%PDF-1.2
%����
2 0 obj
<<
/Length 16857
>>
stream
0 g
/GS2 gs
1 i 
391.011 629.178 0.51 -274.45 re
f
BT
/F1 1 Tf
14.944 0 0 14.944 67.805 709.398 Tm
0.0208 Tc
[(Bronchoalveolar)-334(l)2.1(avage)-330.1(f)-2.8(luid)-332.6(urea)-330.1(as)-333.9(a)-333.9(m)-0.9(easure)-333.9(of)-332.9(pulmonary)]TJ
7.3977 -1.0357 TD
[(permeability)-334(i)-1.8(n)-332.7(h)1.2(ealthy)-334(s)-0.1(mokers)]TJ
/F2 1 Tf
10.959 0 0 10.959 142.413 656.56 Tm
0 Tc
[(C.)-330.5(Ward)]TJ
/F3 1 Tf
3.7092 0 TD
0 Tw
(*)Tj
/F2 1 Tf
0.5018 0 TD
[(,)-334.6(F)0(.)-331.1(Thien)]TJ
/F3 1 Tf
4.3299 0 TD
(*)Tj
/F2 1 Tf
0.4966 0 TD
[(,)-334.6(J)0(.)-331.2(Secombe)]TJ
/F3 1 Tf
5.9285 0 TD
(**)Tj
/F2 1 Tf
0.9984 0 TD
[(,)-334.6(S)0(.)-330.8(Gollant)]TJ
/F3 1 Tf
5.049 0 TD
(*)Tj
/F2 1 Tf
0.4966 0 TD
[(,)-334.6(E.H.)-330.2(Walters)]TJ
/F3 1 Tf
6.2751 0 TD
(*)Tj
/F4 1 Tf
8.966 0 0 8.966 58.28 619.71 Tm
[(Br)27.9(onchoalveolar)-415.9(lavage)-416.2(fluid)-415.6(ur)31.4(ea)-416.1(as)-417.5(a)-416.8(measur)29.2(e)-410.3(o)0(f)-418.7(pulmonary)-419.4(permeability)-418.2(in)-412.4(healthy)]TJ
0 -1.0559 TD
[(smokers.)-378.8(C.)-380.2(W)82.2(a)0(r)31.4(d)0(,)-381.8(F)123.5(.)-376(Thien,)-380.5(J.)-381.6(Secombe,)-381.3(S.)-381.8(Gollant,)-376.5(E.H.)-384.6(W)82.2(alters.)]TJ
/F5 1 Tf
27.7323 0 TD
(#)Tj
/F4 1 Tf
0.999 0 TD
[(ERS)-378.5(Journals)-379.8(Ltd)]TJ
-28.7313 -1.0559 TD
(2000.)Tj
/F6 1 Tf
T*
[(ABSTRACT)66.7(:)-392.5(The)-399.9(effects)-398.2(of)-398.3(cigarette)-390.8(smoking)-396(on)-395.9(blood)-401.7(to)-392(airway)-400.7(pulmonary)-398.4(per)28.7(-)]TJ
T*
[(meability)-286.9(to)-284.5(the)-282.3(low-molecular)28.5(-weight)-286.9(solute)-284.4(urea)-268(were)-278.8(investigated,)-279.6(in)-284.5(an)-282.1(attempt)-289(to)]TJ
T*
[(evaluate)-332.5(its)-338.1(use)-333.1(as)-335.3(a)-328.3(dilution)-341.2(marker)-330.4(for)-334.3(bronchoalveolar)-327(lavage)-334.2(\(BAL\))-334.6(studies.)]TJ
0.999 -1.0496 TD
[(Five)-250.2(healthy)-256(normal)-251(smokers)-250.3(who)-253.3(smoked)-248.4(a)-252.4(cigarette)-245.4(10)-251.9(min)-252.8(prior)-250.9(to)-246.6(undergoing)-256.7(a)]TJ
-0.999 -1.0559 TD
(3)Tj
/F7 1 Tf
0.4995 0 TD
(6)Tj
/F6 1 Tf
0.999 0 TD
[(60)-321.5(mL)-314(bronchoalveolar)-308.1(lavage)-321.6(\(BAL\),)-318.5(and)-318.1(five)-317.2(nonsmokers)-321.8(who)-316.5(also)-317.7(underwent)]TJ
-1.4985 -1.0559 TD
[(BAL)-327.4(but)-331.7(without)-330(cigarette)-321.3(smoke)-332.6(exposur)12(e)-328.1(were)-323.1(studied.)-328.2(Five)-332.4(minutes)-327.2(before)-318.3(bron-)]TJ
T*
[(choscopy)50.4(,)-426.6(4)-423.1(MBq)]TJ
6.725 0 0 5.977 129.997 538.526 Tm
(3)Tj
8.966 0 0 8.966 133.342 534.557 Tm
[(H-water)-433(and)-425.6(1)-423.1(MBq)]TJ
6.725 0 0 5.977 218.324 538.526 Tm
0.0001 Tc
(14)Tj
8.966 0 0 8.966 225.071 534.557 Tm
0 Tc
[(C-ur)12.1(ea)-428.7(wer)11.3(e)-429.2(injected)-426.7(intravenously)-431.9(and)]TJ
-18.602 -1.0559 TD
[(biochemical)-377.8(urea)-369.2(assays)-379.9(and)-375(an)-377(indirect)-364.9(radiotracer)-380.9(method)-381(wer)11.3(e)-378.7(used)-375.5(to)-379.3(evaluate)]TJ
T*
[(permeability)45.3(.)]TJ
0.999 -1.0559 TD
[(It)-424.8(was)-420.3(shown)-416.4(that)-422.1(the)-421.4(smoking)-427.6(gr)13.9(oup)-419.3(had)-419.3(less)-426.1(urea)-407.1(in)-423.6(their)-422.6(BAL)-422.2(supernatants)]TJ
-0.999 -1.0559 TD
[(compar)10.8(ed)-345.1(to)-347.7(nonsmokers)-347.1(the)-345.6(r)13.4(esults)-348.8(using)-346(the)-345.6(radiotracer)-349.3(method)-343.1(being)-344.5(significant)]TJ
T*
(\(p)Tj
/F8 1 Tf
0.8726 0 TD
(<)Tj
/F6 1 Tf
0.5564 0 TD
[(0.005\).)-592.3(Using)-590.9(both)-596.8(methods,)-593.2(it)-590.4(was)-597.3(shown)-593.5(that)-592.8(levels)-596.8(of)-594.3(ur)15.3(ea)-593.1(increased)-583.3(in)]TJ
-1.429 -1.0559 TD
[(sequentially)-308.3(aspirated)-306.5(aliquots)-303.5(in)-303.5(both)-299.6(groups.)-295.1(The)-305(median)-300.2(directly)-296.7(assayed)-307(levels)-306(of)]TJ
T*
[(urea)-419.7(in)-429.9(the)-434.1(smokers)-433.7(rose)-422.3(as)-430.1(follows:)-437.1(aliquot)-429.3(1)-429.5(0.05)]TJ
/F8 1 Tf
23.0217 0 TD
(m)Tj
/F6 1 Tf
0.5754 0 TD
(mol)Tj
/F9 1 Tf
1.5934 0.2213 TD
(.)Tj
/F6 1 Tf
0.2719 -0.2213 TD
(mL)Tj
6.725 0 0 5.977 299.905 472.252 Tm
(-1)Tj
8.966 0 0 8.966 305.461 468.283 Tm
[(,)-432.9(\(range)-432.3(0.03\2610.14\),)]TJ
-27.5679 -1.0559 TD
[(aliquot)-321.8(2)-315.7(0.10)]TJ
/F8 1 Tf
6.1712 0 TD
(m)Tj
/F6 1 Tf
0.5754 0 TD
(mol)Tj
/F9 1 Tf
1.5934 0.2213 TD
(.)Tj
/F6 1 Tf
0.2719 -0.2213 TD
(mL)Tj
6.725 0 0 5.977 148.819 462.784 Tm
(-1)Tj
8.966 0 0 8.966 157.266 458.816 Tm
[(\(0.07\2610.17\),)-315.9(aliquot)-321.8(3)-315.7(0.12)]TJ
/F8 1 Tf
11.3876 0 TD
(m)Tj
/F6 1 Tf
0.5691 0 TD
(mol)Tj
/F9 1 Tf
1.5934 0.2213 TD
(.)Tj
/F6 1 Tf
0.2719 -0.2213 TD
(mL)Tj
6.725 0 0 5.977 294.52 462.784 Tm
(-1)Tj
8.966 0 0 8.966 302.967 458.816 Tm
[(\(0.06\2610.23\))-319.3(\(p)]TJ
/F8 1 Tf
5.8361 0 TD
(<)Tj
/F6 1 Tf
0.5501 0 TD
(0.05\).)Tj
-33.6758 -1.0559 TD
[(This)-422.1(led)-429.2(to)-423.6(significantly)-426.6(increased)-412.6(calculated)-427.1(levels)-426.1(of)-423.6(epithelial)-432.1(lining)-424.9(fluid)-424(in)-423.6(the)]TJ
T*
[(sequential)-389.1(aliquots)-385.7(\(p)]TJ
/F8 1 Tf
9.2757 0 TD
(<)Tj
/F6 1 Tf
0.5501 0 TD
[(0.05\).)-384.1(In)-384.5(addition,)-386(there)-375.7(wer)11.3(e)-385(large)-385.1(but)-382.3(variable)-384.5(amounts)-388.2(of)]TJ
-9.8258 -1.0559 TD
[(labelled)-530.9(water)-526.1(detected)-531.6(in)-524.8(both)-527.2(subject)-533.7(gr)13.9(oups)-527.4(indicating)-529.7(a)-530.6(complex)-528.5(interaction)]TJ
T*
[(between)-338.6(the)-332.9(BAL)-333.7(proced)12.9(ure)-325.4(and)-330.8(the)-339.2(cir)12.2(culation.)]TJ
0.999 -1.0559 TD
[(Changing)-673.9(urea)-666.3(measure)10.3(ments)-675(during)-677.7(the)-674.4(br)15.3(onchoalveolar)-677.5(lavage)-675.7(proced)12.9(ure)]TJ
-0.999 -1.0559 TD
[(confound)-294.5(the)-295(use)-295.2(of)-297.1(the)-295(urea)-280.6(\(epithelial)-299.7(lining)-298.4(fluid\))-298(method)-292.5(for)-296.4(normalizing)-295.9(dilution)]TJ
0 -1.0496 TD
[(factors.)-514.2(The)-513.7(use)-510.2(of)-512.1(epithelial)-520.6(lining)-513.4(fluid)-512.5(determinations)-514.7(in)-518.4(smokers)-509.6(ignores)-504(the)]TJ
0 -1.0559 TD
[(additional)-232.7(and)-235.9(pr)15.3(obably)-236.8(complex)-231.3(permeability)-239.2(changes.)-231.2(The)-235.5(pr)15.3(esent)-238(data)-231.5(suggest)-232.1(that)]TJ
T*
[(acute)-628.8(exposur)12(e)-625.2(t)0(o)-625.9(cigarette)-618.5(smoke)-629.7(in)-625.9(smokers)-629.7(may)-624.9(decre)11.2(ase)-625.4(blood)-629.3(to)-625.9(airway)]TJ
T*
[(permeability)45.3(.)]TJ
/F4 1 Tf
T*
[(Eur)-331.9(Respir)-333.8(J)-334.4(2000;)-333.5(15:)-334.6(285\261290.)]TJ
/F3 1 Tf
7.97 0 0 7.97 401.499 620.731 Tm
[(*Dept)-598(of)-607.7(Respiratory)-597.6(Medicine,)-601.8(Alfred)]TJ
0 -1.067 TD
[(Hospital)-355.8(and)-355.5(Monash)-349.4(University)-351.8(Medical)]TJ
0 -1.0599 TD
[(School,)-213.1(and)-220.3(Dept)-223.1(of)-223.6(Biochemis)10(try)-223.9(**Mon-)]TJ
T*
[(ash)-292.6(Medical)-292(Centre,)-297.4(Melbour)14.1(ne,)-299.6(Australia)]TJ
0 -2.1268 TD
[(Corresponde)11.8(nce:)-333.4(E.H.)-326.1(W)76.3(alters)]TJ
0 -1.0598 TD
[(Dept)-329.8(of)-330.3(Respiratory)-327.3(Medicine)]TJ
0 -1.067 TD
[(Alfred)-325.9(Hospital)-327.3(Prahran)-329.9(Melbourne)]TJ
0 -1.0599 TD
[(V)56.5(ictoria)-332(3181)-325.9(Australia)]TJ
0 -1.067 TD
[(Fax:)-325.1(61)-330.1(395298498)]TJ
0 -2.1197 TD
[(Keywords)11.5(:)-334.6(Bronchoalve)11.8(olar)-334.6(lavage)]TJ
0 -1.067 TD
[(epithelial)-329.3(lining)-328.9(fluid)]TJ
0 -1.0599 TD
[(permeabil)9.6(ity)]TJ
T*
(smoking)Tj
0 -1.067 TD
(urea)Tj
0 -2.1197 TD
[(Received:)-327.9(Novembe)14(r)-332.4(3)-332.2(1998)]TJ
0 -1.067 TD
[(Accepted)-275.6(after)-281.8(revision)-272.8(September)-270.3(7)-282.4(1999)]TJ
0 -2.1268 TD
[(Supported)-257.8(by)-259(the)-265.4(Alfred)-261.9(Hospital)-256.2(Founda-)]TJ
0 -1.0599 TD
[(tion)-330.7(and)-327(GlaxoW)75.9(ellcome,)-327.7(Australia)9.9(.)]TJ
9.963 0 0 9.963 68.258 315.893 Tm
[(An)-261.5(in)13.2(cr)19.2(ea)20.4(si)12(ng)-257.6(bo)15.5(dy)-263.3(of)-259.2(li)16.5(te)18.4(ra)13.5(t)13.9(u)0(r)14(e)-268.6(su)14.4(gg)21.2(es)13.9(ts)-261.2(th)18.9(at)-260.4(th)13.2(e)-268.6(i)0(n)18.8(t)0(e)12.8(g)0(-)]TJ
-1.0015 -1.0755 TD
[(ri)17.3(ty)-305.5(of)-304.7(th)18.8(e)-314.1(p)0(u)15.5(l)0(m)15.7(o)0(n)21.2(a)0(r)13.5(y)-313.7(bl)18.9(oo)15.5(d/)18.9(ai)18.4(r)-315.3(b)0(a)20.8(r)0(r)12.4(i)0(e)18.4(r)-315.3(is)-301(al)12.8(te)18.4(re)19.2(d)-313.7(i)0(n)-305.5(a)-314.1(di)13.2(v-)]TJ
T*
[(er)19.2(se)-202.3(ra)19.2(ng)15.5(e)-206(o)0(f)-196.6(c)0(i)18.4(r)0(c)19.2(u)0(m)12.4(s)0(t)17.7(a)0(n)20.8(c)0(e)14.7(s)0(.)-195.8(T)0(h)17.1(e)0(s)19.6(e)-206(in)13.2(cl)18.5(ud)21.2(e)-206(i)0(n)13.2(t)0(e)18.4(n)0(s)20(e)-206(ex)15.1(er)19.2(ci)12.8(se)]TJ
T*
[(in)-487.6(el)18.4(it)16.5(e)-496.2(a)0(t)18.5(h)0(l)18.9(e)0(t)12.8(e)0(s)-486.8([)0(1)19.6(])-508.8(and)-503.5(smok)-7.4(ing)-505.4(in)-510.4(otherwi)-10.3(se)-503.9(norm)-7.8(al)]TJ
T*
[(subje)-7.8(cts)-398.9([2])-398.1(as)-395.8(well)-399.1(as)-401.5(airway)-400.3([3])-398.1(a)-6.9(n)0(d)-394.2(parench)-8.2(ymal)-401.6([4])]TJ
0 -1.0698 TD
[(inflamm)-12.7(atory)-338.2(disea)-8.2(se.)]TJ
1.0015 -1.0527 TD
[(Th)17.1(e)-308.5(p)0(r)19.6(e)0(c)14.7(i)0(s)17.7(e)-308.5(me)17.7(ch)15.1(an)20.8(is)17.7(ms)-301.8(un)21.2(de)15.1(rl)17.3(yi)18.9(ng)-297.4(in)13.2(cr)19.2(ea)14.7(se)19.6(d)-308.1(p)0(u)21.2(l)0(m)15.7(o)0(n)15.5(-)]TJ
-1.0015 -1.0755 TD
[(ar)19.2(y)-365(p)0(e)15.1(r)0(m)16.5(e)0(a)20.4(b)0(i)18.9(l)0(i)16.5(t)0(y)-356.7(a)0(r)19.2(e)-365.4(no)21.2(t)-367.3(f)0(u)19.6(l)0(l)16.5(y)-365(un)21.2(de)15.1(rs)18.4(to)18.9(od)15.5(.)-358.9(H)0(o)17.3(w)0(e)11.2(v)0(e)20.8(r)37.5(,)-358.9(e)0(v)15.1(i)0(-)]TJ
T*
[(de)15.1(nc)20.8(e)-251.6(i)0(n)18.9(d)0(i)13.2(c)0(a)20.4(t)0(e)18.4(s)-252.3(th)18.9(at)-243.3(ex)15.1(tr)17.3(av)20.8(as)14(at)18.4(io)18.9(n)-251.2(o)0(f)-242.1(s)0(o)20(l)0(u)13.2(t)0(e)18.4(s)-252.3(oc)20.8(cu)15.1(rs)-243.3(la)18.4(r)20.4(g)0(e)15.1(l)0(y)]TJ
T*
[(th)18.9(ro)13.9(ug)21.2(h)-228.4(p)0(a)20.8(r)0(a)13.5(c)0(e)20.4(l)0(l)16.5(u)0(l)18.9(a)0(r)-219.8(r)0(o)19.6(u)0(t)18.9(e)0(s)13.9(,)-222.3(an)15.1(d,)-217.4(i)13.9(n)0(i)13.2(t)0(i)16.5(a)0(l)18.4(l)0(y)81.4(,)]TJ
/F4 1 Tf
16.1441 0 TD
[(vi)12.8(a)]TJ
/F3 1 Tf
1.4169 0 TD
[(th)18.9(e)-228.8(f)0(o)19.6(r)0(m)16.5(a)0(t)18.4(i)0(o)13.2(n)]TJ
-17.561 -1.0755 TD
[(of)-162.5(ga)15.1(ps)-162.1(in)-157.6(th)13.2(e)-171.9(e)0(n)20.8(d)0(o)15.5(t)0(h)18.9(e)0(l)18.4(i)0(u)18.9(m)0(.)-163.6(T)0(h)17.1(e)0(s)13.9(e)-166.2(0.)15.9(1\261)15.5(3)]TJ
/F8 1 Tf
15.4043 0 TD
(m)Tj
/F3 1 Tf
0.5691 0 TD
[(m)-168.9(g)0(a)15.1(p)0(s)20(,)-171.1(fo)19.6(rm)10.8(ed)-161.3(at)]TJ
-15.9734 -1.0755 TD
