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/Im1 Do Q BT 0.263 0.267 0.255 rg /T1_0 1 Tf -0.035 Tc 3 Tr 9.1523 0 0 9.9 60.4 780.73 Tm (218 )Tj /T1_1 1 Tf 0.05 Tc 8.5548 0 0 7.8001 227.47 781.21 Tm (L. )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 8.8491 0 0 7.8001 240.44 781.21 Tm (DELAUNOlS, )Tj EMC ET BT 0.18 0.184 0.169 rg /T1_1 1 Tf 8.1464 0 0 7.8001 301.4 781.21 Tm (M. )Tj 0.263 0.267 0.255 rg 8.2361 0 0 7.8001 316.28 781.21 Tm (DELA )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 8.5666 0 0 7.8001 341.27 781.21 Tm (UNOIS )Tj EMC ET BT /T1_1 1 Tf 0.0342 Tc 10.1 0 0 10.1 59.9 757.68 Tm (computer )Tj 0.329 0.333 0.322 rg 0.0288 Tc 4.276 0 Td ('respiratory )Tj 0.263 0.267 0.255 rg 0.0144 Tc 5.098 0 Td (preamplifier )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0333 Tc 10.1 0 0 10.1 208.7841 757.68 Tm (UCB' )Tj EMC ET BT /T1_1 1 Tf 0.0345 Tc 10.1 0 0 10.1 235.0946 757.68 Tm (as )Tj 0.0038 Tc 1.141 0 Td (described )Tj 0.05 Tc 10.15 0 0 10.1 60.01 746.65 Tm (by )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 8.883 0 0 10.1 73.87 746.65 Tm (LULLING )Tj EMC ET BT /T1_2 1 Tf 0.0063 Tc 10.1 0 0 10.1 114.15 746.65 Tm (et )Tj -0.0338 Tc 1.095 0 Td (a/. )Tj /T1_1 1 Tf -0.035 Tc 9.0515 0 0 10.1 138.98 746.65 Tm ([7] )Tj -0.0143 Tc 10.1 0 0 10.1 153.1 746.65 Tm (to )Tj 0.037 Tc 1.133 0 Td (obtain )Tj 0.0302 Tc 3.101 0 Td (pulmonary )Tj 0.0062 Tc 4.94 0 Td (resistance )Tj -0.0232 Tc -18.403 -1.093 Td (\(RL\) )Tj 0.0444 Tc 2.236 0 Td (and )Tj 0.05 Tc 10.1442 0 0 10.1 101.78 735.61 Tm (pu)Tj 0.086 0.086 0.078 rg 0 Tc 10.1 0 0 10.1 112.71 735.61 Tm (l)Tj 0.263 0.267 0.255 rg 0.0366 Tc 0.245 0 Td (monary )Tj 0.0301 Tc 3.556 0 Td (dynamic )Tj 0.0136 Tc 3.945 0 Td (compliance )Tj -0.0324 Tc 5.083 0 Td (\(CL\). )Tj 0.05 Tc 10.4937 0 0 10.1 69.51 724.56 Tm (To )Tj 0.0232 Tc 10.1 0 0 10.1 85.3 724.56 Tm (study )Tj 0.0328 Tc 2.673 0 Td (the )Tj 0.0167 Tc 1.617 0 Td (resistance )Tj 0.05 Tc 11.1292 0 0 10.1 173.65 724.56 Tm (of )Tj 0.0328 Tc 10.1 0 0 10.1 186.22 724.56 Tm (the )Tj 0.0174 Tc 1.655 0 Td (collateral )Tj 0.0257 Tc 4.289 0 Td (pathways )Tj 0.0177 Tc 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0 Td (Wid)Tj 0.329 0.333 0.322 rg 0 Tc 1.75 0 Td (e )Tj 0.263 0.267 0.255 rg 0.0224 Tc 0.674 0 Td (variations )Tj -0.035 Tc 9.9195 0 0 10.1 277.84 659.29 Tm (in )Tj 0.0227 Tc 10.1 0 0 10.1 58.94 648.24 Tm (collateral )Tj 0.0202 Tc 4.38 0 Td (ventilation )Tj 0.0376 Tc 4.935 0 Td (are )Tj 0.017 Tc 1.758 0 Td (observed )Tj 0.0258 Tc 4.182 0 Td (according )Tj 0.0333 Tc 4.618 0 Td (to )Tj 0.009 Tc 1.331 0 Td (the )Tj -0.006 Tc -21.2 -1.046 Td (Jobe )Tj 0.0087 Tc 2.191 0 Td (where )Tj 0.009 Tc 2.946 0 Td (the )Tj 0.0336 Tc 1.608 0 Td (catheter )Tj -0.032 Tc 3.804 0 Td (is )Tj 0.0233 Tc 1.04 0 Td (situated, )Tj 0.0115 Tc 3.957 0 Td (with )Tj 0.0328 Tc 2.233 0 Td (the )Tj 0.0206 Tc 1.704 0 Td (longest )Tj 0.329 0.333 0.322 rg 0.0114 Tc -19.431 -1.092 Td (time )Tj 0.0433 Tc 2.178 0 Td (constant )Tj 0.263 0.267 0.255 rg 0.0471 Tc 3.994 0 Td (in )Tj 0.009 Tc 1.289 0 Td (the )Tj 0.0392 Tc 1.664 0 Td (right )Tj 0.0164 Tc 2.423 0 Td (middle )Tj -0.0016 Tc 3.32 0 Td (lobe. )Tj -0.0011 Tc 2.43 0 Td (We )Tj 0.0133 Tc 1.799 0 Td (avoided )Tj 0.0109 Tc -19.097 -1.093 Td (this )Tj -0.0132 Tc 1.845 0 Td (effect )Tj -0.035 Tc 10.0482 0 0 10.1 104.65 615.61 Tm (by )Tj 0.329 0.333 0.322 rg 0.0053 Tc 10.1 0 0 10.1 118.55 615.61 Tm (wedging )Tj 0.263 0.267 0.255 rg 0.009 Tc 3.896 0 Td (the )Tj 0.431 0.435 0.423 rg 0 Tc 1.608 0 Td (c)Tj 0.329 0.333 0.322 rg 0.0403 Tc 0.428 0 Td (atheter )Tj 0.18 0.184 0.169 rg -0.0005 Tc 3.329 0 Td (in )Tj 0.329 0.333 0.322 rg 0.0328 Tc 1.194 0 Td (the )Tj 0.18 0.184 0.169 rg 0.05 Tc 10.2856 0 0 10.1 240.47 615.61 Tm (nond)Tj 0.329 0.333 0.322 rg 0.0086 Tc 10.1 0 0 10.1 262.45 615.61 Tm (epen\255)Tj 0.263 0.267 0.255 rg 0.0475 Tc -20.149 -1.094 Td (dent )Tj 0.0116 Tc 2.245 0 Td (bronchi. )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0341 Tc 10.1 0 0 10.1 119.9087 604.5606 Tm (One )Tj EMC ET BT 0.329 0.333 0.322 rg /T1_1 1 Tf 0.0093 Tc 10.1 0 0 10.1 141.0379 604.5606 Tm (lumen )Tj 0.0165 Tc 2.957 0 Td (provided )Tj 0.263 0.267 0.255 rg 0 Tc 4.075 0 Td (a )Tj 0.329 0.333 0.322 rg 0.0275 Tc 0.808 0 Td (channe)Tj 0.18 0.184 0.169 rg 0 Tc 2.995 0 Td (l )Tj 0.329 0.333 0.322 rg 0.0252 Tc 0.616 0 Td (for )Tj 0.263 0.267 0.255 rg 0.0328 Tc 1.577 0 Td (the )Tj 0.0365 Tc -21.156 -1.092 Td (constant )Tj 0.0096 Tc 3.947 0 Td (infusion )Tj 0.329 0.333 0.322 rg 0.05 Tc 11.1292 0 0 10.1 136.69 593.53 Tm (of )Tj 0.0067 Tc 10.1 0 0 10.1 149.19 593.53 Tm (gas )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0002 Tc 9.9 0 0 9.9 166.87 593.53 Tm (\(V)Tj 0.431 0.435 0.423 rg 0 Tc 1.018 0 Td (\) )Tj EMC ET BT 0.329 0.333 0.322 rg /T1_1 1 Tf -0.0071 Tc 10.1 0 0 10.1 184.31 593.53 Tm (while )Tj 0.263 0.267 0.255 rg 0.009 Tc 2.613 0 Td (the )Tj 0.0108 Tc 1.604 0 Td (second )Tj 0.0093 Tc 3.237 0 Td (lumen )Tj 0.0055 Tc -19.866 -1.046 Td (allowed )Tj 0.009 Tc 3.572 0 Td (the )Tj 0.024 Tc 1.568 0 Td (measurement )Tj 0.05 Tc 11.1292 0 0 10.1 170.29 582.97 Tm (of )Tj 0.0212 Tc 10.1 0 0 10.1 181.94 582.97 Tm (pressure )Tj 0.0254 Tc 3.743 0 Td (distal )Tj 0.0333 Tc 2.622 0 Td (to )Tj 0.0328 Tc 1.188 0 Td (the )Tj 0.0207 Tc 1.616 0 Td (tip )Tj 0.05 Tc 11.1292 0 0 10.1 58.93 571.92 Tm (of )Tj 0.0328 Tc 10.1 0 0 10.1 71.02 571.92 Tm (the )Tj 0.0336 Tc 1.56 0 Td (catheter )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0343 Tc 10.1 0 0 10.1 123.7117 571.92 Tm (\(Pb\))Tj 0 g 0 Tc 1.845 0 Td (. )Tj EMC /Suspect <>BDC 0.263 0.267 0.255 rg /T1_0 1 Tf 11.7 0 0 11.7 147.83 571.92 Tm (V )Tj EMC ET BT /T1_1 1 Tf -0.0144 Tc 10.1 0 0 10.1 158.39 571.92 Tm (was )Tj 0.329 0.333 0.322 rg 0.0202 Tc 1.845 0 Td (administered )Tj 0.263 0.267 0.255 rg -0.0132 Tc 5.758 0 Td (via )Tj 0 Tc 1.513 0 Td (a )Tj 0.0266 Tc 0.861 0 Td (Fisher )Tj 0.0444 Tc -19.824 -1.092 Td (and )Tj ET BT /Suspect <>BDC 0.18 0.184 0.169 rg /T1_1 1 Tf 0.0469 Tc 10.1 0 0 10.1 79.1454 560.8908 Tm (Porter )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_1 1 Tf 0.0013 Tc 10.1 0 0 10.1 110.2837 560.8908 Tm (flowmeter )Tj 0.0394 Tc 4.609 0 Td (\(Fiowrator )Tj 0.0294 Tc 5.048 0 Td (tube )Tj 0.0244 Tc 2.287 0 Td (No. )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 9.7894 0 0 10.1 251.48 560.89 Tm (F.P )Tj EMC ET BT 0.086 0.086 0.078 rg /T1_0 1 Tf 0 Tc 9.4 0 0 9.4 265.18 560.89 Tm (I )Tj 0.263 0.267 0.255 rg /T1_1 1 Tf 0.0018 Tc 10.1 0 0 10.1 268.8 560.89 Tm (/16-)Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0044 Tc 10.1 0 0 10.1 58.9826 549.8507 Tm (20-6-5/36, )Tj EMC ET BT /T1_1 1 Tf 0.0256 Tc 10.1 0 0 10.1 103.5842 549.8507 Tm (air )Tj 0.329 0.333 0.322 rg 0.0269 Tc 1.331 0 Td (calibratio)Tj 0.18 0.184 0.169 rg 0 Tc 4.049 0 Td (n )Tj 0.263 0.267 0.255 rg 0.751 0 Td (G )Tj -0.0247 Tc 1.045 0 Td (9143 )Tj 0.18 0.184 0.169 rg 0 Tc 2.24 0 Td (B)Tj 0.329 0.333 0.322 rg 0.654 0 Td (, )Tj 0.263 0.267 0.255 rg 0.0115 Tc 0.49 0 Td (with )Tj 0.329 0.333 0.322 rg 0.0314 Tc 2.078 0 Td (sapp)Tj 0.18 0.184 0.169 rg 0.0172 Tc 1.961 0 Td (hir)Tj 0.329 0.333 0.322 rg 0 Tc 1.178 0 Td (e )Tj 0.263 0.267 0.255 rg 0.0444 Tc 0.666 0 Td (and )Tj 0.329 0.333 0.322 rg 0.0214 Tc -20.915 -1.046 Td (stainle)Tj 0.431 0.435 0.423 rg -0.035 Tc 10.0314 0 0 10.1 86.26 539.29 Tm (ss )Tj 0 Tc 10.1 0 0 10.1 98.26 539.29 Tm (s)Tj 0.329 0.333 0.322 rg -0.0338 Tc 0.44 0 Td (tee)Tj 0.18 0.184 0.169 rg 0 Tc 1.181 0 Td (l )Tj 0.329 0.333 0.322 rg 0.723 0 Td (b)Tj 0.431 0.435 0.423 rg 0.511 0 Td (e)Tj 0.329 0.333 0.322 rg 0.05 Tc 10.2654 0 0 10.1 131.42 539.29 Tm (ad)Tj 0.431 0.435 0.423 rg 0.0041 Tc 10.1 0 0 10.1 141.94 539.29 Tm (s, )Tj 0.329 0.333 0.322 rg -0.0274 Tc 1.152 0 Td (me)Tj 0.431 0.435 0.423 rg -0.013 Tc 1.228 0 Td (as)Tj 0.263 0.267 0.255 rg 0.0192 Tc 0.913 0 Td (uring )Tj -0.0254 Tc 2.65 0 Td (flows )Tj 0.0093 Tc 2.673 0 Td (between )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0058 Tc 10.1 0 0 10.1 267.7355 539.29 Tm (0.05 )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 10.3398 0 0 10.1 58.45 528.24 Tm (and )Tj 0 Tc 10.1 0 0 10.1 78.13 528.24 Tm (7 )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 10.182 0 0 10.1 87.34 528.24 Tm (ml\267s)Tj 0.694 0.694 0.682 rg 0 Tc 10.1 0 0 10.1 107.4 528.24 Tm (-)Tj 0.263 0.267 0.255 rg 6.5001 0 0 6.5001 114.02 532.09 Tm (1)Tj 0.471 -0.592 Td (\))Tj 0.431 0.435 0.423 rg 0.582 0 Td (, )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_1 1 Tf 0.026 Tc 10.1 0 0 10.1 127.12 528.24 Tm (into )Tj 0.009 Tc 2.05 0 Td (the )Tj -0.0029 Tc 1.664 0 Td (wedged )Tj 0.0197 Tc 3.456 0 Td (segment )Tj 0.05 Tc 11.1292 0 0 10.1 237.97 528.24 Tm (of )Tj 0.009 Tc 10.1 0 0 10.1 250.54 528.24 Tm (the )Tj 0.0147 Tc 1.609 0 Td (lung )Tj 0.0058 Tc -20.569 -1.092 Td (until )Tj 0.329 0.333 0.322 rg 0 Tc 2.176 0 Td (a )Tj 0.431 0.435 0.423 rg 0.756 0 Td (s)Tj 0.329 0.333 0.322 rg 0.0167 Tc 0.44 0 Td (tead)Tj 0.431 0.435 0.423 rg -0.035 Tc 10.0289 0 0 10.1 111.35 517.21 Tm (y-s)Tj 0.263 0.267 0.255 rg 0.0119 Tc 10.1 0 0 10.1 123.82 517.21 Tm (tate )Tj 0.329 0.333 0.322 rg 0.05 Tc 11.1292 0 0 10.1 141.97 517.21 Tm (of )Tj 0.431 0.435 0.423 rg 0 Tc 10.1 0 0 10.1 153.49 517.21 Tm (e)Tj 0.263 0.267 0.255 rg 0.0013 Tc 0.485 0 Td (nd)Tj 0.431 0.435 0.423 rg 0 Tc 1.035 0 Td (-)Tj 0.329 0.333 0.322 rg 0.0265 Tc 0.334 0 Td (expiratory )Tj ET BT /Suspect <>BDC 0.18 0.184 0.169 rg /T1_1 1 Tf -0.035 Tc 9.6532 0 0 10.1 218.68 517.21 Tm (.Pb )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_1 1 Tf 0.0094 Tc 10.1 0 0 10.1 233.75 517.21 Tm (was )Tj 0.329 0.333 0.322 rg 0.0322 Tc 1.853 0 Td (reac)Tj 0.18 0.184 0.169 rg 0.0171 Tc 1.758 0 Td (hed )Tj 0.263 0.267 0.255 rg 0.0223 Tc -20.969 -1.094 Td (\(mean )Tj -0.033 Tc 3.233 0 Td (flow: )Tj 0 Tc 2.761 0 Td (2 )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 9.9355 0 0 10.1 130.54 506.16 Tm (ml)Tj 0.086 0.086 0.078 rg 0 Tc 10.1 0 0 10.1 142.35 506.16 Tm (\267)Tj 0.329 0.333 0.322 rg 0.387 0 Td (s)Tj 0.431 0.435 0.423 rg 0.477 0 Td (-)Tj 0.329 0.333 0.322 rg 6.2 0 0 6.2 157.71 510 Tm (1)Tj 0.05 Tc 8.598 0 0 6.2 160.75 506.16 Tm (\). )Tj EMC ET BT 0.18 0.184 0.169 rg /T1_1 1 Tf 0.0396 Tc 10.1 0 0 10.1 173.19 506.16 Tm (The )Tj 0.329 0.333 0.322 rg 0.0242 Tc 2.336 0 Td (ventilator )Tj 0.263 0.267 0.255 rg 0.0094 Tc 4.706 0 Td (was )Tj 0.0294 Tc 2.233 0 Td (then )Tj 0.0247 Tc -20.638 -1.093 Td (stopped )Tj 0.329 0.333 0.322 rg 0.0444 Tc 3.711 0 Td (and )Tj 0.263 0.267 0.255 rg 0.0167 Tc 1.956 0 Td (measurements )Tj 0.004 Tc 6.322 0 Td (were )Tj 0.025 Tc 2.328 0 Td (made )Tj 0.05 Tc 10.7518 0 0 10.1 229.81 495.12 Tm (at )Tj 0.0178 Tc 10.1 0 0 10.1 242.29 495.12 Tm (functional )Tj 0.329 0.333 0.322 rg -0.0121 Tc -18.192 -1.046 Td (res)Tj 0.18 0.184 0.169 rg 0.0394 Tc 1.181 0 Td (idual )Tj 0.329 0.333 0.322 rg 0.0233 Tc 2.422 0 Td (capacity )Tj 0.0435 Tc 3.848 0 Td (\(FRC\) )Tj 0.0333 Tc 3.099 0 Td (to )Tj 0.263 0.267 0.255 rg 0.0181 Tc 1.18 0 Td (avoid )Tj 0.0215 Tc 2.661 0 Td (changes )Tj 0.0434 Tc 3.707 0 Td (due )Tj 0.329 0.333 0.322 rg 0.0333 Tc 1.861 0 Td (to )Tj 0.263 0.267 0.255 rg 0.009 Tc 1.236 0 Td (the )Tj 0.01 Tc -21.196 -1.092 Td (volume )Tj 0.18 0.184 0.169 rg 0 Tc 3.652 0 Td (l)Tj 0.329 0.333 0.322 rg 0.006 Tc 0.236 0 Td (eve)Tj 0.18 0.184 0.169 rg 0 Tc 1.38 0 Td (l )Tj -0.035 Tc 9.4074 0 0 10.1 120.25 473.53 Tm ([8]. )Tj 0.263 0.267 0.255 rg 0.0148 Tc 10.1 0 0 10.1 139.65 473.53 Tm (When )Tj -0.0309 Tc 3.034 0 Td (flow )Tj 0.0286 Tc 2.433 0 Td (through )Tj 0.009 Tc 3.945 0 Td (the )Tj -0.0124 Tc 1.902 0 Td (wedged )Tj 0.0197 Tc -19.403 -1.093 Td (segment )Tj -0.0144 Tc 4.005 0 Td (was )Tj 0.18 0.184 0.169 rg -0.0076 Tc 2.082 0 Td (di)Tj 0.329 0.333 0.322 rg 0.012 Tc 0.804 0 Td (sco)Tj 0.18 0.184 0.169 rg 0.0457 Tc 1.344 0 Td (ntinu)Tj 0.329 0.333 0.322 rg 0.0074 Tc 2.224 0 Td (ed, )Tj ET BT /Suspect <>BDC 0.18 0.184 0.169 rg /T1_1 1 Tf 0.05 Tc 10.5625 0 0 10.1 181.39 462.49 Tm (Pb )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_1 1 Tf 0.0106 Tc 10.1 0 0 10.1 198.62 462.49 Tm (decayed )Tj 0.0345 Tc 3.897 0 Td (as )Tj 0.009 Tc 1.481 0 Td (the )Tj 0.0328 Tc 1.798 0 Td (ob\255)Tj 0.329 0.333 0.322 rg 0.0271 Tc -21.105 -1.094 Td (structed )Tj 0.0118 Tc 4.135 0 Td (segment )Tj 0.0379 Tc 4.138 0 Td (empt)Tj 0.18 0.184 0.169 rg 0 Tc 2.142 0 Td (i)Tj 0.329 0.333 0.322 rg 0.0272 Tc 0.235 0 Td (ed )Tj 0.263 0.267 0.255 rg 0.0286 Tc 1.815 0 Td (through )Tj 0.009 Tc 4.135 0 Td (the )Tj 0.0174 Tc 1.988 0 Td (collateral )Tj 0.0257 Tc -18.57 -1.045 Td (pathways )Tj -0.035 Tc 10.0124 0 0 10.1 101.64 440.89 Tm (\(fig. )Tj 0.18 0.184 0.169 rg -0.0006 Tc 9.6 0 0 9.6 122.81 440.89 Tm (I\). )Tj 0.0371 Tc 10.1 0 0 10.1 68.09 429.84 Tm (In )Tj 0.263 0.267 0.255 rg 0.0183 Tc 1.134 0 Td (some )Tj 0.014 Tc 2.38 0 Td (dogs, )Tj 0.05 Tc 10.2654 0 0 10.1 128.54 429.84 Tm (an )Tj 0.0223 Tc 10.1 0 0 10.1 141.5 429.84 Tm (obvious )Tj 0.0028 Tc 3.566 0 Td (initial )Tj 0.004 Tc 2.658 0 Td (fast )Tj 0.0415 Tc 1.759 0 Td (drop )Tj -0.0005 Tc 2.236 0 Td (in )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0049 Tc 10.1 0 0 10.1 255.7815 429.84 Tm (Pb )Tj EMC ET BT /T1_1 1 Tf -0.0144 Tc 10.1 0 0 10.1 269.265 429.84 Tm (was )Tj 0.0058 Tc -20.921 -1.092 Td (followed )Tj 0.0076 Tc 3.909 0 Td (by )Tj 0.05 Tc 10.2654 0 0 10.1 110.78 418.81 Tm (an )Tj 0.0255 Tc 10.1 0 0 10.1 123.73 418.81 Tm (exponential )Tj -0.0021 Tc 5.181 0 Td (decline: )Tj 0.329 0.333 0.322 rg 0.0328 Tc 3.525 0 Td (the )Tj 0.263 0.267 0.255 rg 0.0199 Tc 1.559 0 Td (fast )Tj 0.05 Tc 10.2128 0 0 10.1 245.66 418.81 Tm (drop )Tj -0.0144 Tc 10.1 0 0 10.1 269.27 418.81 Tm (was )Tj 0.0354 Tc -20.92 -1.094 Td (attributed )Tj 0.0333 Tc 4.76 0 Td (to )Tj 0.0328 Tc 1.426 0 Td (the )Tj 0.0094 Tc 1.854 0 Td (resistances )Tj -0.0005 Tc 4.983 0 Td (in )Tj 0.009 Tc 1.432 0 Td (the )Tj 0.0206 Tc 1.848 0 Td (intrasegmental )Tj 0.0176 Tc -16.35 -1.14 Td (airways, )Tj 0.0097 Tc 3.953 0 Td (whereas )Tj 0.009 Tc 3.849 0 Td (the )Tj 0.0269 Tc 1.699 0 Td (subsequent )Tj 0.0338 Tc 5.09 0 Td (gradual )Tj 0.0121 Tc 3.658 0 Td (decline )Tj 0.05 Tc 10.5727 0 0 10.1 276.38 396.25 Tm (of )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 10.1224 0 0 10.1 58.03 385.69 Tm (Pb )Tj EMC ET BT /T1_1 1 Tf 0.0094 Tc 10.1 0 0 10.1 76.31 385.69 Tm (was )Tj 0.0301 Tc 2.272 0 Td (attributed )Tj -0.0143 Tc 4.903 0 Td (to )Tj 0.0148 Tc 1.513 0 Td (deflation )Tj 0.05 Tc 11.1292 0 0 10.1 208.21 385.69 Tm (of )Tj 0.009 Tc 10.1 0 0 10.1 224.62 385.69 Tm (the )Tj 0.0215 Tc 1.941 0 Td (distended )Tj 0.0309 Tc -18.487 -1.093 Td (obstructed )Tj 0.0197 Tc 4.986 0 Td (segment )Tj 0.0365 Tc 4.004 0 Td (through )Tj 0.0227 Tc 3.842 0 Td (collateral )Tj 0.0196 Tc 4.467 0 Td (channels )Tj -0.035 Tc 9.5041 0 0 10.1 274.33 374.65 Tm ([5] )Tj 10.0124 0 0 10.1 57.96 363.61 Tm (\(fig. )Tj 0.086 0.086 0.078 rg /T1_0 1 Tf 0 Tc 9.9 0 0 9.9 80.37 363.61 Tm (I)Tj 0.263 0.267 0.255 rg -0.035 Tc 9.6722 0 0 9.9 83.83 363.61 Tm (\). )Tj /T1_1 1 Tf 0.0148 Tc 10.1 0 0 10.1 95.49 363.61 Tm (When )Tj 0.18 0.184 0.169 rg 0.05 Tc 10.1755 0 0 10.1 125.3 363.61 Tm (plo)Tj 0.329 0.333 0.322 rg 0.0404 Tc 10.1 0 0 10.1 139.18 363.61 Tm (tted )Tj 0.263 0.267 0.255 rg -0.013 Tc 2.178 0 Td (as )Tj 0 Tc 1.378 0 Td (a )Tj 0.0221 Tc 0.962 0 Td (percentage )Tj 0.05 Tc 11.1292 0 0 10.1 235.57 363.61 Tm (of )Tj 0.0144 Tc 10.1 0 0 10.1 250.1 363.61 Tm (pressure )Tj 0.018 Tc -19.069 -1.094 Td (change )Tj 0.05 Tc 10.2564 0 0 10.1 89.66 352.56 Tm (on )Tj 0.329 0.333 0.322 rg -0.0024 Tc 10.1 0 0 10.1 103.54 352.56 Tm (semi)Tj 0.18 0.184 0.169 rg 0 Tc 1.906 0 Td (l)Tj 0.329 0.333 0.322 rg 0.0231 Tc 0.284 0 Td (ogarithmic )Tj 0.263 0.267 0.255 rg 0.0308 Tc 4.812 0 Td (paper, )Tj 0.0328 Tc 2.943 0 Td (the )Tj 0.0259 Tc 1.609 0 Td (gradual )Tj 0.0042 Tc 3.468 0 Td (decline )Tj 0.05 Tc 11.1292 0 0 10.1 57.49 341.53 Tm (of )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 10.1224 0 0 10.1 70.03 341.53 Tm (Pb )Tj EMC ET BT /T1_1 1 Tf 0.0331 Tc 10.1 0 0 10.1 84.86 341.53 Tm (approximated )Tj 0 Tc 6.226 0 Td (a )Tj 0.329 0.333 0.322 rg 0.0075 Tc 0.851 0 Td (sing)Tj 0.18 0.184 0.169 rg -0.035 Tc 10.0336 0 0 10.1 173.68 341.53 Tm (le )Tj 0.263 0.267 0.255 rg 0.0207 Tc 10.1 0 0 10.1 184.21 341.53 Tm (exponential )Tj -0.0009 Tc 5.229 0 Td (curve: )Tj 0.0316 Tc 2.954 0 Td (thus )Tj -0.0148 Tc -20.673 -1.093 Td (the )Tj 0.18 0.184 0.169 rg 0.0242 Tc 1.902 0 Td (rate )Tj 0.263 0.267 0.255 rg 0.05 Tc 10.7518 0 0 10.1 99.73 330.49 Tm (at )Tj -0.0034 Tc 10.1 0 0 10.1 114.71 330.49 Tm (which )Tj 0.0328 Tc 3.136 0 Td (the )Tj 0.0144 Tc 1.952 0 Td (pressure )Tj 0.01 Tc 4.075 0 Td (decreases )Tj 0.05 Tc 10.1505 0 0 10.1 253.34 330.49 Tm (can )Tj -0.0304 Tc 10.1 0 0 10.1 275.53 330.49 Tm (be )Tj 0.0166 Tc -21.635 -1.094 Td (conveniently )Tj 0.18 0.184 0.169 rg 0.0157 Tc 5.56 0 Td (described )Tj 0.263 0.267 0.255 rg 0.0345 Tc 4.23 0 Td (as )Tj 0.009 Tc 1.196 0 Td (the )Tj 0.329 0.333 0.322 rg 0.0114 Tc 1.521 0 Td (time )Tj 0.263 0.267 0.255 rg 0.0324 Tc (it )Tj 0.0222 Tc 2.947 0 Td (takes )Tj 0.0333 Tc 2.471 0 Td (to )Tj 0.0195 Tc 1.038 0 Td (decrease )Tj 0.0225 Tc -18.918 -1.092 Td (63% )Tj -0.0071 Tc 2.472 0 Td (\(//e\) )Tj 0.05 Tc 11.1292 0 0 10.1 104.53 308.41 Tm (of )Tj 0.009 Tc 10.1 0 0 10.1 118.54 308.41 Tm (the )Tj 0.0205 Tc 1.853 0 Td (total )Tj 0.0059 Tc 2.416 0 Td (decrease )Tj -0.035 Tc 9.4074 0 0 10.1 202.33 308.41 Tm ([9]. )Tj 0.0371 Tc 10.1 0 0 10.1 220.73 308.41 Tm (In )Tj 0.0183 Tc 1.419 0 Td (some )Tj 0.014 Tc 2.665 0 Td (dogs, )Tj 0.0277 Tc -20.25 -1.047 Td (stopping )Tj 0.0328 Tc 4.147 0 Td (the )Tj -0.0309 Tc 1.845 0 Td (flow )Tj -0.0144 Tc 2.339 0 Td (was )Tj 0.329 0.333 0.322 rg 0.0152 Tc 2.082 0 Td (associated )Tj 0.263 0.267 0.255 rg 0.0115 Tc 4.809 0 Td (with )Tj 0.05 Tc 10.2654 0 0 10.1 235.1 297.84 Tm (an )Tj 0.0302 Tc 10.1 0 0 10.1 250.94 297.84 Tm (obvious )Tj 0.0028 Tc -19.15 -1.092 Td (initial )Tj 0.004 Tc 2.706 0 Td (fast )Tj 0.05 Tc 10.456 0 0 10.1 102.62 286.81 Tm (drop )Tj 0.329 0.333 0.322 rg -0.0264 Tc 10.1 0 0 10.1 126.12 286.81 Tm (\(fig. )Tj 0.263 0.267 0.255 rg 0 Tc 2.021 0 Td (1 )Tj -0.035 Tc 9.4948 0 0 10.1 150.66 286.81 Tm (\); )Tj 0.329 0.333 0.322 rg 0.0109 Tc 10.1 0 0 10.1 159.82 286.81 Tm (this )Tj 0.263 0.267 0.255 rg 0.0001 Tc 1.798 0 Td (difference )Tj 0.0327 Tc 4.311 0 Td (jn )Tj 0.0328 Tc 1.162 0 Td (the )Tj 0.329 0.333 0.322 rg 0.0197 Tc 1.556 0 Td (speed )Tj 0.263 0.267 0.255 rg 0.05 Tc 11.1292 0 0 10.1 275.89 286.81 Tm (of )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0049 Tc 10.1 0 0 10.1 57.55 275.76 Tm (Pb )Tj EMC ET BT /T1_1 1 Tf 0.0042 Tc 10.1 0 0 10.1 72.8616 275.76 Tm (decline )Tj 0.0196 Tc 3.374 0 Td (occurred )Tj -0.035 Tc 9.9195 0 0 10.1 148.72 275.76 Tm (in )Tj 0.035 Tc 10.1 0 0 10.1 161.26 275.76 Tm (most )Tj 0.329 0.333 0.322 rg 0.0386 Tc 2.463 0 Td (control )Tj 0.021 Tc 3.525 0 Td (measurements)Tj 0.431 0.435 0.423 rg 0 Tc 5.974 0 Td (, )Tj 0.263 0.267 0.255 rg 0.0316 Tc -22.225 -1.093 Td (but )Tj -0.0144 Tc 2.089 0 Td (was )Tj 0.003 Tc 2.284 0 Td (perceived )Tj 0.329 0.333 0.322 rg 0.0164 Tc 4.693 0 Td (only )Tj 0.263 0.267 0.255 rg 0.0076 Tc 2.577 0 Td (by )Tj 0.329 0.333 0.322 rg 0.025 Tc 1.748 0 Td (calculation )Tj 0.263 0.267 0.255 rg -0.0005 Tc 5.372 0 Td (in )Tj 0.329 0.333 0.322 rg 0.0183 Tc 1.515 0 Td (some )Tj 0.263 0.267 0.255 rg 0.0178 Tc -20.337 -1.092 Td (animals, )Tj 0.0444 Tc 4.325 0 Td (and )Tj 0.0094 Tc 2.385 0 Td (was )Tj 0.05 Tc 10.1333 0 0 10.1 149.27 253.69 Tm (not )Tj 0.0158 Tc 10.1 0 0 10.1 171.76 253.69 Tm (immediately )Tj 0.0302 Tc 5.939 0 Td (obvious )Tj -0.035 Tc 10.0482 0 0 10.1 274.57 253.69 Tm (by )Tj 0.008 Tc 10.1 0 0 10.1 57.52 242.65 Tm (inspection. )Tj 0.05 Tc 10.4937 0 0 10.1 106.47 242.65 Tm (To )Tj 0.037 Tc 10.1 0 0 10.1 121.82 242.65 Tm (ca)Tj 0.086 0.086 0.078 rg 0 Tc 0.999 0 Td (l)Tj 0.263 0.267 0.255 rg 0.0312 Tc 0.237 0 Td (culate )Tj 0.086 0.086 0.078 rg 0 Tc 2.901 0 Td (i)Tj 0.263 0.267 0.255 rg 0.0245 Tc 0.292 0 Td (ntrasegmental )Tj 0.0194 Tc 6.264 0 Td (airway )Tj -0.005 Tc 3.241 0 Td (resis\255)Tj 0.0087 Tc -20.294 -1.046 Td (tance )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0254 Tc 10.1 0 0 10.1 81.9654 232.0854 Tm (\(Rsaw\) )Tj EMC ET BT /T1_1 1 Tf 0.0444 Tc 10.1 0 0 10.1 115.5883 232.0854 Tm (and )Tj 0.0328 Tc 1.909 0 Td (the )Tj 0.0202 Tc 1.568 0 Td (mechanics )Tj 0.05 Tc 11.1292 0 0 10.1 197.65 232.09 Tm (of )Tj 0.028 Tc 10.1 0 0 10.1 209.66 232.09 Tm (collateral )Tj 0.0132 Tc 4.238 0 Td (ventila\255)Tj 0.013 Tc -19.343 -1.093 Td (tion, )Tj 0.021 Tc 2.186 0 Td (measurements )Tj 0.05 Tc 11.1292 0 0 10.1 142.45 221.05 Tm (of )Tj ET BT /Suspect <>BDC 0.18 0.184 0.169 rg /T1_1 1 Tf -0.035 Tc 9.251 0 0 10.1 153.89 221.05 Tm (.Pb )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_1 1 Tf -0.0119 Tc 10.1 0 0 10.1 168.47 221.05 Tm (were )Tj 0.0409 Tc 2.185 0 Td (made )Tj -0.0033 Tc 2.557 0 Td (every )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0036 Tc 10.1 0 0 10.1 241.8162 221.05 Tm (0.2 )Tj EMC ET BT 0.329 0.333 0.322 rg /T1_1 1 Tf 0 Tc 10.1 0 0 10.1 257.1379 221.05 Tm (s )Tj 0.263 0.267 0.255 rg 0.0252 Tc 0.668 0 Td (for )Tj 0.086 0.086 0.078 rg /T1_0 1 Tf 0 Tc 9.8 0 0 9.8 280.53 221.05 Tm (I )Tj 0.329 0.333 0.322 rg /T1_1 1 Tf 10.1 0 0 10.1 56.98 210.01 Tm (s )Tj 0.0326 Tc 0.717 0 Td (after )Tj 0.263 0.267 0.255 rg 0.0277 Tc (stopping )Tj 0.329 0.333 0.322 rg 0.009 Tc 6.329 0 Td (the )Tj ET BT /Suspect <>BDC 0.18 0.184 0.169 rg /T1_1 1 Tf -0.0309 Tc 10.1 0 0 10.1 144.3753 210.01 Tm (flow )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_1 1 Tf -0.0264 Tc 10.1 0 0 10.1 165.9691 210.01 Tm (\(fig. )Tj 0.0079 Tc 9.8 0 0 9.8 186.66 210.01 Tm (J\). )Tj 0.0396 Tc 10.1 0 0 10.1 200.55 210.01 Tm (The )Tj 0.18 0.184 0.169 rg 0.05 Tc 10.4349 0 0 10.1 220.82 210.01 Tm (pr)Tj 0.329 0.333 0.322 rg 0.0178 Tc 10.1 0 0 10.1 229.81 210.01 Tm (essure )Tj 0.263 0.267 0.255 rg -0.035 Tc 9.9195 0 0 10.1 259.6 210.01 Tm (in )Tj 0.009 Tc 10.1 0 0 10.1 271.66 210.01 Tm (the )Tj 0.329 0.333 0.322 rg 0.0204 Tc -21.251 -1.093 Td (obstructed )Tj 0.0197 Tc 4.653 0 Td (segment )Tj 0.263 0.267 0.255 rg 0.05 Tc 11.1292 0 0 10.1 141.49 198.97 Tm (of )Tj 0.009 Tc 10.1 0 0 10.1 153.58 198.97 Tm (the )Tj 0.0306 Tc 1.514 0 Td (lung )Tj 0.0393 Tc 2.15 0 Td (prior )Tj 0.0333 Tc 2.372 0 Td (to )Tj 0.329 0.333 0.322 rg 0.0392 Tc 1.129 0 Td (stop )Tj 0.263 0.267 0.255 rg -0.0309 Tc 2.047 0 Td (flow )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0079 Tc 10.1 0 0 10.1 267.7302 198.97 Tm (\(Ps\) )Tj EMC ET BT /T1_1 1 Tf -0.0144 Tc 10.1 0 0 10.1 56.6402 187.9307 Tm (was )Tj 0.0174 Tc 1.987 0 Td (calculated )Tj 0.18 0.184 0.169 rg 0.0113 Tc 4.751 0 Td (from )Tj 0.263 0.267 0.255 rg 0.05 Tc 10.2654 0 0 10.1 150.14 187.93 Tm (an )Tj 0.0338 Tc 10.1 0 0 10.1 165.01 187.93 Tm (extrapolation )Tj 0.0365 Tc 6.187 0 Td (through )Tj 0.329 0.333 0.322 rg 0.0167 Tc 3.846 0 Td (zero )Tj 0.263 0.267 0.255 rg -0.0044 Tc -20.717 -1.093 Td (time )Tj 0.05 Tc 11.1292 0 0 10.1 81.97 176.89 Tm (of )Tj 0.0328 Tc 10.1 0 0 10.1 97.42 176.89 Tm (the )Tj 0.0214 Tc 1.989 0 Td (least-square )Tj 0.18 0.184 0.169 rg 0.0142 Tc 5.703 0 Td (linear )Tj 0.263 0.267 0.255 rg 0.0084 Tc 3.05 0 Td (regression )Tj 0.05 Tc 11.1292 0 0 10.1 255.25 176.89 Tm (of )Tj 0.0328 Tc 10.1 0 0 10.1 271.18 176.89 Tm (the )Tj 0.0273 Tc -21.298 -1.046 Td (logarithm )Tj 0.05 Tc 11.1292 0 0 10.1 100.69 166.33 Tm (of )Tj 0.0328 Tc 10.1 0 0 10.1 112.3 166.33 Tm (the )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0036 Tc 10.1 0 0 10.1 128.056 166.33 Tm (0.2 )Tj EMC ET BT /T1_1 1 Tf 0 Tc 10.1 0 0 10.1 143.3777 166.33 Tm (s )Tj 0.021 Tc 0.677 0 Td (measurements )Tj 0.05 Tc 10.5727 0 0 10.1 213.5 166.33 Tm (of )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0037 Tc 10.1 0 0 10.1 225.07 166.33 Tm (Pb. )Tj EMC /Suspect <>BDC 0.05 Tc 10.1224 0 0 10.1 241.87 166.33 Tm (Pb)Tj 0.561 0.565 0.549 rg 0 Tc 10.1 0 0 10.1 254.76 166.33 Tm (-)Tj EMC /Suspect <>BDC 0.263 0.267 0.255 rg 0.0208 Tc 0.862 0 Td (Ps )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 10.1194 0 0 10.1 275.9 166.33 Tm (at )Tj 0.0009 Tc 10.1 0 0 10.1 56.58 155.29 Tm (zero )Tj 0.0114 Tc 2.048 0 Td (time )Tj 0.0094 Tc 2.092 0 Td (was )Tj 0.0224 Tc 1.845 0 Td (assumed )Tj 0.0333 Tc 3.952 0 Td (to )Tj 0.05 Tc 10.1186 0 0 10.1 167.51 155.29 Tm (rep)Tj 0.086 0.086 0.078 rg 0 Tc 10.1 0 0 10.1 181.91 155.29 Tm (r)Tj 0.263 0.267 0.255 rg 0.0147 Tc 0.323 0 Td (esent )Tj 0.009 Tc 2.48 0 Td (the )Tj 0.0233 Tc 1.525 0 Td (pressu)Tj 0.086 0.086 0.078 rg 0 Tc 2.706 0 Td (r)Tj 0.263 0.267 0.255 rg 0.323 0 Td (e )Tj 0.05 Tc 10.2128 0 0 10.1 263.42 155.29 Tm (drop )Tj 0.086 0.086 0.078 rg 0 Tc 10.1 0 0 10.1 56.56 144.25 Tm (i)Tj 0.263 0.267 0.255 rg 0.197 0 Td (n )Tj 0.329 0.333 0.322 rg 0.009 Tc 0.997 0 Td (the )Tj 0.263 0.267 0.255 rg 0.0147 Tc 1.655 0 Td (airways )Tj 0.0311 Tc 3.612 0 Td (during )Tj 0.0328 Tc 3.192 0 Td (the )Tj 0.0433 Tc 1.655 0 Td (constant )Tj -0.0151 Tc 4.039 0 Td (flow )Tj -0.0248 Tc 2.173 0 Td ([5, )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 9.555 0 0 10.1 249.27 144.25 Tm (10]. )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 10.2656 0 0 10.1 267.27 144.25 Tm (The )Tj 0.0307 Tc 10.1 0 0 10.1 56.06 133.21 Tm (control )Tj 0.004 Tc 3.287 0 Td (values )Tj 0.05 Tc 11.6856 0 0 10.1 117.49 133.21 Tm (of )Tj 0.0212 Tc 10.1 0 0 10.1 129.55 133.21 Tm (Rsaw )Tj 0.0376 Tc 2.514 0 Td (are )Tj 0.329 0.333 0.322 rg 0.0157 Tc 1.517 0 Td (sometimes )Tj 0.0392 Tc 4.61 0 Td (so )Tj 0.263 0.267 0.255 rg -0.0052 Tc 1.193 0 Td (low )Tj 0.05 Tc 10.215 0 0 10.1 246.7 133.21 Tm (that )Tj -0.0023 Tc 10.1 0 0 10.1 266.38 133.21 Tm (they )Tj 0.0322 Tc -20.776 -1.094 Td (cannot )Tj 0.0171 Tc 3.195 0 Td (be )Tj 0.0173 Tc 1.328 0 Td (measured )Tj 0.0207 Tc 4.317 0 Td (accurately )Tj 0.329 0.333 0.322 rg -0.035 Tc 9.3585 0 0 10.1 192.37 122.16 Tm (\(2])Tj 0.18 0.184 0.169 rg 0 Tc 10.1 0 0 10.1 203.31 122.16 Tm (. )Tj 0.263 0.267 0.255 rg 0.05 Tc 10.2656 0 0 10.1 65.67 111.12 Tm (The )Tj 0.0049 Tc 10.1 0 0 10.1 88.21 111.12 Tm (following )Tj 0.0262 Tc 4.468 0 Td (calculations )Tj 0.004 Tc 5.617 0 Td (were )Tj 0.0409 Tc 2.518 0 Td (made )Tj 0.0271 Tc 2.843 0 Td (from )Tj 0.009 Tc 2.67 0 Td (the )Tj 0.0281 Tc -21.299 -1.093 Td (data: )Tj /T1_0 1 Tf 0 Tc 9.8 0 0 9.8 440.52 746.17 Tm (Q )Tj /T1_1 1 Tf 10.8 0 0 10.8 464.27 746.17 Tm (1 )Tj 0.05 Tc 11.8357 0 0 10.8 475.66 746.17 Tm (ml/s )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0 Tc 9.8 0 0 9.8 358.94 611.76 Tm (0 )Tj EMC ET BT /T1_0 1 Tf 9.4 0 0 9.4 382.74 611.76 Tm [(1 )-1589(2 )]TJ /T1_1 1 Tf 9.6 0 0 9.6 429.01 611.29 Tm (3 )Tj 10 0 0 10 452.12 611.29 Tm (4 )Tj /T1_0 1 Tf 8.6 0 0 8.6 482.36 610.8 Tm (t )Tj /T1_1 1 Tf 10.5 0 0 10.5 488.01 595.92 Tm (s )Tj 9.7 0 0 9.7 312.97 544.56 Tm (p )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 8.5532 0 0 10.8 318.64 532.56 Tm (cmH)Tj 0 Tc 10.8 0 0 10.8 335.94 527.76 Tm (2)Tj 0.529 0.444 Td (0 )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 11.5499 0 0 10.8 324.56 517.68 Tm (12.5 )Tj ET BT /Suspect <>BDC 0.18 0.184 0.169 rg /T1_0 1 Tf 0 Tc 17.8 0 0 17.8 360.68 512.89 