.8 0 0 8.8 209.826 558 Tm (Physiol, )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0008 Tc 8.8 0 0 8.8 245.9324 558 Tm (1986, )Tj -0.0127 Tc 2.967 0 Td (61, )Tj 0.0372 Tc -24.817 -1.09 Td (971-981. )Tj 0.0107 Tc 0.032 -1.145 Td (17. )Tj 0.0182 Tc 1.722 0 Td (Welsh )Tj 0.0049 Tc 3.053 0 Td (MJ, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0293 Tc 8.8 0 0 8.8 113.114 538.332 Tm (Shasby )Tj EMC ET BT /T1_0 1 Tf 0.005 Tc 8.8 0 0 8.8 142.99 538.332 Tm (DM, )Tj 0.149 0.149 0.141 rg 0.0142 Tc 2.345 0 Td (Husted )Tj 0.22 0.22 0.216 rg 0.0015 Tc 3.273 0 Td (RF. )Tj ET BT /Suspect <>BDC 0.306 0.31 0.302 rg /T1_0 1 Tf 0.05 Tc 9.3399 0 0 8.8 209.17 538.33 Tm (-Oxidants )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0103 Tc 8.8 0 0 8.8 253.85 538.33 Tm (increase )Tj 0.0038 Tc -22.791 -1.147 Td (paraceUular )Tj 0.0131 Tc 5.236 0 Td (permeability )Tj 0.0028 Tc 5.609 0 Td (in )Tj 0 Tc 1.198 0 Td (a )Tj 0.0184 Tc 0.764 0 Td (cultured )Tj 0.0138 Tc 3.764 0 Td (epithelial )Tj 0.05 Tc 8.8666 0 0 8.8 235.59 528.24 Tm (cell )Tj 0.0034 Tc 8.8 0 0 8.8 252.41 528.24 Tm (line. )Tj /T1_2 1 Tf 0.05 Tc 9.4102 0 0 8.8 270.86 528.24 Tm (Am )Tj 0.0444 Tc 8.8 0 0 8.8 53.35 518.65 Tm (Rev )Tj 0.0244 Tc 1.909 0 Td (Respir )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0164 Tc 8.8 0 0 8.8 97.042 518.65 Tm (Dis, )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0008 Tc 8.8 0 0 8.8 115.8652 518.65 Tm (1985, )Tj 0.22 0.22 0.216 rg -0.0325 Tc 2.673 0 Td (131 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.001 Tc 8.8 0 0 8.8 156.3892 518.65 Tm (\(Suppl. )Tj EMC ET BT /T1_0 1 Tf 0.0116 Tc 8.8 0 0 8.8 185.7284 518.65 Tm (4\), )Tj 0 Tc 1.475 0 Td (A )Tj 0.0207 Tc 1.136 0 Td (36. )Tj -0.0166 Tc -17.586 -1.147 Td (18. )Tj 0.0172 Tc 1.72 0 Td (Kennedy )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0425 Tc 8.8 0 0 8.8 105.446 508.5564 Tm (SM, )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0135 Tc 8.8 0 0 8.8 124.7532 508.5564 Tm (Elwood )Tj -0.0269 Tc 3.656 0 Td (RK, )Tj 0.0176 Tc 2.074 0 Td (Wiggs )Tj 0 Tc 3.108 0 Td (B )Tj 0.22 0.22 0.216 rg 0.009 Tc 1.144 0 Td (Jr, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0134 Tc 8.8 0 0 8.8 225.566 508.5564 Tm (Pare )Tj EMC /Suspect <>BDC 0.149 0.149 0.141 rg 0.0464 Tc 2.236 0 Td (PD)Tj 0.306 0.31 0.302 rg 0 Tc 1.293 0 Td (. )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0085 Tc 8.8 0 0 8.8 263.0012 508.5564 Tm (Hogg )Tj 0.149 0.149 0.141 rg 0.0061 Tc -23.837 -1.144 Td (JC. )Tj 0.22 0.22 0.216 rg 0 Tc 1.685 0 Td (-)Tj 0.0214 Tc 0.931 0 Td (lncreased )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.015 Tc 8.8 0 0 8.8 114.6332 498.4892 Tm (airway )Tj EMC ET BT /T1_0 1 Tf 0.0095 Tc 8.8 0 0 8.8 142.5468 498.4892 Tm (mucosal )Tj 0.0139 Tc 3.767 0 Td (permeability. )Tj 0.149 0.149 0.141 rg 0.0123 Tc 5.831 0 Td (Relationship )Tj 0.22 0.22 0.216 rg -0.011 Tc 5.566 0 Td (to )Tj 0.149 0.149 0.141 rg 0.0041 Tc -25.262 -1.091 Td (airway )Tj 0.22 0.22 0.216 rg 0.0071 Tc 3.118 0 Td (reactivity. )Tj 0.149 0.149 0.141 rg /T1_2 1 Tf 0.05 Tc 9.0617 0 0 8.8 120.62 488.89 Tm (Am )Tj 0.22 0.22 0.216 rg 0.0444 Tc 8.8 0 0 8.8 136.39 488.89 Tm (Rev )Tj 0.0244 Tc 1.909 0 Td (Respir )Tj 0.149 0.149 0.141 rg -0.0018 Tc 3.056 0 Td (Dis, )Tj 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0008 Tc 2.084 0 Td (1984, )Tj -0.0141 Tc 2.727 0 Td (129, )Tj 0.0282 Tc 2.182 0 Td (143-148. )Tj 0.0107 Tc -21.382 -1.145 Td (19. )Tj 0.0268 Tc 1.769 0 Td (Chopra )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0169 Tc 8.8 0 0 8.8 99.6764 478.814 Tm (SK, )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0273 Tc 8.8 0 0 8.8 118.0068 478.814 Tm (Taplin )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0.006 Tc 8.8 0 0 8.8 146.3076 478.814 Tm (GV, )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0208 Tc 8.8 0 0 8.8 165.5268 478.814 Tm (Tashkin )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0079 Tc 8.8 0 0 8.8 200.1196 478.814 Tm (DP, )Tj EMC ET BT /T1_0 1 Tf 0.011 Tc 8.8 0 0 8.8 218.3532 478.814 Tm (Elam )Tj -0.0282 Tc 2.674 0 Td (D. )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 254.3012 478.814 Tm (-)Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0098 Tc 8.8 0 0 8.8 263.9548 478.814 Tm (Lung )Tj 0.22 0.22 0.216 rg 0.0156 Tc -23.95 -1.091 Td (clearance )Tj 0.05 Tc 9.4598 0 0 8.8 93.99 469.21 Tm (of )Tj 0.0141 Tc 8.8 0 0 8.8 107.88 469.21 Tm (soluble )Tj 0.0107 Tc 3.722 0 Td (radioaerosols )Tj 0.05 Tc 10.0163 0 0 8.8 194.78 469.21 Tm (of )Tj 0.0144 Tc 8.8 0 0 8.8 209.2 469.21 Tm (different )Tj 0.0196 Tc 4.261 0 Td (molecular )Tj 0.149 0.149 0.141 rg 0.01 Tc -21.981 -1.147 Td (weights )Tj 0.22 0.22 0.216 rg 0.0028 Tc 3.593 0 Td (in )Tj 0.0186 Tc 1.14 0 Td (systemic )Tj 0.0049 Tc 3.982 0 Td (sclerosis. )Tj /T1_2 1 Tf 0.0032 Tc 4.139 0 Td (Thorax, )Tj 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0144 Tc 3.641 0 Td (1979, )Tj 0.22 0.22 0.216 rg -0.0065 Tc 2.695 0 Td (34, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0447 Tc 8.8 0 0 8.8 236.524 459.1164 Tm (63-67. )Tj EMC /Suspect <>BDC 0.039 Tc -20.884 -1.09 Td (20. )Tj EMC ET BT /T1_0 1 Tf 0.0118 Tc 8.8 0 0 8.8 69.0776 449.5244 Tm (Rinderknecht )Tj -0.035 Tc 9.4291 0 0 9.9 120.91 449.53 Tm (JL, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0149 Tc 8.8 0 0 8.8 135.68 449.53 Tm (Shapiro )Tj EMC /Suspect <>BDC 0.149 0.149 0.141 rg 0.025 Tc 3.612 0 Td (L, )Tj EMC ET BT /T1_0 1 Tf 0.0181 Tc 8.8 0 0 8.8 178.9936 449.53 Tm (Krauthammer )Tj -0.035 Tc 8.7796 0 0 8.8 232.76 449.53 Tm (M, )Tj 0.0273 Tc 8.8 0 0 8.8 246.17 449.53 Tm (Taplin )Tj 0.22 0.22 0.216 rg 0.0249 Tc 3.107 0 Td (G, )Tj 0.0183 Tc -25.084 -1.2 Td (Wasserman )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.7287 0 0 8.8 99.8 438.97 Tm (K, )Tj EMC /Suspect <>BDC 0.149 0.149 0.141 rg 0.0142 Tc 8.8 0 0 8.8 112.79 438.97 Tm (Uszler )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf -0.0236 Tc 8.8 0 0 8.8 140.5892 438.97 Tm (JM, )Tj 0.149 0.149 0.141 rg 0.0048 Tc 2.073 0 Td (Effros )Tj -0.0014 Tc 3.056 0 Td (RM. )Tj 0.22 0.22 0.216 rg 0 Tc 2.284 0 Td (-)Tj 0.0093 Tc 1.045 0 Td (Accelerated )Tj 0.0187 Tc 5.338 0 Td (clear\255)Tj 0.0122 Tc -23.782 -1.091 Td (ance )Tj 0.306 0.31 0.302 rg 0.05 Tc 9.4598 0 0 8.8 75.27 429.37 Tm (of )Tj 0.22 0.22 0.216 rg 0.0247 Tc 8.8 0 0 8.8 88.68 429.37 Tm (small )Tj 0.0235 Tc 2.891 0 Td (solutes )Tj 0.0005 Tc 3.602 0 Td (from )Tj 0.0184 Tc 2.627 0 Td (the )Tj 0.0214 Tc 1.903 0 Td (lungs )Tj 0.05 Tc 8.8796 0 0 8.8 211.13 429.37 Tm (in )Tj 0.0104 Tc 8.8 0 0 8.8 224.09 429.37 Tm (interstitial )Tj 0.0127 Tc 4.855 0 Td (lung )Tj 0.0055 Tc -24.328 -1.147 Td (disease. )Tj /T1_2 1 Tf 0.05 Tc 