[(th)18.9(e)-217.4(b)0(o)21.2(r)0(d)19.6(e)0(r)13.5(s)-212.5(be)15.1(t)13.9(w)0(e)11.2(e)0(n)-201.1(a)0(d)15.1(j)0(a)18.4(c)0(e)20.4(n)0(t)-208.8(c)0(e)20.4(l)0(l)16.5(s)0(,)-201.5(c)0(a)14.7(n)-211.3(op)15.5(en)-201.1(up)-206.4(wi)14.9(th)18.9(in)-203.1(se)13.9(c-)]TJ
0 -1.0698 TD
[(on)15.5(ds)20(,)-233.7(f)0(o)19.6(r)-230(ex)15.1(am)17.7(pl)18.9(e)-234.5(f)0(o)19.6(l)0(l)16.5(o)0(w)17.3(i)0(n)18.9(g)-234.1(an)-223.9(in)18.9(fl)17.3(am)17.7(ma)12(to)18.9(ry)-225.1(st)17.7(im)15.7(ul)18.9(us)-219([5)13.9(].)]TJ
0 -1.0755 TD
[(Their)-490.3(revers)-9.8(ible)-491.9(formati)-11.1(on)-485.2(leads)-491.9(to)-487.6(leakag)-8.2(e)-484.9(o)0(f)-486.8(plasm)-10.9(a)]TJ
T*
[(const)-7.8(ituents)-378.3(into)-377.7(the)-375(perivascul)-10.7(ar)-373.4(connect)-8.9(ive)-375(tissue,)-382.4(and)]TJ
T*
[(then)-483.8(through)-487.3(deformabl)-10.7(e)-479.2(tight)-483.3(junctions)-487.9(in)-481.9(the)-477.4(a)-6.9(irway)]TJ
T*
[(epithe)-10.1(lium,)-489.3(leading)-494.6(to)-487.6(the)-488.8(emergence)-485.9(of)-486.8(some)-491.5(plasm)-10.9(a)]TJ
T*
[(const)-7.8(ituents)-440.9(into)-440.3(the)-437.6(airway)-440.1(lume)-9(n)-433.3([6].)-438.3(Thus,)-435.5(the)-437.6(term)]TJ
T*
[(pulmo)-9.3(nary)-335.1(perm)-8.2(eability)51.9(,)-336.1(a)0(s)-333.2(used)-340.4(in)-339.7(this)-339.1(paper)27.9(,)-336.1(descri)-10.5(bes)]TJ
T*
[(movem)-10.5(ent)-454.6(of)-458.4(solut)-9.8(es)-458.4(through)-458.9(a)-456.4(modul)-9.3(able)-461.5(barrier)-462.9(that)]TJ
25.1977 20.4006 TD
[(compr)-9(ises)-349.7(the)-346.5(pulm)-8.6(onary)-347.2(vascul)-9(ar)-345(endoth)-7.4(elium,)-348.2(the)-346.5(res-)]TJ
0 -1.0755 TD
[(pirat)-10.6(ory)-333.9(epit)-8.2(helium)-337.3(and)-338.4(the)-335.1(inte)-8.2(rvening)-339.8(interstiti)-13.7(um.)]TJ
1.0015 -1.0471 TD
[(Pu)16.3(lm)15.7(on)15.5(ar)19.2(y)-677.9(p)0(e)15.1(r)0(m)16.5(e)0(a)20.4(b)0(i)13.2(l)0(i)16.5(t)13.9(y)-683.6(c)0(a)20.4(n)-683.6(be)-667.7(es)13.9(t)13.9(i)0(m)15.7(a)0(t)12.8(e)0(d)-667.7(u)0(s)14.4(i)13.9(ng)-673(a)]TJ
-1.0015 -1.0755 TD
[(nu)15.5(mb)18.1(er)-418.9(of)-412.8(ap)20.8(pr)13.9(oa)20.8(ch)15.1(es)19.6(.)-427.2(R)11.6(es)13.9(pi)18.9(ra)19.2(to)18.9(ry)-418.5(cl)18.4(ea)20.4(ra)13.5(nc)20.8(e)-428(o)0(f)-412.8(i)0(n)18.9(h)0(a)15.1(l)0(e)18.4(d)]TJ
T*
[(ra)13.5(di)18.9(oa)15.1(er)19.2(os)20(ol)13.2(s)-241(h)0(a)15.1(s)-241(be)15.1(en)-235.2(wi)14.9(de)20.8(ly)-237.2(us)20(ed)-235.2(an)15.1(d)-245.5(t)0(h)18.9(e)-245.9(li)16.5(mi)15.7(ts)-232.7(an)15.1(d)-245.5(u)0(s)20(e)0(-)]TJ
T*
[(fu)13.9(ln)18.9(es)19.6(s)-343.4(o)0(f)-333.2(t)0(h)18.8(i)0(s)-329.5(t)0(e)12.8(c)0(h)20.8(n)0(i)18.9(q)0(u)15.5(e)-342.6(ha)20.8(ve)-332(be)15.1(en)-332(ex)20.8(te)12.8(ns)20(iv)18.9(el)18.5(y)-342.2(r)0(e)19.2(v)0(i)13.2(e)0(w)16.9(e)0(d)]TJ
T*
[([2)13.9(,)-432.9(7)0(\261)15.5(9)0(])19.6(.)-438.6(Ho)17.3(we)16.9(ve)20.8(r)37.5(,)-438.6(th)18.8(is)-426.2(me)17.7(th)13.2(od)-422.6(es)13.9(ti)16.5(ma)17.7(te)18.4(s)-434.4(m)0(o)12.4(v)0(e)20.8(m)0(e)17.7(n)0(t)-430.7(o)0(f)]TJ
T*
[(so)14.4(lu)18.8(te)18.4(s)-388.9(f)0(r)18(o)0(m)-380.3(t)0(h)18.8(e)-388.1(ai)18.4(rw)15.7(ay)-377.5(to)-379.5(th)18.9(e)-388.1(b)0(l)18.9(o)0(o)15.5(d)0(,)-376.7(w)0(h)17.3(e)0(r)13.5(e)0(a)20.4(s)-388.9(ph)21.2(ys)14.4(io)18.9(lo)18.8(-)]TJ
T*
[(gi)13.2(ca)20.4(ll)16.5(y)-308.1(a)0(n)15.1(d)-308.1(pa)20.8(th)13.2(ol)18.9(og)21.2(ic)12.8(al)18.5(ly)81.4(,)-307.7(i)0(t)-302.2(i)0(s)-301(m)0(o)18.1(v)0(e)20.8(m)0(e)12(n)0(t)-299.8(i)0(n)-299.8(t)0(h)18.9(e)-308.5(op)15.5(po)21.2(si)17.7(te)]TJ
T*
[(di)13.2(re)19.2(ct)18.4(io)18.9(n,)]TJ
/F4 1 Tf
4.0061 0 TD
[(i.)19.2(e.)]TJ
/F3 1 Tf
1.5023 0 TD
[(fr)18(om)-317.7(th)13.2(e)-325.5(b)0(l)18.9(o)0(o)15.5(d)-325.1(t)13.9(o)-330.8(t)13.9(h)0(e)-320.6(a)0(i)18.4(r)0(w)15.7(a)0(y)-314.9(l)0(u)18.8(m)0(e)12(n)0(,)-314.1(t)0(h)18.9(a)0(t)-317.3(i)0(s)]TJ
-5.5084 -1.0755 TD
[(im)15.7(po)15.5(rt)17.3(an)20.8(t.)-470.2(T)12.2(h)0(u)15.5(s)-474.3(ap)15.1(pr)19.6(oa)15.1(ch)20.8(es)-469.8(ba)20.8(se)13.9(d)-473.1(o)0(n)-468.2(i)0(n)18.9(j)0(e)18.4(c)0(t)18.4(i)0(n)13.2(g)-473.1(ra)19.2(di)13.2(ol)18.9(a-)]TJ
T*
[(be)15.1(ll)16.5(ed)-326.3(m)13.2(o)0(l)13.2(e)0(c)20.4(u)0(l)18.9(e)0(s)-327.5(i)0(n)18.8(t)0(o)-328.3(t)13.9(he)-326.3(va)15.1(sc)19.6(ul)18.9(ar)-327.9(co)20.8(mp)12.4(ar)19.2(tm)15.7(en)20.8(t)-338.9(a)0(n)20.8(d)-336.5(t)13.9(h)0(e)15.1(n)]TJ
0 -1.0698 TD
[(mo)12.4(ni)18.9(to)18.8(ri)17.3(ng)-354.3(th)13.2(ei)18.4(r)-366.6(a)0(p)20.8(p)0(e)15.1(a)0(r)19.2(a)0(n)15.1(c)0(e)-355.2(i)0(n)-356.7(t)0(h)18.8(e)-365.4(lu)18.8(ng)-354.3(ha)15.1(ve)-354.7(be)15.1(en)-354.8(us)20(ed)15.1(.)]TJ
0 -1.0755 TD
[(Ex)17.1(pe)15.1(ri)17.3(me)17.7(nt)18.9(s)-332(i)0(n)-322.6(a)0(n)15.1(i)0(m)15.7(a)0(l)18.4(s)-332([1)19.6(0])-333.2(and)-344.1(more)-343.9(limit)-10.8(ed)-337.7(studi)-9.8(es)-338.9(in)]TJ
T*
[(human)-7.4(s)-218.2([)0(1)31(1)0(])-219.4(have)-220.1(been)-220.1(carri)-10.2(ed)-218.2(out,)-215.6(wi)-7.8(th)-214.5(some)-224(of)-213.7(the)-221.3(latter)]TJ
T*
[(invol)-8.6(ving)-295.7(broncho)-7.3(alveolar)-298.2(lavage)-292.7([12\26114])-8.5(.)-290.6(The)-291.3(lit)-9.4(erature)]TJ
T*
[(on)-263.3(the)-266.8(effects)-258(of)-264.9(smoking)-268.1(on)-263.3(pulmonary)-270.5(perm)-8.2(eability)-266.8(has)]TJ
T*
[(predom)-9.7(inant)-9(ly)-544.5(indi)-7.8(cated)-553.7(an)-548.2(incre)-8.6(ase)-550.6([2],)-552.2(with)-552.3(studies)]TJ
T*
[(typi)-7.8(cally)-219.9(meas)-8.2(uring)-224(respirato)-11.1(ry)-219.4(clear)-9(ance)-220.5(from)-225.6(the)-215.6(lung)-221.7(to)]TJ
T*
[(the)-244.1(circulation.)-248.7(This)-238.4(finding)-245(is)-238.4(not)-238(unifo)-7.8(rm,)-240(however)22.5(,)-233.7([15,)]TJ
/F2 1 Tf
6.974 0 0 6.974 58.28 797.499 Tm
0.0001 Tc
[(Eur)-334.8(Respir)-337.8(J)-337.2(2000;)-339.7(15:)-330.1(285\261290)]TJ
0 -1.1462 TD
0 Tc
[(Printed)-341.4(i)0(n)-335.6(U)-0.1(K)-331.2(\261)-334.1(all)-337(rights)-335.9(r)0(e)-9.2(s)0(erved)]TJ
52.703 2.2844 TD
0.0001 Tc
(Copyright)Tj
/F5 1 Tf
5.928 0 0 5.928 457.909 806.456 Tm
0 Tc
(#)Tj
/F2 1 Tf
6.974 0 0 6.974 463.805 805.436 Tm
0.0001 Tc
[(ERS)-339.8(Journals)-337.8(L)0(td)-338.3(2000)]TJ
-4.4305 -1.1381 TD
[(European)-338.6(Res)-10.1(piratory)-336.9(Journal)]TJ
3.2843 -1.1462 TD
[(ISSN)-335.2(0903-1936)]TJ
ET
endstream
endobj
3 0 obj
<<
/ProcSet [/PDF /Text ]
/Font <<
/F1 4 0 R
/F2 5 0 R
/F3 6 0 R
/F4 7 0 R
/F5 8 0 R
/F6 9 0 R
/F7 10 0 R
/F8 11 0 R
/F9 12 0 R
>>
/ExtGState <<
/GS2 13 0 R
>>
>>
endobj
16 0 obj
<<
/Length 19462
>>
stream
BT
/F3 1 Tf
9.963 0 0 9.963 58.28 771.647 Tm
0 g
/GS2 gs
0 Tc
[(16],)-243.3(with)-239.4(a)-240.2(reported)-245.8(decreas)-9.7(e)-234.5(i)0(n)-237.2(diet)-8.2(hylene)-7.8(triamine)-246.4(penta-)]TJ
0 -1.0641 TD
[(acetic)-341(acid)-336.3(clear)-9(ance)-340(following)-343.9(passive)-341(smoking)-342.1([17].)]TJ
1.0015 -1.0527 TD
[(Un)17.3(de)15.1(rs)18.4(ta)18.4(nd)15.5(in)18.9(g)-370.7(t)0(h)18.9(e)-371.1(re)19.2(le)18.4(va)15.1(nc)20.8(e)-371.1(o)0(f)-361.6(c)0(h)15.1(a)0(n)20.8(g)0(e)15.1(s)-366.2(in)-362.4(pu)15.5(lm)15.7(on)21.2(ar)13.5(y)]TJ
-1.0015 -1.0698 TD
[(pe)15.1(rm)16.5(ea)20.4(bi)18.9(li)16.5(ty)-220.2(w)12.4(i)0(l)16.5(l)-225.1(al)18.4(so)-219(be)-212.5(he)15.1(lp)18.9(fu)19.6(l)-225.1(i)0(n)-220.2(t)0(h)18.9(e)-223.1(in)18.9(te)12.8(rp)19.6(re)19.2(ta)12.8(ti)22.2(on)-217.8(of)-213.7(th)13.2(e)]TJ
0 -1.0641 TD
[(la)18.4(r)20.4(g)0(e)-445.8(a)0(n)20.8(d)-450.3(ra)19.2(pi)13.2(dl)18.9(y)-450.3(g)0(r)19.6(o)0(w)17.3(i)0(n)18.9(g)-450.3(li)16.5(te)18.4(ra)13.5(t)13.9(u)0(r)14(e)-450.7(on)-439.7(br)19.6(on)15.5(ch)20.8(oa)15.1(lv)18.9(eo)15.1(la)18.4(r)]TJ
0 -1.0698 TD
[(la)18.4(va)15.1(ge)-371.8(\(B)14.9(AL)13.2(\))-383.6([)0(1)19.6(8].)-390.5(A)-391.7(fundam)-9.7(entally)-400.2(imp)-7.8(ortant)-398.3(issu)-7.8(e)-393.8(i)0(n)]TJ
0 -1.0641 TD
[(such)-380.2(wor)-7.8(k,)-376.7(which)-380.4(rema)-8.6(ins)-381.4(controversi)-12.6(al,)-380.3(relates)-384(to)-379.5(how)]TJ
0 -1.0698 TD
[(BAL)-339.4(resul)-9.4(ts)-335.2(shoul)-7.4(d)-330.8(b)-6.5(e)-331.2(expres)-8.2(sed.)-340(Some)-341.6(continue)-341.7(to)-339.7(use)]TJ
0 -1.0641 TD
[(BAL)-419.1(fluid)-414.2(denom)-7.4(inat)-8.2(ors)-414.8(of)-412.8(dilutio)-9.2(n,)-410.9(using)-417.1(const)-7.8(ituents)]TJ
0 -1.0698 TD
[(such)-357.5(as)-355.9(album)-9.7(in)-351([19],)-359.4(tota)-8.2(l)-350.3(p)-6.5(rotein)-358.5([20])-359.1(or)-355.9(urea)-358.3([21].)-359.4(In)]TJ
0 -1.0641 TD
[(particula)-11.1(r)31.8(,)-341.8(the)-340.8(urea)-346.9(meth)-9(od)-337.3(for)-346.9(calculatin)-13.1(g)-336.5(epit)-8.2(helial)-342.6(lin-)]TJ
0 -1.0698 TD
[(ing)-317.7(fluid)-317.5(\(ELF\))-321.7(volume)-317.8(as)-316.1(a)-314.2(means)-316.2(of)-316.1(expres)-8.2(sing)-319.6(results)]TJ
T*
[(\(amo)-8.2(unt)-420.1(of)-424.2(solute)-426.3(per)-419.7(mil)-10.2(lilitre)-429(ELF\))-421.8(rema)-8.6(ins)-421.3(in)-419.3(wi)-7.8(de-)]TJ
0 -1.0641 TD
[(spread)-321.2(use)-316.9(in)-322.6(a)-314.2(signifi)-9.6(cant)-319.2(numbe)-7.4(r)-315.3(o)0(f)-316.1(centr)-8.6(es)-316.1(for)-318.5(diver)-8.2(se)]TJ
0 -1.0698 TD
[(patien)-10.1(t)-338.9(groups)-348.8(and)-349.8(analyses)-347.8([22\26124])-8.5(.)-341.8(The)-348.2(continu)-10.5(ed)-343.4(use)]TJ
0 -1.0641 TD
[(of)-503.9(the)-505.8(urea)-506.2(meth)-9(od,)-502.7(however)22.5(,)-501.2(i)0(s)-505.9(i)0(n)-504.7(spite)-505.3(of)-503.9(literat)-11.6(ure)]TJ
0 -1.0698 TD
[(indica)-10.1(ting)-423.2(that)-429.3(the)-426.2(assumpti)-11.1(ons)-424.6(underlying)-429.8(its)-429.3(rationale)]TJ
0 -1.0641 TD
[(are)-562.4(incor)-8.2(rect)-559.8([25\26127])-8.5(.)-558.1(Many)-568.8(such)-562.3(BAL)-561.3(studie)-10.9(s)-559.6(have)]TJ
0 -1.0698 TD
[(includ)-9.7(ed)-337.7(smokers,)-343.3(and)-338.4(smok)-7.4(ing)-340.4(itself)-345(has)-339.6(a)-336.9(major)-341.4(effect)]TJ
0 -1.0641 TD
[(upon)-242.1(c)-6.9(alculated)-248.9(ELF)-243.1(volum)-9.3(e,)-240.6(alth)-8.2(ough)-242.1(the)-244.1(reason)-247.2(for)-244.5(this)]TJ
0 -1.0698 TD
[(is)-335.2(not)-334.7(clear)-339.1([28].)]TJ
1.0015 -1.0471 TD
[(In)19.6(tr)17.3(av)15.1(en)15.1(ou)21.2(sl)17.7(y)-319.4(i)0(n)18.9(j)0(e)18.4(c)0(t)18.4(e)0(d)-309.2(u)0(r)13.9(e)0(a)-303.9(a)0(n)15.1(d)-319.4(w)12.4(a)0(t)12.8(e)0(r)-305.1(l)0(a)18.5(b)0(e)15.1(l)0(s)-306.7(w)0(e)16.9(r)0(e)-310.8(u)0(s)20(e)0(d)]TJ
-1.0015 -1.0698 TD
[(to)-271.4(st)17.7(ud)15.5(y)-279.6(p)0(u)21.2(l)0(m)15.7(o)0(n)15.5(a)0(r)19.2(y)-279.6(pe)15.1(rm)16.5(ea)14.7(bi)18.9(li)16.5(ty)-271.4(fr)18(om)-272.1(th)18.9(e)-280(b)0(l)13.2(o)0(o)21.2(d)-279.6(to)-271.4(th)13.2(e)-280(a)0(i)18.4(r)]TJ
T*
[(co)15.1(mp)18.1(ar)19.2(tm)15.7(en)15.1(t)-589.3(i)0(n)-584.3(s)0(m)16.9(o)0(k)15.5(e)0(r)19.2(s)0(.)-582.8(T)0(h)17.1(e)-593(wo)17.3(rk)-583.6(ex)15.1(te)18.4(nd)15.5(s)-588.1(p)0(r)14(e)0(v)20.8(i)0(o)18.9(u)0(s)]TJ
0 -1.0641 TD
[(in)18.9(ve)15.1(st)17.7(ig)18.9(at)18.5(io)18.9(ns)-264.5(in)18.9(to)-260(th)18.9(e)-268.6(a)0(p)15.1(p)0(l)18.9(i)0(c)18.4(a)0(b)15.1(i)0(l)16.5(i)0(t)16.5(y)-268.2(of)-259.2(th)18.9(e)-274.3(u)0(r)19.6(e)0(a)-258.4(m)0(e)12(t)0(h)18.9(o)0(d)-257.6(f)0(o)13.9(r)]TJ
