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BT
/F1 1 Tf
14.944 0 0 14.944 80.504 720.34 Tm
0.0207 Tc
[(Differences)-334(in)-336.5(airway)-334(responsiveness)-334(to)-332.7(acetaldehyde)-330.2(a)-0.1(nd)]TJ
2.7428 -1.0319 TD
0.0211 Tc
[(methacholine)-333.6(i)2.4(n)-332.3(asthma)-329.8(a)0.3(nd)-332.3(chronic)-329.8(b)-2.2(ronchitis)]TJ
/F2 1 Tf
10.959 0 0 10.959 115.71 667.559 Tm
0 Tc
[(F.)-331(Sa)]TJ
1.9968 0 TD
[(\302)-111.9(nchez-Toril)]TJ
/F3 1 Tf
8.219 0 0 7.305 196.441 672.434 Tm
0 Tw
(#)Tj
/F2 1 Tf
10.959 0 0 10.959 200.523 667.559 Tm
[(,)-334.6(L)0(.)-331(Prieto)]TJ
/F3 1 Tf
4.3817 0 TD
(*)Tj
/F2 1 Tf
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[(,)-334.6(R)0(.)-330.5(Peris)]TJ
/F3 1 Tf
8.219 0 0 7.305 300.189 672.434 Tm
(#)Tj
/F2 1 Tf
10.959 0 0 10.959 304.271 667.559 Tm
[(,)-334.6(J.A.)-330.9(Pe)]TJ
3.4453 0 TD
[(\302)-111.9(rez)]TJ
/F3 1 Tf
8.219 0 0 7.305 362.098 672.434 Tm
(#)Tj
/F2 1 Tf
10.959 0 0 10.959 366.179 667.559 Tm
[(,)-334.6(M)0(.)-329.3(Millan)]TJ
/F3 1 Tf
8.219 0 0 7.305 417.146 672.434 Tm
(#)Tj
/F2 1 Tf
10.959 0 0 10.959 421.285 667.559 Tm
[(,)-329.4(J)0(.)-336.4(Mar\365)]TJ
3.4195 0 TD
-0.0278 Tc
(\302n)Tj
/F3 1 Tf
0.8536 0 TD
0 Tc
(**)Tj
/F4 1 Tf
8.966 0 0 8.966 58.28 630.708 Tm
[(Differ)29.6(ences)-409(in)-406(airway)-403.4(r)30.9(esponsiveness)-410.6(to)-406.1(acetaldehyde)-408.5(and)-403.2(methacholine)-408.3(in)-406.1(asthma)-402.2(and)]TJ
0 -1.0559 TD
[(chr)32.2(onic)-328.9(br)31.4(onchitis.)-323.1(F)123.5(.)-325.4(Sa)]TJ
9.5349 0.0063 TD
(\302)Tj
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[(nchez-T)79.2(oril,)-323(L.)-323.5(Prieto,)-325.2(R.)-328.4(Peris,)-324.5(J.A.)-324.2(Pe)]TJ
15.5923 0.0063 TD
(\302)Tj
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[(r)30.9(ez,)-325.3(M.)-325.3(Millan,)-323.6(J.)-324.6(Mar)]TJ
/F5 1 Tf
9.0734 0 TD
(\365)Tj
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(\302)Tj
/F4 1 Tf
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(n.)Tj
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(#)Tj
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[(ERS)-334.2(Journals)-335.6(Ltd)-334.6(2000.)]TJ
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[(ABSTRACT)66.7(:)-500(Inhaled)-501.4(acetaldehyde)-504.2(may)-498.4(induce)-506.8(bronc)12.2(hoconstriction)-508(in)-499.5(asthmatic)]TJ
T*
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T*
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T*
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T*
[(without)-336.3(airflow)-334(limitation.)]TJ
0.999 -1.0559 TD
[(Bron)11.6(chial)-386.3(provoca)11.8(tion)-385.6(challenges)-383(with)-388.9(methacholine)-387.1(and)-381.3(acetaldehyde)-384.1(wer)11.3(e)-385(per)28.7(-)]TJ
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T*
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T*
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T*
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T*
[(expiratory)-337.6(volume)-333.3(in)-335.1(one)-332(second)-336.3(\(FEV)]TJ
7.173 0 0 7.173 207.95 507.628 Tm
(1)Tj
8.966 0 0 8.966 211.521 507.628 Tm
0.3356 Tc
[(;P)335.6(C)]TJ
7.173 0 0 7.173 229.266 507.628 Tm
0 Tc
(20)Tj
8.966 0 0 8.966 236.466 507.628 Tm
(\).)Tj
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[(The)-362(two)-356.8(types)-364.7(of)-354(challenge)-363.4(yielded)-358.3(a)-359.9(similarly)-366.8(high)-357.9(level)-362.2(of)-354(sensitivity)-364.6(\(100%)-358.3(for)]TJ
-0.999 -1.0559 TD
[(methacholine)-279.6(and)-280.2(92%)-276.2(for)-283.8(acetaldehyde\))-283.4(in)-278.2(r)13.4(evealing)-283.4(airway)-280.6(hyperr)12.9(esponsiveness)-286.4(in)]TJ
T*
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T*
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0 -1.0559 TD
[(dehyde)-270.4(responsiveness)-266.7(wer)11.3(e)-271.2(weakly)-272.9(but)-274.8(significantly)-274.8(correlated)-267.6(\(r)]TJ
/F8 1 Tf
27.8018 0 TD
(=)Tj
/F7 1 Tf
0.5501 0 TD
[(0.42,)-276.2(p)]TJ
/F8 1 Tf
2.8263 0 TD
(=)Tj
/F7 1 Tf
0.5501 0 TD
[(0.001\))-273.2(but)]TJ
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T*
(FEV)Tj
7.173 0 0 7.173 76.139 431.943 Tm
(1)Tj
8.966 0 0 8.966 82.715 431.943 Tm
(\(r)Tj
/F8 1 Tf
0.7587 0 TD
(=)Tj
/F7 1 Tf
0.5501 0 TD
[(0.13,)-333.1(p)]TJ
/F8 1 Tf
2.8832 0 TD
(=)Tj
/F7 1 Tf
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(0.33\).)Tj
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T*
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T*
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/F4 1 Tf
T*
[(Eur)-331.9(Respir)-333.8(J)-334.4(2000;)-333.5(15:)-334.6(260\261265.)]TJ
/F3 1 Tf
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(#)Tj
7.97 0 0 7.97 404.504 631.672 Tm
[(Servicio)-311.1(de)-322(Neumolog)41.1(\302)]TJ
9.0408 0 TD
[(a)-324.1(and)-312.8(*Seccio)]TJ
5.2353 0.0427 TD
(\302)Tj
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0.318 Tc
[(nd)318(e)]TJ
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0 Tc
[(Aler)11.5(golog)36.6(\302)]TJ
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[(a,)-387.1(Hospital)-384.2(Arnau)-382.4(de)-386(V)49.4(ilanova)12(,)]TJ
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[(Hospital)-384.2(Dr)51.3(.)-390.2(Peset)-387.2(and)-391(**Univer)12.8(sidad)-390.4(de)]TJ
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[(V)106.3(alencia,)-326.4(V)106.3(alencia,)-333.5(Spain.)]TJ
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[(Corresponde)11.8(nce:)-333.4(F)75.4(.)-333.3(Sa)]TJ
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(\302)Tj
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[(nchez-T)64.7(oril)]TJ
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[(Servicio)-325.3(de)-329.1(Neumolog)41.1(\302)]TJ
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(a)Tj
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[(Hospital)-327.3(Arnau)-325.5(de)-329.1(V)49.4(ilanova)]TJ
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[(C/)-330.1(San)-331.9(Clemente)-324.2(26)]TJ
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[(46015)-323.8(V)106.3(alencia)]TJ
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(Spain)Tj
0 -1.0599 TD
[(Fax:)-325.1(34)-330.1(963868580)]TJ
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[(Keywords)11.5(:)-334.6(Acetaldehy)10.7(de)]TJ
0 -1.0599 TD
[(airway)-324.7(responsivenes)10(s)]TJ
T*
(asthma)Tj
0 -1.067 TD
[(chronic)-327.3(bronchitis)]TJ
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[(methacholin)11.6(e)]TJ
0 -2.1268 TD
[(Received:)-327.9(April)-324.1(27)-330.1(1999)]TJ
0 -1.0599 TD
[(Accepted)-325.4(after)-331.6(revision)-329.8(October)-322.6(16)-330.1(1999)]TJ
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-1.0015 -1.0755 TD
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0 -1.0698 TD
[(nu)15.5(mb)18.1(er)-316.5(of)-316.1(no)15.5(ns)20(en)15.1(si)17.7(ti)16.5(zi)18.5(ng)-314.5(br)14(on)21.2(ch)15.1(oc)20.8(on)15.5(st)17.7(ri)17.3(ct)18.4(iv)18.9(e)-325.5(s)0(t)12(i)13.9(mu)12.4(li)-313.6([1)13.9(].)]TJ
0 -1.0755 TD
[(These)-237.6(stimuli)-235.4(can)-236.4(be)-229.6(divided)-238.1(into)-229.7(those)-235.4(whi)-8.6(ch)-229.6(are)-232.3(though)-7(t)]TJ
0 -1.0698 TD
[(to)-493.3(ac)-8(t)-492.5(mainly)-502.3(throug)-8.6(h)-490.2(a)-496.3(direc)-8.6(t)-492.5(effect)-489.4(on)-496.6(airway)-502.7(smo-)]TJ
0 -1.0755 TD
[(oth)-317.7(musc)-7.8(le)-317.3(\()]TJ
/F4 1 Tf
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(e.g.)Tj
/F3 1 Tf
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[(met)-8.2(hachol)-7.8(ine)-318.1(and)-315.7(hist)-9(amine\),)-320.2(a)-6.9(n)0(d)-314.5(those)]TJ
-6.7888 -1.0755 TD
[(which)-215.4(may)-216.4(exert)-219.1(an)-212.5(indirect)-220.5(effect)-210.5(on)-212.1(airway)-218.2(smooth)-216.2(mus-)]TJ
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[(cle)-426.6(cell)-8.6(s)-423.1(\()]TJ
/F4 1 Tf
4.1256 0 TD
(e.g.)Tj
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1.8665 0 TD
[(isoca)-8.2(pnic)-426.9(hyperve)-7.7(ntilati)-12(on,)-423(hy)-7.2(perosmola)-10.3(r)]TJ
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[(saline,)-358.8(adenosi)-9.7(ne\).)-357.5(Methacholi)-12.2(ne)-354.7(or)-350.2(hist)-9(amine)-357.3(chall)-9.4(enge)]TJ
0 -1.0698 TD
[(has)-231.5(bee)-8.8(n)-228.4(widely)-241.3(used)-232.3(for)-233.1(the)-232.7(detect)-10.5(ion)-232.3(and)-236(quantitat)-11.5(ion)-232.3(of)]TJ
0 -1.0755 TD
[(AHR)-231.1(in)-225.8(asthmati)-12.7(c)-223.1(patients)-231.5([2,)-231.1(3].)-225.4(Some)-227.7(author)-9(s)-223.9(sugges)-7.4(ted)]TJ
0 -1.0698 TD
[(a)-308.5(cut-o)-8.2(ff)-300.6(limit)-318.1(of)-310.4(8)-308.1(m)0(g)]TJ
/F5 1 Tf
9.1106 0.1992 TD
(.)Tj
/F3 1 Tf
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(mL)Tj
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(-1)Tj
9.963 0 0 9.963 174.728 240.831 Tm
[(for)-312.8(the)-312.4(provoca)-7.7(tive)-315.5(concen-)]TJ
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[(tration)-287.6(causing)-282.9(a)-280(20%)-277.8(fall)-283(in)-277.1(forced)-287.4(expir)-8.2(atory)-281.3(volume)-283.7(in)]TJ
0 -1.0698 TD
[(one)-321.4(second)-330.9(\(FEV)]TJ
7.97 0 0 7.97 128.523 219.458 Tm
(1)Tj
9.963 0 0 9.963 132.491 219.458 Tm
0.3218 Tc
[(;P)321.8(C)]TJ
7.97 0 0 7.97 150.52 219.458 Tm
0 Tc
(20)Tj
9.963 0 0 9.963 158.513 219.458 Tm
[(\))-321(methachol)-10.3(ine)-323.7([3])-324.2(or)-321.8(PC)]TJ
7.97 0 0 7.97 259.54 219.458 Tm
(20)Tj
9.963 0 0 9.963 270.652 219.458 Tm
(his-)Tj
-21.3168 -1.0755 TD
[(tamine)-451.5([2],)-444(since)-446.4(all)-445.6(their)-443.1(nonast)-8.6(hmatic)-451.5(subjects)-446.5(had)-446.6(a)]TJ
T*
(PC)Tj
7.97 0 0 7.97 70.469 198.028 Tm
(20)Tj
9.963 0 0 9.963 81.921 198.028 Tm
[(abo)-8.4(ve)-354.7(this)-361.8(value)-365.5(while)-360(all)-360.3(thei)-8.2(r)-355.2(asthmati)-12.7(c)-354(subje)-7.8(cts)]TJ
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[(with)-273.5(recent)-271.5(symptom)-9.5(s)-263.7(had)-270.2(a)-268.6(lower)-268.2(PC)]TJ
7.97 0 0 7.97 209.82 187.37 Tm
(20)Tj
9.963 0 0 9.963 220.422 187.37 Tm
[(value.)-269.1(However)18.5(,)]TJ
-16.275 -1.0755 TD
[(it)-239.6(is)-244.1(eviden)-7.8(t)-236.5(that)-241.5(many)-245.6(smok)-7.4(ers)-238.8(wi)-7.8(th)-237.2(chroni)-9(c)-240.2(bronchi)-9.7(tis)-241.6(or)]TJ
0 -1.0698 TD
[(chroni)-9(c)-319.8(obstructive)-326.4(pulm)-8.6(onary)-324.5(disease)-324.3(\(COPD\))-326.8(also)-325.7(had)]TJ
0 -1.0755 TD
[(AHR)-282.3(to)-282.7(inhaled)-284.1(hist)-9(amine)-283.3(or)-282(methachol)-10.3(ine)-283.9([4\2619].)-286.2(There-)]TJ
0 -1.0698 TD
[(fore,)-473.7(meas)-8.2(urements)-476.2(of)-469.7(airway)-474.2(respon)-7.8(siven)-7.8(ess)-466(to)-470.5(direc)-8.6(t)]TJ
0 -1.0755 TD
[(broncho)-7.3(const)-7.8(rictors)-265.3(do)-263.3(not)-260.7(appear)-269.2(to)-260(be)-263.7(useful)-266.2(to)-260(disting-)]TJ
T*
[(uish)-427.7(asthm)-10.9(a)-428(from)-430.5(COPD)-430.3(or)-429.9(other)-435(respirato)-11.1(ry)-424.2(disor)-9(ders)]TJ
0 -1.0698 TD
[([10,)-334.3(1)27.7(1].)]TJ
26.1993 24.6799 TD
[(Ai)14.9(rw)15.7(ay)-246.6(re)13.5(sp)20(on)15.5(si)17.7(ve)20.8(ne)15.1(ss)-242.9(al)12.8(so)-247.4(ca)20.4(n)-256.8(b)0(e)-246.6(m)0(e)17.7(a)0(s)13.9(u)0(r)19.6(e)0(d)-246.6(b)0(y)-246.2(s)0(t)17.7(i)0(m)15.7(u)0(l)18.9(i)]TJ
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[(th)13.2(at)-385.6(ap)15.1(pe)20.8(ar)-390.5(to)-390.9(ca)20.4(us)14.4(e)-393.8(b)0(r)13.9(o)0(n)21.2(c)0(h)15.1(o)0(c)20.8(o)0(n)15.5(s)0(t)17.7(r)0(i)17.3(c)0(t)18.4(i)0(o)18.9(n)-399.1(th)18.9(ro)13.9(ug)21.2(h)-399.1(t)0(h)18.8(e)-399.5(re)19.2(-)]TJ
T*
[(le)12.8(as)19.6(e)-245.9(o)0(f)-242.1(m)0(e)17.7(d)0(i)18.9(a)0(t)12.8(o)0(r)19.6(s)-246.7(fr)18(om)-243.7(ce)20.4(ll)16.5(s)-246.7(w)0(i)14.9(t)0(h)18.9(i)0(n)-242.9(t)0(h)18.9(e)-245.9(ai)12.8(rw)21.4(ay)15.1(s,)-235.6(an)15.1(d)-245.5(t)0(h)13.2(e)0(s)19.6(e)]TJ
0 -1.0698 TD
[(ma)12(y)-234.1(b)0(e)-229.6(p)0(r)19.6(e)0(f)19.2(e)0(r)13.5(a)0(b)20.8(l)0(e)-231.9(f)0(o)19.6(r)-235.7(di)18.9(st)17.7(in)13.2(gu)21.2(is)17.7(hi)18.9(ng)-229.1(be)15.1(tw)20.6(ee)14.7(n)-234.1(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-227(w)0(i)14.9(t)0(h)]TJ
0 -1.0755 TD
[(as)13.9(th)18.9(ma)-295.3(an)20.8(d)-302.4(t)0(h)18.8(o)0(s)14.4(e)-297.1(wi)14.9(th)-294.1(CO)18.3(PD)-294.9([1)19.6(2,)-302.7(13].)-317.2(The)-314.1(inhalati)-10.7(on)-308.8(of)]TJ
T*
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T*
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[(Al)14.9(l)-350.3(s)0(u)14.3(b)0(j)18.9(e)0(c)20.4(t)0(s)-346.5(o)0(f)-344.6(b)0(o)15.5(t)0(h)-339.7(g)0(r)13.9(o)0(u)21.2(p)0(s)-344.2(h)0(a)15.1(d)-353.6(be)20.8(en)-343.4(fr)12.4(ee)-343.8(of)-344.6(ac)20.4(ut)13.2(e)-348.3(r)0(e)13.5(-)]TJ
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0 -1.0471 TD
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0 -1.0527 TD
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/F3 1 Tf
7.472 0 0 6.641 81.978 182.381 Tm
(2)Tj
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[(in)18.9(ha)15.1(le)18.4(d)]TJ
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/F3 1 Tf
7.472 0 0 6.641 95.868 171.95 Tm
(2)Tj
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[(a)-15(c)-0.3(ti)-15(ng)-340.1(in)-15(ha)-15(le)-15(d)]TJ
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(b)Tj
/F3 1 Tf
7.472 0 0 6.641 122.287 161.461 Tm
(2)Tj
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[(-a)19.2(go)15.5(ni)18.9(st)17.7(s)-326.3(f)0(o)19.6(r)-326.7(6)-325.1(h)0(.)]TJ
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[(Study)-336.7(desig)-7.8(n)]TJ
/F3 1 Tf
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-1.0015 -1.0471 TD
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25.1977 66.1583 TD
[(ev)15.1(al)18.4(ua)15.1(te)18.4(d)-296.7(f)0(o)13.9(r)-298.3(su)20(it)16.5(ab)15.1(il)16.5(i)13.9(t)0(y)-294.1(a)0(n)20.8(d)-302.4(w)12.4(r)0(i)11.6(t)13.9(te)12.8(n)-296.7(c)0(o)15.1(n)0(s)20(e)0(n)15.1(t)-299.1(w)12.4(a)0(s)-293.3(o)0(b)21.2(t)0(a)12.8(i)13.9(ne)15.1(d)]TJ
0 -1.0471 TD
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0 -1.0528 TD
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7.97 0 0 7.97 400.932 750.727 Tm
(1)Tj
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[(w)12.4(a)0(s)-253.5(m)0(e)17.7(a)0(s)19.6(u)0(r)13.9(e)0(d)-246.6(b)0(e)15.1(f)0(o)19.6(r)0(e)-248.2(a)0(n)15.1(d)-256.9(15)-246.2(mi)15.7(n)]TJ
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[(af)13.5(te)18.4(r)-207.2(i)0(n)18.9(h)0(a)20.8(l)0(i)16.5(n)0(g)-195(2)0(0)15.5(0)]TJ
/F8 1 Tf
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(m)Tj
/F3 1 Tf
0.5634 0 TD
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-7.6026 -1.0528 TD
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0 -1.0471 TD
[(fo)13.9(rm)16.5(ed)-286.5(an)20.8(d)-291(P)0(C)]TJ
7.97 0 0 7.97 369.298 719.376 Tm
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(20)Tj
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0 -1.0471 TD
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0 -1.0527 TD
[(fo)13.9(rm)16.5(ed)-314.9(fi)17.3(rs)18.4(t.)]TJ
/F4 1 Tf
0 -2.2705 TD
[(Meth)-8.2(ods)]TJ
0 -1.8494 TD
[(Pul)-8.8(monary)-471(funct)-9(ion.)]TJ
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[(Sp)16.3(ir)17.3(om)18.1(et)12.8(ry)-447(wa)16.9(s)-457.2(p)0(e)15.1(r)0(f)18(o)0(r)19.6(m)0(e)12(d)-456(wi)14.9(th)-447.8(a)]TJ
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0 -1.0471 TD
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0 -1.0527 TD
[(to)-220.2(st)17.7(an)15.1(da)20.8(rd)13.9(iz)18.4(ed)-218.2(gu)21.2(id)13.2(el)18.4(in)18.9(es)-219.4([2)19.6(8].)-231.1(Baselin)-11.1(e)-234.5(FEV)]TJ
7.97 0 0 7.97 488.296 615.515 Tm
(1)Tj
9.963 0 0 9.963 494.646 615.515 Tm
[(and)-236(forced)]TJ
-18.6024 -1.0471 TD
[(vita)-8.2(l)-390.1(capaci)-8.6(ty)-396.6(\(FVC\))-396.1(wer)-8.2(e)-393.8(measured)-400.2(until)-397.9(three)-395.6(reprod)-8.2(-)]TJ
0 -1.0527 TD
[(ucibl)-9(e)-325.5(recordings,)-334.2(differing)]TJ
/F8 1 Tf
11.273 0 TD
(<)Tj
/F3 1 Tf
0.552 0 TD
[(5%)-328.3(were)-328.1(obtained.)-330.7(Highe)-10.5(st)]TJ
-11.825 -1.0471 TD
[(values)-356.1(were)-350.8(used)-351.8(for)-352.6(analyses.)-353.9(The)-353.9(subject)-353.5(then)-353(inhaled)]TJ
0 -1.0528 TD
(200)Tj
/F8 1 Tf
1.895 0 TD
(m)Tj
/F3 1 Tf
0.5691 0 TD
[(g)-387.7(salbu)-7.8(tam)-8.2(ol)]TJ
/F4 1 Tf
5.628 0 TD
(via)Tj
/F3 1 Tf
1.599 0 TD
[(a)-388.1(V)120.5(olumatic)-398.5(spacer)-389.8(\(Glax)-12.1(oW)71.3(ell-)]TJ
-9.691 -1.0471 TD
[(come,)-474(Madri)-10.1(d,)-467.8(Spain\))-8.2(.)-467(After)-474.7(15)-473.8(min)-468.8(meas)-8.2(urements)-476.2(of)]TJ
0 -1.0527 TD
(FEV)Tj
7.97 0 0 7.97 328.082 552.756 Tm
(1)Tj
9.963 0 0 9.963 334.998 552.756 Tm
[(wer)-8.2(e)-302.8(repeated.)-308(Ref)-9(erence)-303.7(values)-310.6(were)-305.3(those)-309.4(of)-299(the)]TJ
-2.5778 -1.0471 TD
[(Eur)-8(opean)-334.7(Comm)-8.4(unit)-7.8(y)-330.8(for)-335.5(Coa)-7.4(l)-333.2(and)-338.4(Steel)-338.7([29)]TJ
/F10 1 Tf
11.955 0 0 11.955 491.981 542.324 Tm
(].)Tj
/F4 1 Tf
9.963 0 0 9.963 309.316 521.178 Tm
[(Meth)-8.2(acholi)-9.7(ne)-292.2(and)-298.2(acetal)-10.1(dehyde)-301.7(inhalati)-9.9(on)-291.7(test)-9.4(s.)]TJ
/F3 1 Tf
20.0649 0 TD
[(In)19.6(ha)15.1(la)18.4(-)]TJ
-20.0649 -1.0471 TD
[(ti)16.5(on)-195(pr)14(ov)21.2(oc)15.1(at)18.5(io)18.9(n)-205.6(t)0(e)18.5(s)0(t)17.7(s)-206.8(we)16.9(re)-197(pe)20.8(rf)18(or)13.9(me)17.7(d)-205.6(a)0(c)20.4(c)0(o)15.1(r)0(d)19.6(i)0(n)13.2(g)-199.9(to)-197.4(a)-206(2)0(-)19.6(m)0(i)15.7(n)]TJ
0 -1.0527 TD
[(ti)16.5(da)15.1(l)-310.4(b)0(r)19.6(e)0(a)14.7(t)0(h)18.9(i)0(n)18.8(g)-313.7(me)17.7(th)18.9(od)-303.1(ad)15.1(ap)20.8(te)12.8(d)-308.1(f)0(r)18(o)0(m)-306.3(C)]TJ
6.974 0 0 6.974 463.181 500.258 Tm
0.0001 Tc
[(OCK)21.1(CR)15.2(OF)18.2(T)]TJ
/F4 1 Tf
9.963 0 0 9.963 502.129 500.258 Tm
0 Tc
[(et)-300.2(al)18.9(.)]TJ
/F3 1 Tf
2.3218 0 TD
[([2)19.6(])]TJ
-21.6753 -1.0471 TD
[(for)-460.7(met)-8.2(hachol)-7.8(ine)-460.3(and)-457.9(from)-464.6(M)]TJ
6.974 0 0 6.974 434.551 489.827 Tm
0.0001 Tc
(YOU)Tj
/F4 1 Tf
9.963 0 0 9.963 454.11 489.827 Tm
0 Tc
[(e)-6.9(t)-452.7(al.)]TJ
/F3 1 Tf
2.6461 0 TD
[([14])-461.5(for)-460.7(acet-)]TJ
-17.1798 -1.0015 TD
[(aldehy)-7.8(de.)-480.3(Solutions)-486.7(of)-475.4(methacho)-12.8(line)-474.8(\(Sigm)-10.2(a)-473.5(Che)-7.4(mical)]TJ