Tm (\225 )Tj EMC /Suspect <>BDC 0.263 0.267 0.255 rg /T1_1 1 Tf 0.0204 Tc 9.5 0 0 9.5 376.76 517.68 Tm (Pb )Tj EMC /Suspect <>BDC -0.035 Tc 10.206 0 0 10.8 324.61 499.44 Tm (10 )Tj EMC ET BT /T1_1 1 Tf 0.05 Tc 11.589 0 0 10.7 330.12 478.81 Tm (7.5 )Tj 0.329 0.333 0.322 rg 0 Tc 10.7 0 0 10.7 329.61 449.05 Tm (5 )Tj 0.263 0.267 0.255 rg /T1_0 1 Tf 8.8 0 0 8.8 487.99 419.28 Tm (r )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 13 0 0 13 499.61 417.37 Tm (= )Tj EMC /Suspect <>BDC 0.05 Tc 11.7547 0 0 10.8 511.08 418.81 Tm (0.96 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 9.1 0 0 9.1 417.06 410.16 Tm (T )Tj ET BT /Suspect <>BDC 0.18 0.184 0.169 rg /T1_1 1 Tf 12.3 0 0 12.3 408.76 402.49 Tm (\225 )Tj EMC ET BT 0.329 0.333 0.322 rg /T1_1 1 Tf 0.05 Tc 11.9 0 0 10.7 329.21 395.28 Tm (2.5 )Tj 0.263 0.267 0.255 rg /T1_0 1 Tf 0 Tc 30.4 0 0 30.4 410.89 381.37 Tm (\\ )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 10.8 0 0 10.8 357.97 351.12 Tm (0 )Tj EMC ET BT 0.329 0.333 0.322 rg /T1_1 1 Tf 10.7 0 0 10.7 405.23 350.65 Tm (1 )Tj 0.263 0.267 0.255 rg 10.8 0 0 10.8 452.1 350.65 Tm (2 )Tj /T1_0 1 Tf 8.9 0 0 8.9 481.88 350.16 Tm (t )Tj /T1_1 1 Tf 10.8 0 0 10.8 493.29 340.56 Tm (s )Tj 9.8 0 0 9.8 339.28 268.09 Tm (T )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 12.2855 0 0 10.5 392.03 268.09 Tm (0.9 )Tj EMC ET BT /T1_1 1 Tf 0 Tc 10.6 0 0 10.6 433.77 267.12 Tm (s )Tj -0.035 Tc 10.4511 0 0 10.8 339.79 249.85 Tm (Rsaw )Tj 0.05 Tc 11.4608 0 0 10.8 392.11 248.41 Tm (4.25 )Tj -0.035 Tc 8.5532 0 0 10.8 433.36 247.93 Tm (cmH)Tj 0 Tc 10.8 0 0 10.8 451.14 243.13 Tm (2)Tj 0.05 Tc 12.1524 0 0 10.8 456.83 247.93 Tm (0/ml/s )Tj 11.1832 0 0 10.8 339.31 230.65 Tm (Rcoll )Tj 0 Tc 9.8 0 0 9.8 391.99 229.69 Tm (8 )Tj -0.035 Tc 8.5532 0 0 10.8 433.36 228.25 Tm (cmH)Tj 0 Tc 10.8 0 0 10.8 451.14 223.93 Tm (2)Tj 0.05 Tc 12.1524 0 0 10.8 456.83 228.25 Tm (0/ml/s )Tj -0.035 Tc 10.0962 0 0 10.8 339.26 210.97 Tm (Cs )Tj ET BT /Suspect <>BDC 0.329 0.333 0.322 rg /T1_1 1 Tf 0.05 Tc 11.7164 0 0 10.8 392.04 210.01 Tm (0. )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_1 1 Tf -0.0254 Tc 10.8 0 0 10.8 404.27 210.01 Tm (112 )Tj -0.0226 Tc 2.655 -0.089 Td (ml/cmH)Tj 0 Tc 3.285 -0.444 Td (2)Tj 0.529 0.444 Td (0 )Tj -0.0207 Tc 8.3 0 0 8.3 308.6 189.85 Tm (Fig. )Tj -0.035 Tc 8.1006 0 0 8.3 324.9 189.85 Tm (I. )Tj 0.0178 Tc 8.3 0 0 8.3 338.36 189.85 Tm (Diagram )Tj 0.05 Tc 9.4598 0 0 8.3 370.95 189.85 Tm (of )Tj 0.329 0.333 0.322 rg 8.3101 0 0 8.3 380.56 189.85 Tm (an )Tj 0.263 0.267 0.255 rg 0.0081 Tc 8.3 0 0 8.3 391.59 189.85 Tm (example )Tj 0.329 0.333 0.322 rg 0.05 Tc 8.9033 0 0 8.3 422.32 189.85 Tm (of )Tj 0.263 0.267 0.255 rg 0.0173 Tc 8.3 0 0 8.3 431.98 189.85 Tm (measurement )Tj ET BT /Suspect <>BDC 0.329 0.333 0.322 rg /T1_1 1 Tf 0.0122 Tc 8.3 0 0 8.3 479.8959 189.85 Tm (\(do$ )Tj EMC ET BT /T1_1 1 Tf -0.035 Tc 8.2559 0 0 8.3 498.15 189.85 Tm (7\). )Tj 0.263 0.267 0.255 rg 0.0414 Tc 8.3 0 0 8.3 508.73 189.85 Tm (The )Tj 0.0277 Tc 1.972 0 Td (top )Tj -0.0036 Tc -26.078 -1.041 Td (panel )Tj 0.329 0.333 0.322 rg 0.003 Tc 2.471 0 Td (shows )Tj 0.263 0.267 0.255 rg -0.0016 Tc 2.961 0 Td (the )Tj 0.329 0.333 0.322 rg 0.0128 Tc 1.554 0 Td (decay )Tj 0.05 Tc 8.9033 0 0 8.3 389.68 181.21 Tm (of )Tj ET BT /Suspect <>BDC 0.263 0.267 0.255 rg /T1_1 1 Tf 8.362 0 0 8.3 399.8 181.21 Tm (Pb )Tj EMC ET BT 0.329 0.333 0.322 rg /T1_1 1 Tf -0.0262 Tc 8.3 0 0 8.3 412.31 181.21 Tm (when )Tj -0.035 Tc 8.2465 0 0 8.3 432.87 181.21 Tm (flow )Tj 0.263 0.267 0.255 rg -0.0137 Tc 8.3 0 0 8.3 450.65 181.21 Tm (is )Tj 0.329 0.333 0.322 rg 0.0194 Tc 0.977 0 Td (stopped. )Tj 0.263 0.267 0.255 rg /T1_0 1 Tf 0 Tc 9.2 0 0 9.2 490.93 181.21 Tm (Q )Tj /T1_1 1 Tf -0.035 Tc 7.8068 0 0 8.3 500.1 181.21 Tm (is )Tj 0.0273 Tc 8.3 0 0 8.3 508.3 181.21 Tm (the )Tj -0.0195 Tc 1.611 0 Td (flow )Tj 0.329 0.333 0.322 rg 0.0004 Tc -25.665 -1.099 Td (before )Tj 0.263 0.267 0.255 rg 0.0314 Tc 2.76 0 Td (stop)Tj 0.431 0.435 0.423 rg 0 Tc 1.787 0 Td (. )Tj 0.329 0.333 0.322 rg 0.05 Tc 9.4297 0 0 8.3 350.77 172.09 Tm ('t' )Tj 0.263 0.267 0.255 rg -0.0137 Tc 8.3 0 0 8.3 359.93 172.09 Tm (is )Tj 0.007 Tc 0.931 0 Td (time )Tj -0.035 Tc 8.1281 0 0 8.3 384.86 172.09 Tm (\(s\). )Tj 0.0414 Tc 8.3 0 0 8.3 397.37 172.09 Tm (The )Tj 0.0013 Tc 1.914 0 Td (middle )Tj -0.0036 Tc 3.069 0 Td (panel )Tj 0.003 Tc 2.413 0 Td (shows )Tj -0.0016 Tc 2.846 0 Td (the )Tj -0.012 Tc 1.504 0 Td (values )Tj 0.05 Tc 8.9033 0 0 8.3 517.84 172.09 Tm (of )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 8.362 0 0 8.3 527 172.09 Tm (Pb )Tj EMC /Suspect <>BDC 0.329 0.333 0.322 rg /T1_0 1 Tf 0 Tc 8.2 0 0 8.2 308.02 162.97 Tm (\()Tj 0.18 0.184 0.169 rg 0.416 0 Td (e)Tj 0.329 0.333 0.322 rg 0.872 0 Td (\) )Tj EMC ET BT 0.263 0.267 0.255 rg /T1_1 1 Tf 0.0429 Tc 8.3 0 0 8.3 326.32 162.97 Tm (at )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.007 Tc 8.3 0 0 8.3 337.8404 162.97 Tm (0.2 )Tj EMC ET BT 0.329 0.333 0.322 rg /T1_1 1 Tf 0 Tc 8.3 0 0 8.3 353.1622 162.97 Tm (s )Tj 0.263 0.267 0.255 rg 0.0131 Tc 0.989 0 Td (intervals )Tj 0.0118 Tc 4.163 0 Td (during )Tj -0.0016 Tc 3.361 0 Td (the )Tj -0.0105 Tc 1.786 0 Td (decay: )Tj -0.0016 Tc 3.304 0 Td (the )Tj 0.0047 Tc 1.854 0 Td (pressure )Tj -0.009 Tc 3.923 0 Td (in )Tj 0.0273 Tc 1.452 0 Td (the )Tj 0.0153 Tc -26.263 -1.041 Td (obstructed )Tj 0.329 0.333 0.322 rg 0.0084 Tc 4.853 0 Td (segment )Tj 0.263 0.267 0.255 rg 0.05 Tc 8.9033 0 0 8.3 381.04 154.33 Tm (of )Tj 0.329 0.333 0.322 rg -0.0016 Tc 8.3 0 0 8.3 393.1 154.33 Tm (the )Tj 0.263 0.267 0.255 rg 0.0103 Tc 1.787 0 Td (lung )Tj 0.0225 Tc 2.381 0 Td (prior )Tj 0.035 Tc 2.599 0 Td (to )Tj 0.329 0.333 0.322 rg 0.0314 Tc 1.376 0 Td (stop )Tj 0.263 0.267 0.255 rg -0.035 Tc 7.9717 0 0 8.3 479.91 154.33 Tm (flow )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0044 Tc 8.3 0 0 8.3 498.68 154.33 Tm (Ps )Tj EMC ET BT 0.329 0.333 0.322 rg /T1_0 1 Tf 0.05 Tc 9.4821 0 0 7.7 511.03 154.33 Tm (\(0\), )Tj 0.263 0.267 0.255 rg /T1_1 1 Tf -0.035 Tc 7.8068 0 0 8.3 531.3 154.33 Tm (is )Tj 0.329 0.333 0.322 rg 0.0089 Tc 8.3 0 0 8.3 307.6 145.21 Tm (calculated )Tj 0.0465 Tc 4.626 0 Td (as )Tj 0.263 0.267 0.255 rg 0.007 Tc 1.33 0 Td (described )Tj 0.329 0.333 0.322 rg -0.035 Tc 7.9356 0 0 8.3 394.02 145.21 Tm (in )Tj 0.0273 Tc 8.3 0 0 8.3 404.14 145.21 Tm (the )Tj 0.263 0.267 0.255 rg 0.0129 Tc 1.796 0 Td (protocol; )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 8.362 0 0 8.3 454.04 145.21 Tm (Pb)Tj 0.431 0.435 0.423 rg 0 Tc 8.3 0 0 8.3 464.54 145.21 Tm (-)Tj EMC /Suspect <>BDC 0.263 0.267 0.255 rg -0.0044 Tc 0.817 0 Td (Ps )Tj EMC ET BT 0.329 0.333 0.322 rg /T1_1 1 Tf 0.0429 Tc 8.3 0 0 8.3 483.2814 145.21 Tm (at )Tj -0.0104 Tc 1.277 0 Td (zero )Tj -0.0122 Tc 2.258 0 Td (time )Tj 0.263 0.267 0.255 rg -0.035 Tc 7.8068 0 0 8.3 531.3 145.21 Tm (is )Tj 0.329 0.333 0.322 rg -0.003 Tc 8.3 0 0 8.3 308.08 136.09 Tm (assumed )Tj 0.263 0.267 0.255 rg 0.035 Tc 3.94 0 Td (to )Tj 0.329 0.333 0.322 rg -0.0081 Tc 1.276 0 Td (be )Tj 0.263 0.267 0.255 rg 0.0273 Tc 1.327 0 Td (the )Tj 0.013 Tc 1.739 0 Td (pressure )Tj 0.0474 Tc 3.748 0 Td (drop )Tj -0.009 Tc 2.43 0 Td (in )Tj 0.0273 Tc 1.163 0 Td (the )Tj 0.0045 Tc 1.67 0 Td (airways )Tj 0.0118 Tc 3.586 0 Td (during )Tj 0.329 0.333 0.322 rg 0.0129 Tc 3.065 0 Td (cons)Tj 0.18 0.184 0.169 rg 0.0415 Tc 1.916 0 Td (tant )Tj 0.263 0.267 0.255 rg -0.035 Tc 8.0767 0 0 8.3 308.07 127.44 Tm (flow. )Tj 0.329 0.333 0.322 rg 0.05 Tc 8.7427 0 0 8.3 326.78 127.44 Tm ('r' )Tj 0.263 0.267 0.255 rg -0.035 Tc 7.8068 0 0 8.3 336.42 127.44 Tm (is )Tj 0.0273 Tc 8.3 0 0 8.3 343.66 127.44 Tm (the )Tj -0.0001 Tc 1.563 0 Td (regression )Tj -0.0143 Tc 4.387 0 Td (coefficient )Tj 0.329 0.333 0.322 rg 0.05 Tc 8.9033 0 0 8.3 429.52 127.44 Tm (of )Tj -0.0016 Tc 8.3 0 0 8.3 439.18 127.44 Tm (the )Tj 0.263 0.267 0.255 rg 0.006 Tc 1.439 0 Td (decrease )Tj 0.329 0.333 0.322 rg 0.05 Tc 9.4598 0 0 8.3 481.83 127.44 Tm (of )Tj 0.263 0.267 0.255 rg 0.0057 Tc 8.3 0 0 8.3 491.05 127.44 Tm (pressure; )Tj 0.05 Tc 9.1796 0 0 8.3 523.6 127.44 Tm (Tis )Tj -0.0016 Tc 8.3 0 0 8.3 308.14 118.32 Tm (the )Tj 0.329 0.333 0.322 rg -0.0122 Tc 1.677 0 Td (time )Tj 0.023 Tc 2.075 0 Td (constant )Tj 0.05 Tc 8.9033 0 0 8.3 371.92 118.32 Tm (of )Tj 0.0202 Tc 8.3 0 0 8.3 381.52 118.32 Tm (collateral )Tj 0.0024 Tc 4.287 0 Td (ventilation; )Tj 0.263 0.267 0.255 rg 0.0126 Tc 5.029 0 Td (Rsaw )Tj 0.329 0.333 0.322 rg -0.035 Tc 7.8068 0 0 8.3 480.9 118.32 Tm (is )Tj 0.263 0.267 0.255 rg -0.0016 Tc 8.3 0 0 8.3 489.1 118.32 Tm (the )Tj 0.329 0.333 0.322 rg 0.0183 Tc 1.554 0 Td (computed )Tj 0.263 0.267 0.255 rg -0.0005 Tc -23.355 -1.099 Td (resistance )Tj 0.329 0.333 0.322 rg 0.05 Tc 8.9033 0 0 8.3 345.04 109.2 Tm (of )Tj 0.263 0.267 0.255 rg 0.015 Tc 8.3 0 0 8.3 355.56 109.2 Tm (small )Tj 0.329 0.333 0.322 rg 0.0045 Tc 2.723 0 Td (airways )Tj -0.009 Tc 3.645 0 Td (in )Tj 0.263 0.267 0.255 rg 0.0273 Tc 1.278 0 Td (the )Tj 0.329 0.333 0.322 rg 0.0045 Tc 1.723 0 Td (segment, )Tj 0.263 0.267 0.255 rg -0.0052 Tc 4.173 0 Td (Rcoll )Tj 0.0273 Tc 2.663 0 Td (the )Tj 0.329 0.333 0.322 rg 0.0073 Tc 1.728 0 Td (collateral )Tj -0.0005 Tc -23.645 -1.04 Td (resistance )Tj 0.05 Tc 8.4599 0 0 8.3 343.59 100.57 Tm (and )Tj 0.263 0.267 0.255 rg 0.0076 Tc 8.3 0 0 8.3 358.96 100.57 Tm (Cs )Tj -0.0016 Tc 1.453 0 Td (the )Tj 0.329 0.333 0.322 rg -0.0075 Tc 1.495 0 Td (effective )Tj 0.0113 Tc 3.702 0 Td (compliance )Tj 0.05 Tc 8.9033 0 0 8.3 455.92 100.57 Tm (of )Tj 0.263 0.267 0.255 rg 0.0273 Tc 8.3 0 0 8.3 465.58 100.57 Tm (the )Tj -0.0037 Tc 1.607 0 Td (segment. )Tj ET endstream endobj 3 0 obj <>stream jP ftypjp2 jp2 jpxbjpx rreq@ --jp2hihdrcolr1cjp2cOQ/R \#B@HHPHHPHHPHHP((( ߇F8L /bM V?5 UE^,H,Su#vkqxO%!%d#\$$T$UloFzɵe*"Mk"#0xoP6ͼPdtYaӔ{7fǬ8}tcZ7go;.LfXvH9c[A񋠻.ZTe-{CΐwXn TCiPI-_? `t+Ph5*_z※_wߧ0;~d l JNsűs[+./rQAno7FdlFw[zwx^iޑ-Y>T ADǠeJC&phr?0y[P^҉{7mWˠ#K^ҲDF$VVbŤ:r~qшoGq aު{RϽRc֬ Q>>?<$ Jl+!)Ç_vh K u߂8 ,K$Ju:J"%rt 2X>̈rK?vǂMsy ҆V__9߽X_N F>x 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/T1_0 1 Tf 8.5533 0 0 7.8001 306.15 779.29 Tm (COL)Tj 0.169 0.173 0.165 rg 8.6322 0 0 7.8001 325.39 779.29 Tm (LATERAL )Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg 8.5679 0 0 7.8001 371.48 779.29 Tm (RESISTANCE )Tj EMC ET BT /T1_0 1 Tf 0.0017 Tc 9.7 0 0 9.7 517.38 779.29 Tm (219 )Tj 0.624 0.628 0.612 rg 0 Tc -47.708 -2.474 Td (-)Tj 0.263 0.263 0.255 rg 0.0299 Tc 1.247 0 Td (resistance )Tj 0.05 Tc 10.4772 0 0 9.7 113.73 755.29 Tm (to )Tj 0.035 Tc 9.7 0 0 9.7 128.07 755.29 Tm (collateral )Tj 0.0396 Tc 4.758 0 Td (ventilat)Tj 0.094 0.094 0.086 rg 0 Tc 3.26 0 Td (i)Tj 0.263 0.263 0.255 rg 0.05 Tc 10.2564 0 0 9.7 208.22 755.29 Tm (on )Tj 0.0042 Tc 9.7 0 0 9.7 226.52 755.29 Tm (Rcoll )Tj 0 Tc 12.7 0 0 12.7 250.02 755.29 Tm (= )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0177 Tc 9.7 0 0 9.7 258.68 755.29 Tm (PsjV; )Tj EMC ET BT 0.435 0.435 0.428 rg /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 65.6597 744.7267 Tm (a)Tj 0.263 0.263 0.255 rg 0.0291 Tc 0.546 0 Td (irway )Tj 0.353 0.357 0.349 rg 0.0189 Tc 3.026 0 Td (resistance )Tj 0.0346 Tc 4.701 0 Td (within )Tj 0.05 Tc 9.8357 0 0 9.7 178.54 744.73 Tm (the )Tj 9.7221 0 0 9.7 196.23 744.73 Tm (obstructed )Tj 0.435 0.435 0.428 rg 0.0147 Tc 9.7 0 0 9.7 246.58 744.73 Tm (seg)Tj 0.263 0.263 0.255 rg 0.0451 Tc 1.348 0 Td (ment )Tj 0.353 0.357 0.349 rg 0.05 Tc 10.7895 0 0 9.7 54.19 733.68 Tm (Rsaw= )Tj ET BT /Suspect <>BDC 0.263 0.263 0.255 rg /T1_0 1 Tf 0.048 Tc 9.7 0 0 9.7 88.76 733.68 Tm (Pb)Tj 0.522 0.525 0.518 rg 0 Tc 1.279 0 Td (-)Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg 0.05 Tc 9.7994 0 0 9.7 109.4 733.68 Tm (Ps)Tj 0.522 0.525 0.518 rg -0.035 Tc 9.5261 0 0 9.7 119.52 733.68 Tm (/v\267 )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf 0.05 Tc 10.2656 0 0 9.7 132.87 733.68 Tm (The )Tj 0.353 0.357 0.349 rg 0.0292 Tc 9.7 0 0 9.7 153.58 733.68 Tm (theoretical )Tj 0.263 0.263 0.255 rg 0.0258 Tc 4.991 0 Td (definjtion )Tj 0.353 0.357 0.349 rg 0.05 Tc 11.6856 0 0 9.7 245.65 733.68 Tm (of )Tj 0.263 0.263 0.255 rg 0.0413 Tc 9.7 0 0 9.7 258.2 733.68 Tm (Rcoll )Tj -0.035 Tc 9.3682 0 0 9.7 55.12 722.65 Tm (is )Tj 0 Tc 9.7 0 0 9.7 64.76 722.65 Tm (R)Tj 0.435 0.435 0.428 rg 0.05 Tc 9.867 0 0 9.7 71.42 722.65 Tm (co)Tj 0.263 0.263 0.255 rg -0.035 Tc 8.5757 0 0 9.7 81.53 722.65 Tm (ll )Tj ET BT /Suspect <>BDC 0.522 0.525 0.518 rg /T1_0 1 Tf 0.05 Tc 10.6607 0 0 9.7 88.27 722.65 Tm (={)Tj 0.263 0.263 0.255 rg 0 Tc 9.7 0 0 9.7 100.28 722.65 Tm (P)Tj 0.435 0.435 0.428 rg 0.05 Tc 16.7125 0 0 9.7 105.36 722.65 Tm (s-)Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg 0.0161 Tc 9.7 0 0 9.7 120.44 722.65 Tm (Palv\)jVcoll)Tj 0.435 0.435 0.428 rg 0 Tc 4.838 0 Td (, )Tj EMC /Suspect <>BDC 0.353 0.357 0.349 rg 0.0051 Tc 0.559 0 Td (wht:re )Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg 0.0069 Tc 2.966 0 Td (Palv )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf -0.035 Tc 9.3682 0 0 9.7 222.64 722.65 Tm (is )Tj 0.0345 Tc 9.7 0 0 9.7 231.82 722.65 Tm (the )Tj 0.0441 Tc 1.575 0 Td (alveolar )Tj 0.263 0.263 0.255 rg 0.0345 Tc -19.832 -1.089 Td (pre)Tj 0.435 0.435 0.428 rg 0.0169 Tc 1.37 0 Td (ssu)Tj 0.263 0.263 0.255 rg 0.0161 Tc 1.399 0 Td (re )Tj 0.353 0.357 0.349 rg 0.05 Tc 10.5727 0 0 9.7 92.54 712.09 Tm (of )Tj 0.263 0.263 0.255 rg 0.0345 Tc 9.7 0 0 9.7 104.14 712.09 Tm (the )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.7687 0 0 9.7 119.38 712.09 Tm (surrounding )Tj 0.263 0.263 0.255 rg 0.0396 Tc 9.7 0 0 9.7 174.64 712.09 Tm (lung)Tj 0.435 0.435 0.428 rg 0 Tc 1.923 0 Td (, )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.8289 0 0 9.7 199.21 712.09 Tm (but )Tj 0.263 0.263 0.255 rg -0.0186 Tc 9.7 0 0 9.7 215.92 712.09 Tm (in )Tj 0.0378 Tc 1.098 0 Td (practice )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0234 Tc 9.7 0 0 9.7 262.9941 712.09 Tm (Palv )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf -0.0066 Tc 9.7 0 0 9.7 54.6381 701.0514 Tm (is )Tj 0.0387 Tc 1.384 0 Td (assumed )Tj 0.05 Tc 9.8951 0 0 9.7 111.82 701.05 Tm (to )Tj 0.0068 Tc 9.7 0 0 9.7 127.69 701.05 Tm (be )Tj 0.0458 Tc 1.671 0 Td (equivalent )Tj 0.263 0.263 0.255 rg 0.05 Tc 9.8951 0 0 9.7 195.82 701.05 Tm (to )Tj 0.353 0.357 0.349 rg 0.0425 Tc 9.7 0 0 9.7 211.1 701.05 Tm (airway )Tj 0.0441 Tc 3.712 0 Td (opening )Tj 0.0346 Tc -19.833 -1.139 Td (pressure )Tj 0.435 0.435 0.428 rg 0.0271 Tc 3.847 0 Td (\(o)Tj 0.263 0.263 0.255 rg 0 Tc 0.951 0 Td (r )Tj 0.435 0.435 0.428 rg 0.585 0 Td (a)Tj 0.263 0.263 0.255 rg 0.0407 Tc 0.602 0 Td (tmo)Tj 0.435 0.435 0.428 rg 0.027 Tc 1.67 0 Td (sp)Tj 0.263 0.263 0.255 rg 0.0216 Tc 1.003 0 Td (heric )Tj 0.353 0.357 0.349 rg 0.0346 Tc 2.328 0 Td (pressure )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0186 Tc 9.7 0 0 9.7 199.1205 690.0017 Tm (in )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.7004 0 0 9.7 209.66 690 Tm (apnoea )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 10.1194 0 0 9.7 242.78 690 Tm (at )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf 10.7104 0 0 9.7 253.87 690 Tm (FR)Tj 0.435 0.435 0.428 rg 0.0049 Tc 9.7 0 0 9.7 268.22 690 Tm (C\). )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.8034 0 0 9.7 54.16 678.97 Tm (This )Tj 0.0453 Tc 9.7 0 0 9.7 75.26 678.97 Tm (assumption )Tj -0.035 Tc 9.3682 0 0 9.7 126.64 678.97 Tm (is )Tj 0.0093 Tc 9.7 0 0 9.7 135.34 678.97 Tm (valid )Tj 0.263 0.263 0.255 rg -0.0186 Tc 2.369 0 Td (in )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.7237 0 0 9.7 168.39 678.97 Tm (control )Tj 0.0455 Tc 9.7 0 0 9.7 201.51 678.97 Tm (conditions )Tj 0.435 0.435 0.428 rg 0 Tc 4.795 0 Td (s)Tj 0.263 0.263 0.255 rg 0.0119 Tc 0.452 0 Td (ince )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 10.5 0 0 10.5 271.63 678.97 Tm (P)Tj 0.435 0.435 0.428 rg 0.539 0 Td (s )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf 0.0252 Tc 9.7 0 0 9.7 54.15 668.41 Tm (decayed )Tj 0.353 0.357 0.349 rg 0.0171 Tc 4.065 0 Td (to )Tj 0.05 Tc 9.7414 0 0 9.7 105.98 668.41 Tm (atmospheric )Tj 0.263 0.263 0.255 rg 0.0346 Tc 9.7 0 0 9.7 163.21 668.41 Tm (pressure)Tj 0.435 0.435 0.428 rg 0 Tc 3.591 0 Td (. )Tj ET BT /Suspect <>BDC 0.169 0.173 0.165 rg /T1_1 1 Tf 0.05 Tc 13.1112 0 0 10 205.56 668.41 Tm (If )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf 0.0409 Tc 9.7 0 0 9.7 216.39 668.41 Tm (constriction )Tj 0.05 Tc 11.1292 0 0 9.7 271.57 668.41 Tm (or )Tj 0.0338 Tc 9.7 0 0 9.7 54.15 657.36 Tm (closure )Tj 0.0243 Tc 3.623 0 Td (between )Tj 0.0191 Tc 3.997 0 Td (alveoli )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0173 Tc 9.7 0 0 9.7 160.8015 657.36 Tm (und )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.7398 0 0 9.7 181.34 657.36 Tm (airway )Tj 9.7383 0 0 9.7 214.95 657.36 Tm (opening )Tj 0.0367 Tc 9.7 0 0 9.7 253.83 657.36 Tm (occurs )Tj 0.263 0.263 0.255 rg 0.05 Tc 9.7525 0 0 9.7 54.14 646.33 Tm (after )Tj 0.0222 Tc 9.7 0 0 9.7 79.59 646.33 Tm (challenge, )Tj 0.0345 Tc 4.956 0 Td (the )Tj 0.0453 Tc 1.872 0 Td (assumption )Tj -0.0048 Tc 5.601 0 Td (will )Tj 0.0446 Tc 2.178 0 Td (underestimate )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.7977 0 0 9.7 54.2 635.29 Tm (Palv )Tj EMC ET BT /T1_0 1 Tf 10.3398 0 0 9.7 80.05 635.29 Tm (and )Tj 0.353 0.357 0.349 rg 0.0374 Tc 9.7 0 0 9.7 104.07 635.29 Tm (overestimate )Tj 0.263 0.263 0.255 rg 0.0271 Tc 6.29 0 Td (Rcoll; )Tj 0.0289 Tc 3.414 0 Td (Rcoll )Tj 0.0444 Tc 3.121 0 Td (would )Tj 0.05 Tc 9.7663 0 0 9.7 262.54 635.29 Tm (then )Tj 0.0373 Tc 9.7 0 0 9.7 54.71 624.24 Tm (represent )Tj 0.05 Tc 9.8357 0 0 9.7 96.94 624.24 Tm (the )Tj 0.0456 Tc 9.7 0 0 9.7 113.62 624.24 Tm (sum )Tj 0.353 0.357 0.349 rg 0.05 Tc 11.1292 0 0 9.7 134.77 624.24 Tm (of )Tj 0.035 Tc 9.7 0 0 9.7 147.27 624.24 Tm (collateral )Tj 0.263 0.263 0.255 rg -0.0187 Tc 4.511 0 Td (resi)Tj 0.435 0.435 0.428 rg 0 Tc 1.471 0 Td (s)Tj 0.263 0.263 0.255 rg 0.0432 Tc 0.458 0 Td (tance )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.7132 0 0 9.7 235.58 624.24 Tm (and )Tj 11.1292 0 0 9.7 255.25 624.24 Tm (of )Tj 0.263 0.263 0.255 rg 0.0171 Tc 9.7 0 0 9.7 268.3 624.24 Tm (th)Tj 0.435 0.435 0.428 rg 0 Tc 0.833 0 Td (e )Tj 0.263 0.263 0.255 rg 0.0227 Tc -22.902 -1.089 Td (resistances )Tj 0.05 Tc 10.5727 0 0 9.7 105.98 613.68 Tm (of )Tj 0.0345 Tc 9.7 0 0 9.7 121.9 613.68 Tm (the )Tj 0.353 0.357 0.349 rg 0.0418 Tc 2.081 0 Td (pathways )Tj 0.0243 Tc 4.849 0 Td (between )Tj 0.0109 Tc 4.244 0 Td (alveoli )Tj 0.05 Tc 10.0265 0 0 9.7 264.86 613.68 Tm (and )Tj 0.263 0.263 0.255 rg 0.0425 Tc 9.7 0 0 9.7 53.66 602.65 Tm (airway )Tj 0.0303 Tc 3.811 0 Td (opening. )Tj 0.05 Tc 10.4937 0 0 9.7 134.79 602.65 Tm (Th)Tj 0.435 0.435 0.428 rg 0 Tc 9.7 0 0 9.7 146.78 602.65 Tm (e )Tj 0.05 Tc 9.867 0 0 9.7 159.26 602.65 Tm (co)Tj 0.263 0.263 0.255 rg 9.7364 0 0 9.7 169.43 602.65 Tm (ntribution )Tj 0.353 0.357 0.349 rg 11.6856 0 0 9.7 220.21 602.65 Tm (of )Tj 0.0345 Tc 9.7 0 0 9.7 237.58 602.65 Tm (the )Tj 0.263 0.263 0.255 rg 0.05 Tc 9.8742 0 0 9.7 258.64 602.65 Tm (latter )Tj 0.0276 Tc 9.7 0 0 9.7 53.75 591.61 Tm (resistances )Tj -0.0066 Tc 4.991 0 Td (is )Tj 0.353 0.357 0.349 rg 0.0346 Tc 0.984 0 Td (small )Tj 0.435 0.435 0.428 rg -0.035 Tc 9.5089 0 0 9.7 137.63 591.61 Tm (si)Tj 0.263 0.263 0.255 rg 0.0014 Tc 9.7 0 0 9.7 144.47 591.61 Tm (nce )Tj 0.353 0.357 0.349 rg 0.0379 Tc 1.83 0 Td (their )Tj 0.0152 Tc 2.375 0 Td (values )Tj 0 Tc 3.01 0 Td (a)Tj 0.169 0.173 0.165 rg 0.554 0 Td (r)Tj 0.353 0.357 0.349 rg 0.337 0 Td (e )Tj 0.0297 Tc 0.84 0 Td (far )Tj 0.263 0.263 0.255 rg 0.0172 Tc 1.587 0 Td (lower; )Tj 0.522 0.525 0.518 rg 0 Tc -19.896 -1.139 Td (-)Tj 0.263 0.263 0.255 rg 0.0363 Tc 0.851 0 Td (time )Tj 0.05 Tc 9.839 0 0 9.7 82.46 580.56 Tm (constant )Tj 0.026 Tc 9.7 0 0 9.7 121.33 580.56 Tm (for )Tj 0.0405 Tc 1.487 0 Td (collateral )Tj 0.0386 Tc 4.312 0 Td (ventilation )Tj 0.0123 Tc 4.939 0 Td (\(Tcoll\): )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0341 Tc 9.7 0 0 9.7 258.6432 580.56 Tm (Tcoll )Tj EMC ET BT /T1_0 1 Tf -0.0066 Tc 9.7 0 0 9.7 53.6822 569.5311 Tm (is )Tj 0.169 0.173 0.165 rg 0.0218 Tc 1.038 0 Td (defined )Tj 0.263 0.263 0.255 rg 0.05 Tc 9.9203 0 0 9.7 97.82 569.53 Tm (as )Tj 0.0345 Tc 9.7 0 0 9.7 110.38 569.53 Tm (the )Tj 0.0363 Tc 1.682 0 Td (time )Tj 0.05 Tc 9.7106 0 0 9.7 148.69 569.53 Tm (for )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0106 Tc 9.7 0 0 9.7 165.08 569.53 Tm (Ps )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.8951 0 0 9.7 178.06 569.53 Tm (to )Tj 0.0405 Tc 9.7 0 0 9.7 189.99 569.53 Tm (decrease )Tj 0.05 Tc 10.0608 0 0 9.7 229.32 569.53 Tm (63% )Tj 9.765 0 0 9.7 252.87 569.53 Tm (during )Tj 9.8357 0 0 9.7 53.74 558.97 Tm (the )Tj 0.0128 Tc 9.7 0 0 9.7 70.42 558.97 Tm (single )Tj 0.0407 Tc 2.825 0 Td (exponential )Tj 0.0334 Tc 5.444 0 Td (decrease )Tj 0.05 Tc 11.1292 0 0 9.7 189.49 558.97 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0475 Tc 9.7 0 0 9.7 202.04 558.97 Tm (Pb. )Tj EMC ET BT /T1_0 1 Tf 0.023 Tc 9.7 0 0 9.7 219.6552 558.97 Tm (Since )Tj 0.05 Tc 9.8357 0 0 9.7 245.74 558.97 Tm (the )Tj 0.0198 Tc 9.7 0 0 9.7 262.54 558.97 Tm (time )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.839 0 0 9.7 53.66 547.92 Tm (constant )Tj 0.263 0.263 0.255 rg -0.0066 Tc 9.7 0 0 9.7 95.92 547.92 Tm (is )Tj 0.0406 Tc 1.286 0 Td (determjned )Tj -0.0007 Tc 5.553 0 Td (by )Tj 0.0345 Tc 1.679 0 Td (the )Tj 0.05 Tc 10.0479 0 0 9.7 197.3 547.92 Tm (product )Tj 9.7599 0 0 9.7 236.59 547.92 Tm (Rcoll )Tj 0 Tc 10.7 0 0 10.7 262.04 547.92 Tm (x )Tj 0.05 Tc 9.7471 0 0 9.7 269.66 547.92 Tm (Cs )Tj 0.353 0.357 0.349 rg 0.006 Tc 9.7 0 0 9.7 53.65 536.89 Tm (\(effective )Tj 0.05 Tc 10.0088 0 0 9.7 93.98 536.89 Tm (comp)Tj 0.169 0.173 0.165 rg -0.035 Tc 7.6229 0 0 9.7 118.5 536.89 Tm (li)Tj 0.353 0.357 0.349 rg 0.0373 Tc 9.7 0 0 9.7 123.26 536.89 Tm (ance )Tj 0.05 Tc 11.1292 0 0 9.7 145.33 536.89 Tm (of )Tj 0.0345 Tc 9.7 0 0 9.7 157.42 536.89 Tm (the )Tj 0.435 0.435 0.428 rg 0.0281 Tc 1.571 0 Td (segmen)Tj 0.263 0.263 0.255 rg 0 Tc 3.278 0 Td (t)Tj 0.435 0.435 0.428 rg 0.05 Tc 10.1613 0 0 9.7 206.82 536.89 Tm (\). )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf 0.0345 Tc 9.7 0 0 9.7 216.94 536.89 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0406 Tc 9.7 0 0 9.7 232.2272 536.89 Tm (compliance )Tj 0.263 0.263 0.255 rg 0.05 Tc 10.5727 0 0 9.7 53.66 526.33 Tm (of )Tj 9.8357 0 0 9.7 65.74 526.33 Tm (the )Tj 0.0457 Tc 9.7 0 0 9.7 81.99 526.33 Tm (obstructed )Tj 0.353 0.357 0.349 rg 0.024 Tc 4.993 0 Td (segme)Tj 0.169 0.173 0.165 rg 0.0181 Tc 2.686 0 Td (nt )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.7471 0 0 9.7 168.38 526.33 Tm (Cs )Tj 0.435 0.435 0.428 rg 0 Tc 12.1 0 0 12.1 180.9 526.33 Tm (= )Tj 0.263 0.263 0.255 rg 0.0464 Tc 9.7 0 0 9.7 189.04 526.33 Tm (Tcoll )Tj 0.435 0.435 0.428 rg /T1_1 1 Tf 0 Tc 9 0 0 9 213.59 526.33 Tm (x )Tj 0.263 0.263 0.255 rg /T1_0 1 Tf 0.0289 Tc 9.7 0 0 9.7 221.24 526.33 Tm (Rcoll )Tj 0.353 0.357 0.349 rg -0.035 Tc 9.4074 0 0 10.4 247.45 526.33 Tm ([9]. )Tj 0.263 0.263 0.255 rg 0.05 Tc 9.9724 0 0 9.7 63.34 515.29 Tm (As )Tj 0.0309 Tc 9.7 0 0 9.7 81.52 515.29 Tm (in )Tj 0.037 Tc 1.543 0 Td (previou)Tj 0.435 0.435 0.428 rg 0 Tc 3.3 0 Td (s )Tj 0.05 Tc 9.7286 0 0 9.7 138.58 515.29 Tm (st)Tj 0.263 0.263 0.255 rg 0.0207 Tc 9.7 0 0 9.7 146.4 515.29 Tm (udie)Tj 0.435 0.435 0.428 rg -0.0199 Tc 1.816 0 Td (s, )Tj 0.353 0.357 0.349 rg 0.0139 Tc 1.349 0 Td (wide )Tj 0.0413 Tc 2.721 0 Td (variations )Tj 0.05 Tc 11.6856 0 0 9.7 251.89 515.29 Tm (of )Tj 0.263 0.263 0.255 rg 0.0345 Tc 9.7 0 0 9.7 267.82 515.29 Tm (the )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.7237 0 0 9.7 53.19 504.25 Tm (control )Tj 0.263 0.263 0.255 rg 0.0388 Tc 9.7 0 0 9.7 87.82 504.25 Tm (valu)Tj 0.435 0.435 0.428 rg -0.0205 Tc 1.872 0 Td (es )Tj 0.353 0.357 0.349 rg 0.0143 Tc 1.246 0 Td (were )Tj 0.0303 Tc 2.367 0 Td (observed: )Tj 0.263 0.263 0.255 rg 0.0146 Tc 4.609 0 Td (this )Tj 0.0391 Tc 1.931 0 Td (range )Tj 0.0481 Tc 2.763 0 Td (depend)Tj 0.435 0.435 0.428 rg 0 Tc 3.162 0 Td (s )Tj 0.263 0.263 0.255 rg 0.05 Tc 10.2564 0 0 9.7 269.66 504.25 Tm (on )Tj 0.0345 Tc 9.7 0 0 9.7 53.74 493.21 Tm (the )Tj 0.05 Tc 10.1102 0 0 9.7 69.1 493.21 Tm (vo)Tj 0.094 0.094 0.086 rg 0 Tc 9.7 0 0 9.7 80.08 493.21 Tm (l)Tj 0.263 0.263 0.255 rg 0.031 Tc 0.305 0 Td (ume )Tj 0.05 Tc 11.1292 0 0 9.7 103.57 493.21 Tm (of )Tj 9.8357 0 0 9.7 115.18 493.21 Tm (the )Tj 0.0226 Tc 9.7 0 0 9.7 131.03 493.21 Tm (wedged )Tj 0.0296 Tc 3.549 0 Td (segment, )Tj 0.0345 Tc 4.169 0 Td (the )Tj 0.05 Tc 9.7733 0 0 9.7 221.26 493.21 Tm (volume )Tj 0.169 0.173 0.165 rg 11.1292 0 0 9.7 255.73 493.21 Tm (of )Tj 0.263 0.263 0.255 rg 0.0345 Tc 9.7 0 0 9.7 267.82 493.21 Tm (the )Tj 0.435 0.435 0.428 rg 0 Tc -22.132 -1.139 Td (s)Tj 0.263 0.263 0.255 rg 0.05 Tc 9.8112 0 0 9.7 57.6 482.16 Tm (urrounding )Tj 0.353 0.357 0.349 rg 0.0349 Tc 9.7 0 0 9.7 113.62 482.16 Tm (segment )Tj 0.263 0.263 0.255 rg 0.05 Tc 9.7132 0 0 9.7 156.86 482.16 Tm (and )Tj 0.0379 Tc 9.7 0 0 9.7 181.42 482.16 Tm (their )Tj 0.0365 Tc 2.871 0 Td (relationships )Tj 0.05 Tc 10.4772 0 0 9.7 271.65 482.16 Tm (to )Tj 0.353 0.357 0.349 rg 0.0304 Tc 9.7 0 0 9.7 53.77 471.61 Tm (pleura. )Tj 0.263 0.263 0.255 rg 0.048 Tc 3.356 0 Td (Therefore )Tj 0.353 0.357 0.349 rg 0.0466 Tc 4.707 0 Td (most )Tj 0.263 0.263 0.255 rg 0.0272 Tc 2.475 0 Td (results )Tj -0.0048 Tc 3.167 0 Td (will )Tj 0.0068 Tc 1.981 0 Td (be )Tj 0.0296 Tc 1.325 0 Td (expressed )Tj 0.05 Tc 9.9203 0 0 9.7 262.94 471.61 Tm (as )Tj 0 Tc 10.1 0 0 10.1 275.42 471.61 Tm (a )Tj 0.0318 Tc 9.7 0 0 9.7 53.77 460.56 Tm (percentage )Tj 0.353 0.357 0.349 rg 0.05 Tc 11.1292 0 0 9.7 103.09 460.56 Tm (of )Tj 0.263 0.263 0.255 rg 0.0345 Tc 9.7 0 0 9.7 116.14 460.56 Tm (the )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.7237 0 0 9.7 132.87 460.56 Tm (control )Tj 0.263 0.263 0.255 rg 0.035 Tc 9.7 0 0 9.7 167.5 460.56 Tm (values)Tj 0.435 0.435 0.428 rg 0 Tc 2.758 0 Td (, )Tj 0.263 0.263 0.255 rg 0.05 Tc 10.4772 0 0 9.7 200.61 460.56 Tm (to )Tj 9.7028 0 0 9.7 213.51 460.56 Tm (compensate )Tj 0.026 Tc 9.7 0 0 9.7 268.21 460.56 Tm (for )Tj 0.0379 Tc -22.11 -1.137 Td (their )Tj 0.0258 Tc 2.712 0 Td (fluctuations. )Tj 0.05 Tc 10.2656 0 0 9.7 138.63 449.53 Tm (The )Tj 0.353 0.357 0.349 rg 0.0437 Tc 9.7 0 0 9.7 161.62 449.53 Tm (statistica)Tj 0.169 0.173 0.165 rg 0 Tc 3.915 0 Td (l )Tj 0.263 0.263 0.255 rg 0.018 Tc 0.934 0 Td (significance )Tj 0.0417 Tc 5.754 0 Td (was )Tj 0.0097 Tc -21.725 -1.138 Td (tested )Tj 0.353 0.357 0.349 rg -0.0007 Tc 3.022 0 Td (by )Tj -0.035 Tc 9.5618 0 0 9.7 98.88 438.49 Tm (us)Tj 0.169 0.173 0.165 rg 0 Tc 9.7 0 0 9.7 107.44 438.49 Tm (i)Tj 0.353 0.357 0.349 rg 0.0425 Tc 0.304 0 Td (ng )Tj 0 Tc 11.4 0 0 11.4 125.16 438.49 Tm (a )Tj 0.0337 Tc 9.7 0 0 9.7 135.34 438.49 Tm (variance )Tj 0.0256 Tc 4.148 0 Td (analysis. )Tj 0.263 0.263 0.255 rg 0.05 Tc 9.9723 0 0 9.7 216.39 438.49 Tm (The )Tj 0.435 0.435 0.428 rg 0.0482 Tc 9.7 0 0 9.7 237.94 438.49 Tm (stu)Tj 0.263 0.263 0.255 rg 0.05 Tc 10.1441 0 0 9.7 250.46 438.49 Tm (dy )Tj 0.353 0.357 0.349 rg 9.7473 0 0 9.7 266.39 438.49 Tm (has )Tj 0.0013 Tc 9.7 