0 -1.0698 TD
[(es)19.6(ti)16.5(ma)17.7(ti)16.5(ng)-314.5(EL)13(F)-324.3(a)0(n)20.8(d)-325.1(th)18.9(e)-325.5(e)0(x)15.1(p)0(r)19.6(e)0(s)19.6(s)0(i)17.7(o)0(n)-314.5(o)0(f)-316.1(B)0(A)12.6(L)-323.6(re)19.2(su)14.4(lt)22.2(s.)]TJ
/F6 1 Tf
9.5544 -4.046 TD
(Methods)Tj
/F3 1 Tf
-8.5529 -2.0998 TD
[(Pe)15.9(rm)16.5(is)17.7(si)17.7(on)-217.8(fo)19.6(r)-224.3(c)0(a)14.7(r)0(r)18(y)0(i)18.9(n)0(g)-217.8(o)0(u)15.5(t)-225.1(th)18.9(e)-223.1(s)0(t)17.7(u)0(d)15.5(y)-222.7(wa)16.9(s)-229.6(o)0(b)21.2(t)0(a)12.8(i)13.9(ne)15.1(d)-222.7(f)0(r)12.4(o)0(m)]TJ
-1.0015 -1.0698 TD
-0.0174 Tc
[(t)-17.4(h)1.5(e)-456.7(A)-17.4(lf)-17.4(re)-17.4(d)-446.1(J)-17.4(oi)-17.4(nt)-458.7(E)-5.2(t)-17.4(h)-4.2(i)-17.4(cs)-457.5(C)-5.8(o)-17.4(m)-5(m)-17.4(it)-17.4(te)-17.4(e.)-456(A)-17.4(l)-2.5(l)-453(v)-17.4(ol)-17.4(un)-17.4(te)-17.4(er)-17.4(s)-448.5(g)-17.4(av)-17.4(e)]TJ
T*
0 Tc
[(in)18.9(fo)13.9(rm)16.5(ed)-314.9(co)20.8(ns)14.4(en)20.8(t.)]TJ
/F4 1 Tf
0 -3.0957 TD
[(Subjec)-7.8(t)-333.2(g)0(r)31.4(o)0(u)-7.2(p)0(s)]TJ
/F3 1 Tf
1.0015 -1.6503 TD
[(Al)14.9(l)-509.6(s)0(u)14.4(b)0(j)18.9(e)0(c)20.4(t)0(s)-505.9(s)0(t)17.7(u)0(d)15.5(i)0(e)18.4(d)-512.9(we)16.9(re)-504.3(no)21.2(rm)16.5(al)-505.1(he)15.1(al)18.4(th)18.9(y)-512.9(v)0(o)15.5(l)0(u)18.9(n)0(t)18.9(e)0(e)14.7(r)0(s)]TJ
-1.0015 -1.0698 TD
[(wi)14.9(th)-294.1(no)21.2(rm)10.8(al)-294.5(lu)18.9(ng)-291.7(fu)13.9(nc)20.8(ti)16.5(on)15.5(,)-302(w)0(h)17.3(o)-302.4(un)15.5(de)20.8(rw)15.7(en)15.1(t)-304.7(a)-302.8(fu)19.6(ll)-296.5(me)17.7(di)18.9(ca)14.7(l)]TJ
0 -1.0641 TD
[(ex)15.1(am)17.7(in)18.9(at)18.5(io)18.8(n)-291(p)0(r)13.9(i)0(o)18.9(r)-292.6(to)-282.7(st)17.7(ud)21.2(y)67.5(.)-284.9(Fi)14(ve)-280.8(of)-282(th)18.9(e)-291.4(s)0(u)14.4(b)0(j)18.9(e)0(c)20.4(t)0(s)-283.9(h)0(a)15.1(d)-291(ne)20.8(ve)15.1(r)]TJ
0 -1.0698 TD
[(sm)16.9(ok)15.5(ed)-223.9(an)15.1(d)-234.1(f)0(i)17.3(v)0(e)-229.6(w)12.4(er)13.5(e)-234.5(a)0(c)14.7(t)0(i)22.2(v)0(e)-229.6(c)0(u)15.1(r)0(r)18(e)0(n)20.8(t)-236.5(ci)18.4(ga)15.1(re)19.2(tt)16.5(e)-234.5(s)0(m)11.2(o)0(k)21.2(e)0(r)19.2(s)0(.)-230(O)0(n)]TJ
0 -1.0641 TD
[(br)19.6(on)15.5(ch)15.1(os)20(co)20.8(py)78.1(,)-205.2(n)0(o)-189.3(e)0(v)15.1(i)0(d)18.9(e)0(n)15.1(c)0(e)-195.8(o)0(f)-190.9(l)0(o)13.2(c)0(a)20.4(l)0(i)16.5(z)0(e)14.7(d)-199.9(ai)18.4(rw)15.7(ay)-195.4(di)18.9(se)13.9(as)19.6(e)-206(w)0(a)16.9(s)]TJ
0 -1.0698 TD
[(fo)19.6(un)15.5(d.)]TJ
1.0015 -1.0527 TD
-0.0172 Tc
[(T)51.9(w)-4.8(o)-348(n)-17.2(on)-17.2(sm)-17.2(ok)-17.2(er)-17.2(s)-334.5(a)-17.2(nd)-342.3(o)-17.2(n)-1.7(e)-342.7(s)-17.2(mo)-17.2(ke)-17.2(r)-333.7(w)-17.2(er)-17.2(e)-333.7(a)-17.2(to)-17.2(pi)-17.2(c)-334.5(t)-17.2(o)-334.1(g)-17.2(ra)-17.2(ss)]TJ
-1.0015 -1.0641 TD
0 Tc
[(po)15.5(ll)22.2(en)15.1(,)-347.5(b)0(u)21.2(t)-344.6(we)16.9(re)-339.3(st)17.7(ud)15.5(ie)18.4(d)-342.2(o)0(u)15.5(t)-344.6(of)-338.9(se)19.6(as)13.9(on)-337.3(an)20.8(d)-347.9(h)0(a)20.8(d)-347.9(no)-337.3(up)21.2(pe)15.1(r)]TJ
0 -1.0698 TD
[(re)19.2(sp)14.4(ir)17.3(at)18.5(or)19.6(y)-325.1(t)0(r)17.3(a)0(c)14.7(t)-321.8(sy)14.4(mp)18.1(to)18.9(ms)-318.8(or)-316.1(si)17.7(gn)21.2(s)-326.3(o)0(f)-316.1(a)0(c)20.4(u)0(t)18.9(e)-325.5(rh)13.9(in)18.9(it)16.5(is)17.7(.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(e)-575.9(c)0(l)18.5(i)0(n)18.8(i)0(c)18.4(a)0(l)-567.7(a)0(n)20.8(d)-575.5(de)20.8(mo)12.4(gr)19.6(ap)15.1(hi)18.9(c)-570.2(c)0(h)15.1(a)0(r)19.2(a)0(c)14.7(t)0(e)18.4(r)0(i)17.3(s)0(t)17.7(i)0(c)18.4(s)-576.7(of)-560.8(th)13.2(e)]TJ
-1.0015 -1.0698 TD
[(su)20(bj)13.2(ec)20.4(ts)-318.1(st)17.7(ud)21.2(ie)12.8(d)-319.4(a)0(r)13.5(e)-319.8(de)15.1(ta)18.4(il)16.5(ed)-314.9(in)-316.9(ta)18.4(bl)18.9(e)-325.5(1)0(.)]TJ
/F4 1 Tf
25.1977 50.3215 TD
[(Exp)-6.8(eriment)-10.3(al)-334(details)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(Th)17.1(e)-348.3(e)0(x)15.1(p)0(e)20.8(r)0(i)17.3(m)0(e)12(n)0(t)18.9(a)0(l)-334.4(p)0(r)14(o)0(t)18.9(o)0(c)15.1(o)0(l)18.9(s)-343.4(us)14.4(ed)-337.7(we)16.9(re)-339.3(si)17.7(mi)15.7(la)18.5(r)-349.5(t)0(o)-334(t)0(h)13.2(o)0(s)20(e)]TJ
-1.0015 -1.0471 TD
[(pr)13.9(ev)20.8(io)13.2(us)20(ly)-499(re)19.2(po)15.5(rt)17.3(ed)-497([2)13.9(6].)-510(In)-515.3(order)-525.2(to)-521.7(standardiz)-10.7(e)-519(their)]TJ
0 -1.0528 TD
[(recent)-271.5(hist)-9(ory)58.7(,)-262.1(smoking)-268.1(p)-6.5(articipan)-11.1(ts)-261.2(wer)-8.2(e)-262.9(asked)-267.6(to)-265.7(smok)-7.4(e)]TJ
0 -1.0471 TD
[(one)-292.9(cigar)-8.6(ette)-293.2(of)-293.3(their)-295.1(regular)-296.2(brand)-296(10)-286.1(min)-298(prior)-293.9(to)-288.4(bron-)]TJ
0 -1.0528 TD
[(cho)-8.4(scopy)62.9(.)-319.1(4)-313.7(MB)-8.2(q)-313.7(o)0(f)]TJ
7.472 0 0 6.641 394.979 713.31 Tm
0 Tw
(3)Tj
9.963 0 0 9.963 398.721 708.888 Tm
[(H-wat)-10.4(er)-316.5(and)-321.4(1.0)-314.9(MBq)-321.9(of)]TJ
7.472 0 0 6.641 502.186 713.31 Tm
(14)Tj
9.963 0 0 9.963 509.669 708.888 Tm
(C-urea)Tj
-20.1104 -1.0471 TD
[(in)-419.3(0.5)-417.3(mL)-418.5(norm)-7.8(al)-419.7(saline)-421.1(wer)-8.2(e)-416.6(injected)-424.2(intravenous)-11.1(ly)-419.3(5)]TJ
0 -1.0527 TD
[(min)-525.7(before)-520.7(undergoing)-518.5(a)-519(3)]TJ
/F7 1 Tf
11.6087 0 TD
(6)Tj
/F3 1 Tf
1.0015 0 TD
[(60)-519.4(mL)-520.9(sequent)-9.7(ial)-519.6(BAL.)]TJ
-12.6103 -1.0527 TD
[(BAL)-191.5(was)-189.9(performed)-197.7(using)-183.8(ster)-8.6(ile)-189.6(pyrogen)-7.3(-free)-191.5(phospha)-6.9(te-)]TJ
0 -1.0471 TD
[(buffered)-370.2(saline)-375.5(prew)-9(armed)-373.6(to)-368.1(37)]TJ
/F7 1 Tf
13.35 0 TD
(8)Tj
/F3 1 Tf
0.387 0 TD
[(C)-369.7(i)0(n)-373.8(a)-371.1(segment)-377.1(of)-367.3(the)]TJ
-13.737 -1.0528 TD
[(right)-425.6(mid)-7.8(dle)-420.5(lobe)-421.2(using)-422.8(an)-423(Olympu)-8.3(s)-417.4(B)0(F)-420.9(P)0(1)-6.4(0)-416.2(broncho)-7.3(-)]TJ
0 -1.0471 TD
[(scope)-256.2(\(5)-247.8(mm)-246.8(exter)-8.6(nal)-249.8(diameter)-11.1(;)-242.1(O)0(l)-7.8(ympus,)-253.2(T)63.4(okyo,)-248.1(Japan\))-8.2(.)]TJ
0 -1.0527 TD
[(Asp)-7.4(iration)-367.3(of)-367.3(each)-362.8(inje)-8.2(cted)-364.7(aliquot)-365.7(was)-366.3(carri)-10.2(ed)-360.4(out)-363.2(sep-)]TJ
0 -1.0471 TD
[(arate)-9(ly)-356.7(and)-355.5(immedi)-10.3(ately)58.9(,)-353.2(a)0(t)-357.1(a)-354(suction)-364.5(pressure)-359.6(of)-355.9(-6.65\261)]TJ
0 -1.0527 TD
[(-13.3)-312.3(kPa)-303.5(\(-50\2611)-7.8(00)-308.8(mmHg\))-311.5(into)-309.4(individua)-8.7(l)-304.7(glass)-310.6(vessels)]TJ
0 -1.0471 TD
[(kep)-8.4(t)-333.2(o)0(n)-331.6(ice.)]TJ
1.0015 -1.0528 TD
[(Th)17.1(re)13.5(e)-314.2(v)0(e)20.8(n)0(o)15.5(u)0(s)-304.3(b)0(l)18.8(o)0(o)15.5(d)-313.7(sa)19.6(mp)12.4(le)18.4(s)-314.9(\()0(2)19.6(0)-313.7(mL)14(\))-315.3(w)0(e)16.9(r)0(e)-305.1(t)0(a)18.4(k)0(e)15.1(n)-313.8(fr)18(om)]TJ
-1.0015 -1.0471 TD
[(th)13.2(e)-308.5(a)0(r)19.2(m)-311.2(co)20.8(nt)18.9(ra)13.5(la)18.4(te)18.5(ra)13.5(l)-304.7(t)0(o)-299.8(t)0(h)18.8(a)0(t)-300.2(u)0(s)14.4(e)0(d)-297.8(f)0(o)19.6(r)-309.7(th)18.8(e)-308.5(i)0(s)17.7(o)0(t)13.2(o)0(p)21.2(e)-308.5(in)18.8(je)12.8(ct)18.5(io)18.8(n)]TJ
0 -1.0527 TD
[(si)17.7(mu)12.4(lt)16.5(an)20.8(eo)15.1(us)20(ly)-316.9(wi)20.6(th)-316.9(ea)14.7(ch)-314.9(B)11.6(A)0(L)-316.9(a)0(s)13.9(p)0(i)18.9(r)0(a)19.2(t)0(i)16.5(o)0(n)15.5(.)]TJ
1.0015 -1.0471 TD
[(Fo)16.3(ll)16.5(ow)17.3(in)18.9(g)-262.5(m)0(e)17.7(a)0(s)19.6(u)0(r)13.9(e)0(m)17.7(e)0(n)15.1(t)-259.2(of)-247.8(BA)18.3(L)-261(r)0(e)19.2(t)0(u)13.2(r)0(n)-247.8(v)0(o)15.5(l)0(u)18.9(m)0(e)17.7(s)0(,)-252.7(a)-257.2(to)18.9(ta)18.5(l)]TJ
-1.0015 -1.0528 TD
[(ce)14.7(ll)-552.6(co)20.8(un)15.5(t)-555.1(w)0(a)16.9(s)-559.6(pe)15.1(rf)18(or)19.6(me)12(d)-558.4(u)0(s)20(i)0(n)18.8(g)-558.4(a)-558.8(N)0(e)11.2(u)0(b)21.2(a)0(u)15.1(e)0(r)-549.8(c)0(o)20.8(u)0(n)15.5(t)0(i)16.5(n)0(g)]TJ
0 -1.0471 TD
[(ch)15.1(am)17.7(be)15.1(r)-235.7(\()0(R)14.9(e)0(i)18.5(c)0(h)20.8(e)0(r)13.5(t)0(,)-225.5(B)0(u)16.5(f)20.4(fa)13.5(lo)18.8(,)-233.7(N)0(Y)138.6(,)-233.7(US)18.1(A\))15.7(.)-239.4(S)11.4(am)17.7(pl)13.2(es)-225.1(we)16.9(re)-231.2(as)19.6(s-)]TJ
0 -1.0527 TD
[(es)13.9(se)19.6(d)-296.7(f)0(o)19.6(r)-292.6(ob)15.5(vi)18.9(ou)15.5(s)-292.2(b)0(l)18.9(e)0(e)14.7(d)0(i)18.9(n)0(g)-286.1(a)0(t)-288.8(t)13.9(hi)13.2(s)-292.2(s)0(t)17.7(a)0(g)15.1(e)-291.4(wi)14.9(th)-282.7(th)13.2(e)-291.4(i)0(n)18.9(t)0(e)12.8(n)0(t)18.9(i)0(o)18.8(n)]TJ
0 -1.0471 TD
[(of)-208(ex)20.8(cl)12.8(ud)21.2(in)18.9(g)-217(a)0(n)20.8(y)-211.3(su)14.4(ch)-201.1(sa)13.9(mp)18.1(le)18.5(s)-212.5(f)0(r)12.4(o)0(m)-203.8(f)0(u)19.6(r)0(t)17.3(h)0(e)15.1(r)-212.9(an)15.1(al)18.5(ys)20(is)17.7(.)-210.9(I)0(n)-208(t)0(h)18.9(e)]TJ
0 -1.0528 TD
[(ev)15.1(en)15.1(t)13.9(,)-313.4(th)13.2(i)13.9(s)-314.9(wa)16.9(s)-314.9(n)0(o)21.2(t)-316.1(re)19.2(qu)15.5(ir)17.3(ed)-303.5(fo)19.6(r)-315.3(a)0(n)15.1(y)-313.7(of)-304.7(th)18.9(e)-314.1(s)0(a)19.6(m)0(p)18.1(l)0(e)12.8(s)0(.)-298.2(C)0(e)16.1(l)0(l)16.5(s)]TJ
0 -1.0471 TD
[(we)16.9(re)-219.8(se)19.6(pa)15.1(ra)19.2(te)18.4(d)-228.4(f)0(r)18(o)0(m)-215.2(t)0(h)18.9(e)-223.1(BA)12.6(L)-221.1(s)0(u)14.3(p)0(e)20.8(r)0(n)13.9(a)0(t)18.5(a)0(n)20.8(t)0(,)-219.8(a)0(n)20.8(d)-222.7(pl)13.2(as)19.6(ma)-215.6(wa)16.9(s)]TJ
0 -1.0527 TD
[(se)13.9(pa)20.8(ra)13.5(te)18.4(d)-222.7(f)0(r)12.4(o)0(m)-215.2(w)0(h)17.3(o)0(l)18.9(e)-228.8(bl)18.9(oo)15.5(d)-222.7(w)0(i)14.9(t)0(h)18.9(i)0(n)-220.2(1)-222.7(h)-228.4(b)0(y)-217.8(c)0(e)20.4(n)0(t)18.9(r)0(i)17.3(f)0(u)14(g)0(a)20.8(t)0(i)16.5(o)0(n)-217.8(a)0(t)]TJ
0 -1.0471 TD
(4)Tj
/F7 1 Tf
0.4951 0 TD
(8)Tj
/F3 1 Tf
0.3756 0 TD
0.4157 Tc
[(C\()415.7(2)435.3(0)-0.5(m)415.7(i)431.4(na)415.7(t)13(1)415.7(0)431.2(0)]TJ
/F7 1 Tf
7.3237 0 TD
0 Tc
(6)Tj
/F4 1 Tf
0.9902 0 TD
(g)Tj
/F3 1 Tf
0.9162 0 TD
[(an)15.1(d)-410.5(1)0(0)-405.6(m)0(i)15.7(n)-416.2(at)-408.3(20)21.2(0)]TJ
/F7 1 Tf
7.7676 0 TD
(6)Tj
/F4 1 Tf
0.9902 0 TD
(g)Tj
/F3 1 Tf
0.4894 0 TD
0.4158 Tc
[(,r)415.8(e)435(s)415.8(p)430.2(e)415.8(c)436.2(-)]TJ
-19.3479 -1.0528 TD
0 Tc
[(ti)16.5(ve)15.1(ly)18.8(\).)-429.5(B)11.6(A)0(L)-430.7(s)0(u)20(p)0(e)15.1(r)0(n)19.6(a)0(t)18.5(a)0(n)15.1(t)0(s)-426.2(a)0(n)15.1(d)-433.3(ma)17.7(tc)18.4(he)15.1(d)-433.3(p)0(l)13.2(a)0(s)19.6(m)0(a)-426.2(s)0(a)14(m)0(p)18.1(l)0(e)18.4(s)]TJ
0 -1.0471 TD
[(we)16.9(re)-282.4(su)14.4(bd)21.2(iv)18.9(id)13.2(ed)-280.8(in)18.9(to)-277.1(1.)15.9(8-)19.6(mL)-281.9(al)12.8(i)13.9(q)0(u)15.5(o)0(t)18.9(s)-292.2(an)20.8(d)-291(s)0(t)17.7(o)0(r)19.6(e)0(d)-280.8(a)0(t)-283.1(-)0(8)19.6(0)]TJ
/F7 1 Tf
21.7607 0 TD
(8)Tj
/F3 1 Tf
0.3756 0 TD
(C)Tj
-22.1362 -1.0528 TD
[(un)15.5(ti)16.5(l)-321.8(s)0(u)14.4(b)0(s)20(e)0(q)15.1(u)0(e)20.8(n)0(t)-316.9(a)0(s)19.6(s)0(a)13.9(y)73.2(.)]TJ
/F4 1 Tf
0 -3.972 TD
[(Isot)-8.2(ope)-332.8(meas)-8.6(ur)31.4(emen)-7.8(t)]TJ
/F3 1 Tf
1.0015 -2.2478 TD
[(In)-634.8(pr)13.9(ev)20.8(io)18.9(us)-634.4(wo)17.3(rk)13.9(,)-637.7(i)0(t)-632.3(w)0(a)11.2(s)-639.3(sh)20(ow)17.3(n)-643.8(t)0(h)18.9(a)0(t)12.8(,)-637.7(in)-635.6(se)19.6(pa)15.1(ra)19.2(te)]TJ