T*
[(Co,)-376.5(St.)-379.1(Louis,)-376.1(MO)-7.4(,)-370.3(USA\))-381.6(and)-372.6(acetal)-11(dehyde)-375.3(\(E)-7.2(.)-370.3(Merck)-8.2(,)]TJ
0 -0.9958 TD
[(Dar)-8.2(mstad,)-443.8(Ger)-8.2(many\))-447.1(were)-441.9(prepar)-8.6(ed)-440.1(in)-442.1(a)-445(0.9%)-443.2(sodium)]TJ
0 -1.0015 TD
[(chlor)-8.2(ide)-289.6(solut)-9.8(ion)-289.2(and)-287.2(wer)-8.2(e)-285.7(admi)-9(nistered)-293.3(at)-294.5(room)-292.3(temper-)]TJ
T*
[(ature)-372.8(as)-367.3(aeroso)-8.2(ls)-363.6(generat)-10.5(ed)-366.1(from)-367.9(a)-365.4(starting)-374.9(volume)-369(of)-367.3(2)]TJ
T*
[(mL)-253.5(in)-254.3(a)-251.6(Hudso)-8.9(n)-245.5(1)-6.5(720)-252.7(nebulizer)-259.1(\(Hudson,)-257.1(T)57.7(emecula,)-257.6(CA,)]TJ
0 -0.9958 TD
[(USA)-9.4(\).)-344.2(Nebuliz)-9.1(er)-345(output)-345.1(was)-349.3(0.18\2130.02)-346.4(mL)]TJ
/F5 1 Tf
17.6976 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(min)Tj
7.472 0 0 6.641 503.716 424.516 Tm
(-1)Tj
9.963 0 0 9.963 509.896 420.094 Tm
[(.)-341.8(After)]TJ
-20.1332 -1.0015 TD
[(inhal)-9(ation)-464.2(of)-458.4(0.9%)-466(sodiu)-7.4(m)-459.2(chloride)-468.5(solution)-8.8(,)-455.6(d)0(o)-7.2(ubling)]TJ
T*
[(con)-8.4(centratio)-11.1(ns)-287.2(of)-287.7(0)-6.5(.095\26125)-289.5(mg)]TJ
/F5 1 Tf
12.5021 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 450.312 404.561 Tm
(-1)Tj
9.963 0 0 9.963 459.326 400.138 Tm
[(methach)-12.1(oline)-293.5(or)-287.7(5\261)]TJ
-15.0572 -1.0015 TD
[(40)-269(mg)]TJ
/F5 1 Tf
2.5437 0.2049 TD
(.)Tj
/F3 1 Tf
0.2732 -0.2049 TD
(mL)Tj
7.472 0 0 6.641 351.099 394.639 Tm
(-1)Tj
9.963 0 0 9.963 359.887 390.161 Tm
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[(ma)17.7(li)16.5(ty)-214.5(of)-219.4(di)18.9(st)17.7(ri)17.3(bu)15.5(ti)16.5(on)21.2(s)-223.9(K)0(o)17.3(l)0(m)15.7(o)0(g)15.5(o)0(r)19.6(o)0(v)15.5(-)0(S)20.4(m)0(i)15.7(r)0(n)13.9(o)0(v)-212.1(t)0(e)12.8(s)0(t)-215.7(w)12.4(as)-219.4(us)20(ed)]TJ
0 -1.0471 TD
[(an)15.1(d)-234.1(a)-240.2(p-)19.6(va)15.1(l)13.9(u)0(e)]TJ
/F8 1 Tf
5.48 0 TD
(>)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(05)-229.2(wa)16.9(s)-235.3(o)0(b)15.5(t)0(a)18.4(i)0(n)18.9(e)0(d)15.1(.)-233.7(Th)17.1(us)14.4(,)-233.7(p)0(a)15.1(r)0(a)19.2(m)0(e)17.7(t)0(r)17.3(i)0(c)-231.9(a)0(n)20.8(a)0(l)12.8(y)0(-)]TJ
-6.0263 -1.0527 TD
-0.0169 Tc
[(s)-16.9(e)2.7(s)-252.2(\()-16.9(St)-16.9(ud)-16.9(en)-16.9(ts)]TJ
/F11 1 Tf
5.0817 0 TD
0 Tc
(')Tj
/F3 1 Tf
0.4496 0 TD
[(t-)17.3(te)12.8(st)-221.3(to)-225.8(co)15.1(mp)18.1(ar)19.2(e)-234.5(g)0(r)14(o)0(u)21.2(p)-234.1(me)17.7(an)15.1(s)-235.3(a)0(n)20.8(d)-234.1(Pe)15.9(ar)19.2(so)14.4(n)-234.1(r)]TJ
-5.5312 -1.0471 TD
[(fo)19.6(r)-258.4(c)0(o)15.1(r)0(r)18(e)0(l)18.5(a)0(t)18.4(i)0(o)13.2(n)0(s)20(\))-258.4(we)16.9(re)-248.2(us)20(ed)15.1(.)-256.5(C)0(a)16.1(t)0(e)18.4(g)0(o)15.5(r)0(i)17.3(c)0(a)20.4(l)-259.2(va)20.8(ri)17.3(ab)15.1(le)18.4(s)-258(w)0(e)16.9(r)0(e)-248.2(a)0(n)15.1(-)]TJ
0 -1.0528 TD
[(al)18.4(ys)14.4(ed)-195.4(wi)14.9(th)-197.4(th)13.2(e)-206(F)0(i)13.9(s)0(h)20(e)0(r)]TJ
/F11 1 Tf
8.4448 0 TD
(')Tj
/F3 1 Tf
0.2105 0 TD
[(s)-206.8(e)0(x)15.1(a)0(c)20.4(t)-213.7(te)18.4(st)17.7(.)-205.2(A)0(l)14.9(l)-208(te)18.4(st)17.7(s)-212.5(w)12.4(er)13.5(e)-206(p)0(e)15.1(r)0(f)18(o)0(r)19.6(m)0(e)12(d)]TJ
-8.6553 -1.0471 TD
[(tw)14.9(o-)19.6(si)17.7(de)15.1(d)-456(a)0(n)20.8(d)-456(va)15.1(lu)18.9(es)-447(of)-447(p)]TJ
/F8 1 Tf
10.8633 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(05)-445.4(we)11.2(re)-447.4(co)20.8(ns)20(id)13.2(er)19.2(ed)-445.8(si)17.7(gn)15.5(i-)]TJ
-11.4095 -1.0527 TD
[(fi)17.3(ca)14.7(nt)18.9(.)]TJ
/F7 1 Tf
9.8617 -1.4625 TD
(Results)Tj
/F4 1 Tf
-9.8617 -1.8494 TD
[(Patien)-8.2(t)-333.2(charact)-9.7(eristics)]TJ
/F3 1 Tf
1.0015 -1.5478 TD
[(T)69.1(a)0(b)20.8(l)0(e)-266.1(1)-273.9(shows)-289(the)-283.9(charact)-10.9(eristics)-291.2(of)-287.6(the)-283.9(patien)-10.2(ts.)-284.3(Asth-)]TJ
-1.0015 -1.0528 TD
[(matic)-393.8(subje)-7.8(cts)-387.5(were)-390.7(younger)-394.3(than)-387.1(pa)-7.6(tients)-388.9(with)-393(chroni)-9(c)]TJ
0 -1.0471 TD
[(bronchi)-9.7(tis)-326.9(\(p)]TJ
/F8 1 Tf
5.1158 0 TD
(<)Tj
/F3 1 Tf
0.552 0 TD
[(0.001\),)-330.5(and)-321.4(the)-329.4(percent)-10.5(age)-321.8(o)-6.5(f)-309.7(fema)-8.6(les)-324.9(was)]TJ
-5.6678 -1.0528 TD
[(signifi)-9.6(cantly)-289(great)-8.6(er)-282.4(in)-288.4(the)-283.9(group)-289.9(with)-284.9(asthma)-290.9(than)-290.4(in)-282.7(the)]TJ
0 -1.0471 TD
[(group)-494.8(with)-489.8(c)-6.9(hronic)-492.7(bronchi)-9.7(tis)-491.9(\(p)]TJ
/F8 1 Tf
13.811 0 TD
(<)Tj
/F3 1 Tf
0.552 0 TD
[(0.001\).)-495.6(As)-490.3(expect)-8.2(ed)]TJ
-14.3629 -1.0527 TD
[(\(selec)-11(tion)-292.3(crit)-9.8(eria\),)-300.8(baseline)-297.8(FEV)]TJ
7.97 0 0 7.97 189.751 430.299 Tm
(1)Tj
9.963 0 0 9.963 196.611 430.299 Tm
[(per)-294.5(ce)-8(nt)-294.1(predicted)-304.7(and)]TJ
-13.8849 -1.0471 TD
(FEV)Tj
7.97 0 0 7.97 76.989 419.868 Tm
(1)Tj
9.963 0 0 9.963 80.957 419.868 Tm
[(/FV)-7.8(C)-341.2(percent)-10.5(age)-344.5(were)-345.1(also)-348.5(signifi)-9.6(cantly)-345.9(great)-8.6(er)-345(in)]TJ
-2.2762 -1.0527 TD
[(the)-318.1(asthmati)-12.7(c)-314.2(group)-318.4(than)-318.8(in)-316.9(the)-318.1(chronic)-323.1(bronchiti)-10.3(s)-314.9(group)]TJ
0 -1.0471 TD
(\(p)Tj
/F8 1 Tf
0.8251 0 TD
(<)Tj
/F3 1 Tf
0.552 0 TD
[(0.001\).)-410.2(Mean)-409.8(baseline)-411.6(FEV)]TJ
7.97 0 0 7.97 185.839 398.948 Tm
(1)Tj
9.963 0 0 9.963 193.833 398.948 Tm
[(values)-413(were)-407.7(not)-403(signi)-9.8(-)]TJ
-13.6061 -1.0528 TD
[(fican)-8.6(tly)-405.4(different)-404.2(within)-408.3(the)-409.1(two)-406.9(groups)-405.7(before)-412.6(the)-403.4(tw)-7.8(o)]TJ
0 -1.0471 TD
[(different)-335.9(provoca)-7.7(tion)-337.9(tests)-335.7(\(tabl)-10.6(e)-331.2(1\).)]TJ
/F4 1 Tf
0 -2.1624 TD
[(Airway)-546.6(r)32.2(espons)-7.4(ivenes)-9.4(s)-536.9(t)0(o)-538.8(met)-9(hacholine)-547.3(and)-537.2(acetal)-10.1(de-)]TJ
0 -1.0528 TD
[(hyde)-339.6(in)-334(asthmat)-9.5(ics)-336.3(and)-332.3(c)-6.9(h)0(r)31.4(onic)-335.9(br)25.7(onchitics)]TJ
/F3 1 Tf
1.0015 -1.6503 TD
[(In)19.6(di)13.2(vi)18.9(du)21.2(al)-294.5(re)19.2(su)20(lt)16.5(s)-297.9(o)0(f)-293.3(t)13.9(he)-292.2(tw)14.9(o)-296.7(c)0(h)20.8(a)0(l)12.8(l)0(e)18.4(n)0(g)21.2(e)0(s)-293.3(i)0(n)-288.4(t)0(h)18.9(e)-297.1(tw)14.9(o)-296.7(g)0(r)13.9(o)0(-)]TJ
-1.0015 -1.0471 TD
[(up)15.5(s)-235.3(a)0(r)19.2(e)-240.2(sh)20(ow)17.3(n)-239.8(i)0(n)-225.8(f)0(i)17.3(g)0(u)15.5(r)0(e)-225.5(1)0(.)-240.1(All)-250(subje)-7.8(cts)-251(with)-250.7(asthma)-251.1(show)-8.2(-)]TJ
0 -1.0528 TD
[(ed)-297.8(AHR)-299.4(to)-294.1(met)-8.2(hachol)-7.8(ine)-295.3(but)-294.9(five)-303.3(subjects)-304.3(\(8%\))-298.8(failed)-302(to)]TJ
0 -1.0471 TD
[(respon)-7.8(d)-308.1(t)0(o)-305.5(acetal)-11(dehyde.)-313.1(In)-310.4(the)-306.7(chroni)-9(c)-308.5(bronchi)-9.7(tis)-309.8(group)]TJ
0 -1.0527 TD
[(45)-269(subje)-7.8(cts)-268(\(76%\))-271.1(show)-8.2(ed)-269.4(AHR)-270.9(to)-265.7(met)-8.2(hachol)-7.8(ine,)-267.2(wher)-9(e-)]TJ
0 -1.0471 TD
[(as)-230.7(only)-233.1(three)-230.5(pati)-8.2(ents)-229(\(5%\))-236.2(show)-8.2(ed)-229.6(AHR)-231.1(to)-231.5(acetalde)-12.9(hyde.)]TJ
26.1993 9.1845 TD
[(Al)14.9(th)18.9(ou)15.5(gh)-246.2(se)13.9(ns)20(it)16.5(iv)18.8(it)16.5(y)-256.8(f)0(o)19.6(r)-258.4(ac)14.7(et)18.4(al)18.5(de)15.1(hy)21.2(de)-252.3(\(9)19.6(2%)13.2(\))-252.8(w)0(a)16.9(s)-258(a)-257.2(l)0(i)16.5(t)0(t)16.5(l)0(e)]TJ
-1.0015 -1.0755 TD
[(le)12.8(ss)-385.2(th)18.9(an)-388.9(fo)19.6(r)-400.7(m)0(e)17.7(t)0(h)18.9(a)0(c)14.7(h)0(o)21.2(l)0(i)16.5(n)0(e)-388.9(\()0(1)19.6(0)0(0)15.5(%)0(\))-386.7(i)0(n)-390.9(r)0(e)19.2(v)0(e)15.1(a)0(l)18.4(i)0(n)18.8(g)-399.1(A)12.4(H)0(R)-391.4(i)0(n)]TJ
T*
[(as)13.9(th)18.9(ma)17.7(,)-575.1(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(o)0(p)15.5(r)0(o)19.6(v)0(o)15.5(c)0(a)14.7(t)13.9(io)13.2(n)-569.8(w)0(i)14.9(t)0(h)-567.3(a)0(c)20.4(e)0(t)12.8(a)0(l)18.5(d)0(e)20.8(h)0(y)15.5(d)0(e)-565.3(y)0(i)18.9(e)0(l)18.5(d)0(e)15.1(d)]TJ
T*
[(co)15.1(ns)20(id)13.2(er)19.2(ab)20.8(ly)-436.4(gr)13.9(ea)20.4(te)12.8(r)-440.5(s)0(p)14.4(e)0(c)20.4(i)0(f)17.3(i)0(c)12.8(i)0(t)16.5(y)-444.6(\(9)19.6(5%)18.9(\))-446.2(t)0(h)18.9(a)0(n)-440.1(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(o)0(p)15.5(r)0(o)19.6(-)]TJ
T*
[(vo)15.5(ca)14.7(t)13.9(i)0(o)13.2(n)-421.9(wi)14.9(th)-413.6(me)12(th)18.9(ac)20.4(ho)15.5(li)16.5(ne)-417.3(\(2)19.6(4%)13.2(\))-423.5(i)0(n)-413.6(s)0(e)13.9(p)0(a)20.8(r)0(a)13.5(t)0(i)16.5(n)0(g)-411.3(a)0(s)14(t)0(h)18.9(m)0(a)]TJ
T*
[(fr)12.4(om)-488.4(ch)20.8(ro)19.6(ni)13.2(c)-496.3(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(i)0(t)16.5(i)0(s)17.7(.)-495.5(Th)17.1(er)19.2(ef)13.5(or)19.6(e,)-485.2(br)13.9(on)21.2(ch)15.1(op)21.2(ro)13.9(vo)21.2(ca)14.7(ti)16.5(on)]TJ
T*
[(wi)14.9(th)-493.3(ac)20.4(et)18.5(al)12.8(de)20.8(hy)15.5(de)-485.6(wa)11.2(s)-497(a)-496.3(mo)12.4(re)-487.2(ac)14.7(cu)20.8(ra)13.5(te)-488(di)18.8(ag)15.1(no)15.5(st)17.7(ic)-488(te)18.4(st)]TJ
T*
-0.017 Tc
[(\()-17(9)-3.1(3)-17(%)1.9(\))-309.6(t)-17(ha)-17(n)-297.8(b)-17(ro)-17(nc)-17(h)3.8(o)-17(pr)-17(ov)-17(oc)-17(at)-17(io)-17(n)-297.4(w)-17(it)-17(h)-294.1(m)-17(et)-17(ha)-17(ch)-17(ol)-17(in)-17(e)-292.1(\()-17(60)-17(%\))]TJ
0 -1.0698 TD
0 Tc
[(to)-316.9(di)18.9(f)14.7(f)0(e)19.2(r)0(e)19.2(n)0(t)13.2(i)13.9(at)12.8(e)-319.8(a)0(s)13.9(t)0(h)18.9(m)0(a)-318.1(a)0(n)20.8(d)-325.1(ch)15.1(ro)19.6(ni)18.9(c)-325.5(b)0(r)13.9(o)0(n)21.2(c)0(h)15.1(i)0(t)22.2(i)0(s)12(.)]TJ
1.0015 -1.0528 TD
[(Th)17.1(e)-336.9(g)0(e)15.1(o)0(m)18.1(e)0(t)18.4(r)0(i)17.3(c)-336.9(me)17.7(an)-326.3(PC)]TJ
7.97 0 0 7.97 416.183 272.636 Tm
(20)Tj
9.963 0 0 9.963 427.408 272.636 Tm
[(me)17.7(th)13.2(ac)20.4(ho)15.5(li)16.5(ne)-326.3(in)-322.6(th)13.2(e)-331.2(a)0(s)14(t)0(h)18.9(m)0(a)]TJ
-11.8534 -1.0755 TD
[(gr)13.9(ou)21.2(p)-313.8(\()0(0)19.6(.)0(2)15.9(9)-308.1(mg)]TJ
/F5 1 Tf
6.197 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 387.269 266.343 Tm
(-1)Tj
9.963 0 0 9.963 393.222 261.921 Tm
[(\))-315.3(w)12.4(as)-304.7(si)17.7(gn)21.2(if)17.3(ic)12.8(an)20.8(tl)16.5(y)-308.1(l)0(o)13.2(w)12.4(er)-305.1(th)18.9(an)-303.5(in)-299.8(th)18.9(e)]TJ
-8.422 -1.0755 TD
[(ch)15.1(ro)19.6(ni)13.2(c)-308.5(b)0(r)14(o)0(n)21.2(c)0(h)15.1(i)0(t)16.5(i)0(s)-301(g)0(r)14(o)0(u)21.2(p)-313.8(\(2)19.6(.0)15.9(9,)-302.7(p)]TJ
/F8 1 Tf
13.094 0 TD
(<)Tj
/F3 1 Tf
0.5406 0 TD
[(0.)15.9(00)15.5(1\))19.6(.)-313.4(D)12.4(es)13.9(pi)18.9(te)-305.9(th)18.8(e)-314.2(o)0(b)21.2(-)]TJ
-13.6346 -1.0698 TD
[(se)13.9(rv)19.6(ed)-297.8(di)13.2(f)20.4(f)0(e)19.2(r)0(e)13.5(n)0(c)20.8(e)0(s)-299(i)0(n)-299.8(P)0(C)]TJ
7.97 0 0 7.97 405.921 240.548 Tm
(20)Tj
9.963 0 0 9.963 416.863 240.548 Tm
[(va)15.1(lu)18.8(es)13.9(,)-307.7(t)13.9(he)15.1(re)-299.4(wa)16.9(s)-309.2(c)0(o)15.1(n)0(s)20(i)0(d)18.9(e)0(r)13.5(a)0(b)20.8(l)0(e)]TJ
-10.795 -1.0755 TD
[(ov)15.5(er)19.2(la)12.8(p)-291(i)0(n)-288.4(i)0(n)18.9(d)0(i)13.2(v)0(i)18.9(d)0(u)21.2(a)0(l)-288.8(P)0(C)]TJ
7.97 0 0 7.97 405.978 229.833 Tm
(20)Tj
9.963 0 0 9.963 416.806 229.833 Tm
[(le)18.4(ve)15.1(ls)-289.6(be)20.8(tw)14.9(ee)20.4(n)-296.7(t)0(h)13.2(e)-291.4(tw)14.9(o)-296.7(g)0(r)19.6(o)0(u)15.5(p)0(s)]TJ
-10.7893 -1.0755 TD
[(\(f)12.4(ig)18.8(.)-324.7(1\).)]TJ
1.0015 -1.0528 TD
[(In)-230.7(th)18.8(e)-234.5(c)0(h)15.1(r)0(o)19.6(n)0(i)13.2(c)-234.5(br)19.6(on)15.5(ch)20.8(it)16.5(is)-227(gr)13.9(ou)21.2(p)-239.8(5)0(6)-223.5(o)0(f)-230.7(t)13.9(he)-229.6(59)-229.1(su)20(bj)18.9(ec)14.7(ts)-227(di)18.8(d)]TJ
-1.0015 -1.0755 TD
[(no)15.5(t)-304.7(r)0(e)19.2(s)0(p)20(o)0(n)15.5(d)-302.4(to)-294.1(th)18.9(e)-302.8(h)0(i)18.9(g)0(h)21.2(e)0(s)13.9(t)-299.1(ac)14.7(et)18.4(al)18.5(de)15.1(hy)21.2(de)-297.8(co)20.8(nc)15.1(en)20.8(tr)17.3(at)12.8(i)13.9(o)0(n)-297.4(a)0(d)20.8(-)]TJ
0 -1.0698 TD
[(mi)15.7(ni)13.2(st)17.7(er)19.2(ed)-497(an)20.8(d)-507.2(t)0(h)18.9(i)0(s)-494.5(p)0(r)19.6(e)0(c)14.7(l)0(u)18.9(d)0(e)15.1(d)-501.5(co)15.1(mp)18.1(ar)19.2(is)17.7(on)-496.6(of)-498.2(t)13.9(h)0(e)-497(P)0(C)]TJ
7.97 0 0 7.97 528.605 187.257 Tm
(20)Tj
9.963 0 0 9.963 309.316 176.542 Tm
[(ac)14.7(et)18.5(al)18.4(de)15.1(hy)21.2(de)-218.2(be)20.8(tw)14.9(ee)20.4(n)-222.7(a)0(s)19.6(t)0(h)13.2(m)0(a)17.7(t)0(i)16.5(c)0(s)-213.7(a)0(n)20.8(d)-222.7(pa)15.1(t)13.9(i)0(e)12.8(n)0(t)18.9(s)-218.2(wi)14.9(th)-214.5(ch)20.8(ro)13.9(ni)18.8(c)]TJ
0 -1.0755 TD
[(br)13.9(on)21.2(ch)15.1(it)16.5(is)17.7(.)]TJ
1.0015 -1.0528 TD
(PC)Tj
7.97 0 0 7.97 331.313 155.339 Tm
-0.0163 Tc
(20)Tj
9.963 0 0 9.963 342.482 155.339 Tm
0 Tc
[(me)17.7(th)13.2(ac)20.4(ho)15.5(li)16.5(ne)-320.6(an)15.1(d)-330.8(P)0(C)]TJ
7.97 0 0 7.97 427.408 155.339 Tm
-0.0163 Tc
(20)Tj
9.963 0 0 9.963 438.576 155.339 Tm
0 Tc
[(ac)14.7(et)18.4(al)18.5(de)15.1(hy)21.2(de)-326.3(we)16.9(re)-327.9(si)17.7(gn)21.2(i-)]TJ
-12.9744 -1.0755 TD
[(fi)17.3(ca)14.7(nt)18.9(ly)-288.4(co)15.1(rr)18(el)18.4(at)18.5(ed)-286.5(in)-288.4(th)18.9(e)-297.1(a)0(s)19.6(t)0(h)13.2(m)0(a)-283.9(g)0(r)13.9(o)0(u)21.2(p)-296.7(\(r)]TJ
/F8 1 Tf
16.1953 0 TD
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(42)15.5(,)-296.3(p)]TJ
/F8 1 Tf
2.7485 0 TD
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(00)15.5(1\))19.6(.)]TJ
-20.0364 -1.0698 TD
[(Si)13.9(de)-343.4(ef)24.9(fe)19.2(ct)18.4(s)-354.8(a)0(f)13.5(t)13.9(er)-350.7(in)18.8(ha)20.8(la)12.8(ti)22.2(on)-348.7(of)-344.6(ac)14.7(et)18.5(al)18.4(de)20.8(hy)15.5(de)-343.4(we)16.9(re)-350.7(co)20.8(ug)15.5(h,)]TJ
0 -1.0755 TD
[(ch)15.1(es)19.6(t)-429.9(t)0(i)16.5(g)0(h)15.5(t)0(n)18.9(e)0(s)19.6(s)0(,)-423.4(a)0(n)15.1(d)-427.6(ph)21.2(ar)13.5(yn)21.2(ge)15.1(al)-419.7(ir)17.3(ri)17.3(ta)12.8(ti)22.2(on)15.5(.)-427.2(N)0(o)-426.6(o)0(t)18.9(h)0(e)20.8(r)-434.8(si)17.7(de)]TJ
T*
[(ef)24.9(fe)19.2(ct)12.8(s)-320.6(w)0(e)16.9(r)0(e)-316.5(d)0(o)15.5(c)0(u)20.8(m)0(e)17.7(n)0(t)13.2(e)0(d)20.8(.)]TJ
ET
1 i 
58.28 253.474 227.168 -0.51 re
f
58.28 237.033 227.168 -0.51 re
f
58.28 144.907 227.168 -0.51 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 257.839 Tm
[(Table)-331.9(1.)-336.7(\261)-333.2(Subject)-333.5(characteristics)]TJ
/F3 1 Tf
11.7037 -1.7072 TD
[(Asthma)-2743.3(Chronic)-339.4(bronchitis)]TJ
-11.7037 -1.998 TD
12.247 Tc
[(n6)12247(2)5223.2(5)12247(9)]TJ
0 -1.0559 TD
0 Tc
[(Age)-336.7(yrs)-9029.8(31\2131)-5982.7(56\2131)]TJ
T*
[(Per)-332.9(cent)-335(male)-7209.9(39)-7023.8(88)]TJ
T*
[(Pack-years)-8759.2(-)-6095.8(51.1\2133.4)]TJ
T*
(FEV)Tj
7.173 0 0 7.173 75.118 186.746 Tm
(1)Tj
8.966 0 0 8.966 81.638 186.746 Tm
[(%)-335.1(predicted)-4040.8(97.4\2131.4)-4489(83.2\2132.0)]TJ
-2.605 -1.0559 TD
(FEV)Tj
7.173 0 0 7.173 75.118 177.279 Tm
(1)Tj
8.966 0 0 8.966 78.69 177.279 Tm
[(/FVC)-335.7(%)-5836(78.2\2131.0)-4489(69.0\2131.2)]TJ
-2.2762 -1.0559 TD
[(Prechallenge)-338.5(FEV)]TJ
7.173 0 0 7.173 123.817 167.811 Tm
(1)Tj
8.966 0 0 8.966 130.394 167.811 Tm
(L)Tj
-7.7076 -1.0559 TD
[(Methacholine)-5463.8(3.39\2130.1)31.9(1)-4001.9(2.45\2130.07)]TJ
T*
[(Acetaldehyde)-5451.1(3.33\2130.10)-3982.6(2.42\2130.07)]TJ
-0.3351 -1.9475 TD
[(Data)-325.7(are)-327.8(presented)-328.1(as)-322.4(absolute)-323.9(numbers)-329(and)-327.1(mean\213)]TJ
6.276 0 0 6.276 244.63 131.414 Tm
0.0001 Tc
(SEM)Tj
8.966 0 0 8.966 257.442 131.414 Tm
0 Tc
[(.)-325.4(FEV)]TJ
7.173 0 0 7.173 279.439 131.414 Tm
(1)Tj
8.966 0 0 8.966 283.011 131.414 Tm
(:)Tj
-25.064 -1.0496 TD
[(forced)-320.9(expiratory)-317.3(volume)-323.4(in)-317.5(one)-314.4(second;)-322(FVC:)-316.8(forced)-320.9(vital)-320.5(ca-)]TJ
0 -1.0559 TD
[(pacity)62(.)]TJ
/F16 1 Tf
10 0 0 10 327.904 638.915 Tm
0 0 0 1 k
/GS3 gs
(0.01)Tj
0 10 -10 0 320.904 656.631 Tm
(PC)Tj
0 8 -8 0 320.904 668.021 Tm
(20)Tj
0 10 -10 0 320.904 675.317 Tm
( methacholine  mg\341mL)Tj
0 8 -8 0 318.636 755.987 Tm
(-1)Tj
ET
0 0 0 1 K
0 J 0 j 0.5 w 3.864 M []0 d
/GS4 gs
350.904 641.631 m
350.904 772.13 l
346.904 772.13 m
350.904 772.13 l
S
BT
10 0 0 10 329.904 769.481 Tm
/GS3 gs
(100)Tj
ET
/GS4 gs
346.904 739.131 m
350.904 739.131 l
S
BT
10 0 0 10 329.904 736.481 Tm
/GS3 gs
(  10)Tj
ET
/GS4 gs
346.904 706.414 m
350.904 706.414 l
S
BT
10 0 0 10 330.471 703.765 Tm
/GS3 gs
(    1)Tj
ET
/GS4 gs
346.904 673.698 m
350.904 673.698 l
S
BT
10 0 0 10 330.471 671.049 Tm
/GS3 gs
( 0.1)Tj
ET
/GS4 gs
346.904 641.549 m
533.903 641.549 l
S
BT
10 0 0 10 312.904 769.63 Tm
/GS3 gs
(a\))Tj
ET
[4 4 ]0 d
/GS4 gs
350.904 748.198 m
534.505 748.198 l
391.403 641.631 m
391.403 638.631 l
493.903 641.631 m
493.903 638.348 l
S
[]0 d
380.362 692.816 m
380.362 693.42 380.852 693.91 381.456 693.91 c
382.06 693.91 382.55 693.42 382.55 692.816 c
382.55 692.212 382.06 691.723 381.456 691.723 c
380.852 691.723 380.362 692.212 380.362 692.816 c
b
386.536 692.904 m
386.536 693.509 387.025 693.999 387.63 693.999 c
388.234 693.999 388.723 693.509 388.723 692.904 c
388.723 692.3 388.234 691.811 387.63 691.811 c
387.025 691.811 386.536 692.3 386.536 692.904 c
b
389.536 695.947 m
389.536 696.551 390.026 697.041 390.63 697.041 c
391.234 697.041 391.724 696.551 391.724 695.947 c
391.724 695.343 391.234 694.854 390.63 694.854 c
390.026 694.854 389.536 695.343 389.536 695.947 c
b
389.536 699.251 m
389.536 699.855 390.026 700.345 390.63 700.345 c
391.234 700.345 391.724 699.855 391.724 699.251 c
391.724 698.647 391.234 698.157 390.63 698.157 c
390.026 698.157 389.536 698.647 389.536 699.251 c
b
383.493 699.12 m
383.493 699.724 383.983 700.214 384.587 700.214 c
385.191 700.214 385.681 699.724 385.681 699.12 c
385.681 698.516 385.191 698.027 384.587 698.027 c
383.983 698.027 383.493 698.516 383.493 699.12 c
b
386.405 702.251 m
386.405 702.856 386.895 703.345 387.499 703.345 c
388.103 703.345 388.593 702.856 388.593 702.251 c
388.593 701.647 388.103 701.158 387.499 701.158 c
386.895 701.158 386.405 701.647 386.405 702.251 c
b
386.405 705.425 m
386.405 706.029 386.895 706.518 387.499 706.518 c
388.103 706.518 388.593 706.029 388.593 705.425 c
388.593 704.821 388.103 704.331 387.499 704.331 c
386.895 704.331 386.405 704.821 386.405 705.425 c
b
383.232 711.686 m
383.232 712.291 383.722 712.78 384.326 712.78 c
384.93 712.78 385.42 712.291 385.42 711.686 c
385.42 711.082 384.93 710.593 384.326 710.593 c
383.722 710.593 383.232 711.082 383.232 711.686 c
b
389.667 708.425 m
389.667 709.029 390.156 709.519 390.76 709.519 c
391.365 709.519 391.854 709.029 391.854 708.425 c
391.854 707.821 391.365 707.331 390.76 707.331 c
