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BT
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T*
(Gulsvik.)Tj
/F4 1 Tf
3.6041 0 TD
0 Tw
(#)Tj
/F3 1 Tf
0.999 0 TD
[(ERS)-334.2(Journals)-335.6(Ltd)-328.2(1999.)]TJ
/F5 1 Tf
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[(ABSTRACT)66.7(:)-240.7(Reduced)-247.7(single-brea)8.5(th)-245.1(transfer)-243.5(factors)-245.7(of)-246.5(the)-244.4(lung)-244.1(for)-233.2(carbon)-246.6(monoxide)]TJ
T*
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T*
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/F6 1 Tf
25.7532 0 TD
(T)Tj
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(L,CO)Tj
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[(level)-336.9(in)-341.4(a)-334.6(general)]TJ
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T*
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T*
[(dardized)-233.6(spirometric)-227.1(and)]TJ
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10.907 0 TD
(T)Tj
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(L,CO)Tj
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[(measure)10.3(ments)-232.4(and)-235.9(clinical)-237.5(examination.)-234.3(Associations)]TJ
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T*
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/F6 1 Tf
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(T)Tj
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(L,CO)Tj
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/F6 1 Tf
T*
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(L,CO)Tj
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5.052 0.2213 TD
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T*
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/F3 1 Tf
T*
[(Eur)-331.9(Respir)-333.8(J)-334.4(1999;)-333.5(14:)-334.6(1320\2611325.)]TJ
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[(Dept)-315.5(of)-323.2(Thoraci)11.5(c)-324.1(Medicine,)-310.1(University)-316.2(of)]TJ
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[(Berge)14.8(n,)-331.2(Ber)16.7(gen,)-333.1(Norway)72.5(.)]TJ
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[(Corresponde)11.8(nce:)-333.4(I.)-331.4(W)76.3(elle)]TJ
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[(Dept)-329.8(of)-330.3(Thoracic)-326.8(Medicine)]TJ
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[(University)-323.3(of)-330.3(Berge)14.8(n)]TJ
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[(N-5021)-324.4(Berge)14.8(n)]TJ
T*
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[(Fax:)-325.1(47)-330.1(55975149)]TJ
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[(Keywords)11.5(:)-334.6(Breathlessne)10.1(ss)]TJ
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[(community)-319.7(survey)]TJ
T*
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[(single-bre)9.6(ath)-336.5(transfer)-326.7(factor)-329.5(of)-330.3(the)-329.4(lung)]TJ
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[(Accepted)-325.4(after)-331.6(revision)-329.8(July)-329.5(1)37.7(1)-303.8(1999)]TJ
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[(L,)21.9(CO)]TJ
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[(es)19.6(pe)15.1(ci)18.5(al)18.5(ly)-368.1(em)17.7(ph)21.2(ys)14.4(em)17.7(a)-371.1([)0(1)13.9(])0(,)-378.3(a)-6.9(nd)-382.8(various)-386.5(types)-389.1(of)-373(fibrosis)]TJ
T*
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T*
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T*
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T*
[(forme)-10.6(d)-495.8([5,)-504.3(6].)]TJ
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6.5043 0 TD
(T)Tj
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(L,CO)Tj
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[(allow)-513.7(e)-6.9(arly)-513.9(detection)-516(of)-503.9(funct)-8.2(ional)-515.4(impairment)-524.2(of)-509.6(the)]TJ
T*
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T*
[(ing)-385.9(the)-386.3(relationsh)-12.7(ip)-379.5(betw)-9.8(een)]TJ
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(T)Tj
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(L,CO)Tj
9.963 0 0 9.963 204.888 248.939 Tm
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[(and)-384(the)-386.3(presen)-8.2(ce)-383.6(of)]TJ
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[(respirato)-11.1(ry)-447(symp)-7.4(tom)-7.8(s.)-446.2(In)-447(a)-450.7(cross-sect)-12.3(ional)-452.8(survey)-451.6(of)-452.7(a)]TJ
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T*
[(smok)-7.4(ers)-272.9(and)-270.2(nonsmo)-8.9(kers)-268(ag)-7.6(ed)-269.4(20\26164)-271.3(yrs,)-272.9(V)]TJ
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(IEGI)Tj
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9.963 0 0 9.963 251.376 217.417 Tm
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[(et)-271.8(al.)]TJ
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2.2705 0 TD
([9])Tj
-21.6525 -1.0527 TD
[(observ)-7.8(ed)-434.4(that)-440.7(the)]TJ
/F3 1 Tf
7.5855 0 TD
(T)Tj
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(L,CO)Tj
9.963 0 0 9.963 161.518 206.929 Tm
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[(was)-434.6(signi)-9.8(ficantly)-442.4(different)-438.3(be-)]TJ
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[(tween)-403.6(subje)-7.8(cts)-398.9(with)-398.7(and)-401(without)-403.4(respi)-9.4(ratory)-403.2(symptom)-9.5(s.)]TJ
T*
[(T)63.4(o)-251.2(the)-255.5(author)-9(s)]TJ
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5.6792 0 TD
(')Tj
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[(know)-7(ledge,)-252.1(no)-251.9(da)-7.6(ta)-249(on)-251.9(the)-255.5(associati)-11.9(on)-251.9(be-)]TJ
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(tween)Tj
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2.7656 0 TD
(T)Tj
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7.97 0 0 7.97 91.332 175.465 Tm
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(L,CO)Tj
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[(have)-339.6(been)-333.9(publi)-8.6(shed)-334.7(for)-341.2(Northern)-340.4(Europe.)]TJ
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[(Th)17.1(e)-325.5(h)0(y)21.2(p)0(o)15.5(t)0(h)18.8(e)0(s)13.9(i)0(s)-312.4(o)0(f)-316.1(t)0(h)18.9(e)-325.5(pr)14(es)19.6(en)15.1(t)-321.8(a)0(n)15.1(a)0(l)18.4(y)0(s)20(i)0(s)-318.1(o)0(f)-316.1(a)-325.5(No)17.3(rw)15.7(eg)20.8(ia)12.8(n)]TJ
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T*
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12.5021 0 TD
(T)Tj
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7.97 0 0 7.97 188.22 133.512 Tm
0.0001 Tc
[(L,)21.9(CO)]TJ
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[(.F)197.3(u)213.6(r)197.3(t)214.6(h)197.3(e)212.4(r)197.3(m)213.8(o)197.3(r)216.9(e)197.3(,i)197.3(t)3.2(w)197.3(a)214.2(s)]TJ
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0 Tc
[(al)18.4(so)-287.2(of)-282(in)18.9(te)12.8(re)19.2(st)-283.9(to)-282.7(as)13.9(se)19.6(ss)-282.7(ho)15.5(w)-294.9(t)0(h)18.9(i)0(s)-283.9(r)0(e)19.2(l)0(a)12.8(t)0(i)16.5(o)0(n)21.2(s)0(h)14.4(i)13.9(p)-296.7(v)0(a)20.8(r)0(i)17.3(e)0(d)-286.5(w)0(i)14.9(t)0(h)]TJ