-1.0015 -1.0528 TD
[(me)12(as)19.6(ur)19.6(em)12(en)20.8(ts)-688(of)-680.3(th)13.2(re)19.2(e)-695.4(p)0(l)18.9(a)0(s)19.6(m)0(a)-687.9(s)0(a)19.6(m)0(p)18.1(l)0(e)12.8(s)0(,)-679.5(t)0(h)13.2(e)-689.7(di)18.9(lu)13.2(ti)22.2(on)]TJ
0 -1.0471 TD
[(vo)15.5(lu)18.9(me)17.7(s)-326.3(f)0(o)19.6(r)]TJ
7.472 0 0 6.641 360 368.901 Tm
(3)Tj
9.963 0 0 9.963 363.628 364.479 Tm
[(H)-323.4(i)0(n)-316.9(a)0(l)18.5(l)-327.5(su)20(bj)18.9(ec)14.7(ts)-312.4(we)16.9(re)-316.5(eq)15.1(ua)20.8(l)-327.5(t)0(o)-311.2(o)0(r)-316.1(e)0(x)15.1(c)0(e)20.4(e)0(d)15.1(e)0(d)]TJ
-5.4515 -1.0527 TD
[(es)13.9(ti)16.5(ma)17.7(te)18.4(s)-366.1(o)0(f)-361.6(t)0(o)18.9(t)0(a)18.4(l)-367.3(bo)15.5(dy)-360(w)12.4(a)0(t)12.8(e)0(r)-356.3(b)0(a)15.1(s)0(e)19.6(d)-370.7(on)-354.3(ca)14.7(lc)18.4(ul)18.8(at)18.5(ed)-360.4(va)15.1(lu)18.9(es)]TJ
0 -1.0471 TD
[(ac)14.7(co)15.1(rd)19.6(in)18.9(g)-558.4(t)0(o)-550.2(t)0(h)13.2(e)-558.8(su)20(bj)18.9(ec)14.7(t)]TJ
/F7 1 Tf
10.2032 0 TD
(')Tj
/F3 1 Tf
0.2106 0 TD
[(s)-559.6(h)0(e)20.8(i)0(g)18.8(h)0(t)-555.9(a)0(n)20.8(d)-558.4(we)16.9(ig)13.2(ht)-550.2([2)19.6(6].)-561.2(In)]TJ
-10.4137 -1.0527 TD
[(add)-8.4(ition,)-483.7(dilu)-7.8(tion)-485.8(volumes)-490.5(calculated)-489.1(from)]TJ
7.472 0 0 6.641 491.641 337.493 Tm
(14)Tj
9.963 0 0 9.963 499.124 333.071 Tm
[(C)-483.5(counts)]TJ
-19.052 -1.0471 TD
[(wer)-8.2(e)-581.6(i)0(n)-578.7(excess)-588.6(of)-577.9(the)-585.5(volume)-585.3(of)-577.9(extra)-8.6(cellular)-590.8(fluid,)]TJ
0 -1.0527 TD
[(indi)-7.8(cating)-454(that)-457.8(the)-454.6(isotopes)-457.5(had)-452.3(equilibra)-10.7(ted)-454.6(with)-455.6(their)]TJ
0 -1.0471 TD
[(target)-375.9(compa)-7.8(rtments)-10.7(.)-370.3(Bac)-7.8(kground)-6.9(-corr)-9(ected)]TJ
7.472 0 0 6.641 489.6 306.142 Tm
(14)Tj
9.963 0 0 9.963 497.083 301.72 Tm
[(C)-381.1(and)]TJ
7.472 0 0 6.641 525.6 306.142 Tm
(3)Tj
9.963 0 0 9.963 529.285 301.72 Tm
(H)Tj
-22.0793 -1.0527 TD
[(cou)-8.4(nts)-500.9(were)-504.5(obtai)-9(ned)-503.5(from)-504.5(BAL)-510.1(and)-503.5(plasma)-507.2(samples)]TJ
0 -1.0471 TD
[(using)-525.2(a)-519(liqu)-7.8(id)-516.1(scint)-10.2(illation)-524.9(counte)-7.8(r)-520.2(\(Packard)-527.6(T)29.3(r)0(i)-523.3(Carb)]TJ
0 -1.0528 TD
[(220)-8(0;)-334(Packard)-343.1(Meriden,)-342.5(CA,)-334.9(USA)-9.4(\).)-332.8(A)-334.8(count)-342.3(time)-335.7(of)-338.9(60)]TJ
ET
1 i 
58.28 244.573 478.205 -0.51 re
f
58.28 228.132 478.205 -0.51 re
f
58.28 126.482 478.205 -0.51 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 248.882 Tm
[(Table)-331.9(1.)-336.7(\261)-333.2(Clinical)-334(and)-335.7(demograhic)-330(characteristics)-336.3(of)-336.7(the)-328.5(subjects)-334.6(studied*)]TJ
/F3 1 Tf
0 -1.7072 TD
[(Subject)-334.4(No.)-3849.5(Smoking)-334.4(status)-3532.1(Smoking)-334.4(exposure)-332.7(pack-yrs)-3533.1(Age)-336.7(yrs)-3528.8(FEV)]TJ
7.173 0 0 7.173 432.227 233.575 Tm
(1)Tj
8.966 0 0 8.966 438.803 233.575 Tm
[(%)-328.8(pred)-4355.2(Atopy)]TJ
-42.4394 -1.998 TD
[(1)-9660.9(Smoker)]TJ
/F8 1 Tf
23.1735 0 TD
(>)Tj
/F3 1 Tf
0.5501 0 TD
[(10)-9477(32)-6669.7(1)32.1(1)0(0)-5544.2(Nonatopic)]TJ
-23.7236 -1.0559 TD
[(2)-9660.9(Smoker)-10481.5(68)-9477(42)-6638.1(106)-5543.7(Nonatopic)]TJ
T*
[(3)-9660.9(Smoker)-10981(6)-9477.6(3)0(0)-6638.1(102)-5543.7(Nonatopic)]TJ
T*
[(4)-9660.9(Smoker)-10481.5(82)-9477(53)-6669.7(1)32.1(1)0(8)-5544.2(Nonatopic)]TJ
T*
[(5)-9660.9(Smoker)-10481.5(14)-9477(28)-6669.7(1)32.1(1)0(4)-6265(Atopic)]TJ
T*
[(6)-8889.5(Nonsmoker)-10201.4(0)-9477.6(2)0(7)-6638.1(101)-5543.7(Nonatopic)]TJ
T*
[(7)-8889.5(Nonsmoker)-10201.4(0)-9477.6(2)0(1)-6638.1(109)-5543.7(Nonatopic)]TJ
T*
[(8)-8889.5(Nonsmoker)-10201.4(0)-9477.6(2)0(0)-6669.7(1)32.1(13)-5544.2(Nonatopic)]TJ
T*
[(9)-8889.5(Nonsmoker)-10201.4(0)-9477.6(2)0(0)-7137.6(9)0(6)-6265(Atopic)]TJ
T*
[(10)-8389.5(Nonsmoker)-10201.4(0)-9477.6(3)0(7)-6638.1(106)-6264.5(Atopic)]TJ
0 -1.9411 TD
[(*:)-336.5(all)-331.8(male.)-333.5(FEV)]TJ
7.173 0 0 7.173 119.168 113.046 Tm
(1)Tj
8.966 0 0 8.966 122.74 113.046 Tm
[(:)-337(forced)-333.5(expiratory)-336.3(volume)-336.1(in)-330.2(one)-333.4(second.)]TJ
-7.1891 76.3365 TD
(286)Tj
7.472 0 0 7.472 269.121 797.499 Tm
0.0001 Tc
[(C.)-335.8(W)102.5(ARD)-333.4(ET)-263.8(AL.)]TJ
ET
endstream
endobj
17 0 obj
<<
/ProcSet [/PDF /Text ]
/Font <<
/F2 5 0 R
/F3 6 0 R
/F4 7 0 R
/F6 9 0 R
/F7 10 0 R
/F8 11 0 R
>>
/ExtGState <<
/GS2 13 0 R
>>
>>
endobj
19 0 obj
<<
/Length 24545
>>
stream
BT
/F3 1 Tf
9.963 0 0 9.963 58.28 771.647 Tm
0 g
/GS2 gs
0 Tc
[(min)-491.5(per)-493.7(sample)-490.1(and)-492.1(an)-491.3(appropr)-8.9(iate)-492.3(quench)-489.1(correct)-12.1(ion)]TJ
0 -1.0471 TD
[(curve)-228.2(were)-225.6(used)-226.6(to)-225.8(expres)-8.2(s)-218.2(resul)-9.4(ts)-221.3(in)-225.8(mean)-223.2(disi)-9(ntegratio)-10.7(ns)]TJ
0 -1.0528 TD
[(per)-334.3(min)-7.8(ute)-335.1(\(dpm)-7.8(\).)]TJ
/F4 1 Tf
0 -3.107 TD
[(Calcul)-8.8(ations)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(Th)17.1(e)-262.9(a)0(m)12(o)0(u)21.2(n)0(t)-254.3(o)0(f)-259.2(B)11.6(AL)-260(fl)17.3(ui)18.9(d)-262.5(u)0(r)13.9(e)0(a)-252.7(o)0(r)-259.2(w)0(a)16.9(t)0(e)18.4(r)-264.1(de)15.1(ri)17.3(ve)20.8(d)-268.2(a)0(c)20.4(u)0(t)18.9(e)0(l)12.8(y)]TJ
-1.0015 -1.0527 TD
[(by)-360(in)18.9(fl)17.3(ux)-360(fr)18(om)-363.2(th)18.9(e)-371.1(c)0(i)18.4(r)0(c)19.2(u)0(l)13.2(a)0(t)18.5(i)0(o)18.9(n)-370.7(w)12.4(a)0(s)-361.6(c)0(a)14.7(l)0(c)18.4(u)0(l)18.9(a)0(t)18.4(e)0(d)-360.4(b)0(y)-360(p)0(r)13.9(o)0(p)21.2(o)0(r)25.3(-)]TJ
0 -1.0471 TD
[(ti)16.5(on)21.2(al)12.8(it)16.5(y:)]TJ
ET
1 i 
91.729 658.375 91.956 -0.397 re
f*
BT
/F10 1 Tf
9.963 0 0 9.963 91.729 662.456 Tm
-0.0118 Tc
[(dp)-11.8(m)]TJ
1.8893 0.1992 TD
0 Tc
0 Tw
(.)Tj
0.2675 -0.1992 TD
[(mL)-331.6(B)13(A)0(L)-326.7(f)0(l)16.9(u)0(i)14.3(d)]TJ
/F11 1 Tf
6.974 0 0 6.974 174.274 666.085 Tm
(\377)Tj
/F10 1 Tf
0.7723 0 TD
(1)Tj
9.963 0 0 9.963 98.419 648.85 Tm
-0.0118 Tc
[(dp)-11.8(m)]TJ
1.8893 0.1992 TD
0 Tc
(.)Tj
0.2731 -0.1992 TD
[(mL)-325.9(pl)20(as)14.4(ma)]TJ
/F11 1 Tf
6.974 0 0 6.974 167.584 651.742 Tm
(\377)Tj
/F10 1 Tf
0.7723 0 TD
(1)Tj
/F12 1 Tf
9.963 0 0 9.963 185.329 655.71 Tm
(|)Tj
/F11 1 Tf
1.0015 0 TD
(\211)Tj
/F10 1 Tf
0.2731 0 TD
[(p)11.8(l)0(a)13.2(s)0(m)17.7(a)-330.8(ur)15.5(ea)]TJ
/F11 1 Tf
5.1443 0 TD
2.0859 Tc
(\212\205)Tj
/F13 1 Tf
2.7428 0 TD
0 Tc
(1)Tj
/F11 1 Tf
0.5008 0 TD
(\206)Tj
/F3 1 Tf
-21.4135 -3.1981 TD
[(Wh)14.4(er)19.2(e)-410.9([)0(U)15.7(])-412.1(is)-403.4(t)13.9(h)0(e)-406(c)0(o)20.8(n)0(c)15.1(e)0(n)20.8(t)0(r)17.3(a)0(t)12.8(i)0(o)18.9(n)-410.5(of)-401.5(ur)19.6(ea)-406.4(in)-402.3(B)11.6(A)0(L)-402.2(f)0(l)17.3(u)0(i)13.2(d)]TJ
-1.0015 -1.0471 TD
[(de)15.1(ri)17.3(ve)20.8(d)-262.5(f)0(r)18(o)0(m)-249.4(t)0(h)18.9(e)-262.9(ci)18.5(rc)19.2(ul)13.2(at)18.5(io)18.9(n,)-251.5(an)20.8(d)-262.5(t)13.9(he)-252.3(dp)15.5(m)-260(c)0(o)20.8(r)0(r)12.4(e)0(s)19.6(p)0(o)21.2(n)0(d)15.5(e)0(d)-252.3(t)0(o)]TJ
7.472 0 0 6.641 58.28 607.351 Tm
(14)Tj
9.963 0 0 9.963 65.537 602.929 Tm
[(C-)14.9(la)18.4(be)15.1(ll)16.5(ed)-314.9(ur)19.6(ea)14.7(.)]TJ
/F4 1 Tf
-0.7284 -3.107 TD
[(T)79.7(otal)-337.9(ur)31.4(ea)-332(a)-6.5(ssays)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(Th)17.1(e)-314.2(s)0(u)14.4(p)0(e)20.8(r)0(n)13.9(a)0(t)18.4(a)0(n)20.8(t)0(s)-306.7(f)0(r)12.4(o)0(m)-306.3(t)0(h)18.9(e)-314.2(th)13.2(re)19.2(e)-314.2(s)0(e)13.9(p)0(a)20.8(r)0(a)13.5(t)0(e)-305.9(B)11.6(AL)-311.2(al)18.4(iq)18.9(uo)15.5(ts)]TJ
-1.0015 -1.0527 TD
[(we)16.9(re)-481.5(an)20.8(al)18.5(ys)14.4(ed)-474.2(in)-481.9(du)21.2(pl)13.2(i)13.9(c)0(a)14.7(t)0(e)-476.6(f)0(o)13.9(r)-486.1(to)18.9(ta)18.4(l)-486.8(u)0(r)13.9(e)0(a)-474.7(c)0(o)15.1(n)0(c)15.1(e)0(n)20.8(t)0(r)17.3(a)0(t)18.4(i)0(o)13.2(n)]TJ
0 -1.0471 TD
[(us)20(in)13.2(g)-308.1(a)-308.5(co)15.1(mm)14.9(er)19.2(ci)18.4(al)-300.2(ur)14(ea)20.4(se)13.9(/)13.9(u)0(l)13.2(t)0(r)17.3(a)0(v)20.8(i)0(o)18.9(l)0(e)12.8(n)0(t)-299.8(\()0(3)19.6(4)0(0)-303.1(n)0(m)18.1(\))-309.6(ki)18.9(t)-310.4(\()0(S)14.7(i)0(g)18.9(-)]TJ
0 -1.0528 TD
-0.0186 Tc
[(m)-18.6(a)-0.9(,)-400.3(S)-7.2(t)-397.3(L)-18.6(ou)-18.6(i)-5.4(s)-18.6(,)-385.1(M)-18.6(O,)-400.3(U)-6.2(S)-18.6(A)-6.2(\))-18.6(.)-385.5(P)-18.6(l)-4.6(a)-18.6(sm)-18.6(a)-393.6(l)-18.6(ev)-18.6(el)-18.6(s)-393.6(w)-6.2(e)-18.6(r)-5.1(e)-395.3(m)-18.6(e)-6.6(a)-18.6(su)-18.6(re)-18.6(d)]TJ
0 -1.0471 TD
0 Tc
[(us)20(in)13.2(g)-359.3(a)-359.7(CO)12.6(B)11.6(A)0(S)12.4(-)0(F)94.4(A)0(R)12.6(A)-357.5(II)-357.5(au)20.8(to)18.9(an)15.1(al)18.4(ys)14.4(er)-350.7(\(R)14.9(oc)20.8(he)-354.7(Di)14.9(ag)20.8(no)15.5(s-)]TJ
0 -1.0527 TD
[(ti)16.5(cs)19.6(,)-256.5(B)11.6(as)13.9(le)18.4(,)-250.8(S)0(w)12.4(i)0(t)22.2(z)0(e)14.7(r)0(l)17.3(a)0(n)15.1(d)0(\))19.6(.)-250.8(Al)14.9(l)-253.5(a)0(s)13.9(s)0(a)19.6(y)0(s)-247.4(w)12.4(er)13.5(e)-251.6(p)0(e)15.1(r)0(f)18(o)0(r)19.6(m)0(e)12(d)-251.2(in)-242.9(th)13.2(e)]TJ
0 -1.0471 TD
[(De)16.9(pt)-265.7(of)-264.9(Cl)14.1(i)13.9(n)0(i)13.2(c)0(a)20.4(l)-276.3(B)11.6(i)0(o)13.2(c)0(h)20.8(e)0(m)17.7(i)0(s)12(t)13.9(ry)-264.9(at)-266.1(Mo)13.6(na)20.8(sh)-264.5(Me)13.2(di)18.9(ca)14.7(l)-270.6(C)0(e)16.1(n)0(t)18.9(r)0(e)13.5(,)]TJ
0 -1.0528 TD
[(Cl)14.1(ay)20.8(to)18.9(n,)-314.1(V)57.9(i)0(c)18.4(t)0(o)18.9(r)0(i)17.3(a)-325.5(by)-314.5(on)15.5(e)-325.5(o)0(f)-316.1(t)0(h)18.9(e)-325.5(au)20.8(th)18.9(or)13.9(s)-320.6(\()0(J)12.8(.)-319.1(Se)15.9(co)15.1(mb)18.1(e\))19.2(.)]TJ
/F4 1 Tf
0 -3.107 TD
[(Statist)-10.4(ical)-338.3(analysis)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(Th)17.1(e)-769.4(g)0(e)15.1(n)0(e)20.8(r)0(a)13.5(l)0(i)16.5(z)0(e)20.4(d)-769(li)16.5(ne)15.1(ar)-760.4(mo)18.1(de)15.1(l)-771.4(t)0(e)18.4(s)0(t)-761.9(w)0(a)16.9(s)-770.2(us)14.4(ed)-758.8(fo)13.9(r)]TJ
-1.0015 -1.0527 TD
[(co)15.1(mp)18.1(ar)19.2(is)17.7(on)-434(of)-435.6(da)15.1(ta)-436.8(us)20(in)18.9(g)-444.6(M)0(i)16.9(n)0(i)18.9(t)0(a)18.5(b)-444.6(so)14.3(ft)17.3(wa)16.9(re)-436(\(r)18(el)18.4(ea)14.7(se)-435.6(1)44.8(1)0(,)]TJ
0 -1.0471 TD
[(Mi)16.9(ni)18.9(ta)12.8(b,)-280(Co)16.5(ve)15.1(nt)18.9(ry)82.2(,)-296.3(U)12.4(K\))15.7(.)-296.3(A)-289.2(p-)13.9(va)20.8(lu)13.2(e)]TJ
/F8 1 Tf
14.215 0 TD
(<)Tj
/F3 1 Tf
0.5406 0 TD
[(0.)15.9(05)-286.1(w)12.4(a)0(s)-287.7(c)0(o)20.8(n)0(s)14.4(i)0(d)18.9(e)0(r)19.2(e)0(d)]TJ
-14.7556 -1.0527 TD
[(si)17.7(gn)15.5(if)17.3(ic)18.4(an)20.8(t.)]TJ
/F6 1 Tf
9.8617 -3.107 TD
(Results)Tj
/F3 1 Tf
-8.8602 -2.0998 TD
-0.018 Tc
[(T)-18(h)-0.9(e)-457.3(o)-18(bs)-18(er)-18(ve)-18(d)-452.4(m)-18(ea)-18(n)-446.7(p)-18(l)-4.8(a)-18(sm)-18(a)-449.9(u)-18(re)-18(a)-452.8(l)-18(ev)-18(el)-4.1(s)-458.1(w)-18(er)-18(e)-454(6)-18(.3)-18(\2131)-18(.0)]TJ
/F8 1 Tf
-1.0015 -1.0471 TD
0 Tc
(m)Tj
/F3 1 Tf
0.5634 0 TD
[(mo)18.1(l)]TJ
/F9 1 Tf