390.156 707.331 389.667 707.821 389.667 708.425 c
b
386.536 658.86 m
386.536 659.464 387.025 659.954 387.63 659.954 c
388.234 659.954 388.723 659.464 388.723 658.86 c
388.723 658.256 388.234 657.766 387.63 657.766 c
387.025 657.766 386.536 658.256 386.536 658.86 c
b
395.71 668.295 m
395.71 668.899 396.199 669.388 396.804 669.388 c
397.408 669.388 397.897 668.899 397.897 668.295 c
397.897 667.691 397.408 667.201 396.804 667.201 c
396.199 667.201 395.71 667.691 395.71 668.295 c
b
395.71 671.426 m
395.71 672.03 396.199 672.519 396.804 672.519 c
397.408 672.519 397.897 672.03 397.897 671.426 c
397.897 670.822 397.408 670.332 396.804 670.332 c
396.199 670.332 395.71 670.822 395.71 671.426 c
b
398.71 677.599 m
398.71 678.203 399.2 678.693 399.804 678.693 c
400.408 678.693 400.898 678.203 400.898 677.599 c
400.898 676.995 400.408 676.505 399.804 676.505 c
399.2 676.505 398.71 676.995 398.71 677.599 c
b
398.841 680.73 m
398.841 681.334 399.331 681.824 399.935 681.824 c
400.539 681.824 401.028 681.334 401.028 680.73 c
401.028 680.126 400.539 679.636 399.935 679.636 c
399.331 679.636 398.841 680.126 398.841 680.73 c
b
398.841 683.642 m
398.841 684.246 399.331 684.736 399.935 684.736 c
400.539 684.736 401.028 684.246 401.028 683.642 c
401.028 683.038 400.539 682.549 399.935 682.549 c
399.331 682.549 398.841 683.038 398.841 683.642 c
b
398.71 686.643 m
398.71 687.247 399.2 687.737 399.804 687.737 c
400.408 687.737 400.898 687.247 400.898 686.643 c
400.898 686.039 400.408 685.549 399.804 685.549 c
399.2 685.549 398.71 686.039 398.71 686.643 c
b
398.841 689.816 m
398.841 690.42 399.331 690.91 399.935 690.91 c
400.539 690.91 401.028 690.42 401.028 689.816 c
401.028 689.212 400.539 688.722 399.935 688.722 c
399.331 688.722 398.841 689.212 398.841 689.816 c
b
395.58 677.469 m
395.58 678.073 396.069 678.562 396.673 678.562 c
397.277 678.562 397.767 678.073 397.767 677.469 c
397.767 676.865 397.277 676.375 396.673 676.375 c
396.069 676.375 395.58 676.865 395.58 677.469 c
b
395.71 680.6 m
395.71 681.204 396.199 681.693 396.804 681.693 c
397.408 681.693 397.897 681.204 397.897 680.6 c
397.897 679.996 397.408 679.506 396.804 679.506 c
396.199 679.506 395.71 679.996 395.71 680.6 c
b
395.71 683.642 m
395.71 684.246 396.199 684.736 396.804 684.736 c
397.408 684.736 397.897 684.246 397.897 683.642 c
397.897 683.038 397.408 682.549 396.804 682.549 c
396.199 682.549 395.71 683.038 395.71 683.642 c
b
395.71 692.947 m
395.71 693.551 396.199 694.041 396.804 694.041 c
397.408 694.041 397.897 693.551 397.897 692.947 c
397.897 692.343 397.408 691.853 396.804 691.853 c
396.199 691.853 395.71 692.343 395.71 692.947 c
b
395.71 699.12 m
395.71 699.725 396.199 700.214 396.804 700.214 c
397.408 700.214 397.897 699.725 397.897 699.12 c
397.897 698.516 397.408 698.027 396.804 698.027 c
396.199 698.027 395.71 698.516 395.71 699.12 c
b
0 0 0 0 k
383.295 708.153 m
383.295 708.757 383.784 709.247 384.388 709.247 c
384.993 709.247 385.482 708.757 385.482 708.153 c
385.482 707.549 384.993 707.06 384.388 707.06 c
383.784 707.06 383.295 707.549 383.295 708.153 c
b
386.468 711.633 m
386.468 712.237 386.958 712.727 387.562 712.727 c
388.166 712.727 388.655 712.237 388.655 711.633 c
388.655 711.029 388.166 710.54 387.562 710.54 c
386.958 710.54 386.468 711.029 386.468 711.633 c
b
398.773 674.415 m
398.773 675.019 399.263 675.509 399.867 675.509 c
400.471 675.509 400.96 675.019 400.96 674.415 c
400.96 673.811 400.471 673.322 399.867 673.322 c
399.263 673.322 398.773 673.811 398.773 674.415 c
b
0 0 0 1 k
392.69 661.818 m
392.69 662.422 393.18 662.912 393.784 662.912 c
394.388 662.912 394.877 662.422 394.877 661.818 c
394.877 661.214 394.388 660.724 393.784 660.724 c
393.18 660.724 392.69 661.214 392.69 661.818 c
b
392.69 674.296 m
392.69 674.9 393.18 675.389 393.784 675.389 c
394.388 675.389 394.877 674.9 394.877 674.296 c
394.877 673.692 394.388 673.202 393.784 673.202 c
393.18 673.202 392.69 673.692 392.69 674.296 c
b
392.69 680.469 m
392.69 681.073 393.18 681.563 393.784 681.563 c
394.388 681.563 394.877 681.073 394.877 680.469 c
394.877 679.865 394.388 679.376 393.784 679.376 c
393.18 679.376 392.69 679.865 392.69 680.469 c
b
392.69 683.6 m
392.69 684.204 393.18 684.694 393.784 684.694 c
394.388 684.694 394.877 684.204 394.877 683.6 c
394.877 682.996 394.388 682.506 393.784 682.506 c
393.18 682.506 392.69 682.996 392.69 683.6 c
b
392.69 692.904 m
392.69 693.509 393.18 693.999 393.784 693.999 c
394.388 693.999 394.877 693.509 394.877 692.904 c
394.877 692.3 394.388 691.811 393.784 691.811 c
393.18 691.811 392.69 692.3 392.69 692.904 c
b
392.69 702.251 m
392.69 702.856 393.18 703.345 393.784 703.345 c
394.388 703.345 394.877 702.856 394.877 702.251 c
394.877 701.647 394.388 701.158 393.784 701.158 c
393.18 701.158 392.69 701.647 392.69 702.251 c
b
392.69 705.425 m
392.69 706.029 393.18 706.518 393.784 706.518 c
394.388 706.518 394.877 706.029 394.877 705.425 c
394.877 704.821 394.388 704.331 393.784 704.331 c
393.18 704.331 392.69 704.821 392.69 705.425 c
b
392.69 711.644 m
392.69 712.248 393.18 712.738 393.784 712.738 c
394.388 712.738 394.877 712.248 394.877 711.644 c
394.877 711.04 394.388 710.551 393.784 710.551 c
393.18 710.551 392.69 711.04 392.69 711.644 c
b
0 0 0 0 k
392.622 686.72 m
392.622 687.324 393.112 687.814 393.716 687.814 c
394.32 687.814 394.809 687.324 394.809 686.72 c
394.809 686.116 394.32 685.627 393.716 685.627 c
393.112 685.627 392.622 686.116 392.622 686.72 c
b
392.622 695.936 m
392.622 696.541 393.112 697.03 393.716 697.03 c
394.32 697.03 394.809 696.541 394.809 695.936 c
394.809 695.332 394.32 694.843 393.716 694.843 c
393.112 694.843 392.622 695.332 392.622 695.936 c
b
0 0 0 1 k
392.648 714.729 m
392.648 715.333 393.137 715.823 393.741 715.823 c
394.346 715.823 394.835 715.333 394.835 714.729 c
394.835 714.125 394.346 713.635 393.741 713.635 c
393.137 713.635 392.648 714.125 392.648 714.729 c
b
392.667 717.86 m
392.667 718.464 393.157 718.954 393.761 718.954 c
394.365 718.954 394.855 718.464 394.855 717.86 c
394.855 717.256 394.365 716.766 393.761 716.766 c
393.157 716.766 392.667 717.256 392.667 717.86 c
b
395.561 705.381 m
395.561 705.985 396.051 706.475 396.655 706.475 c
397.259 706.475 397.748 705.985 397.748 705.381 c
397.748 704.777 397.259 704.288 396.655 704.288 c
396.051 704.288 395.561 704.777 395.561 705.381 c
b
395.58 708.512 m
395.58 709.116 396.07 709.606 396.674 709.606 c
397.278 709.606 397.768 709.116 397.768 708.512 c
397.768 707.908 397.278 707.418 396.674 707.418 c
396.07 707.418 395.58 707.908 395.58 708.512 c
b
383.624 683.642 m
383.624 684.246 384.113 684.736 384.717 684.736 c
385.321 684.736 385.811 684.246 385.811 683.642 c
385.811 683.038 385.321 682.549 384.717 682.549 c
384.113 682.549 383.624 683.038 383.624 683.642 c
b
386.536 680.427 m
386.536 681.031 387.025 681.521 387.63 681.521 c
388.234 681.521 388.723 681.031 388.723 680.427 c
388.723 679.823 388.234 679.333 387.63 679.333 c
387.025 679.333 386.536 679.823 386.536 680.427 c
b
386.405 686.773 m
386.405 687.377 386.895 687.867 387.499 687.867 c
388.103 687.867 388.593 687.377 388.593 686.773 c
388.593 686.169 388.103 685.68 387.499 685.68 c
386.895 685.68 386.405 686.169 386.405 686.773 c
b
380.362 689.816 m
380.362 690.42 380.852 690.91 381.456 690.91 c
382.06 690.91 382.55 690.42 382.55 689.816 c
382.55 689.212 382.06 688.722 381.456 688.722 c
380.852 688.722 380.362 689.212 380.362 689.816 c
b
383.493 689.816 m
383.493 690.42 383.983 690.91 384.587 690.91 c
385.191 690.91 385.681 690.42 385.681 689.816 c
385.681 689.212 385.191 688.722 384.587 688.722 c
383.983 688.722 383.493 689.212 383.493 689.816 c
b
389.667 655.556 m
389.667 656.16 390.156 656.65 390.76 656.65 c
391.365 656.65 391.854 656.16 391.854 655.556 c
391.854 654.952 391.365 654.462 390.76 654.462 c
390.156 654.462 389.667 654.952 389.667 655.556 c
b
389.667 658.86 m
389.667 659.464 390.156 659.954 390.76 659.954 c
391.365 659.954 391.854 659.464 391.854 658.86 c
391.854 658.256 391.365 657.766 390.76 657.766 c
390.156 657.766 389.667 658.256 389.667 658.86 c
b
386.405 671.295 m
386.405 671.899 386.895 672.389 387.499 672.389 c
388.103 672.389 388.593 671.899 388.593 671.295 c
388.593 670.691 388.103 670.201 387.499 670.201 c
386.895 670.201 386.405 670.691 386.405 671.295 c
b
389.536 668.164 m
389.536 668.768 390.026 669.258 390.63 669.258 c
391.234 669.258 391.724 668.768 391.724 668.164 c
391.724 667.56 391.234 667.07 390.63 667.07 c
390.026 667.07 389.536 667.56 389.536 668.164 c
b
389.667 671.295 m
389.667 671.899 390.156 672.389 390.76 672.389 c
391.365 672.389 391.854 671.899 391.854 671.295 c
391.854 670.691 391.365 670.201 390.76 670.201 c
390.156 670.201 389.667 670.691 389.667 671.295 c
b
389.667 674.338 m
389.667 674.942 390.156 675.432 390.76 675.432 c
391.365 675.432 391.854 674.942 391.854 674.338 c
391.854 673.734 391.365 673.244 390.76 673.244 c
390.156 673.244 389.667 673.734 389.667 674.338 c
b
389.667 677.469 m
389.667 678.073 390.156 678.562 390.76 678.562 c
391.365 678.562 391.854 678.073 391.854 677.469 c
391.854 676.865 391.365 676.375 390.76 676.375 c
390.156 676.375 389.667 676.865 389.667 677.469 c
b
389.667 683.6 m
389.667 684.204 390.156 684.694 390.76 684.694 c
391.365 684.694 391.854 684.204 391.854 683.6 c
391.854 682.996 391.365 682.506 390.76 682.506 c
390.156 682.506 389.667 682.996 389.667 683.6 c
b
389.667 689.946 m
389.667 690.55 390.156 691.04 390.76 691.04 c
391.365 691.04 391.854 690.55 391.854 689.946 c
391.854 689.342 391.365 688.853 390.76 688.853 c
390.156 688.853 389.667 689.342 389.667 689.946 c
b
488.578 690.687 m
488.578 691.291 489.068 691.781 489.672 691.781 c
490.276 691.781 490.766 691.291 490.766 690.687 c
490.766 690.083 490.276 689.593 489.672 689.593 c
489.068 689.593 488.578 690.083 488.578 690.687 c
b
485.536 709.035 m
485.536 709.639 486.025 710.129 486.63 710.129 c
487.234 710.129 487.723 709.639 487.723 709.035 c
487.723 708.431 487.234 707.941 486.63 707.941 c
486.025 707.941 485.536 708.431 485.536 709.035 c
b
497.622 721.685 m
497.622 722.289 498.112 722.779 498.716 722.779 c
499.32 722.779 499.81 722.289 499.81 721.685 c
499.81 721.081 499.32 720.591 498.716 720.591 c
498.112 720.591 497.622 721.081 497.622 721.685 c
b
386.536 674.338 m
386.536 674.942 387.025 675.432 387.63 675.432 c
388.234 675.432 388.723 674.942 388.723 674.338 c
388.723 673.734 388.234 673.244 387.63 673.244 c
387.025 673.244 386.536 673.734 386.536 674.338 c
b
383.493 674.296 m
383.493 674.9 383.983 675.389 384.587 675.389 c
385.191 675.389 385.681 674.9 385.681 674.296 c
385.681 673.692 385.191 673.202 384.587 673.202 c
383.983 673.202 383.493 673.692 383.493 674.296 c
b
383.363 677.469 m
383.363 678.073 383.852 678.562 384.457 678.562 c
385.061 678.562 385.55 678.073 385.55 677.469 c
385.55 676.865 385.061 676.375 384.457 676.375 c
383.852 676.375 383.363 676.865 383.363 677.469 c
b
386.536 677.557 m
386.536 678.161 387.025 678.651 387.63 678.651 c
388.234 678.651 388.723 678.161 388.723 677.557 c
388.723 676.953 388.234 676.463 387.63 676.463 c
387.025 676.463 386.536 676.953 386.536 677.557 c
b
380.493 671.122 m
380.493 671.727 380.982 672.216 381.586 672.216 c
382.19 672.216 382.68 671.727 382.68 671.122 c
382.68 670.518 382.19 670.029 381.586 670.029 c
380.982 670.029 380.493 670.518 380.493 671.122 c
b
377.189 677.338 m
377.189 677.942 377.679 678.432 378.283 678.432 c
378.887 678.432 379.377 677.942 379.377 677.338 c
379.377 676.734 378.887 676.245 378.283 676.245 c
377.679 676.245 377.189 676.734 377.189 677.338 c
b
377.231 680.469 m
377.231 681.073 377.721 681.563 378.325 681.563 c
378.929 681.563 379.419 681.073 379.419 680.469 c
379.419 679.865 378.929 679.376 378.325 679.376 c
377.721 679.376 377.231 679.865 377.231 680.469 c
b
380.362 680.339 m
380.362 680.943 380.852 681.432 381.456 681.432 c
382.06 681.432 382.55 680.943 382.55 680.339 c
382.55 679.735 382.06 679.245 381.456 679.245 c
380.852 679.245 380.362 679.735 380.362 680.339 c
b
380.362 683.512 m
380.362 684.116 380.852 684.605 381.456 684.605 c
382.06 684.605 382.55 684.116 382.55 683.512 c
382.55 682.908 382.06 682.418 381.456 682.418 c
380.852 682.418 380.362 682.908 380.362 683.512 c
b
0 0 0 0 k
491.642 681.371 m
491.642 681.975 492.131 682.465 492.735 682.465 c
493.339 682.465 493.829 681.975 493.829 681.371 c
493.829 680.767 493.339 680.278 492.735 680.278 c
492.131 680.278 491.642 680.767 491.642 681.371 c
b
491.772 684.284 m
491.772 684.888 492.261 685.378 492.866 685.378 c
493.47 685.378 493.959 684.888 493.959 684.284 c
493.959 683.679 493.47 683.19 492.866 683.19 c
492.261 683.19 491.772 683.679 491.772 684.284 c
b
506.859 752.98 m
506.859 753.584 507.348 754.074 507.952 754.074 c
508.556 754.074 509.046 753.584 509.046 752.98 c
509.046 752.376 508.556 751.886 507.952 751.886 c
507.348 751.886 506.859 752.376 506.859 752.98 c
b
500.685 753.022 m
500.685 753.626 501.175 754.116 501.779 754.116 c
502.383 754.116 502.873 753.626 502.873 753.022 c
502.873 752.418 502.383 751.928 501.779 751.928 c
501.175 751.928 500.685 752.418 500.685 753.022 c
b
494.511 752.892 m
494.511 753.496 495.001 753.985 495.605 753.985 c
496.209 753.985 496.699 753.496 496.699 752.892 c
496.699 752.288 496.209 751.798 495.605 751.798 c
495.001 751.798 494.511 752.288 494.511 752.892 c
b
488.468 752.849 m
488.468 753.453 488.958 753.943 489.562 753.943 c
490.166 753.943 490.656 753.453 490.656 752.849 c
490.656 752.245 490.166 751.756 489.562 751.756 c
488.958 751.756 488.468 752.245 488.468 752.849 c
b
482.337 752.677 m
482.337 753.281 482.827 753.771 483.431 753.771 c
484.035 753.771 484.524 753.281 484.524 752.677 c
484.524 752.072 484.035 751.583 483.431 751.583 c
482.827 751.583 482.337 752.072 482.337 752.677 c
b
497.554 743.372 m
497.554 743.976 498.044 744.466 498.648 744.466 c
499.252 744.466 499.742 743.976 499.742 743.372 c
499.742 742.768 499.252 742.278 498.648 742.278 c
498.044 742.278 497.554 742.768 497.554 743.372 c
b
491.642 743.675 m
491.642 744.279 492.131 744.769 492.735 744.769 c
493.339 744.769 493.829 744.279 493.829 743.675 c
493.829 743.071 493.339 742.582 492.735 742.582 c
492.131 742.582 491.642 743.071 491.642 743.675 c
b
491.642 746.806 m
491.642 747.41 492.131 747.9 492.735 747.9 c
493.339 747.9 493.829 747.41 493.829 746.806 c
493.829 746.202 493.339 745.712 492.735 745.712 c
492.131 745.712 491.642 746.202 491.642 746.806 c
b
485.343 746.67 m
485.343 747.274 485.833 747.764 486.437 747.764 c
487.041 747.764 487.53 747.274 487.53 746.67 c
487.53 746.066 487.041 745.577 486.437 745.577 c
485.833 745.577 485.343 746.066 485.343 746.67 c
b
485.337 718.589 m
485.337 719.194 485.827 719.683 486.431 719.683 c
487.035 719.683 487.525 719.194 487.525 718.589 c
487.525 717.985 487.035 717.496 486.431 717.496 c
485.827 717.496 485.337 717.985 485.337 718.589 c
b
491.511 737.241 m
491.511 737.845 492.001 738.335 492.605 738.335 c
493.209 738.335 493.698 737.845 493.698 737.241 c
493.698 736.637 493.209 736.147 492.605 736.147 c
492.001 736.147 491.511 736.637 491.511 737.241 c
b
491.511 734.198 m
491.511 734.802 492.001 735.292 492.605 735.292 c
493.209 735.292 493.698 734.802 493.698 734.198 c
493.698 733.594 493.209 733.104 492.605 733.104 c
492.001 733.104 491.511 733.594 491.511 734.198 c
b
491.772 687.372 m
491.772 687.977 492.261 688.466 492.866 688.466 c
493.47 688.466 493.959 687.977 493.959 687.372 c
493.959 686.768 493.47 686.279 492.866 686.279 c
492.261 686.279 491.772 686.768 491.772 687.372 c
b
494.642 690.718 m
494.642 691.322 495.132 691.812 495.736 691.812 c
496.34 691.812 496.829 691.322 496.829 690.718 c
496.829 690.114 496.34 689.625 495.736 689.625 c
495.132 689.625 494.642 690.114 494.642 690.718 c
b
491.772 690.588 m
491.772 691.192 492.261 691.682 492.866 691.682 c
493.47 691.682 493.959 691.192 493.959 690.588 c
493.959 689.984 493.47 689.494 492.866 689.494 c
492.261 689.494 491.772 689.984 491.772 690.588 c
b
494.642 693.849 m
494.642 694.453 495.132 694.943 495.736 694.943 c
496.34 694.943 496.829 694.453 496.829 693.849 c
496.829 693.245 496.34 692.755 495.736 692.755 c
495.132 692.755 494.642 693.245 494.642 693.849 c
b
488.599 693.677 m
488.599 694.281 489.088 694.77 489.692 694.77 c
490.296 694.77 490.786 694.281 490.786 693.677 c
490.786 693.073 490.296 692.583 489.692 692.583 c
489.088 692.583 488.599 693.073 488.599 693.677 c
b
491.642 693.849 m
491.642 694.453 492.131 694.943 492.735 694.943 c
493.339 694.943 493.829 694.453 493.829 693.849 c
493.829 693.245 493.339 692.755 492.735 692.755 c
492.131 692.755 491.642 693.245 491.642 693.849 c
b
491.642 696.892 m
491.642 697.496 492.131 697.986 492.735 697.986 c
493.339 697.986 493.829 697.496 493.829 696.892 c
493.829 696.288 493.339 695.798 492.735 695.798 c
492.131 695.798 491.642 696.288 491.642 696.892 c
b
491.511 699.892 m
491.511 700.496 492.001 700.986 492.605 700.986 c
493.209 700.986 493.698 700.496 493.698 699.892 c
493.698 699.288 493.209 698.799 492.605 698.799 c
492.001 698.799 491.511 699.288 491.511 699.892 c
b
491.511 699.85 m
491.511 700.454 492.001 700.944 492.605 700.944 c
493.209 700.944 493.698 700.454 493.698 699.85 c
493.698 699.246 493.209 698.756 492.605 698.756 c
492.001 698.756 491.511 699.246 491.511 699.85 c
b
491.511 703.153 m
491.511 703.758 492.001 704.248 492.605 704.248 c
493.209 704.248 493.698 703.758 493.698 703.153 c
493.698 702.549 493.209 702.06 492.605 702.06 c
492.001 702.06 491.511 702.549 491.511 703.153 c
b
491.511 706.154 m
491.511 706.758 492.001 707.248 492.605 707.248 c
493.209 707.248 493.698 706.758 493.698 706.154 c
493.698 705.55 493.209 705.061 492.605 705.061 c
492.001 705.061 491.511 705.55 491.511 706.154 c
b
500.946 709.197 m
500.946 709.801 501.436 710.29 502.04 710.29 c
502.644 710.29 503.133 709.801 503.133 709.197 c
503.133 708.593 502.644 708.103 502.04 708.103 c
501.436 708.103 500.946 708.593 500.946 709.197 c
b
1 w 
405.99 685.305 m
417.904 685.305 l
502.294 717.262 m
514.207 717.262 l
S
0.5 w 
497.815 709.285 m
497.815 709.889 498.305 710.379 498.909 710.379 c