0 0 9.7 53.77 427.93 Tm (been )Tj 0.263 0.263 0.255 rg 0.0438 Tc 2.227 0 Td (performed )Tj 0.353 0.357 0.349 rg -0.0186 Tc 4.84 0 Td (in )Tj 0.169 0.173 0.165 rg 0 Tc 1.21 0 Td (1)Tj 0.353 0.357 0.349 rg 0.425 0 Td (2 )Tj 0.0331 Tc 0.739 0 Td (dogs )Tj 0.0472 Tc 2.325 0 Td (according )Tj 0.0171 Tc 4.61 0 Td (to )Tj 0.263 0.263 0.255 rg -0.0062 Tc 1.188 0 Td (thi)Tj 0.435 0.435 0.428 rg 0 Tc 1.126 0 Td (s )Tj 0.353 0.357 0.349 rg 0.0451 Tc 0.659 0 Td (protocol: )Tj 0.263 0.263 0.255 rg 0.0097 Tc -19.352 -1.138 Td (the )Tj 0.353 0.357 0.349 rg 0.0478 Tc 1.583 0 Td (measurements )Tj 0.263 0.263 0.255 rg 0.0308 Tc 6.533 0 Td (were )Tj 0.353 0.357 0.349 rg 0.0438 Tc 2.377 0 Td (performed )Tj 0.263 0.263 0.255 rg 0.0359 Tc 4.948 0 Td (before )Tj 0.353 0.357 0.349 rg 0.05 Tc 10.0265 0 0 9.7 233.18 416.89 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.7525 0 0 9.7 252.38 416.89 Tm (after )Tj EMC ET BT /T1_0 1 Tf 0 Tc 11.4 0 0 11.4 275.4 416.89 Tm (a )Tj 0.0428 Tc 9.7 0 0 9.7 53.77 405.37 Tm (bronchospasm )Tj 0.263 0.263 0.255 rg 0.0281 Tc 6.721 0 Td (induced )Tj -0.0007 Tc 3.82 0 Td (by )Tj 0.353 0.357 0.349 rg 0.0263 Tc 1.374 0 Td (aerosolized )Tj 0.263 0.263 0.255 rg 0.0421 Tc 5.303 0 Td (methacholine)Tj 0.435 0.435 0.428 rg 0 Tc 5.87 0 Td (. )Tj 0.353 0.357 0.349 rg /T1_1 1 Tf 0.0272 Tc 9.8 0 0 9.8 52.26 394.81 Tm (The )Tj 0.263 0.263 0.255 rg /T1_0 1 Tf 0.05 Tc 9.9697 0 0 9.7 71.91 394.81 Tm (drug )Tj 0.353 0.357 0.349 rg 0.0417 Tc 9.7 0 0 9.7 95.03 394.81 Tm (was )Tj 0.0263 Tc 1.921 0 Td (aerosolized )Tj 0.263 0.263 0.255 rg -0.0186 Tc 5.198 0 Td (in )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0097 Tc 9.7 0 0 9.7 175.6661 394.81 Tm (the )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf 0.0368 Tc 9.7 0 0 9.7 191.5062 394.81 Tm (tracheal )Tj 0.0277 Tc 3.81 0 Td (tube, )Tj 0.05 Tc 9.9334 0 0 9.7 251.91 394.81 Tm (during )Tj 0.263 0.263 0.255 rg 0.0287 Tc 9.7 0 0 9.7 53.26 383.76 Tm (mechanical )Tj 0.353 0.357 0.349 rg 0.0217 Tc 5.146 0 Td (venti)Tj 0.169 0.173 0.165 rg 0 Tc 2.171 0 Td (l)Tj 0.353 0.357 0.349 rg 0.0477 Tc 0.245 0 Td (ation, )Tj 0.263 0.263 0.255 rg 0.0198 Tc 2.83 0 Td (with )Tj 0.353 0.357 0.349 rg 0 Tc 2.168 0 Td (a )Tj 0.263 0.263 0.255 rg 0.0469 Tc 0.847 0 Td (DeVilbiss )Tj 0.005 Tc 4.652 0 Td (42 )Tj 0.0246 Tc 1.389 0 Td (nebulizer )Tj 0.353 0.357 0.349 rg 0.0405 Tc -19.507 -1.138 Td (\(mass )Tj 0.263 0.263 0.255 rg 0.0364 Tc 3.325 0 Td (median )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.7653 0 0 9.7 123.75 372.72 Tm (diameter )Tj 11.1292 0 0 9.7 168.85 372.72 Tm (of )Tj 0.0345 Tc 9.7 0 0 9.7 186.22 372.72 Tm (the )Tj 0.05 Tc 9.779 0 0 9.7 206.78 372.72 Tm (aeroso)Tj 0.169 0.173 0.165 rg 0 Tc 9.7 0 0 9.7 235.6 372.72 Tm (l )Tj 0.263 0.263 0.255 rg 0.0474 Tc 1.048 0 Td (particle)Tj 0.435 0.435 0.428 rg 0 Tc 3.299 0 Td (, )Tj 0.263 0.263 0.255 rg 0.05 Tc 10.4241 0 0 9.7 52.75 361.69 Tm (MMAD)Tj 0.435 0.435 0.428 rg 0 Tc 9.7 0 0 9.7 88.55 361.69 Tm (: )Tj 0.353 0.357 0.349 rg -0.035 Tc 10.4978 0 0 10.5 93.48 361.69 Tm (3.8 )Tj ET BT /Suspect <>BDC 0.263 0.263 0.255 rg /C0_0 1 Tf 0 Tc 4.3201 0 0 7.68 108.49 361.69 Tm <007E0031006D>Tj 0.435 0.435 0.428 rg 1.92 0 0 7.68 122.4 361.69 Tm <003B0020>Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf 0.0409 Tc 9.7 0 0 9.7 126.64 361.69 Tm (geometric )Tj 0.435 0.435 0.428 rg 0 Tc 4.546 0 Td (s)Tj 0.263 0.263 0.255 rg 0.05 Tc 9.91 0 0 9.7 175.18 361.69 Tm (tandard )Tj 0.0441 Tc 9.7 0 0 9.7 210.63 361.69 Tm (deviation. )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf 0.05 Tc 9.9505 0 0 9.7 255.26 361.69 Tm (GSD: )Tj EMC ET BT 0.435 0.435 0.428 rg /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 52.74 350.65 Tm (2)Tj 0.263 0.263 0.255 rg -0.0146 Tc 0.53 0 Td (.8 )Tj ET BT /Suspect <>BDC /C0_0 1 Tf 0 Tc 3.84 0 0 7.68 68.17 350.65 Tm <007E0031006D002C0020>Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf 0.0323 Tc 9.7 0 0 9.7 86.3 350.65 Tm (allowing )Tj 0.0287 Tc 4.066 0 Td (maximal )Tj 0.263 0.263 0.255 rg 0.05 Tc 9.7767 0 0 9.7 164.65 350.65 Tm (bronchopulmonary )Tj 0.0342 Tc 9.7 0 0 9.7 249.03 350.65 Tm (deposi)Tj 0.435 0.435 0.428 rg 0 Tc 2.868 0 Td (\255)Tj 0.263 0.263 0.255 rg 0.0237 Tc -23.051 -1.089 Td (tion\) )Tj 0 Tc 2.465 0 Td (f)Tj 0.435 0.435 0.428 rg 0.05 Tc 10.5727 0 0 9.7 80.06 340.09 Tm (or )Tj 0.353 0.357 0.349 rg 0 Tc 9.7 0 0 9.7 93.06 340.09 Tm (2 )Tj 0.027 Tc 0.895 0 Td (min, )Tj 0.0198 Tc 2.327 0 Td (with )Tj 0.435 0.435 0.428 rg 0.0413 Tc 2.268 0 Td (conce)Tj 0.263 0.263 0.255 rg 0.0104 Tc 2.532 0 Td (ntraLions )Tj 0.0301 Tc 4.347 0 Td (increa)Tj 0.435 0.435 0.428 rg 0.0304 Tc 2.616 0 Td (sing )Tj 0.263 0.263 0.255 rg 0.0222 Tc 2.18 0 Td (from )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf 0.0012 Tc 9.7 0 0 9.7 52.6886 329.0514 Tm (0.25 )Tj EMC /Suspect <>BDC /T1_1 1 Tf 0.05 Tc 9.3199 0 0 8.4 74.84 329.05 Tm (to )Tj EMC /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 9.6214 0 0 10.6 87.74 329.05 Tm (50 )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf 0.05 Tc 9.7993 0 0 9.7 101.74 329.05 Tm (mg )Tj ET BT /Suspect <>BDC 0 g /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 115.96 329.05 Tm (\267 )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf -0.0104 Tc 9.7 0 0 9.7 119.9758 329.05 Tm (ml)Tj 0.624 0.628 0.612 rg 0 Tc 1.228 0 Td (-)Tj ET BT /Suspect <>BDC 0.263 0.263 0.255 rg /T1_0 1 Tf 0.05 Tc 8.3529 0 0 7.4001 138.7 329.05 Tm (t. )Tj EMC ET BT /T1_0 1 Tf 9.8951 0 0 9.7 148.78 329.05 Tm (to )Tj 0.0345 Tc 9.7 0 0 9.7 161.74 329.05 Tm (the )Tj 0.0455 Tc 1.785 0 Td (point )Tj 0.0342 Tc 2.769 0 Td (where )Tj 0.05 Tc 10.0889 0 0 9.7 235.19 329.05 Tm (no )Tj 9.7953 0 0 9.7 250.45 329.05 Tm (further )Tj 0.0369 Tc 9.7 0 0 9.7 52.24 318 Tm (increase )Tj 0.05 Tc 11.6856 0 0 9.7 89.17 318 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 9.6876 0 0 10.9 101.72 318 Tm (RL )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.8003 0 0 9.7 116.54 318 Tm (could )Tj 0.0068 Tc 9.7 0 0 9.7 144.01 318 Tm (be )Tj 0.0239 Tc 1.285 0 Td (registered; )Tj 0.05 Tc 9.8357 0 0 9.7 203.5 318 Tm (the )Tj 0.0478 Tc 9.7 0 0 9.7 219.34 318 Tm (measurements )Tj 0.0143 Tc -17.17 -1.137 Td (were )Tj 0.353 0.357 0.349 rg 0.0438 Tc 2.377 0 Td (performed )Tj 0.435 0.435 0.428 rg 0 Tc 4.892 0 Td (2 )Tj 0.263 0.263 0.255 rg 0.017 Tc 0.895 0 Td (min )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.7525 0 0 9.7 151.1 306.97 Tm (aflcr )Tj 0.0097 Tc 9.7 0 0 9.7 175.18 306.97 Tm (the )Tj 0.05 Tc 9.7687 0 0 9.7 190.94 306.97 Tm (end )Tj 11.1292 0 0 9.7 209.65 306.97 Tm (of )Tj 0.263 0.263 0.255 rg 0.0171 Tc 9.7 0 0 9.7 222.22 306.97 Tm (th)Tj 0.435 0.435 0.428 rg 0 Tc 0.833 0 Td (e )Tj 0.353 0.357 0.349 rg 0.0344 Tc 0.841 0 Td (aerosol. )Tj 0.263 0.263 0.255 rg 0.05 Tc 9.9723 0 0 9.7 62.31 295.93 Tm (The )Tj 0.0226 Tc 9.7 0 0 9.7 82.55 295.93 Tm (reversibility )Tj 0.353 0.357 0.349 rg 0.05 Tc 11.1292 0 0 9.7 136.21 295.93 Tm (of )Tj 0.263 0.263 0.255 rg 0.0345 Tc 9.7 0 0 9.7 149.26 295.93 Tm (the )Tj 0.353 0.357 0.349 rg 0.0228 Tc 1.726 0 Td (increase )Tj -0.0186 Tc 3.86 0 Td (in )Tj 0.169 0.173 0.165 rg 0 Tc 1.291 0 Td (R)Tj 0.353 0.357 0.349 rg 0.019 Tc 0.688 0 Td (coll )Tj 0.0389 Tc 1.979 0 Td (observed )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.7525 0 0 9.7 52.22 284.89 Tm (after )Tj EMC ET BT /T1_0 1 Tf 0.014 Tc 9.7 0 0 9.7 75.82 284.89 Tm (mecholyl )Tj 0.0323 Tc 4.247 0 Td (aerosol )Tj 0.0417 Tc 3.473 0 Td (was )Tj 0.0196 Tc 2.028 0 Td (tested )Tj -0.0007 Tc 2.873 0 Td (by )Tj 0.263 0.263 0.255 rg 0.0177 Tc 1.376 0 Td (inje)Tj 0.435 0.435 0.428 rg 0 Tc 1.533 0 Td (c)Tj 0.263 0.263 0.255 rg 0.0271 Tc 0.502 0 Td (ting )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_1 1 Tf -0.035 Tc 9.6598 0 0 10.1 250.44 284.89 Tm (0.4 )Tj EMC ET BT /T1_0 1 Tf 0.0017 Tc 9.7 0 0 9.7 266.87 284.89 Tm (rng )Tj 0.0362 Tc -22.077 -1.139 Td (isoproterenol )Tj 0.263 0.263 0.255 rg 0.0347 Tc 6.334 0 Td (intravenously )Tj -0.0186 Tc 6.433 0 Td (in )Tj 0.353 0.357 0.349 rg 0.0066 Tc 1.33 0 Td (seven )Tj 0.263 0.263 0.255 rg 0.0496 Tc 2.826 0 Td (dogs)Tj 0.435 0.435 0.428 rg 0 Tc 2.072 0 Td (, )Tj 0.263 0.263 0.255 rg 0.0325 Tc 0.799 0 Td (immedi\255)Tj 0.353 0.357 0.349 rg 0.0374 Tc -19.845 -1.089 Td (ately )Tj 0.05 Tc 9.7525 0 0 9.7 75.74 263.28 Tm (after )Tj 0.263 0.263 0.255 rg 0.0345 Tc 9.7 0 0 9.7 99.34 263.28 Tm (the )Tj 0.353 0.357 0.349 rg 0.0353 Tc 1.682 0 Td (measurements. )Tj 0.263 0.263 0.255 rg 0.05 Tc 10.0524 0 0 9.7 182.32 263.28 Tm (ln )Tj 9.939 0 0 9.7 193.81 263.28 Tm (four )Tj 0.353 0.357 0.349 rg 10.1049 0 0 9.7 215.42 263.28 Tm (other )Tj 0.263 0.263 0.255 rg 0.0496 Tc 9.7 0 0 9.7 241.35 263.28 Tm (dogs)Tj 0.522 0.525 0.518 rg 0 Tc 2.072 0 Td (, )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf 0.0291 Tc 9.7 0 0 9.7 266.7737 263.28 Tm (0.5 )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf 0.05 Tc 9.7993 0 0 9.7 52.3 252.25 Tm (mg )Tj 0.353 0.357 0.349 rg 9.967 0 0 9.7 67.58 252.25 Tm (atropine )Tj 0.0417 Tc 9.7 0 0 9.7 106.07 252.25 Tm (was )Tj 0.0245 Tc 1.873 0 Td (injected )Tj 0.0356 Tc 3.612 0 Td (intravenously. )Tj 0.263 0.263 0.255 rg 0.05 Tc 9.9723 0 0 9.7 222.15 252.25 Tm (The )Tj 0.0367 Tc 9.7 0 0 9.7 241.42 252.25 Tm (mea)Tj 0.435 0.435 0.428 rg 0 Tc 1.819 0 Td (s)Tj 0.263 0.263 0.255 rg 0.0247 Tc 0.41 0 Td (ure\255)Tj 0.0479 Tc -21.726 -1.138 Td (ments )Tj 0.0143 Tc 3.02 0 Td (were )Tj 0.033 Tc 2.474 0 Td (repeated )Tj 0 Tc 4.104 0 Td (4 )Tj 0.353 0.357 0.349 rg 0.017 Tc 0.992 0 Td (min )Tj 0.05 Tc 9.9904 0 0 9.7 174.62 241.21 Tm (after )Tj 0.0271 Tc 9.7 0 0 9.7 198.61 241.21 Tm (\(7)Tj 0.624 0.628 0.612 rg 0 Tc 0.841 0 Td (-)Tj 0.353 0.357 0.349 rg 0.637 0 Td (8 )Tj 0.263 0.263 0.255 rg 0.0417 Tc 0.956 0 Td (min )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.9904 0 0 9.7 242.3 241.21 Tm (after )Tj 0.263 0.263 0.255 rg 0.0345 Tc 9.7 0 0 9.7 266.86 241.21 Tm (the )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.7687 0 0 9.7 51.74 230.16 Tm (end )Tj 11.1292 0 0 9.7 69.97 230.16 Tm (of )Tj 0.263 0.263 0.255 rg 0.0345 Tc 9.7 0 0 9.7 82.06 230.16 Tm (the )Tj 0.353 0.357 0.349 rg 0.0213 Tc 1.576 0 Td (challenge\). )Tj 0.263 0.263 0.255 rg 0.0229 Tc 5 0 Td (In )Tj 0.435 0.435 0.428 rg 0.0477 Tc 1.18 0 Td (some )Tj 0.263 0.263 0.255 rg 0.0496 Tc 2.529 0 Td (dogs )Tj 0.353 0.357 0.349 rg 0.0465 Tc 2.334 0 Td (where )Tj 0.263 0.263 0.255 rg 0.0471 Tc 2.922 0 Td (bronchodi\255)Tj 0.0442 Tc -18.615 -1.137 Td (lators )Tj 0.353 0.357 0.349 rg 0.0473 Tc 2.729 0 Td (were )Tj 0.263 0.263 0.255 rg 0.05 Tc 9.7838 0 0 9.7 101.75 219.13 Tm (not )Tj 0.0174 Tc 9.7 0 0 9.7 118.48 219.13 Tm (injected)Tj 0.522 0.525 0.518 rg 0 Tc 3.358 0 Td (, )Tj 0.169 0.173 0.165 rg 0.0171 Tc 0.558 0 Td (th)Tj 0.353 0.357 0.349 rg 0 Tc 0.882 0 Td (e )Tj 0.263 0.263 0.255 rg 0.0299 Tc 0.744 0 Td (increase )Tj 0.353 0.357 0.349 rg 0.05 Tc 11.1292 0 0 9.7 208.69 219.13 Tm (of )Tj 0.169 0.173 0.165 rg 0 Tc 9.7 0 0 9.7 220.28 219.13 Tm (R)Tj 0.353 0.357 0.349 rg 0.05 Tc 9.8639 0 0 9.7 227.42 219.13 Tm (eo )Tj ET BT /Suspect <>BDC 0.263 0.263 0.255 rg /T1_1 1 Tf -0.035 Tc 9.3074 0 0 10 237.82 219.13 Tm (II )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf 0.0417 Tc 9.7 0 0 9.7 245.75 219.13 Tm (was )Tj ET BT /Suspect <>BDC 0.435 0.435 0.428 rg /T1_0 1 Tf 0.05 Tc 11.1184 0 0 9.7 264.32 219.13 Tm (st)Tj 0.263 0.263 0.255 rg -0.035 Tc 9.6664 0 0 9.7 271.6 219.13 Tm (ill )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.7739 0 0 9.7 51.7 208.09 Tm (stable )Tj 10.1194 0 0 9.7 80.06 208.09 Tm (at )Tj -0.035 Tc 8.5945 0 0 10.1 92.82 208.09 Tm (13 )Tj 0.027 Tc 9.7 0 0 9.7 105.1 208.09 Tm (min. )Tj 0.169 0.173 0.165 rg /T1_3 1 Tf 0.0185 Tc 9.4 0 0 9.4 150.19 181.21 Tm (Results )Tj 0.263 0.263 0.255 rg /T1_0 1 Tf 0.05 Tc 9.9723 0 0 9.7 61.35 164.41 Tm (The )Tj 0.0389 Tc 9.7 0 0 9.7 83.03 164.41 Tm (resu)Tj 0.094 0.094 0.086 rg 0 Tc 1.824 0 Td (l)Tj 0.263 0.263 0.255 rg 0.0291 Tc 0.303 0 Td (ts )Tj 0.05 Tc 9.7106 0 0 9.7 115.09 164.41 Tm (for )Tj 9.8357 0 0 9.7 132.94 164.41 Tm (the )Tj 0.0224 Tc 9.7 0 0 9.7 150.7 164.41 Tm (twe)Tj 0.094 0.094 0.086 rg 0 Tc 1.528 0 Td (l)Tj 0.263 0.263 0.255 rg 0.0027 Tc 0.254 0 Td (ve )Tj 0.0496 Tc 1.477 0 Td (dogs )Tj 0.0493 Tc 2.523 0 Td (afte)Tj 0.094 0.094 0.086 rg 0 Tc 1.692 0 Td (r )Tj 0.353 0.357 0.349 rg 0.0353 Tc 0.832 0 Td (aerosolize)Tj 0.169 0.173 0.165 rg 0 Tc 4.356 0 Td (d )Tj 0.263 0.263 0.255 rg 0.021 Tc -22.855 -1.089 Td (mecholyl )Tj 0.05 Tc 9.9087 0 0 9.7 95.9 153.85 Tm (are )Tj 0.0432 Tc 9.7 0 0 9.7 114.58 153.85 Tm (summarized )Tj 0.05 Tc 10.0636 0 0 9.7 171.76 153.85 Tm (in )Tj 0.0237 Tc 9.7 0 0 9.7 185.65 153.85 Tm (figure )Tj 0.0112 Tc 3.123 0 Td (2. )Tj 0.05 Tc 10.178 0 0 9.7 229.39 153.85 Tm (During )Tj 9.8357 0 0 9.7 266.38 153.85 Tm (the )Tj 0.0446 Tc 9.7 0 0 9.7 51.28 142.8 Tm (induced )Tj 0.0459 Tc 4.067 0 Td (bronchoconstriction, )Tj -0.0224 Tc 9.746 0 Td (we )Tj 0.0389 Tc 1.724 0 Td (observed )Tj 0 Tc 4.502 0 Td (a )Tj 0.05 Tc 9.7724 0 0 9.7 256.3 142.8 Tm (mean )Tj 0.0228 Tc 9.7 0 0 9.7 51.76 131.76 Tm (increase )Tj 0.05 Tc 11.1292 0 0 9.7 93.49 131.76 Tm (of )Tj 0.169 0.173 0.165 rg -0.035 Tc 9.6876 0 0 10.5 111.32 131.76 Tm (RL )Tj 0.263 0.263 0.255 rg 0.0387 Tc 9.7 0 0 9.7 131.41 131.76 Tm (from )Tj 0.353 0.357 0.349 rg 0.0277 Tc 2.974 0 Td (2.2 )Tj 0.263 0.263 0.255 rg 0.05 Tc 10.4772 0 0 9.7 180.93 131.76 Tm (to )Tj 0.0059 Tc 9.7 0 0 9.7 198.12 131.76 Tm (6.9 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.4454 0 0 9.7 218.3 131.76 Tm (cmH)Tj 0 Tc 6.5001 0 0 6.5001 239.96 129.37 Tm (2)Tj 0.05 Tc 18.185 0 0 14.8 243.65 131.76 Tm (0\267r)Tj 0 Tc 6.5001 0 0 6.5001 266.66 135.13 Tm (1)Tj 0.05 Tc 10.3962 0 0 9.7 271.94 131.76 Tm (\267s )Tj EMC /Suspect <>BDC 10.4576 0 0 9.7 51.24 120.72 Tm (\(p>BDC /T1_0 1 Tf 0.05 Tc 10.4481 0 0 9.7 97.42 110.16 Tm (ml\267cmH)Tj 0 Tc 6.5001 0 0 6.5001 134.36 107.76 Tm (2)Tj /T1_1 1 Tf 9.9 0 0 9.9 138.12 110.16 Tm (0)Tj 0.522 0.525 0.518 rg 0.876 0 Td (-)Tj 0.353 0.357 0.349 rg /T1_0 1 Tf 6.5001 0 0 6.5001 153.38 113.52 Tm (1 )Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg 0.05 Tc 10.4576 0 0 9.7 161.16 110.16 Tm (\(p>BDC 0.353 0.357 0.349 rg /T1_4 1 Tf 0.05 Tc 4.2445 0 0 3.2001 318.18 745.21 Tm (\(I\) )Tj EMC /Suspect <>BDC 0.706 0.706 0.702 rg /T1_0 1 Tf 0 Tc 4.1 0 0 4.1 325.36 745.21 Tm (.)Tj 0.263 0.263 0.255 rg 0.59 0 Td ($)Tj 0.435 0.435 0.428 rg 0.815 0 Td (. )Tj EMC /Suspect <>BDC 0.353 0.357 0.349 rg /T1_2 1 Tf 11.5 0 0 11.5 419.91 737.53 Tm (b )Tj EMC /Suspect <>BDC /C0_0 1 Tf 32.16 0 0 72 459.36 683.29 Tm <007E0020>Tj EMC /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 5.6819 0 0 11 316.72 729.36 Tm (ON )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf 6.4896 0 0 6.5001 328.31 729.36 Tm (t6 )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_2 1 Tf 11.8993 0 0 14.9 419.93 730.33 Tm (r: )Tj EMC ET BT /T1_0 1 Tf 5.9902 0 0 6.5001 434.37 732.73 Tm (zoo )Tj /T1_1 1 Tf 0 Tc 7.3001 0 0 7.3001 420.79 724.56 Tm (E )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 4.0592 0 0 6.8001 316.77 717.36 Tm (-=g )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 6.8782 0 0 6.5001 328.3 717.36 Tm (tz )Tj EMC /Suspect <>BDC 0 Tc 4.6 0 0 4.6 420.92 720.73 Tm (0 )Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg -22.33 -2.089 Td (0 )Tj EMC /Suspect <>BDC 0.353 0.357 0.349 rg /T1_1 1 Tf 9.1 0 0 9.1 419.79 712.09 Tm (E )Tj EMC /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 6.6905 0 0 9.7 317.24 698.17 Tm (a! )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf 0 Tc 5.8001 0 0 5.8001 330.62 703.44 Tm (8 )Tj ET BT /Suspect <>BDC 0.435 0.435 0.428 rg /T1_1 1 Tf -0.035 Tc 6.1047 0 0 11.5 420.8 703.44 Tm (... )Tj EMC /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf 4.6584 0 0 6.5001 434.87 704.89 Tm (tOO )Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg 0.05 Tc 8.2629 0 0 4.6 419.42 699.61 Tm (\(\) )Tj EMC /Suspect <>BDC 0.353 0.357 0.349 rg 0 Tc 6.1 0 0 6.1 439.62 678.48 Tm (0 )Tj EMC ET BT 0.435 0.435 0.428 rg /T1_1 1 Tf 4.2 0 0 4.2 350.33 672.24 Tm (\( )Tj ET BT /Suspect <>BDC 0.169 0.173 0.165 rg /T1_1 1 Tf 5.5001 0 0 5.5001 376.2 671.76 Tm (M )Tj EMC /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf -0.0242 Tc 6.5001 0 0 6.5001 392.61 672.24 Tm (P>BDC 0.263 0.263 0.255 rg /T1_1 1 Tf 16.5 0 0 16.5 486.02 665.05 Tm (" )Tj EMC /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 6.29 0 0 6.5001 502.05 672.24 Tm (P>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf -0.035 Tc 6.2517 0 0 6.5001 347.97 663.61 Tm (z7z )Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg 7.478 0 0 8.4 373.35 663.61 Tm (6.9 )Tj EMC /Suspect <>BDC 0.353 0.357 0.349 rg 3.992 0 0 7.4001 445.36 666 Tm (;;; )Tj EMC /Suspect <>BDC 6.3753 0 0 6.5001 457.91 664.56 Tm (t37 )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf 0.05 Tc 6.5049 0 0 6.5001 486.21 664.56 Tm (4t )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 8.9793 0 0 11.9 318.6 616.56 Tm ("' )Tj EMC /Suspect <>BDC 0.435 0.435 0.428 rg 11.86 0 0 11.9 328.17 614.65 Tm ('\267 )Tj EMC /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf 4.9323 0 0 6.5001 431.99 619.44 Tm (tOOO )Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg /T1_1 1 Tf 0 Tc 9.4 0 0 9.4 317.06 607.92 Tm (E )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf 6.1 0 0 6.1 331.12 609.36 Tm (5 )Tj ET BT /Suspect <>BDC 0.263 0.263 0.255 rg /T1_0 1 Tf 12.1 0 0 12.1 317.16 600.24 Tm (o )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf -0.035 Tc 9.091 0 0 12.1 320.93 600.24 Tm (.. )Tj 0.263 0.263 0.255 rg 0 Tc 5.1 0 0 5.1 331.18 595.92 Tm (4 )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 8.9793 0 0 11.9 422.28 590.65 Tm ("' )Tj EMC /Suspect <>BDC 5.2524 0 0 6.2 316.66 594 Tm (:X: )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_1 1 Tf 0 Tc 7.5001 0 0 7.5001 317.59 587.76 Tm (E )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 3.8001 0 0 3.8001 421.4 591.12 Tm (7 )Tj EMC /Suspect <>BDC 4.6 0 0 4.6 317.72 583.92 Tm (0 )Tj EMC ET BT 0.435 0.435 0.428 rg /T1_1 1 Tf 6.2 0 0 6.2 331.09 581.53 Tm (l )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_1 1 Tf 9.4 0 0 9.4 420.74 582 Tm (E )Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg /C0_0 1 Tf 4.32 0 0 5.28 317.77 572.89 Tm <007E0020>Tj EMC /Suspect <>BDC 5.76 0 0 10.08 420.96 570 Tm <007E0020>Tj EMC /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 8.2465 0 0 18.4 425.06 570 Tm (.. )Tj EMC /Suspect <>BDC /T1_0 1 Tf 4.9495 0 0 6.5001 435.35 574.33 Tm (tOO )Tj EMC /Suspect <>BDC /T1_1 1 Tf 9.977 0 0 12.8 317.63 563.29 Tm ("' )Tj EMC /Suspect <>BDC 0.435 0.435 0.428 rg /T1_0 1 Tf 0 Tc 9.4 0 0 9.4 331.15 568.09 Tm (z )Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg /T1_1 1 Tf -0.035 Tc 8.9793 0 0 11.9 317.64 560.41 Tm ("' )Tj EMC ET BT /T1_1 1 Tf 0 Tc 7.3001 0 0 7.3001 422.23 561.85 Tm (E )Tj ET BT /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 7.2988 0 0 9.2 316.27 560.89 Tm (a: )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0 Tc 4.6 0 0 4.6 422.36 558 Tm (0 )Tj EMC /Suspect <>BDC 0.353 0.357 0.349 rg /C0_0 1 Tf 2.88 0 0 6.72 401.29 534.97 Tm <0022>Tj 0.522 0.525 0.518 rg <007E0020>Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg /T1_0 1 Tf 7.1 0 0 7.1 420.89 545.53 Tm (0 )Tj EMC /Suspect <>BDC 4.6 0 0 4.6 422.36 541.68 Tm (0 )Tj EMC /Suspect <>BDC /T1_2 1 Tf -0.035 Tc 7.2988 0 0 9.2 420.91 537.36 Tm (a: )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf 0.0377 Tc 6.5001 0 0 6.5001 437.75 530.17 Tm (to )Tj 0.263 0.263 0.255 rg /T1_1 1 Tf 0 Tc 15.6 0 0 15.6 488.91 473.05 Tm (" )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 6.5239 0 0 6.5001 501.09 480.72 Tm (>BDC 0.353 0.357 0.349 rg -0.035 Tc 5.6706 0 0 6.5001 323.01 474 Tm (+200 )Tj EMC /Suspect <>BDC /C0_0 1 Tf 0 Tc 5.76 0 0 12.96 312.96 454.33 Tm <007E0020>Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg /T1_0 1 Tf -0.035 Tc 8.6539 0 0 9.2 433.35 457.69 Tm (Cs )Tj EMC /Suspect <>BDC 0.353 0.357 0.349 rg 5.3139 0 0 6.5001 322.54 446.65 Tm (+tOO )Tj EMC /Suspect <>BDC 5.5353 0 0 6.5001 431.02 446.16 Tm (+tOO )Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg 0.05 Tc 8.6152 0 0 5.2 326.23 418.81 Tm (;ll )Tj EMC /Suspect <>BDC 8.3503 0 0 7.2 434.37 418.81 Tm (41 )Tj EMC ET BT /T1_0 1 Tf 0.0375 Tc 6.5001 0 0 6.5001 322.49 393.37 Tm (-too )Tj /T1_1 1 Tf 0 Tc 14.6 0 0 14.6 378.52 386.65 Tm (" )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0389 Tc 6.1 0 0 6.1 373.89 386.65 Tm (+Bll )Tj EMC ET BT 0.169 0.173 0.165 rg /T1_0 1 Tf 0.0375 Tc 6.5001 0 0 6.5001 431.45 390.49 Tm (-too )Tj ET BT /Suspect <>BDC /T1_3 1 Tf -0.035 Tc 3.6427 0 0 5.9001 488.57 386.16 Tm (14 )Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg /T1_0 1 Tf 0.05 Tc 7.1003 0 0 6.5001 364.77 377.53 Tm (<0.05 )Tj EMC /Suspect <>BDC -0.035 Tc 10.2128 0 0 13.1 484.2 378.97 Tm (-\253s )Tj EMC /Suspect <>BDC -0.0094 Tc 6.5001 0 0 6.5001 501.57 377.53 Tm (P>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf -0.035 Tc 7.6033 0 0 8 334.04 360.25 Tm (Effe<:ls )Tj EMC ET BT 0.435 0.435 0.428 rg /T1_0 1 Tf 0.05 Tc 8.9033 0 0 8 358.96 360.25 Tm (of )Tj 0.353 0.357 0.349 rg 0.0203 Tc 8 0 0 8 368.08 360.25 Tm (aerosolized )Tj 0.0011 Tc 5.049 0 Td (mccholyl )Tj 0.435 0.435 0.428 rg 0.0404 Tc 4.071 0 Td (on )Tj 0.05 Tc 8.0143 0 0 8 452.14 360.25 Tm (the )Tj 0.353 0.357 0.349 rg 0.0306 Tc 8 0 0 8 464.63 360.25 Tm (various )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0279 Tc 8 0 0 8 492.014 360.25 Tm (parnmetcrs)Tj 0.624 0.628 0.612 rg 0 Tc 4.714 0 Td (: )Tj EMC /Suspect <>BDC 0.353 0.357 0.349 rg -0.035 Tc 6.8981 0 0 8.6 304.77 351.12 Tm (R.I. )Tj EMC ET BT 0.435 0.435 0.428 rg /T1_0 1 Tf 0.05 Tc 8.3916 0 0 8 316.72 351.12 Tm (on )Tj ET BT /Suspect <>BDC 0.263 0.263 0.255 rg /T1_0 1 Tf -0.035 Tc 7.5202 0 0 8 328.54 351.12 Tm (1h)Tj 0.435 0.435 0.428 rg 0 Tc 8 0 0 8 335.44 351.12 Tm (e )Tj EMC /Suspect <>BDC 0.353 0.357 0.349 rg -0.035 Tc 8.3323 0 0 8.8 342.17 351.12 Tm (lcfl )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf 0 Tc 8 0 0 8 356.09 351.12 Tm (l)Tj 0.435 0.435 0.428 rg 0.05 Tc 8.8578 0 0 8 358 351.12 Tm (op )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf -0.0335 Tc 8.8 0 0 8.8 370.09 351.12 Tm (panel. )Tj EMC /Suspect <>BDC 0.435 0.435 0.428 rg 0.0386 Tc 8 0 0 8 393.52 351.12 Tm (Ct)Tj 0.706 0.706 0.702 rg 0 Tc 0.895 0 Td (, )Tj EMC ET BT 0.435 0.435 0.428 rg /T1_0 1 Tf 0.0404 Tc 8 0 0 8 406 351.12 Tm (on )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf 0.05 Tc 8.0143 0 0 8 417.58 351.12 Tm (the )Tj EMC ET BT /T1_0 1 Tf 0.0383 Tc 8 0 0 8 431.03 351.12 Tm (right )Tj 0.05 Tc 8.0312 0 0 8 450.22 351.12 Tm (top )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0203 Tc 8.8 0 0 8.8 464.17 351.12 Tm (pancl)Tj 0.522 0.525 0.518 rg 0 Tc 2.11 0 Td (, )Tj EMC /Suspect <>BDC 0.263 0.263 0.255 rg 0.611 0 Td (R)Tj 0.435 0.435 0.428 rg -0.028 Tc 0.645 0 Td (saw )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.8578 0 0 8 509.2 351.12 Tm (on )Tj 0.353 0.357 0.349 rg 0.0212 Tc 8 0 0 8 521.26 351.12 Tm (the )Tj 0.0101 Tc -27.119 -1.14 Td (middle )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0404 Tc 8 0 0 8 330.652 342 Tm (lei\\ )Tj EMC /Suspect <>BDC 0.0232 Tc 1.81 0 Td (panel, )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf 0 Tc 8 0 0 8 369.564 342 Tm (R)Tj 0.435 0.435 0.428 rg -0.0112 Tc 0.655 0 Td (ooil )Tj 0.05 Tc 8.3916 0 0 8 390.64 342 Tm (on )Tj 0.353 0.357 0.349 rg 0.0276 Tc 8 0 0 8 403.61 342 Tm (lhe )Tj 0.0101 Tc 1.748 0 Td (middle )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0083 Tc 8 0 0 8 444.474 342 Tm (right )Tj EMC /Suspect <>BDC 0.0165 Tc 2.462 0 Td (panel)Tj 0.522 0.525 0.518 rg 0 Tc 2.264 0 Td (, )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf 0.0174 Tc 8 0 0 8 487.61 342 Tm (Tcoll )Tj 0.435 0.435 0.428 rg 0.0404 Tc 2.639 0 Td (on )Tj 0.263 0.263 0.255 rg 0.0212 Tc 1.567 0 Td (the )Tj 0.353 0.357 0.349 rg -0.0208 Tc 8.6 0 0 8.6 304.25 333.37 Tm (lower )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0116 Tc 8.6 0 0 8.6 325.8532 333.37 Tm (len )Tj EMC ET BT /T1_0 1 Tf 0.0232 Tc 8 0 0 8 339.37 333.37 Tm (panel, )Tj 0.435 0.435 0.428 rg /T1_2 1 Tf -0.0171 Tc 8.4 0 0 8.4 362.72 333.37 Tm (Cs )Tj /T1_0 1 Tf 0.0404 Tc 8 0 0 8 374.32 333.37 Tm (on )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf -0.035 Tc 7.7444 0 0 8 386.13 333.37 Tm (1hc )Tj EMC /Suspect <>BDC 0.0351 Tc 8 0 0 8 399.29 333.37 Tm (lower )Tj EMC ET BT /T1_0 1 Tf -0.0252 Tc 8.6 0 0 8.6 421.43 333.37 Tm (right )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0315 Tc 8 0 0 8 440.17 333.37 Tm (panel)Tj 0.624 0.628 0.612 rg 0 Tc 2.319 0 Td (. )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf 0.034 Tc 8 0 0 8 463.674 333.37 Tm (Absolute )Tj 0.435 0.435 0.428 rg 0.0187 Tc 4.2 0 Td (values )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf 0.05 Tc 8.0738 0 0 8 520.72 333.37 Tm (arc )Tj EMC /Suspect <>BDC -0.0105 Tc 8 0 0 8 304.32 324.25 Tm (used )Tj EMC ET BT /T1_0 1 Tf 0.0374 Tc 8 0 0 8 322.952 324.25 Tm (for )Tj 0.263 0.263 0.255 rg -0.035 Tc 7.7501 0 0 8.8 336.93 324.25 Tm (RL )Tj 0.435 0.435 0.428 rg 0.05 Tc 8.1466 0 0 8 349.36 324.25 Tm (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0062 Tc 8 0 0 8 365.68 324.25 Tm (Ct.. )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf 0 Tc 8.8 0 0 8.8 381.56 324.25 Tm (R)Tj 0.435 0.435 0.428 rg -0.035 Tc 8.7075 0 0 8.8 386.76 324.25 Tm (sa)Tj 0.263 0.263 0.255 rg 0 Tc 8.8 0 0 8.8 394.07 324.25 Tm (w )Tj 0.435 0.435 0.428 rg 0.05 Tc 8.1466 0 0 8 403.12 324.25 Tm (and )Tj ET BT /Suspect <>BDC 0.263 0.263 0.255 rg /T1_0 1 Tf 0 Tc 8 0 0 8 419.96 324.25 Tm (R)Tj 0.435 0.435 0.428 rg 0.0183 Tc 0.655 0 Td (coll. )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8 0 0 8 443.032 324.25 Tm (n)Tj 0.263 0.263 0.255 rg 0.0233 Tc 0.54 0 Td (nd )Tj ET BT /Suspect <>BDC 0.435 0.435 0.428 rg /T1_1 1 Tf 0 Tc 8.3 0 0 8.3 459.7 324.25 Tm (% )Tj EMC /Suspect <>BDC /T1_0 1 Tf -0.0126 Tc 8 0 0 8 470.8 324.25 Tm (cha.nges )Tj EMC /Suspect <>BDC 0.353 0.357 0.349 rg 0.0124 Tc 3.789 0 Td (rrom )Tj EMC /Suspect <>BDC 0.0212 Tc 2.519 0 Td (the )Tj EMC ET BT 0.435 0.435 0.428 rg /T1_0 1 Tf 0.0371 Tc 8 0 0 8 303.768 315.122 Tm (co)Tj 0.263 0.263 0.255 rg 0.05 Tc 8.3534 0 0 8 311.99 315.12 Tm (ntr)Tj 0.435 0.435 0.428 rg 0 Tc 8 0 0 8 322 315.12 Tm (o)Tj 0.263 0.263 0.255 rg 0.541 0 Td (l )Tj 0.353 0.357 0.349 rg 0.0074 Tc 0.597 0 Td (for )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0212 Tc 8 0 0 8 343.656 315.12 Tm (the )Tj EMC ET BT 0.435 0.435 0.428 rg /T1_0 1 Tf 0 Tc 8 0 0 8 355.592 315.12 Tm (o)Tj 0.263 0.263 0.255 rg 0.0053 Tc 0.608 0 Td (th)Tj 0.435 0.435 0.428 rg 0 Tc 0.833 0 Td (e)Tj 0.263 0.263 0.255 rg 0.489 0 Td (r )Tj 0.353 0.357 0.349 rg 0.0244 Tc 0.662 0 Td (purumetcrs. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 9.5292 0 0 8 418.46 315.12 Tm (Cis )Tj EMC ET BT 0.435 0.435 0.428 rg /T1_0 1 Tf 8.387 0 0 8 433.36 315.12 Tm (co)Tj 0.263 0.263 0.255 rg 0.0128 Tc 8 0 0 8 442.06 315.12 Tm (tllr)Tj 0.435 0.435 0.428 rg -0.035 Tc 6.606 0 0 8 451.62 315.12 Tm (o1 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.1466 0 0 8 460.72 315.12 Tm (and )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf 0 Tc 8 0 0 8 476.13 315.12 Tm (M )Tj 0.435 0.435 0.428 rg -0.035 Tc 7.8068 0 0 8 486.18 315.12 Tm (is )Tj 0.0143 Tc 8 0 0 8 493.36 315.12 Tm (aerosolized )Tj 0.263 0.263 0.255 rg 0.0072 Tc -23.691 -1.14 Td (mccholyl. )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.4239 0 0 8 339.25 306 Tm (\(n= )Tj ET BT /Suspect <>BDC 0.263 0.263 0.255 rg /T1_0 1 Tf -0.0116 Tc 7.8001 0 0 7.8001 354.93 306 Tm (12\). )Tj EMC ET BT /T1_0 1 Tf 0.0348 Tc 9.7 0 0 9.7 303.7 285.37 Tm (systematic )Tj 0.094 0.094 0.086 rg 0 Tc 5.202 0 Td (i)Tj 0.263 0.263 0.255 rg 0.0376 Tc 0.255 0 Td (ncrease )Tj 0.094 0.094 0.086 rg 0 Tc 3.902 0 Td (i)Tj 0.263 0.263 0.255 rg 0.304 0 Td (n )Tj 0.353 0.357 0.349 rg 0.035 Tc 1.179 0 Td (collateral )Tj 0.263 0.263 0.255 rg -0.0334 Tc 4.808 0 Td (re)Tj 0.435 0.435 0.428 rg 0.0327 Tc 0.778 0 Td (sista)Tj 0.263 0.263 0.255 rg 0.0014 Tc 1.993 0 Td (nce )Tj 0.353 0.357 0.349 rg 0.0331 Tc 2.068 0 Td (\(mean: )Tj /T1_1 1 Tf 0 Tc 12.8 0 0 12.8 305.07 274.33 Tm (+ )Tj ET BT /Suspect <>BDC 0.263 0.263 0.255 rg /T1_0 1 Tf 0.0442 Tc 9.7 0 0 9.7 314.54 274.33 Tm (1370%\) )Tj EMC ET BT /T1_0 1 Tf 0.0271 Tc 9.7 0 0 9.7 349.8092 274.33 Tm (followed )Tj 0.05 Tc 9.8357 0 0 9.7 390.22 274.33 Tm (the )Tj 0.353 0.357 0.349 rg 0.0344 Tc 9.7 0 0 9.7 405.98 274.33 Tm (aerosol. )Tj 0.263 0.263 0.255 rg 0.05 Tc 9.9723 0 0 9.7 442.47 274.33 Tm (The )Tj 0.0391 Tc 9.7 0 0 9.7 462.71 274.33 Tm (range )Tj 0.353 0.357 0.349 rg 0.05 Tc 10.5727 0 0 9.7 489.02 274.33 Tm (of )Tj 9.7237 0 0 9.7 500.55 274.33 Tm (control )Tj 0.263 0.263 0.255 rg 0.0251 Tc 9.7 0 0 9.7 303.82 263.28 Tm (values )Tj 0.05 Tc 9.8937 0 0 9.7 332.63 263.28 Tm (was )Tj 0.353 0.357 0.349 rg 0.027 Tc 9.7 0 0 9.7 351.7 263.28 Tm (so )Tj 0.263 0.263 0.255 rg 0.0304 Tc 1.201 0 Td (wide )Tj -0.035 Tc 9.6786 0 0 9.7 385.52 263.28 Tm ({fig. )Tj 0.353 0.357 0.349 rg 0.0123 Tc 9.5 0 0 9.5 405.49 263.28 Tm (3\) )Tj 0.05 Tc 10.215 0 0 9.7 417.1 263.28 Tm (that )Tj 0.0345 Tc 9.7 0 0 9.7 437.26 263.28 Tm (the )Tj 0.435 0.435 0.428 rg 0.05 Tc 10.1373 0 0 9.7 452.02 263.28 Tm (sta)Tj 0.263 0.263 0.255 rg -0.035 Tc 9.2906 0 0 9.7 465.1 263.28 Tm (ti)Tj 0.435 0.435 0.428 rg 0.0203 Tc 9.7 0 0 9.7 470.74 263.28 Tm (stics )Tj ET BT /Suspect <>BDC 0.263 0.263 0.255 rg /T1_0 1 Tf 0.0475 Tc 9.7 0 0 9.7 491.9927 263.28 Tm (had )Tj EMC ET BT /T1_0 1 Tf 0.0171 Tc 9.7 0 0 9.7 510.704 263.28 Tm (to )Tj 0.353 0.357 0.349 rg 0.0068 Tc 1.191 0 Td (be )Tj 0.05 Tc 9.78 0 0 9.7 303.74 252.73 Tm (computed )Tj 0.263 0.263 0.255 rg 0.0222 Tc 9.7 0 0 9.7 349.33 252.73 Tm (from )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.7156 0 0 9.7 372.4 252.73 Tm (logarithmic )Tj 0.0251 Tc 9.7 0 0 9.7 425.26 252.73 Tm (values )Tj 0.0171 Tc 3.068 0 Td (to )Tj 0.0418 Tc 1.179 0 Td (allow )Tj 0.0023 Tc 2.732 0 Td (us )Tj 0.263 0.263 0.255 rg 0.0171 Tc 1.285 0 Td (to )Tj 0.353 0.357 0.349 rg 1.188 0 Td (test )Tj 0.263 0.263 0.255 rg 0.026 Tc -21.931 -1.138 Td (for )Tj 0.353 0.357 0.349 rg -0.007 Tc 1.729 0 Td (significanL )Tj 0.263 0.263 0.255 rg 0.0241 Tc 4.904 0 Td (difference)Tj 0.435 0.435 0.428 rg 0 Tc 4.201 0 Td (s )Tj 0.263 0.263 0.255 rg /T1_1 1 Tf 0.0468 Tc 9 0 0 9 418.4 241.69 Tm (\(p )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf 0.05 Tc 10.5775 0 0 9.7 429.07 241.69 Tm (<0.0)Tj 0.094 0.094 0.086 rg 0 Tc 9.7 0 0 9.7 450.86 241.69 Tm (1)Tj 0.353 0.357 0.349 rg -0.035 Tc 9.0721 0 0 9.7 454.98 241.69 Tm (\). )Tj EMC /Suspect <>BDC 0.169 0.173 0.165 rg /T1_1 1 Tf 0.0275 Tc 9.4 0 0 9.4 466.06 241.69 Tm (fn )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf 0.0039 Tc 9.7 0 0 9.7 479.41 241.69 Tm (figure )Tj 0 Tc 10.5 0 0 10.5 508.2 241.69 Tm (3)Tj 0.522 0.525 0.518 rg 0.453 0 Td (, )Tj 0.263 0.263 0.255 rg -0.0224 Tc 9.7 0 0 9.7 520.31 241.69 Tm (we )Tj 0.353 0.357 0.349 rg 0.034 Tc -22.266 -1.138 Td (plotted )Tj 0.0345 Tc 3.758 0 Td (the )Tj ET BT /Suspect <>BDC 0.169 0.173 0.165 rg /T1_0 1 Tf 0 Tc 9.7 0 0 9.7 360.4443 230.6514 Tm (R)Tj 0.353 0.357 0.349 rg 0.0025 Tc 0.688 0 Td (coll )Tj EMC ET BT /T1_0 1 Tf 0.0251 Tc 9.7 0 0 9.7 389.2727 230.6514 Tm (values )Tj 0.263 0.263 0.255 rg 0.05 Tc 9.7525 0 0 9.7 421.34 230.65 Tm (after )Tj 0.021 Tc 9.7 0 0 9.7 447.82 230.65 Tm (mecholyl )Tj 0.353 0.357 0.349 rg 0.0315 Tc 4.545 0 Td (challenge )Tj 0.0499 Tc -19.399 -1.138 Td (against )Tj 0.263 0.263 0.255 rg 0.0256 Tc 3.472 0 Td (their )Tj 0.353 0.357 0.349 rg 0.0251 Tc 2.276 0 Td (values )Tj -0.0186 Tc 2.963 0 Td (in )Tj 0.435 0.435 0.428 rg 0.05 Tc 9.867 0 0 9.7 398.78 219.61 Tm (co)Tj 0.263 0.263 0.255 rg 0.0487 Tc 9.7 0 0 9.7 408.95 219.61 Tm (ntrol )Tj 0.435 0.435 0.428 rg 0.05 Tc 9.867 0 0 9.7 431.9 219.61 Tm (co)Tj 0.263 0.263 0.255 rg 0.0401 Tc 9.7 0 0 9.7 442.55 219.61 Tm (ndition)Tj 0.435 0.435 0.428 rg 0 Tc 3.154 0 Td (s )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0234 Tc 9.7 0 0 9.7 479.41 219.61 Tm (\(loga)Tj 0.263 0.263 0.255 rg 0.039 Tc 2.237 0 Td (rithmic )Tj EMC ET BT 0.435 0.435 0.428 rg /T1_0 1 Tf 0.0432 Tc 9.7 0 0 9.7 303.6945 208.5714 Tm (sca)Tj 0.263 0.263 0.255 rg -0.024 Tc 1.392 0 Td (le\))Tj 0.435 0.435 0.428 rg 0 Tc 1.071 0 Td (: )Tj 0.353 0.357 0.349 rg -0.0229 Tc 0.609 0 Td (all )Tj 0.0251 Tc 1.394 0 Td (values )Tj 0.05 Tc 9.7525 0 0 9.7 377.18 208.57 Tm (after )Tj 0.263 0.263 0.255 rg 0.0281 Tc 9.7 0 0 9.7 400.3 208.57 Tm (mecholyl )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.9087 0 0 9.7 441.98 208.57 Tm (are )Tj 0.0496 Tc 9.7 0 0 9.7 458.78 208.57 Tm (above )Tj 0.263 0.263 0.255 rg 0.0345 Tc 3.027 0 Td (the )Tj 0.0174 Tc 1.627 0 Td (line )Tj 0.353 0.357 0.349 rg 0.05 Tc 10.5727 0 0 9.7 522.62 208.57 Tm (of )Tj 0.0286 Tc 9.7 0 0 9.7 303.76 198.01 Tm (identity. )Tj 0.263 0.263 0.255 rg 0.0217 Tc 4.305 0 Td (Tcoll )Tj 0.353 0.357 0.349 rg 0.0282 Tc 2.967 0 Td (also )Tj 0.263 0.263 0.255 rg 0.0255 Tc 2.476 0 Td (increased )Tj ET BT /Suspect <>BDC 0.435 0.435 0.428 rg /T1_0 1 Tf 0.0482 Tc 9.7 0 0 9.7 444.3324 198.01 Tm (sig)Tj 0.263 0.263 0.255 rg 0.0205 Tc 1.251 0 Td (nificantly )Tj EMC ET BT 0.435 0.435 0.428 rg /T1_0 1 Tf 0.0173 Tc 9.7 0 0 9.7 502.4451 198.01 Tm (\(mea)Tj 0.263 0.263 0.255 rg -0.035 Tc 9.0971 0 0 9.7 523.67 198.01 Tm (n: )Tj 0.435 0.435 0.428 rg 0 Tc 11.9 0 0 11.9 305.22 186.97 Tm (+ )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.8909 0 0 9.7 313.75 186.97 Tm (83%\) )Tj 9.9989 0 0 9.7 339.24 186.97 Tm (\(p )Tj 0.435 0.435 0.428 rg 0 Tc 9.7 0 0 9.7 349.87 186.97 Tm (< )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf 0.0128 Tc 9.7 0 0 9.7 357.9792 186.97 Tm (0.05\), )Tj EMC ET BT /T1_0 1 Tf 0.0198 Tc 9.7 0 0 9.7 384.4699 186.97 Tm (with )Tj 0.263 0.263 0.255 rg 0.0345 Tc 2.176 0 Td (the )Tj 0.353 0.357 0.349 rg 0.0305 Tc 1.526 0 Td (exception )Tj 0.05 Tc 11.7014 0 0 9.7 463.57 186.97 Tm (oft )Tj 9.8458 0 0 9.7 478.07 186.97 Tm (wo )Tj 0.0331 Tc 9.7 0 0 9.7 492.87 186.97 Tm (dogs )Tj 0.435 0.435 0.428 rg 0 Tc 2.274 0 Td (\()Tj 0.263 0.263 0.255 rg -0.035 Tc 9.4177 0 0 9.7 518.3 186.97 Tm (fig. )Tj 0.353 0.357 0.349 rg -0.0178 Tc 9.8 0 0 9.8 303.78 175.93 Tm (2\). )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.023 Tc 9.7 0 0 9.7 318.06 175.93 Tm (Since )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf 0.05 Tc 9.7724 0 0 9.7 344.14 175.93 Tm (mean )Tj 0.0165 Tc 9.7 0 0 9.7 371.48 175.93 Tm (Rcoll )Tj 0.05 Tc 9.9799 0 0 9.7 397.43 175.93 Tm (had )Tj 0.353 0.357 0.349 rg 0.0255 Tc 9.7 0 0 9.7 417.04 175.93 Tm (increased )Tj 0.05 Tc 9.8247 0 0 9.7 460.3 175.93 Tm (more )Tj 10.0233 0 0 9.7 485.74 175.93 Tm (than )Tj 0.263 0.263 0.255 rg 0.0228 Tc 9.7 0 0 9.7 508.78 175.93 Tm (mean )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0267 Tc 9.7 0 0 9.7 303.2758 164.8914 Tm (Tcoll, )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 9.7724 0 0 9.7 330.7 164.89 Tm (mean )Tj 0.353 0.357 0.349 rg 9.7471 0 0 9.7 356.54 164.89 Tm (Cs )Tj 0.263 0.263 0.255 rg 0.0348 Tc 9.7 0 0 9.7 369.51 164.89 Tm (decreased )Tj 0.353 0.357 0.349 rg 0.0231 Tc 4.498 0 Td (significantly )Tj 0.0232 Tc 5.595 0 Td (\(mean: )Tj 0.522 0.525 0.518 rg 0 Tc 3.365 0 Td (-)Tj 0.263 0.263 0.255 rg 0.005 Tc 0.898 0 Td (44)Tj 0.435 0.435 0.428 rg 0.05 Tc 10.1115 0 0 9.7 518.78 164.89 Tm (%; )Tj ET BT /Suspect <>BDC 0.263 0.263 0.255 rg /T1_0 1 Tf 9.8232 0 0 9.7 303.38 153.85 Tm (p>BDC /T1_0 1 Tf -0.035 Tc 9.6876 0 0 9.7 458.84 121.2 Tm (RL )Tj EMC ET BT 0.353 0.357 0.349 rg /T1_0 1 Tf 0.05 Tc 11.1292 0 0 9.7 473.17 121.2 Tm (of )Tj 0.263 0.263 0.255 rg -0.035 Tc 9.5393 0 0 9.7 485.43 121.2 Tm (146)Tj 0.435 0.435 0.428 rg 0 Tc 9.7 0 0 9.7 499.58 121.2 Tm (% )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.7525 0 0 9.7 511.1 121.2 Tm (after )Tj 0.263 0.263 0.255 rg 0.0281 Tc 9.7 0 0 9.7 303.34 110.16 Tm (mecholyl )Tj 0.05 Tc 10.0757 0 0 9.7 347.9 110.16 Tm (aero)Tj 0.435 0.435 0.428 rg 0.027 Tc 9.7 0 0 9.7 367.06 110.16 Tm (so)Tj 0.263 0.263 0.255 rg 0 Tc 0.996 0 Td (l )Tj 0.353 0.357 0.349 rg 0.0271 Tc 0.937 0 Td (\(p )Tj 0.435 0.435 0.428 rg 0 Tc 10.6 0 0 10.6 395.95 110.16 Tm (< )Tj ET BT /Suspect <>BDC 0.353 0.357 0.349 rg /T1_0 1 Tf 0.0128 Tc 9.7 0 0 9.7 404.54 110.16 Tm (0.02\), )Tj EMC ET BT 0.263 0.263 0.255 rg /T1_0 1 Tf -0.0224 Tc 9.7 0 0 9.7 434.8719 110.16 Tm (we )Tj 0.353 0.357 0.349 rg 0.05 Tc 9.788 0 0 9.7 453.03 110.16 Tm (obse)Tj 0.169 0.173 0.165 rg 0 Tc 9.7 0 0 9.7 472.79 110.16 Tm (r)Tj 0.353 0.357 0.349 rg -0.0012 Tc 0.345 0 Td (ved )Tj 0 Tc 2.169 0 Td (a )Tj 0.05 Tc 10.0147 0 0 9.7 507.83 110.16 Tm (rapid )Tj 0.263 0.263 0.255 rg 0.0334 Tc 9.7 0 0 9.7 303.27 99.12 Tm (decrease )Tj 0.05 Tc 9.8951 0 0 9.7 343.18 99.12 Tm (to )Tj 0.026 Tc 9.7 0 0 9.7 356.63 99.12 Tm (nearly )Tj 0.353 0.357 0.349 rg 0.05 Tc 10.0038 0 0 9.7 386.3 99.12 Tm (contro)Tj 0.169 0.173 0.165 rg 0 Tc 9.7 0 0 9.7 414.64 99.12 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29.2799988 348 799.1999969 cm /Im1 Do Q q 39.3600006 0 0 20.1600037 278.8800049 804.9600067 cm /Im2 Do Q q 56.6399994 0 0 19.6799927 217.4400024 804.9600067 cm /Im3 Do Q q 147.3600006 0 0 172.8000031 0 651.3600006 cm /Im4 Do Q q 25.9199982 0 0 12.4799957 148.3200073 810.7200012 cm /Im5 Do Q q 20.6399994 0 0 168 0 482.3999939 cm /Im6 Do Q q 20.6399994 0 0 148.8000031 0 321.1199951 cm /Im7 Do Q q 48.4799957 0 0 296.6399994 0 23.5200043 cm /Im8 Do Q q 35.5200043 0 0 33.1199951 555.3600006 24 cm /Im9 Do Q q 25.9199982 0 0 12.4799957 432.4799957 27.3600006 cm /Im10 Do Q BT /Suspect <>BDC 0.275 0.275 0.263 rg /T1_0 1 Tf -0.0039 Tc 3 Tr 10.1 0 0 10.1 58.5 781.21 Tm (220 )Tj EMC ET BT 0.196 0.2 0.188 rg /T1_0 1 Tf 0.05 Tc 8.5548 0 0 7.9001 226.03 781.21 Tm (L. )Tj ET BT /Suspect <>BDC 0.275 0.275 0.263 rg /T1_0 1 Tf 8.6967 0 0 7.9001 239 781.21 Tm (DELAUNOIS, )Tj EMC ET BT /T1_0 1 Tf 0.026 Tc 7.9001 0 0 7.9001 299.97 781.21 Tm (M. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.5737 0 0 7.9001 314.84 781.21 Tm (DELAUNOIS )Tj EMC /Suspect <>BDC /T1_1 1 Tf 6.0432 0 0 5.6 85.3 759.12 Tm (Reo )Tj EMC /Suspect <>BDC 7.8667 0 0 5.6 97.22 759.12 Tm (II )Tj EMC ET BT 0.196 0.2 0.188 rg /T1_1 1 Tf 0 Tc 6.8001 0 0 6.8001 114.66 750.48 Tm (-)Tj 0.345 0.349 0.333 rg 0.471 0 Td (1 )Tj ET BT /Suspect <>BDC 0.408 0.412 0.4 rg /T1_0 1 Tf 7.4001 0 0 7.4001 61.18 743.29 Tm (1)Tj 0.275 0.275 0.263 rg 0.05 Tc 7.6027 0 0 7.4001 64.72 743.29 Tm (000 )Tj EMC /Suspect <>BDC 0.408 0.412 0.4 rg 0 Tc 7.4001 0 0 7.4001 85.84 746.17 Tm (e)Tj 0.275 0.275 0.263 rg 0.05 Tc 9.4364 0 0 7.4001 90.22 746.17 Tm (m\245 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 6.6237 0 0 7.4001 107.03 746.17 Tm (ml )Tj -0.0261 Tc 10.1 0 0 10.1 122.19 746.17 Tm (.s)Tj 0.549 0.553 0.537 rg 0 Tc 0.665 0 Td (. )Tj ET BT /Suspect <>BDC 0.275 0.275 0.263 rg /T1_0 1 Tf -0.035 Tc 6.2545 0 0 8.1 85.89 736.56 Tm (MECHOLYL )Tj EMC /Suspect <>BDC 0.0316 Tc 7.4001 0 0 7.4001 64.54 662.65 Tm (100 )Tj EMC /Suspect <>BDC 0.196 0.2 0.188 rg 0 Tc 2.224 0 Td (\225 )Tj EMC /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 5.822 0 0 6.7 68.93 582.97 Tm (10 )Tj EMC /Suspect <>BDC 0.275 0.275 0.263 rg 0 Tc 11.2 0 0 11.2 152.95 704.89 Tm (\225 )Tj EMC /Suspect <>BDC -0.035 Tc 6.674 0 0 6.7 231.63 492.72 Tm (100 )Tj EMC ET BT /T1_0 1 Tf 0.0245 Tc 6.8001 0 0 6.8001 257.73 489.37 Tm (Rcoll )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 0.0251 Tc 6.6 0 0 6.6 257.19 478.81 Tm (Control )Tj EMC ET BT /T1_0 1 Tf -0.0146 Tc 8.2 0 0 8.2 57.09 461.05 Tm (Fig. )Tj -0.035 Tc 7.7865 0 0 8.2 72.39 461.05 Tm (3. )Tj 0.196 0.2 0.188 rg -0.0286 Tc 8.2 0 0 8.2 86.83 461.05 Tm (Effect )Tj 0.275 0.275 0.263 rg 0.05 Tc 9.4598 0 0 8.2 107.91 461.05 Tm (of )Tj 0.0029 Tc 8.2 0 0 8.2 117.52 461.05 Tm (aerosolized )Tj -0.0035 Tc 4.924 0 Td (mecholyl )Tj 0.05 Tc 8.3916 0 0 8.2 190.48 461.05 Tm (on )Tj 0.0058 Tc 8.2 0 0 8.2 202.06 461.05 Tm (the )Tj 0.0189 Tc 1.456 0 Td (collateral )Tj 0.196 0.2 0.188 rg -0.0031 Tc 4.223 0 Td (resistance, )Tj -0.0133 Tc -23.36 -1.112 Td (Rcoll)Tj 0.345 0.349 0.333 rg 0 Tc 2.15 0 Td (. )Tj 0.275 0.275 0.263 rg -0.0103 Tc 0.718 0 Td (Mecholyl )Tj -0.0059 Tc 4.276 0 Td (values )Tj 0.0399 Tc 2.92 0 Td (are )Tj 0.05 Tc 8.3916 0 0 8.2 153.52 451.93 Tm (on )Tj 0.0058 Tc 8.2 0 0 8.2 166.06 451.93 Tm (the )Tj 0.0232 Tc 1.632 0 Td (ordinate, )Tj 0.045 Tc 4.156 0 Td (and )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0079 Tc 8.2 0 0 8.2 229.364 451.93 Tm (controls, )Tj EMC ET BT /T1_0 1 Tf 0.0155 Tc 8.2 0 0 8.2 260.565 451.93 Tm (on )Tj 0.0058 Tc 1.529 0 Td (the )Tj -0.0073 Tc -26.407 -1.055 Td (abscissa. )Tj 0.0182 Tc 3.866 0 Td (Identity )Tj 0.196 0.2 0.188 rg 0.0134 Tc 3.57 0 Td (line )Tj 0.275 0.275 0.263 rg -0.035 Tc 7.8068 0 0 8.2 132.42 443.28 Tm (is )Tj 0.345 0.349 0.333 rg 0.0498 Tc 8.2 0 0 8.2 140.04 443.28 Tm (sho)Tj 0.196 0.2 0.188 rg -0.035 Tc 8.1181 0 0 8.2 152.15 443.28 Tm (wn)Tj 0.408 0.412 0.4 rg 0 Tc 8.2 0 0 8.2 162.59 443.28 Tm (, )Tj 0.275 0.275 0.263 rg 0.045 Tc 0.533 0 Td (and )Tj ET BT /Suspect <>BDC 0.345 0.349 0.333 rg /T1_0 1 Tf 0 Tc 8.2 0 0 8.2 182.3192 443.28 Tm (a)Tj 0.196 0.2 0.188 rg -0.035 Tc 7.6228 0 0 8.2 186.66 443.28 Tm (ll )Tj EMC ET BT 0.275 0.275 0.263 rg /T1_0 1 Tf 0.0283 Tc 8.2 0 0 8.2 193.45 443.28 Tm (points )Tj 0.345 0.349 0.333 rg 0.0107 Tc 2.916 0 Td (are )Tj 0.275 0.275 0.263 rg 0.0135 Tc 1.58 0 Td (above. )Tj 0.0413 Tc 10.1 0 0 10.1 56.04 408.25 Tm (\(p )Tj /T1_1 1 Tf 0 Tc 1.042 0 Td (< )Tj ET BT /Suspect <>BDC 0.196 0.2 0.188 rg /T1_0 1 Tf -0.0155 Tc 10.1 0 0 10.1 74.7856 408.25 Tm (0.02\). )Tj EMC ET BT 0.275 0.275 0.263 rg /T1_0 1 Tf 0.05 Tc 10.2656 0 0 10.1 102.15 408.25 Tm (The )Tj 0.0214 Tc 10.1 0 0 10.1 123.22 408.25 Tm (same )Tj 0.0238 Tc 2.522 0 Td (evolution )Tj -0.0144 Tc 4.43 0 Td (was )Tj 0.017 Tc 1.987 0 Td (observed )Tj 0.0184 Tc 4.182 0 Td (on )Tj -0.035 Tc 9.8409 0 0 10.1 270.62 408.25 Tm (CL )Tj 0.0143 Tc 10.1 0 0 10.1 56.14 397.21 Tm (measurements, )Tj 0.0115 Tc 6.464 0 Td (with )Tj 0 Tc 2.082 0 Td (a )Tj 0.0127 Tc 0.76 0 Td (decrease )Tj 0.05 Tc 11.1292 0 0 10.1 188.05 397.21 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0225 Tc 10.1 0 0 10.1 200.05 397.21 Tm (70% )Tj EMC ET BT /T1_0 1 Tf 0.0326 Tc 10.1 0 0 10.1 222.1387 397.21 Tm (after )Tj -0.0008 Tc 2.242 0 Td (mecholyl )Tj -0.0062 Tc -18.687 -1.046 Td (\(p )Tj ET BT /Suspect <>BDC 0.345 0.349 0.333 rg /T1_0 1 Tf 0.05 Tc 10.3316 0 0 10.1 66.67 386.65 Tm (<0.0)Tj 0.196 0.2 0.188 rg -0.035 Tc 9.6857 0 0 10.1 88.46 386.65 Tm (1\), )Tj EMC ET BT 0.275 0.275 0.263 rg /T1_0 1 Tf 0.0104 Tc 10.1 0 0 10.1 103.6 386.65 Tm (increasing )Tj 0.0333 Tc 4.711 0 Td (to )Tj 0.0052 Tc 1.379 0 Td (nearly )Tj 0.0386 Tc 3.033 0 Td (control )Tj 0.004 Tc 3.572 0 Td (values )Tj 0.0326 Tc 3.081 0 Td (after )Tj 0.0214 Tc -20.481 -1.093 Td (isoproterenol )Tj 0.0413 Tc 6.032 0 Td (\(p )Tj 0.345 0.349 0.333 rg /T1_1 1 Tf 0 Tc 10.5 0 0 10.5 127.99 375.61 Tm (< )Tj ET BT /Suspect <>BDC 0.275 0.275 0.263 rg /T1_0 1 Tf -0.006 Tc 10.1 0 0 10.1 135.74 375.61 Tm (0.05\). )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 10.1883 0 0 10.1 165.17 375.61 Tm (No )Tj 0.0086 Tc 10.1 0 0 10.1 183.22 375.61 Tm (significant )Tj 0.0275 Tc 4.804 0 Td (change )Tj 0.0094 Tc 3.478 0 Td (was )Tj 0.0103 Tc -20.872 -1.094 Td (observed )Tj -0.0005 Tc 4.089 0 Td (in )Tj 0.196 0.2 0.188 rg 0.0212 Tc 1.191 0 Td (Rsaw )Tj 0.275 0.275 0.263 rg 0.0241 Tc 2.702 0 Td (\(but )Tj 0.0232 Tc 2.101 0 Td (measurable )Tj 0.0386 Tc 5.125 0 Td (control )Tj -0.0055 Tc 3.477 0 Td (values )Tj -0.0005 Tc 2.941 0 Td (in )Tj 0.0244 Tc -21.627 -1.092 Td (four )Tj 0.196 0.2 0.188 rg 0.007 Tc 2.092 0 Td (dogs )Tj 0.275 0.275 0.263 rg -0.0022 Tc 2.329 0 Td (only\). )Tj 0.0129 Tc 2.761 0 Td (However, )Tj ET BT /Suspect <>BDC 0.196 0.2 0.188 rg /T1_0 1 Tf 0.0121 Tc 10.1 0 0 10.1 173.2311 353.5314 Tm (Rcoll, )Tj EMC ET BT 0.275 0.275 0.263 rg /T1_0 1 Tf 0.009 Tc 10.1 0 0 10.1 202.5413 353.5314 Tm (the )Tj 0.025 Tc 1.616 0 Td (mean )Tj 0.05 Tc 11.1292 0 0 10.1 245.17 353.53 Tm (of )Tj 0.0084 Tc 10.1 0 0 10.1 257.27 353.53 Tm (which )Tj 0.0171 Tc -19.913 -1.093 Td (had )Tj 0.0059 Tc 2.132 0 Td (increased )Tj 0.196 0.2 0.188 rg 0.0251 Tc 4.473 0 Td (markedly )Tj 0.275 0.275 0.263 rg 0.0326 Tc 4.554 0 Td (after )Tj -0.0022 Tc 2.574 0 Td (mecholyl, )Tj 0.196 0.2 0.188 rg 0.014 Tc 4.602 0 Td (decreased )Tj 0.345 0.349 0.333 rg 0.0058 Tc -18.396 -1.094 Td (significantly )Tj 0.275 0.275 0.263 rg 0.0196 Tc 5.477 0 Td (towards )Tj 0.0307 Tc 3.699 0 Td (control )Tj 0.004 Tc 3.43 0 Td (values )Tj 0.0326 Tc 2.986 0 Td (after )Tj 0.0203 Tc 2.331 0 Td (isoprotere\255)Tj -0.019 Tc -17.862 -1.045 Td (nol )Tj 0.0108 Tc 1.942 0 Td (injection )Tj -0.0062 Tc 4.273 0 Td (\(p )Tj 0.345 0.349 0.333 rg 0 Tc 1.005 0 Td (< )Tj ET BT /Suspect <>BDC 0.275 0.275 0.263 rg /T1_0 1 Tf 0.0036 Tc 10.1 0 0 10.1 137.181 320.8868 Tm (0.0 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 10.1 0 0 10.1 151.6139 320.8868 Tm (I )Tj /T1_2 1 Tf -0.035 Tc 10.3242 0 0 10.6 162.18 320.89 Tm (versus )Tj /T1_0 1 Tf 0.0037 Tc 10.1 0 0 10.1 193.42 320.89 Tm (mecholyl, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.723 0 0 7.9001 241 320.89 Tm (NS )Tj EMC ET BT /T1_2 1 Tf 10.1217 0 0 10.6 258.18 320.89 Tm (versus )Tj /T1_0 1 Tf 0.0307 Tc 10.1 0 0 10.1 55.1 309.84 Tm (control )Tj -0.0058 Tc 3.43 0 Td (values\). )Tj 0.0396 Tc 3.51 0 Td (The )Tj 0.0103 Tc 1.997 0 Td (increase )Tj -0.035 Tc 9.9195 0 0 10.1 182.8 309.84 Tm (in )Tj 0.025 Tc 10.1 0 0 10.1 193.9 309.84 Tm (mean )Tj 0.012 Tc 2.607 0 Td (Tcoll )Tj 0.05 Tc 10.7862 0 0 10.1 246.11 309.84 Tm (\(+52%\) )Tj 0.345 0.349 0.333 rg 0.0208 Tc 10.1 0 0 10.1 55.58 298.81 Tm (after )Tj 0.275 0.275 0.263 rg -0.0008 Tc 2.337 0 Td (mecholyl )Tj -0.0272 Tc 4.125 0 Td (\(five )Tj 0.05 Tc 10.261 0 0 10.1 142.94 298.81 Tm (out )Tj 10.5727 0 0 10.1 161.18 298.81 Tm (of )Tj -0.0159 Tc 10.1 0 0 10.1 173.62 298.81 Tm (seven )Tj 0.017 Tc 2.665 0 Td (dogs\) )Tj 0.0094 Tc 2.67 0 Td (was )Tj 0.196 0.2 0.188 rg -0.0013 Tc 1.996 0 Td (reversed )Tj 0.275 0.275 0.263 rg 0.0326 Tc -19.066 -1.094 Td (after )Tj 0.0203 Tc 2.283 0 Td (isop)Tj 0.09 0.094 0.082 rg 0 Tc 1.765 0 Td (r)Tj 0.275 0.275 0.263 rg 0.0174 Tc 0.371 0 Td (oterenol )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0334 Tc 7.9001 0 0 7.9001 137.67 287.76 Tm (\(NS\). )Tj EMC ET BT /T1_0 1 Tf 0.021 Tc 10.1 0 0 10.1 160.3 287.76 Tm (After )Tj 0.009 Tc 2.566 0 Td (the )Tj 0.0127 Tc 1.56 0 Td (decrease )Tj 0.05 Tc 11.1292 0 0 10.1 240.85 287.76 Tm (of )Tj 0.0121 Tc 10.1 0 0 10.1 252.86 287.76 Tm (Cs )Tj 0.0434 Tc 1.378 0 Td (due )Tj 0.0333 Tc -20.903 -1.093 Td (to )Tj -0.0008 Tc 1.616 0 Td (mecholyl )Tj 0 Tc 4.505 0 Td (\()Tj 0.549 0.553 0.537 rg 0.475 0 Td (-)Tj 0.275 0.275 0.263 rg 0.0305 Tc 0.863 0 Td (45%; )Tj 0 Tc 3 0 Td (p )Tj 0.345 0.349 0.333 rg 0.706 0 Td (< )Tj ET BT /Suspect <>BDC 0.275 0.275 0.263 rg /T1_0 1 Tf -0.006 Tc 10.1 0 0 10.1 176.5343 276.7207 Tm (0.05\), )Tj EMC ET BT /T1_0 1 Tf 0.0328 Tc 10.1 0 0 10.1 208.2988 276.7207 Tm (the )Tj 0.196 0.2 0.188 rg 0.0049 Tc 2.085 0 Td (injection )Tj 0.275 0.275 0.263 rg 0.05 Tc 11.1292 0 0 10.1 273.49 276.72 Tm (of )Tj 0.196 0.2 0.188 rg 0.0175 Tc 10.1 0 0 10.1 55.6 265.69 Tm (isoproterenol )Tj 0.275 0.275 0.263 rg 0.0156 Tc 5.9 0 Td (restored )Tj 0.009 Tc 3.753 0 Td (the )Tj 0.025 Tc 1.568 0 Td (mean )Tj 0.0121 Tc 2.606 0 Td (Cs )Tj -0.0143 Tc 1.481 0 Td (to )Tj 0.0307 Tc 1.133 0 Td (control )Tj -0.0055 Tc 3.43 0 Td (values )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.3305 0 0 10.1 55.08 255.13 Tm (\(p<0.05\) )Tj EMC ET BT /T1_0 1 Tf 0.0145 Tc 10.1 0 0 10.1 97.8 255.13 Tm (\(statistics )Tj 0.0184 Tc 4.279 0 Td (on )Tj 0.0211 Tc 1.427 0 Td (logarithmic )Tj 0.001 Tc 5.14 0 Td (values\). )Tj 0.196 0.2 0.188 rg 0.0396 Tc -14.122 -1.093 Td (The )Tj 0.275 0.275 0.263 rg 0.0089 Tc 2.004 0 Td (results )Tj 0.196 0.2 0.188 rg 0.05 Tc 11.1292 0 0 10.1 115.57 244.09 Tm (of )Tj 0.275 0.275 0.263 rg 0.0328 Tc 10.1 0 0 10.1 128.14 244.09 Tm (the )Tj -0.0046 Tc 1.607 0 Td (effects )Tj 0.05 Tc 11.1292 0 0 10.1 174.13 244.09 Tm (of )Tj 0.0364 Tc 10.1 0 0 10.1 186.62 244.09 Tm (atropine )Tj 0.05 Tc 10.2564 0 0 10.1 225.98 244.09 Tm (on )Tj 0.0111 Tc 10.1 0 0 10.1 239.98 244.09 Tm (mecholyl\255)Tj 0.0141 Tc -18.303 -1.093 Td (induced )Tj 0.0247 Tc 3.811 0 Td (bronchospasm )Tj 0.0376 Tc 6.595 0 Td (are )Tj 0.345 0.349 0.333 rg 0.0452 Tc 1.754 0 Td (summa)Tj 0.196 0.2 0.188 rg -0.0118 Tc 3.102 0 Td (rized )Tj 0.275 0.275 0.263 rg -0.0005 Tc 2.512 0 Td (in )Tj 0.0037 Tc 1.28 0 Td (figure )Tj /T1_2 1 Tf 0 Tc 10.7 0 0 10.7 277.33 233.05 Tm (5 )Tj 0.345 0.349 0.333 rg /T1_0 1 Tf 10.1 0 0 10.1 55.08 222.01 Tm (\()Tj 0.196 0.2 0.188 rg 0.0402 Tc 0.286 0 Td (four )Tj 0.0017 Tc 2.092 0 Td (dogs\). )Tj 0.275 0.275 0.263 rg 0.0329 Tc 2.859 0 Td (After )Tj 0.05 Tc 10.2654 0 0 10.1 133.34 222.01 Tm (an )Tj 0.0171 Tc 10.1 0 0 10.1 146.8 222.01 Tm (increase )Tj 0.05 Tc 10.5727 0 0 10.1 184.22 222.01 Tm (of )Tj 0.196 0.2 0.188 rg 0.0065 Tc 10.1 0 0 10.1 196.93 222.01 Tm (142% )Tj 0.275 0.275 0.263 rg 0.0413 Tc 2.637 0 Td (\(p )Tj ET BT /Suspect <>BDC 0.345 0.349 0.333 rg /T1_0 1 Tf 0.0434 Tc 10.1 0 0 10.1 234.6737 222.01 Tm (<0.02\) )Tj EMC ET BT 0.275 0.275 0.263 rg /T1_0 1 Tf 10.1 0 0 10.1 266.3069 222.01 Tm (due )Tj 0.0333 Tc -20.903 -1.047 Td (to )Tj 0.0037 Tc 1.806 0 Td (mecholyl, )Tj 0.025 Tc 5.038 0 Td (mean )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 10.0751 0 0 10.1 157.39 211.44 Tm (RL )Tj EMC ET BT /T1_0 1 Tf 0.008 Tc 10.1 0 0 10.1 179.9 211.44 Tm (decreased )Tj 0.0019 Tc 5.034 0 Td (significantly )Tj 0.05 Tc 11.7529 0 0 10.1 54.58 200.41 Tm (\(-52%\) )Tj 0.0326 Tc 10.1 0 0 10.1 94.46 200.41 Tm (after )Tj 0.0244 Tc 2.329 0 Td (atropine. )Tj -0.035 Tc 9.8409 0 0 10.1 159.74 200.41 Tm (CL )Tj 0.196 0.2 0.188 rg 0.014 Tc 10.1 0 0 10.1 175.1 200.41 Tm (decreased )Tj 0.275 0.275 0.263 rg 0.0326 Tc 4.467 0 Td (after )Tj -0.0008 Tc 2.337 0 Td (mecholyl )Tj 0 Tc -18.735 -1.093 Td (\()Tj 0.549 0.553 0.537 rg 0.475 0 Td (-)Tj 0.275 0.275 0.263 rg 0.0209 Tc 0.853 0 Td (54%; )Tj 0 Tc 2.535 0 Td (p )Tj 0.345 0.349 0.333 rg 0.706 0 Td (< )Tj ET BT /Suspect <>BDC 0.275 0.275 0.263 rg /T1_0 1 Tf -0.0045 Tc 10.1 0 0 10.1 108.3693 189.3707 Tm (0.05\) )Tj EMC ET BT /T1_0 1 Tf 0.0444 Tc 10.1 0 0 10.1 132.3669 189.3707 Tm (and )Tj 0.0118 Tc 1.903 0 Td (increased )Tj 0.0204 Tc 4.18 0 Td (again )Tj 0.0208 Tc 2.614 0 Td (after )Tj 0.0222 Tc 2.292 0 Td (broncho\255)Tj 0.0214 Tc -18.688 -1.093 Td (dilators )Tj 0.196 0.2 0.188 rg 0.0115 Tc 3.858 0 Td (with )Tj 0.275 0.275 0.263 rg 0.0037 Tc 2.519 0 Td (wide )Tj 0.196 0.2 0.188 rg 0.0262 Tc 2.66 0 Td (variation )Tj 0.275 0.275 0.263 rg /T1_1 1 Tf -0.035 Tc 9.1388 0 0 9.7 191.36 178.33 Tm (\(Ns\). )Tj /T1_0 1 Tf 0.05 Tc 10.5656 0 0 10.1 217.49 178.33 Tm (No )Tj 0.0039 Tc 10.1 0 0 10.1 238.42 178.33 Tm (significant )Tj 0.0215 Tc -18.246 -1.093 Td (changes )Tj -0.0119 Tc 3.906 0 Td (were )Tj 0.017 Tc 2.415 0 Td (observed )Tj -0.0005 Tc 4.279 0 Td (in )Tj 0.196 0.2 0.188 rg 0.025 Tc 1.337 0 Td (mean )Tj 0.0053 Tc 2.849 0 Td (Rsaw )Tj 0.345 0.349 0.333 rg 0.0247 Tc 2.797 0 Td (\(th)Tj 0.196 0.2 0.188 rg 0.0085 Tc 1.247 0 Td (ree )Tj 0.275 0.275 0.263 rg 0.007 Tc 1.75 0 Td (dogs )Tj -0.0022 Tc -20.531 -1.093 Td (only\). )Tj 0.0329 Tc 3.002 0 Td (After )Tj 0 Tc 2.844 0 Td (a )Tj -0.0008 Tc 1.101 0 Td (mecholyl)Tj 0.408 0.412 0.4 rg 0 Tc 3.792 0 Td (-)Tj 0.275 0.275 0.263 rg 0.0141 Tc 0.337 0 Td (induced )Tj 0.0103 Tc 3.897 0 Td (increase )Tj -0.035 Tc 9.9195 0 0 10.1 246.16 156.25 Tm (in )Tj 0.0244 Tc 10.1 0 0 10.1 260.62 156.25 Tm (three )Tj 0.05 Tc 10.261 0 0 10.1 54.14 145.69 Tm (out )Tj 11.1292 0 0 10.1 75.25 145.69 Tm (of )Tj 0.0086 Tc 10.1 0 0 10.1 91.57 145.69 Tm (four )Tj 0.007 Tc 2.425 0 Td (dogs )Tj 0.0223 Tc 2.659 0 Td (\(mean )Tj 0.0212 Tc 3.321 0 Td (86%; )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0277 Tc 7.9001 0 0 7.9001 205.96 145.69 Tm (NS\), )Tj EMC ET BT /T1_0 1 Tf 0.0092 Tc 10.1 0 0 10.1 228.94 145.69 Tm (mean )Tj 0.0064 Tc 2.991 0 Td (Rcoll )Tj 0.008 Tc -20.298 -1.093 Td (decreased )Tj 0.345 0.349 0.333 rg 0.0058 Tc 5.129 0 Td (significantly )Tj 0.0119 Tc 6.182 0 Td (afte)Tj 0.196 0.2 0.188 rg 0 Tc 1.577 0 Td (r )Tj 0.275 0.275 0.263 rg 0.0364 Tc 1.417 0 Td (atropine )Tj 0 Tc 4.655 0 Td (\()Tj 0.408 0.412 0.4 rg 0.475 0 Td (-)Tj 0.275 0.275 0.263 rg 0.0336 Tc 0.854 0 Td (63%; )Tj 0.196 0.2 0.188 rg 0 Tc -20.278 -1.094 Td (p )Tj 0.408 0.412 0.4 rg 10.6 0 0 10.6 61.39 123.6 Tm (< )Tj ET BT /Suspect <>BDC 0.275 0.275 0.263 rg /T1_0 1 Tf -0.0217 Tc 10.1 0 0 10.1 69.02 123.6 Tm (0.01 )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.9793 0 0 10.1 86.82 123.6 Tm (\). )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.8794 0 0 10.1 105.04 123.6 Tm (TcoiL )Tj EMC ET BT /T1_0 1 Tf 0.0118 Tc 10.1 0 0 10.1 140.08 123.6 Tm (increased )Tj 0.0326 Tc 5.131 0 Td (after )Tj 0.0254 Tc 3.192 0 Td (methacholine )Tj 0.0491 Tc -16.834 -1.092 Td (\(mean:+ )Tj 0.196 0.2 0.188 rg -0.0252 Tc 3.969 0 Td (148%)Tj 0.345 0.349 0.333 rg 0 Tc 2.343 0 Td (; )Tj ET BT /Suspect <>BDC 0.275 0.275 0.263 rg /T1_0 1 Tf 10.1 0 0 10.1 123.3847 112.5708 Tm (p)Tj 0.408 0.412 0.4 rg 0.706 0 Td (<)Tj 0.196 0.2 0.188 rg -0.0114 Tc 0.803 0 Td (0.05\); )Tj EMC ET BT /T1_0 1 Tf 0.0324 Tc 10.1 0 0 10.1 165.0472 112.5708 Tm (it )Tj 0.275 0.275 0.263 rg 0.0146 Tc 0.853 0 Td (diminished )Tj 0.345 0.349 0.333 rg 0.0326 Tc 4.895 0 Td (after )Tj 0.275 0.275 0.263 rg 0.0364 Tc 2.234 0 Td (atropine )Tj -0.035 Tc 9.9195 0 0 10.1 54.16 102 Tm (in )Tj 0.0125 Tc 10.1 0 0 10.1 66.22 102 Tm (three )Tj 0.196 0.2 0.188 rg 0.014 Tc 2.416 0 Td (dogs. )Tj 0.275 0.275 0.263 rg 0.0121 Tc 2.661 0 Td (Cs )Tj 0.0059 Tc 1.475 0 Td (increased )Tj 0.0208 Tc 4.275 0 Td (after )Tj 0.0364 Tc 2.329 0 Td (atropine )Tj 0.0413 Tc 3.943 0 Td (\(p )Tj 0.345 0.349 0.333 rg 0 Tc 1.052 0 Td (< )Tj ET BT /Suspect <>BDC 0.275 0.275 0.263 rg /T1_0 1 Tf -0.006 Tc 10.1 0 0 10.1 257.6554 102 Tm (0.05\), )Tj EMC /Suspect <>BDC 0 Tc 12.5 0 0 12.5 328.64 731.29 Tm (6 )Tj EMC /Suspect <>BDC 0.05 Tc 8.8861 0 0 6.3001 328.74 726.48 Tm (I,. )Tj EMC /Suspect <>BDC 0 Tc 6.3001 0 0 6.3001 344.56 726.48 Tm (6 )Tj EMC ET BT /T1_0 1 Tf 7.7 0 0 7.7 329.72 718.33 Tm (E )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 4.4001 0 0 4.4001 329.72 714.48 Tm (0 )Tj EMC /Suspect <>BDC -0.035 Tc 7.9956 0 0 10.1 328.24 701.53 Tm (0: )Tj EMC /Suspect <>BDC 0.345 0.349 0.333 rg 0 Tc 8 0 0 8 346.91 678.97 Tm (\225 )Tj EMC /Suspect <>BDC 0.408 0.412 0.4 rg /T1_2 1 Tf -0.035 Tc 6.2951 0 0 8 357.49 678.97 Tm (1:6 )Tj EMC /Suspect <>BDC 0.345 0.349 0.333 rg /T1_1 1 Tf 0 Tc 13 0 0 13 370.57 678.97 Tm (A )Tj EMC /Suspect <>BDC 0.408 0.412 0.4 rg /C0_0 1 Tf 2.5601 0 0 9.6 384 678.97 Tm <004A007E00290020>Tj EMC /Suspect <>BDC 0.275 0.275 0.263 rg /T1_0 1 Tf 0.0347 Tc 5.3001 0 0 5.3001 361.42 671.76 Tm (P>BDC 0.345 0.349 0.333 rg /T1_1 1 Tf 4.8001 0 0 4.8001 360.41 568.56 Tm (C )Tj EMC /Suspect <>BDC 0.196 0.2 0.188 rg 2.694 0 Td (M )Tj EMC /Suspect <>BDC 0.345 0.349 0.333 rg /T1_0 1 Tf -0.035 Tc 5.2644 0 0 5.7 337.26 560.41 Tm (1000 )Tj EMC /Suspect <>BDC 0.275 0.275 0.263 rg 0 Tc 12.2 0 0 12.2 330.02 546 Tm (8 )Tj EMC ET BT /T1_0 1 Tf -0.015 Tc 8.3 0 0 8.3 329.68 541.21 Tm (a: )Tj ET BT /Suspect <>BDC /T1_3 1 Tf -0.035 Tc 6.6681 0 0 11.2 442.02 750.48 Tm (bN )Tj EMC /Suspect <>BDC 0.196 0.2 0.188 rg /T1_1 1 Tf 0 Tc 5.5001 0 0 5.5001 441.93 744.24 Tm (I )Tj EMC /Suspect <>BDC 0.275 0.275 0.263 rg /T1_0 1 Tf 12.8 0 0 12.8 443.34 734.65 Tm (5 )Tj EMC /Suspect <>BDC /T1_3 1 Tf 9.9 0 0 9.9 442.41 712.56 Tm (d )Tj EMC /Suspect <>BDC 0.408 0.412 0.4 rg /T1_0 1 Tf 6 0 0 6 447.8 571.44 Tm (I )Tj EMC /Suspect <>BDC 0.275 0.275 0.263 rg -0.035 Tc 4.1385 0 0 6 449.75 571.44 Tm (ZOO )Tj EMC /Suspect <>BDC 0.345 0.349 0.333 rg /T1_1 1 Tf 0.05 Tc 4.7342 0 0 3.2001 440.08 557.53 Tm (\(I\) )Tj EMC /Suspect <>BDC 0.275 0.275 0.263 rg /T1_0 1 Tf 0 Tc 6.4001 0 0 6.4001 439.14 551.76 Tm (0 )Tj EMC /Suspect <>BDC 0.345 0.349 0.333 rg -0.035 Tc 5.7908 0 0 5.8001 447.16 545.05 Tm (1000 )Tj EMC /Suspect <>BDC 0.275 0.275 0.263 rg /T1_1 1 Tf 5.1894 0 0 5.4001 449.22 520.09 Tm (800 )Tj EMC /Suspect <>BDC 0.196 0.2 0.188 rg 4.8609 0 0 5.4001 449.27 470.16 Tm (400 )Tj EMC /Suspect <>BDC /C0_0 1 Tf 0 Tc 28.32 0 0 49.44 472.33 705.36 Tm <007E0020>Tj EMC /Suspect <>BDC 0.275 0.275 0.263 rg /T1_1 1 Tf 4.8001 0 0 4.8001 472.73 695.76 Tm (C )Tj EMC /Suspect <>BDC 0.196 0.2 0.188 rg 2.794 0 Td (M )Tj EMC /Suspect <>BDC 0.275 0.275 0.263 rg 5.5001 0 0 5.5001 500.01 695.29 Tm (I )Tj EMC /Suspect <>BDC 0.408 0.412 0.4 rg /T1_0 1 Tf -0.035 Tc 6.0069 0 0 7.4001 459.72 690.48 Tm (;; )Tj EMC /Suspect <>BDC 0.275 0.275 0.263 rg 7.2738 0 0 7.4001 470.82 689.53 Tm (il'z )Tj EMC /Suspect <>BDC 5.5597 0 0 7.1 483.82 689.53 Tm (40 )Tj EMC /Suspect <>BDC 6.9474 0 0 7.8001 496.72 689.05 Tm (9s )Tj EMC /Suspect <>BDC 0.345 0.349 0.333 rg 0.05 Tc 5.6074 0 0 5.3001 474.22 681.85 Tm (P>BDC -0.0032 Tc 5.4001 0 0 5.4001 449.1 432.72 Tm (100 )Tj EMC /Suspect <>BDC /C0_0 1 Tf 0 Tc 3.6 0 0 6.72 449.29 418.81 Tm <0041004A>Tj 0.09 0.094 0.082 rg 5.5201 0 0 6.72 459.36 418.81 Tm <0074002D>Tj 0.196 0.2 0.188 rg 11.52 0 0 6.72 470.4 418.81 Tm <00B7>Tj 0.09 0.094 0.082 rg 11.36 0 0 6.72 481.93 418.81 Tm <007E002D002D>Tj EMC /Suspect <>BDC 0.549 0.553 0.537 rg /T1_0 1 Tf 5.4001 0 0 5.4001 446.34 409.69 Tm (-)Tj 0.275 0.275 0.263 rg -0.035 Tc 5.2996 0 0 5.4001 449.1 409.69 Tm (100 )Tj EMC ET BT 0.345 0.349 0.333 rg /T1_0 1 Tf 0.0152 Tc 8.2 0 0 8.2 307.17 386.16 Tm (Fig)Tj 0.196 0.2 0.188 rg 0 Tc 1.388 0 Td (. )Tj 0.275 0.275 0.263 rg 0.485 0 Td (4)Tj 0.09 0.094 0.082 rg 0.51 0 Td (. )Tj 0.275 0.275 0.263 rg -0.0107 Tc 1.244 0 Td (Effects )Tj 0.05 Tc 8.9033 0 0 8.2 361.84 386.16 Tm (of )Tj 0.0087 Tc 8.2 0 0 8.2 370.96 386.16 Tm (aerosolized )Tj -0.0035 Tc 4.924 0 Td (mecholyl)Tj 0.408 0.412 0.4 rg 0 Tc 3.733 0 Td (, )Tj 0.275 0.275 0.263 rg -0.0084 Tc 0.59 0 Td (followed )Tj -0.035 Tc 8.0386 0 0 8.2 478.57 386.16 Tm (by )Tj 0.345 0.349 0.333 rg 0.0157 Tc 8.2 0 0 8.2 489.05 386.16 Tm (isoproterenol )Tj 0.275 0.275 0.263 rg 0.0024 Tc -22.244 -1.052 Td (injected )Tj 0.0164 Tc 3.571 0 Td (intravenously )Tj 0.0001 Tc 6.029 0 Td (in )Tj 0.345 0.349 0.333 rg -0.0063 Tc 1.106 0 Td (seven )Tj 0.275 0.275 0.263 rg 0.009 Tc 2.639 0 Td (dogs. )Tj 0.345 0.349 0.333 rg 0 Tc 2.576 0 Td (C )Tj 0.275 0.275 0.263 rg -0.035 Tc 7.8068 0 0 8.2 446.34 377.53 Tm (is )Tj 0.345 0.349 0.333 rg 0.0312 Tc 8.2 0 0 8.2 454 377.53 Tm (control, )Tj 0.275 0.275 0.263 rg 0 Tc 3.693 0 Td (M )Tj -0.035 Tc 7.8068 0 0 8.2 495.3 377.53 Tm (is )Tj -0.0035 Tc 8.2 0 0 8.2 503.5 377.53 Tm (mecholyl )Tj 0.345 0.349 0.333 rg 0.0137 Tc -24.007 -1.112 Td (aerosol, )Tj 0.275 0.275 0.263 rg 0 Tc 3.632 0 Td [(I )-118(i)]TJ 0.408 0.412 0.4 rg 0.929 0 Td [(s )-128(i)]TJ 0.275 0.275 0.263 rg 0.0187 Tc 0.995 0 Td (soproterenol. )Tj 0.0122 Tc 5.926 0 Td (Absolute )Tj 0.0134 Tc 4.03 0 Td (changes )Tj 0.0399 Tc 3.629 0 Td (are )Tj -0.0056 Tc 1.649 0 Td (used )Tj 0.022 Tc 2.213 0 Td (for )Tj 0.196 0.2 0.188 rg -0.035 Tc 7.7501 0 0 8.2 508.77 368.41 Tm (RL )Tj 0.345 0.349 0.333 rg 0.045 Tc 8.2 0 0 8.2 521.2 368.41 Tm (and )Tj -0.035 Tc 8.0313 0 0 8.2 306.64 359.28 Tm (CL, )Tj 0.275 0.275 0.263 rg 0.045 Tc 8.2 0 0 8.2 321.04 359.28 Tm (and )Tj 0.345 0.349 0.333 rg 0 Tc 8.8 0 0 8.8 336.87 359.28 Tm (% )Tj 0.275 0.275 0.263 rg 0.0134 Tc 8.2 0 0 8.2 347.44 359.28 Tm (changes )Tj 0.0093 Tc 3.628 0 Td (from )Tj 0.0058 Tc 2.409 0 Td (the )Tj 0.0113 Tc 1.584 0 Td (previous )Tj 0.0182 Tc 3.918 0 Td (measurement )Tj 0.022 Tc 5.845 0 Td (for )Tj 0.0058 Tc 1.589 0 Td (the )Tj 0.345 0.349 0.333 rg 0.0383 Tc 1.573 0 Td (othe)Tj 0.196 0.2 0.188 rg 0 Tc 1.882 0 Td (r )Tj 0.275 0.275 0.263 rg 0.0151 Tc -27.393 -1.052 Td (parameters: )Tj 0.196 0.2 0.188 rg 0 Tc 5.145 0 Td (R)Tj 0.345 0.349 0.333 rg -0.0034 Tc 0.751 0 Td (saw )Tj 0.275 0.275 0.263 rg 0.045 Tc 1.82 0 Td (and )Tj -0.0133 Tc 1.937 0 Td (Rcoll )Tj 0.0155 Tc 2.454 0 Td (on )Tj 0.0351 Tc 1.354 0 Td (the )Tj -0.0107 Tc 1.574 0 Td (left, )Tj -0.0104 Tc 1.873 0 Td (Tcoll )Tj 0.045 Tc 2.399 0 Td (and )Tj 0.0203 Tc 1.873 0 Td (Cs )Tj 0.0155 Tc 1.346 0 Td (on )Tj 0.0351 Tc 1.354 0 Td (the )Tj 0.0175 Tc 1.582 0 Td (right. )Tj 0.345 0.349 0.333 rg -0.0077 Tc 10.1 0 0 10.1 306.58 320.41 Tm (since )Tj 0.275 0.275 0.263 rg 0 Tc 2.475 0 Td (a )Tj 0.0086 Tc 0.899 0 Td (significant )Tj 0.0127 Tc 4.709 0 Td (decrease )Tj 0.05 Tc 10.5727 0 0 10.1 428.54 320.41 Tm (of )Tj 0.0064 Tc 10.1 0 0 10.1 441.55 320.41 Tm (Rcoll )Tj 0.0255 Tc 2.656 0 Td (accompanied )Tj 0 Tc 5.988 0 Td (a )Tj 0.0134 Tc -22.008 -1.093 Td (smaller )Tj 0.196 0.2 0.188 rg 0.0127 Tc 3.331 0 Td (decrease )Tj 0.275 0.275 0.263 rg 0.05 Tc 11.1292 0 0 10.1 379.57 309.37 Tm (of )Tj 0.0396 Tc 10.1 0 0 10.1 391.59 309.37 Tm (Teo )Tj 0.196 0.2 0.188 rg -0.035 Tc 8.0838 0 0 10.1 408.42 309.37 Tm (II. )Tj 0.0254 Tc 9.5 0 0 9.5 397.88 282 Tm (Discussion )Tj 0.05 Tc 10.2656 0 0 10.1 315.75 265.69 Tm (The )Tj 0.275 0.275 0.263 rg 0.0174 Tc 10.1 0 0 10.1 334.94 265.69 Tm (collateral )Tj 0.0324 Tc 4.194 0 Td (pathways )Tj 0.0093 Tc 4.276 0 Td (between )Tj 0 Tc 3.649 0 Td (a )Tj 0.0276 Tc 0.709 0 Td (segment )Tj 0.0444 Tc 3.711 0 Td (and )Tj 0.0328 Tc 1.861 0 Td (the )Tj 0.0373 Tc -21.255 -1.093 Td (surrounding )Tj 0.09 0.094 0.082 rg 0 Tc 5.565 0 Td (l)Tj 0.275 0.275 0.263 rg 0.0345 Tc 0.247 0 Td (ung )Tj 0.0203 Tc 1.939 0 Td (could )Tj 0.0121 Tc 2.764 0 Td (theoretically )Tj -0.0304 Tc 5.563 0 Td (be )Tj 0.196 0.2 0.188 rg -0.0004 Tc 1.32 0 Td (divid)Tj 0.345 0.349 0.333 rg 0.0272 Tc 2.09 0 Td (ed )Tj 0.275 0.275 0.263 rg 0.0418 Tc 1.334 0 Td (into )Tj 0.0244 Tc -20.81 -1.093 Td (three )Tj 0.0161 Tc 2.325 0 Td (zones)Tj 0.408 0.412 0.4 rg 0 Tc 2.366 0 Td (, )Tj 0.275 0.275 0.263 rg 0.0258 Tc 0.481 0 Td (according )Tj 0.0333 Tc 4.38 0 Td (to )Tj 0.0328 Tc 1.093 0 Td (the )Tj 0.0307 Tc 1.513 0 Td (control )Tj 0.05 Tc 11.1292 0 0 10.1 462.13 243.61 Tm (of )Tj 0.0183 Tc 10.1 0 0 10.1 473.74 243.61 Tm (their )Tj 0.0366 Tc 2.131 0 Td (aperture)Tj 0.09 0.094 0.082 rg 0 Tc 3.553 0 Td (. )Tj 0.275 0.275 0.263 rg 0.0291 Tc -22.325 -1.046 Td (Thei)Tj 0.09 0.094 0.082 rg 0 Tc 1.956 0 Td (r )Tj 0.275 0.275 0.263 rg 0.0259 Tc 0.799 0 Td (calibre )Tj 0.0203 Tc 3.327 0 Td (could )Tj 0.0171 Tc 2.862 0 Td (be )Tj 0.0222 Tc 1.415 0 Td (controlled )Tj 0.0246 Tc 4.751 0 Td (either )Tj 0.0076 Tc 2.911 0 Td (by )Tj 0.0184 Tc 1.518 0 Td (tension )Tj 0.0125 Tc -19.542 -1.093 Td (exerted )Tj -0.035 Tc 10.0482 0 0 10.1 343.69 222.01 Tm (by )Tj -0.0026 Tc 10.1 0 0 10.1 359.89 222.01 Tm (fibres )Tj 0.0113 Tc 2.994 0 Td (from )Tj 0.009 Tc 2.718 0 Td (the )Tj 0.0147 Tc 1.894 0 Td (lung )Tj 0.0373 Tc 2.466 0 Td (surrounding )Tj 0.0328 Tc 5.81 0 Td (the )Tj 0.0066 Tc -21.243 -1.093 Td (wedged )Tj 0.0151 Tc 3.551 0 Td (segment, )Tj -0.013 Tc 4.186 0 Td (as )Tj -0.0005 Tc 1.285 0 Td (in )Tj 0.0202 Tc 1.186 0 Td (case )Tj 0.05 Tc 11.1292 0 0 10.1 430.93 210.97 Tm (of )Tj 0.0306 Tc 10.1 0 0 10.1 443.91 210.97 Tm (lung )Tj 0.0035 Tc 2.288 0 Td (vo)Tj 0.09 0.094 0.082 rg 0 Tc 1.039 0 Td (l)Tj 0.275 0.275 0.263 rg 0.0195 Tc 0.247 0 Td (ume )Tj 0.0444 Tc 2.224 0 Td (and )Tj 0.196 0.2 0.188 rg -0.035 Tc 9.4653 0 0 10.1 522.68 210.97 Tm (PL )Tj 0.275 0.275 0.263 rg 0.0135 Tc 10.1 0 0 10.1 305.66 199.93 Tm (changes)Tj 0.408 0.412 0.4 rg 0 Tc 3.321 0 Td (, )Tj 0.275 0.275 0.263 rg -0.035 Tc 10.0482 0 0 10.1 346.09 199.93 Tm (by )Tj 0.0184 Tc 10.1 0 0 10.1 359.5 199.93 Tm (tension )Tj 0.0125 Tc 3.365 0 Td (exerted )Tj 0.0076 Tc 3.386 0 Td (by )Tj 0.0306 Tc 1.368 0 Td (lung )Tj -0.0216 Tc 2.232 0 Td (fibres )Tj 0.0131 Tc 2.576 0 Td (within )Tj 0.009 Tc 3.041 0 Td (the )Tj 0.0066 Tc -21.29 -1.093 Td (wedged )Tj 0.0083 Tc 3.409 0 Td (segment, )Tj 0.05 Tc 10.5727 0 0 10.1 380.06 188.89 Tm (or )Tj -0.01 Tc 10.1 0 0 10.1 392.05 188.89 Tm (finally )Tj -0.035 Tc 10.0482 0 0 10.1 421.45 188.89 Tm (by )Tj 0.0184 Tc 10.1 0 0 10.1 433.9 188.89 Tm (tension )Tj 0.0131 Tc 3.28 0 Td (within )Tj 0.196 0.2 0.188 rg 0.009 Tc 2.946 0 Td (the )Tj 0.275 0.275 0.263 rg -0.0031 Tc 1.522 0 Td (walls )Tj 0.05 Tc 11.1292 0 0 10.1 305.65 177.85 Tm (of )Tj 0.0328 Tc 10.1 0 0 10.1 317.26 177.85 Tm (the )Tj 0.0264 Tc 1.465 0 Td (channels)Tj 0.408 0.412 0.4 rg 0 Tc 3.744 0 Td (. )Tj 0.275 0.275 0.263 rg 0.05 Tc 10.2656 0 0 10.1 374.31 177.85 Tm (The )Tj -0.0026 Tc 10.1 0 0 10.1 393.49 177.85 Tm (fibres )Tj 0.05 Tc 11.1292 0 0 10.1 418.93 177.85 Tm (of )Tj 0.0328 Tc 10.1 0 0 10.1 430.54 177.85 Tm (the )Tj -0.0031 Tc 1.522 0 Td (walls )Tj 0.05 Tc 11.1292 0 0 10.1 469.81 177.85 Tm (of )Tj 0.009 Tc 10.1 0 0 10.1 481.42 177.85 Tm (the )Tj 0.0196 Tc 1.513 0 Td (channels )Tj 0.0299 Tc -18.962 -1.046 Td (can )Tj 0.0171 Tc 1.912 0 Td (be )Tj 0.0211 Tc 1.368 0 Td (located )Tj 0.0179 Tc 3.47 0 Td (intrasegmentally, )Tj 0.0136 Tc 7.604 0 Td (intersegmentally )Tj 0.05 Tc 10.5727 0 0 10.1 524.06 167.29 Tm (or )Tj 0.345 0.349 0.333 rg 10.7518 0 0 10.1 305.65 156.25 Tm (at )Tj 0.275 0.275 0.263 rg 0.009 Tc 10.1 0 0 10.1 321.58 156.25 Tm (the )Tj 0.345 0.349 0.333 rg 0.0254 Tc 1.94 0 Td (external )Tj 0.275 0.275 0.263 rg 0.0291 Tc 4.136 0 Td (opening )Tj 0.05 Tc 11.1292 0 0 10.1 424.21 156.25 Tm (of )Tj 0.009 Tc 10.1 0 0 10.1 440.62 156.25 Tm (the )Tj 0.0196 Tc 1.988 0 Td (channels )Tj -0.035 Tc 9.9195 0 0 10.1 504.88 156.25 Tm (in )Tj 0.0328 Tc 10.1 0 0 10.1 520.3 156.25 Tm (the )Tj 0.0326 Tc -21.255 -1.093 Td (surrounding )Tj 0.196 0.2 0.188 rg 0.0306 Tc 5.423 0 Td (lung)Tj 0.345 0.349 0.333 rg 0 Tc 1.889 0 Td (. )Tj 0.196 0.2 0.188 rg 0.0257 Tc 0.44 0 Td (These )Tj 0.275 0.275 0.263 rg 0.0183 Tc 2.756 0 Td (last )Tj -0.0121 Tc 1.709 0 Td (fibres )Tj 0.0376 Tc 2.52 0 Td (are )Tj 0.345 0.349 0.333 rg 0.0392 Tc 1.517 0 Td (su)Tj 0.196 0.2 0.188 rg 0.0152 Tc 0.966 0 Td (pposed )Tj 0.275 0.275 0.263 rg -0.0143 Tc 3.275 0 Td (to )Tj -0.0304 Tc 1.096 0 Td (be )Tj 0.009 Tc -21.579 -1.094 Td (the )Tj 0.035 Tc 1.663 0 Td (most )Tj 0.0118 Tc 2.364 0 Td (sensitive )Tj 0.05 Tc 10.4772 0 0 10.1 385.89 134.16 Tm (to )Tj 0.0328 Tc 10.1 0 0 10.1 398.38 134.16 Tm (the )Tj 0.0073 Tc 1.655 0 Td (aerosolized )Tj 0.0245 Tc 5.046 0 Td (mecho)Tj 0.09 0.094 0.082 rg 0 Tc 2.797 0 Td (l)Tj 0.275 0.275 0.263 rg 0.246 0 Td (y)Tj 0.09 0.094 0.082 rg 0.515 0 Td (l )Tj 0.275 0.275 0.263 rg -0.0153 Tc 0.626 0 Td (which )Tj 0.008 Tc -20.055 -1.046 Td (reaches )Tj 0.0164 Tc 3.413 0 Td (only )Tj 0.0328 Tc 2.194 0 Td (the )Tj 0.0111 Tc 1.664 0 Td (non-wedged )Tj -0.0039 Tc 5.457 0 Td (lung. )Tj ET BT /Suspect <>BDC 0.196 0.2 0.188 rg /T1_0 1 Tf 0.05 Tc 10.6396 0 0 10.1 315.25 112.08 Tm (Of )Tj EMC ET BT 0.275 0.275 0.263 rg /T1_0 1 Tf 0.0181 Tc 10.1 0 0 10.1 333.5 112.08 Tm (course, )Tj 0.0328 Tc 3.762 0 Td (the )Tj 0.0114 Tc 2.045 0 Td (resistance )Tj 0.05 Tc 11.1292 0 0 10.1 440.53 112.08 Tm (of )Tj 0.0328 Tc 10.1 0 0 10.1 456.94 112.08 Tm (the )Tj 0.0226 Tc 1.988 0 Td (airways )Tj 0.0444 Tc 3.945 0 Td (and )Tj 0.345 0.349 0.333 rg 0.0275 Tc -20.958 -1.046 Td (co)Tj 0.196 0.2 0.188 rg 0.024 Tc (llat)Tj 0.345 0.349 0.333 rg 0.042 Tc 2.328 0 Td (era)Tj 0.196 0.2 0.188 rg 0 Tc 1.333 0 Td (l )Tj 0.275 0.275 0.263 rg 0.0324 Tc 0.581 0 Td (pathways )Tj 0.05 Tc 11.1292 0 0 10.1 391.57 101.52 Tm (of )Tj 0.0328 Tc 10.1 0 0 10.1 404.14 101.52 Tm (the )Tj 0.345 0.349 0.333 rg 0.0432 Tc 1.604 0 Td (sur)Tj 0.196 0.2 0.188 rg 0.0275 Tc 1.344 0 Td (rounding )Tj 0.275 0.275 0.263 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/Im8 Do Q q 17.2799988 0 0 33.6000061 574.5599976 536.1600037 cm /Im9 Do Q q 16.3200073 0 0 25.9199982 574.5599976 505.4400024 cm /Im10 Do Q q 21.1199951 0 0 68.1600037 570.7200012 424.8000031 cm /Im11 Do Q q 25.9199982 0 0 31.6799927 563.0399933 378.7200012 cm /Im12 Do Q q 22.0800018 0 0 29.7599945 566.8800049 348 cm /Im13 Do Q q 18.2400055 0 0 60.4799957 570.7200012 282.7200012 cm /Im14 Do Q q 18.2400055 0 0 33.6000061 570.7200012 205.9199982 cm /Im15 Do Q q 25.9199982 0 0 43.1999969 563.0399933 152.1600037 cm /Im16 Do Q q 41.2799988 0 0 56.6399994 547.6799927 21.6000061 cm /Im17 Do Q q 66.7200012 0 0 24 0 23.5200043 cm /Im18 Do Q q 17.2799988 0 0 13.4400024 129.1199951 26.3999939 cm /Im19 Do Q BT /Suspect <>BDC 0.251 0.251 0.239 rg /T1_0 1 Tf 0.05 Tc 3 Tr 8.5887 0 0 7.8001 159.34 777.36 Tm (AEROSOLIZED )Tj EMC /Suspect <>BDC 0 Tc 7.8001 0 0 7.8001 227.49 777.36 Tm (M)Tj 0.149 0.153 0.141 rg 0.983 0 Td (E)Tj 0.251 0.251 0.239 rg 0.672 0 Td (C)Tj 0.149 0.153 0.141 rg 0.868 0 Td (H)Tj 0.251 0.251 0.239 rg 0.05 Tc 8.5968 0 0 7.8001 253.83 777.36 Tm (OLYL )Tj EMC ET BT /T1_0 1 Tf 8.4949 0 0 7.8001 282.71 777.36 Tm (AND )Tj 0.31 0.31 0.302 rg 8.7381 0 0 7.8001 306.15 777.36 Tm (COLLATERAL )Tj ET BT /Suspect <>BDC 0.251 0.251 0.239 rg /T1_0 1 Tf 0 Tc 7.8001 0 0 7.8001 371.49 777.36 Tm (R)Tj 0.376 0.376 0.369 rg 0.86 0 Td (E)Tj 0.251 0.251 0.239 rg 0.05 Tc 8.6751 0 0 7.8001 383.36 777.36 Tm (SISTANCE )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 9.5245 0 0 10.1 517.86 777.36 Tm (221 )Tj ET BT /Suspect <>BDC /T1_1 1 Tf -0.0316 Tc 5.7 0 0 5.7 77.65 742.33 Tm (rn )Tj EMC ET BT /T1_0 1 Tf 0 Tc 6.8001 0 0 6.8001 86.76 742.33 Tm (8 )Tj ET BT /Suspect <>BDC /C0_0 1 Tf 35.0401 0 0 50.88 108 702 Tm <007E0020>Tj EMC /Suspect <>BDC 0.31 0.31 0.302 rg /T1_2 1 Tf 11.2 0 0 11.2 181.33 739.44 Tm (b )Tj EMC /Suspect <>BDC 0.471 0.471 0.459 rg /C0_0 1 Tf 2.88 0 0 2.88 76.81 738.48 Tm <007E0020>Tj EMC /Suspect <>BDC 0.251 0.251 0.239 rg /T1_1 1 Tf -0.035 Tc 5.4264 0 0 10.5 185.62 736.56 Tm (... )Tj EMC /Suspect <>BDC 0 Tc 5.6 0 0 5.6 181.29 732.24 Tm (I )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.0297 Tc 7.4001 0 0 7.4001 76.24 726.48 Tm (0,.)Tj 0.149 0.153 0.141 rg 0 Tc 1.426 0 Td (6 )Tj EMC /Suspect <>BDC 0.251 0.251 0.239 rg 8 0 0 8 182.36 726 Tm (E)Tj 0.149 0.153 0.141 rg -0.035 Tc 7.1724 0 0 8 190.95 726 Tm (600 )Tj EMC /Suspect <>BDC 0.251 0.251 0.239 rg /T1_1 1 Tf 0 Tc 5.6 0 0 5.6 75.69 720.24 Tm (I )Tj EMC /Suspect <>BDC 0.31 0.31 0.302 rg /T1_3 1 Tf 0.05 Tc 6.5935 0 0 3.6 182.27 723.12 Tm (\(\) )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0 Tc 10.2 0 0 10.2 76.57 712.09 Tm (\247 )Tj EMC ET BT 0.149 0.153 0.141 rg /T1_0 1 Tf 7.3001 0 0 7.3001 86.37 712.09 Tm (4 )Tj ET BT /Suspect <>BDC 0.31 0.31 0.302 rg /T1_0 1 Tf 14.2 0 0 14.2 181.29 714 Tm (e )Tj EMC /Suspect <>BDC 0.471 0.471 0.459 rg -0.035 Tc 5.9993 0 0 7.8001 182.42 707.76 Tm (_.)Tj 0.251 0.251 0.239 rg 7.1252 0 0 7.8001 191.01 707.76 Tm (400 )Tj EMC /Suspect <>BDC 0.31 0.31 0.302 rg /T1_2 1 Tf 8.5656 0 0 9.7 74.74 697.21 Tm (ct )Tj EMC /Suspect <>BDC 0.251 0.251 0.239 rg /T1_1 1 Tf 0.05 Tc 8.3856 0 0 4.7 180.81 701.53 Tm (\(\) )Tj EMC /Suspect <>BDC 0.149 0.153 0.141 rg /C0_0 1 Tf 0 Tc 34.08 0 0 15.84 108 684.24 Tm <007E0020>Tj EMC /Suspect <>BDC 0.251 0.251 0.239 rg /T1_1 1 Tf -0.035 Tc 6.1016 0 0 7 190.99 694.8 Tm (200 )Tj EMC /Suspect <>BDC /T1_2 1 Tf 12.7806 0 0 15.3 105.39 667.92 Tm (I:. )Tj EMC /Suspect <>BDC 0.149 0.153 0.141 rg /T1_1 1 Tf 0 Tc 17.4 0 0 17.4 125.05 665.53 Tm (" )Tj EMC /Suspect <>BDC 6.2 0 0 6.2 138.73 673.68 Tm (A )Tj EMC ET BT 0.31 0.31 0.302 rg /T1_0 1 Tf 9.8 0 0 9.8 216.38 673.68 Tm (c )Tj ET BT /Suspect <>BDC 0.149 0.153 0.141 rg /T1_1 1 Tf 6.2 0 0 6.2 233.15 673.21 Tm (M )Tj EMC /Suspect <>BDC 0.251 0.251 0.239 rg 6.1 0 0 6.1 249.61 673.68 Tm (A )Tj EMC /Suspect <>BDC 6.8001 0 0 6.8001 92.03 667.92 Tm (i )Tj EMC /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.9061 0 0 8.8 123.75 667.44 Tm (Tf.Z )Tj EMC /Suspect <>BDC 7.2643 0 0 6.9001 230.32 666.97 Tm (-5)Tj 0.149 0.153 0.141 rg -0.0243 Tc 6.9001 0 0 6.9001 236.88 666.97 Tm (11 )Tj EMC /Suspect <>BDC 0.251 0.251 0.239 rg 0.0117 Tc 1.41 0 Td (\2252281 )Tj EMC /Suspect <>BDC 0.05 Tc 7.1086 0 0 6.9001 116.61 659.76 Tm (<0.02<0.05 )Tj EMC /Suspect <>BDC /C0_0 1 Tf 0 Tc 3.9361 0 0 5.28 224.17 659.29 Tm <007E0030002E003000350020>Tj EMC /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 5.1473 0 0 6.2 252.85 658.33 Tm (NS )Tj EMC /Suspect <>BDC 9.977 0 0 11 74.75 615.61 Tm ("' )Tj EMC /Suspect <>BDC 6.38 0 0 6.5001 190.06 615.61 Tm (400 )Tj EMC /Suspect <>BDC 0.31 0.31 0.302 rg /T1_0 1 Tf 0.0463 Tc 4.7 0 0 4.7 73.35 612.24 Tm (.:.. )Tj EMC /Suspect <>BDC 0.376 0.376 0.369 rg 0 Tc 1.94 0 Td (.)Tj 0.251 0.251 0.239 rg 0.515 0 Td ($)Tj 0.149 0.153 0.141 rg 0.813 0 Td (. )Tj EMC /Suspect <>BDC 0.31 0.31 0.302 rg 0.0345 Tc 41.4001 0 0 41.4001 107.51 585.85 Tm (\\_ )Tj EMC ET BT 0.251 0.251 0.239 rg /T1_1 1 Tf 0 Tc 7.2 0 0 7.2 74.23 606.48 Tm (E )Tj ET BT /Suspect <>BDC 0.376 0.376 0.369 rg /T1_0 1 Tf 7.8001 0 0 7.8001 184.24 605.05 Tm (0 )Tj EMC /Suspect <>BDC 0.251 0.251 0.239 rg 7.6 0 0 7.6 72.88 600.24 Tm (0 )Tj EMC /Suspect <>BDC 6.9001 0 0 6.9001 84.4 600.24 Tm (6 )Tj EMC /Suspect <>BDC /T1_2 1 Tf 0.05 Tc 6.7153 0 0 3.2001 185.11 602.17 Tm (\(\) )Tj EMC /Suspect <>BDC /T1_0 1 Tf 9.8932 0 0 6.4001 72.89 593.53 Tm (I" )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 7.8345 0 0 8.4 184.24 596.89 Tm (a: )Tj ET BT /Suspect <>BDC /T1_1 1 Tf 10.7619 0 0 12.4 73.31 583.92 Tm (8.4 )Tj EMC /Suspect <>BDC /T1_0 1 Tf 6.8033 0 0 6.9001 189.56 584.41 Tm (200 )Tj EMC /Suspect <>BDC /C0_0 1 Tf 0 Tc 4.32 0 0 4.8 73.44 571.92 Tm <007E0020>Tj EMC /Suspect <>BDC 4.8 0 0 7.2 72.96 564.73 Tm <007E0020>Tj EMC ET BT /T1_0 1 Tf 6.9001 0 0 6.9001 84.44 568.56 Tm (2 )Tj -0.0232 Tc 8.4 0 0 8.4 71.44 559.44 Tm (a: )Tj ET BT /Suspect <>BDC 0.31 0.31 0.302 rg /T1_0 1 Tf 0 Tc 6.9001 0 0 6.9001 83.93 553.68 Tm (0 )Tj EMC /Suspect <>BDC 0.149 0.153 0.141 rg /C0_0 1 Tf 5.28 0 0 5.76 184.33 553.68 Tm <007E>Tj 0.251 0.251 0.239 rg 4.5601 0 0 5.76 190.09 553.68 Tm <0073006F0020>Tj EMC ET BT /T1_0 1 Tf 10.3 0 0 10.3 106.94 545.53 Tm (c )Tj 0.149 0.153 0.141 rg /T1_1 1 Tf 6.1 0 0 6.1 123.7 546 Tm (H )Tj ET BT /Suspect <>BDC 0.251 0.251 0.239 rg /T1_1 1 Tf 6.2 0 0 6.2 137.29 546 Tm (A )Tj EMC /Suspect <>BDC -0.035 Tc 5.152 0 0 6.1 121.32 539.76 Tm (HS )Tj EMC /Suspect <>BDC 0.149 0.153 0.141 rg 0 Tc 6.1 0 0 6.1 137.62 539.76 Tm (H)Tj 0.251 0.251 0.239 rg 0.639 0 Td (S )Tj EMC /Suspect <>BDC 0.376 0.376 0.369 rg /T1_0 1 Tf 6.7 0 0 6.7 185.68 540.73 Tm (-)Tj 0.149 0.153 0.141 rg 0.551 0 Td (1)Tj 0.251 0.251 0.239 rg 0.0246 Tc 0.382 0 Td (00 )Tj EMC ET BT /T1_3 1 Tf 0 Tc 10.2 0 0 10.2 218.32 533.53 Tm (c )Tj ET BT /Suspect <>BDC 0.149 0.153 0.141 rg /T1_1 1 Tf 6.2 0 0 6.2 231.71 533.53 Tm (M )Tj EMC /Suspect <>BDC 6.1 0 0 6.1 248.17 534 Tm (A )Tj EMC /Suspect <>BDC 0.251 0.251 0.239 rg /T1_0 1 Tf 0.0199 Tc 6.9001 0 0 6.9001 225.49 525.85 Tm (\225861 )Tj EMC /Suspect <>BDC 0.0231 Tc 2.37 0 Td (-631 )Tj EMC /Suspect <>BDC -0.035 Tc 5.0199 0 0 6.9001 226.1 515.76 Tm (NS )Tj EMC /Suspect <>BDC 0.05 Tc 7.676 0 0 6.9001 235.64 515.76 Tm (<0.01 )Tj EMC ET BT 0.149 0.153 0.141 rg /T1_1 1 Tf 0 Tc 6.5001 0 0 6.5001 83.5 485.53 Tm (4 )Tj ET BT /Suspect <>BDC 0.251 0.251 0.239 rg /T1_2 1 Tf 0.0381 Tc 72 0 0 72 105.04 436.56 Tm (li )Tj EMC /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 7.0907 0 0 9.1 72.77 471.61 Tm (:g )Tj EMC ET BT /T1_0 1 Tf 0 Tc 6.8001 0 0 6.8001 82.96 471.61 Tm (3 )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0099 Tc 6.7 0 0 6.7 188.13 469.69 Tm (400 )Tj EMC /Suspect <>BDC /C0_0 1 Tf 0 Tc 6.24 0 0 7.2 72 462.97 Tm <007E0020>Tj EMC /Suspect <>BDC /T1_2 1 Tf 6.5001 0 0 6.5001 82.99 453.84 Tm (l )Tj EMC /Suspect <>BDC /T1_1 1 Tf -0.035 Tc 9.977 0 0 11.9 184.67 452.89 Tm ("' )Tj EMC /Suspect <>BDC 0.05 Tc 8.3856 0 0 4.7 183.21 453.84 Tm (\(\) )Tj EMC /Suspect <>BDC -0.035 Tc 6.1016 0 0 7 188.11 438.49 Tm (200 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 10.3 0 0 10.3 105.5 415.44 Tm (c )Tj ET BT /Suspect <>BDC 0.149 0.153 0.141 rg /T1_1 1 Tf 6.8001 0 0 6.8001 121.77 414.97 Tm (M )Tj EMC /Suspect <>BDC /T1_0 1 Tf 7.2 0 0 7.2 138.71 414.97 Tm (A )Tj EMC ET BT 0.251 0.251 0.239 rg /T1_0 1 Tf -0.035 Tc 9.3645 0 0 9.8 110.35 406.81 Tm (>BDC 0.149 0.153 0.141 rg /T1_1 1 Tf 0 Tc 6.2 0 0 6.2 136.18 407.28 Tm (N)Tj 0.251 0.251 0.239 rg 0.552 0 Td (S )Tj EMC /Suspect <>BDC 0.149 0.153 0.141 rg /T1_0 1 Tf -0.035 Tc 6.5956 0 0 8.7 189.59 405.84 Tm (AS )Tj EMC /Suspect <>BDC 0.251 0.251 0.239 rg 0.028 Tc 7.1 0 0 7.1 185.68 390 Tm (-100 )Tj EMC ET BT /T1_0 1 Tf 0 Tc 10.3 0 0 10.3 217.34 393.84 Tm (c )Tj ET BT /Suspect <>BDC 0.149 0.153 0.141 rg /T1_1 1 Tf 6.8001 0 0 6.8001 233.61 394.33 Tm (M )Tj EMC /Suspect <>BDC /T1_0 1 Tf 7.2 0 0 7.2 247.67 393.84 Tm (A )Tj EMC /Suspect <>BDC 9.8 0 0 9.8 231.4 385.69 Tm (N)Tj 0.251 0.251 0.239 rg -0.035 Tc 9.1477 0 0 9.8 234.55 385.69 Tm (S<)Tj 0.149 0.153 0.141 rg 6.2968 0 0 9.8 244.74 385.69 Tm (O.)Tj 0.251 0.251 0.239 rg 5.5049 0 0 9.8 251.47 385.69 Tm (OS )Tj EMC ET BT 0.31 0.31 0.302 rg /T1_0 1 Tf -0.0015 Tc 8.3 0 0 8.3 52.76 371.28 Tm (Fig. )Tj 0.251 0.251 0.239 rg 0 Tc 1.842 0 Td (5)Tj 0.376 0.376 0.369 rg 0.513 0 Td (. )Tj 0.31 0.31 0.302 rg -0.0226 Tc 1.229 0 Td (Effect )Tj 0.376 0.376 0.369 rg 0 Tc 2.657 0 Td (o)Tj 0.251 0.251 0.239 rg 0.519 0 Td (f )Tj -0.0026 Tc 0.58 0 Td (aerosolized )Tj -0.0099 Tc 4.923 0 Td (mecholyl )Tj 0.31 0.31 0.302 rg -0.0145 Tc 3.982 0 Td (followed )Tj 0.251 0.251 0.239 rg -0.0073 Tc 3.829 0 Td (by )Tj -0.0121 Tc 7.7 0 0 7.7 229.86 371.28 Tm (i. )Tj /T1_3 1 Tf 0 Tc 8.7 0 0 8.7 234.67 371.28 Tm (v)Tj 0.376 0.376 0.369 rg 0.383 0 Td (. )Tj 0.251 0.251 0.239 rg /T1_0 1 Tf 0.0297 Tc 8.3 0 0 8.3 242.32 371.28 Tm (atropine )Tj -0.035 Tc 7.9356 0 0 8.3 273.54 371.28 Tm (in )Tj 0.31 0.31 0.302 rg 0.0166 Tc 8.3 0 0 8.3 52.23 362.16 Tm (four )Tj 0.251 0.251 0.239 rg 0.0095 Tc 2.199 0 Td (dogs)Tj 0.376 0.376 0.369 rg 0 Tc 1.955 0 Td (. )Tj 0.251 0.251 0.239 rg 0.002 Tc 0.71 0 Td (Panels )Tj 0.0358 Tc 3.06 0 Td (and )Tj 0.31 0.31 0.302 rg 0.0112 Tc 1.974 0 Td (values )Tj 0.251 0.251 0.239 rg 0.0465 Tc 3 0 Td (as )Tj 0.31 0.31 0.302 rg -0.009 Tc 1.331 0 Td (in )Tj -0.0068 Tc 1.212 0 Td (figure )Tj -0.035 Tc 7.5461 0 0 8.3 203.97 362.16 Tm (4. )Tj 0.251 0.251 0.239 rg 0 Tc 8.3 0 0 8.3 213.52 362.16 Tm (C )Tj 0.376 0.376 0.369 rg -0.0137 Tc 1.158 0 Td (is )Tj 0.31 0.31 0.302 rg 0.0173 Tc 1.098 0 Td (control, )Tj 0.251 0.251 0.239 rg 0 Tc 3.706 0 Td (M )Tj 0.31 0.31 0.302 rg -0.0137 Tc 1.384 0 Td (is )Tj 0.251 0.251 0.239 rg -0.0038 Tc -26.77 -1.098 Td (mecholyl, )Tj 0.0358 Tc 4.214 0 Td (and )Tj 0 Tc 1.859 0 Td (A )Tj -0.035 Tc 7.8068 0 0 8.3 111.3 353.05 Tm (is )Tj 0.0214 Tc 8.3 0 0 8.3 118.96 353.05 Tm (atropine)Tj 0.376 0.376 0.369 rg 0 Tc 3.459 0 Td (. )Tj 0.251 0.251 0.239 rg 0.0126 Tc 0.536 0 Td (Rsaw )Tj -0.0137 Tc 2.541 0 Td (is )Tj -0.0087 Tc 0.923 0 Td (expres)Tj 0.376 0.376 0.369 rg -0.035 Tc 8.0856 0 0 8.3 202.45 353.05 Tm (se)Tj 0.251 0.251 0.239 rg 0 Tc 8.3 0 0 8.3 208.72 353.05 Tm (d )Tj 0.31 0.31 0.302 rg -0.035 Tc 7.9356 0 0 8.3 215.94 353.05 Tm (in )Tj ET BT /Suspect <>BDC 0.251 0.251 0.239 rg /T1_0 1 Tf 0.0222 Tc 8.3 0 0 8.3 224.56 353.05 Tm (cmH)Tj 0.376 0.376 0.369 rg 0 Tc 5.2 0 0 5.2 241.89 351.12 Tm (2)Tj 8.3 0 0 8.3 245.2 353.05 Tm (0)Tj 0.251 0.251 0.239 rg 0.0344 Tc 0.857 0 Td (\267mt)Tj 0.376 0.376 0.369 rg 0 Tc 1.512 0 Td (-)Tj 0.251 0.251 0.239 rg 0.05 Tc 9.0783 0 0 8.3 270.1 353.05 Tm (\225\267s )Tj EMC ET BT 0.31 0.31 0.302 rg /T1_0 1 Tf 0.0358 Tc 8.3 0 0 8.3 52.24 344.41 Tm (and )Tj 0.251 0.251 0.239 rg 0 Tc 1.852 0 Td (T)Tj 0.376 0.376 0.369 rg 0.05 Tc 8.387 0 0 8.3 72.4 344.41 Tm (co)Tj 0.251 0.251 0.239 rg -0.035 Tc 7.6228 0 0 8.3 81.06 344.41 Tm (ll )Tj -0.009 Tc 8.3 0 0 8.3 87.77 344.41 Tm (in )Tj 0.31 0.31 0.302 rg -0.035 Tc 8.2938 0 0 8.3 96.84 344.41 Tm (s. )Tj 0.251 0.251 0.239 rg 0.0103 Tc 10.1 0 0 10.1 52.24 316.56 Tm (increase)Tj 0.376 0.376 0.369 rg 0 Tc 3.319 0 Td (, )Tj 0.251 0.251 0.239 rg 0.05 Tc 10.18 0 0 10.1 92.17 316.56 Tm (but )Tj -0.005 Tc 10.1 0 0 10.1 109.9 316.56 Tm (this )Tj 0.0114 Tc 1.759 0 Td (resistance )Tj 0.035 Tc 4.419 0 Td (must )Tj 0.0171 Tc 2.379 0 Td (be )Tj 0.31 0.31 0.302 rg 0.0121 Tc 1.268 0 Td (small )Tj 0.251 0.251 0.239 rg 0.0055 Tc 2.581 0 Td (because )Tj 0.05 Tc 11.1292 0 0 10.1 270.61 316.56 Tm (of )Tj 0.009 Tc 10.1 0 0 10.1 52.3 305.53 Tm (the )Tj 0.0081 Tc 1.561 0 Td (la)Tj 0.149 0.153 0.141 rg 0 Tc 0.721 0 Td (r)Tj 0.251 0.251 0.239 rg -0.0253 Tc 0.372 0 Td (ge )Tj 0.0262 Tc 1.187 0 Td (cross)Tj 0.149 0.153 0.141 rg 0 Tc 2.184 0 Td (-)Tj 0.251 0.251 0.239 rg 0.0145 Tc 0.283 0 Td (sectio)Tj 0.149 0.153 0.141 rg 0 Tc 2.437 0 Td (n)Tj 0.251 0.251 0.239 rg 0.0039 Tc 0.514 0 Td (al )Tj 0.0358 Tc 1.046 0 Td (area )Tj 0.05 Tc 10.5727 0 0 10.1 177.5 305.53 Tm (of )Tj -0.0015 Tc 10.1 0 0 10.1 189.1 305.53 Tm (these )Tj 0.0108 Tc 2.368 0 Td (airways, )Tj 0.0444 Tc 3.754 0 Td (and )Tj 0.0118 Tc 1.855 0 Td (its )Tj 0.0009 Tc -21.529 -1.093 Td (influence )Tj 0.0184 Tc 4.133 0 Td (on )Tj 0.009 Tc 1.529 0 Td (the )Tj 0.31 0.31 0.302 rg 0.0186 Tc 1.655 0 Td (collatera)Tj 0.149 0.153 0.141 rg 0 Tc 3.66 0 Td (l )Tj 0.251 0.251 0.239 rg -0.0309 Tc 0.663 0 Td (flow )Tj -0.0085 Tc 2.245 0 Td (used )Tj 0.0192 Tc 2.279 0 Td (must )Tj 0.0171 Tc 2.474 0 Td (be )Tj 0.007 Tc 1.423 0 Td (trivial )Tj 0.31 0.31 0.302 rg 0.0042 Tc -20.115 -1.094 Td (since )Tj 0.251 0.251 0.239 rg 0.0109 Tc 2.341 0 Td (this )Tj -0.032 Tc 1.752 0 Td (is )Tj -0.004 Tc 0.909 0 Td (very )Tj 0.149 0.153 