1.5137 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 95.244 336.642 Tm
-0.0185 Tc
(-1)Tj
9.963 0 0 9.963 104.598 332.22 Tm
0 Tc
[(in)-322.6(th)18.9(e)-336.9(n)0(o)21.2(n)0(s)14.4(m)0(o)18.1(k)0(e)20.8(r)0(s)-328.7(a)0(n)20.8(d)-336.5(5.)21.6(3\213)16.7(1.)15.9(6)]TJ
/F8 1 Tf
12.7411 0 TD
(m)Tj
/F3 1 Tf
0.5634 0 TD
[(mo)18.1(l)]TJ
/F9 1 Tf
1.5137 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 268.498 336.642 Tm
-0.0185 Tc
(-1)Tj
9.963 0 0 9.963 277.852 332.22 Tm
0 Tc
(in)Tj
-22.0395 -1.0528 TD
[(th)18.9(e)-308.5(s)0(m)16.9(o)0(k)15.5(e)0(r)19.2(s)-309.2(\()]TJ
6.974 0 0 6.974 111.742 321.732 Tm
0.0001 Tc
(NS)Tj
9.963 0 0 9.963 120.472 321.732 Tm
0.3077 Tc
(,p)Tj
/F8 1 Tf
1.0471 0 TD
0 Tc
(=)Tj
/F3 1 Tf
0.5406 0 TD
[(0.)15.9(3\))19.6(.)-307.7(B)0(A)12.6(L)-306.5(fl)17.3(ui)18.9(d)-308.1(t)0(o)18.9(t)0(a)18.4(l)-310.4(ce)20.4(ll)-302.2(co)20.8(un)15.5(ts)-295.3(fr)12.4(om)]TJ
-7.8302 -1.0471 TD
[(sm)16.9(ok)15.5(er)19.2(s)-576.7(w)0(e)16.9(r)0(e)-566.9(e)0(l)12.8(e)0(v)20.8(a)0(t)18.4(e)0(d)15.1(:)-577.9(al)18.5(iq)18.9(uo)15.5(t)-577.9(2)0(,)-564.5(m)0(e)17.7(d)0(i)13.2(a)0(n)-565.3(2)0(7)15.5(0)]TJ
/F7 1 Tf
20.4518 0 TD
(6)Tj
/F3 1 Tf
0.9902 0 TD
(10)Tj
7.472 0 0 6.641 281.707 315.723 Tm
(3)Tj
9.963 0 0 9.963 58.28 300.813 Tm
[(\(r)18(an)15.1(ge)-292.2(10)15.5(0\261)21.2(63)15.5(0\))]TJ
/F4 1 Tf
6.84 0 TD
[(ve)14.7(rs)18.9(us)]TJ
/F3 1 Tf
2.7884 0 TD
(90)Tj
/F7 1 Tf
0.9845 0 TD
(6)Tj
/F3 1 Tf
0.9902 0 TD
(10)Tj
7.472 0 0 6.641 183.685 305.235 Tm
(3)Tj
9.963 0 0 9.963 190.431 300.813 Tm
[(ce)20.4(ll)16.5(s)]TJ
/F9 1 Tf
1.7527 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 224.107 305.235 Tm
(-1)Tj
9.963 0 0 9.963 233.178 300.813 Tm
[(\(4)13.9(5\261)21.2(13)15.5(0\))-293.3(\(p)]TJ
/F8 1 Tf
4.689 0 TD
(<)Tj
/F3 1 Tf
-22.2444 -1.0471 TD
[(0.)15.9(05)21.2(\);)-386.8(al)18.4(iq)18.9(uo)15.5(t)-390.1(3)0(,)15.9(3)0(0)21.2(0)-393.4(\(8)13.9(0\261)21.2(69)15.5(0\))]TJ
/F4 1 Tf
12.3599 0 TD
[(ve)20.4(rs)18.9(us)]TJ
/F3 1 Tf
2.8737 0 TD
[(70)-388.5(ce)20.4(ll)16.5(s)]TJ
/F9 1 Tf
3.1412 0.1992 TD
(.)Tj
/F3 1 Tf
0.2731 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 257.556 294.803 Tm
(-1)Tj
9.963 0 0 9.963 267.534 290.381 Tm
[(\(3)19.6(0\261)]TJ
-21.0038 -1.0528 TD
[(12)15.5(0\))-236.4(\(p)]TJ
/F8 1 Tf
2.8453 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(05)15.5(\).)-236.1(BA)18.3(L)-249.6(r)0(e)19.2(t)0(u)18.9(r)0(n)-242.1(v)0(o)21.2(l)0(u)18.9(m)0(e)12(s)-246.7(w)12.4(e)0(r)13.5(e)-245.9(si)17.7(mi)15.7(la)18.4(r)-247.1(\()0(t)17.3(a)0(b)20.8(l)0(e)-243.3(2\).)]TJ
-3.3916 -1.0471 TD
[(T)63.4(able)-336.3(2)-336.5(includes)-342.9(the)-335.1(individua)-8.7(l)-333.2(radio)-8.2(isotope)-336.1(acti)-8.6(vities)-337.7(in)]TJ
0 -1.0527 TD
[(the)-323.7(BAL)-322.3(fluid)-328.8(and)-321.4(plasma)-325.1(toget)-9(her)-323(with)-324.7(the)-323.7(backgro)-7.7(und)]TJ
0 -1.0471 TD
[(levels)-381.2(observ)-7.8(ed.)-372.2(The)-376.7(coefficient)-373.1(of)-378.7(variation)-380.6(for)-375.4(plasm)-10.9(a)]TJ
0 -1.0528 TD
[(counts)-173.6(was)]TJ
/F14 1 Tf
4.4728 0 TD
(#)Tj
/F3 1 Tf
0.8365 0 TD
[(0.02)-162(an)-7.6(d)-160.1(for)-170.5(BAL)-168.7(supern)-7.8(atant)-168.7(samp)-7.8(les)]TJ
/F14 1 Tf
15.08 0 TD
(#)Tj
/F3 1 Tf
0.8365 0 TD
(4%.)Tj
-21.2257 -1.0527 TD
[(The)-399.5(calcul)-10.6(ated)-398.9(radio)-8.2(labelled)-401.4(urea)-403.8(and)-401(water)-399.5(flux)-405.4(in)-396.6(the)]TJ
0 -1.0471 TD
[(different)-307.4(aliquots)-310.7(are)-312(summari)-11.5(zed)-304.7(in)-311.2(figure)-312.2(1)-302.4(and)-310(table)-311(2)]TJ
0 -1.0527 TD
[(respec)-8.6(tively)56.2(.)]TJ
1.0015 -1.0471 TD
[(Ov)17.3(er)13.5(al)18.5(l,)-293.7(in)-294.1(al)12.8(l)-304.7(s)0(u)20(b)0(j)18.9(e)0(c)14.7(t)0(s)17.7(,)-302(th)18.9(er)13.5(e)-302.8(w)0(a)16.9(s)-309.2(a)-302.8(s)0(i)17.7(g)0(n)15.5(i)13.9(fi)11.6(ca)20.4(nt)-294.1(in)13.2(cr)19.2(ea)14.7(se)]TJ
-1.0015 -1.0527 TD
[(in)-624.2(ur)19.6(ea)-628.3(le)18.4(ve)20.8(ls)-625.4(in)-624.2(se)19.6(qu)15.5(en)15.1(t)13.9(i)0(a)12.8(l)-629.1(al)12.8(i)13.9(q)0(u)15.5(o)0(t)18.9(s)0(,)-622.6(u)0(s)14.4(i)0(n)18.9(g)-632.4(bo)21.2(th)-624.2(th)13.2(e)]TJ
0 -1.0471 TD
[(ra)19.2(di)13.2(ot)18.9(ra)19.2(ce)14.7(r)-486.1(m)13.2(et)12.8(ho)21.2(d)-484.5(a)0(n)15.1(d)-484.5(th)18.9(e)-484.9(b)0(i)18.9(o)0(c)15.1(h)0(e)20.8(m)0(i)15.7(c)0(a)14.7(l)-481.2(as)13.9(sa)19.6(y)-484.5(\()0(p)]TJ
/F8 1 Tf
20.2697 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(05)15.5(;)]TJ
-20.816 -1.0528 TD
[(fi)17.3(gs)20(.)-393(1)-393.4(and)-406.7(2\).)-401.8(This)-409.1(was)-406.2(so)-401.1(for)-409.5(both)-403.8(smok)-7.4(ers)-403.8(and)-406.7(non-)]TJ
0 -1.0471 TD
[(smok)-7.4(ers.)-358.7(This)-357.9(means)-367.5(that,)-355.7(inevi)-9(tably)59.3(,)-358.9(there)-361.4(was)-360.6(a)-354(signi)-9.8(-)]TJ
0 -1.0528 TD
[(fican)-8.6(t)-373(incre)-8.6(ase)-379.9(in)-379.5(the)-380.7(calculated)-386.7(volum)-9.3(es)-378.7(of)-378.7(ELF)-379.6(in)-379.5(the)]TJ
0 -1.0471 TD
[(sequent)-9.7(ial)-337.5(aliquots)-339.2(\(p)]TJ
/F8 1 Tf
8.6496 0 TD
(<)Tj
/F3 1 Tf
0.552 0 TD
[(0.05\);)-338.2(tabl)-8.2(e)-331.2(2)0(.)]TJ
-8.2001 -1.0528 TD
[(Th)17.1(er)19.2(e)-553.2(w)12.4(er)13.5(e)-547.5(l)0(o)18.9(w)0(e)16.9(r)-548.7(le)12.8(ve)20.8(ls)-540(of)-543.7(B)11.6(A)0(L)-544.5(f)0(l)17.3(u)0(i)18.9(d)-547.1(ur)14(ea)-537.2(in)-538.8(th)13.2(e)]TJ
-1.0015 -1.0471 TD
[(sm)16.9(ok)15.5(er)19.2(s)-286.5(c)0(o)20.8(m)0(p)18.1(a)0(r)13.5(e)0(d)-275.1(t)0(o)-277.1(t)13.9(he)-275.1(no)15.5(ns)20(mo)12.4(ke)20.8(rs)-277.5(in)-277.1(al)18.4(l)-282(a)0(l)18.4(i)0(q)13.2(u)0(o)21.2(t)0(s)17.7(.)-284.9(Th)17.1(is)]TJ
25.1977 66.1583 TD
[(wa)16.9(s)-451.5(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(t)-447(us)20(in)18.9(g)-450.3(t)0(h)18.9(e)-445(ra)19.2(di)13.2(ot)18.9(ra)19.2(ce)14.7(r)-446.2(m)0(e)17.7(t)0(h)18.8(o)0(d)-439.7(\()0(p)]TJ
/F8 1 Tf
19.4901 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(00)15.5(5\))19.6(.)]TJ
-20.0364 -1.0471 TD
[(Th)17.1(er)13.5(e)-439.3(w)0(a)16.9(s)-445.8(no)-434(su)20(gg)21.2(es)13.9(ti)16.5(on)-434(t)13.9(h)0(a)15.1(t)-441.3(th)18.9(e)-445(g)0(r)19.6(a)0(s)13.9(s)-440.1(po)15.5(ll)16.5(en)20.8(-s)18.4(en)15.1(si)17.7(ti)16.5(ve)]TJ
0 -1.0528 TD
[(at)12.8(op)21.2(ic)-260.4(in)13.2(di)18.9(vi)18.9(du)15.5(al)18.5(s)-269.4(w)0(e)16.9(r)0(e)-259.6(d)0(i)18.9(f)14.7(fe)19.2(re)19.2(nt)-265.7(w)12.4(i)0(t)16.5(h)-268.2(re)13.5(ga)20.8(rd)-264.9(to)-260(B)11.6(A)0(L)-265.7(f)0(l)17.3(u)0(i)18.8(d)]TJ
0 -1.0471 TD
[(ur)13.9(ea)-315.3(le)18.4(ve)15.1(ls)-312.4(\(f)18(ig)13.2(s.)-309.6(1)-325.1(and)-338.4(2\).)]TJ
1.0015 -1.0528 TD
[(La)16.7(r)14.7(g)0(e)-195.4(b)0(u)21.2(t)-208(va)20.8(ri)17.3(ab)15.1(le)-197.8(am)17.7(ou)21.2(nt)13.2(s)-201.1(o)0(f)]TJ
7.472 0 0 6.641 436.535 734.23 Tm
(3)Tj
9.963 0 0 9.963 440.164 729.808 Tm
[(H-)15.7(wa)16.9(te)18.4(r)-207.2(w)0(e)16.9(r)0(e)-197(d)0(e)15.1(t)0(e)18.4(c)0(t)18.4(e)0(d)-195.4(i)0(n)]TJ
-13.1338 -1.0471 TD
[(th)13.2(e)-234.5(B)11.6(AL)-231.5(su)20(pe)20.8(rn)13.9(at)18.5(an)15.1(ts)-221.3(fr)12.4(om)-226.6(bo)21.2(th)-225.8(th)18.9(e)-234.5(s)0(m)11.2(o)0(k)21.2(e)0(r)19.2(s)-235.3(an)15.1(d)-234.1(n)0(o)15.5(n)0(s)20(m)0(o)18.1(-)]TJ
0 -1.0528 TD
[(ke)15.1(rs)-357.1(\(t)17.3(ab)15.1(le)-357.1(2\).)-367.7(There)-380.2(were)-379.3(no)-377.1(correla)-12.1(tions)-379.7(between)]TJ
7.472 0 0 6.641 519.137 713.31 Tm
0.0001 Tc
(14)Tj
9.963 0 0 9.963 526.62 708.888 Tm
0 Tc
(C-)Tj
-21.8119 -1.0471 TD
[(urea)-335.5(and)]TJ
7.472 0 0 6.641 347.187 702.879 Tm
(3)Tj
9.963 0 0 9.963 350.929 698.456 Tm
[(H-wat)-10.4(er)-333.6(levels)-335.7(in)-334(either)-336.1(subjec)-9(t)-327.5(group)-335.5(\(r)]TJ
/F8 1 Tf
16.3205 0 TD
(=)Tj
/F3 1 Tf
0.552 0 TD
(0.15)Tj
-21.0493 -1.0527 TD
[(for)-341.2(smokers,)]TJ
6.974 0 0 6.974 362.891 687.968 Tm
0.0001 Tc
(NS)Tj
9.963 0 0 9.963 371.735 687.968 Tm
0.3332 Tc
(;r)Tj
/F8 1 Tf
0.9276 0 TD
0 Tc
(=)Tj
/F3 1 Tf
0.552 0 TD
[(0.1)-7.6(7)-330.8(for)-335.5(nonsm)-8.2(okers,)]TJ
6.974 0 0 6.974 475.767 687.968 Tm
0.0001 Tc
(NS)Tj
9.963 0 0 9.963 484.668 687.968 Tm
0 Tc
(\).)Tj
/F6 1 Tf
-8.4334 -2.4583 TD
[(Discu)-10.9(ssion)]TJ
/F3 1 Tf
-8.1659 -1.7527 TD
[(Th)17.1(er)13.5(e)-558.8(r)0(e)13.5(m)0(a)17.7(i)0(n)18.8(s)-565.3(co)20.8(ns)14.4(id)18.9(er)19.2(ab)15.1(le)-550.6(co)15.1(nf)19.6(us)14.4(io)18.9(n)-564.1(r)0(e)19.2(g)0(a)15.1(r)0(d)19.6(i)0(n)18.9(g)-564.1(th)18.9(e)]TJ
-1.0015 -1.0471 TD
[(ex)15.1(pr)19.6(es)13.9(si)17.7(on)-251.9(of)-253.5(BA)18.3(L)-266.7(d)0(a)20.8(t)0(a)18.4(.)-262.1(Ma)13.2(ny)-251.9(ce)20.4(nt)13.2(re)19.2(s)-263.7(c)0(o)20.8(n)0(t)18.9(i)0(n)13.2(u)0(e)-252.3(t)0(o)-254.3(u)0(s)20(e)-262.9(th)18.9(e)]TJ
0 -1.0527 TD
[(ur)13.9(ea)-389.3(me)17.7(th)18.9(od)-394.2(in)-390.9(an)-388.9(at)18.4(te)18.4(mp)18.1(t)-401.5(t)0(o)-390.9(s)0(t)17.7(a)0(n)20.8(d)0(a)15.1(r)0(d)19.6(i)0(z)12.8(e)-393.8(re)13.5(su)20(lt)16.5(s)-400.3(f)0(r)18(o)0(m)-391.6(a)]TJ
0 -1.0471 TD
[(di)13.2(ve)20.8(rs)18.4(e)-399.5(a)0(r)19.2(r)0(a)13.5(y)-393.4(of)-390.1(st)17.7(ud)21.2(ie)18.4(s)-400.3([)0(2)19.6(2\26124].)-404.1(This)-409.1(study)-411.4(has)-407.9(clearly)]TJ
0 -1.0527 TD
[(demon)-7.4(stra)-8.6(ted)-437.6(that)-8.2(,)-432.9(durin)-7.8(g)-438.9(the)-437.6(course)-440.7(of)-441.3(a)-439.3(standardiz)-10.7(ed)]TJ
0 -1.0471 TD
[(BAL)-322.3(with)-319(minimal)-320.8(dwell)-320.2(time,)-319(there)-321.6(is)-312.4(a)-314.2(subst)-8.6(antial)-319.8(rise)]TJ
0 -1.0527 TD
[(in)-396.6(u)-6.5(rea)-397.3(levels)-398.3(in)-402.3(sequential)-404.1(aliqu)-9(ots,)-393.2(wi)-7.8(th)-396.6(a)-393.8(consequ)-7.3(ent)]TJ
T*
[(incre)-8.6(ase)-214.8(in)-208.8(the)-209.9(calcul)-10.6(ated)-211.1(level)-9.4(s)-206.8(o)0(f)-213.7(ELF)69.9(.)-205.2(I)0(n)-213.7(addition,)-218.9(it)-211.1(was)]TJ
0 -1.0471 TD
[(show)-8.2(n)-473.1(that)-474.8(there)-480.9(was)-474.4(a)-473.5(trend)-474.8(tow)-8.6(ard)-470.9(low)-8.6(er)-470.2(urea)-477.8(con-)]TJ
0 -1.0528 TD
[(cen)-8.8(trations)-238.4(in)-237.2(BAL)-242.7(fluid)-237.8(from)-242.7(smokers)-240.5(taken)-240.3(10)-234.8(min)-241.1(after)]TJ
0 -1.0471 TD
[(smok)-7.4(ing)-249.4(a)-240.2(cigar)-8.6(ette.)-248(Giv)-8.6(en)-240.9(that)-252.9(urea)-244.5(level)-9.4(s)-241(chan)-9.6(ge)-240.9(durin)-7.8(g)]TJ
0 -1.0528 TD
[(BAL)-282.5(and,)-276.2(in)-277.1(addition,)-281.5(may)-279(be)-275.1(different)-273.3(betw)-9.8(een)-276.3(smokers)]TJ
0 -1.0471 TD
[(and)-588.8(nonsm)-8.2(okers,)-593.5(it)-586.7(is)-585.5(felt)-590.3(that)-594.3(the)-585.5(urea)-591.6(method)-590.9(for)]TJ
0 -1.0527 TD
[(calcul)-10.6(ating)-339(ELF)-334.1(volum)-9.3(e)-331.2(shoul)-7.4(d)-336.5(not)-334.7(be)-332(used.)]TJ
1.0015 -1.0471 TD
[(W)37.9(i)0(t)16.5(h)0(i)18.9(n)-291(a)-291.4(y)0(e)15.1(a)0(r)-282.4(o)0(f)-282(t)0(h)18.9(e)-297.1(pu)21.2(bl)18.9(ic)12.8(at)18.4(io)18.9(n)-291(o)0(f)-282(t)0(h)18.9(e)-291.4(ur)14(ea)-281.2(me)17.7(th)13.2(od)-280.4(fo)19.6(r)]TJ