499.513 710.379 500.003 709.889 500.003 709.285 c
500.003 708.681 499.513 708.191 498.909 708.191 c
498.305 708.191 497.815 708.681 497.815 709.285 c
b
494.642 709.285 m
494.642 709.889 495.132 710.379 495.736 710.379 c
496.34 710.379 496.829 709.889 496.829 709.285 c
496.829 708.681 496.34 708.191 495.736 708.191 c
495.132 708.191 494.642 708.681 494.642 709.285 c
b
491.511 709.285 m
491.511 709.889 492.001 710.379 492.605 710.379 c
493.209 710.379 493.698 709.889 493.698 709.285 c
493.698 708.681 493.209 708.191 492.605 708.191 c
492.001 708.191 491.511 708.681 491.511 709.285 c
b
488.599 709.154 m
488.599 709.759 489.088 710.248 489.692 710.248 c
490.296 710.248 490.786 709.759 490.786 709.154 c
490.786 708.55 490.296 708.061 489.692 708.061 c
489.088 708.061 488.599 708.55 488.599 709.154 c
b
494.685 712.676 m
494.685 713.28 495.175 713.77 495.779 713.77 c
496.383 713.77 496.873 713.28 496.873 712.676 c
496.873 712.072 496.383 711.582 495.779 711.582 c
495.175 711.582 494.685 712.072 494.685 712.676 c
b
491.512 712.676 m
491.512 713.28 492.002 713.77 492.606 713.77 c
493.21 713.77 493.7 713.28 493.7 712.676 c
493.7 712.072 493.21 711.582 492.606 711.582 c
492.002 711.582 491.512 712.072 491.512 712.676 c
b
488.381 712.676 m
488.381 713.28 488.871 713.77 489.475 713.77 c
490.079 713.77 490.569 713.28 490.569 712.676 c
490.569 712.072 490.079 711.582 489.475 711.582 c
488.871 711.582 488.381 712.072 488.381 712.676 c
b
485.469 712.546 m
485.469 713.15 485.959 713.639 486.563 713.639 c
487.167 713.639 487.656 713.15 487.656 712.546 c
487.656 711.941 487.167 711.452 486.563 711.452 c
485.959 711.452 485.469 711.941 485.469 712.546 c
b
494.86 718.633 m
494.86 719.237 495.349 719.726 495.954 719.726 c
496.558 719.726 497.047 719.237 497.047 718.633 c
497.047 718.029 496.558 717.539 495.954 717.539 c
495.349 717.539 494.86 718.029 494.86 718.633 c
b
491.729 718.633 m
491.729 719.237 492.218 719.726 492.822 719.726 c
493.427 719.726 493.916 719.237 493.916 718.633 c
493.916 718.029 493.427 717.539 492.822 717.539 c
492.218 717.539 491.729 718.029 491.729 718.633 c
b
491.511 721.851 m
491.511 722.455 492.001 722.945 492.605 722.945 c
493.209 722.945 493.698 722.455 493.698 721.851 c
493.698 721.247 493.209 720.757 492.605 720.757 c
492.001 720.757 491.511 721.247 491.511 721.851 c
b
488.38 721.851 m
488.38 722.455 488.87 722.945 489.474 722.945 c
490.078 722.945 490.568 722.455 490.568 721.851 c
490.568 721.247 490.078 720.757 489.474 720.757 c
488.87 720.757 488.38 721.247 488.38 721.851 c
b
491.596 730.982 m
491.596 731.586 492.086 732.076 492.69 732.076 c
493.294 732.076 493.784 731.586 493.784 730.982 c
493.784 730.378 493.294 729.888 492.69 729.888 c
492.086 729.888 491.596 730.378 491.596 730.982 c
b
488.465 730.982 m
488.465 731.586 488.955 732.076 489.559 732.076 c
490.163 732.076 490.653 731.586 490.653 730.982 c
490.653 730.378 490.163 729.888 489.559 729.888 c
488.955 729.888 488.465 730.378 488.465 730.982 c
b
488.512 715.545 m
488.512 716.149 489.002 716.639 489.606 716.639 c
490.21 716.639 490.7 716.149 490.7 715.545 c
490.7 714.941 490.21 714.451 489.606 714.451 c
489.002 714.451 488.512 714.941 488.512 715.545 c
b
494.556 715.675 m
494.556 716.279 495.045 716.769 495.649 716.769 c
496.253 716.769 496.743 716.279 496.743 715.675 c
496.743 715.071 496.253 714.582 495.649 714.582 c
495.045 714.582 494.556 715.071 494.556 715.675 c
b
491.425 715.675 m
491.425 716.279 491.914 716.769 492.519 716.769 c
493.123 716.769 493.612 716.279 493.612 715.675 c
493.612 715.071 493.123 714.582 492.519 714.582 c
491.914 714.582 491.425 715.071 491.425 715.675 c
b
494.686 727.98 m
494.686 728.585 495.176 729.074 495.78 729.074 c
496.384 729.074 496.873 728.585 496.873 727.98 c
496.873 727.376 496.384 726.887 495.78 726.887 c
495.176 726.887 494.686 727.376 494.686 727.98 c
b
491.513 727.98 m
491.513 728.585 492.003 729.074 492.607 729.074 c
493.211 729.074 493.701 728.585 493.701 727.98 c
493.701 727.376 493.211 726.887 492.607 726.887 c
492.003 726.887 491.513 727.376 491.513 727.98 c
b
488.382 727.98 m
488.382 728.585 488.872 729.074 489.476 729.074 c
490.08 729.074 490.569 728.585 490.569 727.98 c
490.569 727.376 490.08 726.887 489.476 726.887 c
488.872 726.887 488.382 727.376 488.382 727.98 c
b
485.47 727.85 m
485.47 728.454 485.96 728.944 486.564 728.944 c
487.168 728.944 487.657 728.454 487.657 727.85 c
487.657 727.246 487.168 726.756 486.564 726.756 c
485.96 726.756 485.47 727.246 485.47 727.85 c
b
488.272 724.937 m
488.272 725.541 488.762 726.031 489.366 726.031 c
489.97 726.031 490.46 725.541 490.46 724.937 c
490.46 724.333 489.97 723.843 489.366 723.843 c
488.762 723.843 488.272 724.333 488.272 724.937 c
b
494.599 725.067 m
494.599 725.671 495.088 726.161 495.692 726.161 c
496.296 726.161 496.786 725.671 496.786 725.067 c
496.786 724.463 496.296 723.973 495.692 723.973 c
495.088 723.973 494.599 724.463 494.599 725.067 c
b
491.468 725.067 m
491.468 725.671 491.957 726.161 492.561 726.161 c
493.166 726.161 493.655 725.671 493.655 725.067 c
493.655 724.463 493.166 723.973 492.561 723.973 c
491.957 723.973 491.468 724.463 491.468 725.067 c
b
488.446 740.372 m
488.446 740.976 488.935 741.466 489.54 741.466 c
490.144 741.466 490.633 740.976 490.633 740.372 c
490.633 739.768 490.144 739.278 489.54 739.278 c
488.935 739.278 488.446 739.768 488.446 740.372 c
b
494.773 740.502 m
494.773 741.106 495.262 741.596 495.866 741.596 c
496.47 741.596 496.96 741.106 496.96 740.502 c
496.96 739.898 496.47 739.408 495.866 739.408 c
495.262 739.408 494.773 739.898 494.773 740.502 c
b
491.642 740.502 m
491.642 741.106 492.131 741.596 492.735 741.596 c
493.339 741.596 493.829 741.106 493.829 740.502 c
493.829 739.898 493.339 739.408 492.735 739.408 c
492.131 739.408 491.642 739.898 491.642 740.502 c
b
494.77 678.2 m
494.77 678.804 495.26 679.294 495.864 679.294 c
496.468 679.294 496.958 678.804 496.958 678.2 c
496.958 677.596 496.468 677.107 495.864 677.107 c
495.26 677.107 494.77 677.596 494.77 678.2 c
b
491.639 678.2 m
491.639 678.804 492.129 679.294 492.733 679.294 c
493.337 679.294 493.827 678.804 493.827 678.2 c
493.827 677.596 493.337 677.107 492.733 677.107 c
492.129 677.107 491.639 677.596 491.639 678.2 c
b
491.77 674.939 m
491.77 675.543 492.26 676.033 492.864 676.033 c
493.468 676.033 493.957 675.543 493.957 674.939 c
493.957 674.335 493.468 673.845 492.864 673.845 c
492.26 673.845 491.77 674.335 491.77 674.939 c
b
488.639 674.939 m
488.639 675.543 489.129 676.033 489.733 676.033 c
490.337 676.033 490.826 675.543 490.826 674.939 c
490.826 674.335 490.337 673.845 489.733 673.845 c
489.129 673.845 488.639 674.335 488.639 674.939 c
b
BT
10 0 0 10 327.904 489.916 Tm
0 0 0 1 k
/GS3 gs
(0.01)Tj
0 10 -10 0 320.904 506.781 Tm
(PC)Tj
0 8 -8 0 320.904 518.171 Tm
(20)Tj
0 10 -10 0 320.904 525.467 Tm
[( acetaldeh)30(yde  mg\341mL)]TJ
0 8 -8 0 318.636 605.847 Tm
(-1)Tj
ET
/GS4 gs
350.904 492.632 m
350.904 623.131 l
346.904 623.131 m
350.904 623.131 l
S
BT
10 0 0 10 329.904 620.482 Tm
/GS3 gs
(100)Tj
ET
/GS4 gs
346.904 590.132 m
350.904 590.132 l
S
BT
10 0 0 10 329.904 587.482 Tm
/GS3 gs
(  10)Tj
ET
/GS4 gs
346.904 557.415 m
350.904 557.415 l
S
BT
10 0 0 10 330.471 554.766 Tm
/GS3 gs
(    1)Tj
ET
/GS4 gs
346.904 524.699 m
350.904 524.699 l
S
BT
10 0 0 10 330.471 522.049 Tm
/GS3 gs
( 0.1)Tj
ET
/GS4 gs
346.904 492.549 m
533.903 492.549 l
S
BT
10 0 0 10 312.904 620.631 Tm
/GS3 gs
(b\))Tj
ET
[4 4 ]0 d
/GS4 gs
350.904 602.033 m
534.505 602.033 l
391.403 492.632 m
391.403 489.632 l
493.903 492.632 m
493.903 489.349 l
S
BT
10 0 0 10 378.903 479.632 Tm
/GS3 gs
[(Asthma)-7267.7(Chronic)]TJ
9.706 -1 TD
(bronchitis)Tj
ET
[]0 d
/GS4 gs
405.042 609.431 m
405.042 610.036 405.531 610.525 406.135 610.525 c
406.74 610.525 407.229 610.036 407.229 609.431 c
407.229 608.827 406.74 608.338 406.135 608.338 c
405.531 608.338 405.042 608.827 405.042 609.431 c
b
398.792 609.431 m
398.792 610.036 399.281 610.525 399.885 610.525 c
400.49 610.525 400.979 610.036 400.979 609.431 c
400.979 608.827 400.49 608.338 399.885 608.338 c
399.281 608.338 398.792 608.827 398.792 609.431 c
b
392.917 609.431 m
392.917 610.036 393.406 610.525 394.01 610.525 c
394.615 610.525 395.104 610.036 395.104 609.431 c
395.104 608.827 394.615 608.338 394.01 608.338 c
393.406 608.338 392.917 608.827 392.917 609.431 c
b
386.792 609.306 m
386.792 609.911 387.281 610.4 387.885 610.4 c
388.49 610.4 388.979 609.911 388.979 609.306 c
388.979 608.702 388.49 608.213 387.885 608.213 c
387.281 608.213 386.792 608.702 386.792 609.306 c
b
380.667 609.182 m
380.667 609.786 381.156 610.275 381.761 610.275 c
382.365 610.275 382.854 609.786 382.854 609.182 c
382.854 608.577 382.365 608.088 381.761 608.088 c
381.156 608.088 380.667 608.577 380.667 609.182 c
b
1 w 
415.365 592.555 m
427.279 592.555 l
S
0.5 w 
467.291 619.431 m
467.291 620.036 467.781 620.525 468.385 620.525 c
468.989 620.525 469.479 620.036 469.479 619.431 c
469.479 618.827 468.989 618.338 468.385 618.338 c
467.781 618.338 467.291 618.827 467.291 619.431 c
b
464.166 619.431 m
464.166 620.036 464.656 620.525 465.26 620.525 c
465.864 620.525 466.354 620.036 466.354 619.431 c
466.354 618.827 465.864 618.338 465.26 618.338 c
464.656 618.338 464.166 618.827 464.166 619.431 c
b
461.041 619.431 m
461.041 620.036 461.531 620.525 462.135 620.525 c
462.739 620.525 463.229 620.036 463.229 619.431 c
463.229 618.827 462.739 618.338 462.135 618.338 c
461.531 618.338 461.041 618.827 461.041 619.431 c
b
504.541 619.431 m
504.541 620.036 505.031 620.525 505.635 620.525 c
506.239 620.525 506.729 620.036 506.729 619.431 c
506.729 618.827 506.239 618.338 505.635 618.338 c
505.031 618.338 504.541 618.827 504.541 619.431 c
b
501.416 619.431 m
501.416 620.036 501.906 620.525 502.51 620.525 c
503.114 620.525 503.604 620.036 503.604 619.431 c
503.604 618.827 503.114 618.338 502.51 618.338 c
501.906 618.338 501.416 618.827 501.416 619.431 c
b
498.291 619.431 m
498.291 620.036 498.781 620.525 499.385 620.525 c
499.989 620.525 500.479 620.036 500.479 619.431 c
500.479 618.827 499.989 618.338 499.385 618.338 c
498.781 618.338 498.291 618.827 498.291 619.431 c
b
476.666 619.431 m
476.666 620.036 477.156 620.525 477.76 620.525 c
478.364 620.525 478.854 620.036 478.854 619.431 c
478.854 618.827 478.364 618.338 477.76 618.338 c
477.156 618.338 476.666 618.827 476.666 619.431 c
b
473.541 619.431 m
473.541 620.036 474.031 620.525 474.635 620.525 c
475.239 620.525 475.729 620.036 475.729 619.431 c
475.729 618.827 475.239 618.338 474.635 618.338 c
474.031 618.338 473.541 618.827 473.541 619.431 c
b
470.416 619.431 m
470.416 620.036 470.906 620.525 471.51 620.525 c
472.114 620.525 472.604 620.036 472.604 619.431 c
472.604 618.827 472.114 618.338 471.51 618.338 c
470.906 618.338 470.416 618.827 470.416 619.431 c
b
485.916 619.431 m
485.916 620.036 486.406 620.525 487.01 620.525 c
487.614 620.525 488.104 620.036 488.104 619.431 c
488.104 618.827 487.614 618.338 487.01 618.338 c
486.406 618.338 485.916 618.827 485.916 619.431 c
b
482.791 619.431 m
482.791 620.036 483.281 620.525 483.885 620.525 c
484.489 620.525 484.979 620.036 484.979 619.431 c
484.979 618.827 484.489 618.338 483.885 618.338 c
483.281 618.338 482.791 618.827 482.791 619.431 c
b
479.666 619.431 m
479.666 620.036 480.156 620.525 480.76 620.525 c
481.364 620.525 481.854 620.036 481.854 619.431 c
481.854 618.827 481.364 618.338 480.76 618.338 c
480.156 618.338 479.666 618.827 479.666 619.431 c
b
495.291 619.431 m
495.291 620.036 495.781 620.525 496.385 620.525 c
496.989 620.525 497.479 620.036 497.479 619.431 c
497.479 618.827 496.989 618.338 496.385 618.338 c
495.781 618.338 495.291 618.827 495.291 619.431 c
b
492.166 619.431 m
492.166 620.036 492.656 620.525 493.26 620.525 c
493.864 620.525 494.354 620.036 494.354 619.431 c
494.354 618.827 493.864 618.338 493.26 618.338 c
492.656 618.338 492.166 618.827 492.166 619.431 c
b
489.041 619.431 m
489.041 620.036 489.531 620.525 490.135 620.525 c
490.739 620.525 491.229 620.036 491.229 619.431 c
491.229 618.827 490.739 618.338 490.135 618.338 c
489.531 618.338 489.041 618.827 489.041 619.431 c
b
467.291 613.181 m
467.291 613.786 467.781 614.275 468.385 614.275 c
468.989 614.275 469.479 613.786 469.479 613.181 c
469.479 612.577 468.989 612.088 468.385 612.088 c
467.781 612.088 467.291 612.577 467.291 613.181 c
b
464.166 613.181 m
464.166 613.786 464.656 614.275 465.26 614.275 c
465.864 614.275 466.354 613.786 466.354 613.181 c
466.354 612.577 465.864 612.088 465.26 612.088 c
464.656 612.088 464.166 612.577 464.166 613.181 c
b
461.041 613.181 m
461.041 613.786 461.531 614.275 462.135 614.275 c
462.739 614.275 463.229 613.786 463.229 613.181 c
463.229 612.577 462.739 612.088 462.135 612.088 c
461.531 612.088 461.041 612.577 461.041 613.181 c
b
504.541 613.181 m
504.541 613.786 505.031 614.275 505.635 614.275 c
506.239 614.275 506.729 613.786 506.729 613.181 c
506.729 612.577 506.239 612.088 505.635 612.088 c
505.031 612.088 504.541 612.577 504.541 613.181 c
b
501.416 613.181 m
501.416 613.786 501.906 614.275 502.51 614.275 c
503.114 614.275 503.604 613.786 503.604 613.181 c
503.604 612.577 503.114 612.088 502.51 612.088 c
501.906 612.088 501.416 612.577 501.416 613.181 c
b
498.291 613.181 m
498.291 613.786 498.781 614.275 499.385 614.275 c
499.989 614.275 500.479 613.786 500.479 613.181 c
500.479 612.577 499.989 612.088 499.385 612.088 c
498.781 612.088 498.291 612.577 498.291 613.181 c
b
476.666 613.181 m
476.666 613.786 477.156 614.275 477.76 614.275 c
478.364 614.275 478.854 613.786 478.854 613.181 c
478.854 612.577 478.364 612.088 477.76 612.088 c
477.156 612.088 476.666 612.577 476.666 613.181 c
b
473.541 613.181 m
473.541 613.786 474.031 614.275 474.635 614.275 c
475.239 614.275 475.729 613.786 475.729 613.181 c
475.729 612.577 475.239 612.088 474.635 612.088 c
474.031 612.088 473.541 612.577 473.541 613.181 c
b
470.416 613.181 m
470.416 613.786 470.906 614.275 471.51 614.275 c
472.114 614.275 472.604 613.786 472.604 613.181 c
472.604 612.577 472.114 612.088 471.51 612.088 c
470.906 612.088 470.416 612.577 470.416 613.181 c
b
485.916 613.181 m
485.916 613.786 486.406 614.275 487.01 614.275 c
487.614 614.275 488.104 613.786 488.104 613.181 c
488.104 612.577 487.614 612.088 487.01 612.088 c
486.406 612.088 485.916 612.577 485.916 613.181 c
b
482.791 613.181 m
482.791 613.786 483.281 614.275 483.885 614.275 c
484.489 614.275 484.979 613.786 484.979 613.181 c
484.979 612.577 484.489 612.088 483.885 612.088 c
483.281 612.088 482.791 612.577 482.791 613.181 c
b
479.666 613.181 m
479.666 613.786 480.156 614.275 480.76 614.275 c
481.364 614.275 481.854 613.786 481.854 613.181 c
481.854 612.577 481.364 612.088 480.76 612.088 c
480.156 612.088 479.666 612.577 479.666 613.181 c
b
495.291 613.181 m
495.291 613.786 495.781 614.275 496.385 614.275 c
496.989 614.275 497.479 613.786 497.479 613.181 c
497.479 612.577 496.989 612.088 496.385 612.088 c
495.781 612.088 495.291 612.577 495.291 613.181 c
b
492.166 613.181 m
492.166 613.786 492.656 614.275 493.26 614.275 c
493.864 614.275 494.354 613.786 494.354 613.181 c
494.354 612.577 493.864 612.088 493.26 612.088 c
492.656 612.088 492.166 612.577 492.166 613.181 c
b
489.041 613.181 m
489.041 613.786 489.531 614.275 490.135 614.275 c
490.739 614.275 491.229 613.786 491.229 613.181 c
491.229 612.577 490.739 612.088 490.135 612.088 c
489.531 612.088 489.041 612.577 489.041 613.181 c
b
467.291 616.181 m
467.291 616.786 467.781 617.275 468.385 617.275 c
468.989 617.275 469.479 616.786 469.479 616.181 c
469.479 615.577 468.989 615.088 468.385 615.088 c
467.781 615.088 467.291 615.577 467.291 616.181 c
b
464.166 616.181 m
464.166 616.786 464.656 617.275 465.26 617.275 c
465.864 617.275 466.354 616.786 466.354 616.181 c
466.354 615.577 465.864 615.088 465.26 615.088 c
464.656 615.088 464.166 615.577 464.166 616.181 c
b
461.041 616.181 m
461.041 616.786 461.531 617.275 462.135 617.275 c
462.739 617.275 463.229 616.786 463.229 616.181 c
463.229 615.577 462.739 615.088 462.135 615.088 c
461.531 615.088 461.041 615.577 461.041 616.181 c
b
504.541 616.181 m
504.541 616.786 505.031 617.275 505.635 617.275 c
506.239 617.275 506.729 616.786 506.729 616.181 c
506.729 615.577 506.239 615.088 505.635 615.088 c
505.031 615.088 504.541 615.577 504.541 616.181 c
b
501.416 616.181 m
501.416 616.786 501.906 617.275 502.51 617.275 c
503.114 617.275 503.604 616.786 503.604 616.181 c
503.604 615.577 503.114 615.088 502.51 615.088 c
501.906 615.088 501.416 615.577 501.416 616.181 c
b
498.291 616.181 m
498.291 616.786 498.781 617.275 499.385 617.275 c
499.989 617.275 500.479 616.786 500.479 616.181 c
500.479 615.577 499.989 615.088 499.385 615.088 c
498.781 615.088 498.291 615.577 498.291 616.181 c
b
476.666 616.181 m
476.666 616.786 477.156 617.275 477.76 617.275 c
478.364 617.275 478.854 616.786 478.854 616.181 c
478.854 615.577 478.364 615.088 477.76 615.088 c
477.156 615.088 476.666 615.577 476.666 616.181 c
b
473.541 616.181 m
473.541 616.786 474.031 617.275 474.635 617.275 c
475.239 617.275 475.729 616.786 475.729 616.181 c
475.729 615.577 475.239 615.088 474.635 615.088 c
474.031 615.088 473.541 615.577 473.541 616.181 c
b
470.416 616.181 m
470.416 616.786 470.906 617.275 471.51 617.275 c
472.114 617.275 472.604 616.786 472.604 616.181 c
472.604 615.577 472.114 615.088 471.51 615.088 c
470.906 615.088 470.416 615.577 470.416 616.181 c
b
485.916 616.181 m
485.916 616.786 486.406 617.275 487.01 617.275 c
487.614 617.275 488.104 616.786 488.104 616.181 c
488.104 615.577 487.614 615.088 487.01 615.088 c
486.406 615.088 485.916 615.577 485.916 616.181 c
b
482.791 616.181 m
482.791 616.786 483.281 617.275 483.885 617.275 c
484.489 617.275 484.979 616.786 484.979 616.181 c
484.979 615.577 484.489 615.088 483.885 615.088 c
483.281 615.088 482.791 615.577 482.791 616.181 c
b
479.666 616.181 m
479.666 616.786 480.156 617.275 480.76 617.275 c
481.364 617.275 481.854 616.786 481.854 616.181 c
481.854 615.577 481.364 615.088 480.76 615.088 c
480.156 615.088 479.666 615.577 479.666 616.181 c
b
495.291 616.181 m