9.0617 0 0 8.8 84.14 419.28 Tm (Am )Tj 0.0444 Tc 8.8 0 0 8.8 99.91 419.28 Tm (Rev )Tj 0.0354 Tc 1.855 0 Td (Respir )Tj 0.0164 Tc 3.11 0 Td (Dis, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0144 Tc 8.8 0 0 8.8 161.9412 419.28 Tm (1980, )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0041 Tc 8.8 0 0 8.8 185.9388 419.28 Tm (121, )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0282 Tc 8.8 0 0 8.8 205.1404 419.28 Tm (105-117. )Tj EMC ET BT /T1_0 1 Tf 0.039 Tc 8.8 0 0 8.8 52.2668 409.2128 Tm (21. )Tj 0.149 0.149 0.141 rg 0.0129 Tc 1.856 0 Td (Huchon )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0124 Tc 8.8 0 0 8.8 103.1132 409.2128 Tm (OJ, )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0022 Tc 8.8 0 0 8.8 122.3676 409.2128 Tm (Russel )Tj 0.0327 Tc 3.435 0 Td (JA, )Tj 0.0137 Tc 2.128 0 Td (Barritault )Tj 0.006 Tc 4.69 0 Td (LG, )Tj 0.22 0.22 0.216 rg 0.0081 Tc 2.4 0 Td (Lipavsky )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.763 0 0 8.8 273.58 409.21 Tm (A, )Tj EMC ET BT /T1_0 1 Tf 0.0134 Tc 8.8 0 0 8.8 52.76 399.12 Tm (Murray )Tj 0.0135 Tc 8.7 0 0 8.7 83.95 399.12 Tm (JF. )Tj 0.306 0.31 0.302 rg 0 Tc 1.705 0 Td (-)Tj 0.22 0.22 0.216 rg 0.0216 Tc 8.8 0 0 8.8 107.91 399.12 Tm (Chronic )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0245 Tc 8.8 0 0 8.8 141.9924 399.12 Tm (air )Tj EMC ET BT /T1_0 1 Tf -0.0171 Tc 8.8 0 0 8.8 155.9052 399.12 Tm (flow )Tj 0.0128 Tc 2.349 0 Td (limitation )Tj 0.0105 Tc 4.472 0 Td (does )Tj 0.0177 Tc 2.353 0 Td (not )Tj 0.0103 Tc 1.848 0 Td (increase )Tj 0.0145 Tc -22.793 -1.144 Td (respiratory )Tj 0.0077 Tc 5.173 0 Td (epithelial )Tj 0.0131 Tc 4.484 0 Td (permeability )Tj 0.0089 Tc 5.934 0 Td (assessed )Tj 0.149 0.149 0.141 rg 0.046 Tc 4.157 0 Td (by )Tj 0.22 0.22 0.216 rg 0.0099 Tc 1.734 0 Td (aerosolized )Tj 0.0103 Tc -21.494 -1.145 Td (solute, )Tj 0.0208 Tc 3.288 0 Td (but )Tj 0.306 0.31 0.302 rg 0.0213 Tc 1.84 0 Td (smoking )Tj 0.22 0.22 0.216 rg -0.0001 Tc 4.15 0 Td (does. )Tj /T1_2 1 Tf 0.05 Tc 9.0617 0 0 8.8 157.1 378.97 Tm (Am )Tj 0.0171 Tc 8.8 0 0 8.8 174.31 378.97 Tm (Rev )Tj 0.0244 Tc 2.073 0 Td (Respir )Tj 0.0164 Tc 3.274 0 Td (Dis, )Tj /T1_0 1 Tf 0.0008 Tc 2.302 0 Td (1984, )Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /T1_0 1 Tf -0.0141 Tc 8.8 0 0 8.8 266.578 378.97 Tm (130, )Tj EMC /Suspect <>BDC 0.22 0.22 0.216 rg 0.0436 Tc -24.407 -1.091 Td (457-460. )Tj EMC ET BT /T1_0 1 Tf 0.0117 Tc 8.8 0 0 8.8 52.2628 359.2756 Tm (22. )Tj 0.149 0.149 0.141 rg 0.0145 Tc 1.745 0 Td (Jefferies )Tj 0.22 0.22 0.216 rg 0.0028 Tc 4.094 0 Td (AL, )Tj 0.0171 Tc 2.174 0 Td (Coates )Tj 0.0249 Tc 3.382 0 Td (G, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0301 Tc 8.8 0 0 8.8 165.9764 359.2756 Tm (O'Brodovich )Tj EMC ET BT /T1_0 1 Tf -0.0336 Tc 8.8 0 0 8.8 219.3044 359.2756 Tm (H. )Tj ET BT /Suspect <>BDC 0.306 0.31 0.302 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 232.2052 359.2756 Tm (-)Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0128 Tc 8.8 0 0 8.8 242.3428 359.2756 Tm (Pulmonary )Tj 0.22 0.22 0.216 rg 0.0259 Tc -21.66 -1.144 Td (epithelial )Tj 0.0131 Tc 4.32 0 Td (permeability )Tj 0.05 Tc 8.8796 0 0 8.8 139.61 349.21 Tm (in )Tj 0.0137 Tc 8.8 0 0 8.8 150.71 349.21 Tm (hyaline-membrane )Tj 0.0055 Tc 8.174 0 Td (disease. )Tj /T1_2 1 Tf 0 Tc 9.6 0 0 9.6 254.49 349.21 Tm (N )Tj 0.0212 Tc 8.8 0 0 8.8 265.02 349.21 Tm (Engl )Tj 0.149 0.149 0.141 rg 0 Tc 9.6 0 0 9.6 51.46 339.61 Tm (J )Tj 0.0026 Tc 8.8 0 0 8.8 59.13 339.61 Tm (Med, )Tj 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0008 Tc 2.519 0 Td (1984, )Tj 0.029 Tc 2.641 0 Td (311, )Tj ET BT /Suspect <>BDC 0.306 0.31 0.302 rg /T1_0 1 Tf 0.0259 Tc 8.8 0 0 8.8 124.4964 339.61 Tm (1075-1)Tj 0.149 0.149 0.141 rg 0.0239 Tc 2.969 0 Td (080. )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0117 Tc 8.8 0 0 8.8 51.782 329.534 Tm (23. )Tj 0.0151 Tc 1.801 0 Td (Buxton-Thomas )Tj 0.05 Tc 8.961 0 0 8.8 129.56 329.53 Tm (M, )Tj 0.149 0.149 0.141 rg 0.0086 Tc 8.8 0 0 8.8 143.96 329.53 Tm (Higenbottam )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0292 Tc 8.8 0 0 8.8 193.8472 329.53 Tm (T, )Tj EMC ET BT /T1_0 1 Tf 0.028 Tc 8.8 0 0 8.8 205.3928 329.53 Tm (Barber )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 8.7402 0 0 8.8 233.72 329.53 Tm (R, )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0244 Tc 8.8 0 0 8.8 245.25 329.53 Tm (Wright )Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /T1_0 1 Tf -0.027 Tc 8.8 0 0 8.8 274.5188 329.53 Tm (P. )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.3979 0 0 8.8 51.25 319.93 Tm (-Clearance )Tj 0.22 0.22 0.216 rg 10.0163 0 0 8.8 98.78 319.93 Tm (of )Tj 0.0218 Tc 8.8 0 0 8.8 109.85 319.93 Tm (inhaled )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0001 Tc 6.4001 0 0 6.4001 139.61 322.33 Tm (99)Tj 0.0046 Tc 8.8 0 0 8.8 146.23 319.93 Tm ("'Tc-DTPA )Tj EMC ET BT /T1_0 1 Tf 0.0005 Tc 8.8 0 0 8.8 189.9836 319.93 Tm (from )Tj 0.149 0.149 0.141 rg 0.0097 Tc 2.356 0 Td (regions )Tj 0.22 0.22 0.216 rg 0.05 Tc 9.4598 0 0 8.8 240.39 319.93 Tm (of )Tj -0.0088 Tc 8.8 0 0 8.8 251.98 319.93 Tm (the )Tj 0.0127 Tc 1.576 0 Td (lung )Tj 0.0159 Tc -24.375 -1.147 Td (recently )Tj 0.0176 Tc 3.755 0 Td (affected )Tj 0.149 0.149 0.141 rg 0.046 Tc 3.775 0 Td (by )Tj 0.22 0.22 0.216 rg 0.0121 Tc 1.418 0 Td (pulmonary )Tj 0.0133 Tc 4.843 0 Td (embolus. )Tj 0.149 0.149 0.141 rg /T1_2 1 Tf 0.0451 Tc 4.109 0 Td (Bull )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_2 1 Tf -0.035 Tc 9.6535 0 0 9.8 228.07 309.84 Tm (Eur )Tj EMC /Suspect <>BDC 0.149 0.149 0.141 rg 0.0104 Tc 8.8 0 0 8.8 244.87 309.84 Tm (Physiopa\255)Tj EMC ET BT 0.22 0.22 0.216 rg /T1_2 1 Tf 0.0295 Tc 8.8 0 0 8.8 51.2612 299.764 Tm (thol )Tj 0.149 0.149 0.141 rg 0.0151 Tc 1.983 0 Td (Respir, )Tj 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0008 Tc 3.394 0 Td (1979, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0117 Tc 8.8 0 0 8.8 121.8724 299.764 Tm (22. )Tj EMC /Suspect <>BDC 0.0447 Tc 1.684 0 Td (63-67. )Tj EMC ET BT /T1_0 1 Tf 0.0117 Tc 8.8 0 0 8.8 51.314 290.1632 Tm (24. )Tj 0.149 0.149 0.141 rg 0.0315 Tc 1.801 0 Td (Mason )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0376 Tc 8.8 0 0 8.8 94.9532 290.1632 Tm (OR, )Tj EMC ET BT /T1_0 1 Tf 0.0048 Tc 8.8 0 0 8.8 113.7148 290.1632 Tm (Effros )Tj 0.149 0.149 0.141 rg -0.0014 Tc 2.947 0 Td (RM, )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0142 Tc 8.8 0 0 8.8 159.3604 290.1632 Tm (Uszler )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0125 Tc 8.7 0 0 8.7 186.19 290.16 Tm (JM, )Tj 0.0088 Tc 8.8 0 0 8.8 203.48 290.16 Tm (Mena )Tj 0.22 0.22 0.216 rg /T1_1 1 Tf 0.0283 Tc 9.1 0 0 9.1 