T*
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/F5 1 Tf
31.8898 26.3302 TD
[(Subjects)-344.7(and)-336.5(methods)]TJ
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-6.6921 -2.0998 TD
[(Study)-342.3(popula)-7(tion)]TJ
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[(out)-260.7(shoes)-262.7(and)-264.5(with)-262.1(empt)-9(y)-256.8(trouser)-268.6(pocket)-7.8(s.)-258.4(Before)-263.7(the)-261.2(test)]TJ
0 -1.0471 TD
[(was)-485.8(perfor)-9.8(med,)-484.2(each)-488(subject)-484.4(was)-485.8(inst)-9(ructed)-487.4(in)-481.9(all)-485.5(the)]TJ
25.1977 44.0733 TD
[(requi)-8.2(red)-271.7(manoe)-7.8(uvres.)-269.1(A)-272.2(poster)-271.9(showing)-274.6(the)-266.8(different)-267.6(res-)]TJ
0 -1.0471 TD
[(pirat)-10.6(ory)-339.6(phases)-337.8(was)-343.6(placed)-343.9(in)-339.6(front)-339.4(of)-338.9(the)-340.8(subject.)-342.5(After)]TJ
0 -1.0528 TD
[(the)-420.5(subject)-416.1(had)-418.1(adapted)-418.7(to)-413.6(the)-414.8(mout)-8.6(hpiece,)]TJ
/F11 1 Tf
18.3008 0 TD
($)Tj
/F8 1 Tf
0.8308 0 TD
[(4\261)-7.2(5)-410.5(tidal)]TJ
-19.1316 -1.0471 TD
[(volum)-9.3(es)-407.2(were)-407.7(record)-8.6(ed)-400.3(in)-407.9(order)-405.8(to)-407.9(deter)-8.6(mine)-407.3(a)-405.2(regular)]TJ
0 -1.0528 TD
[(end)-8.4(-expirator)-12.3(y)-279.6(baseline.)-286.8(The)-280(subje)-7.8(ct)-277.5(was)-286.7(asked)-284.7(to)-277.1(exhale)]TJ
0 -1.0471 TD
[(as)-333.2(far)-330.2(as)-327.5(possi)-8.6(ble,)-329.8(until)-329.6(the)-329.4(p)-6.5(oint)-326.5(that)-332.6(it)-330.7(was)-332.2(felt)-328.5(that)-332.6(the)]TJ
0 -1.0528 TD
[(lungs)-263.5(had)-258.8(been)-259.9(c)-6.9(ompletely)-268.3(emptied.)-264.8(Points)-260.1(that)-264.3(were)-259.8(em-)]TJ
0 -1.0471 TD
[(pha)-8.4(sized)-213.1(incl)-8.2(uded)-214(the)-209.9(imp)-7.8(ortan)-8.2(ce)-212.9(of)-213.7(giving)-214.2(a)-211.7(sign)-217.2(when)-212.3(at)]TJ
0 -1.0527 TD
[(maxi)-9(mal)-457.8(exhala)-8.2(tion)-463.1(\(residual)-466.4(volume\),)-462.8(making)-460.1(a)-456.4(rapid)]TJ
T*
[(maxi)-9(mal)-304.1(inhal)-9(ation)-304.9(wi)-7.8(thin)-303.7(2\2612.5)-305(s)-303.6(t)0(o)-305.5(vita)-8.2(l)-299.1(c)0(a)-8(pacity)58.1(,)-302(con-)]TJ
0 -1.0471 TD
[(tinu)-7.8(ing)-232.3(to)-231.5(hold)-233.1(the)-232.7(breat)-8.6(h)-228.4(for)-233.1(10)-229.2(s)-229.6(whi)-8.6(le)-231.9(relaxing)-235.2(agains)-9(t)-230.8(a)]TJ
0 -1.0528 TD
[(close)-8.2(d)-228.4(glot)-7.8(tis)-230.2(\(assi)-10.6(sted)-229(by)-234.8(the)-232.7(valve)-234.6(system\),)-237.5(and)-230.3(e)-6.9(xhaling)]TJ
0 -1.0471 TD
[(rapid)-8.2(ly)-248.6([14,)-249(1)-6.5(6].)-248.2(The)-251.5(test)-248.4(was)-252.5(perfor)-9.8(med)-250.5(on)-246.2(the)-255.5(subject)-251.1(in)]TJ
0 -1.0527 TD
[(a)-348.3(sit)-8.2(ting)-349.3(posit)-9.8(ion)-346.1(wear)-9.4(ing)-351.8(a)-348.3(nose)-351.8(clip.)-350(Eac)-7.2(h)-347.9(subject)-353.5(per-)]TJ
0 -1.0471 TD
[(form)-9.4(ed)-297.8(up)-303.1(to)-299.8(four)-302.2(meas)-8.2(urem)-8.2(ents)-302.9(in)-299.8(order)-303.3(to)-305.5(provide)-305.6(two)]TJ
0 -1.0527 TD
[(error-free)-268.8(tests.)-267.8(A)-266.5(minim)-9.2(um)-266.4(interval)-271.7(of)-264.9(4)-262.5(min)-269.6(was)-269.6(requir-)]TJ
0 -1.0471 TD
[(ed)-377.5(betw)-9.8(een)-378.7(each)-379.8(test.)-379.7(The)-376.7(met)-8.2(hod)-377.9(of)-378.7(J)]TJ
6.974 0 0 6.974 469.247 604.29 Tm
0.0001 Tc
(ONES)Tj
9.963 0 0 9.963 491.074 604.29 Tm
0 Tc
[(and)-378.3(M)]TJ
6.974 0 0 6.974 518.003 604.29 Tm
0.0001 Tc
(EADE)Tj
9.963 0 0 9.963 309.316 593.801 Tm
0 Tc
[([17])-262.3(for)-261.6(determin)-10.7(ing)-255.1(breat)-8.6(h-hol)-7.8(ding)-255.8(time)-261.7(was)-258.2(used)-260.7(in)-260(this)]TJ
T*
[(study)55.2(.)]TJ
1.0015 -1.0527 TD
[(Of)-359.9(th)13.2(e)-365.4(1)0(,)21.6(2)0(7)15.5(5)-365(su)14.4(bj)18.9(ec)20.4(ts)-357.9(wh)17.3(o)-370.7(u)0(n)21.2(d)0(e)15.1(r)0(w)15.7(e)0(n)20.8(t)]TJ
/F3 1 Tf
15.575 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 479.905 572.882 Tm
0.0001 Tc
[(L,)21.9(CO)]TJ
9.963 0 0 9.963 501.109 572.882 Tm
0 Tc
[(me)17.7(as)14(ur)19.6(e-)]TJ
-19.2511 -1.0471 TD
[(me)12(nt)18.9(s,)-264.1(da)15.1(ta)-266.1(fr)18(om)-266.4(15)15.5(4)-273.9(w)0(e)16.9(r)0(e)-265.3(e)0(x)15.1(c)0(l)18.5(u)0(d)21.2(e)0(d)-269.4(f)0(r)18(o)0(m)-266.4(f)0(u)13.9(r)0(t)17.3(h)0(e)20.8(r)-275.5(an)15.1(al)18.5(ys)20(is)]TJ
0 -1.0528 TD
[(fo)13.9(r)-286.9(t)0(h)18.9(e)-291.4(fo)19.6(ll)16.5(ow)17.3(in)18.8(g)-291(r)0(e)19.2(a)0(s)13.9(o)0(n)21.2(s)0(:)-278.2(a)-291.4(le)18.4(ak)-280.8(in)-277.1(th)18.9(e)-291.4(s)0(a)19.6(m)0(p)18.1(l)0(e)-283.1(b)0(a)20.8(g)-291(oc)20.8(cu)15.1(r)20.4(-)]TJ
0 -1.0471 TD
[(ri)17.3(ng)-234.8(du)15.5(ri)17.3(ng)-234.8(th)18.8(e)-240.2(f)0(i)11.6(r)0(s)18.4(t)-242.1(18)-234.8(da)20.8(ys)-236(of)-236.4(th)18.8(e)-240.2(s)0(t)17.7(u)0(d)15.5(y)-245.5(\(n)]TJ
/F10 1 Tf
16.7416 0 TD
(=)Tj
/F8 1 Tf
0.5406 0 TD
[(10)15.5(8\))19.6(;)-247.8(i)13.9(na)15.1(bi)18.9(li)16.5(ty)]TJ
-17.2822 -1.0527 TD
[(to)-248.6(ho)15.5(ld)-242.9(br)14(ea)20.4(th)-248.6(fo)19.6(r)-258.4(1)0(0)-246.2(s)-252.3(in)-248.6(at)-249(le)18.4(as)19.6(t)-259.2(t)0(w)14.9(o)]TJ
/F3 1 Tf
14.6816 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 461.027 531.042 Tm
0.0001 Tc
[(L,)21.9(CO)]TJ
9.963 0 0 9.963 481.096 531.042 Tm
0 Tc
[(me)12(as)19.6(ur)19.6(em)12(en)20.8(ts)]TJ
-17.2424 -1.0471 TD
(\(n)Tj
/F10 1 Tf
0.8081 0 TD
(=)Tj
/F8 1 Tf
0.5406 0 TD
[(16)15.5(\),)-384(no)15.5(t)-390.1(f)0(u)13.9(l)0(f)17.3(i)0(l)16.5(l)0(i)22.2(n)0(g)-388.5(t)0(h)18.8(e)-393.8(re)13.5(pr)19.6(od)15.5(uc)20.8(ib)18.8(il)16.5(it)16.5(y)-393.4(c)0(r)19.2(i)0(t)16.5(e)0(r)13.5(i)0(o)18.8(n)-393.4(of)-384.4(tw)14.9(o)]TJ
-1.3487 -1.0528 TD
[(te)12.8(st)17.7(s)-349.1(b)0(e)15.1(i)0(n)18.8(g)-353.6(wi)14.9(t)13.9(h)0(i)13.2(n)-347.9(10)15.5(%)-355.9(o)0(f)-344.6(e)0(a)20.4(c)0(h)-343.4(o)0(t)18.9(h)0(e)15.1(r)-355.2(\(n)]TJ
/F10 1 Tf
16.0417 0 TD
(=)Tj
/F8 1 Tf
0.5406 0 TD
[(25)15.5(\);)-341.3(an)15.1(d)-353.6(u)0(n)21.2(d)0(e)15.1(r)20.4(-)]TJ
-16.5823 -1.0471 TD
[(go)15.5(in)18.9(g)-251.2(u)0(n)15.5(s)0(a)19.6(t)0(i)16.5(s)0(f)18.4(a)0(c)14.7(t)0(o)18.8(r)0(y)-247.8(s)0(p)20(i)0(r)17.3(o)0(m)18.1(e)0(t)18.4(r)0(i)11.6(c)-251.6(me)17.7(as)19.6(ur)13.9(em)17.7(en)15.1(ts)-244.1(\(n)]TJ
/F10 1 Tf
19.4275 0 TD
(=)Tj
/F8 1 Tf
0.5406 0 TD
[(5\))13.9(.)-250.8(T)0(h)17.1(e)]TJ
-19.9681 -1.0527 TD
[(re)13.5(fe)19.2(re)13.5(nc)20.8(e)-314.2(e)0(q)20.8(u)0(a)15.1(t)0(i)16.5(o)0(n)21.2(s)-314.9(fo)19.6(r)]TJ
/F3 1 Tf
9.3723 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 408.132 489.203 Tm
0.0001 Tc
[(L,)21.9(CO)]TJ
9.963 0 0 9.963 428.825 489.203 Tm
0 Tc
[(\(i)17.3(n)-308.1(m)0(m)14.9(o)0(l)]TJ
/F7 1 Tf
3.659 0.1992 TD
(.)Tj
/F8 1 Tf
0.2731 -0.1992 TD
[(mi)15.7(n)]TJ
7.472 0 0 6.641 483.08 493.625 Tm
(-1)Tj
/F7 1 Tf
9.963 0 0 9.963 489.033 491.187 Tm
(.)Tj
/F8 1 Tf
0.2732 -0.1992 TD
[(kP)16.3(a)]TJ
7.472 0 0 6.641 506.324 493.625 Tm
(-1)Tj
9.963 0 0 9.963 512.277 489.203 Tm
0.3097 Tc
[(\)u)309.7(s)324(e)309.7(d)]TJ
-20.3722 -1.0471 TD
0 Tc