0.141 rg 0 Tc 2.037 0 Td (l)Tj 0.31 0.31 0.302 rg -0.0135 Tc 0.284 0 Td (ow )Tj 0.251 0.251 0.239 rg 0 Tc 1.459 0 Td ([)Tj 0.149 0.153 0.141 rg 0.369 0 Td (1)Tj 0.251 0.251 0.239 rg -0.035 Tc 9.1759 0 0 10.1 148.96 283.44 Tm (1\). )Tj 0.0122 Tc 10.1 0 0 10.1 161.26 283.44 Tm (Afte)Tj 0.149 0.153 0.141 rg 0 Tc 1.854 0 Td (r )Tj 0.251 0.251 0.239 rg 0.609 0 Td (a )Tj 0.0322 Tc 0.771 0 Td (bronchoco)Tj 0.149 0.153 0.141 rg 0 Tc 4.513 0 Td (n)Tj 0.31 0.31 0.302 rg 0.0336 Tc 0.51 0 Td (strict)Tj 0.149 0.153 0.141 rg 0 Tc 2.145 0 Td (i)Tj 0.251 0.251 0.239 rg 0.0013 Tc 0.292 0 Td (ng )Tj 0.0319 Tc -21.538 -1.092 Td (aeroso)Tj 0.149 0.153 0.141 rg 0 Tc 2.805 0 Td (l)Tj 0.251 0.251 0.239 rg (, )Tj 0.0445 Tc 1.103 0 Td (both )Tj 0.0174 Tc 2.46 0 Td (collateral )Tj 0.0444 Tc 4.467 0 Td (and )Tj 0.0194 Tc 2.139 0 Td (airway )Tj -0.0121 Tc 3.431 0 Td (res)Tj 0.149 0.153 0.141 rg 0 Tc 1.181 0 Td (i)Tj 0.31 0.31 0.302 rg 0.0226 Tc 0.232 0 Td (stances )Tj ET BT /Suspect <>BDC 0.251 0.251 0.239 rg /T1_0 1 Tf -0.0004 Tc 10.1 0 0 10.1 268.2392 272.4108 Tm (in\255)Tj EMC ET BT /T1_0 1 Tf 0.009 Tc 10.1 0 0 10.1 51.7356 261.8361 Tm (crease)Tj 0.376 0.376 0.369 rg 0 Tc 2.56 0 Td (, )Tj 0.251 0.251 0.239 rg 0.05 Tc 10.18 0 0 10.1 82.57 261.84 Tm (but )Tj 0.149 0.153 0.141 rg 0 Tc 10.1 0 0 10.1 99.79 261.84 Tm (R)Tj 0.251 0.251 0.239 rg -0.0012 Tc 0.708 0 Td (coll )Tj -0.0093 Tc 1.72 0 Td (will )Tj 0.0082 Tc 1.75 0 Td (always )Tj 0.0348 Tc 3.05 0 Td (remain )Tj 0.0225 Tc 3.184 0 Td (higher )Tj 0.0213 Tc 2.901 0 Td (because )Tj -0.0119 Tc 3.508 0 Td (its )Tj 0.31 0.31 0.302 rg 0.0373 Tc -21.63 -1.093 Td (starting )Tj 0.251 0.251 0.239 rg 0.013 Tc 3.719 0 Td (va)Tj 0.149 0.153 0.141 rg 0 Tc 1.039 0 Td (l)Tj 0.251 0.251 0.239 rg -0.0004 Tc 0.247 0 Td (ues )Tj 0.0376 Tc 1.796 0 Td (are )Tj 0.03 Tc 1.757 0 Td [(far )-192(more )]TJ 0.039 Tc 4.28 0 Td (imp)Tj 0.149 0.153 0.141 rg 0 Tc 1.661 0 Td (o)Tj 0.251 0.251 0.239 rg 0.05 Tc 10.4055 0 0 10.1 202.55 250.8 Tm (rtant )Tj -0.035 Tc 9.7837 0 0 10.1 228.24 250.8 Tm ([2\). )Tj 0.0242 Tc 10.1 0 0 10.1 246.62 250.8 Tm (Closure )Tj 0.0444 Tc -19.295 -1.093 Td (and )Tj 0.0067 Tc 2.282 0 Td (gas )Tj 0.31 0.31 0.302 rg 0.0382 Tc 2.146 0 Td (trappi)Tj 0.149 0.153 0.141 rg 0 Tc 2.567 0 Td (n)Tj 0.251 0.251 0.239 rg 0.515 0 Td (g )Tj 0.0299 Tc 1.235 0 Td (can )Tj 0.0325 Tc 2.234 0 Td (occur)Tj 0.376 0.376 0.369 rg 0 Tc 2.37 0 Td (, )Tj 0.251 0.251 0.239 rg -0.035 Tc 9.9195 0 0 10.1 196.72 239.76 Tm (in )Tj 0.0287 Tc 10.1 0 0 10.1 212.65 239.76 Tm (both )Tj 0.0227 Tc 2.65 0 Td (collateral )Tj 0.0316 Tc -18.57 -1.092 Td (path)Tj 0.149 0.153 0.141 rg 0 Tc 1.85 0 Td (w)Tj 0.31 0.31 0.302 rg 0.0049 Tc 0.751 0 Td (ays )Tj 0.251 0.251 0.239 rg 0 Tc 1.758 0 Td (a)Tj 0.149 0.153 0.141 rg 0.532 0 Td (n)Tj 0.251 0.251 0.239 rg 0.514 0 Td (d )Tj 0.31 0.31 0.302 rg 0.0328 Tc 0.958 0 Td (the )Tj 0.251 0.251 0.239 rg 0 Tc 1.699 0 Td (s)Tj 0.149 0.153 0.141 rg 0.392 0 Td (m)Tj 0.251 0.251 0.239 rg 0.006 Tc 0.8 0 Td (all )Tj 0.0226 Tc 1.426 0 Td (airways )Tj 0.31 0.31 0.302 rg 0.05 Tc 11.1292 0 0 10.1 196.69 228.73 Tm (of )Tj 0.009 Tc 10.1 0 0 10.1 209.74 228.73 Tm (the )Tj 0.0416 Tc 1.699 0 Td (surroun)Tj 0.149 0.153 0.141 rg 0 Tc 3.331 0 Td (d)Tj 0.251 0.251 0.239 rg 0.0349 Tc 0.525 0 Td (ing )Tj -0.0039 Tc -21.197 -1.093 Td (lung. )Tj -0.035 Tc 9.4309 0 0 10.1 75.19 217.69 Tm (Si)Tj 0.149 0.153 0.141 rg 0 Tc 10.1 0 0 10.1 83.99 217.69 Tm (n)Tj 0.251 0.251 0.239 rg 0.037 Tc 0.466 0 Td (ce )Tj 0 Tc 1.149 0 Td (t)Tj 0.149 0.153 0.141 rg 0.334 0 Td (h)Tj 0.251 0.251 0.239 rg 0.0095 Tc 0.561 0 Td (ose )Tj 0.0171 Tc 1.625 0 Td (had )Tj 0 Tc 1.797 0 Td (a )Tj 0.0219 Tc 0.721 0 Td (much )Tj 0.022 Tc 2.607 0 Td (larger )Tj 0.0386 Tc 2.66 0 Td (control )Tj 0.0114 Tc 3.383 0 Td (resistance )Tj 0.31 0.31 0.302 rg 0.05 Tc 10.4772 0 0 10.1 51.33 207.13 Tm (to )Tj 0.251 0.251 0.239 rg -0.0309 Tc 10.1 0 0 10.1 62.77 207.13 Tm (flow)Tj 0.376 0.376 0.369 rg 0 Tc 1.801 0 Td (, )Tj 0.251 0.251 0.239 rg 0.0136 Tc 0.537 0 Td (they )Tj 0.0376 Tc 2.036 0 Td (are )Tj 0.0301 Tc 1.58 0 Td (probably )Tj 0.0206 Tc 4.037 0 Td (where )Tj 0.31 0.31 0.302 rg 0.009 Tc 2.803 0 Td (the )Tj 0.251 0.251 0.239 rg 0.0201 Tc 1.568 0 Td (ma)Tj 0.149 0.153 0.141 rg 0 Tc 1.277 0 Td (i)Tj 0.251 0.251 0.239 rg 0.292 0 Td (n )Tj 0.0215 Tc 0.751 0 Td (closure )Tj 0.05 Tc 10.1505 0 0 10.1 263.9 207.13 Tm (can )Tj 0.014 Tc 10.1 0 0 10.1 51.26 196.09 Tm (occur. )Tj 0.0149 Tc 2.818 0 Td (Nevertheless)Tj 0.376 0.376 0.369 rg 0 Tc 5.35 0 Td (, )Tj 0.251 0.251 0.239 rg 0.0183 Tc 0.477 0 Td (some )Tj 0.0243 Tc 2.38 0 Td (closu)Tj 0.149 0.153 0.141 rg 0 Tc 2.243 0 Td (r)Tj 0.251 0.251 0.239 rg 0.323 0 Td (e )Tj -0.0005 Tc 0.668 0 Td (in )Tj 0.009 Tc 1.099 0 Td (the )Tj 0.0121 Tc 1.509 0 Td (small )Tj 0.0147 Tc 2.475 0 Td (airways )Tj 0.31 0.31 0.302 rg 0.0207 Tc -19.343 -1.093 Td (and )Tj 0.251 0.251 0.239 rg 0.0071 Tc 1.901 0 Td (colla)Tj 0.149 0.153 0.141 rg 0 Tc 2.051 0 Td (t)Tj 0.251 0.251 0.239 rg 0.0307 Tc 0.276 0 Td (eral )Tj 0.0257 Tc 1.961 0 Td (pathways )Tj 0.31 0.31 0.302 rg 0.0131 Tc 4.322 0 Td (within )Tj 0.251 0.251 0.239 rg 0.0328 Tc 3.041 0 Td (the )Tj 0.31 0.31 0.302 rg 0 Tc 1.604 0 Td (s)Tj 0.149 0.153 0.141 rg 0.394 0 Td (u)Tj 0.251 0.251 0.239 rg 0.569 0 Td (r)Tj 0.149 0.153 0.141 rg 0.38 0 Td (r)Tj 0.251 0.251 0.239 rg 0.05 Tc 10.2564 0 0 10.1 221.66 185.05 Tm (ou)Tj 0.149 0.153 0.141 rg 0.0013 Tc 10.1 0 0 10.1 232.79 185.05 Tm (nd)Tj 0.251 0.251 0.239 rg 0.0112 Tc 1.086 0 Td (ing )Tj 0.0147 Tc 1.662 0 Td (lung )Tj 0.037 Tc -20.769 -1.093 Td (ca)Tj 0.149 0.153 0.141 rg 0 Tc 0.959 0 Td (n)Tj 0.251 0.251 0.239 rg 0.05 Tc 10.1333 0 0 10.1 66.23 174.01 Tm (not )Tj 0.0171 Tc 10.1 0 0 10.1 84.01 174.01 Tm (be )Tj 0.0037 Tc 1.319 0 Td (excluded)Tj 0.376 0.376 0.369 rg 0 Tc 3.702 0 Td (, )Tj 0.251 0.251 0.239 rg 0.0255 Tc 0.624 0 Td (and, )Tj 0.31 0.31 0.302 rg -0.0005 Tc 2.188 0 Td (in )Tj 0.251 0.251 0.239 rg 0.05 Tc 10.5338 0 0 10.1 174.62 174.01 Tm (our )Tj 0.0311 Tc 10.1 0 0 10.1 192.85 174.01 Tm (experimenta)Tj 0.149 0.153 0.141 rg 0 Tc 5.277 0 Td (l )Tj 0.31 0.31 0.302 rg 0.0257 Tc 0.569 0 Td (condi\255)Tj 0.0086 Tc -19.857 -1.093 Td (tions, )Tj 0.251 0.251 0.239 rg 0.0104 Tc 2.661 0 Td (these )Tj -0.002 Tc 2.52 0 Td (ways )Tj 0.035 Tc 2.423 0 Td (must )Tj 0.0171 Tc 2.427 0 Td (be )Tj 0.0177 Tc 1.32 0 Td (considered )Tj -0.013 Tc 4.895 0 Td (as )Tj 0.0395 Tc 1.248 0 Td (parts )Tj 0.31 0.31 0.302 rg 0.05 Tc 11.1292 0 0 10.1 253.33 162.97 Tm (of )Tj 0.0328 Tc 10.1 0 0 10.1 265.9 162.97 Tm (the )Tj 0.0275 Tc -21.299 -1.046 Td (co)Tj 0.149 0.153 0.141 rg -0.035 Tc 9.5285 0 0 10.1 60.88 152.41 Tm (ll)Tj 0.251 0.251 0.239 rg 0.0248 Tc 10.1 0 0 10.1 66.14 152.41 Tm (ateral )Tj 0.0324 Tc 2.721 0 Td (pathways )Tj 0.05 Tc 11.1292 0 0 10.1 136.69 152.41 Tm (of )Tj 0.31 0.31 0.302 rg 0.009 Tc 10.1 0 0 10.1 149.26 152.41 Tm (the )Tj 0.251 0.251 0.239 rg 0.0309 Tc 1.56 0 Td (obstructed )Tj 0.0197 Tc 4.749 0 Td (segment )Tj 0.0444 Tc 3.758 0 Td (and )Tj 0.0333 Tc 1.909 0 Td (to )Tj 0.149 0.153 0.141 rg 0 Tc -21.725 -1.093 Td (i)Tj 0.251 0.251 0.239 rg -0.002 Tc 0.292 0 Td (nfluence )Tj -0.0279 Tc 3.794 0 Td (TcoiJ )Tj 0.0444 Tc 2.518 0 Td (and )Tj -0.0001 Tc 1.901 0 Td (Cs. )Tj 0 Tc -7.501 -1.093 Td (A )Tj -0.0253 Tc 1.039 0 Td (ge)Tj 0.149 0.153 0.141 rg 0 Tc 0.958 0 Td (n)Tj 0.251 0.251 0.239 rg 0.465 0 Td (e)Tj 0.149 0.153 0.141 rg 0.485 0 Td (r)Tj 0.251 0.251 0.239 rg 0.0009 Tc 0.419 0 Td (alized )Tj 0.0352 Tc 2.767 0 Td (bronchoconstr)Tj 0.149 0.153 0.141 rg 0 Tc 6.122 0 Td (i)Tj 0.251 0.251 0.239 rg 0.0285 Tc 0.236 0 Td (ction )Tj 0.0155 Tc 2.426 0 Td (is )Tj 0.0218 Tc 0.996 0 Td (also )Tj 0.0272 Tc 1.948 0 Td (ex)Tj 0.149 0.153 0.141 rg 0 Tc 1.011 0 Td (p)Tj 0.251 0.251 0.239 rg 0.0131 Tc 0.51 0 Td (ected )Tj 0.0333 Tc -20.379 -1.094 Td (to )Tj 0.0171 Tc 1.372 0 Td (increase )Tj 0.0328 Tc 3.903 0 Td (the )Tj 0.05 Tc 10.146 0 0 10.1 122.84 119.28 Tm (FRC, )Tj 0.0316 Tc 10.1 0 0 10.1 151.69 119.28 Tm (but )Tj 0.31 0.31 0.302 rg 0.0156 Tc 1.886 0 Td (such )Tj 0.251 0.251 0.239 rg 0.0185 Tc 2.428 0 Td (an )Tj 0.0103 Tc 1.57 0 Td (increase )Tj 0.0326 Tc 3.844 0 Td (should )Tj 0.0127 Tc -19.766 -1.092 Td (decrease )Tj 0.0328 Tc 3.81 0 Td (the )Tj 0.0064 Tc 1.613 0 Td (Rcoll )Tj 0.0076 Tc 2.525 0 Td (by )Tj 0.018 Tc 1.272 0 Td (acting )Tj 0 Tc 2.804 0 Td (o)Tj 0.149 0.153 0.141 rg 0.579 0 Td (n )Tj 0.31 0.31 0.302 rg 0.0328 Tc 0.807 0 Td (the )Tj 0.0031 Tc 1.568 0 Td (tens)Tj 0.149 0.153 0.141 rg 0 Tc 1.657 0 Td (i)Tj 0.251 0.251 0.239 rg 0.05 Tc 10.2564 0 0 10.1 221.18 108.25 Tm (on )Tj 0.31 0.31 0.302 rg 0.0125 Tc 10.1 0 0 10.1 234.61 108.25 Tm (exerted )Tj 0.251 0.251 0.239 rg -0.035 Tc 10.0482 0 0 10.1 268.81 108.25 Tm (by )Tj -0.0216 Tc 10.1 0 0 10.1 50.77 97.2 Tm (fibres )Tj 0.05 Tc 10.2264 0 0 10.1 76.69 97.2 Tm (from )Tj 0.009 Tc 10.1 0 0 10.1 102.22 97.2 Tm (the )Tj 0.31 0.31 0.302 rg 0.0432 Tc 1.604 0 Td (sur)Tj 0.149 0.153 0.141 rg 0 Tc 1.344 0 Td (r)Tj 0.251 0.251 0.239 rg 0.0434 Tc 0.324 0 Td (ounding )Tj -0.0039 Tc 3.898 0 Td (lung. )Tj 0.0123 Tc 2.415 0 Td (Since )Tj -0.035 Tc 9.8086 0 0 10.1 225.59 97.2 Tm (we )Tj 0.017 Tc 10.1 0 0 10.1 240.38 97.2 Tm (observed )Tj 0.009 Tc 6.471 65.015 Td (the )Tj 0.0026 Tc 1.569 0 Td (reverse)Tj 0.376 0.376 0.369 rg 0 Tc 2.884 0 Td (, )Tj 0.251 0.251 0.239 rg 0.0109 Tc 0.632 0 Td (this )Tj 0.0141 Tc 1.806 0 Td (mechanism )Tj 0.026 Tc 4.982 0 Td (does )Tj 0.05 Tc 10.1333 0 0 10.1 448.31 753.85 Tm (not )Tj 0.31 0.31 0.302 rg -0.0102 Tc 10.1 0 0 10.1 465.46 753.85 Tm (seem )Tj 0.251 0.251 0.239 rg 0.0333 Tc 2.436 0 Td (to )Tj 0 Tc 1.144 0 Td (b)Tj 0.149 0.153 0.141 rg 0.511 0 Td (e )Tj 0.251 0.251 0.239 rg -0.0345 Tc 0.769 0 Td (ve)Tj 0.149 0.153 0.141 rg 0 Tc 0.951 0 Td (r)Tj 0.251 0.251 0.239 rg 0.38 0 Td (y )Tj 0.0177 Tc -22.011 -1.094 Td (impo)Tj 0.149 0.153 0.141 rg 0 Tc 2.146 0 Td (r)Tj 0.251 0.251 0.239 rg 0.05 Tc 10.215 0 0 10.1 331.18 742.8 Tm (tant )Tj -0.0005 Tc 10.1 0 0 10.1 352.24 742.8 Tm (in )Tj 0.05 Tc 10.5338 0 0 10.1 364.7 742.8 Tm (our )Tj -0.0043 Tc 10.1 0 0 10.1 383.89 742.8 Tm (expe)Tj 0.149 0.153 0.141 rg -0.035 Tc 10.0227 0 0 10.1 403.19 742.8 Tm (ri)Tj 0.251 0.251 0.239 rg 0.0327 Tc 10.1 0 0 10.1 409.42 742.8 Tm (menta)Tj 0.149 0.153 0.141 rg 0 Tc 2.654 0 Td (l )Tj 0.251 0.251 0.239 rg 0.0217 Tc 0.664 0 Td (conditions. )Tj 0.05 Tc 10.943 0 0 10.1 494.45 742.8 Tm (No )Tj 10.2128 0 0 10.1 512.54 742.8 Tm (drug )Tj 0.0299 Tc 10.1 0 0 10.1 305.18 731.76 Tm (can )Tj -0.0304 Tc 1.817 0 Td (be )Tj 0.0118 Tc 1.224 0 Td (expected )Tj 0.0333 Tc 4.001 0 Td (to )Tj 0.0309 Tc 1.145 0 Td (penetrate )Tj 0.31 0.31 0.302 rg 0.009 Tc 4.273 0 Td (the )Tj 0.251 0.251 0.239 rg 0 Tc 1.56 0 Td (o)Tj 0.149 0.153 0.141 rg 0.581 0 Td (b)Tj 0.251 0.251 0.239 rg 0.0279 Tc 0.508 0 Td (structe)Tj 0.149 0.153 0.141 rg 0 Tc 2.808 0 Td (d )Tj 0.251 0.251 0.239 rg 0.0197 Tc 0.899 0 Td (segment)Tj 0.376 0.376 0.369 rg 0 Tc 3.467 0 Td (, )Tj 0.251 0.251 0.239 rg 0.0136 Tc -22.227 -1.045 Td (neither )Tj 0.0333 Tc 3.326 0 Td (th)Tj 0.149 0.153 0.141 rg 0 Tc 0.904 0 Td (r)Tj 0.251 0.251 0.239 rg 0.0372 Tc 0.324 0 Td (ough )Tj 0.009 Tc 2.622 0 Td (the )Tj 0.0066 Tc 1.712 0 Td (wedged )Tj 0.0345 Tc 3.614 0 Td (bronchus)Tj 0.376 0.376 0.369 rg 0 Tc 3.975 0 Td (, )Tj 0.251 0.251 0.239 rg 0.05 Tc 10.4078 0 0 10.1 479.03 721.21 Tm (nor )Tj 0 Tc 10.1 0 0 10.1 498.7 721.21 Tm (t)Tj 0.149 0.153 0.141 rg 0.334 0 Td (h)Tj 0.251 0.251 0.239 rg 0.05 Tc 10.332 0 0 10.1 507.35 721.21 Tm (ro)Tj 0.149 0.153 0.141 rg 0 Tc 10.1 0 0 10.1 516.96 721.21 Tm (u)Tj 0.251 0.251 0.239 rg 0.0127 Tc 0.514 0 Td (gh )Tj 0.009 Tc -21.427 -1.093 Td (the )Tj 0.0227 Tc 1.846 0 Td (collateral )Tj 0.31 0.31 0.302 rg 0.0196 Tc 4.562 0 Td (channels )Tj 0.251 0.251 0.239 rg 0.0014 Tc 4.286 0 Td (whe)Tj 0.149 0.153 0.141 rg 0 Tc 1.711 0 Td (r)Tj 0.251 0.251 0.239 rg 0.323 0 Td [(e )-400(a )]TJ 0.0433 Tc 2.235 0 Td (constant )Tj 0.0238 Tc 4.23 0 Td (outflow )Tj 0.0286 Tc -19.24 -1.094 Td (through )Tj 0.31 0.31 0.302 rg 0.009 Tc 3.945 0 Td (the )Tj 0.376 0.376 0.369 rg 0.0275 Tc 1.798 0 Td (co)Tj 0.251 0.251 0.239 rg -0.035 Tc 7.6228 0 0 10.1 373.86 699.12 Tm (ll)Tj 0.376 0.376 0.369 rg 0.0418 Tc 10.1 0 0 10.1 378.62 699.12 Tm (ate)Tj 0.251 0.251 0.239 rg 0 Tc 1.292 0 Td (r)Tj 0.376 0.376 0.369 rg 0.0039 Tc 0.324 0 Td (al )Tj 0.251 0.251 0.239 rg 0.0025 Tc 1.386 0 Td (ventil)Tj 0.376 0.376 0.369 rg 0.0433 Tc 2.273 0 Td (atio)Tj 0.251 0.251 0.239 rg 0 Tc 1.625 0 Td (n )Tj 0.31 0.31 0.302 rg 0.0222 Tc 1.132 0 Td (avoids )Tj 0.376 0.376 0.369 rg 0.0275 Tc 3.279 0 Td (co)Tj 0.251 0.251 0.239 rg -0.035 Tc 9.5285 0 0 10.1 502.96 699.12 Tm (ll)Tj 0.376 0.376 0.369 rg 0.0418 Tc 10.1 0 0 10.1 508.7 699.12 Tm (ate)Tj 0.251 0.251 0.239 rg 0 Tc 1.292 0 Td (r)Tj 0.376 0.376 0.369 rg 0.324 0 Td (a)Tj 0.251 0.251 0.239 rg 0.524 0 Td (l )Tj 0.0199 Tc -22.278 -1.046 Td (penet)Tj 0.149 0.153 0.141 rg 0 Tc 2.278 0 Td (r)Tj 0.251 0.251 0.239 rg 0.05 Tc 10.1194 0 0 10.1 332.06 688.56 Tm (at)Tj 0.149 0.153 0.141 rg 0 Tc 10.1 0 0 10.1 340.24 688.56 Tm (i)Tj 0.31 0.31 0.302 rg 0.0184 Tc 0.283 0 Td (on )Tj 0.376 0.376 0.369 rg 0.05 Tc 11.1292 0 0 10.1 356.53 688.56 Tm (of )Tj 0.251 0.251 0.239 rg 0.009 Tc 10.1 0 0 10.1 368.62 688.56 Tm (the )Tj 0.0271 Tc 1.513 0 Td (dru)Tj 0.376 0.376 0.369 rg 0 Tc 1.474 0 Td (g )Tj 0.0275 Tc 0.759 0 Td (co)Tj 0.251 0.251 0.239 rg 0.0138 Tc 1.006 0 Td (ming )Tj -0.0199 Tc 2.415 0 Td (fr)Tj 0.376 0.376 0.369 rg 0 Tc 0.666 0 Td (o)Tj 0.251 0.251 0.239 rg 0.578 0 Td (m )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0143 Tc 10.1 0 0 10.1 464.6104 688.56 Tm (th)Tj 0.376 0.376 0.369 rg 0 Tc 0.847 0 Td (e )Tj EMC ET BT /T1_0 1 Tf 10.1 0 0 10.1 480.3361 688.56 Tm (s)Tj 0.251 0.251 0.239 rg 0.0351 Tc 0.442 0 Td (urr)Tj 0.376 0.376 0.369 rg 0 Tc 1.226 0 Td (o)Tj 0.251 0.251 0.239 rg 0.0131 Tc 0.628 0 Td (undin)Tj 0.376 0.376 0.369 rg 0 Tc 2.367 0 Td (g )Tj 0.251 0.251 0.239 rg 0.008 Tc -22.004 -1.092 Td (lung, )Tj 0.05 Tc 10.4078 0 0 10.1 330.23 677.53 Tm (nor )Tj 0.376 0.376 0.369 rg -0.0143 Tc 10.1 0 0 10.1 349.42 677.53 Tm (th)Tj 0.251 0.251 0.239 rg 0 Tc 0.856 0 Td (r)Tj 0.376 0.376 0.369 rg 0.371 0 Td (o)Tj 0.251 0.251 0.239 rg 0.58 0 Td (u)Tj 0.376 0.376 0.369 rg 0.466 0 Td (g)Tj 0.251 0.251 0.239 rg 0.578 0 Td (h )Tj 0.376 0.376 0.369 rg 0.0058 Tc 0.843 0 Td (syste)Tj 0.251 0.251 0.239 rg -0.004 Tc 2.055 0 Td (mi)Tj 0.376 0.376 0.369 rg 0 Tc 1.038 0 Td (c )Tj 0.31 0.31 0.302 rg 0.0251 Tc 0.864 0 Td (resorption )Tj 0.376 0.376 0.369 rg 0.05 Tc 11.1292 0 0 10.1 474.61 677.53 Tm (of )Tj ET BT /Suspect <>BDC 0.31 0.31 0.302 rg /T1_0 1 Tf 0.026 Tc 10.1 0 0 10.1 487.66 677.53 Tm (methacho\255)Tj EMC ET BT 0.251 0.251 0.239 rg /T1_0 1 Tf 0.013 Tc 10.1 0 0 10.1 304.7086 666.4806 Tm (line )Tj 0.31 0.31 0.302 rg -0.0077 Tc 1.896 0 Td (since )Tj 0.251 0.251 0.239 rg -0.0031 Tc 2.436 0 Td (thi)Tj 0.376 0.376 0.369 rg 0 Tc 1.129 0 Td (s )Tj 0.149 0.153 0.141 rg 0.766 0 Td (i)Tj 0.376 0.376 0.369 rg 0.184 0 Td (s )Tj -0.035 Tc 10.0514 0 0 10.1 377.68 666.48 Tm (im)Tj 0.251 0.251 0.239 rg 0 Tc 10.1 0 0 10.1 388.3 666.48 Tm (m)Tj 0.376 0.376 0.369 rg 0.0216 Tc 0.799 0 Td (ediate)Tj 0.251 0.251 0.239 rg 0 Tc 2.521 0 Td (l)Tj 0.376 0.376 0.369 rg 0.246 0 Td (y )Tj 0.0227 Tc 0.847 0 Td (catabolized )Tj 0.31 0.31 0.302 rg -0.035 Tc 9.9195 0 0 10.1 485.2 666.48 Tm (in )Tj 0.0328 Tc 10.1 0 0 10.1 497.26 666.48 Tm (the )Tj 0.251 0.251 0.239 rg 0.0107 Tc 1.656 0 Td (lun)Tj 0.376 0.376 0.369 rg 0 Tc 1.331 0 Td (g )Tj 0.31 0.31 0.302 rg -22.007 -1.093 Td (\()Tj 0.149 0.153 0.141 rg 0.357 0 Td (1)Tj 0.251 0.251 0.239 rg -0.035 Tc 9.657 0 0 10.1 312.42 655.44 Tm (2]. )Tj 0.0362 Tc 10.1 0 0 10.1 325.83 655.44 Tm (Thus )Tj -0.02 Tc 2.432 0 Td (we )Tj 0.0489 Tc 1.417 0 Td (cou)Tj 0.149 0.153 0.141 rg 0 Tc 1.522 0 Td (l)Tj 0.251 0.251 0.239 rg 0.237 0 Td (d )Tj 0.05 Tc 10.1333 0 0 10.1 391.67 655.44 Tm (not )Tj 0.015 Tc 10.1 0 0 10.1 408.37 655.44 Tm (expect )Tj 0.0444 Tc 2.948 0 Td (any )Tj 0.0275 Tc 1.853 0 Td (change )Tj 0.05 Tc 11.1292 0 0 10.1 489.97 655.44 Tm (of )Tj 0.0031 Tc 10.1 0 0 10.1 502.06 655.44 Tm (tens)Tj 0.149 0.153 0.141 rg 0 Tc 1.657 0 Td (i)Tj 0.251 0.251 0.239 rg 0.0184 Tc 0.283 0 Td (on )Tj 0.0141 Tc -21.432 -1.045 Td (induced )Tj 0.0076 Tc 3.811 0 Td (by )Tj 0.0379 Tc 1.565 0 Td (met)Tj 0.149 0.153 0.141 rg 0 Tc 1.569 0 Td (h)Tj 0.251 0.251 0.239 rg 0.0207 Tc 0.514 0 Td (acholine )Tj 0.0252 Tc 4.086 0 Td (for )Tj 0.31 0.31 0.302 rg 0.009 Tc 1.815 0 Td (the )Tj 0.251 0.251 0.239 rg -0.0026 Tc 1.797 0 Td (fibres )Tj 0.0226 Tc 2.814 0 Td (within )Tj 0.0328 Tc 3.231 0 Td (the )Tj 0.0256 Tc -21.204 -1.093 Td (obstructed )Tj -0.002 Tc 4.749 0 Td (segme)Tj 0.149 0.153 0.141 rg 0 Tc 2.579 0 Td (n)Tj 0.251 0.251 0.239 rg -0.0019 Tc 0.522 0 Td (t. )Tj -0.0011 Tc -6.892 -1.094 Td (We )Tj 0.0192 Tc 1.759 0 Td (must )Tj 0.0136 Tc 2.376 0 Td (then )Tj 0.0241 Tc 2.131 0 Td (conclude )Tj 0.05 Tc 10.215 0 0 10.1 419.5 622.8 Tm (that )Tj 0.31 0.31 0.302 rg 0.0328 Tc 10.1 0 0 10.1 440.14 622.8 Tm (the )Tj 0.251 0.251 0.239 rg 0.0223 Tc 1.608 0 Td (constricti)Tj 0.149 0.153 0.141 rg 0 Tc 3.953 0 Td (n)Tj 0.251 0.251 0.239 rg 0.515 0 Td (g )Tj -0.0037 Tc 0.806 0 Td (effect )Tj 0.0238 Tc -20.292 -1.093 Td (observed )Tj 0.0184 Tc 4.23 0 Td (on )Tj 0.0304 Tc 1.521 0 Td (collatera)Tj 0.149 0.153 0.141 rg 0 Tc 3.66 0 Td (l )Tj 0.251 0.251 0.239 rg 0.0324 Tc 0.724 0 Td (pathways )Tj 0 Tc 4.457 0 Td (i)Tj 0.149 0.153 0.141 rg 0.292 0 Td (n )Tj 0.251 0.251 0.239 rg 0.0109 Tc 0.997 0 Td (this )Tj 0.0205 Tc 1.987 0 Td (experiment )Tj 0.0093 Tc -17.87 -1.045 Td (\(increase )Tj -0.035 Tc 9.2018 0 0 10.1 344.6 601.21 Tm (Rco11\) )Tj -0.0144 Tc 10.1 0 0 10.1 372.95 601.21 Tm (was )Tj 0 Tc 1.846 0 Td (l)Tj 0.376 0.376 0.369 rg 0.0247 Tc 0.237 0 Td (ocated )Tj 0.05 Tc 11.3843 0 0 10.1 424.2 601.21 Tm (at )Tj 0 Tc 10.1 0 0 10.1 435.34 601.21 Tm (t)Tj 0.251 0.251 0.239 rg 0.334 0 Td (h)Tj 0.376 0.376 0.369 rg 0.513 0 Td (e )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0283 Tc 10.1 0 0 10.1 450.6112 601.21 Tm (externa)Tj 0.251 0.251 0.239 rg 0 Tc 3.186 0 Td (l )Tj EMC ET BT 0.31 0.31 0.302 rg /T1_0 1 Tf 0.0252 Tc 10.1 0 0 10.1 487.1934 601.21 Tm (way )Tj 0.251 0.251 0.239 rg 0.05 Tc 10.261 0 0 10.1 506.78 601.21 Tm (out )Tj 11.1292 0 0 10.1 523.57 601.21 Tm (of )Tj 0.009 Tc 10.1 0 0 10.1 305.26 590.17 Tm (the )Tj 0.0189 Tc 1.62 0 Td (pathways)Tj 0.149 0.153 0.141 rg 0 Tc 3.969 0 Td (. )Tj 0.251 0.251 0.239 rg 0.0313 Tc 0.535 0 Td (This )Tj 0.31 0.31 0.302 rg 0.0203 Tc (could )Tj -0.0304 Tc 4.905 0 Td (be )Tj 0.0068 Tc 1.329 0 Td (related )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0143 Tc 10.1 0 0 10.1 462.7089 590.17 Tm (to )Tj EMC ET BT 0.376 0.376 0.369 rg /T1_0 1 Tf 0 Tc 10.1 0 0 10.1 474.1522 590.17 Tm (a )Tj 0.31 0.31 0.302 rg 0.0224 Tc 0.808 0 Td (direct )Tj 0.251 0.251 0.239 rg -0.0037 Tc 2.708 0 Td (effect )Tj 0.05 Tc 11.1292 0 0 10.1 304.69 579.12 Tm (of )Tj 0.0322 Tc 10.1 0 0 10.1 322.58 579.12 Tm (parasympathetic )Tj 0.376 0.376 0.369 rg 0.05 Tc 11.1184 0 0 10.1 402.08 579.12 Tm (st)Tj 0.251 0.251 0.239 rg -0.0188 Tc 10.1 0 0 10.1 409.84 579.12 Tm (imul)Tj 0.376 0.376 0.369 rg 0.0433 Tc 1.851 0 Td (atio)Tj 0.251 0.251 0.239 rg 0 Tc 1.672 0 Td (n )Tj 0.376 0.376 0.369 rg 1.417 0 Td (o)Tj 0.251 0.251 0.239 rg 0.569 0 Td (f )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0143 Tc 10.1 0 0 10.1 478.5301 579.12 Tm (th)Tj 0.376 0.376 0.369 rg 0 Tc 0.799 0 Td (e )Tj EMC ET BT 0.31 0.31 0.302 rg /T1_0 1 Tf 0.049 Tc 10.1 0 0 10.1 500.0128 579.12 Tm (smoot)Tj 0.149 0.153 0.141 rg 0 Tc 2.674 0 Td (h )Tj 0.251 0.251 0.239 rg -22.005 -1.092 Td (m)Tj 0.149 0.153 0.141 rg 0.81 0 Td (u)Tj 0.251 0.251 0.239 rg -0.0156 Tc 0.509 0 Td (scles )Tj 0.05 Tc 11.1292 0 0 10.1 341.17 568.09 Tm (of )Tj 0.0109 Tc 10.1 0 0 10.1 354.22 568.09 Tm (this )Tj 0.05 Tc 10.2008 0 0 10.1 373.46 568.09 Tm (part )Tj 0.376 0.376 0.369 rg 11.1292 0 0 10.1 394.93 568.09 Tm (of )Tj 0.31 0.31 0.302 rg 0.0328 Tc 10.1 0 0 10.1 407.98 568.09 Tm (the )Tj 0.376 0.376 0.369 rg 0.0275 Tc 1.655 0 Td (co)Tj 0.251 0.251 0.239 rg -0.035 Tc 9.5285 0 0 10.1 434.8 568.09 Tm (ll)Tj 0.376 0.376 0.369 rg 0.0418 Tc 10.1 0 0 10.1 440.06 568.09 Tm (ate)Tj 0.251 0.251 0.239 rg 0 Tc 1.292 0 Td (r)Tj 0.376 0.376 0.369 rg 0.324 0 Td (a)Tj 0.251 0.251 0.239 rg 0.571 0 Td (l )Tj 0.376 0.376 0.369 rg -0.02 Tc 0.617 0 Td (ch)Tj 0.251 0.251 0.239 rg 0.0022 Tc 0.998 0 Td (annels. )Tj 0.0354 Tc 3.287 0 Td (As )Tj 0 Tc 1.56 0 Td (a )Tj 0.0191 Tc -22.099 -1.046 Td (consequence)Tj 0.376 0.376 0.369 rg 0 Tc 5.317 0 Td (, )Tj 0.251 0.251 0.239 rg 0.584 0 Td (t)Tj 0.149 0.153 0.141 rg 0.334 0 Td (h)Tj 0.251 0.251 0.239 rg 0.513 0 Td (e )Tj 0.0114 Tc 0.769 0 Td (time )Tj 0.0433 Tc 2.131 0 Td (constant )Tj 0.0032 Tc 3.944 0 Td (fo)Tj 0.149 0.153 0.141 rg 0 Tc 0.913 0 Td (r )Tj 0.251 0.251 0.239 rg 0.0174 Tc 0.656 0 Td (collateral )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0132 Tc 10.1 0 0 10.1 500.1449 557.5254 Tm (ventila\255)Tj EMC ET BT /T1_0 1 Tf 0.0214 Tc 10.1 0 0 10.1 304.7806 546.476 Tm (tion )Tj 0.0159 Tc 1.99 0 Td (inc)Tj 0.149 0.153 0.141 rg 0 Tc 1.243 0 Td (r)Tj 0.251 0.251 0.239 rg 0.0042 Tc 0.37 0 Td (ease)Tj 0.149 0.153 0.141 rg 0 Tc 1.759 0 Td (d)Tj 0.31 0.31 0.302 rg 0.559 0 Td (. )Tj 0.251 0.251 0.239 rg 0.0095 Tc 0.573 0 Td (Si)Tj 0.149 0.153 0.141 rg 0 Tc 0.872 0 Td (n)Tj 0.251 0.251 0.239 rg -0.0105 Tc 0.514 0 Td (ce )Tj 0.012 Tc 1.189 0 Td (Tcoll )Tj 0.0118 Tc 2.567 0 Td (increased )Tj ET BT /Suspect <>BDC 0.722 0.725 0.71 rg /T1_0 1 Tf 0 Tc 10.1 0 0 10.1 462.4921 546.476 Tm (\267)Tj 0.149 0.153 0.141 rg 0.297 0 Td (l)Tj 0.251 0.251 0.239 rg -0.0066 Tc 0.236 0 Td (ess )Tj EMC ET BT 0.31 0.31 0.302 rg /T1_0 1 Tf 0.0453 Tc 10.1 0 0 10.1 483.8031 546.476 Tm (than )Tj 0.251 0.251 0.239 rg 0.0121 Tc 2.278 0 Td (Rcoll, )Tj 0.0328 Tc -20.005 -1.093 Td (the )Tj -0.035 Tc 10.5769 0 0 10.7 321.97 535.44 Tm (Cs )Tj 0.05 Tc 11.1292 0 0 10.1 336.85 535.44 Tm (of )Tj 0.009 Tc 10.1 0 0 10.1 350.38 535.44 Tm (the )Tj -0.0029 Tc 1.664 0 Td (wedged )Tj 0.0197 Tc 3.551 0 Td (segment )Tj 0.014 Tc 3.853 0 Td (decreased)Tj 0.149 0.153 0.141 rg 0 Tc 4.124 0 Td (. )Tj 0.251 0.251 0.239 rg 0.0123 Tc 0.621 0 Td (Since )Tj 0.0109 Tc 2.677 0 Td (this )Tj 0.0127 Tc -21.061 -1.092 Td (decrease )Tj 0.05 Tc 11.1292 0 0 10.1 342.61 524.41 Tm (of )Tj 0.0121 Tc 10.1 0 0 10.1 353.66 524.41 Tm (Cs )Tj 0.05 Tc 10.1212 0 0 10.1 367.1 524.41 Tm (cannot )Tj 0.0171 Tc 10.1 0 0 10.1 399.37 524.41 Tm (be )Tj 0.0161 Tc 1.129 0 Td (explained )Tj 0.0076 Tc 4.337 0 Td (by )Tj 0.0328 Tc 1.28 0 Td (the )Tj 0.0224 Tc 1.513 0 Td (direct )Tj -0.0037 Tc 2.613 0 Td (effect )Tj 0.05 Tc 11.1292 0 0 10.1 304.21 513.85 Tm (of )Tj 0.0211 Tc 10.1 0 0 10.1 315.82 513.85 Tm (methacholine )Tj 0.0058 Tc 5.894 0 Td (wit)Tj 0.149 0.153 0.141 rg 0 Tc 1.331 0 Td (h)Tj 0.251 0.251 0.239 rg -0.0005 Tc 0.516 0 Td (in )Tj 0.31 0.31 0.302 rg 0.0328 Tc 1.099 0 Td (the )Tj 0.0151 Tc 1.509 0 Td (segment, )Tj 0.251 0.251 0.239 rg 0.0324 Tc 3.998 0 Td (it )Tj 0.035 Tc 0.861 0 Td (must )Tj 0.0171 Tc 2.332 0 Td (be )Tj 0.0196 Tc 1.225 0 Td (due )Tj 0.05 Tc 10.4772 0 0 10.1 523.17 513.85 Tm (to )Tj -0.0125 Tc 10.1 0 0 10.1 304.21 502.81 Tm (effects )Tj 0.05 Tc 11.3843 0 0 10.1 336.36 502.81 Tm (at )Tj 0.0328 Tc 10.1 0 0 10.1 350.86 502.81 Tm (the )Tj 0.149 0.153 0.141 rg 0 Tc 1.847 0 Td (l)Tj 0.31 0.31 0.302 rg -0.0091 Tc 0.236 0 Td (evel )Tj 0.251 0.251 0.239 rg 0.05 Tc 11.1292 0 0 10.1 394.45 502.81 Tm (of )Tj 0.009 Tc 10.1 0 0 10.1 409.42 502.81 Tm (the )Tj 0.0186 Tc 1.845 0 Td (external )Tj 0.0226 Tc 3.942 0 Td (surface )Tj 0.05 Tc 11.6856 0 0 10.1 503.89 502.81 Tm (of )Tj 0.0328 Tc 10.1 0 0 10.1 518.86 502.81 Tm (the )Tj 0.376 0.376 0.369 rg -0.002 Tc -21.255 -1.094 Td (segme)Tj 0.251 0.251 0.239 rg 0 Tc 2.627 0 Td (n)Tj 0.376 0.376 0.369 rg -0.035 Tc 9.8029 0 0 10.1 335.98 491.76 Tm (t. )Tj 0.251 0.251 0.239 rg 0 Tc 10.1 0 0 10.1 348.45 491.76 Tm (W)Tj 0.376 0.376 0.369 rg 0.943 0 Td (e )Tj -0.0044 Tc 1.09 0 Td (suggest )Tj 0.251 0.251 0.239 rg 0.0246 Tc 3.766 0 Td (that )Tj -0.035 Tc 9.7344 0 0 10.1 431.02 491.76 Tm (th)Tj 0.376 0.376 0.369 rg 0 Tc 10.1 0 0 10.1 439.09 491.76 Tm (e )Tj 0.31 0.31 0.302 rg 0.0127 Tc 1.094 0 Td (decrease )Tj 0.376 0.376 0.369 rg 0.05 Tc 11.1292 0 0 10.1 492.37 491.76 Tm (of )Tj -0.035 Tc 10.0962 0 0 10.1 508.22 491.76 Tm (Cs )Tj 0.31 0.31 0.302 rg 9.3682 0 0 10.1 526 491.76 Tm (is )Tj 0.376 0.376 0.369 rg 0.0029 Tc 10.1 0 0 10.1 304.18 480.72 Tm (seco)Tj 0.251 0.251 0.239 rg 0.0013 Tc 1.819 0 Td (nd)Tj 0.376 0.376 0.369 rg 0.0329 Tc 1.084 0 Td (ary )Tj ET BT /Suspect <>BDC 0.31 0.31 0.302 rg /T1_1 1 Tf -0.035 Tc 6.07 0 0 7.4001 351.71 480.72 Tm (LO )Tj EMC ET BT /T1_0 1 Tf 0.0328 Tc 10.1 0 0 10.1 364.3 480.72 Tm (the )Tj 0.376 0.376 0.369 rg 0.0243 Tc 1.655 0 Td (const)Tj 0.251 0.251 0.239 rg -0.035 Tc 9.1875 0 0 10.1 404.15 480.72 Tm (ri)Tj 0.376 0.376 0.369 rg 0.05 Tc 10.8808 0 0 10.1 409.81 480.72 Tm (ct)Tj 0.251 0.251 0.239 rg 0 Tc 10.1 0 0 10.1 418.48 480.72 Tm (i)Tj 0.376 0.376 0.369 rg 0.0184 Tc 0.236 0 Td (on )Tj 0 Tc 1.473 0 Td (o)Tj 0.251 0.251 0.239 rg 0.569 0 Td (f )Tj 0.376 0.376 0.369 rg 0.769 0 Td (t)Tj 0.149 0.153 0.141 rg 0.286 0 Td (h)Tj 0.31 0.31 0.302 rg 0.513 0 Td (e )Tj 0.376 0.376 0.369 rg 0.05 Tc 10.3603 0 0 10.1 465.5 480.72 Tm (co)Tj 0.251 0.251 0.239 rg 0.0081 Tc 10.1 0 0 10.1 476.07 480.72 Tm (llat)Tj 0.376 0.376 0.369 rg 0.0182 Tc 1.329 0 Td (era)Tj 0.251 0.251 0.239 rg 0 Tc 1.333 0 Td (l )Tj ET BT /Suspect <>BDC 0.31 0.31 0.302 rg /T1_0 1 Tf 0.0474 Tc 10.1 0 0 10.1 509.3091 480.72 Tm (path\255)Tj EMC ET BT /T1_0 1 Tf -0.002 Tc 10.1 0 0 10.1 304.3195 470.1554 Tm (ways )Tj 0.0404 Tc 2.47 0 Td (that )Tj 0.376 0.376 0.369 rg 0.0275 Tc 1.988 0 Td (co)Tj 0.251 0.251 0.239 rg -0.0204 Tc 1.008 0 Td (uld )Tj 0.31 0.31 0.302 rg 0.0124 Tc 1.703 0 Td (induce )Tj 0.0185 Tc 3.087 0 Td (an )Tj 0.251 0.251 0.239 rg -0.035 Tc 9.2582 0 0 10.1 422.32 470.16 Tm (in)Tj 0.376 0.376 0.369 rg 0 Tc 10.1 0 0 10.1 429.98 470.16 Tm (c)Tj 0.251 0.251 0.239 rg -0.0153 Tc 0.484 0 Td (rea)Tj 0.376 0.376 0.369 rg 0.0012 Tc 1.27 0 Td (se )Tj 0.31 0.31 0.302 rg 0.05 Tc 11.1292 0 0 10.1 459.73 470.16 Tm (of )Tj 0.009 Tc 10.1 0 0 10.1 472.3 470.16 Tm (the )Tj 0.376 0.376 0.369 rg 0.0035 Tc 1.616 0 Td (vo)Tj 0.251 0.251 0.239 rg 0.0048 Tc 1.039 0 Td (lume )Tj 0.31 0.31 0.302 rg 0.05 Tc 11.1292 0 0 10.1 523.09 470.16 Tm (of )Tj 0.009 Tc 10.1 0 0 10.1 304.78 459.12 Tm (the )Tj -0.0029 Tc 1.474 0 Td (wedged )Tj 0.376 0.376 0.369 rg -0.002 Tc 3.361 0 Td (segme)Tj 0.251 0.251 0.239 rg -0.0133 Tc 2.627 0 Td (nt)Tj 0.471 0.471 0.459 rg 0 Tc 0.841 0 Td (, )Tj 0.376 0.376 0.369 rg 0.481 0 Td (a )Tj 0.31 0.31 0.302 rg 0.037 Tc 0.665 0 Td (change )Tj 0.251 0.251 0.239 rg -0.035 Tc 9.9195 0 0 10.1 432.88 459.12 Tm (in )Tj ET BT /Suspect <>BDC 0.31 0.31 0.302 rg /T1_0 1 Tf 0.0118 Tc 10.1 0 0 10.1 443.44 459.12 Tm (its )Tj EMC ET BT 0.376 0.376 0.369 rg /T1_0 1 Tf 0 Tc 10.1 0 0 10.1 455.3782 459.12 Tm (s)Tj 0.251 0.251 0.239 rg 0.298 0 Td (h)Tj 0.376 0.376 0.369 rg 0.0286 Tc 0.609 0 Td (ape, )Tj 0 Tc 1.996 0 Td (a )Tj -0.035 Tc 9.029 0 0 10.1 