227.27 290.16 Tm (I. )Tj 0.306 0.31 0.302 rg 0 Tc 0.915 0 Td (-)Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0125 Tc 8.8 0 0 8.8 243.68 290.16 Tm (Small )Tj EMC ET BT /T1_0 1 Tf 0.0178 Tc 8.8 0 0 8.8 267.7216 290.16 Tm (sol\255)Tj 0.0176 Tc -24.586 -1.144 Td (ute )Tj 0.0224 Tc 1.626 0 Td (clearance )Tj 0.0005 Tc 4.308 0 Td (from )Tj 0.0184 Tc 2.409 0 Td (the )Tj 0.0214 Tc 1.576 0 Td (lungs )Tj 0.05 Tc 9.4598 0 0 8.8 161.67 280.09 Tm (of )Tj 0.0095 Tc 8.8 0 0 8.8 172.81 280.09 Tm [(patients )-151(with )]TJ 0.149 0.149 0.141 rg 0.0107 Tc 5.77 0 Td (cardiogenic )Tj 0.22 0.22 0.216 rg -0.0069 Tc 5.182 0 Td (and )Tj 0.0426 Tc -24.809 -1.147 Td (non )Tj 0.0107 Tc 1.955 0 Td (cardiogenic )Tj 0.0121 Tc 5.139 0 Td (pulmonary )Tj 0.306 0.31 0.302 rg 0.0109 Tc 4.789 0 Td (edema. )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_2 1 Tf 0.0096 Tc 8.8 0 0 8.8 184.162 269.9964 Tm (Chest, )Tj EMC ET BT /T1_0 1 Tf 0.0008 Tc 8.8 0 0 8.8 210.914 269.9964 Tm (1985, )Tj -0.0074 Tc 2.635 0 Td (88, )Tj 0.0311 Tc 1.587 0 Td (327-334. )Tj 0.039 Tc -22.412 -1.09 Td (25. )Tj 0.149 0.149 0.141 rg 0.0358 Tc 1.747 0 Td (Braud)Tj 0.306 0.31 0.302 rg 0 Tc 2.612 0 Td (e )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf -0.0078 Tc 8.8 0 0 8.8 96.8132 260.4044 Tm (S, )Tj EMC ET BT /T1_0 1 Tf 0.0298 Tc 8.8 0 0 8.8 107.5756 260.4044 Tm (Nolop )Tj 0.0003 Tc 3.045 0 Td (KB, )Tj 0.0132 Tc 2.073 0 Td (Hughes )Tj 0.149 0.149 0.141 rg -0.0013 Tc 3.599 0 Td (JMB, )Tj 0.22 0.22 0.216 rg 0.0277 Tc 2.619 0 Td (Barnes )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0102 Tc 8.8 0 0 8.8 236.61 260.4044 Tm (PJ, )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 251.4908 260.4044 Tm (R)Tj 0.306 0.31 0.302 rg 0.0054 Tc 0.65 0 Td (oyston )Tj 0.149 0.149 0.141 rg -0.0282 Tc -23.395 -1.145 Td (D. )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 63.7516 250.3284 Tm (-)Tj EMC ET BT /T1_0 1 Tf 0.0111 Tc 8.8 0 0 8.8 72.886 250.3284 Tm (Comparison )Tj 0.05 Tc 9.4598 0 0 8.8 120.87 250.33 Tm (of )Tj 0.0127 Tc 8.8 0 0 8.8 132.89 250.33 Tm (lung )Tj 0.0163 Tc 2.297 0 Td (vascular )Tj -0.0069 Tc 3.919 0 Td (and )Tj 0.0138 Tc 1.909 0 Td (epithelial )Tj 0.0173 Tc 4.266 0 Td (permeabil\255)Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0007 Tc 8.8 0 0 8.8 51.2876 240.254 Tm (ity )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.013 Tc 8.8 0 0 8.8 63.766 240.254 Tm (indices )Tj 0.0028 Tc 3.327 0 Td (in )Tj 0.22 0.22 0.216 rg 0.0457 Tc 1.151 0 Td (the )Tj 0.0353 Tc 1.628 0 Td (adult )Tj 0.009 Tc 2.409 0 Td (respiratory )Tj 0.0095 Tc 4.847 0 Td (distress )Tj 0.0178 Tc 3.432 0 Td (syndrome. )Tj /T1_2 1 Tf 0.05 Tc 9.0617 0 0 8.8 252.62 240.25 Tm (Am )Tj 0.0444 Tc 8.8 0 0 8.8 267.91 240.25 Tm (Rev )Tj 0.0244 Tc -24.655 -1.091 Td (Respir )Tj -0.0018 Tc 3.056 0 Td (Dis, )Tj /T1_0 1 Tf 0.0008 Tc 2.139 0 Td (1986, )Tj 0.0223 Tc 2.673 0 Td (133, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0199 Tc 8.8 0 0 8.8 139.8612 230.6492 Tm (1002-1005. )Tj EMC ET BT /T1_0 1 Tf 0.0117 Tc 8.8 0 0 8.8 50.8316 221.0484 Tm (26. )Tj 0.0298 Tc 1.756 0 Td (Nolop )Tj 0.0003 Tc 3.045 0 Td (KB, )Tj 0.149 0.149 0.141 rg 0.0273 Tc 2.127 0 Td (Braude )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf -0.0078 Tc 8.8 0 0 8.8 141.9204 221.0484 Tm (S, )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0178 Tc 8.8 0 0 8.8 152.6036 221.0484 Tm (Royston )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0264 Tc 8.8 0 0 8.8 186.686 221.0484 Tm (D, )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0281 Tc 8.8 0 0 8.8 198.6892 221.0484 Tm (Maxwell )Tj 0.149 0.149 0.141 rg -0.0191 Tc 4.2 0 Td (DL, )Tj 0.0132 Tc 2.018 0 Td (Hughes )Tj -0.0013 Tc -23.019 -1.145 Td (JMB. )Tj 0.22 0.22 0.216 rg 0 Tc 2.612 0 Td (-)Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0134 Tc 8.8 0 0 8.8 82.5292 210.9724 Tm (Positive-end )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0126 Tc 8.8 0 0 8.8 130.9556 210.9724 Tm (expiratory )Tj 0.0165 Tc 4.593 0 Td (pressure )Tj 0.015 Tc 3.864 0 Td (increases )Tj 0.0121 Tc 4.155 0 Td (pulmonary )Tj 0.0156 Tc -21.72 -1.091 Td (clearance )Tj 0.05 Tc 9.4598 0 0 8.8 88.71 201.37 Tm (of )Tj 0.0127 Tc 8.8 0 0 8.8 100.25 201.37 Tm (inhaled )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0154 Tc 6.3001 0 0 6.3001 130.49 203.76 Tm (99)Tj -0.0037 Tc 8.8 0 0 8.8 137.11 201.37 Tm ("'1'c-DTPA )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.8796 0 0 8.8 181.37 201.37 Tm (in )Tj 0.013 Tc 8.8 0 0 8.8 192.47 201.37 Tm (non-smokers )Tj 0.0208 Tc 5.784 0 Td (but )Tj 0.149 0.149 0.141 rg -0.0149 Tc 1.689 0 Td (no)Tj 0.306 0.31 0.302 rg 0 Tc 1.09 0 Td (t )Tj 0.22 0.22 0.216 rg 0.05 Tc 8.8796 0 0 8.7 274.01 201.37 Tm (in )Tj 0.0197 Tc 8.8 0 0 8.8 50.39 191.29 Tm (healthy )Tj 0.306 0.31 0.302 rg 0.0141 Tc 3.642 0 Td (smokers. )Tj 0.149 0.149 0.141 rg /T1_2 1 Tf 0.0269 Tc 4.331 0 Td (Bull )Tj 0.22 0.22 0.216 rg 0.0076 Tc 2.344 0 Td (Eur )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0205 Tc 8.8 0 0 8.8 159.4308 191.29 Tm (Physiopathol )Tj EMC ET BT /T1_2 1 Tf 0.0151 Tc 8.8 0 0 8.8 212.7148 191.29 Tm (Respir, )Tj /T1_0 1 Tf 0.0008 Tc 3.612 0 Td (1987, )Tj 0.039 Tc 2.81 0 Td (23, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0466 Tc 8.8 0 0 8.8 50.2756 181.214 Tm (57-60. )Tj EMC ET BT /T1_0 1 Tf 0.0117 Tc 8.8 0 0 8.8 50.346 171.6132 Tm (27. )Tj 0.149 0.149 0.141 rg 0.0251 Tc 1.741 0 Td (Giuntini )Tj 0.22 0.22 0.216 rg 0.0329 Tc 4.255 0 Td (C, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0083 Tc 8.8 0 0 8.8 118.5196 171.6132 Tm (Pistolesi )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.7796 0 0 8.8 155.96 171.61 Tm (M, )Tj 0.149 0.149 0.141 rg 0.0122 Tc 8.8 0 0 8.8 172.76 171.61 Tm (Begliomini )Tj 0.22 0.22 0.216 rg -0.029 Tc 5.399 0 Td (E, )Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0085 Tc 8.8 0 0 8.8 235.1608 171.61 Tm (Pollastri )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf -0.035 Tc 8.763 0 0 8.8 271.66 171.61 Tm (A, )Tj 0.0297 Tc 8.8 0 0 8.8 49.88 161.52 Tm (Ballestra )Tj -0.0003 Tc 4.475 0 Td (AM, )Tj 0.149 0.149 0.141 rg 0.0255 Tc 2.561 0 Td (Maseri )Tj 0.22 0.22 0.216 rg -0.035 Tc 8.763 0 0 8.8 143.5 161.52 Tm (A. )Tj 0 Tc 8.8 0 0 8.8 157.82 161.52 Tm (-)Tj 0.149 0.149 0.141 rg 0.023 Tc 1.31 0 Td (Chest )Tj 0.22 0.22 0.216 rg 0.0187 Tc 3.009 0 Td (X-ray )Tj /T1_2 1 Tf 0.0144 Tc 3.159 0 Td (versus )Tj /T1_0 1 Tf 0.0092 Tc 3.269 0 Td (dilution )Tj 0.0124 Tc -22.957 -1.145 Td (method )Tj 0.0028 Tc 3.649 0 Td (in )Tj 0.0184 Tc 1.369 0 Td (the )Tj 0.011 Tc 1.847 0 Td (assessment )Tj 0.05 Tc 9.4598 0 0 8.8 155.43 151.44 Tm (of )Tj 0.0121 Tc 8.8 0 0 8.8 168.01 151.44 Tm (pulmonary )Tj 0.0353 