[(in)-379.5(th)18.9(is)-375(an)15.1(al)18.5(ys)20(is)-380.7(w)12.4(e)0(r)13.5(e)-382.4(de)15.1(ri)17.3(ve)20.8(d)-387.7(f)0(r)18(o)0(m)-380.3(a)-382.4(se)19.6(gm)12.4(en)20.8(t)-384.4(o)0(f)-378.7(h)0(e)15.1(a)0(l)18.5(t)0(h)18.8(y)]TJ
0 -1.0528 TD
[(su)14.4(bj)18.9(ec)14.7(t)13.9(s)-371.8(w)12.4(h)0(o)-360(h)0(a)20.8(d)-370.7(ne)20.8(ve)15.1(r)-366.6(s)0(m)16.9(o)0(k)21.2(e)0(d)15.1(,)-364.6(ta)18.5(ke)15.1(n)-365(f)0(r)18(o)0(m)-363.2(a)-365.4(ra)19.2(nd)15.5(om)18.1(ly)]TJ
0 -1.0471 TD
[(se)13.9(le)18.4(ct)18.4(ed)-332(po)21.2(pu)15.5(la)18.4(ti)16.5(on)-325.9(fr)12.4(om)-329(th)18.9(e)-336.9(s)0(o)20(u)0(t)13.2(h)0(-)19.6(w)0(e)16.9(s)0(t)17.7(e)0(r)13.5(n)-336.5(co)20.8(as)13.9(t)-338.9(o)0(f)-327.5(N)0(o)17.3(r)20.4(-)]TJ
0 -1.0528 TD
[(wa)16.9(y)67.5(,)-455.6(an)20.8(d)-456(w)0(e)16.9(r)0(e)-447.4(a)0(s)-447(f)0(o)19.6(l)0(l)16.5(o)0(w)17.3(s)-457.2([1)19.6(4]:)]TJ
/F3 1 Tf
13.4866 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 449.178 447.364 Tm
0.0001 Tc
(L,CO)Tj
9.963 0 0 9.963 471.628 447.364 Tm
0 Tc
[(\(females)-11.5(\))]TJ
/F10 1 Tf
3.7102 0 TD
(=)Tj
/F8 1 Tf
0.7227 0 TD
(-4.93)Tj
-20.725 -1.0471 TD
[(+9.)-8.2(1)33.4(1)]TJ
/F10 1 Tf
2.2876 0 TD
(=)Tj
/F8 1 Tf
0.552 0 TD
[(height)-527.6(\(in)-518.4(m\))-518.4(-)-520.2(0.043)-521.3(age)-520.9(\(in)-518.4(yrs\);)-522.7(and)]TJ
/F3 1 Tf
17.6236 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 518.683 436.932 Tm
0.0001 Tc
(L,CO)Tj
9.963 0 0 9.963 309.316 426.444 Tm
0 Tc
[(\(mal)-10.6(es\))]TJ
/F10 1 Tf
2.9534 0 TD
(=)Tj
/F8 1 Tf
0.7227 0 TD
[(-8.05+1)-7.1(2.17)-338.4(height)-339.8(\(in)-336.3(m\))-336.3(-0.057)-335.8(age)-338.8(\(in)-336.3(yrs\).)]TJ
-2.6746 -1.0471 TD
[(Sp)16.3(ir)17.3(om)18.1(et)12.8(ry)-355.9(wa)16.9(s)-366.2(a)0(l)18.5(s)0(o)-361.2(p)0(e)20.8(r)0(f)18(o)0(r)13.9(m)0(e)17.7(d)-365(us)14.3(in)18.9(g)-365(t)0(h)18.8(e)-371.1(G)12.4(o)0(u)15.5(l)0(d)-356.7(2)0(1)15.5(0)0(0)]TJ
-1.0015 -1.0527 TD
[(sp)14.4(ir)17.3(om)18.1(et)18.5(er)70.4(.)-222.3(T)12.2(he)-212.5(in)18.8(sp)20(ir)11.6(at)18.5(or)19.6(y)-217(a)0(n)15.1(d)-217(ex)15.1(pi)18.9(ra)19.2(to)13.2(ry)-208(li)16.5(mb)18.1(s)-218.2(o)0(f)-208(t)0(h)13.2(e)-217.4(sp)20(i-)]TJ
0 -1.0471 TD
[(ro)13.9(me)17.7(te)18.4(r)-269.8(w)0(e)11.2(r)0(e)-259.6(c)0(a)14.7(l)13.9(ib)13.2(ra)19.2(te)18.4(d)-273.9(a)0(u)20.8(t)0(o)18.9(m)0(a)12(t)0(i)16.5(c)0(a)20.4(l)0(l)16.5(y)-268.2(wi)14.9(th)-260(a)-274.3(2)0(.)21.6(1)0(-)14(L)-266.7(mo)12.4(to)18.9(r)20.4(-)]TJ
0 -1.0528 TD
[(dr)13.9(iv)18.9(en)-605.1(sy)14.4(ri)17.3(ng)21.2(e)-615.7(b)0(e)15.1(f)0(o)19.6(r)0(e)-606.7(e)0(a)14.7(c)0(h)-605.1(e)0(x)20.8(a)0(m)12(i)0(n)18.8(a)0(t)18.5(i)0(o)18.9(n)0(.)-604.3(T)0(h)17.1(e)-615.7(vo)15.5(lu)18.9(me)]TJ
0 -1.0471 TD
[(ca)14.7(li)16.5(br)19.6(at)18.5(io)13.2(n)-256.8(w)0(a)11.2(s)-258(ve)15.1(ri)17.3(fi)17.3(ed)-252.3(ea)14.7(ch)-252.3(da)20.8(y)-262.5(w)0(i)14.9(t)0(h)-254.3(a)-262.9(3-)19.6(L)-261(G)0(o)17.3(u)0(l)13.2(d)-256.8(Mo)13.6(de)20.8(l)]TJ
0 -1.0528 TD
[(M-)12(20)-291.7(ca)14.7(li)22.2(br)13.9(at)18.4(in)18.8(g)-302.4(s)0(y)14.4(r)0(i)17.3(n)0(g)21.2(e)-308.5(\(S)20.4(en)15.1(so)20(r)-304(M)0(e)18.9(d)0(i)13.2(c)0(s)19.6(\))0(,)-293(w)0(i)14.9(t)0(h)-294.1(e)0(m)17.7(p)0(t)13.2(y)0(i)18.9(n)0(g)]TJ
0 -1.0471 TD
[(ti)16.5(me)12(s)-440.1(r)0(a)19.2(n)0(g)15.5(i)0(n)18.9(g)-444.6(0.)15.9(5\261)21.2(6)-444.6(s)-440.1([1)13.9(4].)-441.7(The)-456.4(varia)-8.6(bles)-456.6(record)-8.6(ed)-451.5(in-)]TJ
0 -1.0527 TD
[(cluded)-286.6(forced)-287.4(vital)-284.5(capaci)-8.6(ty)-277.1(\(FVC\))-288(and)-281.5(forced)-287.4(expiratory)]TJ
T*
[(volum)-9.3(e)-251.6(i)0(n)-248.6(one)-253.1(second)-251.3(\(FE)-7.2(V)]TJ
7.97 0 0 7.97 420.491 332.277 Tm
(1)Tj
9.963 0 0 9.963 424.46 332.277 Tm
[(\).)-253.1(Three)-255(technicall)-13.1(y)-245.5(satisfac-)]TJ
-11.5575 -1.0471 TD
[(tory)-473.7(measurem)-10.7(ents)-468(wer)-8.2(e)-462.1(obtai)-9(ned,)-469.7(in)-464.8(which)-471.5(FVC)-471.1(was)]TJ
0 -1.0527 TD
[(reprod)-8.2(ucibl)-9(e)-416.6(w)0(i)-7.8(thin)-423.2(300)-417.7(mL.)-424.6(A)-420.1(technicall)-13.1(y)-416.2(sati)-9.4(sfactory)]TJ
0 -1.0471 TD
[(test)-271.2(met)-275.7(the)-266.8(lung)-272.9(function)-274.6(testing)-275.8(criteria)-273.7(of)-270.6(the)-272.5(European)]TJ
0 -1.0527 TD
[(Coa)-7.4(l)-333.2(and)-338.4(Steel)-338.6(Comm)-8.4(unity)-338.6([18].)]TJ
1.0015 -1.0471 TD
[(A)-283.5(v)0(e)20.8(n)0(o)15.5(u)0(s)-344.2(b)0(l)18.9(o)0(o)15.5(d)-347.9(sa)14(mp)18.1(le)-345.7(w)12.4(a)0(s)-344.6(d)0(r)14(a)0(w)16.9(n)-347.9(be)15.1(fo)19.6(re)-345(th)18.8(e)-354(t)0(r)17.3(a)0(n)15.1(s)0(f)18.4(e)0(r)]TJ
-1.0015 -1.0527 TD
[(te)12.8(st)-551.4(fo)19.6(r)-565.7(d)0(e)20.8(t)0(e)18.4(r)0(m)16.5(i)0(n)13.2(a)0(t)18.5(i)0(o)18.9(n)-564.1(of)-549.4(to)18.9(ta)12.8(l)-560.8(h)0(a)20.8(e)0(m)12(o)0(g)21.2(l)0(o)18.9(b)0(i)13.2(n)-558.4(an)15.1(d)-558.4(c)0(a)14.7(r)0(b)19.6(-)]TJ
0 -1.0471 TD
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9.963 0 0 9.963 112.479 311.301 Tm
0 Tc
[(than)-370(subje)-7.8(cts)-370.5(without)-374.9(\(table)-370.2(3\).)-367.7(Exc)-6.8(ept)-369.3(for)]TJ
-5.4402 -1.0527 TD
[(breat)-8.6(hlessness,)-345.2(the)-335.1(magni)-9.7(tude)-335.9(of)-338.9(the)-340.8(dif)10.8(ference)-345.9(in)]TJ
/F3 1 Tf
20.4575 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 267.647 300.813 Tm
(L,CO)Tj
9.963 0 0 9.963 58.28 290.381 Tm
[(between)-251.9(those)-246.8(with)-245.1(and)-241.7(wi)-7.8(thout)-241.9(eac)-9.2(h)-239.8(symp)-7.4(tom)-241.1(ranged)-251.7(6\261)]TJ
0 -1.0528 TD
[(13%)-289.2(in)-282.7(both)-284.3(sexes,)-291.9(being)-285.4(highes)-8.6(t)-282(for)-290(morning)-291.3(cough)-288.7(and)]TJ
0 -1.0471 TD
[(chroni)-9(c)-336.9(cough,)-346(and)-338.4(lowest)-344.9(for)-341.2(whee)-7.8(zing.)-342(The)-342.6(difference)]TJ
0 -1.0527 TD
[(in)-390.9(mean)]TJ
/F3 1 Tf
3.6932 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 100.63 258.973 Tm
0.0001 Tc
(L,CO)Tj
9.963 0 0 9.963 122.287 258.973 Tm
0 Tc
[(between)-394.1(those)-389.1(wi)-7.8(th)-385.2(and)-389.7(wi)-7.8(thout)-389.8(breat)-8.6(h-)]TJ
-6.4246 -1.0471 TD
[(lessne)-10.1(ss)-419.3(grade)-421.6(2)-416.2(and)-418.1(breat)-8.6(hless)-9(ness)-421.2(grade)-421.6(3)-416.2(was)-423.2(much)]TJ
0 -1.0528 TD
[(higher)-225.2(in)-214.5(male)-9.4(s)-212.5(\(resp)-8.6(ectively)-225(21)-217.8(and)-218.9(47%\))-217.6(than)-222.1(in)-214.5(fema)-8.6(les)]TJ
T*
[(\(resp)-8.6(ectively)-515.2(13)-508(and)-503.5(1)-6.5(5%\).)-507.4(When)-511.1(compa)-7.8(ring)-507.8(subje)-7.8(cts)]TJ
0 -1.0471 TD
[(with)-575.1(and)-577.4(without)-574.1(b)-6.5(ronchial)-576.6(asthma)-12.1(,)-569.4(n)0(o)-570.6(difference)-574.1(in)]TJ
/F3 1 Tf
0 -1.0527 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 63.78 206.646 Tm
0.0001 Tc
(L,CO)Tj
9.963 0 0 9.963 84.699 206.646 Tm
0 Tc
[(was)-309.4(o)-6.5(bserved,)-316.6(in)-311.2(either)-319(males)-312.9(o)-6.5(r)-309.7(females.)-316.8(Pa)-6.8(tients)]TJ
-2.6518 -1.0471 TD
[(suffering)-277.4(from)-282.5(COLD)-281.5(had)-281.5(signifi)-9.6(cantly)-283.3(lower)-279.6(unadju)-7.4(sted)]TJ
/F3 1 Tf
0 -1.0527 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 63.78 185.726 Tm
0.0001 Tc
(L,CO)Tj
9.963 0 0 9.963 85.55 185.726 Tm
0 Tc