495.291 616.786 495.781 617.275 496.385 617.275 c
496.989 617.275 497.479 616.786 497.479 616.181 c
497.479 615.577 496.989 615.088 496.385 615.088 c
495.781 615.088 495.291 615.577 495.291 616.181 c
b
492.166 616.181 m
492.166 616.786 492.656 617.275 493.26 617.275 c
493.864 617.275 494.354 616.786 494.354 616.181 c
494.354 615.577 493.864 615.088 493.26 615.088 c
492.656 615.088 492.166 615.577 492.166 616.181 c
b
489.041 616.181 m
489.041 616.786 489.531 617.275 490.135 617.275 c
490.739 617.275 491.229 616.786 491.229 616.181 c
491.229 615.577 490.739 615.088 490.135 615.088 c
489.531 615.088 489.041 615.577 489.041 616.181 c
b
467.291 610.181 m
467.291 610.786 467.781 611.275 468.385 611.275 c
468.989 611.275 469.479 610.786 469.479 610.181 c
469.479 609.577 468.989 609.088 468.385 609.088 c
467.781 609.088 467.291 609.577 467.291 610.181 c
b
464.166 610.181 m
464.166 610.786 464.656 611.275 465.26 611.275 c
465.864 611.275 466.354 610.786 466.354 610.181 c
466.354 609.577 465.864 609.088 465.26 609.088 c
464.656 609.088 464.166 609.577 464.166 610.181 c
b
461.041 610.181 m
461.041 610.786 461.531 611.275 462.135 611.275 c
462.739 611.275 463.229 610.786 463.229 610.181 c
463.229 609.577 462.739 609.088 462.135 609.088 c
461.531 609.088 461.041 609.577 461.041 610.181 c
b
476.666 610.181 m
476.666 610.786 477.156 611.275 477.76 611.275 c
478.364 611.275 478.854 610.786 478.854 610.181 c
478.854 609.577 478.364 609.088 477.76 609.088 c
477.156 609.088 476.666 609.577 476.666 610.181 c
b
473.541 610.181 m
473.541 610.786 474.031 611.275 474.635 611.275 c
475.239 611.275 475.729 610.786 475.729 610.181 c
475.729 609.577 475.239 609.088 474.635 609.088 c
474.031 609.088 473.541 609.577 473.541 610.181 c
b
470.416 610.181 m
470.416 610.786 470.906 611.275 471.51 611.275 c
472.114 611.275 472.604 610.786 472.604 610.181 c
472.604 609.577 472.114 609.088 471.51 609.088 c
470.906 609.088 470.416 609.577 470.416 610.181 c
b
485.916 610.181 m
485.916 610.786 486.406 611.275 487.01 611.275 c
487.614 611.275 488.104 610.786 488.104 610.181 c
488.104 609.577 487.614 609.088 487.01 609.088 c
486.406 609.088 485.916 609.577 485.916 610.181 c
b
482.791 610.181 m
482.791 610.786 483.281 611.275 483.885 611.275 c
484.489 611.275 484.979 610.786 484.979 610.181 c
484.979 609.577 484.489 609.088 483.885 609.088 c
483.281 609.088 482.791 609.577 482.791 610.181 c
b
479.666 610.181 m
479.666 610.786 480.156 611.275 480.76 611.275 c
481.364 611.275 481.854 610.786 481.854 610.181 c
481.854 609.577 481.364 609.088 480.76 609.088 c
480.156 609.088 479.666 609.577 479.666 610.181 c
b
492.166 610.181 m
492.166 610.786 492.656 611.275 493.26 611.275 c
493.864 611.275 494.354 610.786 494.354 610.181 c
494.354 609.577 493.864 609.088 493.26 609.088 c
492.656 609.088 492.166 609.577 492.166 610.181 c
b
489.041 610.181 m
489.041 610.786 489.531 611.275 490.135 611.275 c
490.739 611.275 491.229 610.786 491.229 610.181 c
491.229 609.577 490.739 609.088 490.135 609.088 c
489.531 609.088 489.041 609.577 489.041 610.181 c
b
482.791 600.806 m
482.791 601.411 483.281 601.9 483.885 601.9 c
484.489 601.9 484.979 601.411 484.979 600.806 c
484.979 600.202 484.489 599.713 483.885 599.713 c
483.281 599.713 482.791 600.202 482.791 600.806 c
b
482.791 588.432 m
482.791 589.036 483.281 589.525 483.885 589.525 c
484.489 589.525 484.979 589.036 484.979 588.432 c
484.979 587.828 484.489 587.338 483.885 587.338 c
483.281 587.338 482.791 587.828 482.791 588.432 c
b
482.666 594.807 m
482.666 595.411 483.156 595.9 483.76 595.9 c
484.364 595.9 484.854 595.411 484.854 594.807 c
484.854 594.202 484.364 593.713 483.76 593.713 c
483.156 593.713 482.666 594.202 482.666 594.807 c
b
392.917 575.557 m
392.917 576.161 393.406 576.65 394.01 576.65 c
394.615 576.65 395.104 576.161 395.104 575.557 c
395.104 574.953 394.615 574.463 394.01 574.463 c
393.406 574.463 392.917 574.953 392.917 575.557 c
b
392.917 578.682 m
392.917 579.286 393.406 579.775 394.01 579.775 c
394.615 579.775 395.104 579.286 395.104 578.682 c
395.104 578.078 394.615 577.588 394.01 577.588 c
393.406 577.588 392.917 578.078 392.917 578.682 c
b
408.042 591.182 m
408.042 591.786 408.531 592.275 409.135 592.275 c
409.739 592.275 410.229 591.786 410.229 591.182 c
410.229 590.578 409.739 590.088 409.135 590.088 c
408.531 590.088 408.042 590.578 408.042 591.182 c
b
408.167 594.306 m
408.167 594.911 408.656 595.4 409.26 595.4 c
409.864 595.4 410.354 594.911 410.354 594.306 c
410.354 593.702 409.864 593.213 409.26 593.213 c
408.656 593.213 408.167 593.702 408.167 594.306 c
b
402.292 600.431 m
402.292 601.036 402.781 601.525 403.385 601.525 c
403.99 601.525 404.479 601.036 404.479 600.431 c
404.479 599.827 403.99 599.338 403.385 599.338 c
402.781 599.338 402.292 599.827 402.292 600.431 c
b
396.042 600.306 m
396.042 600.911 396.531 601.4 397.135 601.4 c
397.74 601.4 398.229 600.911 398.229 600.306 c
398.229 599.702 397.74 599.213 397.135 599.213 c
396.531 599.213 396.042 599.702 396.042 600.306 c
b
393.042 600.431 m
393.042 601.036 393.531 601.525 394.135 601.525 c
394.74 601.525 395.229 601.036 395.229 600.431 c
395.229 599.827 394.74 599.338 394.135 599.338 c
393.531 599.338 393.042 599.827 393.042 600.431 c
b
371.417 597.182 m
371.417 597.786 371.906 598.275 372.511 598.275 c
373.115 598.275 373.604 597.786 373.604 597.182 c
373.604 596.578 373.115 596.088 372.511 596.088 c
371.906 596.088 371.417 596.578 371.417 597.182 c
b
386.667 600.306 m
386.667 600.911 387.156 601.4 387.76 601.4 c
388.365 601.4 388.854 600.911 388.854 600.306 c
388.854 599.702 388.365 599.213 387.76 599.213 c
387.156 599.213 386.667 599.702 386.667 600.306 c
b
383.667 600.306 m
383.667 600.911 384.156 601.4 384.76 601.4 c
385.365 601.4 385.854 600.911 385.854 600.306 c
385.854 599.702 385.365 599.213 384.76 599.213 c
384.156 599.213 383.667 599.702 383.667 600.306 c
b
380.792 600.306 m
380.792 600.911 381.281 601.4 381.885 601.4 c
382.49 601.4 382.979 600.911 382.979 600.306 c
382.979 599.702 382.49 599.213 381.885 599.213 c
381.281 599.213 380.792 599.702 380.792 600.306 c
b
396.042 597.431 m
396.042 598.036 396.531 598.525 397.135 598.525 c
397.74 598.525 398.229 598.036 398.229 597.431 c
398.229 596.827 397.74 596.338 397.135 596.338 c
396.531 596.338 396.042 596.827 396.042 597.431 c
b
393.042 597.431 m
393.042 598.036 393.531 598.525 394.135 598.525 c
394.74 598.525 395.229 598.036 395.229 597.431 c
395.229 596.827 394.74 596.338 394.135 596.338 c
393.531 596.338 393.042 596.827 393.042 597.431 c
b
390.167 597.431 m
390.167 598.036 390.656 598.525 391.26 598.525 c
391.865 598.525 392.354 598.036 392.354 597.431 c
392.354 596.827 391.865 596.338 391.26 596.338 c
390.656 596.338 390.167 596.827 390.167 597.431 c
b
408.042 597.557 m
408.042 598.161 408.531 598.65 409.135 598.65 c
409.739 598.65 410.229 598.161 410.229 597.557 c
410.229 596.953 409.739 596.463 409.135 596.463 c
408.531 596.463 408.042 596.953 408.042 597.557 c
b
405.042 597.557 m
405.042 598.161 405.531 598.65 406.135 598.65 c
406.74 598.65 407.229 598.161 407.229 597.557 c
407.229 596.953 406.74 596.463 406.135 596.463 c
405.531 596.463 405.042 596.953 405.042 597.557 c
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0.8251 0 TD
[(70)21.2(%)-344.6(a)0(n)15.1(d)-342.2(F)11.4(E)0(V)]TJ
7.97 0 0 7.97 281.48 590.74 Tm
(1)Tj
/F9 1 Tf
9.963 0 0 9.963 58.28 580.308 Tm
($)Tj
/F3 1 Tf
0.8251 0 TD
[(80)15.5(%)-373(p)0(r)19.6(e)0(d)15.1(i)0(c)18.4(t)0(e)18.4(d)0(\))19.6(,)-376(wh)17.3(er)19.2(ea)14.7(s)-371.8(2)0(7)-365.7(h)0(a)20.8(d)-376.3(C)11.6(O)0(P)18.1(D)-374.6(\(F)14.7(E)12.2(V)]TJ
7.97 0 0 7.97 251.66 580.308 Tm
(1)Tj
9.963 0 0 9.963 255.572 580.308 Tm
[(/F)19.6(VC)12.6(%)]TJ
/F8 1 Tf
-19.8031 -1.0527 TD
(<)Tj
/F3 1 Tf
0.5406 0 TD
[(70)15.5(%)-424.2(o)0(r)-412.8(F)11.4(EV)]TJ
7.97 0 0 7.97 116.617 569.82 Tm
(1)Tj
/F9 1 Tf
9.963 0 0 9.963 124.781 569.82 Tm
(#)Tj
/F3 1 Tf
0.8251 0 TD
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[(7)-17.2(9)4(%)-441.4(p)-17.2(re)-17.2(di)-17.2(ct)-17.2(ed)-17.2(\).)-438.7(S)-5.8(u)-17.2(bj)-17.2(ec)-17.2(ts)-440.3(w)-17.2(i)3.4(t)-17.2(h)-430.8(C)-17.2(O)-4.6(P)-5.8(D)]TJ
-7.5001 -1.0471 TD
0 Tc
[(ha)15.1(d)-365(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)12.8(a)0(n)20.8(t)0(l)16.5(y)-365(lo)18.9(we)16.9(r)-366.6(b)0(a)15.1(s)0(e)19.6(l)0(i)16.5(n)0(e)-354.7(v)0(a)15.1(l)0(u)18.9(e)0(s)-355.9(f)0(o)13.9(r)-366.6(F)11.4(E)0(V)]TJ
7.97 0 0 7.97 250.469 559.389 Tm
(1)Tj
9.963 0 0 9.963 258.066 559.389 Tm
0.3673 Tc
[(%p)367.3(r)381.3(e)367.3(-)]TJ
-20.0535 -1.0527 TD
0 Tc
[(di)18.9(ct)18.4(ed)-536.8(\(7)19.6(4.)15.9(3\213)16.7(1.)21.6(8%)13.2(\))-537.3(t)0(h)13.2(a)0(n)-531.2(t)0(h)18.9(o)0(s)14.4(e)-541.8(w)12.4(i)0(t)16.5(h)-541.4(ch)15.1(ro)19.6(ni)18.9(c)-547.5(b)0(r)19.6(o)0(n)21.2(c)0(h)15.1(i)0(t)16.5(i)0(s)]TJ
0 -1.0471 TD
[(al)18.4(on)15.5(e)-325.5(\()0(9)19.6(0)0(.)21.6(4)0(\213)16.7(2)0(.)15.9(8)0(%)18.9(,)-324.7(p)]TJ
/F8 1 Tf
8.092 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(00)15.5(1\))19.6(.)]TJ
-7.6367 -1.0527 TD
[(In)19.6(di)13.2(vi)18.9(du)21.2(al)-493.7(re)19.2(su)14.4(l)13.9(t)0(s)-494.5(f)0(o)19.6(r)-497.4(th)18.9(e)-501.9(t)0(w)14.9(o)-495.8(ch)20.8(al)12.8(le)18.4(ng)21.2(es)-492.5(in)-487.6(th)18.9(e)-501.9(t)0(w)14.9(o)]TJ
-1.0015 -1.0471 TD
[(gr)19.6(ou)15.5(ps)-298.6(ar)13.5(e)-308.5(s)0(h)20(o)0(w)17.3(n)-313.7(in)-299.8(fi)17.3(gu)21.2(re)-305.1(3.)-308.4(The)-319.8(propor)-7.8(tion)-326.5(of)-316.1(subje)-7.8(cts)]TJ
0 -1.0527 TD
[(with)-415.8(AHR)-418.9(to)-413.6(methachol)-10.3(ine)-414.8(was)-411.8(low)-8.6(er)-413.2(in)-407.9(subje)-7.8(cts)-416(with)]TJ
0 -1.0471 TD
[(chroni)-9(c)-274.3(bronchi)-9.7(tis)-275.7(alone)-280.2(\(62%\))-282.5(than)-279(in)-277.1(pati)-8.2(ents)-280.2(with)-279.2(CO-)]TJ
0 -1.0527 TD
[(PD)-226.6(\(89%,)-229.3(p)]TJ
/F8 1 Tf
4.6207 0 TD
(=)Tj
/F3 1 Tf
0.552 0 TD
[(0.03\).)-233(There)-226.6(wer)-8.2(e)-223.1(n)0(o)-223.5(differences)-228.9(in)-225.8(the)-227(prop-)]TJ
-5.1727 -1.0471 TD
[(ortion)-341(of)-333.2(subje)-7.8(cts)-336.3(with)-341.8(AHR)-339.2(to)-334(acetal)-11(dehyde)-335.4(among)-343.1(the)]TJ
0 -1.0528 TD
[(two)-344.3(groups)-348.8(\(7%)-347.7(in)-345.3(patients)-351(with)-347.5(COPD)-350.6(and)-344.1(3%)-345.3(in)-345.3(sub-)]TJ
0 -1.0471 TD
[(jects)-340.6(with)-336.1(chroni)-9(c)-336.9(bronchiti)-10.3(s)-332(alone,)-337.4(p)]TJ
/F8 1 Tf
15.0743 0 TD
(=)Tj
/F3 1 Tf
0.5577 0 TD
(0.59\).)Tj
-14.6304 -1.0527 TD
[(Th)17.1(e)-428(g)0(e)15.1(o)0(m)18.1(e)0(t)18.5(r)0(i)17.3(c)-428(me)17.7(an)-423(P)11.4(C)]TJ
7.97 0 0 7.97 167.924 444.302 Tm
-0.0163 Tc
(20)Tj
9.963 0 0 9.963 180.057 444.302 Tm
0 Tc
[(me)17.7(th)18.9(ac)14.7(ho)21.2(li)16.5(ne)-423(va)20.8(lu)18.9(e)-428(i)0(n)-419.3(t)0(h)13.2(e)]TJ
-12.2233 -1.0527 TD
[(CO)18.3(PD)-249.4(gr)14(ou)21.2(p)-256.8(\()0(1)13.9(.)0(3)21.6(5)-256.8(mg)]TJ
/F5 1 Tf
8.9797 0.2049 TD
(.)Tj
/F3 1 Tf
0.2675 -0.2049 TD
(mL)Tj
7.472 0 0 6.641 163.956 438.293 Tm
(-1)Tj
9.963 0 0 9.963 169.909 433.814 Tm
[(\))-258.4(w)0(a)16.9(s)-258(si)17.7(gn)21.2(if)17.3(ic)12.8(an)20.8(tl)16.5(y)-256.8(l)0(o)18.8(w)0(e)16.9(r)-258.4(th)18.8(an)]TJ
-11.2047 -1.0471 TD
[(in)-260(th)13.2(e)-268.6(g)0(r)19.6(o)0(u)15.5(p)-268.2(wi)14.9(th)-260(ch)15.1(ro)19.6(ni)13.2(c)-268.6(b)0(r)19.6(o)0(n)15.5(c)0(h)15.1(i)13.9(ti)16.5(s)-275.1(a)0(l)18.4(o)0(n)21.2(e)-274.3(\(3)19.6(.0)15.9(9)-268.2(m)0(g)]TJ
/F5 1 Tf
20.3209 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 277.001 427.805 Tm
-0.0185 Tc
(-1)Tj
9.963 0 0 9.963 282.954 423.383 Tm
0 Tc
(,)Tj
-22.5516 -1.0527 TD
(p)Tj
/F8 1 Tf
0.4894 0 TD
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(04)15.5(\).)]TJ
/F7 1 Tf
8.1318 -2.2535 TD
[(Discuss)-9.1(ion)]TJ
/F3 1 Tf
-8.1659 -1.6503 TD
[(In)-344.6(th)13.2(i)13.9(s)-354.8(st)12(ud)21.2(y)73.2(,)-353.2(th)13.2(e)-354(a)0(u)20.8(t)0(h)13.2(o)0(r)19.6(s)-354.8(ha)15.1(ve)-343.4(fo)19.6(un)15.5(d)-353.6(t)0(h)18.9(a)0(t)-345.7(b)0(r)14(o)0(n)21.2(c)0(h)15.1(o)0(p)21.2(r)0(o)13.9(-)]TJ
-1.0015 -1.0528 TD
[(vo)15.5(ca)20.4(ti)16.5(on)-399.9(wi)14.9(th)-402.2(ac)14.7(et)18.4(al)18.5(de)20.8(hy)15.5(de)-400.3(is)-403.4(of)-401.5(mo)18.1(re)-407.6(va)20.8(lu)18.9(e)-410.9(t)0(h)13.2(a)0(n)-400.3(b)0(r)19.6(o)0(n)15.5(-)]TJ
0 -1.0471 TD
[(ch)15.1(op)21.2(ro)13.9(vo)21.2(ca)14.7(ti)22.2(on)-456.8(wi)14.9(th)-459.2(me)17.7(th)18.9(ac)14.7(ho)21.2(li)16.5(ne)-457.2(in)-459.2(th)18.9(e)-467.8(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nt)18.9(ia)18.4(ti)16.5(on)]TJ
0 -1.0527 TD
[(of)-270.6(as)13.9(t)13.9(h)0(m)12.4(a)-280(fr)18(om)-272.1(ch)15.1(ro)19.6(ni)18.9(c)-280(b)0(r)13.9(o)0(n)21.2(c)0(h)15.1(i)0(t)16.5(i)0(s)-266.9(w)0(i)14.9(t)0(h)-271.4(o)0(r)-270.6(w)0(i)14.9(t)0(h)18.9(o)0(u)15.5(t)-282(ai)18.4(rf)18(lo)18.8(w)]TJ
25.1977 5.9011 TD
[(li)16.5(mi)15.7(ta)18.4(ti)16.5(on)15.5(.)-432.9(F)11.4(ur)19.6(th)13.2(er)19.2(mo)18.1(re)13.5(,)-427.2(t)0(h)13.2(i)13.9(s)-434.4(s)0(t)17.7(u)0(d)15.5(y)-427.6(sh)14.4(ow)17.3(s)-428.7(t)0(h)13.2(a)0(t)-419.7(a)0(s)13.9(t)0(h)18.9(m)0(a)17.7(t)0(i)16.5(c)]TJ
0 -1.0755 TD
[(pa)15.1(ti)16.5(en)20.8(ts)-352.2(de)20.8(ve)15.1(lo)18.9(p)-359.3(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(o)0(c)15.1(o)0(n)21.2(s)0(t)17.7(r)0(i)17.3(c)0(t)12.8(i)13.9(on)-348.7(in)-351(re)19.2(sp)14.3(on)21.2(se)-350.3(to)-345.3(ac)14.7(et)18.4(-)]TJ
T*
[(al)12.8(de)20.8(hy)15.5(de)-223.9(an)15.1(d)-234.1(t)0(h)13.2(a)0(t)-226.2(t)0(h)18.8(e)0(r)13.5(e)-234.5(is)-227(a)-240.2(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)12.8(a)0(n)20.8(t)-236.5(co)15.1(rr)18(el)18.5(at)12.8(i)13.9(o)0(n)-229.2(b)0(e)15.1(t)0(w)20.6(e)0(e)14.7(n)]TJ
T*
[(re)13.5(sp)20(on)15.5(si)17.7(ve)20.8(ne)15.1(ss)-299.8(to)-305.5(ac)14.7(et)18.4(al)18.4(de)15.1(hy)21.2(de)-303.5(an)15.1(d)-308.1(m)0(e)12(t)13.9(ha)15.1(ch)15.1(ol)18.9(in)18.9(e.)-303.1(Th)17.1(is)-301(is)]TJ
T*
[(in)-271.4(co)20.8(nt)13.2(ra)19.2(st)-266.9(to)-271.4(pa)20.8(ti)16.5(en)15.1(ts)-266.9(wi)14.9(th)-265.7(ch)15.1(ro)19.6(ni)18.9(c)-280(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(i)0(t)16.5(i)0(s)-266.9(w)0(h)17.3(o)-279.6(in)-265.7(ge)15.1(n-)]TJ
T*
[(er)13.5(al)-453.9(di)18.9(d)-467.4(n)0(o)15.5(t)-464.1(de)20.8(ve)15.1(lo)18.9(p)-467.4(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(o)0(c)15.1(o)0(n)21.2(s)0(t)17.7(r)0(i)17.3(c)0(t)12.8(i)0(o)18.9(n)-461.7(wi)14.9(th)-459.2(ac)20.4(et)18.4(al)12.8(de)20.8(-)]TJ
T*
[(hy)15.5(de)-240.9(de)20.8(sp)14.4(it)16.5(e)-245.9(a)0(n)-240.9(i)0(n)18.8(c)0(r)13.5(e)0(a)20.4(s)0(e)13.9(d)-245.5(re)13.5(sp)20(on)15.5(si)17.7(ve)20.8(ne)15.1(ss)-237.2(to)-242.9(me)17.7(th)13.2(ac)20.4(ho)15.5(li)22.2(ne)15.1(.)]TJ
0 -1.0698 TD
[(Th)17.1(es)13.9(e)-388.1(f)0(i)17.3(n)0(d)21.2(i)0(n)18.8(g)0(s)-378.3(s)0(u)14.4(g)0(g)21.2(e)0(s)13.9(t)-384.4(th)18.9(at)-379.9(th)18.9(e)-388.1(p)0(a)15.1(t)0(h)18.9(o)0(g)21.2(e)0(n)15.1(e)0(t)18.5(i)0(c)-379.9(m)0(e)17.7(c)0(h)15.1(a)0(n)20.8(i)0(s)17.7(m)]TJ
0 -1.0755 TD
[(le)12.8(ad)20.8(in)18.9(g)-387.7(t)0(o)-373.8(A)0(H)13.4(R)-386.7(is)-375(di)18.9(f)20.4(f)0(e)13.5(r)0(e)19.2(n)0(t)-379.5(i)0(n)-373.8(p)0(a)15.1(t)0(i)22.2(e)0(n)15.1(t)0(s)-375(w)0(i)14.9(t)0(h)-373.8(a)0(s)13.9(t)0(h)18.8(m)0(a)-375(a)0(n)15.1(d)]TJ
T*
[(wi)14.9(th)-316.9(ch)20.8(ro)13.9(ni)18.9(c)-325.5(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(i)0(t)16.5(i)0(s)17.7(.)]TJ
1.0015 -1.0527 TD
[(T)69.1(o)-330.8(th)18.8(e)-336.9(b)0(e)20.8(s)0(t)-323.8(o)0(f)-321.8(t)0(h)18.8(e)-336.9(au)20.8(th)18.8(or)14(s)]TJ
/F11 1 Tf
10.3056 0 TD
(')Tj
/F3 1 Tf
0.5463 0 TD
[(kn)15.5(ow)17.3(le)18.4(dg)15.5(e,)-320.2(no)-325.9(pr)19.6(ev)15.1(i)13.9(o)0(u)15.5(s)-332(in)18.8(-)]TJ
-11.8534 -1.0698 TD
[(fo)13.9(rm)16.5(at)18.4(io)18.8(n)-467.4(i)0(s)-460.3(a)0(v)20.8(a)0(i)18.4(l)0(a)18.5(b)0(l)13.2(e)-462.1(on)-456.8(di)13.2(f)20.4(f)0(e)19.2(r)0(e)13.5(n)0(c)20.8(e)0(s)-458.4(i)0(n)-459.2(a)0(i)18.5(r)0(w)15.7(a)0(y)-457.2(r)0(e)19.2(s)0(p)14.3(o)0(n)21.2(-)]TJ
0 -1.0755 TD
[(si)17.7(ve)15.1(ne)15.1(ss)-339.7(to)-345.3(in)13.2(ha)20.8(le)18.5(d)-353.6(a)0(c)14.7(e)0(t)18.5(a)0(l)18.5(d)0(e)15.1(h)0(y)15.5(d)0(e)-343.4(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)-353.6(as)19.6(th)18.8(ma)17.7(ti)16.5(cs)-344.6(an)15.1(d)]TJ
T*
[(pa)15.1(ti)16.5(en)20.8(ts)-238.4(wi)14.9(th)-237.2(ch)15.1(ro)19.6(ni)18.9(c)-245.9(b)0(r)14(o)0(n)21.2(c)0(h)15.1(i)0(t)16.5(i)0(s)17.7(.)-245.1(In)-236.4(th)13.2(e)-245.9(p)0(r)19.6(e)0(s)19.6(e)0(n)15.1(t)-247.8(st)17.7(ud)21.2(y)67.5(,)-245.1(a)-245.9(f)0(a)19.2(l)0(l)]TJ
T*
[(in)-214.5(FE)17.9(V)]TJ
7.97 0 0 7.97 337.549 251.716 Tm
(1)Tj
9.963 0 0 9.963 343.786 251.716 Tm
(of)Tj
/F8 1 Tf
1.0357 0 TD
(>)Tj
/F3 1 Tf
0.5406 0 TD
[(20)15.5(%)-225.1(w)12.4(as)-219.4(de)20.8(te)18.4(ct)18.5(ed)-218.2(in)-214.5(92)21.2(%)-225.1(o)0(f)-213.7(t)0(h)18.9(e)-223.1(su)14.4(bj)18.8(ec)14.7(ts)-210(wi)14.9(th)]TJ
-5.0361 -1.0755 TD
[(as)13.9(th)18.9(ma)-346.5(af)19.2(te)12.8(r)-349.5(i)0(n)13.2(h)0(a)20.8(l)0(a)18.4(t)0(i)16.5(o)0(n)-343(o)0(f)-350.3(a)0(c)20.4(e)0(t)18.4(a)0(l)18.5(d)0(e)15.1(h)0(y)15.5(d)0(e)-343.4(i)0(n)-345.3(c)0(o)20.8(n)0(c)15.1(e)0(n)20.8(t)0(r)17.3(a)0(t)12.8(i)0(o)18.8(n)0(s)]TJ
T*
[(up)-246.2(to)-248.6(40)-246.2(mg)]TJ
/F5 1 Tf
4.763 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 373.039 234.709 Tm
(-1)Tj
9.963 0 0 9.963 378.992 230.287 Tm
[(,)-256.5(w)12.4(he)15.1(re)19.2(as)-247.8(th)18.9(is)-249.8(wa)16.9(s)-252.3(d)0(e)15.1(t)0(e)18.5(c)0(t)18.5(e)0(d)-246.6(i)0(n)-248.6(o)0(n)15.5(l)0(y)-242.9(t)0(h)13.2(r)0(e)19.2(e)]TJ
-6.9937 -1.0755 TD
[(pa)15.1(ti)16.5(en)20.8(ts)-306.7(\(5)13.9(%\))-301.4(wi)14.9(th)-305.5(ch)15.1(ro)19.6(ni)18.9(c)-314.2(b)0(r)14(o)0(n)21.2(c)0(h)15.1(i)0(t)16.5(i)0(s)17.7(.)-313.4(In)-304.7(co)20.8(nt)18.8(ra)13.5(st)17.7(,)-313.4(a)-314.2(st)17.7(ri)17.3(k-)]TJ
0 -1.0698 TD
[(in)13.2(gl)18.9(y)-342.2(h)0(i)18.9(g)0(h)-331.6(p)0(r)13.9(o)0(p)21.2(o)0(r)14(t)0(i)16.5(o)0(n)-331.6(\()0(7)19.6(6)0(%)13.2(\))-343.8(of)-333.2(th)18.9(e)-342.6(s)0(u)14.3(b)0(j)18.9(e)0(c)20.4(t)0(s)-335.2(w)0(i)14.9(t)0(h)-334(c)0(h)20.8(r)0(o)13.9(n)0(i)18.8(c)]TJ
0 -1.0755 TD