Tc 5.007 0 Td (edema )Tj 0.0028 Tc 3.275 0 Td (in )Tj 0.0095 Tc 1.318 0 Td (patients )Tj -22.966 -1.09 Td (with )Tj 0.0253 Tc 2.227 0 Td (coronary )Tj 0.0202 Tc 4.209 0 Td (heart )Tj 0.0107 Tc 2.556 0 Td (diseases. )Tj 0.0183 Tc 4.1 0 Td (/n: )Tj 0.0134 Tc 1.626 0 Td (Cardiac )Tj 0.149 0.149 0.141 rg -0.0006 Tc 3.714 0 Td (Lung. )Tj 0.22 0.22 0.216 rg -0.0217 Tc 2.886 0 Td (C. )Tj 0.0096 Tc 1.418 0 Td (Giuntini )Tj -0.0152 Tc -22.745 -1.147 Td (and, )Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 71.958 131.7544 Tm (P)Tj 0.306 0.31 0.302 rg 0.584 0 Td (. )Tj EMC /Suspect <>BDC 0.22 0.22 0.216 rg 0.0089 Tc 0.998 0 Td (Panuccio )Tj EMC ET BT /T1_0 1 Tf 0.0065 Tc 8.8 0 0 8.8 125.1892 131.7544 Tm (eds, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0166 Tc 8.8 0 0 8.8 145.878 131.7544 Tm (Piccin )Tj EMC ET BT /T1_0 1 Tf 0.011 Tc 8.8 0 0 8.8 174.6804 131.7544 Tm (Medical )Tj 0.0106 Tc 4.145 0 Td (Books, )Tj 0.0008 Tc 3.625 0 Td (1979, )Tj 0.034 Tc 2.926 0 Td (pp. )Tj 0.0363 Tc -24.88 -1.145 Td (251-259. )Tj 0.0117 Tc 29.018 70.801 Td (28. )Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /T1_0 1 Tf -0.035 Tc 8.5656 0 0 8.8 321.56 744.73 Tm (RUhle )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf -0.0277 Tc 8.8 0 0 8.8 347 744.73 Tm (KH, )Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0236 Tc 8.8 0 0 8.8 366.2016 744.73 Tm (K6hler )Tj EMC ET BT /T1_0 1 Tf -0.0282 Tc 8.8 0 0 8.8 395.4792 744.73 Tm (D, )Tj 0.22 0.22 0.216 rg 0.0166 Tc 1.473 0 Td (Fisher )Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /T1_0 1 Tf -0.035 Tc 8.8613 0 0 9.6 435.31 744.73 Tm (J, )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0105 Tc 8.8 0 0 8.8 445.4 744.73 Tm (Matthys )Tj 0.149 0.149 0.141 rg 0.021 Tc 3.818 0 Td (H. )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 491.8992 744.73 Tm (-)Tj EMC ET BT /T1_0 1 Tf 0.008 Tc 8.8 0 0 8.8 501.0776 744.73 Tm (Measure\255)Tj 0.0046 Tc -22.252 -1.145 Td (ments )Tj 0.05 Tc 9.4598 0 0 8.8 329.19 734.65 Tm (of )Tj 0.0089 Tc 8.8 0 0 8.8 339.34 734.65 Tm (mucociliary )Tj 0.0088 Tc 5.119 0 Td (clearance )Tj 0.0095 Tc 4.155 0 Td (with )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 6.1271 0 0 6.4001 439.61 737.53 Tm (99)Tj -0.0016 Tc 8.8 0 0 8.8 445.75 734.65 Tm ("'Tc-tagged )Tj EMC ET BT /T1_0 1 Tf -0.0034 Tc 8.8 0 0 8.8 489.0284 734.65 Tm (erythrocytes. )Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /T1_2 1 Tf 0.003 Tc 8.8 0 0 8.8 305.346 725.0492 Tm (Prog )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_2 1 Tf 0.0135 Tc 8.8 0 0 8.8 326.466 725.0492 Tm (Respir )Tj 0.0006 Tc 3.055 0 Td (Res, )Tj /T1_0 1 Tf 0.0008 Tc 2.14 0 Td (1979, )Tj -0.0166 Tc 2.727 0 Td (11, )Tj 0.036 Tc 1.636 0 Td (117-126. )Tj 0.149 0.149 0.141 rg 0.0117 Tc -11.972 -1.092 Td (29. )Tj 0.22 0.22 0.216 rg 0.001 Tc 1.856 0 Td (Dottorini )Tj 0.017 Tc 4.145 0 Td (M, )Tj 0.149 0.149 0.141 rg 0.0208 Tc 1.578 0 Td (Todisco )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0292 Tc 8.8 0 0 8.8 405.0412 715.4396 Tm (T, )Tj EMC ET BT /T1_0 1 Tf 0.0379 Tc 8.8 0 0 8.8 417.018 715.4396 Tm (Grassi )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf -0.035 Tc 8.7706 0 0 8.8 444.94 715.44 Tm (V. )Tj EMC /Suspect <>BDC 0.306 0.31 0.302 rg 0 Tc 8.8 0 0 8.8 457.34 715.44 Tm (-)Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0066 Tc 8.8 0 0 8.8 466.5096 715.44 Tm (Epithelial )Tj 0.22 0.22 0.216 rg 0.0107 Tc 4.425 0 Td (permea\255)Tj -0.0051 Tc -22.745 -1.145 Td (bility )Tj 0.05 Tc 8.8796 0 0 8.8 326.81 705.36 Tm (in )Tj 0.0036 Tc 8.8 0 0 8.8 336.84 705.36 Tm (smokers )Tj -0.0069 Tc 3.767 0 Td (and )Tj 0.149 0.149 0.141 rg 0.0028 Tc 1.802 0 Td (in )Tj 0.22 0.22 0.216 rg 0.0005 Tc 1.145 0 Td (interstitial )Tj 0.0127 Tc 4.418 0 Td (lung )Tj -0.0023 Tc 2.181 0 Td (disease. )Tj 0.149 0.149 0.141 rg 0.0005 Tc 3.552 0 Td (Abstract )Tj 0.22 0.22 0.216 rg -0.0177 Tc 3.7 0 Td (from )Tj 0.0184 Tc -24.155 -1.091 Td (the )Tj 0.0187 Tc 1.631 0 Td (lntemational )Tj 0.0141 Tc 5.608 0 Td (Symposium )Tj 0.05 Tc 8.8578 0 0 8.8 415.12 695.76 Tm (on )Tj -0.0088 Tc 8.8 0 0 8.8 428.14 695.76 Tm (the )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0205 Tc 8.8 0 0 8.8 442.396 695.76 Tm (Surfactant )Tj EMC /Suspect <>BDC 0.0185 Tc 4.582 0 Td (System )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.4598 0 0 8.8 512.55 695.76 Tm (of )Tj -0.0088 Tc 8.8 0 0 8.8 524.14 695.76 Tm (the )Tj -0.0006 Tc -24.876 -1.09 Td (Lung. )Tj -0.035 Tc 8.2775 0 0 8.8 330.2 686.17 Tm (F. )Tj 0.0002 Tc 8.8 0 0 8.8 340.75 686.17 Tm (Lorenzini )Tj 0.0165 Tc 4.305 0 Td (ed., )Tj 0.0098 Tc 1.86 0 Td (Rome, )Tj 0.0144 Tc 3.134 0 Td (1983, )Tj 0.149 0.149 0.141 rg 0 Tc 2.599 0 Td (p)Tj 0.306 0.31 0.302 rg 0.578 0 Td (. )Tj 0.22 0.22 0.216 rg 0.0146 Tc 0.61 0 Td (76. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0207 Tc 8.8 0 0 8.8 304.6964 676.094 Tm (30. )Tj EMC ET BT /T1_0 1 Tf 0.0154 Tc 8.8 0 0 8.8 321.0732 676.094 Tm (Dusser )Tj -0.035 Tc 9.0393 0 0 9.2 349.88 676.09 Tm (DJ, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0192 Tc 8.8 0 0 8.8 364.76 676.09 Tm (Minty )Tj EMC ET BT /T1_0 1 Tf 0.01 Tc 8.8 0 0 8.8 390.68 676.09 Tm (BD, )Tj 0.0144 Tc 2.067 0 Td (Collignon )Tj 0.0334 Tc 4.478 0 Td (MAG, )Tj 0.0196 Tc 3.109 0 Td (Hinge )Tj -0.0282 Tc 2.891 0 Td (D. )Tj 0.0182 Tc 1.364 0 Td (Barri\255)Tj 0.0071 Tc -23.616 -1.092 Td (tault )Tj 0.006 Tc 2.397 0 Td (LG. )Tj 0.002 Tc 2.237 0 Td (Huchon )Tj ET BT /Suspect <>BDC 0.306 0.31 0.302 rg /T1_0 1 Tf -0.0148 Tc 8.8 0 0 8.8 379.108 666.4804 Tm (OJ. )Tj EMC /Suspect <>BDC 0.416 g 0 Tc 1.908 0 Td (-)Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf -0.0005 Tc 8.8 0 0 8.8 406.52 666.4804 Tm (Regional )Tj 0.0145 Tc 4.203 0 Td (respiratory )Tj 0.0088 Tc 5.064 0 Td (clearance )Tj 0.05 Tc 9.4598 0 0 8.8 526.95 666.48 Tm (of )Tj 0.0045 Tc 8.8 0 0 8.8 305.19 656.89 Tm (aerosolized )Tj ET BT /Suspect <>BDC 0.306 0.31 0.302 rg /T1_0 1 Tf -0.0151 Tc 6 0 0 6 348.89 659.29 Tm (99)Tj 0.005 Tc 8.8 0 0 8.8 355.1 656.89 Tm ('"Tc-DTP )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf -0.035 Tc 8.5161 0 0 8.8 389.27 656.89 Tm (A: )Tj 0.306 0.31 0.302 rg 0.0203 Tc 8.8 0 0 8.8 401.29 656.89 Tm (posture )Tj 0.0204 Tc 3.37 0 Td (and )Tj 0.22 0.22 0.216 rg 0.0213 Tc 1.797 0 Td (smoking )Tj 0.0077 Tc 3.931 0 Td (effects. )Tj /T1_3 1 Tf 0 Tc 8.6 0 0 8.6 509.68 656.89 Tm (J )Tj /T1_2 1 Tf 0.0453 Tc 8.8 0 0 8.8 517.09 656.89 Tm (Appl )Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /T1_2 1 Tf 0.0023 Tc 8.8 0 0 8.8 304.8692 646.7964 Tm (Physiol, )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0008 Tc 8.8 0 0 8.8 337.6228 646.7964 Tm (1986, )Tj ET BT /Suspect <>BDC 0.306 