[(than)-398.5(those)-400.4(without)-403.4(COLD)-401(\(table)-404.4(3\),)-396.2(and)-395.3(a)-399.5(mean)]TJ
-2.7372 -1.0471 TD
[(20%)-260.7(pred)-261.1(fall)-260.2(in)]TJ
/F3 1 Tf
6.6921 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 130.45 175.294 Tm
0.0001 Tc
(L,CO)Tj
9.963 0 0 9.963 150.86 175.294 Tm
0 Tc
[(was)-258.2(noted)-262.7(in)-260(males)]TJ
/F3 1 Tf
7.8586 0 TD
(versus)Tj
/F8 1 Tf
2.7941 0 TD
[(12%)-260.7(in)]TJ
-19.9454 -1.0528 TD
[(fema)-8.6(les.)]TJ
1.0015 -1.0471 TD
[(In)-287.7(ma)12(le)18.4(s,)-286.9(th)13.2(e)]TJ
/F3 1 Tf
5.406 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 127.502 154.375 Tm
0.0001 Tc
[(L,)21.9(CO)]TJ
9.963 0 0 9.963 148.082 154.375 Tm
0 Tc
[(\(i)17.3(n)-296.7(%)-299(pr)13.9(ed)20.8(\))-298.3(d)0(e)15.1(c)0(r)19.2(e)0(a)14.7(s)0(e)19.6(d)-296.7(si)17.7(gn)15.5(if)17.3(ic)18.4(an)15.1(tl)16.5(y)]TJ
-9.0138 -1.0528 TD
[(wi)14.9(th)-481.9(i)13.9(n)0(c)15.1(r)0(e)19.2(a)0(s)14(i)0(n)18.9(g)-490.2(br)19.6(ea)14.7(th)18.9(le)18.4(ss)18.9(ne)15.1(ss)-481.9(sc)19.6(or)19.6(e)-490.6(\()0(p)]TJ
/F10 1 Tf
16.0587 0 TD
(<)Tj
/F8 1 Tf
0.5406 0 TD
[(0.)15.9(00)21.2(1\))-481.1(\(f)18(ig)13.2(.)-484.1(1\),)]TJ
-16.5993 -1.0471 TD
[(where)-10.1(as)-333.2(in)-334(fema)-8.6(les)-336.3(no)-331.6(such)-340.4(trend)-338.2(was)-337.9(observ)-7.8(ed.)]TJ
1.0015 -1.0528 TD
-0.0179 Tc
[(I)-17.9(n)-294.2(a)-303.6(m)-17.9(ul)-17.9(ti)-17.9(pl)-17.9(e)-295.4(l)-17.9(in)-17.9(ea)-17.9(r)-294.6(r)-17.9(eg)-17.9(re)-17.9(ss)-17.9(io)-17.9(n)-292.6(a)-17.9(na)-17.9(ly)-17.9(si)-17.9(s)-296.1(o)-17.9(f)]TJ
/F3 1 Tf
16.5766 0 TD
0 Tc
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 238.79 122.967 Tm
0.0001 Tc
[(L,)21.9(CO)]TJ
9.963 0 0 9.963 259.2 122.967 Tm
0 Tc
[(ad)15.1(ju)18.8(st)17.7(-)]TJ
-20.1673 -1.0471 TD
[(in)18.9(g)-296.7(f)0(o)19.6(r)-298.3(se)19.6(x,)-285.7(ag)15.1(e)-297.1(a)0(n)20.8(d)-296.7(he)20.8(ig)13.2(ht)-282.7(as)-287.7(we)16.9(ll)-290.8(as)-282(sm)16.9(ok)15.5(in)18.9(g)-296.7(h)0(a)20.8(b)0(i)13.2(t)0(s)17.7(,)-290.6(th)13.2(e)]TJ
25.1977 26.5749 TD
[(sy)14.4(mp)18.1(to)18.8(ms)-307.5(co)20.8(ug)15.5(h)-308.1(i)0(n)-305.5(t)0(h)18.9(e)-314.2(mo)18.1(rn)19.6(in)13.2(g)-308.1(a)0(n)15.1(d)-308.1(ch)15.1(ro)19.6(ni)13.2(c)-308.5(c)0(o)15.1(u)0(g)21.2(h)-313.8(we)16.9(re)]TJ
0 -1.0641 TD
[(st)17.7(il)16.5(l)-264.9(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(t)0(l)16.5(y)-256.8(as)13.9(so)20(ci)18.4(at)18.4(ed)-252.3(wi)14.9(th)-254.3(a)-257.2(r)0(e)19.2(d)0(u)15.5(c)0(e)14.7(d)]TJ
/F3 1 Tf
17.0489 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 484.611 366.69 Tm
0.0001 Tc
[(L,)21.9(CO)]TJ
9.963 0 0 9.963 504.737 366.69 Tm
0 Tc
[(wh)17.3(er)13.5(ea)20.4(s)]TJ
-19.6153 -1.0641 TD
[(ph)15.5(le)18.4(gm)-255.1(wh)11.6(en)-252.3(co)15.1(ug)21.2(hi)13.2(ng)-251.9(an)15.1(d)-262.5(w)0(h)17.3(e)0(e)14.7(z)0(i)18.5(n)0(g)-257.6(w)12.4(er)13.5(e)-262.9(n)0(o)-257.6(l)0(o)18.9(n)0(g)21.2(e)0(r)-259.6(s)0(i)17.7(g)0(-)]TJ
T*
[(ni)13.2(fi)17.3(ca)20.4(nt)18.9(ly)-288.4(as)13.9(so)20(ci)18.4(at)18.4(ed)-292.2(\(t)17.3(ab)20.8(le)-288.8(4\).)-299.4(Breathle)-12.7(ssness)-311.3(was)-309.4(related)]TJ
T*
[(to)-237.2(decreased)]TJ
/F3 1 Tf
5.1386 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 366.009 334.885 Tm
0.0001 Tc
(L,CO)Tj
9.963 0 0 9.963 386.135 334.885 Tm
0 Tc
[(after)-232.1(adjus)-7.8(ting)-235.4(for)-233.1(sex,)-231.9(a)-6.9(ge,)-229.9(height)-237.4(and)]TJ
-7.7107 -1.0641 TD
[(smok)-7.4(ing)-442.8(habits,)-443.8(and)-446.6(a)-439.4(greater)-444.6(reduct)-9.4(ion)-442.8(in)]TJ
/F3 1 Tf
18.261 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 496.743 324.283 Tm
0.0001 Tc
(L,CO)Tj
9.963 0 0 9.963 518.91 324.283 Tm
0 Tc
(with)Tj
-21.038 -1.0641 TD
[(incre)-8.6(asing)-337.8(breathless)-11.9(ness)-335.9(score)-337.5(was)-332.2(found)-335.5(in)-334(males)-335.7(than)]TJ
T*
[(in)-328.3(fema)-8.6(les)-324.9(\(the)-331.8(regres)-9.8(sion)-325.3(coefficient)-327.6(in)-328.3(males)-330(being)-331(ap-)]TJ
T*
[(proxi)-7.8(mate)-9.4(ly)-260(five)-263.5(time)-11.4(s)-258(that)-264.3(in)-265.7(females\))-273.3(\(table)-267.8(4\).)-259.6(Thi)-8.8(s)-258(an-)]TJ
T*
[(alysi)-10.2(s)-320.6(was)-326.5(then)-324.5(repeat)-9.8(ed)-320.6(ex)-7.6(cluding)-329.2(subjects)-327(with)-330.4(asthma)]TJ
T*
[(and)-486.4(COLD)-8.4(:)-481.2(the)-483.1(breathless)-11.9(ness)-483.8(score)-485.4(remained)-486.8(signi)-9.8(fi-)]TJ
T*
[(can)-8.8(tly)-234.7(associated)-244(wi)-7.8(th)]TJ
/F3 1 Tf
8.9569 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 404.05 260.674 Tm
(L,CO)Tj
9.963 0 0 9.963 424.176 260.674 Tm
[(in)-237.2(mal)-8.2(es)-236.4(\(p)]TJ
/F10 1 Tf
4.3703 0 TD
(<)Tj
/F8 1 Tf
0.5577 0 TD
[(0.01\),)-238.7(but)-238(not)-232.3(in)]TJ
-16.4571 -1.0641 TD
[(fema)-8.6(les)-336.3(\(p)]TJ
/F10 1 Tf
4.2281 0 TD
(=)Tj
/F8 1 Tf
0.552 0 TD
(0.80\).)Tj
-3.7785 -1.0527 TD
[(Ad)11.6(di)18.8(ti)16.5(on)21.2(al)-243.3(mu)12.4(lt)22.2(ip)13.2(le)-243.3(li)16.5(ne)20.8(ar)-248.2(re)19.2(gr)19.6(es)14(si)17.7(on)-240.5(an)15.1(al)18.4(ys)14.4(es)-242.1(we)16.9(re)-242.5(pe)15.1(r)20.4(-)]TJ
-1.0015 -1.0641 TD
[(fo)13.9(rm)16.5(ed)-326.3(in)18.8(cl)18.5(ud)15.5(in)18.8(g)-330.8(a)0(l)18.5(l)-338.9(th)18.9(e)-331.2(r)0(e)13.5(s)0(p)20(i)0(r)17.3(a)0(t)18.4(o)0(r)14(y)-330.8(sy)20(mp)12.4(to)18.8(ms)-324.5(as)-327.5(we)16.9(ll)-325(as)]TJ
T*
[(se)13.9(x,)-211.7(ag)15.1(e,)-212.1(he)20.8(ig)13.2(ht)18.9(,)-222.3(s)0(m)16.9(o)0(k)15.5(i)13.9(ng)-217.8(ha)20.8(bi)18.9(ts)12(,)-222.3(s)0(m)16.9(o)0(k)21.2(i)0(n)18.9(g)-222.7(co)15.1(ns)20(um)12.4(pt)18.9(io)18.8(n)-222.7(\()0(i)17.3(n)]TJ
T*
[(pa)15.1(ck)15.1(-y)19.6(rs)18.4(\))-298.3(a)0(n)20.8(d)-296.7(th)18.8(e)-297.1(c)0(o)15.1(n)0(c)20.8(e)0(n)15.1(t)0(r)17.3(a)0(t)18.4(i)0(o)18.8(n)0(s)-287.2(o)0(f)-287.7(h)0(a)15.1(e)0(m)17.7(o)0(g)15.5(l)0(o)18.9(b)0(i)18.9(n)-296.7(an)15.1(d)-291(c)0(a)14.7(r)20.4(-)]TJ
T*
[(bo)15.5(xy)15.5(ha)20.8(em)17.7(og)15.5(lo)18.9(bi)18.9(n)-376.3(i)0(n)-362.4(t)0(h)13.2(e)-371.1(mo)18.1(de)15.1(l)-373(\()0(t)17.3(a)0(b)15.1(l)0(e)-362.8(5\).)-379.1(Breathl)-11.5(essness)]TJ
T*
[(was)-354.9(the)-346.5(only)-346.9(symp)-7.4(tom)-349.3(that)-349.7(rema)-8.6(ined)-347.3(signi)-9.8(ficantly)-351.4(asso-)]TJ
T*
[(ciat)-8.6(ed)-235.2(wi)-7.8(th)]TJ
/F3 1 Tf
4.598 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 360.624 175.975 Tm
(L,CO)Tj
9.963 0 0 9.963 378.425 175.975 Tm
[(:)-236.5(the)-244.1(higher)-242.3(the)-238.4(breat)-8.6(hless)-9(ness)-239.2(score,)-241.1(the)]TJ
-6.9368 -1.0641 TD
[(low)-8.6(er)-333.6(the)]TJ
/F3 1 Tf
4.1313 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 356.031 165.373 Tm
0.0001 Tc
(L,CO)Tj
9.963 0 0 9.963 373.776 165.373 Tm
0 Tc
(.)Tj
-5.4686 -1.0471 TD
[(Fi)14(rs)18.4(t-)17.3(or)19.6(de)15.1(r)-560(i)0(n)18.9(t)0(e)18.4(r)0(a)13.5(c)0(t)18.4(i)0(o)18.8(n)-558.4(te)18.4(rm)16.5(s)-559.6(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)-558.4(t)13.9(h)0(e)-553.9(r)0(e)19.2(s)0(p)20(i)0(r)17.3(a)0(t)12.8(o)0(r)19.6(y)]TJ
-1.0015 -1.0641 TD
[(sy)14.4(mp)18.1(to)18.8(ms)-375.7(an)15.1(d)-382(s)0(e)19.6(x)0(,)-376.7(a)0(g)20.8(e)-382.4(an)15.1(d)-382(s)0(m)16.9(o)0(k)21.2(i)0(n)13.2(g)-382(ha)20.8(bi)18.9(ts)-375(re)13.5(sp)20(ec)14.7(ti)16.5(ve)20.8(ly)]TJ