[(br)13.9(on)21.2(ch)15.1(it)16.5(is)-352.2(ex)15.1(hi)18.9(bi)18.9(te)12.8(d)-359.3(A)0(H)13.4(R)-364(to)-356.7(me)17.7(th)18.9(ac)14.7(ho)15.5(l)13.9(i)0(n)13.2(e)0(,)-354.4(i)0(n)-356.7(a)0(g)20.8(r)0(e)13.5(e)0(m)17.7(e)0(n)20.8(t)]TJ
T*
[(wi)14.9(th)-311.2(pr)19.6(ev)15.1(io)18.8(us)-310(ob)21.2(se)13.9(rv)19.6(at)18.5(io)13.2(ns)-304.3(by)-308.8(ot)13.2(he)20.8(rs)-311.6(of)-310.4(A)12.4(H)0(R)-311.8(t)0(o)-311.2(p)0(h)15.5(a)0(r)19.2(m)0(a)17.7(-)]TJ
T*
[(co)15.1(lo)18.8(gi)18.9(ca)14.7(l)-441.3(a)0(g)20.8(e)0(n)15.1(t)0(s)-431.9(\()0(h)19.6(i)0(s)17.7(t)0(a)12.8(m)0(i)15.7(n)0(e)-428.7(o)0(r)-435.6(m)0(e)17.7(t)0(h)18.9(a)0(c)14.7(h)0(o)21.2(l)0(i)16.5(n)0(e)15.1(\))-440.5(in)-430.7(ch)20.8(ro)13.9(ni)18.8(c)]TJ
T*
[(br)13.9(on)21.2(ch)15.1(it)16.5(is)-306.7(wi)14.9(th)-305.5(or)-304.7(wi)14.9(th)18.9(ou)15.5(t)-316.1(a)0(i)18.4(r)0(f)18(l)0(o)18.9(w)-317.7(li)16.5(mi)15.7(ta)18.4(ti)16.5(on)-308.8([4)19.6(\2619].)-328.6(How-)]TJ
T*
[(eve)-8.8(r)31.8(,)-210.9(taken)-217.6(as)-213.7(a)-211.7(group,)-216.3(the)-209.9(deg)-8.4(ree)-209.6(of)-213.7(met)-8.2(hachol)-7.8(ine)-209.9(respon)-7.8(-)]TJ
T*
[(siven)-7.8(ess)-261.2(was)-269.6(significantl)-13.3(y)-256.8(less)-8.2(,)-262.1(\(higher)-267.4(PC)]TJ
7.97 0 0 7.97 477.808 144.624 Tm
(20)Tj
9.963 0 0 9.963 488.353 144.624 Tm
[(values)-9(\))-258.4(than)]TJ
-17.9708 -1.0698 TD
[(that)-275.7(found)-272.9(in)-271.4(the)-272.5(group)-272.9(of)-270.6(asthm)-10.9(atics.)-272.7(The)-274.3(presen)-8.2(t)-270.6(report,)]TJ
0 -1.0755 TD
[(by)-445.4(show)-8.2(ing)-442.8(that)-452.1(inhaled)-449.1(acetaldeh)-13.6(yde)-440.9(ca)-8(uses)-444(broncho)-7.3(-)]TJ
T*
[(con)-8.4(striction)-383.8(in)-373.8(subje)-7.8(cts)-376.2(with)-381.6(asthma,)-382.4(is)-375(in)-379.5(keeping)-378.4(with)]TJ
/F16 1 Tf
0 10 -10 0 68.766 190.686 Tm
0 0 0 1 k
/GS3 gs
(PC)Tj
0 8 -8 0 68.766 202.076 Tm
(20)Tj
0 10 -10 0 68.766 209.372 Tm
[( acetaldeh)30(yde  Log mg\341mL)]TJ
0 8 -8 0 65.931 305.711 Tm
(-1)Tj
ET
0 0 0 1 K
0 J 0 j 0.5 w 3.864 M []0 d
/GS4 gs
1 i 
95.266 178.186 m
95.266 320.185 l
S
BT
10 0 0 10 75.266 317.469 Tm
/GS3 gs
(1.8)Tj
ET
/GS4 gs
91.266 320.185 m
95.266 320.185 l
S
BT
10 0 0 10 75.266 299.969 Tm
/GS3 gs
(1.6)Tj
ET
/GS4 gs
91.266 302.685 m
95.266 302.685 l
S
BT
10 0 0 10 75.266 281.335 Tm
/GS3 gs
(1.4)Tj
ET
/GS4 gs
91.266 284.051 m
95.266 284.051 l
S
BT
10 0 0 10 75.266 263.552 Tm
/GS3 gs
(1.2)Tj
ET
/GS4 gs
91.266 266.268 m
95.266 266.268 l
S
BT
10 0 0 10 75.266 246.335 Tm
/GS3 gs
(1.0)Tj
ET
/GS4 gs
91.266 249.052 m
95.266 249.052 l
S
BT
10 0 0 10 75.266 229.119 Tm
/GS3 gs
(0.8)Tj
ET
/GS4 gs
91.266 231.835 m
95.266 231.835 l
S
BT
10 0 0 10 75.266 211.052 Tm
/GS3 gs
(0.6)Tj
ET
/GS4 gs
91.266 213.768 m
95.266 213.768 l
S
BT
10 0 0 10 75.266 193.268 Tm
/GS3 gs
(0.4)Tj
ET
/GS4 gs
91.266 195.985 m
95.266 195.985 l
S
BT
10 0 0 10 75.266 175.485 Tm
/GS3 gs
(0.2)Tj
ET
/GS4 gs
91.266 178.201 m
95.266 178.201 l
S
163.905 288.623 m
163.905 289.21 164.381 289.685 164.967 289.685 c
165.554 289.685 166.03 289.21 166.03 288.623 c
166.03 288.036 165.554 287.56 164.967 287.56 c
164.381 287.56 163.905 288.036 163.905 288.623 c
b
163.78 300.123 m
163.78 300.71 164.256 301.185 164.842 301.185 c
165.429 301.185 165.905 300.71 165.905 300.123 c
165.905 299.536 165.429 299.06 164.842 299.06 c
164.256 299.06 163.78 299.536 163.78 300.123 c
b
157.53 285.623 m
157.53 286.21 158.006 286.685 158.592 286.685 c
159.179 286.685 159.655 286.21 159.655 285.623 c
159.655 285.036 159.179 284.56 158.592 284.56 c
158.006 284.56 157.53 285.036 157.53 285.623 c
b
154.405 270.623 m
154.405 271.21 154.881 271.685 155.467 271.685 c
156.054 271.685 156.53 271.21 156.53 270.623 c
156.53 270.036 156.054 269.56 155.467 269.56 c
154.881 269.56 154.405 270.036 154.405 270.623 c
b
148.28 257.498 m
148.28 258.085 148.756 258.56 149.342 258.56 c
149.929 258.56 150.405 258.085 150.405 257.498 c
150.405 256.911 149.929 256.436 149.342 256.436 c
148.756 256.436 148.28 256.911 148.28 257.498 c
b
145.155 267.248 m
145.155 267.835 145.631 268.31 146.217 268.31 c
146.804 268.31 147.28 267.835 147.28 267.248 c
147.28 266.661 146.804 266.185 146.217 266.185 c
145.631 266.185 145.155 266.661 145.155 267.248 c
b
154.53 289.623 m
154.53 290.21 155.006 290.685 155.592 290.685 c
156.179 290.685 156.655 290.21 156.655 289.623 c
156.655 289.036 156.179 288.56 155.592 288.56 c
155.006 288.56 154.53 289.036 154.53 289.623 c
b
151.53 299.123 m
151.53 299.71 152.006 300.185 152.592 300.185 c
153.179 300.185 153.655 299.71 153.655 299.123 c
153.655 298.536 153.179 298.06 152.592 298.06 c
152.006 298.06 151.53 298.536 151.53 299.123 c
b
151.53 290.498 m
151.53 291.085 152.006 291.56 152.592 291.56 c
153.179 291.56 153.655 291.085 153.655 290.498 c
153.655 289.911 153.179 289.435 152.592 289.435 c
152.006 289.435 151.53 289.911 151.53 290.498 c
b
145.655 300.248 m
145.655 300.835 146.131 301.31 146.717 301.31 c
147.304 301.31 147.78 300.835 147.78 300.248 c
147.78 299.661 147.304 299.185 146.717 299.185 c
146.131 299.185 145.655 299.661 145.655 300.248 c
b
142.03 253.498 m
142.03 254.085 142.506 254.561 143.092 254.561 c
143.679 254.561 144.155 254.085 144.155 253.498 c
144.155 252.911 143.679 252.435 143.092 252.435 c
142.506 252.435 142.03 252.911 142.03 253.498 c
b
136.155 252.498 m
136.155 253.085 136.631 253.56 137.217 253.56 c
137.804 253.56 138.28 253.085 138.28 252.498 c
138.28 251.911 137.804 251.435 137.217 251.435 c
136.631 251.435 136.155 251.911 136.155 252.498 c
b
139.28 267.873 m
139.28 268.46 139.756 268.935 140.342 268.935 c
140.929 268.935 141.405 268.46 141.405 267.873 c
141.405 267.286 140.929 266.81 140.342 266.81 c
139.756 266.81 139.28 267.286 139.28 267.873 c
b
130.405 260.123 m
130.405 260.71 130.881 261.185 131.468 261.185 c
132.054 261.185 132.53 260.71 132.53 260.123 c
132.53 259.536 132.054 259.061 131.468 259.061 c
130.881 259.061 130.405 259.536 130.405 260.123 c
b
130.405 261.373 m
130.405 261.96 130.881 262.435 131.468 262.435 c
132.054 262.435 132.53 261.96 132.53 261.373 c
132.53 260.786 132.054 260.31 131.468 260.31 c
130.881 260.31 130.405 260.786 130.405 261.373 c
b
130.405 275.498 m
130.405 276.085 130.881 276.56 131.468 276.56 c
132.054 276.56 132.53 276.085 132.53 275.498 c
132.53 274.911 132.054 274.435 131.468 274.435 c
130.881 274.435 130.405 274.911 130.405 275.498 c
b
139.405 282.623 m
139.405 283.21 139.881 283.685 140.467 283.685 c
141.054 283.685 141.53 283.21 141.53 282.623 c
141.53 282.036 141.054 281.56 140.467 281.56 c
139.881 281.56 139.405 282.036 139.405 282.623 c
b
206.655 301.123 m
206.655 301.71 207.13 302.185 207.717 302.185 c
208.304 302.185 208.78 301.71 208.78 301.123 c
208.78 300.536 208.304 300.06 207.717 300.06 c
207.13 300.06 206.655 300.536 206.655 301.123 c
b
203.53 301.123 m
203.53 301.71 204.005 302.185 204.592 302.185 c
205.179 302.185 205.655 301.71 205.655 301.123 c
205.655 300.536 205.179 300.06 204.592 300.06 c
204.005 300.06 203.53 300.536 203.53 301.123 c
b
197.28 301.248 m
197.28 301.835 197.755 302.31 198.342 302.31 c
198.929 302.31 199.405 301.835 199.405 301.248 c
199.405 300.661 198.929 300.185 198.342 300.185 c
197.755 300.185 197.28 300.661 197.28 301.248 c
b
197.28 298.123 m
197.28 298.71 197.755 299.185 198.342 299.185 c
198.929 299.185 199.405 298.71 199.405 298.123 c
199.405 297.536 198.929 297.06 198.342 297.06 c
197.755 297.06 197.28 297.536 197.28 298.123 c
b
194.28 289.373 m
194.28 289.96 194.755 290.435 195.342 290.435 c
195.929 290.435 196.405 289.96 196.405 289.373 c
196.405 288.786 195.929 288.31 195.342 288.31 c
194.755 288.31 194.28 288.786 194.28 289.373 c
b
197.28 284.248 m
197.28 284.835 197.755 285.31 198.342 285.31 c
198.929 285.31 199.405 284.835 199.405 284.248 c
199.405 283.661 198.929 283.185 198.342 283.185 c
197.755 283.185 197.28 283.661 197.28 284.248 c
b
199.655 233.123 m
199.655 233.71 200.13 234.186 200.717 234.186 c
201.304 234.186 201.78 233.71 201.78 233.123 c
201.78 232.536 201.304 232.061 200.717 232.061 c
200.13 232.061 199.655 232.536 199.655 233.123 c
b
191.155 301.248 m
191.155 301.835 191.63 302.31 192.217 302.31 c
192.804 302.31 193.28 301.835 193.28 301.248 c
193.28 300.661 192.804 300.185 192.217 300.185 c
191.63 300.185 191.155 300.661 191.155 301.248 c
b
188.155 297.748 m
188.155 298.335 188.63 298.81 189.217 298.81 c
189.804 298.81 190.28 298.335 190.28 297.748 c
190.28 297.161 189.804 296.685 189.217 296.685 c
188.63 296.685 188.155 297.161 188.155 297.748 c
b
179.28 300.123 m
179.28 300.71 179.755 301.185 180.342 301.185 c
180.929 301.185 181.405 300.71 181.405 300.123 c
181.405 299.536 180.929 299.06 180.342 299.06 c
179.755 299.06 179.28 299.536 179.28 300.123 c
b
188.03 289.373 m
188.03 289.96 188.505 290.435 189.092 290.435 c
189.679 290.435 190.155 289.96 190.155 289.373 c
190.155 288.786 189.679 288.31 189.092 288.31 c
188.505 288.31 188.03 288.786 188.03 289.373 c
b
200.03 241.498 m
200.03 242.085 200.505 242.561 201.092 242.561 c
201.679 242.561 202.155 242.085 202.155 241.498 c
202.155 240.911 201.679 240.435 201.092 240.435 c
200.505 240.435 200.03 240.911 200.03 241.498 c
b
193.905 270.748 m
193.905 271.335 194.38 271.81 194.967 271.81 c
195.554 271.81 196.03 271.335 196.03 270.748 c
196.03 270.161 195.554 269.685 194.967 269.685 c
194.38 269.685 193.905 270.161 193.905 270.748 c
b
188.03 280.498 m
188.03 281.085 188.505 281.56 189.092 281.56 c
189.679 281.56 190.155 281.085 190.155 280.498 c
190.155 279.911 189.679 279.435 189.092 279.435 c
188.505 279.435 188.03 279.911 188.03 280.498 c
b
184.905 268.373 m
184.905 268.96 185.38 269.435 185.967 269.435 c
186.554 269.435 187.03 268.96 187.03 268.373 c
187.03 267.786 186.554 267.31 185.967 267.31 c
185.38 267.31 184.905 267.786 184.905 268.373 c
b
160.155 231.248 m
160.155 231.835 160.631 232.311 161.217 232.311 c
161.804 232.311 162.28 231.835 162.28 231.248 c
162.28 230.661 161.804 230.186 161.217 230.186 c
160.631 230.186 160.155 230.661 160.155 231.248 c
b
175.655 240.623 m
175.655 241.21 176.13 241.686 176.717 241.686 c
177.304 241.686 177.78 241.21 177.78 240.623 c
177.78 240.036 177.304 239.561 176.717 239.561 c
176.13 239.561 175.655 240.036 175.655 240.623 c
b
175.655 244.248 m
175.655 244.835 176.13 245.31 176.717 245.31 c
177.304 245.31 177.78 244.835 177.78 244.248 c
177.78 243.661 177.304 243.186 176.717 243.186 c
176.13 243.186 175.655 243.661 175.655 244.248 c
b
176.03 285.623 m
176.03 286.21 176.505 286.685 177.092 286.685 c
177.679 286.685 178.155 286.21 178.155 285.623 c
178.155 285.036 177.679 284.56 177.092 284.56 c
176.505 284.56 176.03 285.036 176.03 285.623 c
b
169.655 273.873 m
169.655 274.46 170.13 274.935 170.717 274.935 c
171.304 274.935 171.78 274.46 171.78 273.873 c
171.78 273.286 171.304 272.81 170.717 272.81 c
170.13 272.81 169.655 273.286 169.655 273.873 c
b
160.405 259.498 m
160.405 260.085 160.881 260.56 161.467 260.56 c
162.054 260.56 162.53 260.085 162.53 259.498 c
162.53 258.911 162.054 258.435 161.467 258.435 c
160.881 258.435 160.405 258.911 160.405 259.498 c
b
157.28 259.998 m
157.28 260.585 157.756 261.06 158.342 261.06 c
158.929 261.06 159.405 260.585 159.405 259.998 c
159.405 259.411 158.929 258.935 158.342 258.935 c
157.756 258.935 157.28 259.411 157.28 259.998 c
b
163.53 265.623 m
163.53 266.21 164.006 266.685 164.592 266.685 c
165.179 266.685 165.655 266.21 165.655 265.623 c
165.655 265.036 165.179 264.56 164.592 264.56 c
164.006 264.56 163.53 265.036 163.53 265.623 c
b
160.53 268.873 m
160.53 269.46 161.006 269.935 161.592 269.935 c
162.179 269.935 162.655 269.46 162.655 268.873 c
162.655 268.286 162.179 267.81 161.592 267.81 c
161.006 267.81 160.53 268.286 160.53 268.873 c
b
160.53 269.998 m
160.53 270.585 161.006 271.06 161.592 271.06 c
162.179 271.06 162.655 270.585 162.655 269.998 c
162.655 269.411 162.179 268.935 161.592 268.935 c
161.006 268.935 160.53 269.411 160.53 269.998 c
b
273.654 287.623 m
273.654 288.21 274.13 288.685 274.717 288.685 c
275.303 288.685 275.779 288.21 275.779 287.623 c
275.779 287.036 275.303 286.56 274.717 286.56 c
274.13 286.56 273.654 287.036 273.654 287.623 c
b
230.904 284.748 m
230.904 285.335 231.38 285.81 231.967 285.81 c
232.554 285.81 233.029 285.335 233.029 284.748 c
233.029 284.161 232.554 283.685 231.967 283.685 c
231.38 283.685 230.904 284.161 230.904 284.748 c
b
230.904 286.623 m
230.904 287.21 231.38 287.685 231.967 287.685 c
232.554 287.685 233.029 287.21 233.029 286.623 c
233.029 286.036 232.554 285.56 231.967 285.56 c
231.38 285.56 230.904 286.036 230.904 286.623 c
b
215.78 300.998 m
215.78 301.585 216.255 302.06 216.842 302.06 c
217.429 302.06 217.905 301.585 217.905 300.998 c
217.905 300.411 217.429 299.935 216.842 299.935 c
216.255 299.935 215.78 300.411 215.78 300.998 c
b
246.154 299.373 m
246.154 299.96 246.63 300.435 247.217 300.435 c
247.804 300.435 248.279 299.96 248.279 299.373 c
248.279 298.786 247.804 298.31 247.217 298.31 c
246.63 298.31 246.154 298.786 246.154 299.373 c
b
258.404 288.873 m
258.404 289.46 258.88 289.935 259.467 289.935 c
260.054 289.935 260.529 289.46 260.529 288.873 c
260.529 288.286 260.054 287.81 259.467 287.81 c
258.88 287.81 258.404 288.286 258.404 288.873 c
b
135.78 185.498 m
135.78 186.085 136.256 186.561 136.842 186.561 c
137.429 186.561 137.905 186.085 137.905 185.498 c
137.905 184.911 137.429 184.436 136.842 184.436 c
136.256 184.436 135.78 184.911 135.78 185.498 c
b
178.405 217.498 m
178.405 218.085 178.88 218.561 179.467 218.561 c
180.054 218.561 180.53 218.085 180.53 217.498 c
180.53 216.911 180.054 216.436 179.467 216.436 c
178.88 216.436 178.405 216.911 178.405 217.498 c
b
178.405 218.873 m
178.405 219.46 178.88 219.936 179.467 219.936 c
180.054 219.936 180.53 219.46 180.53 218.873 c
180.53 218.286 180.054 217.811 179.467 217.811 c
178.88 217.811 178.405 218.286 178.405 218.873 c
b
151.03 229.248 m
151.03 229.835 151.506 230.31 152.092 230.31 c
152.679 230.31 153.155 229.835 153.155 229.248 c
153.155 228.661 152.679 228.186 152.092 228.186 c
151.506 228.186 151.03 228.661 151.03 229.248 c
b
209.405 267.498 m
209.405 268.085 209.88 268.56 210.467 268.56 c
211.054 268.56 211.53 268.085 211.53 267.498 c
211.53 266.911 211.054 266.435 210.467 266.435 c
209.88 266.435 209.405 266.911 209.405 267.498 c
b
212.655 268.123 m
212.655 268.71 213.13 269.185 213.717 269.185 c
214.304 269.185 214.779 268.71 214.779 268.123 c
214.779 267.536 214.304 267.06 213.717 267.06 c
213.13 267.06 212.655 267.536 212.655 268.123 c
b
221.779 282.123 m
221.779 282.71 222.255 283.185 222.842 283.185 c
223.429 283.185 223.905 282.71 223.905 282.123 c
223.905 281.536 223.429 281.06 222.842 281.06 c
222.255 281.06 221.779 281.536 221.779 282.123 c
b
221.655 271.873 m
221.655 272.46 222.13 272.935 222.717 272.935 c
223.304 272.935 223.779 272.46 223.779 271.873 c
223.779 271.286 223.304 270.81 222.717 270.81 c
222.13 270.81 221.655 271.286 221.655 271.873 c
b
206.03 244.623 m
206.03 245.21 206.505 245.685 207.092 245.685 c
207.679 245.685 208.155 245.21 208.155 244.623 c
208.155 244.036 207.679 243.561 207.092 243.561 c
206.505 243.561 206.03 244.036 206.03 244.623 c
b
221.529 252.373 m
221.529 252.96 222.005 253.436 222.592 253.436 c
223.179 253.436 223.654 252.96 223.654 252.373 c
223.654 251.786 223.179 251.31 222.592 251.31 c
222.005 251.31 221.529 251.786 221.529 252.373 c
b
221.404 245.998 m
221.404 246.585 221.88 247.061 222.467 247.061 c
223.054 247.061 223.53 246.585 223.53 245.998 c
223.53 245.411 223.054 244.935 222.467 244.935 c
221.88 244.935 221.404 245.411 221.404 245.998 c
b
212.405 243.123 m
212.405 243.71 212.88 244.185 213.467 244.185 c
214.054 244.185 214.53 243.71 214.53 243.123 c
214.53 242.536 214.054 242.061 213.467 242.061 c
212.88 242.061 212.405 242.536 212.405 243.123 c
b
248.279 187.998 m
248.279 188.585 248.755 189.061 249.342 189.061 c
249.929 189.061 250.404 188.585 250.404 187.998 c
250.404 187.411 249.929 186.936 249.342 186.936 c
248.755 186.936 248.279 187.411 248.279 187.998 c
b
BT
10 0 0 10 275.563 165.186 Tm
/GS3 gs
(130)Tj
-11.7283 -1.25 TD
(FEV)Tj
8 0 0 8 174.23 152.686 Tm
(1)Tj
10 0 0 10 177.878 152.686 Tm
(  % predicted)Tj
ET
/GS4 gs
99.78 178.186 m
281.779 178.186 l
130.28 175.186 m
130.28 178.186 l
160.28 175.186 m
160.28 178.186 l
190.78 175.186 m
190.78 178.186 l
221.28 175.186 m
221.28 178.186 l
251.779 175.186 m
251.779 178.186 l
281.779 175.186 m
281.779 178.186 l
99.78 175.186 m
99.78 178.186 l
S
BT
10 0 0 10 246.063 165.186 Tm
/GS3 gs
(120)Tj
-3.1 0 TD
(110)Tj
-3 0 TD
(100)Tj
-2.85 0 TD
(90)Tj
-3 0 TD
(80)Tj
-3.05 0 TD
(70)Tj
/F3 1 Tf
7.97 0 0 7.97 58.28 138.104 Tm
0 g
/GS2 gs
[(Fig.)-327.1(2.)-331.2(\261)-332.2(Correlation)-470.8(between)-463.7(airway)-474.1(responsive)11(ness)-469.6(to)-474.8(acetaldehyde)]TJ
0 -1.067 TD
[(and)-241.6(baseline)-249.3(forced)-241.8(expiratory)-238.1(volume)-245.1(in)-247.2(one)-241.6(second)-242.6(\(FEV)]TJ
6.376 0 0 6.376 244.233 129.6 Tm
(1)Tj
7.97 0 0 7.97 247.464 129.6 Tm
[(\))-247.1(i)0(n)-247.2(subjects)]TJ
-23.7365 -1.0599 TD
[(with)-311.9(asthma)-309.3(\(r)]TJ
/F8 1 Tf
5.8257 0 TD
(=)Tj
/F3 1 Tf
0.5477 0 TD
[(0.13,)-311.7(p)]TJ
/F8 1 Tf
2.8097 0 TD
(=)Tj
/F3 1 Tf
0.5548 0 TD
[(0.33\).)-309.8(Individu)11.9(al)-317.3(values)-309(are)-319.1(shown.)-305.1(PC)]TJ
6.376 0 0 6.376 261.298 121.153 Tm
(20)Tj
7.97 0 0 7.97 267.704 121.153 Tm
[(:)-313.3(pro-)]TJ
-26.2759 -1.067 TD
[(vocative)-326.3(concentration)-324.5(causing)-321.2(20%)-333.2(fall)-329.9(in)-332.5(FEV)]TJ
6.376 0 0 6.376 213.619 112.649 Tm
(1)Tj
7.97 0 0 7.97 216.794 112.649 Tm
(.)Tj
/F16 1 Tf
10 0 0 10 327.904 489.916 Tm
0 0 0 1 k
/GS3 gs
(0.01)Tj
0 10 -10 0 320.904 506.781 Tm
(PC)Tj
0 8 -8 0 320.904 518.171 Tm
(20)Tj
0 10 -10 0 320.904 525.467 Tm
[( acetaldeh)30(yde  mg\341mL)]TJ
0 8 -8 0 318.636 605.847 Tm
(-1)Tj
ET
/GS4 gs
350.904 492.632 m
350.904 623.131 l
346.904 623.131 m
350.904 623.131 l
S
BT
10 0 0 10 329.904 620.482 Tm
/GS3 gs
(100)Tj
ET
/GS4 gs
346.904 590.132 m
350.904 590.132 l
S
BT
10 0 0 10 329.904 587.482 Tm
/GS3 gs
(  10)Tj
ET
/GS4 gs
346.904 557.415 m
350.904 557.415 l
S
BT
10 0 0 10 330.471 554.766 Tm
/GS3 gs
(    1)Tj
ET
/GS4 gs
346.904 524.699 m
350.904 524.699 l
S
BT
10 0 0 10 330.471 522.049 Tm
/GS3 gs