-1.0015 -1.0528 TD
[(de)15.1(te)18.4(rm)16.5(in)18.9(in)13.2(g)-404.8(E)12.2(LF)-397.5(vo)15.5(lu)18.9(me)17.7(,)-404.4(t)0(h)18.9(e)-405.2(ob)15.5(se)19.6(rv)13.9(at)18.4(io)18.9(n)-404.8(w)0(a)16.9(s)-406(ma)17.7(de)-400.3(by)]TJ
0 -1.0471 TD
(M)Tj
6.974 0 0 6.974 318.104 478.658 Tm
0.0001 Tc
[(AR)18.4(CY)]TJ
/F4 1 Tf
9.963 0 0 9.963 338.4 478.658 Tm
0 Tc
[(et)-192.1(al)18.9(.)]TJ
/F3 1 Tf
2.0998 0 TD
[([2)13.9(5])-202.3(that)-213.1(urea)-216(sampled)-217.7(at)-214.9(BAL)-214.2(increased)-218.5(with)]TJ
-5.0191 -1.0528 TD
[(prolo)-7.8(nged)-327.8(dwel)-9.8(l)-327.5(time,)-330.4(with)-330.4(probabl)-9.7(e)-325.5(sim)-9(ple)-329.4(dif)10.8(fusi)-8.2(on)-325.9(of)]TJ
0 -1.0471 TD
[(urea)-398.1(from)-396.3(the)-392(circu)-8.6(lation)-393.4(into)-394.8(the)-392(urea-f)-10.2(ree)-391.7(sali)-9.4(ne.)-389.3(This)]TJ
0 -1.0527 TD
[(led)-397.7(some)-394.7(workers)-395.3(to)-390.9(advocat)-8.9(e)-393.8(the)-392(continued)-399.4(use)-390.9(of)-390.1(the)]TJ
0 -1.0471 TD
[(met)-8.2(hod,)-321.3(but)-317.6(with)-324.7(minimized)-328.4(dwell)-320.2(time)-324.3([4].)-318.8(The)-325.5(present)]TJ
0 -1.0527 TD
[(findi)-10.2(ng)-217.8(of)-219.4(increased)-224.2(level)-9.4(s)-218.2(o)0(f)-219.4(urea)-221.7(in)-214.5(sequent)-9.7(ial)-218(aliq)-8.2(uots)-222.9(is)]TJ
0 -1.0471 TD
[(con)-8.4(sistent)-351(with)-347.5(diffusion)-346.1(taking)-351.2(place,)-349.2(but)-346.1(indi)-7.8(cates)-350(that)]TJ
0 -1.0528 TD
[(this)-236.6(occurs)-235.8(even)-231.5(in)-231.5(the)-232.7(c)-6.9(ontext)-231.7(of)-230.8(a)-234.5(minim)-9.2(ized)-233.9(dwell)-234.8(time.)]TJ
1.0015 -1.0471 TD
[(La)16.7(r)14.7(g)0(e)-269.4(b)0(u)15.5(t)-282(va)20.8(ri)17.3(ab)15.1(le)-271.8(am)17.7(ou)15.5(nt)18.9(s)-280.8(o)0(f)-270.6(r)0(a)13.5(d)0(i)18.9(o)0(l)18.9(a)0(b)15.1(e)0(l)18.4(l)0(e)18.4(d)-285.3(w)12.4(a)0(t)12.8(e)0(r)-271(w)0(e)16.9(r)0(e)]TJ
-1.0015 -1.0527 TD
[(al)12.8(so)-588.8(de)15.1(te)18.5(ct)18.4(ed)-593.8(in)-595.7(BA)12.6(L)-602.4(f)0(l)17.3(u)0(i)18.9(d)-604(i)13.9(n)-604(th)18.8(is)-596.9(st)17.7(ud)15.5(y)73.2(,)-603.6(su)20(pp)21.2(or)14(ti)16.5(ng)]TJ
0 -1.0471 TD
[(pr)13.9(ev)20.8(io)13.2(us)-344.2(st)17.7(ud)21.2(ie)12.8(s)-349.1(i)0(n)13.2(d)0(i)18.9(c)0(a)20.4(t)0(i)16.5(n)0(g)-348.6(t)0(h)18.8(a)0(t)-345.7(B)0(A)18.3(L)-357.7(is)-346.5(pr)19.6(ob)15.5(ab)20.8(ly)-345.3(ac)14.7(co)20.8(m-)]TJ
0 -1.0528 TD
[(pa)15.1(ni)18.9(ed)-269.4(by)-269(dy)21.2(na)15.1(mi)15.7(c)-274.3(m)0(o)12.4(v)0(e)20.8(m)0(e)17.7(n)0(t)13.2(s)-275.1(of)-270.6(w)12.4(a)0(t)12.8(e)0(r)47.7(,)-273.5(wi)14.9(th)-265.7(a)-280(n)0(e)20.8(t)-282(i)13.9(n)0(f)13.9(l)0(u)18.8(x)]TJ
0 -1.0471 TD
[(in)13.2(to)-396.6(B)11.6(A)0(L)-402.2(a)0(s)19.6(p)0(i)13.2(r)0(a)19.2(t)0(e)18.4(s)-406([2)13.9(9\26131].)-409.8(This)-420.5(study)55.2(,)-415.8(therefore,)-425.3(con-)]TJ
0 -1.0528 TD
[(firm)-11.8(s)-320.6(that)-326.9(compl)-9.7(ex)-326.3(interactions)-335.7(occur)-330.6(between)-331.5(BAL)-328(and)]TJ
0 -1.0471 TD
[(the)-431.9(circu)-8.6(lation.)-427.9(Unf)-7.8(ortun)-7.8(ately)58.9(,)-427.2(the)-426.2(presen)-8.2(t)-429.9(results)-429.9(using)]TJ
0 -1.0528 TD
[(radio)-8.2(label)-9.4(led)-375(water)-376.7(and)-378.3(urea)-375.3(canno)-10.3(t)-373(b)0(e)-371.8(used)-380.2(to)-373.8(indicate)]TJ
0 -1.0471 TD
[(how)-216.8(much)-211.5(movem)-10.5(ent)-209.9(is)-210(due)-213.2(to)-208.8(diffusion)-209.5(and)-213.2(how)-211.1(much)-211.5(to)]TJ
0 -1.0527 TD
[(hyd)-8(rostatic)-386.7(mecha)-8.2(nisms.)-387.7(Induced)-389(gradi)-8.2(ents)-382.6(for)-386.7(both)-381(are)]TJ
0 -1.0471 TD
[(inher)-8.2(ent)-426.2(to)-425(the)-426.2(n)-6.5(ormal)-426.7(BAL)-430.5(proces)-8.2(s,)-423.4(with)-427.2(d)-6.5(i)0(f)11.6(fusi)-8.2(on)-422.6(of)]TJ
0 -1.0528 TD
[(label)-9.4(led)-346.5(water)-348.3(into)-349.2(BAL)-345.1(flui)-9.4(d,)-342.6(in)-345.3(particula)-11.1(r)31.8(,)-347.5(likely)-347.9(to)-345.4(be)]TJ
0 -1.0471 TD
[(very)-340.8(fast.)]TJ
1.0015 -1.0527 TD
[(Th)17.1(e)-280(i)0(n)18.8(s)0(u)20(l)0(t)-268.1(o)0(f)-270.6(s)0(m)16.9(o)0(k)21.2(i)0(n)13.2(g)-273.9(re)19.2(pr)14(es)19.6(en)15.1(ts)-266.9(an)-269.4(ad)20.8(di)18.9(ti)16.5(on)15.5(al)-266.1(fa)19.2(ct)12.8(or)-264.9(in)]TJ
-1.0015 -1.0471 TD
[(an)-297.8(al)18.5(re)19.2(ad)15.1(y)-302.4(c)0(o)15.1(m)0(p)18.1(l)0(e)18.4(x)-302.4(an)15.1(d)-302.4(p)0(e)15.1(r)0(t)17.3(u)0(r)19.6(b)0(e)15.1(d)-302.4(sy)20(st)17.7(em)12(.)-302(T)12.2(he)-297.8(fi)17.3(nd)21.2(in)13.2(g)-302.4(o)0(f)]TJ
0 -1.0528 TD
[(de)15.1(cr)19.2(ea)14.7(se)19.6(d)]TJ
7.472 0 0 6.641 351.212 242.476 Tm
(14)Tj
9.963 0 0 9.963 358.469 238.053 Tm
[(C-)14.9(la)18.4(be)15.1(ll)16.5(ed)-366.1(BA)12.6(L)-380.5(u)0(r)19.6(e)0(a)-372.2(l)0(e)18.4(v)0(e)15.1(l)0(s)-369.3(i)0(n)-373.8(s)0(m)16.9(o)0(k)21.2(e)0(r)13.5(s)-377.5(fo)19.6(ll)16.5(-)]TJ
-4.9337 -1.0527 TD
[(ow)17.3(in)13.2(g)-234.1(a)0(c)14.7(u)0(t)18.9(e)-234.5(ex)15.1(po)21.2(su)14.4(re)-225.5(to)-225.8(a)-240.2(s)0(t)17.7(a)0(n)20.8(d)0(a)15.1(r)0(d)19.6(i)0(z)12.8(e)0(d)-223.9(c)0(i)18.4(g)0(a)15.1(r)0(e)19.2(t)0(t)16.5(e)-240.2(ch)20.8(al)18.5(le)18.4(ng)15.5(e)]TJ
0 -1.0471 TD
[(wa)16.9(s)-326.3(s)0(u)14.4(r)0(p)19.6(r)0(i)17.3(s)0(i)17.7(n)0(g)15.5(,)-324.7(as)-316.1(it)-319.3(su)20(gg)15.5(es)19.6(ts)-318.1(a)-325.5(d)0(e)20.8(c)0(r)13.5(e)0(a)20.4(s)0(e)14(d)-325.1(pe)20.8(rm)16.5(ea)14.7(bi)18.8(li)16.5(ty)-316.9(in)]TJ
0 -1.0527 TD
[(th)13.2(e)-223.1(d)0(i)13.2(r)0(e)19.2(c)0(t)18.5(i)0(o)18.9(n)-228.4(fr)18(om)-220.9(th)18.9(e)-228.8(b)0(l)18.9(o)0(o)15.5(d)-228.4(to)-214.5(th)13.2(e)-223.1(B)0(A)12.6(L)-226.8(co)20.8(mp)12.4(ar)19.2(tm)15.7(en)20.8(t.)-219.8(Th)17.1(e)]TJ
0 -1.0471 TD
[(ge)15.1(ne)15.1(ra)19.2(l)-338.9(f)0(i)17.3(n)0(d)15.5(i)13.9(ng)-331.6(in)-328.3(pr)13.9(ev)20.8(io)13.2(us)-327.1(st)17.7(ud)15.5(ie)18.4(s)-337.7(h)0(a)15.1(s)-337.7(be)20.8(en)-332(of)-327.5(in)13.2(cr)19.2(ea)14.7(se)19.6(d)]TJ
0 -1.0527 TD
[(pu)15.5(lm)15.7(on)21.2(ar)13.5(y)-319.4(p)0(e)20.8(r)0(m)16.5(e)0(a)14.7(b)0(i)18.9(l)0(i)16.5(t)0(y)-305.5(i)0(n)-311.2(s)0(m)16.9(o)0(k)15.5(e)0(r)19.2(s)-320.6([2)19.6(],)-327.1(wi)-7.8(th)-328.3(the)-329.4(specific)]TJ
0 -1.0471 TD
[(findi)-10.2(ng)-269(of)-276.3(B)]TJ
6.974 0 0 6.974 358.186 175.294 Tm
0.0001 Tc
(URKE)Tj
/F4 1 Tf
9.963 0 0 9.963 379.786 175.294 Tm
0 Tc
[(et)-271.8(al.)]TJ
/F3 1 Tf
2.2705 0 TD
[([28])-279.4(of)-270.6(higher)-276.4(level)-9.4(s)-269.4(o)0(f)-270.6(BAL)-276.8(urea)]TJ
-9.3439 -1.0528 TD
[(and)-418.1(ELF)-419.5(vo)-7.2(lumes)-420.7(in)-419.3(smokers.)-423(Unfortu)-9.2(nately)58.1(,)-421.5(this)-418.7(inte-)]TJ
0 -1.0471 TD
[(rest)-8.6(ing)-317.7(latter)-321.4(study)-320.4(is)-312.4(difficult)-315.9(to)-316.9(interpret)-325.3(because)-321.1(of)-316.1(the)]TJ
0 -1.0528 TD
[(heter)-8.6(ogenei)-7.8(ty)-214.5(of)-213.7(the)-215.6(smoking)-216.9(group,)-216.3(in)-214.5(whi)-8.6(ch)-212.5(24)-212.1(of)-213.7(the)-215.6(26)]TJ
0 -1.0471 TD
[(subje)-7.8(cts)-268(also)-274.5(had)-264.5(a)-268.6(varie)-8.6(ty)-265.7(of)-270.6(connect)-8.9(ive)-266.8(tissue)-273.9(disorders.)]TJ
0 -1.0528 TD
[(In)-458.4(addit)-9(ion,)-454.6(as)-458.4(for)-460.7(many)-461.8(other)-457.8(studies)-462.4(into)-463.1(pulmonary)]TJ
0 -1.0471 TD
[(perm)-8.2(eabil)-9.4(ity)-263.1(and)-264.5(smoking,)-268.5(the)-261.2(timing)-270.9(of)-259.2(the)-266.8(last)-265.5(cigar)-8.6(ette)]TJ
8.966 0 0 8.966 523.049 797.499 Tm
(287)Tj
7.472 0 0 7.472 224.334 797.499 Tm
0.0001 Tc
[(UREA)-343.9(IN)-333.2(BAL)-333.6(FROM)-342.7(HEAL)79.7(THY)-334.7(SMOKERS)]TJ
ET
endstream
endobj
20 0 obj
<<
/ProcSet [/PDF /Text ]
/Font <<
/F3 6 0 R
/F4 7 0 R
/F6 9 0 R
/F7 10 0 R
/F8 11 0 R
/F9 12 0 R
/F10 21 0 R
/F11 22 0 R
/F12 23 0 R
/F13 24 0 R
/F14 25 0 R
>>
/ExtGState <<
/GS2 13 0 R
>>
>>
endobj
27 0 obj
<<
/Length 16007
>>
stream
BT
/F3 1 Tf
9.963 0 0 9.963 58.28 380.126 Tm
0 g
/GS2 gs
0 Tc
[(relative)-323.3(to)-316.9(broncho)-7.3(scopy)-318.4(was)-320.8(not)-317.6(stated,)-319(but)-317.6(presum)-10.9(ably)]TJ
0 -1.0755 TD
[(was)-303.7(not)-306.3(standardiz)-10.7(ed)-303.5(and)-298.6(co)-7.6(uld)-300.6(have)-305.5(been)-305.5(hours)-302.5(or)-304.7(days)]TJ
T*
[(before)-611.8(in)-601.4(the)-608.3(hospital)-606.7(sett)-9.4(ing.)-602.6(Smoki)-8.6(ng)-604.7(represents)-614.3(a)]TJ
T*
[(compl)-9.7(icated)-260.9(insult)-257.6(to)-254.3(the)-255.5(lung)-261.5(and)-253.1(it)-256.7(is)-255.5(possi)-8.6(ble)-255.5(that)-258.6(acute)]TJ
T*
[(events)-481.3(may)-478.2(be)-474.3(different)-478.2(and)-475(seem)-8.2(ingly)-475.2(paradox)-7.7(ical)-480.9(to)]TJ
T*
[(chroni)-9(c)-519(sequelae.)-523.8(Some)]TJ
/F4 1 Tf
10.4535 0 TD
[(in)-516.1(vivo)]TJ
/F3 1 Tf
3.4542 0 TD
[(studies)-525(of)-521(respirato)-11.1(ry)]TJ
-13.9077 -1.0755 TD
[(clear)-9(ance)-516.4(\(lung)-519.9(to)-516.1(circu)-8.6(lation\))-520.9(have)-516(show)-8.2(n)-512.9(that)-520.4(acute)]TJ
T*
[(exposur)-8.5(e)-302.8(t)0(o)-299.8(tobacc)-8.2(o)-302.4(smok)-7.4(e)-297.1(d)-6.5(oes)-299.8(not)-306.3(increa)-9.8(se)-299(pulm)-8.6(onary)]TJ
T*
[(perm)-8.2(eability)-477.4(furt)-8.6(her)-470.9(in)-476.2(smokers)-479.5([15,)-470.9(16],)-476.6(and,)-475.4(indeed)-7.8(,)]TJ
T*
[(exposur)-8.5(e)-541.8(t)0(o)-538.8(sidestrea)-11.1(m)-538.8(smok)-7.4(e)-541.8(\(passive)-548.2(smoking\))-549.3(can)]TJ
T*
[(cause)-421.6(a)-422.3(significant)-425.5(decreas)-9.7(e)-416.6(i)0(n)-419.3(p)0(u)-7.2(lmonary)-422.6(perm)-8.2(eability)]TJ
0 -1.0698 TD
[([17].)-257(It)-255.9(has)-254.3(been)-254.2(specul)-9(ated)-256.6(that)-252.9(closu)-7.8(re)-253.9(of)-253.5(epitheli)-10.7(al)-254.7(tight)]TJ
0 -1.0755 TD
[(junctions)-368.4(may)-364.3(occur)-364.7(acutel)-10.6(y)-359.3(i)0(n)-362.4(response)-363.7(to)-362.4(some)-366.3(of)-361.6(the)]TJ
T*
[(compl)-9.7(ex)-343.4(constitu)-9.1(ents)-348.5(of)-344.6(cigarette)-353(smoke,)-350.4(resultin)-10.7(g)-342.2(i)0(n)-345.3(a)0(n)]TJ
T*
[(initial)-444.4(decreas)-9.7(e)-439.3(i)0(n)-436.4(perm)-8.2(eability)-443.2([17].)-439.1(Su)-6.4(bsequen)-7.3(tly)61.2(,)-438.6(da-)]TJ
T*
[(mage)-331.4(to)-322.6(the)-329.4(epithelium)-334.1(is)-323.8(accom)-8.2(panied)-332.1(by)-325.9(the)-323.7(incre)-8.6(ased)]TJ
T*
[(perm)-8.2(eability)-340.8(that)-338.3(is)-335.2(general)-10.5(ly)-334(describ)-11.3(ed)-332([2].)]TJ
1.0015 -1.0528 TD
[(In)-572.2(al)12.8(l)-577.9(o)0(f)-577.9(t)0(h)18.9(e)-581.6(su)20(bj)13.2(ec)20.4(ts)-574.2(st)17.7(ud)15.5(ie)18.4(d,)-570.2(th)13.2(e)-581.6(a)0(m)17.7(o)0(u)15.5(n)0(t)-573(o)0(f)-572.2(u)0(r)19.6(e)0(a)]TJ
-1.0015 -1.0698 TD
[(ca)14.7(l)13.9(c)0(u)15.1(l)0(a)18.4(t)0(e)18.4(d)-308.1(to)-299.8(be)-303.5(de)20.8(ri)17.3(ve)15.1(d)-308.1(f)0(r)18(o)0(m)-300.6(t)0(h)18.9(e)-308.5(ci)12.8(rc)19.2(ul)18.9(at)18.4(io)13.2(n)-308.1(b)0(y)-297.4(m)0(e)17.7(a)0(n)15.1(s)-309.2(of)]TJ
0 -1.0755 TD