T*
[(we)16.9(re)-373.4(th)18.9(en)-371.8(ad)15.1(de)20.8(d)-382(o)0(n)21.2(e)-382.4(at)-374.2(a)-376.7(t)0(i)16.5(m)0(e)-375(t)13.9(o)-382(t)0(h)18.8(e)-382.4(mu)18.1(lt)16.5(ip)18.8(le)-374.2(li)16.5(ne)20.8(ar)-373.4(re)19.2(-)]TJ
T*
[(gr)13.9(es)19.6(si)17.7(on)-223.5(m)13.2(o)0(d)15.5(e)0(l)-220.6(p)0(r)19.6(e)0(s)13.9(e)0(n)20.8(t)0(e)12.8(d)-228.4(in)-220.2(t)13.9(h)0(e)-223.9(u)0(p)21.2(p)0(e)15.1(r)-230(pa)20.8(rt)-221.7(of)-219.4(ta)18.4(bl)13.2(e)-228.8(5)0(.)-228.8(Only)]TJ
T*
[(the)-227(significant)-232.1(and)-218.9(border)-8.2(line)-224.5(signifi)-9.6(cant)-222.5(interaction)-231.3(terms)]TJ
ET
1 i 
309.316 768.302 227.168 -0.51 re
f
309.316 751.861 227.168 -0.51 re
f
309.316 489.316 227.168 -0.454 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 309.316 772.667 Tm
[(Table)-338.2(2.)-330.4(\261)-630.4(Characteristics)-301.7(of)-298.8(the)-296.9(study)-295.8(population)-293.8(by)-301.1(sex)]TJ
/F8 1 Tf
15.371 -1.7135 TD
[(Females)-2965.2(Males)]TJ
-15.371 -1.998 TD
[(Subjects)-335.1(n)-11728.5(43\213545)-2776(41\213576)]TJ
0 -1.0559 TD
[(Age)-336.7(yrs)-13487.4(16)-4810.7(16)]TJ
T*
[(Height)-339.9(cm)-11173.2(165\2136)-3269.7(178\2137)]TJ
T*
[(Hb)-337.4(g)]TJ
/F7 1 Tf
2.0549 0.2213 TD
(.)Tj
/F8 1 Tf
0.2719 -0.2213 TD
(L)Tj
6.725 0 0 5.977 335.565 715.011 Tm
(-1)Tj
8.966 0 0 8.966 445.266 710.986 Tm
[(13.7\2139.4)-2275.9(15.2\2139.8)]TJ
-15.1623 -1.0559 TD
[(HbCO)-338.1(%)-335.1(total)-333.2(Hb)-7766.8(15.4\21312.8)-1775.9(18.3\21315.0)]TJ
/F3 1 Tf
T*
(T)Tj
/F8 1 Tf
7.173 0 0 7.173 314.305 692.05 Tm
(L,CO)Tj
6.725 0 0 5.977 330.35 696.075 Tm
(+)Tj
8.966 0 0 8.966 337.153 692.05 Tm
(mmol)Tj
/F7 1 Tf
2.3079 0.2276 TD
(.)Tj
/F8 1 Tf
0.2719 -0.2276 TD
(min)Tj
6.725 0 0 5.977 374.116 696.075 Tm
(-1)Tj
/F7 1 Tf
8.966 0 0 8.966 379.672 694.091 Tm
(.)Tj
/F8 1 Tf
0.2719 -0.2276 TD
(kPa)Tj
6.725 0 0 5.977 395.433 696.075 Tm
(-1)Tj
8.966 0 0 8.966 445.266 692.05 Tm
[(7.83\2131.6)-2275.9(10.9\2132.4)]TJ
-12.1653 -1.0496 TD
[(%)-335.1(pred)-9502.1(102\21314.6)-2019.6(100\21315.8)]TJ
/F3 1 Tf
-2.9971 -1.0559 TD
(V)Tj
/F8 1 Tf
7.173 0 0 7.173 313.852 673.171 Tm
(A)Tj
8.966 0 0 8.966 322.016 673.171 Tm
[(L)-13142(5.42\2130.76)-1775.9(7.34\2131.03)]TJ
-1.4163 -1.0559 TD
[(Smoking)-334.4(habits)-337.8(%)]TJ
0.6702 -1.0559 TD
[(Nonsmokers)-10998.7(63)-4810.7(46)]TJ
T*
[(Exsmokers)-11612.8(13)-4810.7(23)]TJ
T*
[(Current)-334(smokers)-9365.7(24)-4810.7(31)]TJ
-0.6702 -1.0559 TD
[(Smoking)-334.4(comsumption)-339(pack-yrs)-2591(3.3\2136.7)-2776(8.4\21312.4)]TJ
T*
[(Symptom)-336.3(group)-333.5(%)]TJ
0.6702 -1.0559 TD
[(Asymptomatic)-10188.7(55)-4810.7(55)]TJ
T*
[(Morning)-335.6(cough)-9766.1(19)-4810.7(26)]TJ
T*
[(Phlegm)-334.7(when)-329.8(coughing)-6460.1(15)-4810.7(23)]TJ
T*
[(Chronic)-333.1(cough)-10468(7)-4893.4(1)0(0)]TJ
T*
[(Wheezing)-11997.8(26)-4810.7(27)]TJ
T*
[(Breathlessness)-335.9(grade)-333.1(0)]TJ
/F13 1 Tf
6.725 0 0 5.977 397.644 563.584 Tm
(1)Tj
/F8 1 Tf
8.966 0 0 8.966 458.929 559.559 Tm
[(24)-4810.7(31)]TJ
-16.0159 -1.0559 TD
[(Breathlessness)-335.9(grade)-333.1(1*)-6334.6(10)-5228(7)]TJ
T*
[(Breathlessness)-335.9(grade)-333.1(2**)-5834.5(10)-5228(5)]TJ
T*
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T*
[(up)15.5(pe)15.1(r)-434.8(a)0(i)18.4(r)0(w)15.7(a)0(y)15.1(s)-434.4(th)18.9(at)-431.1(do)-428.3(no)21.2(t)-435.6(a)0(f)24.9(f)0(e)19.2(c)0(t)-431.1(g)0(a)20.8(s)-440.1(di)18.8(f)20.4(f)0(u)13.9(s)0(i)17.7(n)0(g)-422.6(c)0(a)14.7(p)0(a)15.1(c)0(i)18.4(t)0(y)81.5(.)]TJ
ET
1 i 
58.28 768.302 478.205 -0.51 re
f
180.85 753.335 165.033 -0.283 re
f
362.494 753.335 173.99 -0.283 re
f
58.28 727.427 478.205 -0.454 re
f
58.28 625.833 478.205 -0.51 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 772.667 Tm
[(Table)-331.9(3.)-336.7(\261)-567.2(Mean)-236.1(single-breath)-240.6(transfer)-232.6(factor)-238.7(of)-235.5(the)-233.6(lung)-237.8(for)-237.6(carbon)-234.2(monoxide)-235(\()]TJ
/F14 1 Tf
34.5357 0 TD
(T)Tj
/F2 1 Tf
7.173 0 0 7.173 373.436 772.667 Tm
(L,CO)Tj
8.966 0 0 8.966 390.161 772.667 Tm
[(\))-236.1(b)0(y)-237.9(respiratory)-238.3(symptoms)-235.3(and)-234.5(by)-237.9(sex)]TJ
/F8 1 Tf
-15.7883 -1.7135 TD
[(Females)-17906.3(Males)]TJ
-6.9868 -1.6629 TD
(Symptom)Tj
0.5058 -1.0559 TD
(present)Tj
6.5632 1.0559 TD
(Symptom)Tj
0.6702 -1.0559 TD
(absent)Tj
6.481 1.0559 TD
[(p-value)-3325.2(Symptom)]TJ
6.7971 -1.0559 TD
(present)Tj
7.0627 1.0559 TD
(Symptom)Tj
0.6639 -1.0559 TD
(absent)Tj
6.7339 1.0559 TD
(p-value)Tj
-49.717 -3.054 TD
[(Morning)-335.6(cough)-8071.6(7.31\2131.78)-2812.9(7.95\2131.51)-3792.9(0.0002)-3319.9(9.76\2132.56)-2844.5(1)32.1(1.15\2132.26)]TJ
/F10 1 Tf
49.717 0 TD
(<)Tj
/F8 1 Tf
0.5501 0 TD
(0.0001)Tj
-50.2671 -1.0559 TD
[(Phlegm)-334.7(when)-336.2(coughing)-4759.2(7.30\2131.55)-2812.9(7.93\2131.57)-3792.9(0.0007)-2820.4(10.23\2132.74)-2844(1)32.1(1.05\2132.24)-3792.9(0.0004)]TJ
T*
[(Chronic)-333.1(cough)-8356.1(7.04\2131.83)-2812.9(7.89\2131.55)-3792.9(0.001)30.7(1)-3350.7(9.66\2132.66)-2812.9(10.99\2132.33)-3792.4(0.0001)]TJ
T*
[(Wheezing)-10303.2(7.50\2131.69)-2812.9(7.95\2131.53)-3792.9(0.004)-3320.4(10.32\2132.41)-2844(1)32.1(1.07\2132.35)-3792.9(0.0007)]TJ
T*
[(Breathlessness)-335.9(grade)-339.4(1*)-4633.7(7.03\2131.51)-2812.9(8.03\2131.56)]TJ
6.725 0 0 5.977 284.372 681.108 Tm
(+)Tj
/F10 1 Tf
8.966 0 0 8.966 313.455 677.14 Tm
(<)Tj
/F8 1 Tf
0.5501 0 TD
[(0.0001)-3319.9(9.70\2132.13)-2844.5(1)32.1(1.19\2132.21)]TJ
6.725 0 0 5.977 474.973 681.108 Tm
(+)Tj
/F10 1 Tf
8.966 0 0 8.966 504.057 677.14 Tm
(<)Tj
/F8 1 Tf
0.5501 0 TD
(0.0001)Tj
-50.2671 -1.0559 TD
[(Breathlessness)-335.9(grade)-339.4(2**)-4133.7(7.05\2131.57)-2812.9(8.03\2131.56)]TJ
6.725 0 0 5.977 284.372 671.641 Tm
(+)Tj
/F10 1 Tf
8.966 0 0 8.966 313.455 667.672 Tm
(<)Tj
/F8 1 Tf
0.5501 0 TD
[(0.0001)-3319.9(8.79\2132.16)-2844.5(1)32.1(1.19\2132.21)]TJ
6.725 0 0 5.977 474.973 671.641 Tm
(+)Tj
/F10 1 Tf
8.966 0 0 8.966 504.057 667.672 Tm
(<)Tj
/F8 1 Tf
0.5501 0 TD
(0.0001)Tj
-50.2671 -1.0559 TD
[(Breathlessness)-335.9(grade)-339.4(3***)-3633.6(6.85\2132.92)-2812.9(8.03\2131.56)]TJ
6.725 0 0 5.977 284.372 662.173 Tm
(+)Tj
8.966 0 0 8.966 318.387 658.205 Tm
[(0.097)-3819.9(5.92\2131.69)-2844.5(1)32.1(1.19\2132.21)]TJ
6.725 0 0 5.977 474.973 662.173 Tm
(+)Tj
/F10 1 Tf
8.966 0 0 8.966 504.057 658.205 Tm
(<)Tj
/F8 1 Tf
0.5501 0 TD
(0.0001)Tj
-50.2671 -1.0559 TD
[(Breathlessness)-335.9(grade)-339.4(4****)-4733.3(\261)-6569(\261)-11589.4(4.80\2133.18)-2844.5(1)32.1(1.19\2132.21)]TJ
6.725 0 0 5.977 474.973 652.705 Tm
(+)Tj
8.966 0 0 8.966 508.989 648.737 Tm
(0.0001)Tj
-50.2671 -1.0559 TD
[(Bronchial)-334.2(asthma)-7285.9(7.82\2131.66)-2812.9(7.83\2131.58)-3792.9(0.98)-3845.7(1)25.8(1.08\2132.44)-2812.9(10.86\2132.39)-3792.4(0.76)]TJ
T*
[(COLD)-11615.3(5.53\2131.34)-2812.9(7.96\2131.48)]TJ
/F10 1 Tf
28.4594 0 TD
(<)Tj
/F8 1 Tf
0.5501 0 TD
[(0.0001)-3319.9(7.38\2132.45)-2844.5(1)32.1(1.05\2132.24)]TJ
/F10 1 Tf
20.7075 0 TD
(<)Tj
/F8 1 Tf
0.5501 0 TD
(0.0001)Tj
-50.2671 -1.9411 TD