491.43 459.12 Tm (c.)Tj 0.251 0.251 0.239 rg 0.0223 Tc 10.1 0 0 10.1 496.31 459.12 Tm (hange )Tj -0.035 Tc 9.9195 0 0 10.1 524.08 459.12 Tm (in )Tj 0.31 0.31 0.302 rg 0.009 Tc 10.1 0 0 10.1 304.78 448.09 Tm (the )Tj 0.251 0.251 0.239 rg 0 Tc 1.569 0 Td (r)Tj 0.376 0.376 0.369 rg 0.0123 Tc 0.323 0 Td (egional )Tj 0 Tc 3.279 0 Td (e)Tj 0.251 0.251 0.239 rg 0.525 0 Td (l)Tj 0.376 0.376 0.369 rg -0.013 Tc 0.237 0 Td (as)Tj 0.251 0.251 0.239 rg -0.035 Tc 9.2906 0 0 10.1 373.9 448.09 Tm (ti)Tj 0.471 0.471 0.459 rg 0 Tc 10.1 0 0 10.1 379.1 448.09 Tm (c )Tj 0.31 0.31 0.302 rg -0.0078 Tc 0.769 0 Td (recoil)Tj 0.471 0.471 0.459 rg 0 Tc 2.314 0 Td (, )Tj 0.376 0.376 0.369 rg 0.481 0 Td (a)Tj 0.251 0.251 0.239 rg 0.579 0 Td (n )Tj 0.31 0.31 0.302 rg 0.0059 Tc 0.801 0 Td (increased )Tj 0.376 0.376 0.369 rg 0.0246 Tc 4.129 0 Td (st)Tj 0.251 0.251 0.239 rg -0.0321 Tc 0.766 0 Td (iffn)Tj 0.376 0.376 0.369 rg -0.0303 Tc 1.375 0 Td (ess )Tj 0.31 0.31 0.302 rg 0.05 Tc 11.1292 0 0 10.1 507.25 448.09 Tm (of )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.009 Tc 10.1 0 0 10.1 519.34 448.09 Tm (the )Tj EMC ET BT 0.376 0.376 0.369 rg /T1_0 1 Tf -0.0171 Tc 10.1 0 0 10.1 304.311 437.0507 Tm (wall )Tj 0.05 Tc 11.1292 0 0 10.1 329.65 437.05 Tm (of )Tj 0.31 0.31 0.302 rg 0.0328 Tc 10.1 0 0 10.1 346.54 437.05 Tm (the )Tj 0.376 0.376 0.369 rg 0.0099 Tc 1.984 0 Td (segme)Tj 0.251 0.251 0.239 rg -0.0133 Tc 2.627 0 Td (nt )Tj 0.376 0.376 0.369 rg 0 Tc 1.607 0 Td (a)Tj 0.251 0.251 0.239 rg -0.035 Tc 9.9824 0 0 10.1 414.71 437.05 Tm (nd )Tj 0.31 0.31 0.302 rg 0.03 Tc 10.1 0 0 10.1 433.42 437.05 Tm (more )Tj 0.0259 Tc 2.846 0 Td (interdependence )Tj 0.251 0.251 0.239 rg 0.0014 Tc -15.627 -1.094 Td (between )Tj 0 Tc 3.942 0 Td (t)Tj 0.149 0.153 0.141 rg 0.334 0 Td (h)Tj 0.31 0.31 0.302 rg 0.513 0 Td (e )Tj 0.251 0.251 0.239 rg -0.0124 Tc 1.008 0 Td (wedged )Tj 0.0118 Tc 3.647 0 Td (segment )Tj 0.0444 Tc 3.949 0 Td (and )Tj 0.31 0.31 0.302 rg 0.0328 Tc 2.147 0 Td (the )Tj 0.251 0.251 0.239 rg 0.0373 Tc 1.794 0 Td (surrounding )Tj 0.0107 Tc -17.342 -1.046 Td (lun)Tj 0.376 0.376 0.369 rg 0 Tc 1.331 0 Td (g )Tj 0.31 0.31 0.302 rg -0.035 Tc 9.82 0 0 10.1 326.16 415.44 Tm ([2, )Tj 0.251 0.251 0.239 rg 0 Tc 10.1 0 0 10.1 340.93 415.44 Tm (1)Tj 0.376 0.376 0.369 rg -0.0002 Tc 0.403 0 Td (3, )Tj 0.251 0.251 0.239 rg -0.035 Tc 8.5945 0 0 10.1 357.3 415.44 Tm (14)Tj 0.376 0.376 0.369 rg 9.3641 0 0 10.1 365.66 415.44 Tm (]. )Tj 0.251 0.251 0.239 rg 0 Tc 10.1 0 0 10.1 314.38 403.93 Tm (A)Tj 0.376 0.376 0.369 rg 0.701 0 Td (s )Tj 0.31 0.31 0.302 rg 0.0059 Tc 0.871 0 Td (predicted )Tj 0.0076 Tc 4.276 0 Td (by )Tj ET BT /Suspect <>BDC 0.251 0.251 0.239 rg /T1_0 1 Tf 0 Tc 10.1 0 0 10.1 388.2615 403.93 Tm (R)Tj 0.376 0.376 0.369 rg -0.035 Tc 8.998 0 0 10.1 395.52 403.93 Tm (ussELL. )Tj EMC ET BT /T1_0 1 Tf 0 Tc 10.1 0 0 10.1 427.44 403.93 Tm ([)Tj 0.251 0.251 0.239 rg 0.417 0 Td (1)Tj 0.376 0.376 0.369 rg -0.035 Tc 9.808 0 0 10.1 435.22 403.93 Tm (5], )Tj 0.251 0.251 0.239 rg 0 Tc 10.1 0 0 10.1 450.16 403.93 Tm (i)Tj 0.376 0.376 0.369 rg 0.0392 Tc 0.232 0 Td (so)Tj 0.251 0.251 0.239 rg 0.05 Tc 10.4349 0 0 10.1 462.26 403.93 Tm (pr)Tj 0.376 0.376 0.369 rg 0 Tc 10.1 0 0 10.1 471.26 403.93 Tm (o)Tj 0.251 0.251 0.239 rg 0.578 0 Td (t)Tj 0.376 0.376 0.369 rg 0.276 0 Td (e)Tj 0.251 0.251 0.239 rg 0.485 0 Td (r)Tj 0.376 0.376 0.369 rg 0.323 0 Td (e)Tj 0.251 0.251 0.239 rg 0.485 0 Td (n)Tj 0.376 0.376 0.369 rg 0.514 0 Td (o)Tj 0.251 0.251 0.239 rg 0.524 0 Td (l )Tj ET BT /Suspect <>BDC 0.376 0.376 0.369 rg /T1_0 1 Tf 0.0194 Tc 10.1 0 0 10.1 510.1349 403.93 Tm (com\255)Tj EMC ET BT 0.251 0.251 0.239 rg /T1_0 1 Tf -0.035 Tc 9.8228 0 0 10.1 304.34 392.89 Tm (pl)Tj 0.376 0.376 0.369 rg 0 Tc 10.1 0 0 10.1 311.89 392.89 Tm (e)Tj 0.251 0.251 0.239 rg 0.484 0 Td (t)Tj 0.376 0.376 0.369 rg -0.0061 Tc 0.276 0 Td (ely )Tj 0.251 0.251 0.239 rg -0.0126 Tc 1.619 0 Td (inh)Tj 0.376 0.376 0.369 rg -0.0005 Tc 1.331 0 Td (ib)Tj 0.251 0.251 0.239 rg -0.0151 Tc 0.808 0 Td (it)Tj 0.376 0.376 0.369 rg 0 Tc 0.612 0 Td (s )Tj ET BT /Suspect <>BDC 0.31 0.31 0.302 rg /T1_0 1 Tf 0.009 Tc 10.1 0 0 10.1 371.5002 392.89 Tm (the )Tj EMC ET BT 0.376 0.376 0.369 rg /T1_0 1 Tf -0.0304 Tc 10.1 0 0 10.1 387.7309 392.89 Tm (effec)Tj 0.251 0.251 0.239 rg 0 Tc 1.957 0 Td (t)Tj 0.471 0.471 0.459 rg 0.273 0 Td (s )Tj 0.376 0.376 0.369 rg 0.05 Tc 11.1292 0 0 10.1 417.49 392.89 Tm (of )Tj 0.251 0.251 0.239 rg 0.017 Tc 10.1 0 0 10.1 430.06 392.89 Tm (meth)Tj 0.376 0.376 0.369 rg 0.028 Tc 2.131 0 Td (ac)Tj 0.251 0.251 0.239 rg 0.0019 Tc 0.959 0 Td (ho)Tj 0.149 0.153 0.141 rg 0 Tc 1.085 0 Td (l)Tj 0.376 0.376 0.369 rg 0.286 0 Td (i)Tj 0.251 0.251 0.239 rg -0.035 Tc 10.0807 0 0 10.1 477.59 392.89 Tm (ne)Tj 0.376 0.376 0.369 rg 0 Tc 10.1 0 0 10.1 487.47 392.89 Tm (. )Tj 0.251 0.251 0.239 rg 0.05 Tc 10.4334 0 0 10.1 493.42 392.89 Tm (Atr)Tj 0.376 0.376 0.369 rg 0 Tc 10.1 0 0 10.1 508.22 392.89 Tm (o)Tj 0.251 0.251 0.239 rg 0.582 0 Td (p)Tj 0.376 0.376 0.369 rg 0.513 0 Td (i)Tj 0.251 0.251 0.239 rg 0.292 0 Td (n)Tj 0.376 0.376 0.369 rg 0.465 0 Td (e )Tj -0.035 Tc 9.3682 0 0 10.1 304.24 382.33 Tm (is )Tj 0.0218 Tc 10.1 0 0 10.1 313.34 382.33 Tm (also )Tj -0.035 Tc 9.5735 0 0 10.1 333.58 382.33 Tm (ve)Tj 0.251 0.251 0.239 rg 0 Tc 10.1 0 0 10.1 343.19 382.33 Tm (r)Tj 0.376 0.376 0.369 rg (y )Tj 0.028 Tc 1.084 0 Td (ac)Tj 0.251 0.251 0.239 rg 0 Tc 0.958 0 Td (t)Tj 0.376 0.376 0.369 rg -0.0316 Tc 0.327 0 Td (ive )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 10.1194 0 0 10.1 381.98 382.33 Tm (at )Tj EMC /Suspect <>BDC 0.009 Tc 10.1 0 0 10.1 393.58 382.33 Tm (the )Tj EMC ET BT 0.251 0.251 0.239 rg /T1_0 1 Tf 0 Tc 10.1 0 0 10.1 409.3461 382.33 Tm (l)Tj 0.376 0.376 0.369 rg -0.0091 Tc 0.188 0 Td (evel )Tj 0 Tc 1.95 0 Td (o)Tj 0.251 0.251 0.239 rg 0.569 0 Td (f )Tj 0.376 0.376 0.369 rg 0.0275 Tc 0.571 0 Td (co)Tj 0.251 0.251 0.239 rg 0 Tc 1.054 0 Td (n)Tj 0.376 0.376 0.369 rg -0.0229 Tc 0.51 0 Td (st)Tj 0.251 0.251 0.239 rg -0.035 Tc 9.1875 0 0 10.1 466.07 382.33 Tm (ri)Tj 0.376 0.376 0.369 rg 0.0068 Tc 10.1 0 0 10.1 471.74 382.33 Tm (cted )Tj 0.0275 Tc 1.996 0 Td (co)Tj 0.251 0.251 0.239 rg -0.035 Tc 8.5757 0 0 10.1 502.49 382.33 Tm (ll)Tj 0.376 0.376 0.369 rg 0 Tc 10.1 0 0 10.1 507.74 382.33 Tm (a)Tj 0.251 0.251 0.239 rg -0.0031 Tc 0.531 0 Td (teral )Tj 0 Tc -20.669 -1.094 Td (p)Tj 0.376 0.376 0.369 rg 0.511 0 Td (a)Tj 0.251 0.251 0.239 rg 0.003 Tc 0.531 0 Td (thwa)Tj 0.376 0.376 0.369 rg -0.0213 Tc 2.045 0 Td (ys. )Tj 0.251 0.251 0.239 rg 0.05 Tc 10.4937 0 0 10.1 353.19 371.28 Tm (Th)Tj 0.376 0.376 0.369 rg 0 Tc 10.1 0 0 10.1 365.17 371.28 Tm (e )Tj 0.31 0.31 0.302 rg 0.0044 Tc 1.142 0 Td (ability )Tj 0.376 0.376 0.369 rg 0.05 Tc 11.1292 0 0 10.1 409.81 371.28 Tm (of )Tj 0.31 0.31 0.302 rg 0.0364 Tc 10.1 0 0 10.1 425.18 371.28 Tm (atropine )Tj 0.376 0.376 0.369 rg -0.0143 Tc 4.238 0 Td (to )Tj 0.31 0.31 0.302 rg 0.0026 Tc 1.474 0 Td (reverse )Tj 0.0328 Tc 3.563 0 Td (the )Tj 0.376 0.376 0.369 rg 0.0138 Tc -21.299 -1.092 Td (cons)Tj 0.251 0.251 0.239 rg -0.0146 Tc 1.956 0 Td (tri)Tj 0.376 0.376 0.369 rg -0.0047 Tc 0.943 0 Td (ctive )Tj -0.0227 Tc 2.233 0 Td (effect )Tj 0 Tc 2.472 0 Td (o)Tj 0.251 0.251 0.239 rg 0.627 0 Td (n )Tj 0.149 0.153 0.141 rg 0.851 0 Td (R)Tj 0.376 0.376 0.369 rg 0.0275 Tc 0.66 0 Td (co)Tj 0.251 0.251 0.239 rg -0.035 Tc 8.5757 0 0 10.1 412.73 360.25 Tm (ll )Tj 0 Tc 10.1 0 0 10.1 420.95 360.25 Tm (h)Tj 0.376 0.376 0.369 rg 0.05 Tc 10.2654 0 0 10.1 425.66 360.25 Tm (ad )Tj 0.31 0.31 0.302 rg 0.024 Tc 10.1 0 0 10.1 439.69 360.25 Tm (been )Tj 0.0038 Tc 2.223 0 Td (described )Tj 0.376 0.376 0.369 rg 0.0238 Tc 4.241 0 Td (before )Tj 0.251 0.251 0.239 rg -0.0305 Tc -19.938 -1.093 Td ([16], )Tj 0.0444 Tc 2.39 0 Td (and )Tj 0.0324 Tc 2.141 0 Td (it )Tj -0.032 Tc 1.141 0 Td (is )Tj 0.31 0.31 0.302 rg 0 Tc 1.234 0 Td (a )Tj 0.251 0.251 0.239 rg 1.093 0 Td (d)Tj 0.149 0.153 0.141 rg 0.525 0 Td (i)Tj 0.251 0.251 0.239 rg 0.0084 Tc 0.292 0 Td (rect )Tj 0.0268 Tc 2.132 0 Td (inhibito)Tj 0.149 0.153 0.141 rg 0 Tc 3.334 0 Td (r )Tj 0.251 0.251 0.239 rg 0.05 Tc 11.1292 0 0 10.1 457.33 349.21 Tm (of )Tj 0.0144 Tc 10.1 0 0 10.1 472.3 349.21 Tm (methacholine. )Tj 0.0282 Tc -16.681 -1.094 Td (Various )Tj 0.0305 Tc 3.897 0 Td (methods )Tj 0.05 Tc 11.1292 0 0 10.1 385.33 338.16 Tm (of )Tj 0.0323 Tc 10.1 0 0 10.1 399.74 338.16 Tm (administration )Tj 0.004 Tc 6.805 0 Td (were )Tj 0 Tc 2.567 0 Td (u)Tj 0.376 0.376 0.369 rg 0.509 0 Td (s)Tj 0.251 0.251 0.239 rg 0.0272 Tc 0.336 0 Td (ed )Tj 0.0252 Tc 1.568 0 Td (for )Tj 0.0364 Tc -21.29 -1.093 Td (atropine )Tj 0.31 0.31 0.302 rg 0.0444 Tc 3.802 0 Td (and )Tj 0.251 0.251 0.239 rg 0.0326 Tc 1.909 0 Td (methac)Tj 0.149 0.153 0.141 rg 0 Tc 3.043 0 Td (h)Tj 0.251 0.251 0.239 rg 0.0109 Tc 0.514 0 Td (oline, )Tj 0.0444 Tc 2.614 0 Td (and )Tj 0 Tc 1.903 0 Td (i)Tj 0.149 0.153 0.141 rg 0.292 0 Td (n)Tj 0.251 0.251 0.239 rg 0.522 0 Td (t)Tj 0.149 0.153 0.141 rg 0.334 0 Td (r)Tj 0.251 0.251 0.239 rg 0.0333 Tc 0.371 0 Td (avenou)Tj 0.376 0.376 0.369 rg 0 Tc 3.038 0 Td (s )Tj 0.251 0.251 0.239 rg 0.0364 Tc 0.669 0 Td (atropine )Tj 0.0232 Tc -19.014 -1.092 Td (shoul)Tj 0.149 0.153 0.141 rg 0 Tc 2.238 0 Td (d )Tj 0.251 0.251 0.239 rg 0.0221 Tc 1.292 0 Td (have )Tj 0.05 Tc 10.2654 0 0 10.1 366.14 316.09 Tm (an )Tj 0.0382 Tc 10.1 0 0 10.1 383.9 316.09 Tm (addit)Tj 0 g 0 Tc 2.188 0 Td (i)Tj 0.251 0.251 0.239 rg 0.0354 Tc 0.283 0 Td (onal )Tj -0.0037 Tc 2.518 0 Td (effect )Tj -0.035 Tc 9.9195 0 0 10.1 464.56 316.09 Tm (in )Tj 0 Tc 10.1 0 0 10.1 479.98 316.09 Tm (t)Tj 0.149 0.153 0.141 rg 0.286 0 Td (h)Tj 0.251 0.251 0.239 rg 0.513 0 Td (e )Tj -0.0029 Tc 1.15 0 Td (wedged )Tj 0.0118 Tc -19.403 -1.093 Td (segment )Tj 0.0404 Tc 4.051 0 Td (that )Tj 0.012 Tc 2.273 0 Td (aerosolized )Tj 0.006 Tc 5.331 0 Td (mecholyl )Tj 0.0076 Tc 4.364 0 Td (did )Tj 0.0285 Tc 2.005 0 Td (not )Tj 0.018 Tc 1.996 0 Td (reach)Tj 0.376 0.376 0.369 rg 0 Tc 2.309 0 Td (. )Tj 0.251 0.251 0.239 rg 0.0126 Tc -22.359 -1.046 Td (Nevertheless, )Tj 0 Tc 5.875 0 Td (s)Tj 0.149 0.153 0.141 rg 0.434 0 Td (i)Tj 0.251 0.251 0.239 rg -0.0022 Tc 0.292 0 Td (nce )Tj 0.05 Tc 10.7518 0 0 10.1 386.77 294.49 Tm (at)Tj 0.149 0.153 0.141 rg 0 Tc 10.1 0 0 10.1 395.51 294.49 Tm (r)Tj 0.251 0.251 0.239 rg 0.0138 Tc 0.371 0 Td (opine, )Tj 0.0345 Tc 2.899 0 Td (as )Tj -0.02 Tc 1.15 0 Td (we)Tj 0.149 0.153 0.141 rg -0.035 Tc 8.5757 0 0 10.1 452.09 294.49 Tm (ll )Tj 0.251 0.251 0.239 rg 0.0345 Tc 10.1 0 0 10.1 460.22 294.49 Tm (as )Tj 0.0279 Tc 1.19 0 Td (isoprotere)Tj 0.149 0.153 0.141 rg 0 Tc 4.237 0 Td (n)Tj 0.251 0.251 0.239 rg -0.0043 Tc 0.561 0 Td (ol, )Tj 0.004 Tc -21.52 -1.094 Td (were )Tj 0.0196 Tc 2.605 0 Td (able )Tj 0.31 0.31 0.302 rg 0.0333 Tc 2.384 0 Td (to )Tj 0.251 0.251 0.239 rg 0.0158 Tc 1.467 0 Td (immediately )Tj 0.0105 Tc 5.805 0 Td (reverse )Tj 0.009 Tc 3.611 0 Td (the )Tj 0.019 Tc 1.846 0 Td (constrictive )Tj 0.0275 Tc -17.727 -1.092 Td (action )Tj 0.05 Tc 11.1292 0 0 10.1 333.01 272.41 Tm (of )Tj 0.006 Tc 10.1 0 0 10.1 345.58 272.41 Tm (mecholyl )Tj 0 Tc 4.127 0 Td (o)Tj 0.149 0.153 0.141 rg 0.532 0 Td (n )Tj 0.251 0.251 0.239 rg 0.0283 Tc 0.899 0 Td (Rco)Tj 0.149 0.153 0.141 rg -0.035 Tc 9.5285 0 0 10.1 418.96 272.41 Tm (ll )Tj 0.251 0.251 0.239 rg 0.05 Tc 10.3398 0 0 10.1 427.57 272.41 Tm (and )Tj 0.0236 Tc 10.1 0 0 10.1 446.78 272.41 Tm (Cs, )Tj 0.0109 Tc 1.719 0 Td (this )Tj 0.019 Tc 1.798 0 Td (constrictive )Tj 0.0275 Tc -17.727 -1.093 Td (action )Tj 0.0192 Tc 3.145 0 Td (must )Tj -0.0304 Tc 2.569 0 Td (be )Tj 0.037 Tc 1.415 0 Td (attribute)Tj 0.149 0.153 0.141 rg 0 Tc 3.612 0 Td (d )Tj 0.251 0.251 0.239 rg 0.05 Tc 10.4772 0 0 10.1 422.37 261.37 Tm (to )Tj 0 Tc 10.1 0 0 10.1 436.22 261.37 Tm (a )Tj 0.0224 Tc 0.95 0 Td (direct )Tj -0.0037 Tc 2.85 0 Td (effect )Tj 0.31 0.31 0.302 rg 0.0184 Tc 2.757 0 Td (on )Tj 0.009 Tc 1.576 0 Td (the )Tj 0.251 0.251 0.239 rg 0.0438 Tc -21.303 -1.093 Td (smooth )Tj 0.0149 Tc 3.434 0 Td (muscle )Tj 0.0333 Tc 3.184 0 Td (to)Tj 0.149 0.153 0.141 rg 0 Tc 0.856 0 Td (n)Tj 0.251 0.251 0.239 rg -0.0079 Tc 0.513 0 Td (e, )Tj 0.0444 Tc 0.951 0 Td (and )Tj 0.05 Tc 10.4827 0 0 10.1 412.31 250.33 Tm (not )Tj 0.0333 Tc 10.1 0 0 10.1 429.58 250.33 Tm (to )Tj 0.05 Tc 10.1211 0 0 10.1 441.02 250.33 Tm (othe)Tj 0.149 0.153 0.141 rg 0 Tc 10.1 0 0 10.1 459.83 250.33 Tm (r )Tj 0.251 0.251 0.239 rg 0.0142 Tc 0.664 0 Td (more )Tj 0.0192 Tc 2.38 0 Td (persistent )Tj 0 Tc -18.535 -1.047 Td (p)Tj 0.149 0.153 0.141 rg 0.567 0 Td (h)Tj 0.251 0.251 0.239 rg 0.0283 Tc 0.513 0 Td (enome)Tj 0.149 0.153 0.141 rg 0 Tc 2.814 0 Td (n)Tj 0.31 0.31 0.302 rg 0.514 0 Td (a )Tj 0.251 0.251 0.239 rg -0.0187 Tc 0.856 0 Td (like )Tj 0.0083 Tc 1.813 0 Td (mucosal )Tj 0.0292 Tc 3.747 0 Td (oedema )Tj 0.05 Tc 10.5727 0 0 10.1 448.7 239.76 Tm (or )Tj 0.0142 Tc 10.1 0 0 10.1 461.26 239.76 Tm (mucus )Tj 0.0009 Tc 3.046 0 Td (plugging. )Tj 0 Tc 9.4 0 0 9.4 394.46 212.41 Tm (C)Tj 0.149 0.153 0.141 rg 0.05 Tc 9.7902 0 0 9.4 401.19 212.41 Tm (on)Tj 0.251 0.251 0.239 rg 0 Tc 9.4 0 0 9.4 411.27 212.41 Tm (c)Tj 0.149 0.153 0.141 rg 0.0042 Tc 0.512 0 Td (lu)Tj 0.251 0.251 0.239 rg 0 Tc 0.761 0 Td (s)Tj 0.149 0.153 0.141 rg 0.0079 Tc 0.465 0 Td (ion )Tj 0.251 0.251 0.239 rg 0.0112 Tc 10.1 0 0 10.1 313.39 195.61 Tm (Mecholyl )Tj 0.0168 Tc 4.7 0 Td (aerosolized )Tj 0.31 0.31 0.302 rg 0.0471 Tc 5.467 0 Td (in )Tj 0.251 0.251 0.239 rg 0.0328 Tc 1.574 0 Td (the )Tj 0.31 0.31 0.302 rg 0.0373 Tc 2.032 0 Td (surrounding )Tj 0.251 0.251 0.239 rg 0.0147 Tc 5.946 0 Td (lung )Tj 0.31 0.31 0.302 rg 0.0118 Tc -20.72 -1.046 Td (increased )Tj 0.251 0.251 0.239 rg 0 Tc 4.758 0 Td (t)Tj 0.149 0.153 0.141 rg 0.286 0 Td (h)Tj 0.251 0.251 0.239 rg 0.513 0 Td (e )Tj 0.0227 Tc 1.237 0 Td (collateral )Tj 0.0114 Tc 4.761 0 Td (resistance )Tj 0.05 Tc 11.1292 0 0 10.1 469.33 185.05 Tm (of )Tj 0 Tc 10.1 0 0 10.1 486.14 185.05 Tm (a )Tj 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10.1 302.7881 97.2006 Tm (gic )Tj 0.251 0.251 0.239 rg 0.0236 Tc 1.529 0 Td (receptors )Tj 0.0157 Tc 4.173 0 Td (described )Tj -0.0005 Tc 4.327 0 Td (in )Tj 0.0188 Tc 1.15 0 Td (previous )Tj 0.017 Tc 3.929 0 Td (studies )Tj -0.035 Tc 9.0118 0 0 10 487.94 97.2 Tm ([S\). )Tj ET endstream endobj 43 0 obj <>stream Hd͊zy8 >sRhF^#y QG#Oç==o/ϧ;c_mӷKv|~_oo~y>}~W=|z>{O݇q~?>Ï?o+~ߒ~;%zΏx߽w;>lp?(O?{wٸ^ PZUuTGu^5P5FjFDMԤU PjVjUmFmک]uPuNNE]E5|| _#_k55|| _#_k55|| _#_k55|| _#_k5Z||-_+_kZ||-_+_kZ||-_+_kZ||-_+_ku:||_'_uu:||_'_uu:||_'_uu:||_'_uz||=_/_z||=_/_z||=_/_z||=_/_ || ߀o77 || ߀o77 || ߀o77 || ߀o77 KG#(~? ?G#(~? ?G#(~? ?G#(~? ?z $߄o77MM&|| $߄o77MM&|| $߄o77MM&|| $߄o77MM&||3,ߌo77f||3,ߌo77f||3,ߌo77f||3,ߌo77f|| "߂oȷ[--|| "߂oȷ[--|| "߂oȷ[--|| "߂oȷ[--||+*ߊoŷʷ[V||+*ߊoŷʷ[V||+*ߊoŷʷ[V||+*ߊoŷʷ[V|| &߆o÷ɷmm6|| &߆o÷ɷmm6|| &߆o÷ɷmm6|| &߆o÷ɷmm6|ۯ\t;]~~߅ww;]~~߅ww;]~~߅ww;]~~߅w߁w;;|C߁w;;|C߁w;;|C߁w;;|C߉w;;NN|'S߉w;;NN|'S߉w;;NN|'S߉w;;NN|'S ߅w]..|K ߅w]..|K ߅w]..|K ߅w]..|?|x>/Filter/JBIG2Decode/Height 1752/ImageMask 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0 8.1 142.2 630.97 Tm (Appl )Tj 0.0055 Tc 2.481 0 Td (Physiol: )Tj -0.0006 Tc 4.03 0 Td (Respirat )Tj -0.0152 Tc 3.97 0 Td (Environ )Tj -0.0018 Tc 3.793 0 Td (Exercise )Tj ET BT /Suspect <>BDC /T1_3 1 Tf 0.0125 Tc 8.1 0 0 8.1 59.58 621.8494 Tm (Physial)Tj 0.447 0.451 0.439 rg 0 Tc 3.019 0 Td (, )Tj EMC /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf -0.0346 Tc 8 0 0 8 89.48 621.85 Tm (1979, )Tj EMC ET BT /T1_0 1 Tf -0.0174 Tc 8 0 0 8 108.928 621.85 Tm (46, )Tj -0.0175 Tc 1.612 0 Td (966)Tj 0.51 0.514 0.498 rg 0 Tc 1.56 0 Td (-)Tj 0.365 0.365 0.357 rg -0.015 Tc 0.54 0 Td (972. )Tj -0.0054 Tc -9.961 -1.14 Td (6. )Tj 0.306 0.306 0.298 rg 0.0097 Tc 1.749 0 Td (Milic-Emili )Tj 0.0291 Tc 5.219 0 Td (J, )Tj 0.0452 Tc 1.081 0 Td (Mead )Tj 0 Tc 2.759 0 Td (J)Tj 0.51 0.514 0.498 rg 0.47 0 Td (, )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.1286 0 0 8 154.01 612.73 Tm (Turner )Tj 0.306 0.306 0.298 rg 8.3646 0 0 8 180.43 612.73 Tm (JM)Tj 0.447 0.451 0.439 rg 0 Tc 8 0 0 8 192.36 612.73 Tm (, )Tj 0.306 0.306 0.298 rg 0.0347 Tc 0.605 0 Td (Glauser )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.104 0 0 8 226.52 612.73 Tm (EM. )Tj 0.51 0.514 0.498 rg 0 Tc 8 0 0 8 245.19 612.73 Tm (-)Tj 0.306 0.306 0.298 rg 0.0298 Tc 0.905 0 Td (Improved )Tj 0.0174 Tc -24.116 -1.08 Td (technique )Tj 0.365 0.365 0.357 rg 0.0374 Tc 4.551 0 Td (for )Tj 0.306 0.306 0.298 rg 0.0266 Tc 1.801 0 Td (estimating )Tj 0.365 0.365 0.357 rg 0 Tc 4.931 0 Td (p)Tj 0.208 0.208 0.2 rg 0.53 0 Td (l)Tj 0.306 0.306 0.298 rg 0.0309 Tc 0.239 0 Td (eural )Tj 0.0227 Tc 2.711 0 Td (pressure )Tj 0.0259 Tc 4.067 0 Td (from )Tj 0.0223 Tc 2.581 0 Td (esophagea)Tj 0.208 0.208 0.2 rg 0 Tc 4.381 0 Td (l )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0055 Tc 8 0 0 8 272.638 604.09 Tm (bal\255)Tj EMC ET BT /T1_0 1 Tf 0.0238 Tc 8 0 0 8 58.958 594.97 Tm (loons. )Tj /T1_2 1 Tf 0 Tc 7.7 0 0 7.7 82.01 594.97 Tm (J )Tj /T1_3 1 Tf 0.0442 Tc 8.1 0 0 8.1 88.92 594.97 Tm (Appf )Tj ET BT /Suspect <>BDC /T1_3 1 Tf -0.008 Tc 8.1 0 0 8.1 107.5824 594.97 Tm (Physiol, )Tj EMC ET BT /T1_0 1 Tf -0.0346 Tc 8 0 0 8 137.48 594.97 Tm (1964, )Tj 0.365 0.365 0.357 rg -0.035 Tc 7.7937 0 0 8 158.13 594.97 Tm (19, )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0308 Tc 8 0 0 8 169.87 594.97 Tm (207-211. )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 7.6478 0 0 8 58.96 586.33 Tm (7. )Tj 0.365 0.365 0.357 rg 0.0119 Tc 8 0 0 8 73.4 586.33 Tm (Lulling )Tj 0.306 0.306 0.298 rg 0.0291 Tc 3.3 0 Td (J, )Tj ET BT /Suspect <>BDC 0.208 0.208 0.2 rg /T1_0 1 Tf 0 Tc 8 0 0 8 108.448 586.33 Tm (P)Tj 0.306 0.306 0.298 rg 0.0267 Tc 0.602 0 Td (rignol )Tj EMC ET BT /T1_0 1 Tf 0 Tc 8 0 0 8 135.792 586.33 Tm (J)Tj 0.447 0.451 0.439 rg 0.47 0 Td (, )Tj 0.306 0.306 0.298 rg 0.005 Tc 0.61 0 Td (Lievens )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0107 Tc 8 0 0 8 172.76 586.33 Tm (P. )Tj EMC ET BT 0.365 0.365 0.357 rg /T1_0 1 Tf 0 Tc 8 0 0 8 182.296 586.33 Tm (-)Tj 0.306 0.306 0.298 rg 0.0217 Tc 0.966 0 Td (Exper)Tj 0.208 0.208 0.2 rg 0 Tc 2.456 0 Td (i)Tj 0.365 0.365 0.357 rg 0.0215 Tc 0.308 0 Td (mental )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0307 Tc 8 0 0 8 238.08 586.33 Tm (bronchopneu\255)Tj EMC ET BT /T1_0 1 Tf 0.0379 Tc 8 0 0 8 59.024 577.21 Tm (mopathy )Tj 0.033 Tc 4.012 0 Td (due )Tj 0.05 Tc 8.1489 0 0 8 105.58 577.21 Tm (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 9.4078 0 0 8 114.55 577.21 Tm (S0)Tj 0 Tc 5.2 0 0 5.2 125.25 575.29 Tm (2 )Tj EMC ET BT 0.208 0.208 0.2 rg /T1_0 1 Tf 8 0 0 8 130.97 577.21 Tm (i)Tj 0.306 0.306 0.298 rg 0.247 0 Td (n )Tj 0.05 Tc 8.0143 0 0 8 139.18 577.21 Tm (the )Tj 0.365 0.365 0.357 rg 0.0197 Tc 8 0 0 8 151.61 577.21 Tm (dog. )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_3 1 Tf -0.0136 Tc 8.1 0 0 8.1 169.56 577.21 Tm (Arch )Tj EMC ET BT /T1_3 1 Tf 0.017 Tc 8.1 0 0 8.1 187.7364 577.21 Tm (Exp )Tj ET BT /Suspect <>BDC /T1_3 1 Tf 0.0222 Tc 8.1 0 0 8.1 203.094 577.21 Tm (Pathol )Tj EMC /Suspect <>BDC -0.0088 Tc 3.022 0 Td (Pharmacof, )Tj EMC /Suspect <>BDC 0.365 0.365 0.357 rg /T1_0 1 Tf -0.0196 Tc 8 0 0 8 268.04 577.21 Tm (1968, )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf 0.003 Tc 8 0 0 8 58.512 568.562 Tm (261, )Tj 0.365 0.365 0.357 rg 0 Tc 2.191 0 Td (1)Tj 0.577 0.577 0.565 rg 0.384 0 Td (-)Tj 0.365 0.365 0.357 rg -0.0155 Tc 0.605 0 Td (25. )Tj 0.306 0.306 0.298 rg 0.0051 Tc -3.191 -1.14 Td (8. )Tj 0.0426 Tc 1.809 0 Td (loners )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.3836 0 0 8 95.91 559.44 Tm (CR, )Tj 0.306 0.306 0.298 rg 0.0494 Tc 8 0 0 8 111.77 559.44 Tm (Terry )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0083 Tc 8 0 0 8 133.41 559.44 Tm (PB, )Tj EMC ET BT /T1_0 1 Tf 0.0456 Tc 8 0 0 8 147.29 559.44 Tm (Traystman )Tj 0.0386 Tc 4.984 0 Td (RJ, )Tj 0.0173 Tc 1.741 0 Td (Menkes )Tj 0.0286 Tc 3.599 0 Td (HA.)Tj 0.51 0.514 0.498 rg 0 Tc 2.094 0 Td (-)Tj 0.306 0.306 0.298 rg 0.0008 Tc 0.846 0 Td (Effects )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.9033 0 0 8 278.32 559.44 Tm (of )Tj 0.306 0.306 0.298 rg 0.0327 Tc 8 0 0 8 58.49 550.33 Tm (lung )Tj 0.365 0.365 0.357 rg 0.0137 Tc 2.288 0 Td (volume )Tj 0.05 Tc 8.3916 0 0 8 104.56 550.33 Tm (on )Tj 0.0297 Tc 8 0 0 8 116.08 550.33 Tm (collateral )Tj 0.05 Tc 8.1466 0 0 8 151.12 550.33 Tm (and )Tj 0.024 Tc 8 0 0 8 166.96 550.33 Tm (airways )Tj 0.306 0.306 0.298 rg 0.0159 Tc 3.669 0 Td (resistance )Tj 0.365 0.365 0.357 rg 0.0191 Tc 4.492 0 Td (in )Tj 0.306 0.306 0.298 rg 0.0448 Tc 1.207 0 Td (mao. )Tj /T1_2 1 Tf 0 Tc 7.7 0 0 7.7 262.01 550.33 Tm (J )Tj 0.365 0.365 0.357 rg /T1_3 1 Tf 0.0442 Tc 8.1 0 0 8.1 269.4 550.33 Tm (Appf )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_3 1 Tf 0.0125 Tc 8.1 0 0 8.1 58.6218 541.6792 Tm (Physiof)Tj 0.51 0.514 0.498 rg 0 Tc 3.057 0 Td (: )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_3 1 Tf -0.0006 Tc 8.1 0 0 8.1 88.8672 541.6792 Tm (Respirat )Tj -0.0053 Tc 3.733 0 Td (Environ )Tj 0.365 0.365 0.357 rg 0.0066 Tc 3.556 0 Td (Exercise )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_3 1 Tf 0.0004 Tc 8.1 0 0 8.1 179.1093 541.6792 Tm (Physiol, )Tj EMC /Suspect <>BDC /T1_0 1 Tf -0.0196 Tc 8 0 0 8 209 541.68 Tm (1979, )Tj EMC ET BT /T1_0 1 Tf -0.0174 Tc 8 0 0 8 228.928 541.68 Tm (46, )Tj 0.0446 Tc 1.551 0 Td (67)Tj 0.447 0.451 0.439 rg 0 Tc 1.021 0 Td (-)Tj 0.306 0.306 0.298 rg -0.035 Tc 7.6564 0 0 8 254.32 541.68 Tm (73)Tj 0.447 0.451 0.439 rg 0 Tc 8 0 0 8 262.4 541.68 Tm (. )Tj 0.306 0.306 0.298 rg -0.035 Tc 7.6511 0 0 8 58.47 532.56 Tm (9. )Tj 0.023 Tc 8 0 0 8 72.93 532.56 Tm (Woolcock )Tj 0.0424 Tc 4.562 0 Td (AJ, )Tj 0.0331 Tc 1.798 0 Td (Macklem )Tj 0.0497 Tc 4.26 0 Td (PT. )Tj 0.365 0.365 0.357 rg 0 Tc 1.852 0 Td (-)Tj 0.306 0.306 0.298 rg 0.0236 Tc 0.967 0 Td (Mechanical )Tj 0.0238 Tc 5.213 0 Td (factors )Tj 0.0086 Tc 3.243 0 Td (influencing )Tj 0.0297 Tc -23.761 -1.14 Td (collateral )Tj 0.0235 Tc 4.269 0 Td (ventilation )Tj 0.0191 Tc 4.852 0 Td (in )Tj 0.0308 Tc 1.147 0 Td (human, )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.4476 0 0 8 167.44 523.44 Tm (dog )Tj 0.306 0.306 0.298 rg 0.034 Tc 8 0 0 8 183.28 523.44 Tm (and )Tj 0.026 Tc 1.871 0 Td (pig )Tj -0.0002 Tc 1.67 0 Td (lungs. )Tj /T1_2 1 Tf 0 Tc 7.4001 0 0 7.4001 233.69 523.44 Tm (J )Tj /T1_3 1 Tf 0.05 Tc 8.1631 0 0 8.1 240.12 523.44 Tm (App)Tj 0.208 0.208 0.2 rg 0 Tc 8.1 0 0 8.1 253.83 523.44 Tm (l )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_3 1 Tf 0.0027 Tc 8.1 0 0 8.1 258.7791 523.44 Tm (Physiol)Tj 0.447 0.451 0.439 rg 0 Tc (, )Tj EMC /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf -0.0346 Tc 8 0 0 8 59.24 514.8 Tm (1971, )Tj EMC /Suspect <>BDC 0.365 0.365 0.357 rg -0.0065 Tc 2.484 0 Td (30, )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0303 Tc 8 0 0 8 91.592 514.8 Tm (99-115. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.7937 0 0 8 58.77 505.69 Tm (10. )Tj EMC ET BT /T1_0 1 Tf 0.0354 Tc 8 0 0 8 76.77 505.69 Tm (Kaplan )Tj 0 Tc 3.539 0 Td (J)Tj 0.447 0.451 0.439 rg 0.41 0 Td (, )Tj 0.306 0.306 0.298 rg 0.024 Tc 0.731 0 Td (Koehler )Tj 0.05 Tc 8.0015 0 0 8 144.92 505.69 Tm (RC, )Tj 0.0344 Tc 8 0 0 8 161.69 505.69 Tm (Terry )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0217 Tc 8 0 0 8 184.29 505.69 Tm (PB, )Tj EMC ET BT /T1_0 1 Tf 0.0293 Tc 8 0 0 8 200.13 505.69 Tm (Menkes )Tj 0.0286 Tc 3.779 0 Td (HA, )Tj 0.0456 Tc 2.156 0 Td (Traystman )Tj 0.0086 Tc -23.636 -1.141 Td (RJ. )Tj 0.365 0.365 0.357 rg 0 Tc 2.034 0 Td (-)Tj 0.306 0.306 0.298 rg -0.0052 Tc 1.206 0 Td (Effect )Tj 0.05 Tc 8.9033 0 0 8 109.36 496.56 Tm (of )Tj 0.0127 Tc 8 0 0 8 121.37 496.56 Tm (lung )Tj 0.0257 Tc 2.467 0 Td (volume )Tj 0.365 0.365 0.357 rg 0.0404 Tc 3.771 0 Td (on )Tj 0.023 Tc 1.68 0 Td (collateral )Tj 0.306 0.306 0.298 rg 0.0235 Tc 4.629 0 Td (ventilation )Tj 0.365 0.365 0.357 rg -0.035 Tc 7.9356 0 0 8 262.98 496.56 Tm (in )Tj 0.0212 Tc 8 0 0 8 274.54 496.56 Tm (the )Tj 0.306 0.306 0.298 rg 0.05 Tc 8.1459 0 0 8 58 487.93 Tm (dog)Tj 0.208 0.208 0.2 rg 0 Tc 8 0 0 8 70.88 487.93 Tm (. )Tj 0.306 0.306 0.298 rg /T1_2 1 Tf 0.611 0 Td (J )Tj /T1_3 1 Tf 0.0244 Tc 8.1 0 0 8.1 83.64 487.93 Tm (App/ )Tj ET BT /Suspect <>BDC 0.365 0.365 0.357 rg /T1_3 1 Tf 0.0027 Tc 8.1 0 0 8.1 102.3024 487.93 Tm (Physiol)Tj 0.51 0.514 0.498 rg 0 Tc 2.998 0 Td (: )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_3 1 Tf 0.0163 Tc 8.1 0 0 8.1 132.0699 487.93 Tm (Respirat )Tj -0.0152 Tc 3.911 0 Td (Environ )Tj 0.0066 Tc 3.556 0 Td (Exercise )Tj ET BT /Suspect <>BDC /T1_3 1 Tf -0.008 Tc 8.1 0 0 8.1 224.2317 487.93 Tm (Physiol, )Tj EMC /Suspect <>BDC /T1_0 1 Tf -0.0196 Tc 8 0 0 8 254.12 487.93 Tm (1980, )Tj EMC ET BT /T1_0 1 Tf 0.0126 Tc 8 0 0 8 274.528 487.93 Tm (49, )Tj 0.05 Tc 10.0688 0 0 8 57.97 479.28 Tm (9-)Tj 0.208 0.208 0.2 rg 0 Tc 8 0 0 8 69.8 479.28 Tm (1)Tj 0.306 0.306 0.298 rg -0.035 Tc 7.7556 0 0 8 73.33 479.28 Tm (5. )Tj 0.05 Tc 9.7215 0 0 8.4 58.96 469.69 Tm (ll. )Tj 0.0431 Tc 8 0 0 8 76.28 469.69 Tm (Hogg )Tj 0.0416 Tc 2.64 0 Td (JC, )Tj 0.0231 Tc 1.801 0 Td (Macklem )Tj 0.0197 Tc 4.32 0 Td (PT, )Tj 0.05 Tc 8.3216 0 0 8 160.73 469.69 Tm (Thur)Tj 0.208 0.208 0.2 rg 0 Tc 8 0 0 8 178.01 469.69 Tm (l)Tj 0.306 0.306 0.298 rg 0.0145 Tc 0.31 0 Td (bcck )Tj 0.0423 Tc 2.275 0 Td (WM.)Tj 0.577 0.577 0.565 rg 0 Tc 2.513 0 Td (-)Tj 0.208 0.208 0.2 rg 0.902 0 Td (T)Tj 0.306 0.306 0.298 rg 0.0209 Tc 0.727 0 Td (he )Tj 0.0159 Tc 1.32 0 Td (resistance )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.9033 0 0 8 277.84 469.69 Tm (of )Tj 0.306 0.306 0.298 rg 0.0305 Tc 8 0 0 8 57.52 461.05 Tm (collatera)Tj 0.208 0.208 0.2 rg 0 Tc 3.721 0 Td (l )Tj 0.306 0.306 0.298 rg 0.035 Tc 0.659 0 Td (channels )Tj 0.365 0.365 0.357 rg -0.035 Tc 7.9356 0 0 8 126.18 461.05 Tm (in )Tj 0.306 0.306 0.298 rg 0.0141 Tc 8 0 0 8 135.76 461.05 Tm (excised )Tj 0.041 Tc 3.549 0 Td (human )Tj -0.0002 Tc 3.473 0 Td (lungs. )Tj /T1_2 1 Tf 0 Tc 7.7 0 0 7.7 215.45 461.05 Tm (J )Tj 0.365 0.365 0.357 rg /T1_3 1 Tf -0.0171 Tc 8.1 0 0 8.1 223.52 461.05 Tm (Cfin )Tj 0.306 0.306 0.298 rg 0.0099 Tc 2.104 0 Td (Invest, )Tj /T1_0 1 Tf -0.0196 Tc 8 0 0 8 267.08 461.05 Tm (1969, )Tj 0.0126 Tc -26.189 -1.08 Td (48, )Tj 0.0303 Tc 1.62 0 Td (421-431. )Tj -0.0286 Tc -1.531 -1.141 Td (12)Tj 0.208 0.208 0.2 rg 0 Tc 0.975 0 Td (. )Tj 0.306 0.306 0.298 rg 0.019 Tc 1.275 0 Td (Eiseman )Tj -0.035 Tc 7.8194 0 0 8 107.01 443.28 Tm (B, )Tj 0.208 0.208 0.2 rg 0 Tc 8 0 0 8 115.65 443.28 Tm (B)Tj 0.306 0.306 0.298 rg 0.0268 Tc 0.722 0 Td (ryant )Tj -0.0078 Tc 2.456 0 Td (L, )Tj 0.0273 Tc 1.141 0 Td (Waltuch )Tj 0.05 Tc 11.2805 0 0 8 180.38 443.28 Tm (T.