[(ra)19.2(di)13.2(oi)18.9(so)20(to)18.8(pe)-479.9(l)13.9(a)0(b)15.1(e)0(l)18.4(l)0(i)16.5(n)0(g)-473.8(w)0(a)16.9(s)-485.7(gr)19.6(ea)14.7(te)18.4(r)-486.1(t)0(h)18.9(a)0(n)-474.3(o)0(r)-475.4(e)0(q)15.1(u)0(a)20.8(l)-486.8(to)-470.5(th)13.2(e)]TJ
T*
[(am)17.7(ou)15.5(nt)-214.5(as)13.9(sa)19.6(ye)15.1(d)-222.7(d)0(i)13.2(r)0(e)19.2(c)0(t)18.4(l)0(y)-220.2(i)0(n)-214.5(t)0(h)13.2(e)-223.1(BA)12.6(L)-226.8(s)0(u)20(p)0(e)15.1(r)0(n)19.6(a)0(t)18.5(a)0(n)15.1(t)0(.)-214.1(T)0(h)17.1(e)-228.8(la)18.4(r)20.4(g)0(e)]TJ
T*
[(di)18.9(f)20.4(f)0(e)13.5(r)0(e)19.2(n)0(c)15.1(e)0(s)-435.6(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)-444.6(pl)18.9(as)19.6(ma)-437.6(an)15.1(d)-444.6(B)11.6(AL)-436.4(co)15.1(nc)20.8(en)15.1(tr)17.3(at)18.5(io)18.8(ns)-440.9(of)]TJ
T*
[(ur)19.6(ea)-338.1(me)17.7(an)-332(th)18.9(at)-334.4(th)13.2(e)-342.6(u)0(s)20(e)-342.6(of)-333.2(an)-332(in)13.2(di)18.9(re)19.2(ct)-334.4("t)15.9(ra)19.2(ce)14.7(r")-330.4(to)-334(es)13.9(ti)22.2(ma)12(te)]TJ
T*
[(fl)17.3(ux)-735.6(is)-733.5(re)19.2(la)12.8(ti)16.5(ve)20.8(ly)-738(i)13.9(m)0(p)12.4(r)0(e)19.2(c)0(i)18.4(s)0(e)-737.2(c)0(o)20.8(m)0(p)12.4(a)0(r)19.2(e)0(d)-736(t)0(o)-732.3(t)0(h)13.2(e)-740.9(di)18.9(re)13.5(ct)]TJ
T*
[(bi)18.9(oc)15.1(he)20.8(mi)15.7(ca)14.7(l)-287.7(e)0(s)19.6(t)0(i)16.5(m)0(a)17.7(t)0(i)16.5(o)0(n)15.5(.)-284.9(Th)17.1(e)-285.7(a)0(u)15.1(t)0(h)18.9(o)0(r)19.6(s)-286.5(fe)13.5(el)-277.5(th)18.9(at)-277.5(th)13.2(e)-285.7(m)0(e)17.7(t)0(h)18.9(o)0(d)15.5(s)]TJ
T*
[(us)20(ed)-309.2(ar)19.2(e)-314.1(l)0(i)16.5(k)0(e)15.1(l)0(y)-305.5(t)0(o)-305.5(b)0(e)-303.5(r)0(o)19.6(b)0(u)15.5(s)0(t)-306.7(e)0(n)20.8(o)0(u)15.5(g)0(h)-303.1(t)0(o)-305.5(g)0(i)18.9(v)0(e)-309.2(c)0(o)20.8(n)0(f)13.9(i)0(d)18.9(e)0(n)20.8(c)0(e)-309.6(i)0(n)]TJ
25.1977 26.8537 TD
[(th)13.2(e)-501.9(g)0(e)20.8(n)0(e)15.1(r)0(a)19.2(l)-503.9(co)20.8(nc)15.1(lu)18.8(si)17.7(on)15.5(s)-502.7(o)0(f)-492.5(t)0(h)18.8(e)-501.9(pr)19.6(es)14(en)20.8(t)-503.9(s)0(t)17.7(u)0(d)15.5(y)73.2(,)-501.2(h)0(o)21.2(w)0(e)11.2(v)0(e)20.8(r)60.2(.)]TJ
0 -1.0755 TD
[(In)13.9(de)20.8(ed)15.1(,)-290.6(s)0(i)17.7(m)0(i)15.7(l)0(a)18.5(r)-292.6(tr)17.3(en)15.1(ds)-281.6(we)16.9(re)-282.4(ob)15.5(se)19.6(rv)19.6(ed)-286.5(us)20(in)18.8(g)-291(b)0(o)15.5(t)0(h)-282.7(m)0(e)17.7(a)0(s)14(u)0(r)19.6(e)0(-)]TJ
T*
[(me)12(nt)-242.9(ap)15.1(pr)19.6(oa)15.1(ch)20.8(es)14(.)-250.8(T)0(h)17.1(e)-251.6(pr)13.9(es)19.6(en)15.1(t)-253.5(d)0(e)20.8(s)0(i)17.7(g)0(n)-246.2(i)0(n)18.8(d)0(i)13.2(c)0(a)20.4(t)0(e)18.4(s)-258(th)18.9(at)-243.3(st)17.7(ud)15.5(ie)18.4(s)]TJ
T*
[(in)13.2(to)-464.8(th)13.2(e)-473.5(d)0(y)15.5(n)0(a)15.1(m)0(i)15.7(c)0(s)-464.1(o)0(f)-469.7(p)0(u)15.5(l)0(m)15.7(o)0(n)21.2(a)0(r)13.5(y)-478.8(pe)20.8(rm)16.5(ea)14.7(bi)18.9(li)16.5(ty)-470.5(fr)18(om)-471.3(th)18.9(e)]TJ
ET
1 i 
58.28 758.834 478.205 -0.51 re
f
58.28 732.926 478.205 -0.51 re
f
58.28 442.035 478.205 -0.51 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 772.667 Tm
[(Table)-331.9(2.)-336.7(\261)-333.2(Individual)-490.1(bronchoalveolar)-485.6(lavage)-488.3(\(BAL\))-491.2(fluid)-486.8(and)-487.4(plasma)-485.5(14C)-492.1(and)-487.4(3H)-487.7(counts*,)-487.8(BAL)-487(return)-488.8(volumes)-484.9(and)]TJ
0 -1.0559 TD
[(calculated)-334.6(water)-333.3(flux)-333.2(and)-335.7(epithelial)-335.8(lining)-332.9(fluid)-335.1(\(ELF\))-334.6(volumes)-333.2(for)-332.5(all)-333.5(individuals)-337.6(studied)]TJ
/F3 1 Tf
0 -1.7072 TD
(ID**)Tj
6.725 0 0 5.977 104.712 751.861 Tm
0.0001 Tc
(14)Tj
8.966 0 0 8.966 111.458 747.893 Tm
0 Tc
[(C)-333(urea)-333.6(BAL)]TJ
0.1518 -1.0559 TD
[(fluid)-332(dpm)]TJ
6.725 0 0 5.977 172.8 751.861 Tm
0.0001 Tc
(14)Tj
8.966 0 0 8.966 179.49 747.893 Tm
0 Tc
[(C)-339.3(urea)-333.6(plasma)]TJ
1.6566 -1.0559 TD
(dpm)Tj
6.725 0 0 5.977 248.145 751.861 Tm
0 Tw
(3)Tj
8.966 0 0 8.966 251.49 747.893 Tm
(H)Tj
6.725 0 0 5.977 257.953 746.362 Tm
(2)Tj
8.966 0 0 8.966 261.298 747.893 Tm
[(O)-337.9(BAL)-332.5(fluid)]TJ
0.999 -1.0559 TD
(dpm)Tj
6.725 0 0 5.977 324.624 751.861 Tm
(3)Tj
8.966 0 0 8.966 327.968 747.893 Tm
(H)Tj
6.725 0 0 5.977 334.431 746.362 Tm
(2)Tj
8.966 0 0 8.966 337.776 747.893 Tm
[(O)-337.9(plasma)]TJ
0.3098 -1.0559 TD
(dpm)Tj
5.3682 1.0559 TD
[(BAL)-332.4(return)]TJ
1.6503 -1.0559 TD
(mL)Tj
4.8433 1.0559 TD
[(W)70.8(ater)-336(flux)-330.1(***)]TJ
2.3584 -1.0559 TD
(mL)Tj
5.5578 1.0559 TD
(ELF)Tj
0.1897 -1.0559 TD
(mL)Tj
-51.4495 -2.0044 TD
[(NS)-336(1:1)-4686.1(39)-6751.9(445)-6713.4(3005)-5840.3(7294)-5315.5(15)-6334.6(6.2)-4244.6(0.4)]TJ
0 -1.0559 TD
[(NS)-336(1:2)-4686.1(33)-6751.9(472)-6713.4(2651)-5840.3(7522)-5315.5(20)-6334.6(7.0)-4244.6(0.4)]TJ
T*
[(NS)-336(1:3)-4686.1(46)-6751.9(390)-6713.4(3403)-5840.3(7019)-5315.5(16)-6334.6(7.8)-4244.6(0.6)]TJ
T*
[(NS)-336(2:1)-5185.7(2)-6752.4(299)-6713.4(1694)-5840.3(5026)-5315.5(17)-6334.6(5.7)-4244.6(0.1)]TJ
0 -1.0496 TD
[(NS)-336(2:2)-5185.7(7)-6752.4(314)-6713.4(2691)-5840.3(5241)-5315.5(36)-5835(18.5)-4244.1(0.3)]TJ
0 -1.0559 TD
[(NS)-336(2:3)-4686.1(10)-6751.9(302)-6713.4(3585)-5840.3(5062)-5315.5(55)-5835(39.0)-4244.1(0.5)]TJ
T*
[(NS)-336(3:1)-4686.1(13)-6751.9(280)-7212.9(582)-5840.9(3763)-5315.5(25)-6334.6(3.9)-4244.6(0.3)]TJ
T*
[(NS)-336(3:2)-4686.1(36)-6751.9(273)-6713.4(1662)-5840.3(3660)-5315.5(43)-5835(19.5)-4244.1(1.4)]TJ
T*
[(NS)-336(3:3)-4686.1(46)-6751.9(274)-6713.4(1867)-5840.3(3636)-5315.5(50)-5835(25.7)-4244.1(2.3)]TJ
T*
[(NS)-336(4:1)-4686.1(12)-6751.9(208)-6713.4(2592)-5840.3(8617)-5315.5(17)-6334.6(5.1)-4244.6(0.1)]TJ
T*
[(NS)-336(4:2)-4686.1(16)-6751.9(364)-6713.4(5041)-5840.3(6822)-5315.5(28)-5835(20.7)-4244.1(0.3)]TJ
T*
[(NS)-336(4:3)-4686.1(16)-6751.9(157)-6713.4(4051)-5840.3(7039)-5315.5(25)-5835(14.4)-4244.1(0.3)]TJ
T*
[(NS)-336(5:1)-5185.7(6)-6752.4(664)-7212.9(333)-5840.9(7259)-5815(5)-6335.1(0.2)-4244.6(0.1)]TJ
T*
[(NS)-336(5:2)-4686.1(30)-6751.9(572)-6713.4(3355)-5840.3(6641)-5315.5(36)-5835(18.2)-4244.1(1.0)]TJ
T*
[(NS)-336(5:3)-4686.1(31)-6751.9(430)-6713.4(2466)-5840.3(6423)-5315.5(50)-5835(19.2)-4244.1(1.3)]TJ
T*
[(SM)-333.4(1:1)-4521.8(20)-6751.9(724)-6713.4(1644)-5840.3(8756)-5315.5(25)-6334.6(4.7)-4244.6(0.3)]TJ
T*
[(SM)-333.4(1:2)-4521.8(29)-6751.9(770)-6713.4(2689)-5840.3(9735)-5315.5(40)-5860.3(1)25.8(1.0)-4244.6(0.8)]TJ
T*
[(SM)-333.4(1:3)-4521.8(28)-6751.9(773)-6713.4(3216)-5840.3(9224)-5315.5(45)-5835(15.7)-4244.1(0.9)]TJ
T*
[(SM)-333.4(2:1)-5021.3(8)-6752.4(665)-7212.9(662)-5840.9(6442)-5315.5(16)-6334.6(1.6)-4244.6(0.1)]TJ
T*
[(SM)-333.4(2:2)-4521.8(20)-6751.9(572)-6713.4(2128)-5840.3(6294)-5315.5(37)-5835(12.5)-4244.1(0.6)]TJ
T*
[(SM)-333.4(2:3)-4521.8(29)-6751.9(441)-6713.4(2874)-5840.3(6261)-5315.5(47)-5835(21.6)-4244.1(1.2)]TJ
T*
[(SM)-333.4(3:1)-4521.8(12)-6751.9(581)-7212.9(969)-5840.9(7874)-5315.5(13)-6334.6(1.6)-4244.6(0.2)]TJ
T*
[(SM)-333.4(3:2)-4521.8(20)-6751.9(581)-6713.4(2400)-5840.3(6437)-5315.5(44)-5835(16.4)-4244.1(1.0)]TJ
0 -1.0496 TD
[(SM)-333.4(3:3)-4521.8(17)-6751.9(523)-6713.4(2438)-5840.3(6741)-5315.5(46)-5835(16.6)-4244.1(1.0)]TJ
0 -1.0559 TD
[(SM)-333.4(4:1)-4521.8(24)-6751.9(559)-7212.9(728)-5840.9(4294)-5315.5(12)-6334.6(2.0)-4244.6(0.4)]TJ
T*
[(SM)-333.4(4:2)-4521.8(37)-6751.9(652)-6713.4(1456)-5840.3(4800)-5315.5(20)-6334.6(6.1)-4244.6(0.7)]TJ
T*
[(SM)-333.4(4:3)-4521.8(49)-6751.9(690)-6713.4(2295)-5840.3(4941)-5315.5(23)-5835(10.7)-4244.1(1.2)]TJ
T*
[(SM)-333.4(5:1)-5021.3(8)-6752.4(564)-6713.4(2290)-5840.3(8339)-5315.5(16)-6334.6(4.4)-4244.6(0.1)]TJ
T*
[(SM)-333.4(5:2)-4521.8(17)-6751.9(652)-6713.4(4715)-5840.3(7506)-5315.5(50)-5835(31.4)-4244.1(0.5)]TJ
T*
[(SM)-333.4(5:3)-4521.8(16)-6751.9(690)-6713.4(4315)-5840.3(8658)-5315.5(52)-5835(25.9)-4244.1(0.6)]TJ
0 -1.9475 TD
[(*:)-235.3(all)-237(isotope)-242.4(counts)-234.2(are)-239.3(background-corrected)-241.3(\()]TJ
6.725 0 0 5.977 227.112 432.567 Tm
0.0001 Tc
(14)Tj
8.966 0 0 8.966 233.858 428.542 Tm
0 Tc
[(C:)-233.7(5;)]TJ
6.725 0 0 5.977 253.361 432.567 Tm
(3)Tj
8.966 0 0 8.966 256.762 428.542 Tm
[(H:10\))-238(and)-232.2(expressed)-238.3(in)-235.3(quench-corrected)-242.3(disintegrations)-241.1(per)-239.5(minute)-237.3(\(dpm\);)-237.1(**:)]TJ
-22.1365 -1.0559 TD
[(the)-297.8(number)-296.7(after)-304.8(the)-297.8(colon)-296.8(identifies)-303.3(the)-297.8(BAL)-300.8(aliquot.)-297.1(Hence,)-300.1(NS)-298(1:1)-298(is)-299.7(nonsmoker)-296.4(\(NS\))-299(1)-296.7(aliquot)-300.5(1;)-298.5(***:)-297.5(derived)-296.5(value)-302.9(for)-297.6(labelled)]TJ
T*
[(water)-338.8(calculated)-336(from)-330.6(the)-335.8(BAL)-332.4(and)-333.4(plasma)]TJ
6.725 0 0 5.977 218.494 413.631 Tm
(3)Tj
8.966 0 0 8.966 221.896 409.606 Tm
[(H)-331.6(counts.)-332(ELF:)-334.7(epithelial)-341.2(lining)-332.9(fluid;)-333.9(ID:)-333.9(identifier;)-342.9(SM:)-335.2(smoker)49.8(.)]TJ
ET
0 0 0 1 K
0 J 0 j 0.5 w 3.864 M []0 d
/GS3 gs
516.617 210.326 m
492.317 212.43 l
467.716 205.632 l
522.213 216.222 m
497.311 218.326 l
467.115 208.523 l
490.814 233.124 m
467.115 204.43 l
413.519 219.528 m
388.317 212.43 l
363.115 201.424 l
418.814 254.233 m
393.011 238.534 l
367.508 205.031 l
417.913 290.626 m
392.765 242.375 l
366.661 256.386 l
S
BT
/F20 1 Tf
10 0 0 10 338.551 194.313 Tm
0 0 0 1 k
/GS4 gs
(0.0)Tj
0 2.4709 TD
(0.2)Tj
0 2.5419 TD
(0.4)Tj
0 2.5135 TD
(0.6)Tj
0 2.59 TD
(0.8)Tj
0 2.4993 TD
(1.0)Tj
ET
/GS3 gs
353.993 324.261 m
353.993 197.458 l
354.233 324.069 m
351.491 324.069 l
354.233 298.621 m
351.491 298.621 l
354.233 273.285 m
351.491 273.285 l
354.233 247.695 m
351.491 247.695 l
354.233 222.447 m
351.491 222.447 l
354.233 197.71 m
351.491 197.71 l
361.771 191.878 m
424.636 191.878 l
362.098 192.088 m
362.098 189.346 l
388.211 192.088 m
388.211 189.346 l
413.954 192.088 m
413.954 189.346 l
S
BT
10 0 0 10 359.902 179.923 Tm
/GS4 gs
2.1426 Tc
[(12)8.6(3)]TJ
-4.0385 14.6906 TD
0 Tc
(a\))Tj
ET
/GS3 gs
457.993 324.261 m
457.993 197.458 l
458.232 324.069 m
455.491 324.069 l
458.232 298.621 m
455.491 298.621 l
458.232 273.285 m
455.491 273.285 l
458.232 247.695 m
455.491 247.695 l
458.232 222.447 m
455.491 222.447 l
458.232 197.71 m
455.491 197.71 l
465.771 191.878 m
528.635 191.878 l
466.097 192.088 m
466.097 189.346 l
492.21 192.088 m
492.21 189.346 l
517.954 192.088 m
517.954 189.346 l
S
BT
10 0 0 10 463.901 179.923 Tm
/GS4 gs
2.1426 Tc
[(12)8.6(3)]TJ
-2.0885 14.6906 TD
0 Tc
(b\))Tj
/F22 1 Tf
6 0 0 6 411.175 316.075 Tm
(n)Tj
ET
0 0 0 0 k
3.864 M 
/GS3 gs
416.869 293.878 4 -4 re
B
BT
6 0 0 6 411.175 295.567 Tm
0 0 0 1 k
/GS4 gs
(n)Tj
-4.3314 -0.5819 TD
(n)Tj
-4.2505 -4.2004 TD
(n)Tj
4.2505 -2.316 TD
(n)Tj
-4.2004 -3.7495 TD
(n)Tj
0.0501 -5.1521 TD
(n)Tj
4.2004 1.7341 TD
(n)Tj
4.3815 1.183 TD
(n)Tj
ET
0 0 0 0 k
/GS3 gs
364.661 258.386 4 -4 re
B
390.765 244.375 4 -4 re
B
390.765 240.883 4 -4 re
B
417.169 256.883 4 -4 re
B
365.563 206.179 4 -4 re
B
3.864 M 