[(Data)-268.8(are)-264.6(presented)-271.2(as)-265.5(mean\213)]TJ
6.276 0 0 6.276 160.724 612.397 Tm
0.0001 Tc
(SD)Tj
8.966 0 0 8.966 171.042 612.397 Tm
0 Tc
[(in)-266.9(mmol)]TJ
/F7 1 Tf
3.3448 0.2213 TD
(.)Tj
/F8 1 Tf
0.2719 -0.2213 TD
(min)Tj
6.725 0 0 5.977 217.304 616.365 Tm
(-1)Tj
/F7 1 Tf
8.966 0 0 8.966 222.86 614.381 Tm
(.)Tj
/F8 1 Tf
0.2719 -0.2213 TD
(kPa)Tj
6.725 0 0 5.977 238.62 616.365 Tm
(-1)Tj
8.966 0 0 8.966 244.176 612.397 Tm
(.)Tj
6.725 0 0 5.977 248.768 616.365 Tm
(#)Tj
8.966 0 0 8.966 252.17 612.397 Tm
[(:)-267.4(mean)-265(of)-265.5(two)-263.4(measurements)-274.3(\(n)]TJ
/F10 1 Tf
12.532 0 TD
(=)Tj
/F8 1 Tf
0.5501 0 TD
[(1)32.1(121\);)-266.4(*:)-266.9(breathlessness)-268(when)-266.6(walking)-269.8(up)-264.6(hills)]TJ
-34.7065 -1.0559 TD
[(\(excluding)-303.7(grades)-302.1(2\2614\);)-304.3(**:)-304.4(breathlessness)-305.9(when)-304.5(walking)-301.4(up)-302.5(stairs)-308.3(\(excluding)-303.7(grades)-302.2(3)-303(and)-301.8(4\);)-305.3(***:)-303.8(breathlessness)-305.9(when)-298.2(walking)-307.8(on)]TJ
T*
[(ground)-219.2(\(excluding)-221.5(grade)-212.9(4\);)-223.1(****:)-214.8(breathlessness)-223.7(at)-216.1(rest;)]TJ
6.725 0 0 5.977 259.257 597.43 Tm
(+)Tj
8.966 0 0 8.966 262.998 593.461 Tm
[(:)-223.2(mean)]TJ
/F3 1 Tf
2.8516 0 TD
(T)Tj
/F8 1 Tf
7.173 0 0 7.173 293.556 593.461 Tm
(L,CO)Tj
8.966 0 0 8.966 311.527 593.461 Tm
[(in)-222.7(those)-215.8(who)-216.8(report)-222.3(no)-214(breathlessness)-223.7(\(grade)-219.7(0\).)-217.8(COLD:)-223.3(chronic)]TJ
-28.2444 -1.0559 TD
[(obstructive)-338.4(lung)-329.1(disease.)]TJ
ET
0 0 0 0 k
0 0 0 1 K
0 J 0 j 0.5 w 3.864 M []0 d
/GS3 gs
130.75 283.172 m
130.75 283.897 131.338 284.485 132.063 284.485 c
132.788 284.485 133.375 283.897 133.375 283.172 c
133.375 282.447 132.788 281.86 132.063 281.86 c
131.338 281.86 130.75 282.447 130.75 283.172 c
b
100.397 284.047 m
100.397 284.772 100.984 285.36 101.709 285.36 c
102.434 285.36 103.022 284.772 103.022 284.047 c
103.022 283.322 102.434 282.735 101.709 282.735 c
100.984 282.735 100.397 283.322 100.397 284.047 c
b
93.597 310.609 m
93.597 188.86 l
102.597 182.86 m
284.096 182.86 l
93.597 189.11 m
91.472 189.11 l
93.597 203.86 m
91.472 203.86 l
93.597 218.78 m
91.472 218.78 l
93.597 234.209 m
91.472 234.209 l
93.597 249.242 m
91.472 249.242 l
93.597 264.275 m
91.472 264.275 l
93.597 279.732 m
91.472 279.732 l
93.597 295.105 m
91.472 295.105 l
93.597 310.365 m
91.472 310.365 l
S
BT
/F20 1 Tf
10 0 0 10 75.847 306.98 Tm
0 0 0 1 k
/GS4 gs
(120)Tj
0.0875 -1.512 TD
-0.06 Tc
[(11)-60(0)]TJ
-0.075 -1.562 TD
0 Tc
(100)Tj
0.4625 -1.5649 TD
(90)Tj
-0.0125 -1.4856 TD
(80)Tj
0.0262 -1.4625 TD
(70)Tj
0 -1.5771 TD
(60)Tj
-0.0177 -1.4854 TD
(50)Tj
0.004 -1.4375 TD
(40)Tj
ET
/GS3 gs
102.864 182.979 m
102.864 181.042 l
133.114 182.854 m
133.114 180.917 l
163.363 182.842 m
163.363 180.905 l
193.302 182.831 m
193.302 180.893 l
223.24 182.819 m
223.24 180.881 l
253.66 182.807 m
253.66 180.87 l
S
BT
10 0 0 10 89.847 171.173 Tm
/GS4 gs
[(Asymp)-1597.5(0)-2505.1(1)-2616.9(2)-2494(3)-2631.5(4)]TJ
4.8875 -1.8375 TD
(Breathlessness grade)Tj
/F22 1 Tf
0 10 -10 0 67.347 226.61 Tm
(T)Tj
/F20 1 Tf
0 8 -8 0 67.347 231.62 Tm
(L,CO)Tj
0 10 -10 0 67.347 246.932 Tm
(  % pred)Tj
ET
/GS3 gs
100.365 280.422 m
102.615 280.422 l
131.149 285.797 m
133.211 285.797 l
131.341 279.093 m
133.341 279.093 l
132.16 285.784 m
132.16 284.36 l
132.285 280.672 m
132.285 280.297 l
161.722 279.047 m
163.784 279.047 l
162.659 279.172 m
162.659 277.047 l
162.659 274.985 m
162.659 269.422 l
161.659 269.422 m
163.659 269.422 l
191.722 283.485 m
193.784 283.485 l
192.722 283.672 m
192.722 281.485 l
192.659 279.485 m
192.659 277.297 l
191.659 277.36 m
193.722 277.36 l
221.529 284.485 m
223.529 284.485 l
222.563 284.547 m
222.563 275.547 l
222.596 273.61 m
222.596 264.61 l
221.597 264.672 m
223.659 264.672 l
191.784 272.922 m
193.909 272.922 l
192.784 273.047 m
192.784 264.235 l
191.597 264.36 m
193.847 264.36 l
222.034 245.922 m
224.034 245.922 l
222.909 246.047 m
222.909 230.547 l
221.909 230.735 m
224.096 230.735 l
252.221 234.797 m
254.346 234.797 l
253.221 234.923 m
253.221 202.798 l
251.955 202.985 m
254.455 202.985 l
102.66 283.842 m
130.878 283.78 l
133.222 283.422 m
161.722 276.235 l
163.722 276.11 m
191.722 280.422 l
193.597 280.235 m
221.722 274.735 l
252.846 218.735 m
223.033 238.172 l
222.596 238.11 m
193.097 268.235 l
162.597 273.235 m
192.722 268.422 l
132.597 281.61 m
162.722 273.047 l
102.097 282.735 m
132.222 281.86 l
S
251.846 218.798 m
251.846 219.522 252.434 220.11 253.159 220.11 c
253.884 220.11 254.471 219.522 254.471 218.798 c
254.471 218.073 253.884 217.485 253.159 217.485 c
252.434 217.485 251.846 218.073 251.846 218.798 c
b
221.573 238.297 m
221.573 239.022 222.161 239.61 222.885 239.61 c
223.61 239.61 224.198 239.022 224.198 238.297 c
224.198 237.573 223.61 236.985 222.885 236.985 c
222.161 236.985 221.573 237.573 221.573 238.297 c
b
191.448 268.547 m
191.448 269.272 192.036 269.86 192.761 269.86 c
193.485 269.86 194.073 269.272 194.073 268.547 c
194.073 267.822 193.485 267.235 192.761 267.235 c
192.036 267.235 191.448 267.822 191.448 268.547 c
b
161.573 273.047 m
161.573 273.772 162.161 274.36 162.886 274.36 c
163.611 274.36 164.198 273.772 164.198 273.047 c
164.198 272.322 163.611 271.735 162.886 271.735 c
162.161 271.735 161.573 272.322 161.573 273.047 c
b
130.823 281.672 m
130.823 282.397 131.411 282.985 132.136 282.985 c
132.861 282.985 133.448 282.397 133.448 281.672 c
133.448 280.947 132.861 280.36 132.136 280.36 c
131.411 280.36 130.823 280.947 130.823 281.672 c
b
100.324 282.922 m
100.324 283.647 100.911 284.235 101.636 284.235 c
102.361 284.235 102.949 283.647 102.949 282.922 c
102.949 282.197 102.361 281.61 101.636 281.61 c
100.911 281.61 100.324 282.197 100.324 282.922 c
b
100.45 286.422 m
102.7 286.422 l
101.597 286.485 m
101.597 285.36 l
101.472 281.735 m
101.472 280.36 l
132.222 281.235 m
132.222 279.1 l
S
0 0 0 0 k
161.5 276.422 m
161.5 277.147 162.088 277.735 162.813 277.735 c
163.538 277.735 164.125 277.147 164.125 276.422 c
164.125 275.697 163.538 275.11 162.813 275.11 c
162.088 275.11 161.5 275.697 161.5 276.422 c
b
191.5 280.422 m
191.5 281.147 192.088 281.735 192.812 281.735 c
193.537 281.735 194.125 281.147 194.125 280.422 c
194.125 279.697 193.537 279.11 192.812 279.11 c
192.088 279.11 191.5 279.697 191.5 280.422 c
b
221.25 274.672 m
221.25 275.397 221.837 275.985 222.562 275.985 c
223.287 275.985 223.875 275.397 223.875 274.672 c
223.875 273.947 223.287 273.36 222.562 273.36 c
221.837 273.36 221.25 273.947 221.25 274.672 c
b
BT
/F8 1 Tf
7.97 0 0 7.97 58.28 138.104 Tm
0 g
/GS2 gs
[(Fig.)-327.1(1.)-331.2(\261)-332.2(Single-breat)8.8(h)-310.9(transfer)-312.5(factor)-308.2(of)-316.1(the)-308.1(lung)-314.1(for)-314.1(carbon)-305.6(monoxide)]TJ
0 -1.067 TD
(\()Tj
/F3 1 Tf
0.3201 0 TD
(T)Tj
/F8 1 Tf
6.376 0 0 6.376 65.254 129.6 Tm
(L,CO)Tj
7.97 0 0 7.97 79.54 129.6 Tm
[(\))-232.8(with)-240.7(respect)-235(to)-232.9(grade)-236.6(of)-237.8(breathless)9.6(ness)-234.8(in)-232.9(males)-240.3(\()]TJ
/F4 1 Tf
19.8101 0 TD