-)Tj 0.0243 Tc 8 0 0 8 197.25 443.28 Tm (Metabolism )Tj 0.05 Tc 9.4598 0 0 8 238.95 443.28 Tm (of )Tj 0.0433 Tc 8 0 0 8 248.15 443.28 Tm (vasomotor )Tj 0.0318 Tc -23.829 -1.14 Td (agents )Tj 0.365 0.365 0.357 rg -0.0304 Tc 3.191 0 Td (by )Tj 0.306 0.306 0.298 rg 0.0212 Tc 1.496 0 Td (the )Tj 0.365 0.365 0.357 rg 0.0215 Tc 1.674 0 Td (isolated )Tj 0.306 0.306 0.298 rg 0.024 Tc 3.73 0 Td (perfused )Tj 0.365 0.365 0.357 rg 0.0071 Tc 4.07 0 Td (lung. )Tj 0.306 0.306 0.298 rg /T1_2 1 Tf 0 Tc 7.7 0 0 7.7 190.97 434.16 Tm (J )Tj /T1_3 1 Tf 0.0018 Tc 8.1 0 0 8.1 199.04 434.16 Tm (Thorac )Tj 0.365 0.365 0.357 rg -0.0104 Tc 3.378 0 Td (Cardiovasc )Tj 0.0384 Tc 4.937 0 Td (Surg)Tj 0.51 0.514 0.498 rg 0 Tc 2.02 0 Td (, )Tj 0.306 0.306 0.298 rg /T1_0 1 Tf -0.0196 Tc 8 0 0 8 58.28 425.53 Tm (1964, )Tj 0.0126 Tc 2.491 0 Td (48, )Tj 0.365 0.365 0.357 rg 0.0231 Tc 1.614 0 Td (798-806. )Tj 0.306 0.306 0.298 rg -0.035 Tc 7.7937 0 0 8 58.29 416.41 Tm (13. )Tj 0.0452 Tc 8 0 0 8 75.81 416.41 Tm (Mead )Tj 0.0291 Tc 2.999 0 Td (J, )Tj 0.0301 Tc 1.316 0 Td (Takishima )Tj 0.05 Tc 8.0578 0 0 8 150.65 416.41 Tm (T, )Tj 0.0163 Tc 8 0 0 8 163.64 416.41 Tm (Leith )Tj 0.05 Tc 8.1158 0 0 8 186.2 416.41 Tm (D. )Tj 0.447 0.451 0.439 rg 0 Tc 8 0 0 8 199.59 416.41 Tm (-)Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0215 Tc 8 0 0 8 208.662 416.41 Tm (Stress )Tj EMC ET BT /T1_0 1 Tf 0.0293 Tc 8 0 0 8 233.214 416.41 Tm (distribution )Tj 0.0191 Tc 5.58 0 Td (in )Tj 0.0064 Tc -27.54 -1.141 Td (lungs: )Tj 0 Tc 2.879 0 Td (a )Tj 0.0415 Tc 0.909 0 Td (mode)Tj 0.208 0.208 0.2 rg 0 Tc 2.333 0 Td (l )Tj 0.306 0.306 0.298 rg 0.05 Tc 8.9033 0 0 8 111.76 407.28 Tm (of )Tj 0.0374 Tc 8 0 0 8 121.93 407.28 Tm (pulmonary )Tj 0.0127 Tc 5.029 0 Td (elasticity. )Tj /T1_2 1 Tf 0 Tc 4.381 0 Td (J )Tj /T1_3 1 Tf 0.0442 Tc 8.1 0 0 8.1 204.6 407.28 Tm (App/ )Tj ET BT /Suspect <>BDC /T1_3 1 Tf -0.008 Tc 8.1 0 0 8.1 223.7403 407.28 Tm (Physiof, )Tj EMC /Suspect <>BDC /T1_0 1 Tf -0.0346 Tc 8 0 0 8 254.12 407.28 Tm (1970, )Tj EMC ET BT /T1_0 1 Tf -0.0155 Tc 8 0 0 8 274.512 407.28 Tm (28, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0129 Tc 8 0 0 8 57.488 398.16 Tm (596)Tj 0.577 0.577 0.565 rg 0 Tc 1.502 0 Td (-)Tj 0.365 0.365 0.357 rg -0.0151 Tc 0.539 0 Td (608. )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf -0.035 Tc 7.3607 0 0 8 311.27 753.85 Tm (14. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0121 Tc 8 0 0 8 328.18 753.85 Tm (Sylvester )Tj EMC /Suspect <>BDC 0.05 Tc 8.3955 0 0 8 362.84 753.85 Tm (PT)Tj 0.447 0.451 0.439 rg 0 Tc 8 0 0 8 372.84 753.85 Tm (, )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0173 Tc 8 0 0 8 379.648 753.85 Tm (Menkes )Tj 0.05 Tc 8.077 0 0 8 410.36 753.85 Tm (HA, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0181 Tc 8 0 0 8 428.98 753.85 Tm (Stitik )Tj EMC ET BT 0.365 0.365 0.357 rg /T1_0 1 Tf 0.05 Tc 8.011 0 0 8 452.13 753.85 Tm (F. )Tj 0.577 0.577 0.565 rg 0 Tc 8 0 0 8 463.59 753.85 Tm (-)Tj 0.306 0.306 0.298 rg 0.0207 Tc 1.206 0 Td (Lung )Tj 0.0257 Tc 2.764 0 Td (volume )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.1466 0 0 8 524.56 753.85 Tm (and )Tj 0.0265 Tc 8 0 0 8 310.01 745.21 Tm (interdependence )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf -0.035 Tc 7.9356 0 0 8 368.1 745.21 Tm (in )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.0143 0 0 8 377.26 745.21 Tm (the )Tj -0.006 Tc 8 0 0 8 390.25 745.21 Tm (pig. )Tj /T1_2 1 Tf 0 Tc 7.8001 0 0 7.8001 405.53 745.21 Tm (J )Tj 0.365 0.365 0.357 rg /T1_3 1 Tf 0.0442 Tc 8.1 0 0 8.1 411.96 745.21 Tm (Appl )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_3 1 Tf 0.0027 Tc 8.1 0 0 8.1 431.1003 745.21 Tm (Physio/)Tj 0.51 0.514 0.498 rg 0 Tc 2.959 0 Td (, )Tj EMC /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf -0.0196 Tc 8 0 0 8 461 745.21 Tm (1975, )Tj EMC ET BT 0.365 0.365 0.357 rg /T1_0 1 Tf -0.0065 Tc 8 0 0 8 481.352 745.21 Tm (38, )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf -0.0115 Tc 8 0 0 8 493.832 745.21 Tm (395)Tj 0.577 0.577 0.565 rg 0 Tc 1.56 0 Td (-)Tj 0.306 0.306 0.298 rg 0.0018 Tc 0.487 0 Td (401. )Tj EMC /Suspect <>BDC -0.035 Tc 7.3607 0 0 8 311.27 736.09 Tm (15. )Tj EMC ET BT /T1_0 1 Tf 0.0002 Tc 8 0 0 8 328.76 736.09 Tm (Russell )Tj 0.05 Tc 10.197 0 0 8 354.18 736.09 Tm (JA.-)Tj 0.0144 Tc 8 0 0 8 374.84 736.09 Tm (Differential )Tj 0.365 0.365 0.357 rg 0.0306 Tc 5.096 0 Td (inhibitory )Tj -0.0064 Tc 4.499 0 Td (effect )Tj 0.05 Tc 8.9033 0 0 8 471.76 736.09 Tm (of )Tj 0.306 0.306 0.298 rg 0.032 Tc 8 0 0 8 480.89 736.09 Tm (isoproterenol )Tj 0.0404 Tc 5.999 0 Td (on )Tj 0.0327 Tc -27.36 -1.14 Td (contraction )Tj 0.05 Tc 8.9033 0 0 8 352.71 726.97 Tm (of )Tj 0.0348 Tc 8 0 0 8 363.28 726.97 Tm (canine )Tj 0.0192 Tc 3.18 0 Td (airways. )Tj 0.365 0.365 0.357 rg /T1_2 1 Tf 0 Tc 7.7 0 0 7.7 420.41 726.97 Tm (J )Tj 0.306 0.306 0.298 rg /T1_3 1 Tf 0.0442 Tc 8.1 0 0 8.1 428.28 726.97 Tm (Appl )Tj ET BT /Suspect <>BDC 0.365 0.365 0.357 rg /T1_3 1 Tf -0.003 Tc 8.1 0 0 8.1 448.3761 726.97 Tm (Physiol: )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_3 1 Tf 0.0079 Tc 8.1 0 0 8.1 479.5773 726.97 Tm (Respirat )Tj 0.365 0.365 0.357 rg -0.0152 Tc 3.97 0 Td (Environ )Tj 0.306 0.306 0.298 rg -0.0018 Tc -24.83 -1.067 Td (Exercise )Tj ET BT /Suspect <>BDC /T1_3 1 Tf 0.0004 Tc 8.1 0 0 8.1 341.3346 718.3273 Tm (Physiol, )Tj EMC ET BT /T1_0 1 Tf -0.0196 Tc 8 0 0 8 371.24 718.33 Tm (1984, )Tj -0.035 Tc 7.9596 0 0 8 391.57 718.33 Tm (57, )Tj ET BT /Suspect <>BDC 0.365 0.365 0.357 rg /T1_0 1 Tf 7.9146 0 0 8 403.54 718.33 Tm (801)Tj 0.577 0.577 0.565 rg 0 Tc 8 0 0 8 415.59 718.33 Tm (-)Tj 0.306 0.306 0.298 rg -0.0124 Tc 0.594 0 Td (807)Tj 0.447 0.451 0.439 rg 0 Tc 1.498 0 Td (. )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf -0.035 Tc 7.7937 0 0 8 310.77 709.21 Tm (16. )Tj 0.208 0.208 0.2 rg 0 Tc 8 0 0 8 328.24 709.21 Tm (G)Tj 0.306 0.306 0.298 rg 0.0422 Tc 0.78 0 Td (ertner )Tj 0 Tc 2.829 0 Td (A)Tj 0.447 0.451 0.439 rg 0.826 0 Td (, )Tj 0.208 0.208 0.2 rg 0.611 0 Td (B)Tj 0.306 0.306 0.298 rg 0.0238 Tc 0.662 0 Td (rombergcr-Barnea )Tj -0.035 Tc 7.8194 0 0 8 438.69 709.21 Tm (B, )Tj 0.0458 Tc 8 0 0 8 448.28 709.21 Tm (Dannenberg )Tj 0.05 Tc 8.1016 0 0 8 493.43 709.21 Tm (AM, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 8.099 0 0 8 512.09 709.21 Tm (Trayst)Tj 0.208 0.208 0.2 rg 0 Tc 8 0 0 8 534.63 709.21 Tm (\255)Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0422 Tc 8 0 0 8 310.07 700.562 Tm (man )Tj -0.0137 Tc 2.156 0 Td (R, )Tj 0.0293 Tc 1.261 0 Td (Menkes )Tj 0 Tc 3.539 0 Td (H)Tj 0.447 0.451 0.439 rg 0.05 Tc 13.8213 0 0 8 372.67 700.56 Tm (.-)Tj 0.306 0.306 0.298 rg 0.0129 Tc 8 0 0 8 383.48 700.56 Tm (Responses )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.9033 0 0 8 420.4 700.56 Tm (of )Tj 0.306 0.306 0.298 rg 8.0143 0 0 8 429.58 700.56 Tm (the )Tj 0.0327 Tc 8 0 0 8 442.01 700.56 Tm (lung )Tj 0.0325 Tc 2.11 0 Td (periphery )Tj 0.05 Tc 8.1489 0 0 8 493.9 700.56 Tm (to )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0193 Tc 8 0 0 8 503.72 700.56 Tm (1.0 )Tj EMC ET BT 0.365 0.365 0.357 rg /T1_0 1 Tf 0.05 Tc 8.5907 0 0 8 514.57 700.56 Tm (p.p)Tj 0.208 0.208 0.2 rg 0 Tc 8 0 0 8 526.4 700.56 Tm (.)Tj 0.306 0.306 0.298 rg 0.259 0 Td (m)Tj 0.208 0.208 0.2 rg 0.881 0 Td (. )Tj 0.365 0.365 0.357 rg 0.0169 Tc -28.19 -1.14 Td (ozone. )Tj 0.306 0.306 0.298 rg /T1_2 1 Tf 0 Tc 3.001 0 Td (J )Tj /T1_3 1 Tf 0.0244 Tc 8.1 0 0 8.1 340.92 691.44 Tm (Appf )Tj ET BT /Suspect <>BDC /T1_3 1 Tf -0.003 Tc 8.1 0 0 8.1 358.6185 691.44 Tm (Physiof: )Tj EMC ET BT /T1_3 1 Tf 0.0079 Tc 8.1 0 0 8.1 388.3779 691.44 Tm (Respirat )Tj -0.0152 Tc 3.733 0 Td (Environ )Tj 0.0389 Tc 3.437 0 Td (Exer)Tj 0.447 0.451 0.439 rg 0 Tc 2 0 Td (c)Tj 0.306 0.306 0.298 rg 0.0169 Tc 0.41 0 Td (ise )Tj ET BT /Suspect <>BDC /T1_3 1 Tf 0.0004 Tc 8.1 0 0 8.1 477.6561 691.44 Tm (Physiof, )Tj EMC ET BT /T1_0 1 Tf -0.0046 Tc 8 0 0 8 507.08 691.44 Tm (1983, )Tj 0.365 0.365 0.357 rg -0.0079 Tc 2.541 0 Td (56, )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0231 Tc 8 0 0 8 310 682.8 Tm (770-776. )Tj EMC /Suspect <>BDC 0.306 0.306 0.298 rg 0.0487 Tc 0.005 -2.1 Td (RESUME: )Tj EMC ET BT /T1_0 1 Tf 0.0392 Tc 8 0 0 8 350.36 666 Tm (La )Tj 0.0175 Tc 1.564 0 Td (ventilation )Tj 0.365 0.365 0.357 rg 0.023 Tc 4.851 0 Td (collatera)Tj 0.208 0.208 0.2 rg 0 Tc 3.661 0 Td (l)Tj 0.306 0.306 0.298 rg 0.239 0 Td (e )Tj 0.0352 Tc 0.851 0 Td (permet )Tj 0.0285 Tc 3.29 0 Td (des )Tj 0.0284 Tc 1.739 0 Td (echanges )Tj 0.0251 Tc 4.201 0 Td (gazeux )Tj 0.0309 Tc -25.501 -1.08 Td (entre )Tj 0.0288 Tc 2.53 0 Td (une )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0259 Tc 8 0 0 8 344.64 657.36 Tm (unite )Tj EMC ET BT /T1_0 1 Tf -0.0066 Tc 8 0 0 8 364.248 657.36 Tm (isolee )Tj 0.026 Tc 2.64 0 Td (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.2698 0 0 8 396.43 657.36 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0085 Tc 8 0 0 8 405.11 657.36 Tm (voie )Tj 0.0348 Tc 2.103 0 Td (bronchique )Tj 0.05 Tc 8.4273 0 0 8 462.73 657.36 Tm (par )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0444 Tc 8 0 0 8 477.04 657.36 Tm (obstruction )Tj EMC ET BT /T1_0 1 Tf 0.0201 Tc 8 0 0 8 519.28 657.36 Tm (ct )Tj 0.365 0.365 0.357 rg -0.035 Tc 7.5601 0 0 8 528.44 657.36 Tm (Jes )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf -0.0082 Tc 8 0 0 8 310.08 648.24 Tm (uni)Tj 0.208 0.208 0.2 rg 0 Tc 1.317 0 Td (t)Tj 0.306 0.306 0.298 rg 0.0278 Tc 0.292 0 Td (es )Tj EMC ET BT /T1_0 1 Tf 0.029 Tc 8 0 0 8 331.68 648.24 Tm (pulmonaires )Tj 0.0223 Tc 5.449 0 Td (adjaccntes. )Tj 0.05 Tc 8.0446 0 0 8 414.16 648.24 Tm (Comme )Tj ET BT /Suspect <>BDC 0.365 0.365 0.357 rg /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8 442.99 648.24 Tm (Ia )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0164 Tc 8 0 0 8 451.21 648.24 Tm (presence )Tj 0.026 Tc 3.83 0 Td (de )Tj 0.0144 Tc 1.207 0 Td (muscles )Tj -0.0216 Tc 3.536 0 Td (Jisses )Tj 0.05 Tc 8.3101 0 0 8 309.52 639.61 Tm (au )Tj 0.365 0.365 0.357 rg -0.0079 Tc 8 0 0 8 320.05 639.61 Tm (scin )Tj 0.05 Tc 8.2927 0 0 8 334.96 639.61 Tm (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0187 Tc 8 0 0 8 345.55 639.61 Tm (Ia )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf 0.044 Tc 8 0 0 8 353.774 639.61 Tm (paroi )Tj 0.026 Tc 2.51 0 Td (de )Tj 0.365 0.365 0.357 rg 0.0025 Tc 1.199 0 Td (ccs )Tj 0.306 0.306 0.298 rg -0.0009 Tc 1.569 0 Td (voies )Tj 0.0184 Tc 2.391 0 Td (eollaterale)Tj 0.447 0.451 0.439 rg 0 Tc 4.376 0 Td (s )Tj 0.365 0.365 0.357 rg 0.604 0 Td (a )Tj 0.306 0.306 0.298 rg 0.05 Tc 8.2998 0 0 8 461.77 639.61 Tm (pu )Tj ET BT /Suspect <>BDC 0.365 0.365 0.357 rg /T1_0 1 Tf 0.0479 Tc 8 0 0 8 472.24 639.61 Tm (etre )Tj EMC /Suspect <>BDC 0.306 0.306 0.298 rg 0.0381 Tc 1.861 0 Td (demontree, )Tj EMC ET BT 0.365 0.365 0.357 rg /T1_0 1 Tf 0.0206 Tc 8 0 0 8 528.48 639.61 Tm (un )Tj 0.306 0.306 0.298 rg 0.0324 Tc -27.37 -1.141 Td (controle )Tj 0.447 0.451 0.439 rg 0 Tc 3.959 0 Td (')Tj 0.306 0.306 0.298 rg 0.0391 Tc 0.31 0 Td (moteur' )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.2998 0 0 8 373.36 630.48 Tm (du )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf 8.1356 0 0 8 385.84 630.48 Tm (deb)Tj 0.208 0.208 0.2 rg 0 Tc 8 0 0 8 398.33 630.48 Tm (i)Tj 0.306 0.306 0.298 rg 0.306 0 Td (t )Tj EMC /Suspect <>BDC 0.023 Tc 0.712 0 Td (collateral )Tj EMC ET BT 0.365 0.365 0.357 rg /T1_0 1 Tf 0.0153 Tc 8 0 0 8 441.962 630.48 Tm (semble )Tj 0.306 0.306 0.298 rg 0.018 Tc 3.375 0 Td (possible. )Tj 0.365 0.365 0.357 rg -0.0208 Tc 4.254 0 Td (La )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0345 Tc 8 0 0 8 514.922 630.48 Tm (stimu\255)Tj EMC ET BT /T1_0 1 Tf 0.0282 Tc 8 0 0 8 309.522 621.36 Tm (lation )Tj 0.306 0.306 0.298 rg 0.0285 Tc 2.7 0 Td (des )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0174 Tc 8 0 0 8 345.106 621.36 Tm (recepteurs )Tj EMC ET BT 0.365 0.365 0.357 rg /T1_0 1 Tf 0.0198 Tc 8 0 0 8 381.514 621.36 Tm (eholinergiques )Tj 0.306 0.306 0.298 rg 0.0295 Tc 6.421 0 Td (iotrasegmentaires )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.2537 0 0 8 494.89 621.36 Tm (peut )Tj 0.0236 Tc 8 0 0 8 512.08 621.36 Tm (exercer )Tj 0.306 0.306 0.298 rg 0.05 Tc 8.2333 0 0 8 309.6 612.73 Tm (un )Tj 0.365 0.365 0.357 rg 0.041 Tc 8 0 0 8 320.56 612.73 Tm (controle )Tj 0.05 Tc 8.1435 0 0 8 351.73 612.73 Tm (sur )Tj 0.0341 Tc 8 0 0 8 364.72 612.73 Tm (ce )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.028 Tc 8 0 0 8 374.808 612.73 Tm (debit )Tj EMC ET BT /T1_0 1 Tf 0.0197 Tc 8 0 0 8 394.48 612.73 Tm (collateral. )Tj 0.306 0.306 0.298 rg 0.0375 Tc 4.626 0 Td (Mais )Tj 0.365 0.365 0.357 rg -0.0069 Tc 2.455 0 Td (les )Tj 0.306 0.306 0.298 rg 0.024 Tc 1.447 0 Td (recepteurs )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0197 Tc 8 0 0 8 500.072 612.73 Tm (cholinergi\255)Tj EMC ET BT /T1_0 1 Tf 0.0327 Tc 8 0 0 8 309.04 603.61 Tm (qucs )Tj 0.0181 Tc 2.275 0 Td (situes )Tj 0.05 Tc 8.0284 0 0 8 348.41 603.61 Tm (dans )Tj 0.365 0.365 0.357 rg -0.035 Tc 7.9707 0 0 8 367.13 603.61 Tm (lcs )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0269 Tc 8 0 0 8 378.24 603.61 Tm (unites )Tj EMC ET BT 0.365 0.365 0.357 rg /T1_0 1 Tf 0.0259 Tc 8 0 0 8 400.72 603.61 Tm (adjacentes )Tj 0.306 0.306 0.298 rg 0.0279 Tc 4.68 0 Td (ont-ils )Tj 0.365 0.365 0.357 rg 0.0384 Tc 3 0 Td (eux )Tj 0.306 0.306 0.298 rg 0.0133 Tc 1.86 0 Td (aussi )Tj 0.05 Tc 8.0913 0 0 8 496.32 603.61 Tm (une )Tj 8.2173 0 0 8 511.21 603.61 Tm (part )Tj 8.7609 0 0 8 527.44 603.61 Tm (du )Tj 0.365 0.365 0.357 rg 0.0255 Tc 8 0 0 8 309.04 594.97 Tm (controle? )Tj 0.306 0.306 0.298 rg 0.05 Tc 8.0671 0 0 8 343.24 594.97 Tm (Nous )Tj 0.365 0.365 0.357 rg 0.0348 Tc 8 0 0 8 364.24 594.97 Tm (avons )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0256 Tc 8 0 0 8 386.864 594.97 Tm (tente )Tj EMC ET BT /T1_0 1 Tf 0.0207 Tc 8 0 0 8 406.016 594.97 Tm (d'elueide)Tj 0.208 0.208 0.2 rg 0 Tc 3.788 0 Td (r )Tj 0.306 0.306 0.298 rg 0.0341 Tc 0.651 0 Td (ce )Tj 0.0438 Tc 1.271 0 Td (point )Tj 0.0368 Tc (en )Tj 0.0254 Tc 3.899 0 Td (utilisant )Tj 0.037 Tc 3.77 0 Td (chez )Tj 0.0152 Tc 2.281 0 Td (le )Tj 0.0193 Tc -27.781 -1.14 Td (chien )Tj -0.035 Tc 7.9307 0 0 8 331.15 585.85 Tm (Ia )Tj 0.0239 Tc 8 0 0 8 340.79 585.85 Tm (mesure )Tj 0.026 Tc 3.473 0 Td (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.2698 0 0 8 380.59 585.85 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0093 Tc 8 0 0 8 390.71 585.85 Tm (resistance )Tj 0.0244 Tc 4.491 0 Td (collaterale )Tj 0.05 Tc 8.4273 0 0 8 465.61 585.85 Tm (par )Tj 0.208 0.208 0.2 rg 0 Tc 8 0 0 8 480.91 585.85 Tm (I)Tj 0.365 0.365 0.357 rg 0.296 0 Td (a )Tj 0.306 0.306 0.298 rg 0.0324 Tc 0.967 0 Td (technique )Tj 0.05 Tc 8.7609 0 0 8 527.44 585.85 Tm (du )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0402 Tc 8 0 0 8 309.04 576.73 Tm (catheter )Tj EMC /Suspect <>BDC 0.0166 Tc 3.791 0 Td (bloque. )Tj EMC ET BT 0.365 0.365 0.357 rg /T1_0 1 Tf 0.0489 Tc 8 0 0 8 366.64 576.73 Tm (Cette )Tj 0.306 0.306 0.298 rg 0.0174 Tc 2.648 0 Td (technique )Tj 0.0232 Tc 4.384 0 Td (permet )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8 448.75 576.73 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0359 Tc 8 0 0 8 457.43 576.73 Tm (mesure )Tj 0.026 Tc 3.353 0 Td (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8 495.31 576.73 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0226 Tc 8 0 0 8 503.51 576.73 Tm (resistance )Tj 0.365 0.365 0.357 rg 0.015 Tc -24.309 -1.08 Td (colla)Tj 0.208 0.208 0.2 rg 0 Tc 2.048 0 Td (t)Tj 0.365 0.365 0.357 rg 0.0222 Tc 0.292 0 Td (erale, )Tj 0.306 0.306 0.298 rg 0.026 Tc 2.581 0 Td (de )Tj ET BT /Suspect <>BDC 0.365 0.365 0.357 rg /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8 358.51 568.09 Tm (Ia )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0485 Tc 8 0 0 8 366.16 568.09 Tm (constante )Tj 0.026 Tc 4.381 0 Td (de )Tj 0.365 0.365 0.357 rg 0.0191 Tc 1.266 0 Td (temps )Tj 0.026 Tc (de )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8 443.47 568.09 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0295 Tc 8 0 0 8 451.67 568.09 Tm (ventilation )Tj 0.0304 Tc 4.791 0 Td (collaterale )Tj 0.05 Tc 8.2998 0 0 8 527.44 568.09 Tm (du )Tj 0.0194 Tc 8 0 0 8 309.01 558.97 Tm (segment )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.3173 0 0 8 338.31 558.97 Tm (et )Tj 0.306 0.306 0.298 rg 8.2927 0 0 8 346.48 558.97 Tm (de )Tj 0.365 0.365 0.357 rg 0.0333 Tc 8 0 0 8 356.53 558.97 Tm (sa )Tj 0.306 0.306 0.298 rg 0.0308 Tc 1.084 0 Td (compliance )Tj -0.0069 Tc 5.1 0 Td (effective. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0197 Tc 8 0 0 8 437.754 558.97 Tm (Aprcs )Tj EMC ET BT /T1_0 1 Tf 0.0328 Tc 8 0 0 8 459.778 558.97 Tm (induction )Tj 0.05 Tc 8.1714 0 0 8 494.32 558.97 Tm (d'un )Tj 0.365 0.365 0.357 rg 0.0409 Tc 8 0 0 8 511.57 558.97 Tm (spasme )Tj 0.306 0.306 0.298 rg 0.0239 Tc -25.316 -1.14 Td (cholinergique )Tj 0.05 Tc 8.4273 0 0 8 358.57 549.85 Tm (par )Tj 0.365 0.365 0.357 rg 0.021 Tc 8 0 0 8 372.88 549.85 Tm (aerosol )Tj 0.05 Tc 8.2927 0 0 8 400.24 549.85 Tm (de )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0096 Tc 8 0 0 8 411.83 549.85 Tm (mecholyl )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.0284 0 0 8 445.37 549.85 Tm (dans )Tj -0.035 Tc 7.3018 0 0 8 464.6 549.85 Tm (Je )Tj 0.05 Tc 8.0501 0 0 8 473.77 549.85 Tm (poumon )Tj 0.0269 Tc 8 0 0 8 505.84 549.85 Tm (adjacent, )Tj -0.0275 Tc -24.6 -1.08 Td (ces )Tj 0.0409 Tc 1.511 0 Td (parametres )Tj 0.05 Tc 8.4919 0 0 8 360.88 541.21 Tm (ont )Tj ET BT /Suspect <>BDC 0.365 0.365 0.357 rg /T1_0 1 Tf -0.0016 Tc 8 0 0 8 374.8 541.21 Tm (ete )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf -0.0009 Tc 8 0 0 8 386.872 541.21 Tm (mesures; )Tj -0.0015 Tc 3.893 0 Td (des )Tj 0.0151 Tc 1.627 0 Td (mesures )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.4919 0 0 8 460.24 541.21 Tm (ont )Tj 0.306 0.306 0.298 rg 0.0318 Tc 8 0 0 8 473.68 541.21 Tm (ensuite )Tj ET BT /Suspect <>BDC 0.365 0.365 0.357 rg /T1_0 1 Tf 0.05 Tc 8.1078 0 0 8 499.59 541.21 Tm (ete )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0175 Tc 8 0 0 8 511.67 541.21 Tm (refaites )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0308 Tc 8 0 0 8 309.038 532.09 Tm (apres )Tj EMC ET BT /T1_0 1 Tf -0.0015 Tc 8 0 0 8 332.566 532.09 Tm (des )Tj 0.365 0.365 0.357 rg 0.017 Tc 2.04 0 Td (injections )Tj 0.306 0.306 0.298 rg 0.0166 Tc 4.749 0 Td (ulterieures )Tj 0.0384 Tc 5.031 0 Td (d'isoprotcrenol )Tj 0.0404 Tc 7.199 0 Td (ou )Tj 0.0486 Tc 1.741 0 Td (d'atropine. )Tj 0.0222 Tc -23.636 -1.081 Td (L'aerosol )Tj 0.365 0.365 0.357 rg 0.026 Tc 4.496 0 Td (de )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0096 Tc 8 0 0 8 358.062 523.442 Tm (mecholyl )Tj EMC ET BT 0.365 0.365 0.357 rg /T1_0 1 Tf 0.0297 Tc 8 0 0 8 393.51 523.442 Tm (augmente )Tj ET BT /Suspect <>BDC 0.306 0.306 0.298 rg /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8 430.99 523.44 Tm (Ia )Tj EMC /Suspect <>BDC 0.365 0.365 0.357 rg 0.0159 Tc 8 0 0 8 442.07 523.44 Tm (resistance )Tj EMC /Suspect <>BDC 0.0151 Tc 4.611 0 Td (coUaterale )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.3173 0 0 8 519.27 523.44 Tm (et )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8 530.35 523.44 Tm (Ia )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0485 Tc 8 0 0 8 308.56 514.33 Tm (constante )Tj 0.05 Tc 8.2927 0 0 8 343.12 514.33 Tm (de )Tj 0.0133 Tc 8 0 0 8 353.74 514.33 Tm (temps, )Tj 0.365 0.365 0.357 rg 0.0341 Tc 2.993 0 Td (ce )Tj 0.0266 Tc 1.141 0 Td (qui )Tj 0.306 0.306 0.298 rg 0.0469 Tc 1.687 0 Td (montre )Tj 0.0336 Tc 3.293 0 Td (que )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0187 Tc 8 0 0 8 441.068 514.33 Tm (Ia )Tj EMC ET BT 0.365 0.365 0.357 rg /T1_0 1 Tf 0.0331 Tc 8 0 0 8 449.164 514.33 Tm (stimulation )Tj 0.306 0.306 0.298 rg 0.0239 Tc 5.104 0 Td (cholinergique )Tj 0.0285 Tc -22.679 -1.14 Td (des )Tj 0.365 0.365 0.357 rg 0.021 Tc 1.975 0 Td (segments )Tj 0.306 0.306 0.298 rg 0.0398 Tc 4.384 0 Td (environoants )Tj 0.032 Tc 6.18 0 Td (entraine )Tj 0.0288 Tc 4.09 0 Td (une )Tj 0.365 0.365 0.357 rg 0.0367 Tc 2.03 0 Td (constriction )Tj 0.306 0.306 0.298 rg -0.0015 Tc 5.701 0 Td (des )Tj -0.0009 Tc 1.987 0 Td (voies )Tj ET BT /Suspect <>BDC 0.365 0.365 0.357 rg /T1_0 1 Tf 0.0034 Tc 8 0 0 8 308.548 496.562 Tm (coUaterales. )Tj EMC ET BT /T1_0 1 Tf -0.035 Tc 8.1134 0 0 8.6 351.8 496.56 Tm (Le )Tj 0.306 0.306 0.298 rg 0.0103 Tc 8 0 0 8 362.79 496.56 Tm (fait )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.0481 0 0 8 376.24 496.56 Tm (qu'unc )Tj 0.0076 Tc 8 0 0 8 402.23 496.56 Tm (reversibilite )Tj 0.306 0.306 0.298 rg 0.0409 Tc 5.16 0 Td (rapide )Tj 0.365 0.365 0.357 rg 0.05 Tc 8.3173 0 0 8 466.95 496.56 Tm (et )Tj 0.306 0.306 0.298 rg 0.0286 Tc 8 0 0 8 475.6 496.56 Tm (complete )Tj 0.0323 Tc 4.136 0 Td (survient )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.0088 Tc 8 0 0 8 308.56 487.44 Tm (aprt!s )Tj EMC ET BT /T1_0 1 Tf 0.0153 Tc 8 0 0 8 333.528 487.44 Tm (injection )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0341 Tc 8 0 0 8 369.048 487.44 Tm (d'isoproterenol )Tj EMC ET BT /T1_0 1 Tf 0.05 Tc 8.3916 0 0 8 427.6 487.44 Tm (ou )Tj 0.0484 Tc 8 0 0 8 442.97 487.44 Tm (d'atropinc )Tj 0.0366 Tc 5.22 0 Td (demontre )Tj 0.0336 Tc 4.92 0 Td (que )Tj 0.0362 Tc -26.904 -1.139 Td (!'obs)Tj 0.208 0.208 0.2 rg 0 Tc 2.07 0 Td (t)Tj 0.306 0.306 0.298 rg 0.0284 Tc 0.301 0 Td (ruction )Tj 0.05 Tc 8.2927 0 0 8 354.16 478.33 Tm (de )Tj ET BT /Suspect <>BDC 0.365 0.365 0.357 rg /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8 364.75 478.33 Tm (Ia )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0085 Tc 8 0 0 8 372.95 478.33 Tm (voie )Tj 0.365 0.365 0.357 rg 0.0304 Tc 1.971 0 Td (collaterale )Tj 0.306 0.306 0.298 rg 0.05 Tc 8.0724 0 0 8 426.16 478.33 Tm (est )Tj 0.033 Tc 8 0 0 8 437.69 478.33 Tm (due )Tj ET BT /Suspect <>BDC 0.365 0.365 0.357 rg /T1_0 1 Tf 0 Tc 13.4 0 0 13.4 452.02 478.33 Tm (a )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0206 Tc 8 0 0 8 458.88 478.33 Tm (un )Tj 0.365 0.365 0.357 rg 0.0409 Tc 1.306 0 Td (spasme )Tj 0.208 0.208 0.2 rg 0 Tc 3.365 0 Td (d)Tj 0.365 0.365 0.357 rg -0.0322 Tc 0.599 0 Td (es )Tj 0.306 0.306 0.298 rg 0.0044 Tc 1.149 0 Td (muscles )Tj -0.0198 Tc -25.147 -1.08 Td (lisses, )Tj 0.365 0.365 0.357 rg 0 Tc 2.519 0 Td (e)Tj 0.208 0.208 0.2 rg 0.487 0 Td (t )Tj 0.306 0.306 0.298 rg 0.0317 Tc 0.601 0 Td (non )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 11.8 0 0 11.8 352.68 469.69 Tm (a )Tj EMC ET BT /T1_0 1 Tf -0.0015 Tc 8 0 0 8 358.49 469.69 Tm (des )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.026 Tc 8 0 0 8 371.53 469.69 Tm (phenomenes )Tj EMC ET BT /T1_0 1 Tf 0.035 Tc 8 0 0 8 414.642 469.69 Tm (comme )Tj 0.0332 Tc 3.361 0 Td (l'oedeme )Tj 0.05 Tc 8.2927 0 0 8 473.2 469.69 Tm (de )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8 483.31 469.69 Tm (Ia )Tj EMC ET BT /T1_0 1 Tf 0.0389 Tc 8 0 0 8 491.03 469.69 Tm (muqueuse )Tj 0.05 Tc 8.3916 0 0 8 527.44 469.69 Tm (ou )Tj -0.0015 Tc 8 0 0 8 308.57 460.56 Tm (des )Tj 0.0454 Tc 1.93 0 Td (bouchons )Tj 0.026 Tc 4.67 0 Td (de )Tj 0.0171 Tc 1.567 0 Td (mucus. )Tj -0.0208 Tc 3.596 0 Td (La )Tj 0.0308 Tc 1.615 0 Td (compliance )Tj 0.05 Tc 8.2998 0 0 8 458.8 460.56 Tm (du )Tj 0.0294 Tc 8 0 0 8 471.73 460.56 Tm (segment )Tj 0.365 0.365 0.357 rg 0.0309 Tc 4.095 0 Td (bloq)Tj 0.208 0.208 0.2 rg 0 Tc 1.979 0 Td (u)Tj 0.365 0.365 0.357 rg 0.47 0 Td (e )Tj 0.306 0.306 0.298 rg 1.02 0 Td (a )Tj 0.0146 Tc -27.96 -1.079 Td (egalement )Tj 0.365 0.365 0.357 rg 0.0258 Tc 4.801 0 Td (diminue )Tj 0.05 Tc 8.0745 0 0 8 378.64 451.93 Tm (durant )Tj 0.306 0.306 0.298 rg -0.035 Tc 7.8836 0 0 8 406.01 451.93 Tm (le )Tj 0.365 0.365 0.357 rg 0.0409 Tc 8 0 0 8 415.09 451.93 Tm (spasmc )Tj 0.0239 Tc 3.604 0 Td (cholinergique )Tj 0.306 0.306 0.298 rg 0.05 Tc 8.2998 0 0 8 494.32 451.93 Tm (du )Tj 8.0501 0 0 8 507.37 451.93 Tm (poumon )Tj 0.365 0.365 0.357 rg 0.0275 Tc 8 0 0 8 308.56 442.81 Tm (avoisinant, )Tj 0.306 0.306 0.298 rg 0.0341 Tc 5.04 0 Td (cc )Tj 0.365 0.365 0.357 rg 0.0266 Tc 1.321 0 Td (qui )Tj 0.0297 Tc 1.81 0 Td (peut )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.0198 Tc 8 0 0 8 391.6 442.81 Tm (et)Tj 0.208 0.208 0.2 rg 0 Tc 0.849 0 Td (r)Tj 0.365 0.365 0.357 rg 0.291 0 Td (e )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0459 Tc 8 0 0 8 407.44 442.81 Tm (attribuc )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0 Tc 12.4 0 0 12.4 437.63 442.81 Tm (a )Tj EMC ET BT /T1_0 1 Tf 0.0321 Tc 8 0 0 8 444.89 442.81 Tm (l'interdepeodance )Tj 0.365 0.365 0.357 rg 0.0459 Tc 7.919 0 Td (entre )Tj 0.0341 Tc 2.58 0 Td (ce )Tj 0.306 0.306 0.298 rg 0.0194 Tc -27.544 -1.14 Td (segment )Tj 0.05 Tc 8.3173 0 0 8 342.63 433.69 Tm (et )Tj 0.365 0.365 0.357 rg -0.035 Tc 7.8836 0 0 8 355.61 433.69 Tm (le )Tj 0.306 0.306 0.298 rg 0.05 Tc 8.0501 0 0 8 367.69 433.69 Tm (poumon )Tj 0.0361 Tc 8 0 0 8 402.64 433.69 Tm (environnant. )Tj 0.0378 Tc 6.3 0 Td (Cct )Tj 0.365 0.365 0.357 rg 0.0127 Tc 2.22 0 Td (effet )Tj 0 Tc 2.7 0 Td (a )Tj 0.306 0.306 0.298 rg 0.0133 Tc 1.32 0 Td (aussi )Tj ET BT /Suspect <>BDC 0.365 0.365 0.357 rg /T1_0 1 Tf 0.05 Tc 8.1078 0 0 8 525.99 433.69 Tm (ete )Tj EMC ET BT 0.306 0.306 0.298 rg /T1_0 1 Tf 0.0288 Tc 8 0 0 8 308.57 425.05 Tm (immediatcment )Tj 0.0198 Tc 7.14 0 Td (inhibe )Tj 0.05 Tc 8.4273 0 0 8 391.69 425.05 Tm (par )Tj -0.0069 Tc 8 0 0 8 407.93 425.05 Tm (les )Tj 0.0336 Tc 1.69 0 Td (bronchodilatateurs. )Tj ET BT /Suspect <>BDC /T1_0 1 Tf 0.05 Tc 8.0656 0 0 8 492.88 425.05 Tm (On )Tj EMC ET BT /T1_0 1 Tf 0.0497 Tc 8 0 0 8 508.33 425.05 Tm (peut )Tj 0.0368 Tc 2.449 0 Td (en )Tj 0.0179 Tc -27.48 -1.14 Td (concluse )Tj 0.0336 Tc 3.961 0 Td (que )Tj 0.208 0.208 0.2 rg 0 Tc 1.864 0 Td (J)Tj 0.306 0.306 0.298 rg 0.0278 Tc 0.235 0 Td (es )Tj 0.0174 Tc 1.209 0 Td (rccepteurs )Tj 0.0199 Tc 4.611 0 Td (cholinergiques )Tj -0.0015 Tc 6.481 0 Td (des )Tj 0.0044 Tc 1.687 0 Td (muscles )Tj -0.0098 Tc 3.592 0 Td (lisses )Tj 0.365 0.365 0.357 rg 0.03 Tc 2.455 0 Td (situes )Tj 0.306 0.306 0.298 rg 0.05 Tc 8.1435 0 0 8 308.05 406.81 Tm (sur )Tj -0.035 Tc 7.8836 0 0 8 321.53 406.81 Tm (le )Tj 0.0301 Tc 8 0 0 8 329.27 406.81 Tm (versant )Tj 0.0235 Tc 3.351 0 Td (cxterne )Tj 0.0285 Tc 3.361 0 Td (des )Tj 0.0382 Tc 1.679 0 Td (canaux )Tj 0.365 0.365 0.357 rg 0.0264 Tc 3.36 0 Td (collateraux )Tj 0.306 0.306 0.298 rg 0.0343 Tc 4.991 0 Td (peuvent )Tj 0.0283 Tc 3.649 0 Td (aussi )Tj 0.365 0.365 0.357 rg 0.0236 Tc 2.4 0 Td (exercer )Tj 0.306 0.306 0.298 rg 0.0206 Tc -25.37 -1.14 Td (un )Tj 0.0324 Tc 1.37 0 Td (controle )Tj 0.05 Tc 8.1435 0 0 8 350.29 397.69 Tm (sur )Tj ET BT /Suspect <>BDC /T1_0 1 Tf -0.035 Tc 7.9307 0 0 8 363.79 397.69 Tm (Ia )Tj EMC ET BT 0.365 0.365 0.357 rg /T1_0 1 Tf 0.0175 Tc 8 0 0 8 372.95 397.69 Tm (ventilation )Tj 0.0244 Tc 4.851 0 Td (collaterale )Tj 0.05 Tc 8.2998 0 0 8 449.2 397.69 Tm (du )Tj 0.306 0.306 0.298 rg 0.0437 Tc 8 0 0 8 460.81 397.69 Tm (poumon. )Tj ET endstream endobj 67 0 obj <>stream jP ftypjp2 jp2 jpxbjpx rreq@ --jp2hihdrcolrjp2cOQ/R \#B@HHPHHPHHPHHP((( .߇JMK@ZA3rCW%GDY<[BCʭ&YPҤeARSc]"L֐tOpd X7  ONγy]qm (ϚͨW`덐HZҵSz^-Т`( $U i iu*_1#0 7 Gz?Ocó.Wˆ}=aKV|U6$* _r@@uM,P1R% R_@"~+2iһNM!8DWڪץX6Jo1fD,HIWJJ6n^:qsNUkD;_W>/]-!|BNlz*{>E3kDSF-xjL0ȩY女M!"arWYi#H xȅV|Ϥ:IQ̷CpNmՍʌ/UN|R"dF Ӽ B)"/V-.$&P\}u95%Gn` ClL )=ղ aש|%7DNcq+j ge۬On1 0}vWY-uNfӎc?cѮy!#rko5Ws%PDwE`q\]hkѥsV?eY}'6Q$ *rkc@%kSG:+$u &M Yޫ^''Fv ߅M&!{cEspLn=HߪF D#Od|x 16 U){!<~;kuuQ?bڮ_W&qA$?WnR'׋BqwYSfL"(]/;囹NH,r>.bmW9tS? 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