( 0.1)Tj
ET
/GS4 gs
346.904 492.549 m
533.903 492.549 l
S
BT
10 0 0 10 312.904 620.631 Tm
/GS3 gs
(b\))Tj
ET
[4 4 ]0 d
/GS4 gs
350.904 602.033 m
534.505 602.033 l
S
[]0 d
487.549 600.084 m
487.549 600.688 488.038 601.178 488.642 601.178 c
489.246 601.178 489.736 600.688 489.736 600.084 c
489.736 599.48 489.246 598.991 488.642 598.991 c
488.038 598.991 487.549 599.48 487.549 600.084 c
b
383.569 595.965 m
383.569 596.569 384.058 597.059 384.662 597.059 c
385.267 597.059 385.756 596.569 385.756 595.965 c
385.756 595.361 385.267 594.872 384.662 594.872 c
384.058 594.872 383.569 595.361 383.569 595.965 c
b
BT
10 0 0 10 327.904 638.631 Tm
/GS3 gs
(0.01)Tj
0 10 -10 0 320.904 656.348 Tm
(PC)Tj
0 8 -8 0 320.904 667.738 Tm
(20)Tj
0 10 -10 0 320.904 675.034 Tm
( methacholine  mg\341mL)Tj
0 8 -8 0 318.636 755.703 Tm
(-1)Tj
ET
/GS4 gs
350.904 641.348 m
350.904 771.847 l
346.904 771.847 m
350.904 771.847 l
S
BT
10 0 0 10 329.904 769.198 Tm
/GS3 gs
(100)Tj
ET
/GS4 gs
346.904 738.847 m
350.904 738.847 l
S
BT
10 0 0 10 329.904 736.198 Tm
/GS3 gs
(  10)Tj
ET
/GS4 gs
346.904 706.131 m
350.904 706.131 l
S
BT
10 0 0 10 330.471 703.481 Tm
/GS3 gs
(    1)Tj
ET
/GS4 gs
346.904 673.415 m
350.904 673.415 l
S
BT
10 0 0 10 330.471 670.765 Tm
/GS3 gs
( 0.1)Tj
ET
/GS4 gs
346.904 641.265 m
533.903 641.265 l
S
BT
10 0 0 10 312.904 769.347 Tm
/GS3 gs
(a\))Tj
ET
[4 4 ]0 d
/GS4 gs
350.904 745.079 m
534.505 745.079 l
382.048 641.348 m
382.048 638.348 l
487.666 641.348 m
487.666 638.064 l
S
[]0 d
380.953 674.55 m
380.953 675.154 381.442 675.644 382.046 675.644 c
382.65 675.644 383.14 675.154 383.14 674.55 c
383.14 673.946 382.65 673.456 382.046 673.456 c
381.442 673.456 380.953 673.946 380.953 674.55 c
b
378.405 736.795 m
378.405 737.4 378.895 737.889 379.499 737.889 c
380.103 737.889 380.593 737.4 380.593 736.795 c
380.593 736.191 380.103 735.702 379.499 735.702 c
378.895 735.702 378.405 736.191 378.405 736.795 c
b
378.744 743.057 m
378.744 743.662 379.234 744.151 379.838 744.151 c
380.442 744.151 380.932 743.662 380.932 743.057 c
380.932 742.453 380.442 741.964 379.838 741.964 c
379.234 741.964 378.744 742.453 378.744 743.057 c
b
378.214 714.933 m
378.214 715.537 378.704 716.027 379.308 716.027 c
379.912 716.027 380.402 715.537 380.402 714.933 c
380.402 714.329 379.912 713.839 379.308 713.839 c
378.704 713.839 378.214 714.329 378.214 714.933 c
b
381.264 702.462 m
381.264 703.066 381.753 703.556 382.357 703.556 c
382.961 703.556 383.451 703.066 383.451 702.462 c
383.451 701.858 382.961 701.368 382.357 701.368 c
381.753 701.368 381.264 701.858 381.264 702.462 c
b
378.476 705.652 m
378.476 706.256 378.965 706.746 379.569 706.746 c
380.173 706.746 380.663 706.256 380.663 705.652 c
380.663 705.048 380.173 704.559 379.569 704.559 c
378.965 704.559 378.476 705.048 378.476 705.652 c
b
384.517 705.659 m
384.517 706.263 385.007 706.753 385.611 706.753 c
386.215 706.753 386.705 706.263 386.705 705.659 c
386.705 705.055 386.215 704.565 385.611 704.565 c
385.007 704.565 384.517 705.055 384.517 705.659 c
b
384.577 714.872 m
384.577 715.476 385.067 715.966 385.671 715.966 c
386.275 715.966 386.764 715.476 386.764 714.872 c
386.764 714.268 386.275 713.779 385.671 713.779 c
385.067 713.779 384.577 714.268 384.577 714.872 c
b
381.481 736.719 m
381.481 737.323 381.971 737.813 382.575 737.813 c
383.179 737.813 383.669 737.323 383.669 736.719 c
383.669 736.115 383.179 735.626 382.575 735.626 c
381.971 735.626 381.481 736.115 381.481 736.719 c
b
381.501 739.85 m
381.501 740.454 381.99 740.944 382.594 740.944 c
383.198 740.944 383.688 740.454 383.688 739.85 c
383.688 739.246 383.198 738.756 382.594 738.756 c
381.99 738.756 381.501 739.246 381.501 739.85 c
b
381.46 730.824 m
381.46 731.428 381.949 731.918 382.553 731.918 c
383.158 731.918 383.647 731.428 383.647 730.824 c
383.647 730.22 383.158 729.73 382.553 729.73 c
381.949 729.73 381.46 730.22 381.46 730.824 c
b
381.479 733.955 m
381.479 734.559 381.969 735.049 382.573 735.049 c
383.177 735.049 383.667 734.559 383.667 733.955 c
383.667 733.351 383.177 732.861 382.573 732.861 c
381.969 732.861 381.479 733.351 381.479 733.955 c
b
377.852 680.946 m
377.852 681.55 378.342 682.04 378.946 682.04 c
379.55 682.04 380.039 681.55 380.039 680.946 c
380.039 680.342 379.55 679.852 378.946 679.852 c
378.342 679.852 377.852 680.342 377.852 680.946 c
b
1 w 
390.336 719.611 m
402.249 719.611 l
496.02 706.734 m
507.933 706.734 l
S
0.5 w 
381.917 749.147 m
381.917 749.751 382.406 750.241 383.01 750.241 c
383.615 750.241 384.104 749.751 384.104 749.147 c
384.104 748.543 383.615 748.053 383.01 748.053 c
382.406 748.053 381.917 748.543 381.917 749.147 c
b
378.792 749.147 m
378.792 749.751 379.281 750.241 379.886 750.241 c
380.49 750.241 380.979 749.751 380.979 749.147 c
380.979 748.543 380.49 748.053 379.886 748.053 c
379.281 748.053 378.792 748.543 378.792 749.147 c
b
375.667 749.147 m
375.667 749.751 376.157 750.241 376.76 750.241 c
377.365 750.241 377.854 749.751 377.854 749.147 c
377.854 748.543 377.365 748.053 376.76 748.053 c
376.157 748.053 375.667 748.543 375.667 749.147 c
b
388.042 749.147 m
388.042 749.751 388.531 750.241 389.135 750.241 c
389.74 750.241 390.229 749.751 390.229 749.147 c
390.229 748.543 389.74 748.053 389.135 748.053 c
388.531 748.053 388.042 748.543 388.042 749.147 c
b
384.917 749.147 m
384.917 749.751 385.406 750.241 386.01 750.241 c
386.615 750.241 387.104 749.751 387.104 749.147 c
387.104 748.543 386.615 748.053 386.01 748.053 c
385.406 748.053 384.917 748.543 384.917 749.147 c
b
381.388 724.449 m
381.388 725.053 381.878 725.543 382.482 725.543 c
383.086 725.543 383.576 725.053 383.576 724.449 c
383.576 723.845 383.086 723.355 382.482 723.355 c
381.878 723.355 381.388 723.845 381.388 724.449 c
b
381.408 727.58 m
381.408 728.184 381.898 728.674 382.502 728.674 c
383.106 728.674 383.595 728.184 383.595 727.58 c
383.595 726.976 383.106 726.486 382.502 726.486 c
381.898 726.486 381.408 726.976 381.408 727.58 c
b
381.317 711.8 m
381.317 712.404 381.806 712.894 382.41 712.894 c
383.015 712.894 383.504 712.404 383.504 711.8 c
383.504 711.196 383.015 710.706 382.41 710.706 c
381.806 710.706 381.317 711.196 381.317 711.8 c
b
381.336 714.931 m
381.336 715.535 381.826 716.025 382.43 716.025 c
383.034 716.025 383.524 715.535 383.524 714.931 c
383.524 714.327 383.034 713.837 382.43 713.837 c
381.826 713.837 381.336 714.327 381.336 714.931 c
b
381.317 718.074 m
381.317 718.678 381.806 719.168 382.411 719.168 c
383.015 719.168 383.504 718.678 383.504 718.074 c
383.504 717.47 383.015 716.98 382.411 716.98 c
381.806 716.98 381.317 717.47 381.317 718.074 c
b
381.336 721.205 m
381.336 721.809 381.826 722.299 382.43 722.299 c
383.034 722.299 383.524 721.809 383.524 721.205 c
383.524 720.601 383.034 720.111 382.43 720.111 c
381.826 720.111 381.336 720.601 381.336 721.205 c
b
378.311 708.765 m
378.311 709.369 378.801 709.858 379.405 709.858 c
380.009 709.858 380.498 709.369 380.498 708.765 c
380.498 708.16 380.009 707.671 379.405 707.671 c
378.801 707.671 378.311 708.16 378.311 708.765 c
b
378.331 711.895 m
378.331 712.499 378.82 712.989 379.424 712.989 c
380.028 712.989 380.518 712.499 380.518 711.895 c
380.518 711.291 380.028 710.802 379.424 710.802 c
378.82 710.802 378.331 711.291 378.331 711.895 c
b
381.406 705.729 m
381.406 706.333 381.896 706.822 382.5 706.822 c
383.104 706.822 383.594 706.333 383.594 705.729 c
383.594 705.125 383.104 704.635 382.5 704.635 c
381.896 704.635 381.406 705.125 381.406 705.729 c
b
381.426 708.86 m
381.426 709.464 381.915 709.954 382.52 709.954 c
383.124 709.954 383.613 709.464 383.613 708.86 c
383.613 708.256 383.124 707.766 382.52 707.766 c
381.915 707.766 381.426 708.256 381.426 708.86 c
b
380.817 683.985 m
380.817 684.589 381.307 685.078 381.911 685.078 c
382.515 685.078 383.004 684.589 383.004 683.985 c
383.004 683.381 382.515 682.891 381.911 682.891 c
381.307 682.891 380.817 683.381 380.817 683.985 c
b
380.836 687.116 m
380.836 687.72 381.326 688.209 381.93 688.209 c
382.534 688.209 383.024 687.72 383.024 687.116 c
383.024 686.512 382.534 686.022 381.93 686.022 c
381.326 686.022 380.836 686.512 380.836 687.116 c
b
380.918 677.783 m
380.918 678.387 381.408 678.876 382.012 678.876 c
382.616 678.876 383.106 678.387 383.106 677.783 c
383.106 677.178 382.616 676.689 382.012 676.689 c
381.408 676.689 380.918 677.178 380.918 677.783 c
b
380.938 680.913 m
380.938 681.517 381.427 682.007 382.031 682.007 c
382.635 682.007 383.125 681.517 383.125 680.913 c
383.125 680.309 382.635 679.82 382.031 679.82 c
381.427 679.82 380.938 680.309 380.938 680.913 c
b
486.798 730.288 m
486.798 730.892 487.288 731.382 487.892 731.382 c
488.496 731.382 488.986 730.892 488.986 730.288 c
488.986 729.684 488.496 729.194 487.892 729.194 c
487.288 729.194 486.798 729.684 486.798 730.288 c
b
486.818 733.419 m
486.818 734.023 487.308 734.513 487.912 734.513 c
488.516 734.513 489.005 734.023 489.005 733.419 c
489.005 732.815 488.516 732.325 487.912 732.325 c
487.308 732.325 486.818 732.815 486.818 733.419 c
b
486.9 718.044 m
486.9 718.648 487.389 719.138 487.993 719.138 c
488.597 719.138 489.087 718.648 489.087 718.044 c
489.087 717.44 488.597 716.95 487.993 716.95 c
487.389 716.95 486.9 717.44 486.9 718.044 c
b
486.919 721.175 m
486.919 721.779 487.409 722.269 488.013 722.269 c
488.617 722.269 489.107 721.779 489.107 721.175 c
489.107 720.571 488.617 720.081 488.013 720.081 c
487.409 720.081 486.919 720.571 486.919 721.175 c
b
486.828 711.729 m
486.828 712.333 487.318 712.822 487.922 712.822 c
488.526 712.822 489.016 712.333 489.016 711.729 c
489.016 711.125 488.526 710.635 487.922 710.635 c
487.318 710.635 486.828 711.125 486.828 711.729 c
b
486.848 714.86 m
486.848 715.464 487.337 715.954 487.942 715.954 c
488.546 715.954 489.035 715.464 489.035 714.86 c
489.035 714.256 488.546 713.766 487.942 713.766 c
487.337 713.766 486.848 714.256 486.848 714.86 c
b
483.477 714.907 m
483.477 715.511 483.967 716.001 484.571 716.001 c
485.175 716.001 485.664 715.511 485.664 714.907 c
485.664 714.303 485.175 713.814 484.571 713.814 c
483.967 713.814 483.477 714.303 483.477 714.907 c
b
483.497 718.038 m
483.497 718.643 483.986 719.132 484.59 719.132 c
485.195 719.132 485.684 718.643 485.684 718.038 c
485.684 717.434 485.195 716.945 484.59 716.945 c
483.986 716.945 483.497 717.434 483.497 718.038 c
b
486.858 705.425 m
486.858 706.029 487.348 706.519 487.952 706.519 c
488.556 706.519 489.045 706.029 489.045 705.425 c
489.045 704.821 488.556 704.331 487.952 704.331 c
487.348 704.331 486.858 704.821 486.858 705.425 c
b
486.878 708.556 m
486.878 709.16 487.367 709.65 487.971 709.65 c
488.575 709.65 489.065 709.16 489.065 708.556 c
489.065 707.952 488.575 707.462 487.971 707.462 c
487.367 707.462 486.878 707.952 486.878 708.556 c
b
490.126 705.497 m
490.126 706.101 490.615 706.591 491.219 706.591 c
491.824 706.591 492.313 706.101 492.313 705.497 c
492.313 704.893 491.824 704.403 491.219 704.403 c
490.615 704.403 490.126 704.893 490.126 705.497 c
b
490.146 708.628 m
490.146 709.232 490.635 709.721 491.239 709.721 c
491.843 709.721 492.333 709.232 492.333 708.628 c
492.333 708.023 491.843 707.534 491.239 707.534 c
490.635 707.534 490.146 708.023 490.146 708.628 c
b
486.947 698.776 m
486.947 699.381 487.437 699.87 488.041 699.87 c
488.645 699.87 489.135 699.381 489.135 698.776 c
489.135 698.172 488.645 697.683 488.041 697.683 c
487.437 697.683 486.947 698.172 486.947 698.776 c
b
486.967 701.908 m
486.967 702.511 487.457 703.001 488.061 703.001 c
488.665 703.001 489.155 702.511 489.155 701.908 c
489.155 701.304 488.665 700.814 488.061 700.814 c
487.457 700.814 486.967 701.304 486.967 701.908 c
b
486.876 692.747 m
486.876 693.351 487.366 693.841 487.97 693.841 c
488.574 693.841 489.063 693.351 489.063 692.747 c
489.063 692.143 488.574 691.653 487.97 691.653 c
487.366 691.653 486.876 692.143 486.876 692.747 c
b
486.895 695.878 m
486.895 696.482 487.385 696.971 487.989 696.971 c
488.593 696.971 489.083 696.482 489.083 695.878 c
489.083 695.274 488.593 694.784 487.989 694.784 c
487.385 694.784 486.895 695.274 486.895 695.878 c
b
486.632 680.33 m
486.632 680.934 487.122 681.424 487.726 681.424 c
488.33 681.424 488.819 680.934 488.819 680.33 c
488.819 679.726 488.33 679.236 487.726 679.236 c
487.122 679.236 486.632 679.726 486.632 680.33 c
b
486.651 683.461 m
486.651 684.065 487.141 684.555 487.745 684.555 c
488.349 684.555 488.839 684.065 488.839 683.461 c
488.839 682.857 488.349 682.367 487.745 682.367 c
487.141 682.367 486.651 682.857 486.651 683.461 c
b
486.805 686.544 m
486.805 687.148 487.294 687.638 487.898 687.638 c
488.502 687.638 488.992 687.148 488.992 686.544 c
488.992 685.94 488.502 685.45 487.898 685.45 c
487.294 685.45 486.805 685.94 486.805 686.544 c
b
486.824 689.675 m
486.824 690.279 487.314 690.769 487.918 690.769 c
488.522 690.769 489.012 690.279 489.012 689.675 c
489.012 689.071 488.522 688.582 487.918 688.582 c
487.314 688.582 486.824 689.071 486.824 689.675 c
b
483.965 698.765 m
483.965 699.369 484.455 699.858 485.059 699.858 c
485.663 699.858 486.153 699.369 486.153 698.765 c
486.153 698.16 485.663 697.671 485.059 697.671 c
484.455 697.671 483.965 698.16 483.965 698.765 c
b
483.965 708.491 m
483.965 709.095 484.455 709.584 485.059 709.584 c
485.663 709.584 486.153 709.095 486.153 708.491 c
486.153 707.887 485.663 707.397 485.059 707.397 c
484.455 707.397 483.965 707.887 483.965 708.491 c
b
486.636 736.83 m
486.636 737.434 487.126 737.924 487.73 737.924 c
488.334 737.924 488.823 737.434 488.823 736.83 c
488.823 736.226 488.334 735.736 487.73 735.736 c
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[(us)20(ed)-240.9(by)-246.2(i)13.9(n)0(h)15.5(a)0(l)18.5(a)0(t)18.5(i)0(o)13.2(n)-245.5(of)-242.1(ac)14.7(et)18.4(al)18.4(de)15.1(hy)21.2(de)-240.9(in)-242.9(pa)15.1(ti)16.5(en)20.8(ts)-244.1(w)12.4(i)0(t)16.5(h)-251.2(as)19.6(th)13.2(ma)]TJ
0 -1.0471 TD
[(is)-249.8(no)15.5(t)-259.2(c)0(e)14.7(r)0(t)17.3(a)0(i)18.4(n)0(,)-251.5(I)0(n)-253.5(a)-262.9(se)19.6(ri)17.3(es)-253.5(of)-247.8(st)12(ud)21.2(ie)18.4(s)-263.7(c)0(o)20.8(n)0(d)15.5(u)0(c)20.8(t)0(e)12.8(d)-256.8(in)-254.3(as)19.6(th)13.2(ma)17.7(ti)16.5(c)]TJ
0 -1.0527 TD
[(su)20(bj)13.2(ec)20.4(ts)17.7(,)-518.2(p)0(r)19.6(e)0(m)12(e)0(d)20.8(i)0(c)18.4(a)0(t)12.8(i)0(o)18.9(n)-518.6(wi)14.9(t)13.9(h)-518.6(H)]TJ
7.472 0 0 6.641 186.86 675.836 Tm
0 Tw
(1)Tj
9.963 0 0 9.963 190.488 677.48 Tm
[(-h)13.9(is)17.7(ta)18.4(mi)15.7(ne)-508.4(re)19.2(ce)14.7(pt)18.9(or)-509.6(an)15.1(-)]TJ
-13.2704 -1.0471 TD
[(ta)18.4(go)15.5(ni)18.9(st)17.7(s)-235.3([)0(1)13.9(4)0(,)-234.5(31])-248.6(a)-6.9(n)0(d)-246.2(selective)-255.8(inhi)-7.8(bitors)-251.1(of)-247.8(thromb)-11.7(oxane)]TJ
0 -1.0528 TD
[(synth)-7.4(etase)-333([16])-330.6(have)-328.2(been)-328.2(show)-8.2(n)-325.1(t)0(o)-328.3(subst)-8.6(antially)-335.1(inhibit)]TJ
0 -1.0471 TD
[(the)-494.5(acute)-491.1(broncho)-7.3(const)-7.8(rictor)-496.6(respon)-7.8(se)-486.8(to)-493.3(inhaled)-494.6(acet-)]TJ
0 -1.0527 TD
[(aldehy)-7.8(de.)-309.6(The)-6.8(refore,)-317.8(it)-313.6(is)-312.4(unlikely)-315.3(that)-315.5(acetald)-11.7(ehyde)-311.9(acts)]TJ
0 -1.0471 TD
[(direc)-8.6(tly)-439.5(on)-439.7(smoo)-7.4(th)-436.4(musc)-7.8(le)-442.5(cells)]TJ
/F4 1 Tf
13.7541 0 TD
[(in)-436.4(vivo)]TJ
/F3 1 Tf
2.8567 0 TD
[(,)-438.6(but)-442.8(indirectl)-13.1(y)]TJ
-16.6107 -1.0527 TD
[(throu)-7.8(gh)-388.5(activa)-10.6(tion)-389.1(of)-390.1(infl)-9.4(ammator)-10.7(y)-387.7(cells)-397.5(in)-390.9(the)-392(airways)]TJ
T*
[([14\26116,)-336.6(31].)-334.3(Exa)-6.8(ctly)-332.6(whi)-8.6(ch)-332(cells)-334.9(are)-334.7(stimul)-10.4(ated)-336.3(by)-331.6(acet-)]TJ
0 -1.0471 TD
[(aldehy)-7.8(de)-354.7(to)-356.7(initiate)-360.3(proces)-8.2(ses)-357.9(leading)-358(to)-356.7(smoo)-7.4(th)-351(musc)-7.8(le)]TJ
0 -1.0527 TD
[(contr)-8.2(action)-357.3(is)-352.2(as)-355.9(yet)-357.9(uncertain.)-361.9(Althoug)-8.3(h)-353.6(this)-356.1(study)-354.5(was)]TJ
0 -1.0471 TD
[(not)-243.7(designed)-243.8(to)-242.9(examine)-245.4(the)-244.1(mecha)-8.2(nism)-243.1(of)-242.1(action)-243.5(of)-242.1(acet-)]TJ
0 -1.0527 TD
[(aldehy)-7.8(de,)-503.1(the)-500.2(weak)-502.9(correl)-11(ation)-504.1(that)-503.3(was)-502.9(observ)-7.8(ed)-502.7(be-)]TJ
0 -1.0471 TD
[(tween)-636.9(methachol)-10.3(ine)-631(respon)-7.8(sivene)-9(ss)-629.9(and)-628.7(acetalde)-12.9(hyde)]TJ
0 -1.0527 TD
[(respon)-7.8(siven)-7.8(ess,)-375.3(lends)-383.4(indirect)-385.5(suppor)-7.4(t)-373(t)0(o)-379.5(the)-375(sugges)-7.4(tion)]TJ
0 -1.0471 TD
[(that)-417.9(acetal)-11(dehyde)-420.8(and)-418.1(metha)-10.1(choline)-420.6(exert)-424(their)-420.3(bronch-)]TJ
0 -1.0527 TD
[(oconst)-8.6(rictor)-331.6(eff)11.2(e)-6.9(cts)-324.9(throug)-8.6(h)-319.4(mecha)-8.2(nisms)-330.4(that)-326.9(are)-329.1(at)-323(least)]TJ
0 -1.0471 TD
[(partiall)-12.3(y)-330.8(different.)]TJ
1.0015 -1.0528 TD
[(Ov)17.3(er)-384.8(th)18.9(e)-393.8(l)0(a)18.4(s)0(t)-386.4(f)0(e)19.2(w)-397.3(ye)20.8(ar)13.5(s,)-377.9(ev)15.1(id)18.9(en)15.1(ce)-383.6(ha)20.8(s)-394.6(a)0(c)14.7(c)0(u)20.8(m)0(u)18.1(l)0(a)12.8(t)0(e)18.4(d)-393.4(to)]TJ
-1.0015 -1.0527 TD
[(su)20(pp)15.5(or)19.6(t)-264.9(t)13.9(he)-252.3(th)13.2(eo)20.8(ry)-253.5(th)18.9(at)-249(ai)12.8(rw)15.7(ay)-246.6(in)13.2(fl)17.3(am)17.7(ma)17.7(ti)16.5(on)-251.9(is)-249.8(re)19.2(sp)14.4(on)21.2(si)17.7(bl)13.2(e)]TJ
0 -1.0471 TD
[(fo)19.6(r)-264.1(s)0(t)17.7(r)0(u)19.6(c)0(t)12.8(u)0(r)19.6(a)0(l)-254.7(c)0(h)20.8(a)0(n)15.1(g)0(e)15.1(s)-258(th)18.9(at)-254.7(de)15.1(te)18.4(rm)16.5(in)18.9(e)-262.9(A)0(H)13.4(R)-261.6(in)-254.3(as)19.6(th)18.9(ma)-255.5([3)13.9(2].)]TJ
0 -1.0528 TD
[(Althoug)-8.3(h)-524.3(the)-528.6(critical)-530.6(featu)-8.6(res)-523.3(that)-531.7(determin)-10.7(e)-524.7(AHR)-527(in)]TJ
0 -1.0471 TD
[(subje)-7.8(cts)-359.1(wi)-7.8(th)-356.7(chroni)-9(c)-359.7(bronchi)-9.7(tis)-361.1(are)-363.2(not)-363.2(yet)-357.9(d)-6.5(etermine)-11.1(d,)]TJ
0 -1.0528 TD
[(eviden)-7.8(ce)-338.1(is)-340.8(now)-336.3(grow)-8.6(ing)-340.4(that)-338.3(airway)-349(inflammati)-14.5(on)-337.3(may)]TJ
0 -1.0471 TD
[(also)-257.4(play)-250.5(an)-252.3(imp)-7.8(ortant)-256(role)-257.8(in)-248.6(the)-255.5(pathog)-7.4(enesis)-254.8(of)-253.5(chroni)-9(c)]TJ