(*)Tj
/F8 1 Tf
0.9958 0 TD
0.2408 Tc
(,n)Tj
/F10 1 Tf
0.9887 0 TD
0 Tc
(=)Tj
/F8 1 Tf
0.5477 0 TD
[(576\))-233.6(and)]TJ
-25.0098 -1.0599 TD
[(females)-228.1(\()]TJ
/F15 1 Tf
3.6135 0 TD
(s)Tj
/F8 1 Tf
0.8322 0 TD
0.2337 Tc
(,n)Tj
/F10 1 Tf
0.9816 0 TD
0 Tc
(=)Tj
/F8 1 Tf
0.5477 0 TD
[(545\).)-232.6(Data)-229.2(are)-233.7(presented)-230.8(as)-237.8(mean\213)]TJ
5.579 0 0 5.579 214.129 121.153 Tm
(SEM)Tj
7.97 0 0 7.97 227.452 121.153 Tm
(\(n)Tj
/F10 1 Tf
0.818 0 TD
(=)Tj
/F8 1 Tf
0.5477 0 TD
[(1)30.5(121\).)-232.6(Asymp:)]TJ
-22.5913 -1.0599 TD
[(asymptomati)9.1(c.)]TJ
ET
308.976 301.606 227.168 -0.51 re
f
308.976 266.23 227.168 -0.51 re
f
308.976 174.047 227.168 -0.454 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 308.976 334.318 Tm
[(Table)-331.9(4.)-336.7(\261)-1009.8(Multiple)-679.4(linear)-673.1(regression)-679.7(of)-671.8(single-breath)]TJ
0 -1.0559 TD
[(transfer)-371.7(factor)-371.5(of)-374.6(the)-372.7(lung)-370.6(for)-370.4(carbon)-373.3(monoxide)-374.1(with)-374.4(res-)]TJ
0 -1.0496 TD
[(pect)-378.5(to)-374.7(each)-373.1(respiratory)-377.4(symptom)-374.9(adjusted)-376(for)-376.8(sex,)-373.6(age,)]TJ
0 -1.0559 TD
[(height)-334.2(and)-335.7(smoking)-333.2(habits*)]TJ
/F8 1 Tf
9.3832 -1.7135 TD
(r)Tj
6.276 0 0 6.276 427.238 290.608 Tm
0.0001 Tc
(SEM)Tj
8.966 0 0 8.966 457.398 290.608 Tm
0 Tc
[(p-value)-1902.5(p-value)]TJ
4.249 -1.0559 TD
(interaction)Tj
0.2086 -1.0496 TD
[(with)-334.8(sex)]TJ
6.725 0 0 5.977 528.038 275.698 Tm
(#)Tj
8.966 0 0 8.966 308.976 253.757 Tm
[(Morning)-335.6(cough)-2248.2(0.3071)-1277.6(0.1)29.7(151)-2356.9(0.01)-2846.7(0.12)]TJ
0 -1.0559 TD
[(Phlegm)-334.7(when)]TJ
0.3351 -1.0559 TD
(coughing)Tj
8.1629 1.0559 TD
[(0.1355)-1277.6(0.1)29.7(143)-2356.9(0.24)-2846.7(0.46)]TJ
-8.498 -2.1119 TD
[(Chronic)-333.1(cough)-2532.7(0.31)30.2(16)-1307.8(0.1586)-2327.2(0.05)-2846.7(0.66)]TJ
0 -1.0559 TD
[(Wheezing)-4479.8(0.1220)-1277.6(0.1020)-2327.2(0.23)-2846.7(0.98)]TJ
T*
(Breathlessness)Tj
0.3351 -1.0496 TD
(score)Tj
6.725 0 0 5.977 330.633 200.976 Tm
(+)Tj
8.966 0 0 8.966 317.934 187.54 Tm
(Males)Tj
0 -1.0559 TD
(Females)Tj
7.1765 1.0559 TD
(-0.7356)Tj
0 -1.0559 TD
(-0.1678)Tj
4.3502 1.0559 TD
(0.0936)Tj
0 -1.0559 TD
(0.0874)Tj
/F10 1 Tf
4.5272 1.0559 TD
(<)Tj
/F8 1 Tf
0.5501 0 TD
(0.01)Tj
-0.0253 -1.0559 TD
(0.06)Tj
/F10 1 Tf
4.1794 0.4426 TD
(<)Tj
/F8 1 Tf
0.5501 0 TD
(0.01)Tj
-22.3072 -2.3901 TD
[(*:)-323.8(n)]TJ
/F10 1 Tf
1.5934 0 TD
(=)Tj
/F8 1 Tf
0.5564 0 TD
[(1)32.1(121.)]TJ
6.725 0 0 5.977 351.042 164.579 Tm
(#)Tj
8.966 0 0 8.966 354.387 160.611 Tm
[(:)-324.4(p-value)-328.1(for)-322.9(the)-329.4(interaction)-326.7(term)-325.5(between)-330.2(sex)-321.9(and)]TJ
-5.0647 -1.0559 TD
[(each)-395.6(of)-392(the)-392.7(respiratory)-401.1(symptoms;)]TJ
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[(In)-390.1(th)18.8(e)-399.5(p)0(r)14(e)0(s)19.6(e)0(n)20.8(t)-401.5(st)17.7(ud)21.2(y)67.5(,)-393(th)13.2(e)-393.8(r)0(e)13.5(l)0(a)18.4(t)0(i)16.5(o)0(n)21.2(s)0(h)14.4(i)0(p)-385.2(b)0(e)15.1(t)0(w)14.9(e)0(e)20.4(n)-399.1(ch)20.8(ro)13.9(ni)18.8(c)]TJ
-1.0015 -1.0641 TD
[(co)15.1(ug)15.5(h)-365(a)0(n)20.8(d)-365(de)15.1(cr)19.2(ea)14.7(se)19.6(d)]TJ
/F3 1 Tf
8.7464 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 401.839 452.579 Tm
0.0001 Tc
[(L,)21.9(CO)]TJ
9.963 0 0 9.963 423.042 452.579 Tm
0 Tc
[(wa)16.9(s)-366.2(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.5(a)0(n)15.1(t)0(l)16.5(y)-365(st)17.7(ro)19.6(ng)15.5(er)-356.3(in)]TJ
-11.4152 -1.0698 TD
[(cu)15.1(rr)18(en)15.1(t)-435.6(s)0(m)16.9(o)0(k)15.5(e)0(r)19.2(s)-440.1(an)20.8(d)-438.9(i)0(n)-430.7(e)0(x)20.8(s)0(m)16.9(o)0(k)15.5(e)0(r)19.2(s)-440.1(th)18.8(an)-428.7(in)-430.7(no)15.5(ns)20(mo)18.1(ke)15.1(rs)18.5(.)]TJ
T*
[(Th)17.1(e)-206(m)0(e)17.7(c)0(h)15.1(a)0(n)20.8(i)0(s)17.7(m)0(s)-199.3(c)0(a)20.4(u)0(s)14.3(i)0(n)18.9(g)-205.6(ch)20.8(ro)19.6(ni)13.2(c)-200.3(c)0(o)15.1(u)0(g)21.2(h)-205.6(in)-197.4(cu)20.8(rr)18(en)15.1(t)-202.3(s)0(m)16.9(o)0(k)15.5(e)0(r)19.2(s)]TJ
T*
[(ma)12(y)73.2(,)-296.3(to)-288.4(a)-297.1(g)0(r)13.9(e)0(a)20.4(t)0(e)18.4(r)-298.3(ex)15.1(te)18.4(nt)-288.4(th)18.9(an)-292.2(in)-288.4(no)21.2(ns)14.4(mo)18.1(ke)20.8(rs)12.7(,)-296.3(b)0(e)-286.5(r)0(e)13.5(l)13.9(at)12.8(ed)-286.5(to)]TJ
0 -1.0641 TD
[(re)13.5(du)21.2(ce)14.7(d)]TJ
/F3 1 Tf
3.6021 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 350.589 410.003 Tm
0.0001 Tc
[(L,)21.9(CO)]TJ
9.963 0 0 9.963 368.107 410.003 Tm
0 Tc
[(.)-518.2(R)11.6(ed)15.1(uc)15.1(ed)]TJ
/F3 1 Tf
4.7118 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 420.435 410.003 Tm
0.0001 Tc
[(L,)21.9(CO)]TJ
9.963 0 0 9.963 443.225 410.003 Tm
0 Tc
[(is)-505.9(ca)14.7(us)20(ed)-514.1(by)-508(no)15.5(t)-515.3(o)0(n)15.5(l)0(y)]TJ
-13.4411 -1.0698 TD
[(de)15.1(fe)19.2(ct)12.8(s)-206.8(i)0(n)-203.1(t)0(h)18.8(e)-211.7(al)18.4(ve)15.1(ol)18.9(ar)-202.7(ca)14.7(pi)18.9(ll)16.5(ar)19.2(y)-211.3(m)0(e)17.7(m)0(b)18.1(r)0(a)13.5(n)0(e)-201.1(b)0(u)15.5(t)-208(al)18.5(so)-201.9(di)13.2(st)17.7(ur)19.6(b-)]TJ
T*
[(an)15.1(ce)14.7(s)-229.6(i)0(n)-225.8(t)0(h)18.9(e)-234.5(ve)15.1(nt)18.9(il)16.5(at)18.5(io)18.9(n/)13.2(pe)20.8(rf)18(us)14.4(io)18.9(n)-234.1(r)0(a)19.2(t)0(i)16.5(o)-234.1(of)-225.1(th)18.8(e)-234.5(l)0(u)18.8(n)0(g)15.5(s)0(.)-224.3(S)0(u)16.3(c)0(h)-223.9(a)]TJ
T*
[(ve)15.1(nt)18.9(il)16.5(at)18.5(io)18.9(n/)13.2(pe)20.8(rf)18(us)14.4(io)18.9(n)-393.4(m)0(i)15.7(s)0(m)16.9(a)0(t)18.5(c)0(h)-383.2(m)0(a)17.7(y)-393.4(be)-383.2(mo)18.1(re)-384.8(fr)18(eq)15.1(ue)20.8(nt)-385.2(in)]TJ
0 -1.0641 TD
[(sm)16.9(ok)15.5(er)19.2(s)-218.2(t)0(h)18.9(a)0(n)-206.8(i)0(n)-203.1(n)0(o)15.5(n)0(s)20(m)0(o)18.1(k)0(e)15.1(r)0(s)18.4(.)-210.9(It)-210.4(i)13.9(s)-218.2(po)21.2(ss)13.2(i)13.9(b)0(l)13.2(e)-211.7(th)18.9(at)-209.2(th)18.9(e)]TJ
/F3 1 Tf
19.6324 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 510.349 367.427 Tm
0.0001 Tc
[(L,)21.9(CO)]TJ
9.963 0 0 9.963 530.022 367.427 Tm
0 Tc
(is)Tj
-22.1533 -1.0698 TD
[(ab)15.1(le)-237.6(to)-237.2(re)19.2(fl)17.3(ec)14.7(t)-242.1(e)0(a)14.7(r)0(l)17.3(y)-245.5(lu)18.9(ng)-234.8(fu)13.9(nc)20.8(ti)16.5(on)-240.5(ch)20.8(an)15.1(ge)20.8(s)-246.7(r)0(e)19.2(l)0(a)12.8(t)0(e)18.5(d)-245.5(to)-237.2(mi)15.7(no)21.2(r)]TJ
T*
[(an)15.1(at)18.4(om)18.1(ic)12.8(al)-328.7(mo)12.4(di)18.9(fi)17.3(ca)20.4(ti)16.5(on)15.5(s)-343.4(i)13.9(n)-342.2(s)0(u)14.4(b)0(j)18.9(e)0(c)20.4(t)0(s)-335.2(w)0(i)14.9(t)0(h)-334(c)0(h)20.8(r)0(o)13.9(n)0(i)18.8(c)-342.6(co)20.8(ug)15.5(h,)]TJ
0 -1.0641 TD
[(es)13.9(pe)20.8(ci)12.8(al)18.4(ly)-311.2(in)-316.9(sm)16.9(ok)15.5(er)19.2(s)-326.3([)0(2)19.6(7].)]TJ
1.0015 -1.0528 TD
[(Ph)16.3(le)18.4(gm)-243.7(wh)17.3(en)-240.9(co)15.1(ug)21.2(hi)18.9(ng)-240.5(wa)11.2(s)-246.7(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.5(a)0(n)20.8(t)0(l)16.5(y)-251.2(mo)18.1(re)-242.5(st)17.7(ro)13.9(ng)21.2(ly)]TJ
-1.0015 -1.0698 TD
[(re)13.5(la)18.4(te)18.4(d)-234.1(t)0(o)-225.8(a)-234.5(re)13.5(du)21.2(ce)14.7(d)]TJ
/F3 1 Tf
7.8416 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 392.882 314.362 Tm
0.0001 Tc
[(L,)29(CO)]TJ
9.963 0 0 9.963 412.781 314.362 Tm