0.31 0.302 rg /T1_0 1 Tf 0.0126 Tc 8.8 0 0 8.8 360.8548 646.7964 Tm (60\(6\), )Tj EMC /Suspect <>BDC 0.0323 Tc 2.843 0 Td (2000-2006. )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0207 Tc 8.8 0 0 8.8 304.702 636.7292 Tm (31. )Tj 0.0061 Tc 1.864 0 Td (Ashbaugh )Tj 0.0067 Tc 4.689 0 Td (DG, )Tj 0.0303 Tc 2.236 0 Td (Bigelow )Tj 0.149 0.149 0.141 rg 0.0075 Tc 4.2 0 Td (DB, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0088 Tc 8.8 0 0 8.8 438.682 636.7292 Tm (Petty )Tj EMC /Suspect <>BDC 0.22 0.22 0.216 rg /T1_1 1 Tf 0.0051 Tc 9 0 0 9 462.18 636.73 Tm (TL, )Tj EMC ET BT /T1_0 1 Tf 0.026 Tc 8.8 0 0 8.8 480.91 636.73 Tm (Levine )Tj 0.149 0.149 0.141 rg 0.05 Tc 9.1997 0 0 8.8 510.68 636.73 Tm (BE)Tj 0.306 0.31 0.302 rg 0 Tc 8.8 0 0 8.8 523.02 636.73 Tm [(. )-273(-)]TJ 0.22 0.22 0.216 rg 0.0052 Tc -24.8 -1.092 Td (Acute )Tj 0.149 0.149 0.141 rg 0.0087 Tc 2.783 0 Td (resp)Tj 0.306 0.31 0.302 rg 0.0043 Tc 1.63 0 Td (iratory )Tj 0.22 0.22 0.216 rg 0.0017 Tc 3.108 0 Td (distress )Tj -0.035 Tc 8.5969 0 0 8.8 401.21 627.12 Tm (in )Tj -0.0011 Tc 8.8 0 0 8.8 411.27 627.12 Tm (adults. )Tj /T1_2 1 Tf 0.0052 Tc 2.966 0 Td (Lancet, )Tj /T1_0 1 Tf 0.0008 Tc 3.501 0 Td (1967, )Tj /T1_1 1 Tf 0.0142 Tc 2.633 0 Td (ii, )Tj /T1_0 1 Tf 0.0311 Tc 1.099 0 Td (319-323. )Tj 0.0207 Tc -22.309 -1.144 Td (32. )Tj 0.0137 Tc 1.807 0 Td (Fein )Tj -0.0003 Tc 2.293 0 Td (AM, )Tj 0.01 Tc 2.342 0 Td (Lippman )Tj 0.017 Tc 4.147 0 Td (M, )Tj 0.0188 Tc 1.636 0 Td (Holzman )Tj 0.149 0.149 0.141 rg 0.021 Tc 4.2 0 Td (H. )Tj 0.22 0.22 0.216 rg 0.0169 Tc 1.472 0 Td (Eliraz )Tj 0.149 0.149 0.141 rg -0.035 Tc 8.763 0 0 8.8 488.14 617.05 Tm (A, )Tj 0.22 0.22 0.216 rg 0.0083 Tc 8.8 0 0 8.8 500.55 617.05 Tm (Goldberg )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0169 Tc 8.8 0 0 8.8 304.6444 606.974 Tm (SK. )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 322.4644 606.974 Tm (-)Tj 0.149 0.149 0.141 rg 0.0499 Tc 0.876 0 Td (The )Tj 0.22 0.22 0.216 rg 0.0277 Tc 2.025 0 Td (risk )Tj 0.0018 Tc 2.008 0 Td (factors, )Tj 0.149 0.149 0.141 rg 0.0028 Tc 3.494 0 Td (in)Tj 0.306 0.31 0.302 rg 0 Tc 0.761 0 Td (c)Tj 0.149 0.149 0.141 rg 0.0275 Tc 0.439 0 Td (idence )Tj 0.22 0.22 0.216 rg -0.0069 Tc 3.161 0 Td (and )Tj 0.0197 Tc 1.866 0 Td (prognosis )Tj 0.05 Tc 9.4598 0 0 8.8 490.47 606.97 Tm (of )Tj -0.0088 Tc 8.8 0 0 8.8 502.06 606.97 Tm (the )Tj 0.0081 Tc 1.628 0 Td (adult )Tj 0.0145 Tc -24.1 -1.092 Td (respiratory )Tj 0.0095 Tc 5.119 0 Td (distress )Tj 0.0171 Tc 3.759 0 Td (syndrome )Tj 0.0096 Tc 4.693 0 Td (following )Tj 0.0088 Tc 4.689 0 Td (septicemia. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0013 Tc 8.8 0 0 8.8 511.5024 597.3604 Tm (Chest, )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0008 Tc 8.8 0 0 8.8 304.9752 587.7596 Tm (1983, )Tj 0.22 0.22 0.216 rg 0.0198 Tc 2.635 0 Td (83, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0428 Tc 8.8 0 0 8.8 342.6744 587.7596 Tm (40-42. )Tj EMC ET BT /T1_0 1 Tf 0.0207 Tc 8.8 0 0 8.8 304.6936 577.2084 Tm (33. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0123 Tc 8.8 0 0 8.8 320.5952 577.2084 Tm (Pepe )Tj EMC /Suspect <>BDC 0.0088 Tc 2.673 0 Td (PE, )Tj EMC /Suspect <>BDC 0.0156 Tc 2.127 0 Td (Potkin )Tj EMC ET BT /T1_0 1 Tf 0.0018 Tc 8.8 0 0 8.8 392.5968 577.2084 Tm (RT, )Tj 0.149 0.149 0.141 rg 0.0085 Tc 2.236 0 Td (Holtrnan)Tj 0.306 0.31 0.302 rg 0.0096 Tc 3.648 0 Td (-Revs )Tj 0.22 0.22 0.216 rg 0.0264 Tc 3.061 0 Td (D. )Tj 0.149 0.149 0.141 rg 0.0128 Tc 1.691 0 Td (Hudson )Tj 0.22 0.22 0.216 rg 0.006 Tc 3.817 0 Td (LD. )Tj 0.0135 Tc -24.441 -1.036 Td (Carrico )Tj -0.0144 Tc 3.491 0 Td (CJ. )Tj 0.149 0.149 0.141 rg 0 Tc 1.69 0 Td (-)Tj 0.22 0.22 0.216 rg 0.0192 Tc 0.928 0 Td (Clinical )Tj 0.0177 Tc 3.666 0 Td (predictors )Tj 0.05 Tc 9.4598 0 0 8.8 430.47 568.09 Tm (of )Tj 0.0184 Tc 8.8 0 0 8.8 442.06 568.09 Tm (the )Tj 0.0081 Tc 1.683 0 Td (adult )Tj 0.149 0.149 0.141 rg 0.009 Tc 2.409 0 Td (respiratory )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf -0.0058 Tc 8.8 0 0 8.8 520.7232 568.09 Tm (dis\255)Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0065 Tc 8.8 0 0 8.8 304.78 557.9964 Tm (tress )Tj 0.22 0.22 0.216 rg 0.011 Tc 2.225 0 Td (syndrome. )Tj /T1_2 1 Tf 0.05 Tc 9.4102 0 0 8.8 364.94 558 Tm (Am )Tj 0 Tc 9.6 0 0 9.6 380.26 558 Tm (J )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0217 Tc 8.8 0 0 8.8 387.83 558 Tm (Surg, )Tj EMC ET BT /T1_0 1 Tf 0.0008 Tc 8.8 0 0 8.8 411.5372 558 Tm (1982, )Tj 0.0041 Tc 2.673 0 Td (144. )Tj 0.149 0.149 0.141 rg 0.0282 Tc 2.236 0 Td (124-134. )Tj 0.22 0.22 0.216 rg 0.048 Tc -17.105 -1.145 Td (34. )Tj 0.149 0.149 0.141 rg 0.0192 Tc 1.807 0 Td (Minty )Tj 0.22 0.22 0.216 rg 0.0373 Tc 2.891 0 Td (BD. )Tj 0.149 0.149 0.141 rg 0.0141 Tc 2.072 0 Td (Jordan )Tj 0.22 0.22 0.216 rg 0.0329 Tc 3.159 0 Td (C, )Tj 0.149 0.149 0.141 rg 0.0195 Tc 1.314 0 Td (Jones )Tj 0.0327 Tc 2.673 0 Td (JG. )Tj 0.22 0.22 0.216 rg 0 Tc 1.794 0 Td (-)Tj 0.149 0.149 0.141 rg 0.0177 Tc 0.934 0 Td (Rapid )Tj 0.22 0.22 0.216 rg 0.0144 Tc 2.888 0 Td (improvement )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.4716 0 0 8.8 526.96 547.92 Tm (in )Tj EMC ET BT /T1_0 1 Tf 0.008 Tc 8.8 0 0 8.8 304.71 538.33 Tm (abnormal )Tj 0.0121 Tc 4.484 0 Td (pulmonary )Tj 0.0138 Tc 5.116 0 Td (epithelial )Tj 0.149 0.149 0.141 rg 0.018 Tc 4.484 0 Td (permeability )Tj 0.22 0.22 0.216 rg 0.0092 Tc 5.989 0 Td (after )Tj 0 Tc 2.506 0 Td (s)Tj 0.416 g 0.33 0 Td (')Tj 0.22 0.22 0.216 rg -0.0086 Tc 0.118 0 Td (topping )Tj 0.0091 Tc -23.081 -1.147 Td (cigarettes. )Tj /T1_2 1 Tf 0.05 Tc 9.1463 0 0 8.8 344.23 528.24 Tm (Br )Tj -0.0075 Tc 8.8 0 0 8.8 357.21 528.24 Tm (Med )Tj /T1_3 1 Tf -0.0261 Tc 8.3 0 0 8.3 375.76 528.24 Tm (J, )Tj /T1_0 1 Tf 0.0008 Tc 8.8 0 0 8.8 386.1 528.24 Tm (1981, )Tj 0.023 Tc 2.647 0 Td (282, )Tj 0.026 Tc 2.263 0 Td (1183-1186. )Tj 0.0207 Tc -14.214 -1.144 Td (35. )Tj 0.149 0.149 0.141 rg 0.0154 Tc 1.861 0 Td (Fowler )Tj 0.22 0.22 0.216 rg 0.0014 Tc 3.33 0 Td (AA, )Tj 0.149 0.149 0.141 rg 0.0226 Tc 2.125 0 Td (Hamman )Tj 0.0288 Tc 4.2 0 Td (RF, )Tj 0.22 0.22 0.216 rg 0.028 Tc 1.958 0 Td (Good )Tj 0.149 0.149 0.141 rg 0.0381 Tc 2.731 0 Td (IT. )Tj 0.306 0.31 0.302 rg 0 Tc 1.741 0 Td (-)Tj 0.22 0.22 0.216 rg 0.0188 Tc 0.991 0 Td (Adult )Tj 0.0036 Tc 2.783 0 Td (respiratory )Tj 0.0095 Tc -21.717 -1.092 Td (distress )Tj 0.0076 Tc 3.705 0 Td (syndrome: )Tj 0.0277 Tc 4.867 0 Td (risk )Tj -0.0087 Tc 2.236 0 Td (with )Tj 0.0246 Tc 2.391 0 Td (common )Tj 0.0133 Tc 4.157 0 Td (predispositions. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.05 Tc 9.0076 0 0 8.8 519.02 508.56 Tm (Ann )Tj EMC ET BT /T1_2 1 Tf 0.018 Tc 8.8 0 0 8.8 303.93 498.49 Tm (Intern )Tj 0.0026 Tc 2.891 0 Td (Med, )Tj /T1_0 1 Tf 0.0008 Tc 2.519 0 Td (1983, )Tj 0.0147 Tc 2.641 0 Td (98, )Tj 0.0307 Tc 1.689 0 Td (593-597. )Tj 0.0207 Tc -9.707 -1.091 Td (36. )Tj 0.0154 Tc 1.807 0 Td (Fowler )Tj -0.0259 Tc 3.275 0 Td (AA, )Tj 0.149 0.149 0.141 rg 0.0116 Tc 2.07 0 Td (Hamman )Tj 0.0348 Tc 4.091 0 Td (RF)Tj 0.306 0.31 0.302 rg 0 Tc 1.243 0 Td (, )Tj 0.22 0.22 0.216 rg 0.0208 Tc 0.612 0 Td (Zerbe )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.006 Tc 8.8 0 0 8.8 443.9028 488.8892 Tm (GO, )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0156 Tc 8.8 0 0 8.8 462.6732 488.8892 Tm (Benson )Tj -0.0019 Tc 3.436 0 Td (KW, )Tj -0.0108 Tc 2.291 0 Td (Hy)Tj 0.306 0.31 0.302 rg 0.0001 Tc 1.194 0 Td (ers )Tj 0.22 0.22 0.216 rg 0.0337 Tc -24.98 -1.145 Td (TM. )Tj 0 Tc 2.342 0 Td (-)Tj 0.0052 Tc 1.1 0 Td (Adult )Tj 0.0145 Tc 2.783 0 Td (respiratory )Tj 0.0095 Tc 5.01 0 Td (distress )Tj 0.0178 Tc 3.595 0 Td (syndrome. )Tj 0.0135 Tc 4.864 0 Td (Prognosis )Tj 0.0092 Tc 4.631 0 Td (after )Tj 0.149 0.149 0.141 rg 0.0068 Tc 8.7 0 0 8.7 304.24 469.21 Tm (onset. )Tj 0.22 0.22 0.216 rg /T1_2 1 Tf 0.05 Tc 9.0617 0 0 8.8 328.46 469.21 Tm (Am )Tj 0.149 0.149 0.141 rg 0.0444 Tc 8.8 0 0 8.8 344.23 469.21 Tm (Rev )Tj 0.0244 Tc 1.909 0 Td (Respir )Tj -0.0018 Tc 3.056 0 Td (Dis, )Tj /T1_0 1 Tf 0.0008 Tc 2.139 0 Td (1985, )Tj 0.22 0.22 0.216 rg 0.0041 Tc 2.673 0 Td (132, )Tj 0.149 0.149 0.141 rg 0.0358 Tc 2.157 0 Td (472-478. )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_2 1 Tf 0.0129 Tc 8.8 0 0 8.8 303.9172 445.6876 Tm (Permeabilit)Tj 0.416 g 0 Tc 4.838 0 Td (e )Tj EMC /Suspect <>BDC 0.306 0.31 0.302 rg 0.0163 Tc 1.145 0 Td (epitheliale )Tj EMC ET BT /T1_2 1 Tf 0.0185 Tc 8.8 0 0 8.8 400.6292 445.6876 Tm (pulmonaire )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_2 1 Tf 0.0376 Tc 8.8 0 0 8.8 448.2812 445.6876 Tm (dans )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_2 1 Tf -0.0069 Tc 8.8 0 0 8.8 472.2348 445.6876 Tm (le )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_2 1 Tf 0.0144 Tc 8.8 0 0 8.8 484.3612 445.6876 Tm (syndrome )Tj EMC /Suspect <>BDC 0.0452 Tc 8.6 0 0 8.6 525.08 445.69 Tm (de )Tj EMC ET BT 0.306 0.31 0.302 rg /T1_2 1 Tf 0.0369 Tc 8.8 0 0 8.8 303.79 436.56 Tm (dltresse )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_2 1 Tf 0.0099 Tc 8.8 0 0 8.8 340.266 436.56 Tm (respira)Tj 0 g 0 Tc 2.888 0 Td (.)Tj 0.306 0.31 0.302 rg 0.0209 Tc 0.052 0 Td (toire )Tj EMC /Suspect <>BDC 0.0472 Tc 2.677 0 Td (ai1ue )Tj EMC ET BT /T1_2 1 Tf 0.05 Tc 8.8825 0 0 8.8 416.56 436.56 Tm (et )Tj 0.0376 Tc 8.8 0 0 8.8 429.55 436.56 Tm (dans )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_2 1 Tf 0.009 Tc 8.8 0 0 8.8 453.9788 436.56 Tm (l'oedeme )Tj EMC /Suspect <>BDC 0.0185 Tc 4.3 0 Td (pulmonaire )Tj EMC ET BT 0.416 g /T1_2 1 Tf 0 Tc 8.8 0 0 8.8 303.7716 427.9272 Tm (c)Tj 0.306 0.31 0.302 rg 0.0271 Tc 0.492 0 Td (ardiogenique)Tj 0.416 g 0 Tc 5.67 0 Td (. )Tj 0.306 0.31 0.302 rg 0.97 0 Td (T)Tj 0.506 0.51 0.494 rg 0.666 0 Td (. )Tj ET BT /Suspect <>BDC 0.306 0.31 0.302 rg /T1_2 1 Tf -0.0064 Tc 8.8 0 0 8.8 380.93 427.9272 Tm (Tod1sco, )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_2 1 Tf 0 Tc 8.8 0 0 8.8 420.0812 427.9272 Tm (M)Tj 0.506 0.51 0.494 rg 0.908 0 Td (. )Tj 0.22 0.22 0.216 rg 1.055 0 Td (D)Tj 0.416 g 0.747 0 Td (o)Tj 0.22 0.22 0.216 rg 0.0214 Tc 0.542 0 Td (ttorini, )Tj /T1_3 1 Tf -0.035 Tc 8.9982 0 0 9.4 481.32 427.93 Tm (F. )Tj /T1_2 1 Tf 0.0194 Tc 8.8 0 0 8.8 496.39 427.93 Tm (Rossi, )Tj 0.05 Tc 9.0143 0 0 8.8 524.78 427.93 Tm (A. )Tj 0.0165 Tc 8.8 0 0 8.8 303.43 418.81 Tm (Baldoncini, )Tj 0.05 Tc 8.9962 0 0 8.8 348.55 418.81 Tm (R. )Tj ET BT /Suspect <>BDC /T1_2 1 Tf 0.0083 Tc 8.8 0 0 8.8 360.07 418.81 Tm (Palumbo. )Tj EMC /Suspect <>BDC 0.149 0.149 0.141 rg /T1_0 1 Tf 0.006 Tc -6.394 -1.091 Td (RESUME: )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0236 Tc 8.8 0 0 8.8 348.9996 409.2092 Tm (Nous )Tj 0.0061 Tc 2.931 0 Td (avons )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0239 Tc 8.8 0 0 8.8 402.222 409.2092 Tm (mesure )Tj EMC ET BT /T1_0 1 Tf 0.0152 Tc 8.8 0 0 8.8 434.7908 409.2092 Tm (chez )Tj -0.0013 Tc 2.649 0 Td (13 )Tj 0.0173 Tc 1.672 0 Td (patients )Tj -0.0051 Tc 3.97 0 Td (atteints )Tj 0.0293 Tc -23.181 -1.147 Td (d'oedeme )Tj 0.0106 Tc 4.319 0 Td (pulmonaire )Tj 0.0005 Tc 5.009 0 Td (interstitiel )Tj 0.0074 Tc 4.416 0 Td (cardiogenique )Tj 0.0043 Tc 6.108 0 Td (\(CIPO\) )Tj 0.05 Tc 8.9571 0 0 8.8 507.75 399.12 Tm (et )Tj 0.0152 Tc 8.8 0 0 8.8 517.35 399.12 Tm (chez )Tj 0 Tc -24.273 -1.144 Td (7 )Tj 0.0131 Tc 0.884 0 Td (pati)Tj 0.714 g 0 Tc 1.506 0 Td (.)Tj 0.22 0.22 0.216 rg 0.0157 Tc 0.065 0 Td (ents )Tj 0.0027 Tc 2.073 0 Td (atteints )Tj 0.0478 Tc 3.328 0 Td (de )Tj 0.306 0.31 0.302 rg 0.0333 Tc 1.359 0 Td (synd)Tj 0.149 0.149 0.141 rg 0.0249 Tc 1.976 0 Td (rome )Tj 0.22 0.22 0.216 rg 0.0478 Tc 2.501 0 Td (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.017 Tc 8.8 0 0 8.8 436.7156 389.0528 Tm (detresse )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.013 Tc 8.8 0 0 8.8 469.4252 389.0528 Tm (respiratoire )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0075 Tc 8.8 0 0 8.8 514.4636 389.0528 Tm (aigue )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.2683 0 0 8.8 303.27 378.97 Tm (de )Tj 0.149 0.149 0.141 rg /T1_1 1 Tf 9.3476 0 0 9.1 316.06 378.97 Tm (I' )Tj 0.22 0.22 0.216 rg /T1_0 1 Tf 0.016 Tc 8.8 0 0 8.8 321.51 378.97 Tm (adulte )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0152 Tc 8.8 0 0 8.8 347.4172 378.97 Tm (\(ARDS\), )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.5916 0 0 8.8 383.94 378.97 Tm (Ia )Tj 0.306 0.31 0.302 rg 0.0224 Tc 8.8 0 0 8.8 393.99 378.97 Tm (clearance )Tj 0.149 0.149 0.141 rg 0.0153 Tc 4.372 0 Td (totale )Tj 0.306 0.31 0.302 rg 0.05 Tc 9.5969 0 0 8.8 456.38 378.97 Tm (et )Tj 0.22 0.22 0.216 rg 0.0196 Tc 8.8 0 0 8.8 467.03 378.97 Tm (regionale )Tj -0.0092 Tc 4.247 0 Td (du )Tj 0.011 Tc 1.483 0 Td (pen\255)Tj 0.0483 Tc -24.276 -1.145 Td (tacetate )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.8677 0 0 8.8 339.28 368.89 Tm (diethylene )Tj EMC ET BT /T1_0 1 Tf 0.0471 Tc 8.8 0 0 8.8 386.38 368.89 Tm (triamine )Tj 0.05 Tc 9.7561 0 0 8.8 424.23 368.89 Tm (de )Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /T1_0 1 Tf 9.0287 0 0 8.8 439.12 368.89 Tm (Technecium)Tj 6.5555 0 0 6.4001 487.61 371.76 Tm (99)Tj 8.0102 0 0 6.4001 494.73 368.89 Tm ("' )Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0453 Tc 8.8 0 0 8.8 504.46 368.89 Tm (marque )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 6.9827 0 0 9.4 303.24 358.81 Tm (\(9)Tj 4.5798 0 0 5.7 309.55 361.69 Tm (901)Tj /T1_0 1 Tf 0.0092 Tc 8.8 0 0 8.8 317.21 358.81 Tm (Tc-DTPA\). )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0212 Tc 8.8 0 0 8.8 361.8524 358.81 Tm (Trente-cinq )Tj 0.22 0.22 0.216 rg 0.0191 Tc 5.34 0 Td (sujets )Tj 0.0266 Tc 2.794 0 Td (normaux )Tj 0.0248 Tc 4.19 0 Td (\(22 )Tj 0.149 0.149 0.141 rg 0.0426 Tc 1.81 0 Td (non )Tj 0.22 0.22 0.216 rg -0.0036 Tc 2.063 0 Td (fumeurs )Tj 0.05 Tc 9.5969 0 0 8.8 303.26 349.21 Tm (et )Tj -0.0013 Tc 8.8 0 0 8.8 314.58 349.21 Tm (13 )Tj 0.0039 Tc 1.495 0 Td (fumeurs\) )Tj 0.149 0.149 0.141 rg 0.0262 Tc 4.202 0 Td (ont )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0284 Tc 8.8 0 0 8.8 380.5448 349.21 Tm (ete )Tj EMC /Suspect <>BDC 0.0132 Tc 1.691 0 Td (evalues )Tj EMC ET BT /T1_0 1 Tf 0.0337 Tc 8.8 0 0 8.8 427.1056 349.21 Tm (comme )Tj 0.01 Tc 3.545 0 Td (controles. )Tj -0.035 Tc 9.5452 0 0 9.9 498.19 349.21 Tm (Le )Tj -0.0095 Tc 8.8 0 0 8.8 512.14 349.21 Tm (temps )Tj 0.149 0.149 0.141 rg 0.0282 Tc -23.734 -1.147 Td (demi )Tj 0.22 0.22 0.216 rg 0.0166 Tc 2.516 0 Td (moyen )Tj -0.0067 Tc 3.266 0 Td (de )Tj 0.0156 Tc 1.417 0 Td (clearance )Tj 0.0465 Tc 4.266 0 Td (pour )Tj -0.0014 Tc 2.445 0 Td (les )Tj 0.0173 Tc 1.536 0 Td (patients )Tj 0.0027 Tc 3.752 0 Td (atteints )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0308 Tc 8.8 0 0 8.8 501.9936 339.1164 Tm (d'ARDS )Tj EMC ET BT /T1_0 1 Tf 0.0197 Tc 8.8 0 0 8.8 303.2544 329.0492 Tm (\(poumon )Tj 0.035 Tc 4.093 0 Td (droit )Tj ET BT /Suspect <>BDC 0.149 0.149 0.141 rg /C0_0 1 Tf 0 Tc 6.24 0 0 7.2 360 329.05 Tm <0054>Tj 3.36 0 0 11.04 365.77 325.21 Tm <0032>Tj 0.306 0.31 0.302 rg 2.08 0 0 7.2 369.13 329.05 Tm <002E007E002C0020>Tj EMC ET BT 0.22 0.22 0.216 rg /T1_0 1 Tf 0.024 Tc 8.8 0 0 8.8 379.18 329.05 Tm (minute, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0337 Tc 8.8 0 0 8.8 410.8424 329.05 Tm (M\261so: )Tj EMC ET BT /T1_0 1 Tf 0.0181 Tc 8.8 0 0 8.8 439.8648 329.05 Tm (15.42\2612.5\) )Tj 0.04 Tc 4.93 0 Td (s'avere )Tj 0.008 Tc 3.382 0 Td (signi\255)Tj 0.0107 Tc -23.834 -1.036 Td (ficativement )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0182 Tc 8.8 0 0 8.8 352.7096 319.9332 Tm (\(p>BDC /T1_0 1 Tf 0.0118 Tc 8.8 0 0 8.8 512.5492 319.93 Tm (CIPO )Tj EMC ET BT /T1_0 1 Tf 0.0197 Tc 8.8 0 0 8.8 303.2588 309.37 Tm (\(poumon )Tj 0.149 0.149 0.141 rg 0.0214 Tc 3.984 0 Td (droit )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_3 1 Tf 0 Tc 9.1 0 0 9.1 358.23 309.37 Tm (T)Tj /T1_2 1 Tf 5.8001 0 0 5.8001 363.74 306.49 Tm (0)Tj 0.588 0.497 Td (.)Tj 0.329 -0.497 Td (5)Tj 0.51 0.497 Td (, )Tj EMC ET BT /T1_0 1 Tf 0.0058 Tc 8.8 0 0 8.8 377.26 309.37 Tm (minute, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0473 Tc 8.8 0 0 8.8 407.004 309.37 Tm (M\261so: )Tj EMC ET BT /T1_0 1 Tf 0.0085 Tc 8.8 0 0 8.8 435.252 309.37 Tm (62.15\2618.9\). )Tj 0.0244 Tc 5.13 0 Td (Cette )Tj 0.001 Tc 2.509 0 Td (augmen\255)Tj 0.0148 Tc -22.628 -1.092 Td (tation )Tj 0.0478 Tc 3.048 0 Td (de )Tj -0.035 Tc 8.5916 0 0 8.8 345.54 299.76 Tm (Ia )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0133 Tc 8.8 0 0 8.8 358.57 299.76 Tm (permeabilite )Tj EMC /Suspect <>BDC 0.0172 Tc 5.88 0 Td (epitheliale )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0476 Tc 8.8 0 0 8.8 454.4812 299.76 Tm (des )Tj 0.22 0.22 0.216 rg 0.0222 Tc 2.126 0 Td (espaces )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0032 Tc 8.8 0 0 8.8 507.7476 299.76 Tm (aeriens )Tj EMC /Suspect <>BDC 0.0112 Tc -23.28 -1.091 Td (peripheriques )Tj EMC ET BT /T1_0 1 Tf 0.0281 Tc 8.8 0 0 8.8 357.0212 290.1592 Tm (est )Tj 0.0127 Tc 1.748 0 Td (impressionnante )Tj 0.0105 Tc 7.253 0 Td (dans )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 10.3863 0 0 8.8 457.63 290.16 Tm (I' )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.0088 Tc 8.8 0 0 8.8 463.66 290.16 Tm (ARDS, )Tj EMC /Suspect <>BDC 0.0245 Tc 3.491 0 Td (meme )Tj EMC ET BT /T1_0 1 Tf 0.0483 Tc 8.8 0 0 8.8 521.2912 290.16 Tm (par )Tj 0.0151 Tc -24.83 -1.144 Td (comparaison )Tj 0.149 0.149 0.141 rg 0.0122 Tc 5.782 0 Td (avec )Tj 0.22 0.22 0.216 rg -0.0014 Tc 2.348 0 Td (les )Tj 0.0154 Tc 1.636 0 Td (grands )Tj 0.0055 Tc 3.269 0 Td (fumeurs )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0135 Tc 8.8 0 0 8.8 451.5776 280.0928 Tm (\(p<0.01\). )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.05 Tc 8.8115 0 0 8.8 490.04 280.09 Tm (De )Tj 0.22 0.22 0.216 rg 0.0005 Tc 8.8 0 0 8.8 504.97 280.09 Tm (plus, )Tj 0.0023 Tc 2.447 0 Td (Ia )Tj 0.0214 Tc -25.465 -1.091 Td (perte )Tj 0.0454 Tc 2.553 0 Td (du )Tj 0.0176 Tc 1.474 0 Td (gradient )Tj 0.0096 Tc 3.824 0 Td (vertical )Tj 0.0478 Tc 3.539 0 Td (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0183 Tc 8.8 0 0 8.8 415.21 270.4892 Tm (permeabilite )Tj EMC /Suspect <>BDC 0.0117 Tc 5.661 0 Td (epitheliale )Tj EMC ET BT /T1_0 1 Tf 0.0203 Tc 8.8 0 0 8.8 506.3164 270.4892 Tm (des )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0274 Tc 8.8 0 0 8.8 522.1476 270.4892 Tm (es\255)Tj EMC ET BT /T1_0 1 Tf 0.0205 Tc 8.8 0 0 8.8 302.4116 260.4132 Tm (paces )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0065 Tc 8.8 0 0 8.8 325.934 260.4132 Tm (periph6riques )Tj EMC /Suspect <>BDC 0.0196 Tc 5.933 0 Td (\(PAEP )Tj EMC ET BT /T1_0 1 Tf 0.0478 Tc 8.8 0 0 8.8 406.4804 260.4132 Tm (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0116 Tc 8.8 0 0 8.8 418.4924 260.4132 Tm (l'apeX>PAEP )Tj EMC ET BT /T1_0 1 Tf 0.0478 Tc 8.8 0 0 8.8 471.7588 260.4132 Tm (de )Tj 0 Tc 1.34 0 Td (!a )Tj 0.0072 Tc 1.125 0 Td (base\) )Tj 0 Tc 2.498 0 Td (a )Tj ET BT /Suspect <>BDC 0.306 0.31 0.302 rg /T1_1 1 Tf -0.035 Tc 7.7823 0 0 11.2 522.64 260.41 Tm (ete )Tj EMC /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0.0255 Tc 8.8 0 0 8.8 302.32 250.8 Tm (observee )Tj EMC ET BT /T1_0 1 Tf 0.0105 Tc 8.8 0 0 8.8 337.8368 250.8 Tm (dans )Tj 0.0203 Tc 2.236 0 Td (des )Tj 0.0178 Tc 1.756 0 Td (poumons )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0106 Tc 8.8 0 0 8.8 409.3544 250.8 Tm (oedematies; )Tj EMC ET BT 0.149 0.149 0.141 rg /T1_0 1 Tf 0.0078 Tc 8.8 0 0 8.8 455.9856 250.8 Tm (nous )Tj 0.22 0.22 0.216 rg 0.001 Tc 2.348 0 Td (pensons )Tj 0.0287 Tc 3.644 0 Td (qu'elle )Tj 0.0207 Tc -23.447 -1.144 Td (reflete )Tj 0.149 0.149 0.141 rg 0.0152 Tc 3.11 0 Td (une )Tj 0.22 0.22 0.216 rg 0.0184 Tc 1.899 0 Td (atteinte )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0226 Tc 8.8 0 0 8.8 376.6976 240.7328 Tm (epitheliale )Tj EMC ET BT /T1_0 1 Tf 0.0133 Tc 8.8 0 0 8.8 418.4712 240.7328 Tm (diffuse. )Tj 0.149 0.149 0.141 rg 0.0153 Tc 3.547 0 Td (Toutefois, )Tj 0 Tc 4.72 0 Td (!)Tj 0.306 0.31 0.302 rg 0.0158 Tc 0.349 0 Td ('apparition )Tj 0.22 0.22 0.216 rg -0.0067 