0 -1.0527 TD
[(bronchi)-9.7(tis)-332.6([19,)-334.3(20])-333.9(or)-333.2(COPD)-339.2([21\26123])-8.5(.)-330.4(However)18.5(,)-330.4(i)0(n)-334(con-)]TJ
0 -1.0471 TD
[(trast)-250.8(to)-248.6(asthma)-251.1(the)-249.8(predom)-9.7(inant)-248(type)-250.5(of)-247.8(inflamm)-12.7(atory)-247.2(cell)]TJ
0 -1.0527 TD
[(and)-480.7(the)-483.1(main)-487(anatomica)-10.7(l)-481.2(site)-481.7(of)-481.1(the)-483.1(lesion)-483.2(in)-481.9(chroni)-9(c)]TJ
0 -1.0471 TD
[(bronchi)-9.7(tis)-315.5(and)-315.7(COP)-10.1(D)-312(appear)-320.4(to)-316.9(differ)-313.7([24].)-319.6(Therefor)-10.1(e,)-314.5(if)]TJ
0 -1.0528 TD
[(relea)-9(se)-424.2(of)-424.2(broncho)-7.3(constrict)-11.9(ive)-426.2(mediator)-10.7(s)-423.1(b)0(y)-422.6(mast)-425.6(cell)-8.6(s,)]TJ
T*
[(basophi)-9.3(ls)-329.5(or)-333.2(other)-338.2(inflamm)-12.7(atory)-332.6(cell)-8.6(s)-326.3([14,)-334.3(16,)-332(3)-6.5(1)0(])-327.5(i)0(s)-335.2(the)]TJ
0 -1.0471 TD
[(main)-219.5(pathw)-10.5(ay)-212.5(by)-217.8(which)-221.1(acetal)-11(dehyde)-221.6(is)-215.7(acting,)-221.1(the)-221.3(results)]TJ
0 -1.0527 TD
[(of)-253.5(this)-248(study)-257.8(sugges)-7.4(t)-247.8(that)-252.9(the)-249.8(broncho)-13(constrictor)-259.7(respon)-7.8(se)]TJ
0 -1.0471 TD
[(to)-294.1(acetaldehyde)-300.9(invol)-8.6(ves)-294.1(one)-292.9(pathway)-297(whi)-8.6(ch)-292.2(may)-296.1(be)-292.2(ab-)]TJ
0 -1.0527 TD
[(norm)-7.8(ally)-423.6(acti)-8.6(vated)-428.1(in)-425(asthma,)-427.9(but)-425.8(not)-425.8(in)-425(chroni)-9(c)-422.3(bron-)]TJ
0 -1.0471 TD
(chitis.)Tj
1.0015 -1.0528 TD
[(Th)17.1(e)-257.2(p)0(r)13.9(i)0(m)15.7(a)0(r)19.2(y)-256.8(ai)18.5(m)-260(o)0(f)-253.5(t)0(h)18.9(e)-257.2(st)17.7(ud)15.5(y)-256.8(w)0(a)16.9(s)-258(to)-254.3(de)20.8(te)18.4(rm)16.5(in)13.2(e)-257.2(w)0(h)17.3(e)0(t)18.4(h)0(e)15.1(r)]TJ
-1.0015 -1.0471 TD
[(ac)14.7(et)18.4(al)18.5(de)15.1(hy)21.2(de)-434.4(wa)16.9(s)-445.8(a)-445(mo)18.1(re)-436(sp)20(ec)14.7(if)17.3(ic)-436.8(st)17.7(im)15.7(ul)18.9(us)-435.2(th)18.9(an)-434.4(me)17.7(th)13.2(a-)]TJ
0 -1.0528 TD
[(ch)15.1(ol)18.9(in)18.9(e)-336.9(i)0(n)-322.6(d)0(i)18.9(f)14.7(fe)19.2(re)19.2(nt)13.2(ia)18.4(ti)16.5(ng)-325.9(as)19.6(th)18.9(ma)-329.4(fr)18(om)-323.3(ch)15.1(ro)19.6(ni)13.2(c)-331.2(b)0(r)14(o)0(n)21.2(c)0(h)15.1(i)0(t)16.5(i)0(s)17.7(.)]TJ
0 -1.0471 TD
[(F)11.4(r)0(o)13.9(m)-373.8(th)18.9(e)-371.1(p)0(r)14(e)0(s)19.6(e)0(n)20.8(t)-373(re)13.5(su)20(lt)16.5(s,)-360.8(it)-364.8(is)-363.6(ev)15.1(i)13.9(d)0(e)15.1(n)0(t)-362.4(t)0(h)18.9(a)0(t)-362.8(s)0(e)13.9(n)0(s)20(i)0(t)16.5(i)0(v)18.9(i)0(t)16.5(y)-370.6(fo)13.9(r)]TJ
0 -1.0528 TD
[(ac)14.7(et)18.4(al)18.5(de)15.1(hy)21.2(de)-349.1(\(9)19.6(2%)18.9(\))-355.2(w)0(a)16.9(s)-354.8(a)-359.7(l)0(i)22.2(t)0(t)16.5(l)0(e)-345.7(l)0(e)12.8(s)0(s)-345.3(t)0(h)18.9(a)0(n)-343.4(t)0(h)13.2(a)0(t)-345.7(f)0(o)19.6(r)-355.2(me)17.7(th)18.9(a-)]TJ
T*
[(ch)15.1(ol)18.9(in)18.9(e)-336.9(\()0(1)19.6(0)0(0)15.5(%)0(\))-329.8(i)0(n)-328.3(r)0(e)19.2(v)0(e)15.1(a)0(l)18.5(i)0(n)18.9(g)-336.5(AH)13.4(R)-335.5(i)0(n)-328.3(a)0(s)19.6(t)0(h)18.9(m)0(a)17.7(.)-336.1(In)-327.5(co)15.1(nt)18.9(ra)13.5(st)17.7(,)]TJ
0 -1.0471 TD
[(br)19.6(on)15.5(ch)15.1(op)21.2(ro)19.6(vo)15.5(ca)14.7(t)13.9(i)0(o)13.2(n)-421.9(wi)14.9(th)-419.3(ac)20.4(et)18.4(al)12.8(de)20.8(hy)15.5(de)-417.3(yi)18.9(el)18.4(de)20.8(d)-427.6(c)0(o)15.1(n)0(s)20(i)0(d)18.9(e)0(r)24.9(-)]TJ
0 -1.0528 TD
[(ab)15.1(ly)-481.9(gr)13.9(ea)20.4(te)12.8(r)-491.7(s)0(p)14.4(e)0(c)20.4(i)0(f)17.3(i)0(c)18.4(i)0(t)16.5(y)-495.8(\(9)19.6(5%)13.2(\))-497.4(t)0(h)18.9(a)0(n)-485.6(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(o)0(p)15.5(r)0(o)19.6(v)0(o)15.5(c)0(a)20.4(t)0(i)16.5(o)0(n)]TJ
0 -1.0471 TD
[(wi)14.9(th)-271.4(me)17.7(th)18.9(ac)14.7(ho)21.2(li)16.5(ne)-275.1(\(2)19.6(4%)13.2(\))-281.2(i)0(n)-271.4(s)0(e)19.6(p)0(a)15.1(r)0(a)19.2(t)0(i)16.5(n)0(g)-274.7(a)0(s)19.6(t)0(h)18.9(m)0(a)-272.5(f)0(r)12.4(o)0(m)-272.1(c)0(h)20.8(r)0(o)13.9(-)]TJ
0 -1.0528 TD
[(ni)18.9(c)-501.9(b)0(r)13.9(o)0(n)21.2(c)0(h)15.1(i)0(t)16.5(i)0(s)17.7(.)-501.2(F)11.4(r)0(o)13.9(m)-499(th)18.9(es)13.9(e)-501.9(c)0(o)20.8(m)0(p)12.4(a)0(r)19.2(i)0(s)17.7(o)0(n)15.5(s)-497(it)-495.7(ap)15.1(pe)20.8(ar)13.5(s)-497(t)0(h)13.2(a)0(t)]TJ
0 -1.0471 TD
[(ac)14.7(et)18.4(al)18.5(de)15.1(hy)21.2(de)-280.8(is)-278.2(of)-282(mu)18.1(ch)-280.8(mo)18.1(re)-276.7(va)15.1(lu)18.9(e)-291.4(t)0(h)18.9(a)0(n)-280.8(m)0(e)17.7(t)0(h)18.9(a)0(c)14.7(h)0(o)21.2(l)0(i)16.5(n)0(e)-280.8(i)0(n)]TJ
0 -1.0527 TD
[(th)18.9(e)-439.3(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nt)18.9(ia)18.4(ti)16.5(on)-428.3(of)-429.9(as)19.6(th)18.9(ma)-431.9(fr)18(om)-425.8(ch)15.1(ro)19.6(ni)18.9(c)-439.3(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(i)0(t)16.5(i)0(s)-426.2(o)0(r)]TJ
0 -1.0471 TD
[(CO)18.3(PD)12.4(.)-353.2(H)0(o)17.3(w)0(e)16.9(v)0(e)15.1(r)43.2(,)-358.9(a)0(l)18.5(t)0(h)18.9(o)0(u)15.5(g)0(h)-343(t)0(h)18.9(e)-359.7(de)20.8(mo)12.4(ns)20(tr)17.3(at)18.4(io)18.9(n)-359.3(o)0(f)-344.6(b)0(r)13.9(o)0(n)21.2(c)0(h)15.1(-)]TJ
0 -1.0527 TD
[(oc)15.1(on)21.2(st)17.7(ri)17.3(ct)18.5(io)13.2(n)-336.5(i)13.9(n)-336.5(r)0(e)13.5(s)0(p)20(o)0(n)15.5(s)0(e)-327.5(t)0(o)-328.3(a)0(c)20.4(e)0(t)18.4(a)0(l)12.8(d)0(e)20.8(h)0(y)15.5(d)0(e)-326.3(m)0(a)17.7(y)-336.5(be)-326.3(a)-336.9(m)0(o)12.4(r)0(e)]TJ
0 -1.0471 TD
[(sp)20(ec)14.7(if)17.3(ic)-459.6(te)12.8(st)-460.3(th)18.9(an)-462.9(me)17.7(th)18.9(ac)14.7(ho)21.2(li)16.5(ne)-462.9(in)-464.8(t)13.9(h)0(e)-462.9(d)0(i)18.9(f)14.7(fe)19.2(re)19.2(nt)13.2(ia)18.4(ti)16.5(on)-456.8(of)]TJ
0 -1.0527 TD
[(as)19.6(th)13.2(ma)-227(fr)18(om)-232.3(ch)20.8(ro)13.9(ni)18.9(c)-234.5(b)0(r)13.9(o)0(n)21.2(c)0(h)15.1(i)0(t)16.5(i)0(s)17.7(,)-233.7(th)18.9(er)13.5(e)-234.5(i)0(s)-227(s)0(t)17.7(i)0(l)16.5(l)-236.5(th)18.9(e)-240.2(p)0(o)21.2(s)0(s)13.2(i)0(b)18.8(i)0(l)16.5(i)0(t)16.5(y)]TJ
T*
[(th)18.9(at)-317.3(as)19.6(th)13.2(ma)-312.4(co)15.1(ul)18.9(d)-325.1(b)0(e)-314.9(m)0(i)15.7(s)0(s)18.9(e)0(d)-314.9(i)0(n)-316.9(a)-325.5(fe)19.2(w)-323.4(i)0(n)13.2(d)0(i)18.9(v)0(i)18.9(d)0(u)21.2(a)0(l)12.8(s)0(.)]TJ
1.0015 -1.0471 TD
[(Al)14.9(l)-401.5(o)0(f)-390.1(t)0(h)18.9(e)-399.5(su)20(bj)13.2(ec)20.4(ts)-392.1(wi)14.9(th)]TJ
/F8 1 Tf
10.1007 0 TD
(>)Tj
/F3 1 Tf
0.5406 0 TD
[(20)15.5(%)-401.5(f)0(a)19.2(l)0(l)-393.2(i)13.9(n)-404.8(F)11.4(EV)]TJ
7.97 0 0 7.97 242.872 133.455 Tm
(1)Tj
9.963 0 0 9.963 246.784 133.455 Tm
0.3987 Tc
[(,a)398.7(f)417.9(t)398.7(e)411.5(r)-2(i)412.6(n)398.7(-)]TJ
-18.9211 -1.0528 TD
0 Tc
[(ha)15.1(la)18.4(ti)16.5(on)-399.9(of)-407.2(ac)20.4(et)12.8(al)18.4(de)20.8(hy)15.5(de)-406(sh)20(ow)17.3(ed)-406(AH)19.1(R)-415.2(t)0(o)-407.9(m)0(e)17.7(t)0(h)18.9(a)0(c)14.7(h)0(o)21.2(l)0(i)16.5(n)0(e)15.1(,)]TJ
0 -1.0471 TD
[(bu)15.5(t)-458.4(4)0(7)-456.8(s)0(u)20(b)0(j)13.2(e)0(c)20.4(t)0(s)-454.7(w)0(i)14.9(t)0(h)-453.5(a)-462.1(po)15.5(si)17.7(ti)16.5(ve)-451.5(me)17.7(th)13.2(ac)20.4(ho)15.5(li)16.5(ne)-451.5(ch)15.1(al)18.4(le)18.4(ng)15.5(e)]TJ
25.1977 66.1583 TD
[(fa)13.5(il)16.5(ed)-536.8(t)13.9(o)-547.1(re)13.5(sp)20(on)21.2(d)-547.1(t)0(o)-538.8(a)0(c)20.4(e)0(t)18.5(a)0(l)12.8(d)0(e)20.8(h)0(y)15.5(d)0(e)20.8(.)-546.7(Th)17.1(er)19.2(ef)13.5(or)19.6(e,)-536.5(in)-533.1(th)13.2(os)20(e)]TJ
0 -1.0471 TD
[(pa)15.1(ti)16.5(en)20.8(ts)-397.8(wi)14.9(th)-396.6(A)12.4(H)0(R)-397.1(t)0(o)-396.6(a)0(c)14.7(e)0(t)18.4(a)0(l)18.5(d)0(e)15.1(h)0(y)21.2(d)0(e)-394.6(t)0(h)13.2(e)-399.5(au)15.1(th)18.8(or)13.9(s)-400.3(h)0(a)15.1(v)0(e)-394.6(a)0(l)18.4(-)]TJ
0 -1.0528 TD
[(wa)16.9(ys)-361.2(ob)21.2(se)13.9(rv)19.6(ed)-354.8(hy)15.5(pe)15.1(rr)18(es)19.6(po)15.5(ns)20(iv)18.9(en)15.1(es)19.6(s)-366.2(t)0(o)-356.7(m)0(e)12(t)13.9(ha)15.1(ch)15.1(ol)18.9(in)18.9(e.)-354.4(By)]TJ
0 -1.0471 TD
[(co)15.1(nt)18.9(ra)13.5(st)17.7(,)-336.1(A)0(H)19.1(R)-341.2(to)-328.3(me)17.7(th)13.2(ac)20.4(ho)15.5(li)22.2(ne)-332(is)-329.5(no)21.2(t)-338.9(n)0(e)15.1(c)0(e)20.4(s)0(s)13.2(a)0(r)19.2(i)0(l)16.5(y)-336.5(ac)14.7(co)20.8(m-)]TJ
0 -1.0528 TD
[(pa)15.1(ni)18.9(ed)-371.8(by)-377.1(hy)21.2(pe)15.1(rr)18(es)19.6(po)15.5(ns)20(iv)18.9(en)15.1(es)19.6(s)-383.2(t)0(o)-373.8(a)0(c)20.4(e)0(t)12.8(a)0(l)18.5(d)0(e)20.8(h)0(y)15.5(d)0(e)15.1(.)-376(In)-373(ad)15.1(di)18.8(-)]TJ
0 -1.0471 TD
[(ti)16.5(on)15.5(,)-273.5(t)13.9(he)-263.7(la)12.8(ck)-263.7(of)-259.2(re)13.5(sp)20(on)15.5(se)-264.9(t)13.9(o)-273.9(ac)14.7(et)18.5(al)18.4(de)15.1(hy)21.2(de)-263.7(in)-265.7(sm)16.9(ok)21.2(er)13.5(s)-269.4(w)0(i)14.9(t)0(h)]TJ
0 -1.0528 TD
[(ch)15.1(ro)19.6(ni)13.2(c)-484.9(b)0(r)14(o)0(n)21.2(c)0(h)15.1(i)0(t)16.5(i)0(s)-477.4(i)0(s)-483.1(i)0(n)-476.2(m)0(a)12(r)0(k)19.6(e)0(d)-479.9(c)0(o)15.1(n)0(t)18.9(r)0(a)19.2(s)0(t)-483.1(t)0(o)-476.2(f)0(i)17.3(n)0(d)15.5(i)0(n)18.9(g)0(s)-480.7(i)0(n)]TJ
0 -1.0471 TD
[(as)13.9(th)18.9(ma)17.7(ti)16.5(c)-308.5(s)0(u)20(b)0(j)13.2(e)0(c)20.4(t)0(s)17.7(.)-307.7(In)-299(th)18.9(is)-301(st)17.7(ud)15.5(y)73.2(,)-307.7(57)21.2(/6)13.2(2)-308.1(a)0(s)19.6(t)0(h)18.9(m)0(a)17.7(t)0(i)16.5(c)-308.5(su)14.4(bj)18.9(ec)20.4(ts)]TJ
0 -1.0527 TD
[(wi)14.9(th)-208.8(a)-211.7(P)11.4(C)]TJ
7.97 0 0 7.97 347.187 687.968 Tm
(20)Tj
9.963 0 0 9.963 357.222 687.968 Tm
[(me)17.7(th)18.9(ac)14.7(ho)21.2(li)16.5(ne)-206.8(be)20.8(tw)14.9(ee)14.7(n)-211.3(0)0(.)15.9(0)0(4)21.2(\261)0(4)15.5(.)0(3)21.6(3)-217(mg)]TJ
/F5 1 Tf
14.3003 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 515.905 692.39 Tm
(-1)Tj
9.963 0 0 9.963 524.126 687.968 Tm
[(ex)20.8(-)]TJ
-21.5615 -1.0527 TD
[(pe)15.1(ri)17.3(en)15.1(ce)20.4(d)-456(a)-456.4(20)21.2(%)-458.4(f)0(a)19.2(l)0(l)-450.2(i)0(n)-447.8(F)11.4(EV)]TJ
7.97 0 0 7.97 430.639 677.48 Tm
(1)Tj
9.963 0 0 9.963 439.143 677.48 Tm
[(in)-447.8(re)19.2(sp)20(on)15.5(se)-447(to)-447.8(ac)20.4(et)18.4(al)12.8(de)20.8(-)]TJ
-13.0314 -1.0471 TD
[(hy)15.5(de)15.1(.)-313.4(O)0(n)-312.7(t)0(h)18.9(e)-319.8(co)15.1(nt)18.9(ra)13.5(ry)82.2(,)-319.1(o)0(n)15.5(l)13.9(y)-319.4(t)0(h)13.2(r)0(e)19.2(e)-319.8(of)-310.4(th)18.9(e)-319.8(3)0(9)-314.5(s)0(m)16.9(o)0(k)21.2(e)0(r)13.5(s)-314.9(wi)14.9(th)]TJ
0 -1.0528 TD
[(ch)15.1(ro)19.6(ni)13.2(c)-251.6(b)0(r)13.9(o)0(n)21.2(c)0(h)15.1(i)0(t)16.5(i)0(s)-244.1(w)0(h)11.6(o)-251.2(ha)15.1(d)-256.8(a)-257.3(P)11.4(C)]TJ
7.97 0 0 7.97 437.159 656.56 Tm
(20)Tj
9.963 0 0 9.963 447.59 656.56 Tm
[(me)17.7(th)18.9(ac)14.7(ho)21.2(li)16.5(ne)-246.6(in)-248.6(a)-257.2(s)0(i)17.7(m)0(-)]TJ
-13.8792 -1.0471 TD
[(il)16.5(ar)-407.6(ra)13.5(ng)21.2(e)-416.6(\()0(0)14(.)0(1)21.6(0)0(\261)15.5(4)0(.)15.9(1)0(4)-405.6(m)0(g)]TJ
/F5 1 Tf
10.1804 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 426.954 650.551 Tm
(-1)Tj
9.963 0 0 9.963 432.907 646.129 Tm
[(\))-417.8(s)0(h)14.4(o)0(w)17.3(e)0(d)-406(A)0(H)13.4(R)-415.2(to)-407.9(ac)14.7(et)18.5(al)18.4(-)]TJ
-12.4054 -1.0527 TD
[(de)15.1(hy)15.5(de)-343.4(\(f)18(ig)18.8(.)-353.2(1\).)-356.3(These)-368.4(results)-373(sugges)-7.4(t)-361.6(that)-366.7(methac)-11.3(holine)]TJ
0 -1.0471 TD
[(hyp)-8(erresponsi)-10.7(veness)-235.4(is)-227(a)-228.8(necess)-8.2(ary)58.3(,)-228(but)-232.3(not)-226.6(sufficient)-230.5(pre-)]TJ
0 -1.0527 TD
[(con)-8.4(dition)-239.3(for)-233.1(the)-238.4(expres)-8.2(sion)-234.2(of)-236.4(AHR)-242.5(to)-231.5(acetal)-11(dehyde,)-239.1(and)]TJ
0 -1.0471 TD
[(that)-292.7(methachol)-10.3(ine)-283.9(an)-7.6(d)-279.6(acetal)-11(dehyde)-289.9(hyperr)-8.2(espons)-7.4(iveness)]TJ
0 -1.0528 TD
[(are)-289.2(not)-289.2(reflecti)-12(ng)-286.1(the)-283.9(same)-292.7(pathop)-7.4(hysio)-7.4(logical)-292.1(proces)-8.2(s)-280.8(i)0(n)]TJ
0 -1.0471 TD
[(the)-340.8(airways.)]TJ
1.0015 -1.0527 TD
[(Th)17.1(e)-348.3(a)0(u)15.1(t)0(h)18.9(o)0(r)13.9(s)-343.4(ac)14.7(kn)15.5(ow)17.3(le)18.4(dg)21.2(e)-354(t)13.9(ha)15.1(t)-350.3(a)-348.3(po)21.2(te)12.8(nt)18.9(ia)18.4(l)-350.3(w)12.4(ea)14.7(kn)15.5(es)19.6(s)-349.1(o)0(f)]TJ
-1.0015 -1.0471 TD
[(th)13.2(is)-244.1(st)17.7(ud)21.2(y)-256.8(i)0(s)-244.1(t)0(h)18.9(a)0(t)-249(i)0(n)18.8(h)0(a)20.8(l)0(a)12.8(t)0(i)16.5(o)0(n)-240.5(c)0(h)15.1(a)0(l)18.5(l)0(e)18.4(n)0(g)15.5(e)0(s)-242.1(w)0(e)16.9(r)0(e)-248.2(n)0(o)15.5(t)-253.5(pe)20.8(rf)18(or)13.9(me)17.7(d)]TJ
0 -1.0528 TD
[(ra)13.5(nd)21.2(om)12.4(ly)81.4(.)-358.9(I)0(t)-358.3(h)0(a)20.8(s)-366.2(be)20.8(en)-354.8(re)13.5(po)21.2(rt)17.3(ed)-354.8(th)18.9(at)-357.1(in)18.9(ha)15.1(le)18.5(d)-365(a)0(c)20.4(e)0(t)18.4(a)0(l)12.8(d)0(e)20.8(h)0(y)15.5(d)0(e)]TJ
0 -1.0471 TD
[(in)13.2(cr)19.2(ea)14.7(se)19.6(s)-360.5(a)0(i)18.4(r)0(w)15.7(a)0(y)-349.1(r)0(e)19.2(s)0(p)14.4(o)0(n)21.2(s)0(i)17.7(v)0(e)15.1(n)0(e)20.8(s)0(s)-351(t)0(o)-351(m)0(e)17.7(t)0(h)13.2(a)0(c)20.4(h)0(o)15.5(l)0(i)16.5(n)0(e)-349.1(i)0(n)-351(a)0(s)19.6(t)0(h)18.8(-)]TJ
0 -1.0527 TD
[(ma)12(ti)16.5(c)-297.1(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)-289.6([)0(3)13.9(3],)-299.4(and)-310(for)-312.8(that)-309.8(reason)-315.5(the)-312.4(metha)-10.1(choline)]TJ
0 -1.0471 TD
[(cha)-8.8(llenge)-340.2(test)-333.8(was)-337.9(perfor)-9.8(med)-335.9(first.)]TJ
1.0015 -1.0528 TD
[(W)37.9(i)0(t)16.5(h)0(i)18.9(n)-421.9(th)18.8(e)-422.3(g)0(r)13.9(o)0(u)21.2(p)-421.9(of)-412.8(su)14.4(bj)18.9(ec)20.4(ts)-414.8(wi)14.9(th)-413.6(ch)20.8(ro)13.9(ni)18.9(c)-422.3(b)0(r)19.6(o)0(n)15.5(c)0(h)20.8(i)0(t)16.5(i)0(s)17.7(,)]TJ
-1.0015 -1.0471 TD
[(th)13.2(er)19.2(e)-388.1(w)0(a)16.9(s)-388.9(a)-388.1(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(t)-390.1(co)20.8(rr)18(el)12.8(at)18.4(io)18.9(n)-387.7(b)0(e)15.1(t)0(w)20.6(e)0(e)14.7(n)-387.7(PC)]TJ
7.97 0 0 7.97 497.877 499.691 Tm
(20)Tj
9.963 0 0 9.963 509.612 499.691 Tm
[(me)12(th)18.8(a-)]TJ
-20.1047 -1.0527 TD
[(ch)15.1(ol)18.9(in)18.8(e)-319.8(a)0(n)20.8(d)-319.4(ba)20.8(se)13.9(li)22.2(ne)-309.2(FE)17.9(V)]TJ
7.97 0 0 7.97 411.477 489.203 Tm
(1)Tj
9.963 0 0 9.963 415.389 489.203 Tm
[(.)-313.4(T)0(h)17.1(i)0(s)-306.7(i)0(s)-306.7(i)0(n)-311.2(k)0(e)20.8(e)0(p)15.1(i)0(n)18.8(g)-313.7(wi)14.9(th)-305.5(pr)13.9(ev)20.8(-)]TJ
-10.647 -1.0471 TD
[(io)13.2(us)-219(re)19.2(po)15.5(rt)17.3(s)-229.6([)0(4)19.6(,)-228(5,)-217.4(7,)-223.1(8,)-217.4(34)21.2(].)-224.7(B)11.6(y)-228.4(co)15.1(nt)18.9(ra)19.2(st)17.7(,)-228(n)0(o)-223.5(c)0(o)20.8(r)0(r)18(e)0(l)12.8(a)0(t)18.4(i)0(o)18.9(n)-228.4(wa)16.9(s)]TJ
0 -1.0528 TD
[(fo)13.9(un)21.2(d)-336.5(b)0(e)15.1(t)0(w)14.9(e)0(e)20.4(n)-336.5(me)17.7(th)13.2(ac)20.4(ho)15.5(li)16.5(ne)-326.3(or)-327.5(ac)20.4(et)12.8(al)18.5(de)20.8(hy)15.5(de)-326.3(re)13.5(sp)20(on)15.5(si)17.7(ve)20.8(-)]TJ
0 -1.0471 TD
[(ne)15.1(ss)-282.7(an)20.8(d)-296.7(b)0(a)20.8(s)0(e)19.6(l)0(i)16.5(n)0(e)-286.5(F)11.4(EV)]TJ
7.97 0 0 7.97 399.005 457.852 Tm
(1)Tj
9.963 0 0 9.963 405.864 457.852 Tm
[(in)-282.7(as)19.6(th)13.2(m)13.2(a)0(t)12.8(i)0(c)18.4(s)0(.)-281.2(H)0(o)17.3(w)0(e)16.9(v)0(e)15.1(r)43.2(,)-290.6(t)0(h)13.2(e)-291.4(as)19.6(th)18.8(-)]TJ
-9.691 -1.0528 TD
[(ma)12(ti)16.5(c)-217.4(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)-210(d)0(i)18.9(s)0(p)20(l)0(a)12.8(y)0(e)20.8(d)-217(a)-223.1(r)0(e)19.2(l)0(a)18.4(t)0(i)16.5(v)0(e)15.1(l)0(y)-208.8(n)0(a)20.8(r)0(r)12.4(o)0(w)-210.3(r)0(a)19.2(n)0(g)15.5(e)-217.4(of)-208(FE)17.9(V)]TJ
7.97 0 0 7.97 532.516 447.364 Tm
(1)Tj
9.963 0 0 9.963 309.316 436.932 Tm
[(va)15.1(lu)18.8(es)13.9(.)-239.4(T)12.2(hu)15.5(s,)-230(th)18.8(e)-245.9(a)0(u)20.8(t)0(h)18.9(o)0(r)13.9(s)-241(ca)20.4(nn)15.5(ot)-231.5(de)20.8(du)15.5(ce)-230(wi)14.9(th)-231.5(an)15.1(y)-239.8(c)0(e)14.7(r)0(t)17.3(a)0(i)18.5(n)0(t)18.8(y)]TJ
T*
[(a)-285.7(c)0(o)20.8(n)0(c)15.1(l)0(u)18.8(s)0(i)17.7(o)0(n)-274.7(f)0(r)18(o)0(m)-272.1(t)0(h)13.2(e)-280(co)15.1(rr)18(el)18.4(at)18.5(io)18.9(n)-285.3(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)-279.6(ba)15.1(se)19.6(li)16.5(ne)-269.4(FE)12.2(V)]TJ
7.97 0 0 7.97 530.079 426.444 Tm
(1)Tj
9.963 0 0 9.963 533.99 426.444 Tm
(,)Tj
-22.5516 -1.0471 TD
-0.0165 Tc
[(a)-16.5(n)-1.4(d)-341.6(m)-16.5(et)-16.5(ha)-16.5(ch)-16.5(o)4.7(l)-16.5(in)-16.5(e)-331.4(o)-16.5(r)-332.6(a)-16.5(ce)-16.5(ta)-16.5(ld)-16.5(eh)-16.5(y)4.7(d)-16.5(e)-331.4(r)-16.5(es)-16.5(p)3.5(o)-16.5(ns)-16.5(iv)-16.5(e)4.3(n)-16.5(es)-16.5(s.)]TJ
1.0015 -1.0527 TD
0 Tc
[(On)-238.8(th)18.8(e)-245.9(o)0(t)18.9(h)0(e)15.1(r)-247.1(ha)20.8(nd)15.5(,)-245.1(t)13.9(he)-240.9(pr)19.6(op)15.5(or)19.6(ti)16.5(on)-234.8(of)-236.4(su)20(bj)18.9(ec)14.7(ts)-238.4(w)12.4(i)0(t)16.5(h)-245.5(AH)13.4(R)]TJ
-1.0015 -1.0471 TD
[(to)-368.1(me)17.7(th)13.2(ac)20.4(ho)15.5(li)16.5(ne)-366.1(w)12.4(a)0(s)-367.3(l)0(o)18.9(w)0(e)11.2(r)-372.2(am)17.7(on)15.5(g)-376.3(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)-363.6(w)0(i)14.9(t)0(h)-368.1(c)0(h)20.8(r)0(o)13.9(n)0(i)18.8(c)]TJ
0 -1.0528 TD
[(br)13.9(on)21.2(ch)15.1(it)16.5(is)-266.9(al)12.8(on)21.2(e)-280(t)0(h)18.9(a)0(n)-275.1(i)0(n)-265.7(t)0(h)13.2(o)0(s)20(e)-280(wi)14.9(th)-271.4(C)11.6(O)0(P)18.1(D)0(.)-272.5(T)0(h)17.1(i)0(s)-272.6(c)0(a)20.4(n)-279.6(pr)13.9(ob)21.2(-)]TJ
0 -1.0471 TD
[(ab)15.1(ly)-351(be)-354.7(ex)20.8(pl)13.2(ai)18.5(ne)20.8(d)-365(a)0(s)-350.3(a)-359.7(co)15.1(ns)20(eq)15.1(ue)20.8(nc)15.1(e)-359.7(o)0(f)-350.2(d)0(i)13.2(f)20.4(fe)19.2(re)13.5(nt)-351(ba)20.8(se)13.9(li)16.5(ne)]TJ
0 -1.0528 TD
[(FE)17.9(V)]TJ
7.97 0 0 7.97 327.742 363.685 Tm
(1)Tj
9.963 0 0 9.963 334.375 363.685 Tm
[(va)20.8(lu)13.2(es)-253.5(be)15.1(tw)20.6(ee)14.7(n)-262.5(b)0(o)15.5(t)0(h)-254.3(g)0(r)19.6(o)0(u)15.5(p)0(s)20(,)-262.1(th)13.2(e)-262.9(v)0(a)20.8(l)0(u)13.2(e)0(s)-253.5(b)0(e)20.8(i)0(n)13.2(g)-262.5(lo)18.9(we)16.9(r)]TJ
-2.5152 -1.0471 TD
[(in)-260(th)18.9(e)-268.6(C)11.6(OP)18.1(D)-266.5(g)0(r)13.9(o)0(u)21.2(p)0(.)-257.2(B)0(y)-256.6(c)0(o)15.1(n)0(t)18.9(r)0(a)19.2(s)0(t)-261.2(t)0(h)18.8(e)0(r)19.2(e)-268.6(w)12.4(e)0(r)13.5(e)-262.9(no)-257.6(di)18.9(f)14.7(f)0(e)19.2(r)0(e)19.2(n)0(c)15.1(e)0(s)]TJ
0 -1.0527 TD
[(in)-390.9(th)18.9(e)-393.8(p)0(r)19.6(o)0(p)15.5(o)0(r)19.6(t)0(i)16.5(o)0(n)-388.5(o)0(f)-384.4(s)0(u)14.4(b)0(j)18.9(e)0(c)20.4(t)0(s)-386.4(w)0(i)14.9(t)0(h)-385.2(A)0(H)13.4(R)-392.4(to)-390.9(ac)20.4(et)18.4(al)12.8(de)20.8(hy)15.5(de)]TJ
T*
[(am)12(on)21.2(g)-393.4(t)0(h)18.9(e)-393.8(tw)14.9(o)-387.7(g)0(r)13.9(o)0(u)21.2(p)0(s)14.4(.)-387.3(Th)17.1(is)-386.4(ma)17.7(y)-393.4(i)0(m)15.7(p)0(l)18.9(y)-393.4(t)13.9(h)0(a)15.1(t)-390.1(in)-385.2(su)20(bj)13.2(ec)20.4(ts)]TJ
0 -1.0471 TD
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