0 Tc
[(in)-225.8(yo)21.2(un)15.5(ge)20.8(r)-235.7(t)0(h)13.2(a)0(n)-223.9(i)0(n)-225.8(o)0(l)18.8(d)0(e)15.1(r)-235.7(pe)20.8(op)15.5(le)18.5(.)]TJ
-10.3853 -1.0641 TD
[(In)-373(ol)18.9(de)15.1(r)-383.6(s)0(u)20(b)0(j)18.8(e)0(c)14.7(t)0(s)17.7(,)-381.6(ph)21.2(le)18.4(gm)-374.6(wh)17.3(en)-371.8(co)15.1(ug)21.2(hi)18.9(ng)-371.4(ma)12(y)-376.3(b)0(e)-371.8(p)0(a)15.1(r)0(t)17.3(l)0(y)]TJ
0 -1.0698 TD
[(as)13.9(cr)19.2(ib)18.8(ed)-206.8(to)-208.8(a)-217.4(s)0(l)17.7(o)0(w)17.3(e)0(r)-208.4(c)0(l)18.5(e)0(a)20.4(r)0(i)17.3(n)0(g)-206.4(o)0(f)-208(c)0(i)18.5(l)0(i)16.5(a)0(r)13.5(y)-211.3(mu)18.1(cu)15.1(s,)-207.2(no)21.2(t)-219.4(a)0(f)30.6(f)0(e)13.5(c)0(t)18.5(i)0(n)18.8(g)]TJ
T*
[(th)13.2(e)]TJ
/F3 1 Tf
1.5364 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 330.009 282.444 Tm
0.0001 Tc
[(L,)21.9(CO)]TJ
9.963 0 0 9.963 347.527 282.444 Tm
0 Tc
[(.)-341.8(I)0(n)-333.2(y)0(o)15.5(u)0(n)21.2(g)0(e)15.1(r)-343.8(su)20(bj)18.9(ec)14.7(ts)17.7(,)-341.8(t)0(h)18.9(i)0(s)-335.2(s)0(y)14.4(m)13.2(pt)13.2(om)-334.7(ma)17.7(y)-342.2(b)0(e)-337.7(a)0(n)]TJ
-3.8354 -1.0698 TD
[(in)13.2(di)18.9(ca)20.4(to)13.2(r)-372.2(o)0(f)-367.3(m)0(o)18.1(r)0(e)-367.7(s)0(p)20(e)0(c)14.7(i)0(f)17.3(i)0(c)-362.8(p)0(h)15.5(y)0(s)20(i)0(o)13.2(p)0(a)20.8(t)0(h)18.9(o)0(l)13.2(o)0(g)21.2(i)0(c)18.4(a)0(l)-368.5(c)0(h)20.8(a)0(n)15.1(g)0(e)15.1(s)-371.8(in)]TJ
0 -1.0641 TD
[(th)13.2(e)-365.4(t)0(e)18.4(r)0(m)16.5(i)0(n)18.8(a)0(l)-357.1(a)0(i)12.8(r)0(s)18.4(p)0(a)20.8(c)0(e)14.7(s)-366.1(\(a)19.2(lv)18.9(eo)15.1(li)16.5(,)-364.6(a)0(l)18.5(v)0(e)15.1(o)0(l)18.9(a)0(r)-356.3(d)0(u)15.5(c)0(t)18.4(s)0(\))-357.1(l)0(e)18.4(a)0(d)15.1(i)0(n)18.8(g)-365(to)]TJ
0 -1.0698 TD
[(de)15.1(cr)19.2(ea)14.7(se)19.6(d)]TJ
/F3 1 Tf
4.1484 0 TD
(T)Tj
/F8 1 Tf
7.97 0 0 7.97 356.088 250.526 Tm
0.0001 Tc
[(L,)29(CO)]TJ
9.963 0 0 9.963 373.549 250.526 Tm
0 Tc
(.)Tj
-5.4459 -1.0527 TD
[(Th)17.1(eo)15.1(re)19.2(ti)16.5(ca)14.7(ll)16.5(y)73.2(,)-199.6(th)13.2(e)-200.3(o)0(b)15.5(s)0(e)19.6(r)0(v)19.6(e)0(d)-195.4(r)0(e)19.2(l)0(a)12.8(t)0(i)22.2(o)0(n)15.5(s)0(h)20(i)0(p)-197.4(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)-199.9(re)13.5(sp)20(ir)17.3(a-)]TJ
-1.0015 -1.0641 TD
[(to)13.2(ry)-338.9(sy)20(mp)18.1(to)18.9(ms)-341.6(an)20.8(d)-347.9(r)0(e)13.5(d)0(u)21.2(c)0(e)14.7(d)-347.9(si)17.7(ng)21.2(le)18.4(-b)13.9(re)19.2(at)18.5(h)-347.9(d)0(i)18.9(f)14.7(fu)19.6(si)17.7(ng)-337.3(ca)14.7(pa)20.8(-)]TJ
0 -1.0698 TD
[(ci)12.8(ty)-322.6(of)-321.8(th)13.2(e)-331.2(l)0(u)18.8(n)0(g)-325.9(f)0(o)19.6(r)-332.4(ca)14.7(rb)19.6(on)-325.9(mo)18.1(no)15.5(xi)18.9(de)-326.3(co)20.8(ul)18.9(d)-336.5(b)0(e)-320.6(d)0(r)13.9(i)0(v)18.9(e)0(n)-326.3(b)0(y)]TJ
T*
[(su)14.4(bj)18.9(ec)14.7(t)13.9(s)-360.5(wi)14.9(th)-351(ch)20.8(ro)13.9(ni)18.9(c)-359.7(o)0(b)21.2(s)0(t)17.7(r)0(u)14(c)0(t)18.4(i)0(v)18.8(e)-359.7(lu)18.9(ng)-354.3(di)18.9(se)19.6(as)13.9(e.)-348.7(Ho)17.3(we)16.9(ve)20.8(r)37.5(,)]TJ
0 -1.0641 TD
[(th)13.2(e)-200.3(r)0(e)13.5(l)0(a)18.4(t)0(i)16.5(o)0(n)21.2(s)0(h)14.4(i)0(p)-191.7(b)0(e)15.1(t)0(w)14.9(e)0(e)20.4(n)-205.6(si)17.7(ng)21.2(le)12.8(-b)19.6(re)19.2(at)12.8(h)-199.9(d)0(i)18.8(f)14.7(fu)19.6(si)17.7(ng)-195(ca)14.7(pa)20.8(ci)18.5(ty)-197.4(of)]TJ
0 -1.0698 TD
[(th)13.2(e)-365.4(l)13.9(un)15.5(g)-365(f)0(o)19.6(r)-366.6(ca)14.7(rb)19.6(on)-354.3(mo)12.4(no)21.2(xi)18.9(de)-360.4(an)20.8(d)-365(r)0(e)19.2(s)0(p)14.3(i)0(r)17.3(a)0(t)18.5(o)0(r)19.6(y)-365(sy)14.4(mp)18.1(to)18.8(ms)]TJ
T*
[(re)13.5(ma)17.7(in)18.9(ed)-223.9(si)17.7(gn)15.5(if)17.3(ic)18.4(an)20.8(t)-236.5(e)0(v)20.8(e)0(n)-223.9(a)0(f)19.2(t)0(e)12.8(r)-230(ex)15.1(cl)18.4(ud)21.2(in)13.2(g)-228.4(t)0(h)18.9(e)-234.5(su)20(bj)18.9(ec)14.7(ts)-221.3(wi)14.9(th)]TJ
T*
[(ch)15.1(ro)19.6(ni)13.2(c)-319.8(o)0(b)15.5(s)0(t)17.7(r)0(u)19.6(c)0(t)12.8(i)13.9(ve)-320.6(l)13.9(u)0(n)15.5(g)-325.1(di)18.9(se)19.6(as)14(e.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(us)14.3(,)-421.5(s)0(i)17.7(n)0(g)21.2(l)0(e)12.8(-)0(b)19.6(r)0(e)19.2(a)0(t)12.8(h)-421.9(di)18.9(f)20.4(f)0(u)13.9(s)0(i)17.7(n)0(g)-411.2(c)0(a)14.7(p)0(a)20.8(c)0(i)18.4(t)0(y)-419.3(o)0(f)-412.8(t)0(h)18.8(e)-422.3(lu)18.9(ng)-416.9(fo)19.6(r)]TJ
-1.0015 -1.0698 TD
[(ca)14.7(rb)19.6(on)-399.9(mo)18.1(no)15.5(xi)18.9(de)-394.6(me)12(as)19.6(ur)19.6(em)12(en)20.8(ts)-397.8(ar)19.2(e)-410.9(a)0(b)20.8(l)0(e)-397(t)0(o)-396.6(d)0(i)13.2(f)20.4(fe)19.2(re)13.5(nt)18.9(ia)18.4(te)]TJ
T*
[(be)15.1(tw)14.9(ee)20.4(n)-609.7(r)0(e)19.2(s)0(p)14.4(i)0(r)17.3(a)0(t)18.5(o)0(r)19.6(y)-609.7(sy)14.4(mp)18.1(to)18.9(ma)17.7(ti)16.5(c)-610.1(a)0(n)20.8(d)-609.7(no)15.5(ns)20(ym)18.1(pt)13.2(om)18.1(at)18.4(ic)]TJ
0 -1.0641 TD
[(su)14.4(bj)18.9(ec)14.7(t)13.9(s)-445.8(in)-436.4(a)-445(g)0(e)15.1(n)0(e)15.1(r)0(a)19.2(l)-447(po)21.2(pu)15.5(la)18.4(ti)16.5(on)-434(sa)13.9(mp)18.1(le)18.4(.)-444.3(T)0(h)17.1(e)-445(lo)18.9(ng)15.5(-t)17.3(er)19.2(m)]TJ
0 -1.0698 TD
[(im)15.7(pl)13.2(i)13.9(c)0(a)14.7(t)0(i)16.5(o)0(n)21.2(s)-320.6(of)-316.1(a)-319.8(r)0(e)19.2(d)0(u)15.5(c)0(e)20.4(d)-325.1(si)17.7(ng)21.2(le)18.5(-b)13.9(re)19.2(at)18.5(h)-319.4(d)0(i)13.2(f)20.4(fu)19.6(si)17.7(ng)-314.5(ca)20.4(pa)15.1(ci)18.4(ty)]TJ
ET
1 i 
58.28 739.899 227.168 -0.51 re
f
58.28 723.458 227.168 -0.51 re
f
58.28 460.913 227.168 -0.454 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 772.667 Tm
[(Table)-331.9(5.)-336.7(\261)-952.9(Multiple)-622.5(linear)-616.2(regression)-622.8(of)-614.9(mean)-621.8(single-)]TJ
0 -1.0559 TD
[(breath)-250.8(transfer)-251.5(factor)-245(of)-254.5(the)-246.3(lung)-250.4(for)-250.3(carbon)-246.8(monoxide)-254(with)]TJ
T*
[(respect)-220.1(to)-216.6(sex,)-215.6(age,)-219(height,)-217.6(smoking)-219.4(habits)-221.8(and)-215.5(respiratory)]TJ
T*
(symptoms*)Tj
/F8 1 Tf
14.1317 -1.7072 TD
(r)Tj
6.276 0 0 6.276 219.175 728.957 Tm
0.0001 Tc
(SEM)Tj
8.966 0 0 8.966 251.66 728.957 Tm
0 Tc
(p-value)Tj
/F5 1 Tf
-21.5674 -2.0044 TD
[(Main)-333.3(effects)-335(\(no)-339.5(interaction)-332.7(term)-334.1(entered\))]TJ
/F8 1 Tf
0 -1.0559 TD
[(Intercept)-9681.8(-8.60)]TJ
T*
[(Male)-335.7(sex)-9812.6(1.45)-2448.4(0.14)]TJ
/F10 1 Tf
22.067 0 TD
(<)Tj
/F8 1 Tf
0.5501 0 TD
(0.01)Tj
-22.6171 -1.0496 TD
[(Age)-11521.9(-0.06)-2448.8(0.00)]TJ
/F10 1 Tf
22.067 0 TD
(<)Tj
/F8 1 Tf
0.5501 0 TD
(0.01)Tj
-22.6171 -1.0559 TD
[(Height)-10804.3(0.09)-2448.4(0.01)]TJ
/F10 1 Tf
22.067 0 TD
(<)Tj
/F8 1 Tf
0.5501 0 TD
(0.01)Tj
-22.6171 -1.0559 TD
[(Hb)-12281.4(0.03)-2448.4(0.00)]TJ
/F10 1 Tf
22.067 0 TD
(<)Tj
/F8 1 Tf
0.5501 0 TD
(0.01)Tj
-22.6171 -1.0559 TD
[(HbCO)-10574.9(-0.03)-2448.8(0.00)]TJ
/F10 1 Tf
22.067 0 TD
(<)Tj
/F8 1 Tf
0.5501 0 TD
(0.01)Tj
-22.6171 -1.0559 TD
[(Smoking)-334.4(habits)]TJ
0.6639 -1.0559 TD
[(Exsmokers)-8109.9(-0.08)-2448.8(0.13)]TJ
T*
[(Current)-340.3(smokers)-5856.4(-0.21)-2448.8(0.16)]TJ
-0.6639 -1.0559 TD
[(Smoking)-334.4(consumption)]TJ
0.3351 -1.0559 TD
[(\(in)-330.6(pack-yrs\))]TJ
12.8418 1.0559 TD
[(-0.02)-2448.8(0.006)]TJ
/F10 1 Tf
8.89 0 TD
(<)Tj
/F8 1 Tf
0.5501 0 TD
(0.01)Tj
-22.6171 -2.1119 TD
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