Tc -21.761 -1.091 Td (de )Tj 0.05 Tc 9.4329 0 0 8.8 314.31 231.13 Tm (ce )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.013 Tc 8.8 0 0 8.8 326.41 231.13 Tm (phenomene, )Tj EMC ET BT /T1_0 1 Tf 0.0214 Tc 8.8 0 0 8.8 373.8332 231.13 Tm (egalement )Tj 0.05 Tc 8.8211 0 0 8.8 414.15 231.13 Tm (chez )Tj 0.149 0.149 0.141 rg 0.0259 Tc 8.8 0 0 8.8 434.81 231.13 Tm (les )Tj 0.306 0.31 0.302 rg 0.008 Tc 1.578 0 Td (fumeurs, )Tj 0.22 0.22 0.216 rg 0.05 Tc 8.9571 0 0 8.8 484.23 231.13 Tm (et )Tj 0.0043 Tc 8.8 0 0 8.8 494.81 231.13 Tm (le )Tj 0.0119 Tc 1.097 0 Td (manque )Tj 0.0478 Tc -22.97 -1.145 Td (de )Tj 0.0193 Tc 1.364 0 Td (donnees )Tj 0.0105 Tc 3.818 0 Td (dans )Tj -0.035 Tc 8.3683 0 0 8.8 367.87 221.05 Tm (1' )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.014 Tc 8.8 0 0 8.8 373.9 221.05 Tm (ARDS )Tj EMC ET BT /T1_0 1 Tf 0.0141 Tc 8.8 0 0 8.8 400.8104 221.05 Tm (pre-clinique, )Tj 0.026 Tc 5.67 0 Td (nous )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0208 Tc 8.8 0 0 8.8 471.7472 221.05 Tm (empechent )Tj EMC ET BT /T1_0 1 Tf 0.0478 Tc 8.8 0 0 8.8 513.996 221.05 Tm (de )Tj 0.0023 Tc 1.366 0 Td (Ia )Tj 0.0187 Tc -25.422 -1.145 Td (considerer )Tj 0.0337 Tc 4.909 0 Td (comme )Tj 0.037 Tc 3.61 0 Td (un )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0238 Tc 8.8 0 0 8.8 391.676 210.974 Tm (predicteur )Tj EMC /Suspect <>BDC 0.0185 Tc 4.84 0 Td (separe )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.2683 0 0 8.8 462.63 210.97 Tm (de )Tj -0.035 Tc 8.3683 0 0 8.7 476.83 210.97 Tm (1' )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0088 Tc 8.8 0 0 8.8 482.38 210.97 Tm (ARDS. )Tj EMC ET BT /T1_0 1 Tf 0.0236 Tc 8.8 0 0 8.8 513.6376 210.97 Tm (Nous )Tj 0.0142 Tc -24.015 -1.091 Td (concluons )Tj 0.02 Tc 4.583 0 Td (que )Tj 0.0105 Tc 1.909 0 Td (dans )Tj -0.035 Tc 8.3683 0 0 8.8 379.39 201.37 Tm (1' )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0042 Tc 8.8 0 0 8.8 385.42 201.37 Tm (ARDS )Tj EMC ET BT /T1_0 1 Tf 0.0342 Tc 8.8 0 0 8.8 412.5064 201.37 Tm (!'augmentation )Tj 0.0119 Tc 6.734 0 Td (importante )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0067 Tc 8.8 0 0 8.8 514.472 201.37 Tm (de )Tj EMC ET BT /T1_0 1 Tf 0.0023 Tc 8.8 0 0 8.8 526.0088 201.37 Tm (Ia )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 301.8728 191.294 Tm (P )Tj EMC /Suspect <>BDC 0.0407 Tc 0.602 0 Td (AEP )Tj EMC ET BT /T1_0 1 Tf 0.0025 Tc 8.8 0 0 8.8 327.34 191.294 Tm (reflete )Tj 0.0424 Tc 2.892 0 Td (une )Tj 0.0106 Tc 1.844 0 Td (atteinte )Tj 0.0113 Tc 3.339 0 Td (plus )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0076 Tc 8.8 0 0 8.8 416.5104 191.294 Tm (severe )Tj EMC ET BT /T1_0 1 Tf -0.0067 Tc 8.8 0 0 8.8 442.4704 191.294 Tm (de )Tj 0.05 Tc 8.9036 0 0 8.8 454.01 191.29 Tm (la )Tj 0.0139 Tc 8.8 0 0 8.8 463.66 191.29 Tm (membrane )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0063 Tc 8.8 0 0 8.8 504.3864 191.29 Tm (alveolo\255)Tj EMC ET BT /T1_0 1 Tf 0.0139 Tc 8.8 0 0 8.8 302.3032 181.6892 Tm (capillaire )Tj 0.02 Tc 4.31 0 Td (que )Tj 0.0105 Tc 1.964 0 Td (dans )Tj 0.0308 Tc 2.401 0 Td (l'oedeme )Tj 0.0227 Tc 4.264 0 Td (pulmonaire )Tj 0.0154 Tc 5.227 0 Td (interstitiel )Tj 0.0022 Tc 4.635 0 Td (ou )Tj 0.0152 Tc 1.472 0 Td (chez )Tj -0.0297 Tc -24.269 -1.145 Td (Ies )Tj 0.0055 Tc 1.741 0 Td (fumeurs )Tj 0.0478 Tc 3.875 0 Td (de )Tj 0.0109 Tc 1.581 0 Td (cigarette. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.0518 0 0 8.8 404 171.61 Tm (Si )Tj EMC ET BT /T1_0 1 Tf 0.0424 Tc 8.8 0 0 8.8 416.64 171.61 Tm (une )Tj -0.0213 Tc 2.119 0 Td (intervenLion )Tj 0.0063 Tc 5.569 0 Td (therapeutique )Tj 0.0228 Tc -20.735 -1.091 Td (effective )Tj 0.0281 Tc 4.091 0 Td (est )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0068 Tc 8.8 0 0 8.8 351.7576 162.0092 Tm (decouverte, )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.5916 0 0 8.8 397.86 162.01 Tm (Ia )Tj 0.149 0.149 0.141 rg 0.0239 Tc 8.8 0 0 8.8 407.98 162.01 Tm (mesure )Tj 0.22 0.22 0.216 rg 0.0478 Tc 3.43 0 Td (de )Tj -0.035 Tc 8.5916 0 0 8.8 450.66 162.01 Tm (Ia )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 461.24 162.01 Tm (P )Tj EMC /Suspect <>BDC 0.0134 Tc 0.602 0 Td (AEP )Tj EMC ET BT /T1_0 1 Tf 0.017 Tc 8.8 0 0 8.8 486.7248 162.01 Tm (pourrait )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.8 0 0 8.8 519.2672 162.01 Tm (etre )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.1481 0 0 8.8 301.92 151.93 Tm (un )Tj 0.0119 Tc 8.8 0 0 8.8 315.77 151.93 Tm (instrument )Tj 0.023 Tc 4.794 0 Td (salvateur )Tj 0.0105 Tc 4.205 0 Td (dans )Tj 0.0259 Tc 2.401 0 Td (les )Tj 0.0296 Tc 1.576 0 Td (six )Tj 0.0163 Tc 1.706 0 Td (premiers )Tj 0.0325 Tc 4.059 0 Td (jours )Tj 0.0478 Tc 2.531 0 Td (de )Tj 0.306 0.31 0.302 rg 0.0115 Tc 1.472 0 Td (cette )Tj 0.22 0.22 0.216 rg 0.0195 Tc -24.319 -1.091 Td (maladie )Tj 0.004 Tc 3.755 0 Td (fatale, )Tj 0.306 0.31 0.302 rg 0 Tc 3.001 0 Td (c)Tj 0.149 0.149 0.141 rg 0.0391 Tc 0.544 0 Td ('est-a)Tj 0.306 0.31 0.302 rg 0.0118 Tc 2.236 0 Td (-dire )Tj 0.22 0.22 0.216 rg -0.0047 Tc 2.401 0 Td (au )Tj 0.0225 Tc 1.426 0 Td (moment )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.324 0 0 8.8 453.03 142.33 Tm (ou )Tj EMC ET BT /T1_0 1 Tf 8.9642 0 0 8.8 466.43 142.33 Tm (sa )Tj 0.0069 Tc 8.8 0 0 8.8 478.54 142.33 Tm (mortalite )Tj 0.306 0.31 0.302 rg 0.0281 Tc 4.083 0 Td (est )Tj ET BT /Suspect <>BDC 0.22 0.22 0.216 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 528.8672 142.33 Tm (a )Tj EMC ET BT /T1_0 1 Tf 0.0272 Tc 8.8 0 0 8.8 302.276 132.254 Tm (son )Tj 0.149 0.149 0.141 rg 0.0135 Tc 1.758 0 Td (niveau )Tj 0.22 0.22 0.216 rg 0.05 Tc 8.9036 0 0 8.8 345.53 132.25 Tm (le )Tj 0.0295 Tc 8.8 0 0 8.8 355.21 132.25 Tm (plus )Tj -0.015 Tc 2.182 0 Td (bas. )Tj /T1_2 1 Tf 0.0349 Tc -8.231 -1.147 Td (Eur )Tj 0.0354 Tc 1.91 0 Td (Respir )Tj 0.149 0.149 0.141 rg /T1_3 1 Tf -0.0251 Tc 8.6 0 0 8.6 345.52 122.16 Tm (J., )Tj 0.22 0.22 0.216 rg /T1_2 1 Tf -0.0039 Tc 9.2 0 0 9.2 357.92 122.16 Tm (1988, )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.0287 Tc 9.2 0 0 9.2 381.9228 122.16 Tm (1, )Tj EMC ET BT /T1_2 1 Tf 0.019 Tc 9.2 0 0 9.2 391.6104 122.16 Tm (918-922. )Tj ET endstream endobj 33 0 obj <>stream Hd͊zy8 >sRhF^#y QG#Oç==o/ϧ;c_mӷKv|~_oo~y>}~W=|z>{O݇q~?>Ï?o+~ߒ~;%zΏx߽w;>lp?(O?{wٸ^ PZUuTGu^5P5FjFDMԤU PjVjUmFmک]uPuNNE]E5|| _#_k55|| _#_k55|| _#_k55|| _#_k5Z||-_+_kZ||-_+_kZ||-_+_kZ||-_+_ku:||_'_uu:||_'_uu:||_'_uu:||_'_uz||=_/_z||=_/_z||=_/_z||=_/_ || ߀o77 || ߀o77 || ߀o77 || ߀o77 KG#(~? ?G#(~? ?G#(~? ?G#(~? ?z $߄o77MM&|| $߄o77MM&|| $߄o77MM&|| $߄o77MM&||3,ߌo77f||3,ߌo77f||3,ߌo77f||3,ߌo77f|| "߂oȷ[--|| "߂oȷ[--|| "߂oȷ[--|| 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