412.618 318.233 m
388.017 294.834 l
362.815 233.725 362.815 233.424 v
363.416 268.43 m
387.416 255.435 l
412.918 296.823 l
S
BT
6 0 0 6 463.568 220.562 Tm
0 0 0 1 k
/GS4 gs
(n)Tj
0 -1.133 TD
(n)Tj
T*
(n)Tj
0 -0.551 TD
(n)Tj
4.3006 4.4008 TD
(n)Tj
0 -0.3006 TD
(n)Tj
0 -1.3333 TD
(n)Tj
0 -1.684 TD
(n)Tj
4.3315 7.5992 TD
(n)Tj
0 -2.9981 TD
(n)Tj
0 -2.5164 TD
(n)Tj
0 -2.3352 TD
(n)Tj
ET
0 0 0 0 k
3.864 M 
/GS3 gs
521.169 218.086 4 -4 re
B
494.764 220.976 4 -4 re
B
469.863 210.386 4 -4 re
B
3.864 M 
517.519 257.424 m
491.839 231.948 l
466.514 222.834 l
516.918 239.135 m
492.016 230.534 l
467.115 215.921 m
491.115 221.933 l
517.827 224.549 l
S
BT
/F20 1 Tf
10 0 0 10 378.388 169.924 Tm
0 0 0 1 k
/GS4 gs
[(Aliquot)-8093(Aliquot)]TJ
0 8 -8 0 328.388 226.589 Tm
(14)Tj
0 10 -10 0 331.222 233.885 Tm
(C urea )Tj
/F17 1 Tf
2.689 0 TD
(m)Tj
/F20 1 Tf
0.576 0 TD
(mol\341mL)Tj
0 8 -8 0 328.388 293.414 Tm
(-1)Tj
/F3 1 Tf
7.97 0 0 7.97 309.316 155.282 Tm
0 g
/GS2 gs
[(Fig.)-334.3(1.)-324.1(\261)-332.2(Concentratio)9.1(ns)-217.5(of)-223.6(urea)-217.4(calculate)9.7(d)-218.4(a)0(s)-223.6(being)-211.4(due)-220.3(to)-218.7(movement)-211.7(of)]TJ
0 -1.0599 TD
[(radiolabelled)-405.1(urea)-416.5(from)-411.9(the)-407.6(circulation)-410.3(between)-406.8(isotope)-409.9(injection)-408.3(and)]TJ
0 -1.067 TD
[(aspiration)-319.8(of)-323.2(bronchoalv)13.4(eolar)-317.2(lavage)-321(\(BAL\))-319.8(fluid)-321.7(in)-318.3(three)-317.2(60)-323(mL)-318.9(BAL)]TJ
0 -1.0599 TD
[(aspirates)-362.4(in:)-368.4(a\))-357.7(five)-370.2(nonsmok)13.2(ing;)-366.2(and)-355.5(b\))-365.9(five)-363(smoking)-359(normal)-359.1(healthy)]TJ
T*
[(subjects.)-250.4(The)-258.6(results)-254.8(for)-250.1(each)-258.9(individua)12.8(l)-263.5(aspirated)-247.4(aliquot)-254.6(are)-255(shown.)]TJ
/F15 1 Tf
27.3998 0 TD
(u)Tj
/F3 1 Tf
0.8322 0 TD
(:)Tj
-28.232 -1.067 TD
[(grass)-332.5(pollen-sens)10.7(itive)-330(\(atopic\))-327.7(individuals.)]TJ
8.966 0 0 8.966 58.28 797.499 Tm
(288)Tj
7.472 0 0 7.472 269.121 797.499 Tm
0.0001 Tc
[(C.)-335.8(W)102.5(ARD)-333.4(ET)-263.8(AL.)]TJ
ET
endstream
endobj
28 0 obj
<<
/ProcSet [/PDF /Text ]
/Font <<
/F2 5 0 R
/F3 6 0 R
/F4 7 0 R
/F15 29 0 R
/F17 30 0 R
/F20 31 0 R
/F22 32 0 R
>>
/ExtGState <<
/GS2 13 0 R
/GS3 33 0 R
/GS4 34 0 R
>>
>>
endobj
36 0 obj
<<
/Length 20297
>>
stream
BT
/F3 1 Tf
9.963 0 0 9.963 58.28 529.568 Tm
0 g
/GS2 gs
0 Tc
[(bl)18.9(oo)15.5(d)-666.6(t)0(o)-658.3(t)0(h)18.8(e)-667(ai)12.8(rw)15.7(ay)-656.3(co)15.1(m)13.2(p)0(a)15.1(r)0(t)17.3(m)0(e)17.7(n)0(t)-658.3(a)0(r)13.5(e)-667(pr)19.6(ac)14.7(ti)16.5(ca)20.4(bl)18.9(e)-672.7(i)0(n)]TJ
0 -1.0527 TD
[(hu)15.5(ma)17.7(ns)20(.)]TJ
1.0015 -1.0471 TD
[(In)-327.5(co)15.1(nc)20.8(lu)18.9(si)12(on)21.2(,)-336.1(t)0(h)18.9(e)-336.9(pr)13.9(es)19.6(en)20.8(t)-338.9(w)0(o)17.3(r)0(k)-327.5(r)0(e)13.5(-)0(e)19.2(m)0(p)18.1(h)0(a)15.1(s)0(i)17.7(z)0(e)20.4(s)-337.7(th)18.9(e)-336.9(f)0(a)13.5(c)0(t)]TJ
-1.0015 -1.0528 TD
[(th)18.9(at)-237.6(ur)19.6(ea)-241.3(ca)20.4(nn)15.5(ot)-237.2(be)-235.2(us)20(ed)-240.9(as)-236.4(a)-245.9(d)0(e)20.8(n)0(o)15.5(m)0(i)15.7(n)0(a)20.8(t)0(o)18.9(r)-247.1(of)-236.4(EL)18.7(F)-250.4(v)0(o)21.2(l)0(u)18.9(m)0(e)12(.)]TJ
0 -1.0471 TD
[(Th)17.1(is)-278.2(is)-272.6(be)15.1(ca)20.4(us)14.4(e)-285.7(B)11.6(AL)-282.7(ca)20.4(us)20(es)-282(ac)20.4(ut)18.9(e)-285.7(c)0(h)15.1(a)0(n)20.8(g)0(e)15.1(s)-286.5(in)-277.1(t)13.9(h)0(e)-280.8(p)0(u)21.2(t)0(a)18.4(t)0(i)16.5(v)0(e)]TJ
0 -1.0528 TD
[(de)15.1(no)21.2(mi)15.7(na)15.1(to)18.9(r)-372.2(b)0(e)15.1(i)0(n)18.9(g)-370.7(sa)13.9(mp)18.1(le)18.4(d,)-365.3(an)15.1(d)-370.7(b)0(e)15.1(c)0(a)20.4(u)0(s)14.4(e)-371.1(th)18.9(er)13.5(e)-371.1(a)0(r)13.5(e)-371.1(ad)15.1(di)18.9(-)]TJ
0 -1.0471 TD
[(ti)16.5(on)21.2(al)-163.6(co)15.1(nf)19.6(ou)15.5(nd)21.2(er)13.5(s)-172.7(t)0(o)-163.2(i)0(t)22.2(s)-172.7(us)14.4(e,)-160.9(wh)17.3(ic)18.4(h)-171.5(i)0(n)18.9(c)0(l)12.8(u)0(d)21.2(e)-171.9(sm)16.9(ok)15.5(in)18.9(g.)-160.5(Th)17.1(es)13.9(e)]TJ
0 -1.0527 TD
[(ef)24.9(fe)19.2(ct)18.4(s)-127.1(m)0(a)17.7(y)-131.7(no)21.2(t)-128.3(b)0(e)-115.7(u)0(n)15.5(i)0(f)17.3(o)0(r)19.6(m)-129.1([1)13.9(6,)-115(17)15.5(,)-125.6(2)0(8)21.2(])0(,)-122.2(a)0(n)20.8(d)-126(th)13.2(e)-126.4(p)0(r)19.6(e)0(s)13.9(e)0(n)20.8(t)-128.3(st)17.7(ud)15.5(y)]TJ
0 -1.0471 TD
[(wo)17.3(ul)18.9(d)-302.4(s)0(u)20(g)0(g)15.5(e)0(s)19.6(t)-299.1(th)18.8(at)-294.5(ac)20.4(ut)18.9(e)-302.8(e)0(f)30.6(f)0(e)13.5(c)0(t)18.5(s)-297.9(ma)17.7(y)-302.4(b)0(e)-286.5(d)0(i)13.2(f)20.4(fe)19.2(re)13.5(nt)-288.4(to)-288.4(mo)12.4(re)]TJ
0 -1.0528 TD
[(ch)15.1(ro)19.6(ni)18.9(c)-206(c)0(h)15.1(a)0(n)20.8(g)0(e)15.1(s)-201.1(in)-197.4(pe)15.1(rm)16.5(ea)20.4(bi)13.2(l)13.9(i)0(t)16.5(y)67.5(.)-199.6(D)0(i)14.9(s)0(e)13.9(a)0(s)19.6(e)-206(pr)19.6(oc)15.1(es)19.6(se)19.6(s)-206.8(a)0(r)19.2(e)-206(al)12.8(so)]TJ
0 -1.0471 TD
[(li)16.5(ke)20.8(ly)-168.9(to)-163.2(af)30.6(fe)13.5(ct)-163.6(pe)20.8(rm)16.5(ea)14.7(bi)18.9(li)16.5(ty)-163.2(an)15.1(d)-171.5(s)0(u)20(c)0(h)-167(c)0(o)15.1(n)0(f)19.6(o)0(u)21.2(n)0(d)15.5(e)0(r)19.2(s)-172.7(ma)12(y)-171.5(w)0(e)16.9(l)0(l)]TJ
0 -1.0528 TD
[(in)18.9(cl)18.4(ud)15.5(e)-325.5(c)0(o)20.8(m)0(m)14.9(o)0(n)15.5(l)0(y)-316.9(o)0(c)20.8(c)0(u)15.1(r)0(r)18(i)0(n)18.9(g)-325.1(va)20.8(ri)17.3(ab)15.1(le)18.4(s)-326.3(s)0(u)20(c)0(h)-314.9(a)0(s)-316.1(a)0(t)18.4(o)0(p)15.5(y)73.2(.)]TJ
1.0015 -1.0471 TD
[(He)16.9(nc)15.1(e,)-263.3(th)18.9(e)-274.3(a)0(u)15.1(t)0(h)18.9(o)0(r)19.6(s)-275.1(wo)17.3(ul)18.9(d)-273.9(s)0(u)14.4(p)0(p)21.2(o)0(r)13.9(t)-270.6(th)18.9(e)-274.3(v)0(i)13.2(e)0(w)79.5(,)-273.5(ou)21.2(tl)16.5(in)18.8(ed)-263.7(by)]TJ
-1.0015 -1.0528 TD
[(th)18.9(e)-336.9(E)0(u)17.1(r)0(o)19.6(p)0(e)15.1(a)0(n)-326.3(R)11.6(es)13.9(pi)18.9(ra)19.2(to)13.2(ry)-321.8(So)16.3(ci)18.4(et)18.4(y)-336.5(t)0(a)18.4(s)0(k)-327.1(f)0(o)19.6(r)0(c)13.5(e)-336.9(on)-325.9(m)13.2(e)0(a)14.7(s)0(u)20(r)0(e)13.5(-)]TJ
0 -1.0471 TD
[(me)17.7(nt)-351(of)-350.2(ac)14.7(el)18.4(lu)18.9(la)18.4(r)-360.9(c)0(o)15.1(m)0(p)18.1(o)0(n)21.2(e)0(n)15.1(t)0(s)-352.2(i)0(n)-351(b)0(r)19.6(o)0(n)21.2(c)0(h)15.1(o)0(a)15.1(l)0(v)18.9(e)0(o)20.8(l)0(a)12.8(r)-355.2(la)12.8(va)20.8(ge)15.1(,)]TJ
0 -1.0528 TD
[(th)18.9(at)-300.2(re)19.2(su)14.4(lt)16.5(s)-303.6(a)0(r)13.5(e)-308.5(mo)18.1(st)-301(me)17.7(an)20.8(in)13.2(gf)19.6(ul)18.9(ly)-299.8(ex)15.1(pr)19.6(es)19.6(se)13.9(d)-308.1(p)0(e)20.8(r)-309.7(mi)15.7(ll)16.5(il)16.5(it)16.5(re)]TJ
0 -1.0471 TD
[(of)-321.8(br)19.6(on)15.5(ch)20.8(oa)15.1(lv)18.9(eo)15.1(la)18.4(r)-326.7(l)0(a)12.8(v)0(a)20.8(g)0(e)-320.6(a)0(s)13.9(p)0(i)18.9(r)0(a)19.2(t)0(e)-323([)0(3)19.6(2].)-333.6(Bronchoal)-10.7(veolar)]TJ
0 -1.0527 TD
[(lavage)-309.8(fluid)-306.1(solute)-306.8(meas)-8.2(urements)-311.1(remain)-308.4(a)-302.8(powerful)-311.9(and)]TJ
0 -1.0471 TD
[(genuin)-7.4(ely)-494.5(q)-6.5(uantitative)-505.2(tool)-497.2(that)-503.3(will)-497.8(conti)-9(nue)-497.8(to)-493.3(yiel)-8.2(d)]TJ
0 -1.0528 TD
[(valuab)-7.8(le)-562(data,)-558.6(provi)-7.8(ding)-563.1(that)-560.2(know)-7(n)-558.4(confoun)-7.3(ders)-563.9(are)]TJ
0 -1.0471 TD
[(avoide)-7.8(d.)]TJ
/F6 1 Tf
8.966 0 0 8.966 151.257 282.387 Tm
[(Referenc)8.7(es)]TJ
/F3 1 Tf
-10.3696 -2.2762 TD
[(1.)-1766.5(Hopkins)-344.7(SR,)-346.6(Schoene)-348.4(RB,)-346.4(Henderson)-348.2(WR,)-347.3(Spragg)-350.3(RG,)]TJ
2.5165 -1.1128 TD
[(Martin)-218.1(TR,)-225.1(W)77.1(est)-223.1(JB.)-222.8(Intense)-221.8(exercise)-220.9(impairs)-226.3(the)-221.9(integrity)]TJ
T*
[(of)-271.8(the)-278.8(pulmonary)-278.6(blood-gas)-277.9(barrier)-279.5(in)-273.3(elite)-282.4(athletes.)]TJ
/F4 1 Tf
20.7834 0 TD
[(Am)-271.3(J)]TJ
-20.7834 -1.1065 TD
[(Respir)-333.8(Crit)-331.1(Car)27.2(e)-334.4(Med)]TJ
/F3 1 Tf
9.2251 0 TD
[(1997;)-328.6(155:)-335.5(1090\2611094.)]TJ
-11.7416 -1.1128 TD
[(2.)-1766.5(Huchon)-626(GJ.)-632.3(Radioaerosol)-637.1(Studies)-633(of)-625.9(the)-632.9(Pulmonary)]TJ
2.5165 -1.1128 TD
(Epithelium.)Tj
/F4 1 Tf
4.8939 0 TD
(In)Tj
/F3 1 Tf
0.822 0 TD
[(:)-248.5(Effros)-244.8(RM)-251(and)-251.2(Chang)-248.5(HK,)-248.7(eds.)-255.3(Fluid)-247.4(and)]TJ
-5.7159 -1.1128 TD
[(solute)-249.3(transport)-249.7(in)-248(the)-247.2(Airspaces)-250.3(of)-252.9(the)-247.2(Lungs.)-245.3(New)-251.4(Y)92(ork,)]TJ
0 -1.1065 TD
[(Marcel)-335.4(Dekker)30.9(,)-331.7(1994;)-334.9(399\261449.)]TJ
-2.5165 -1.1128 TD
[(3.)-1766.5(Fick)-428.7(RB,)-435(Metzger)-429.7(WJ,)-432.3(Richerson)-434.2(HB,)]TJ
/F4 1 Tf
18.9624 0 TD
[(et)-431.1(al)]TJ
/F3 1 Tf
1.9095 0 TD
[(.)-432.9(Increased)]TJ
-18.3554 -1.1128 TD
[(bronchovascular)-395.3(permeability)-397.6(after)-399.7(aller)9.9(gen)-396.6(exposure)-396(in)]TJ
T*
[(sensitive)-358.6(asthmatics.)]TJ
/F4 1 Tf
8.5865 0 TD
[(J)-359.7(Appl)-357.9(Physiol)]TJ
/F3 1 Tf
6.3608 0 TD
[(1987;)-353.9(63\(3\):)-361.7(1)32.1(147\261)]TJ
-14.9474 -1.1065 TD
[(1)32.1(155.)]TJ
-2.5165 -1.1128 TD
[(4.)-1766.5(Jones)-366.3(KP)100.3(,)-369.6(Edwards)-371.9(JH,)-373.1(Reynolds)-377(SP)105(,)-369.6(Peters)-372.7(TJ,)-373.3(Davies)]TJ
2.5165 -1.1128 TD
[(BH.)-256.5(A)-255.7(comparison)-260.1(of)-259.2(albumin)-255.8(and)-257.5(urea)-264(as)-252.9(reference)-262.7(mar-)]TJ
0 -1.1065 TD
[(kers)-391.9(in)-399.7(bronchoalveolar)-396.5(lavage)-403.3(fluid)-395.2(from)-400.1(patients)-395.8(with)]TJ
0 -1.1128 TD
[(interstitial)-334.7(lung)-335.5(disease.)]TJ
/F4 1 Tf
9.8511 0 TD
[(Eur)-331.9(Respir)-333.8(J)]TJ
/F3 1 Tf
5.5073 0 TD
[(1990;)-334.9(3:)-330.2(152\261156.)]TJ
10.123 73.5671 TD
[(5.)-1766.5(Majno)-215.3(G,)-214.4(Palde)-212.9(GE.)-211(Studies)-215.7(on)-214(inflammation)-216.3(I.)-218.4(The)-210.4(effect)]TJ
2.5165 -1.1191 TD
[(of)-360.4(histamine)-371.9(and)-358.7(serotonin)-368.8(on)-365.7(vascular)-366.5(permeability:)-367.8(an)]TJ
0 -1.1128 TD
[(electron)-538.4(microscopic)-540(study)62.2(.)]TJ
/F4 1 Tf
11.9629 0 TD
[(J)-536.7(Biophys)-534.4(Biochem)-542.6(Cytol)]TJ
/F3 1 Tf
-11.9629 -1.1192 TD
[(1961;)-334.9(1)32.1(1)0(:)-330.2(571\261604.)]TJ
-2.5165 -1.1065 TD
[(6.)-1766.5(Persson)-510.3(CGA,)-505.9(Andersson)-514(M,)-508.9(Greiff)-498.5(L,)]TJ
/F4 1 Tf
19.6263 0 TD
[(et)-507(al)]TJ
/F3 1 Tf
1.9854 0 TD
[(.)-508.8(Airway)]TJ
-19.0952 -1.1192 TD
[(permeability)57.7(.)]TJ
/F4 1 Tf
5.6717 0 TD
[(Clinical)-496.8(and)-498(Experimental)-501.5(Aller)31.3(gy)]TJ
/F3 1 Tf
14.8778 0 TD
(1995;)Tj
-20.5495 -1.1128 TD
[(23:)-336(807\261814.)]TJ
-2.5165 -1.1128 TD
[(7.)-1766.5(Schmekel)-529.2(B,)-525.6(W)77.1(ollmer)-529.1(P)103.1(,)-521.4(V)98.4(enge)-522.3(P)103.1(,)-527.7(Linden)-521.1(M,)-527.9(Blom-)]TJ
2.5165 -1.1128 TD
[(Bulow)-330.3(B.)-335.9(T)34.9(ransfer)-335.2(of)-335.1(99mT)59.9(cDTP)85.4(A)-331.6(and)-333.4(bronchoalveolar)]TJ
0 -1.1191 TD
[(lavage)-409.6(findings)-407.5(in)-406(patients)-408.5(with)-410.7(asymptomatic)-410(extrinsic)]TJ
0 -1.1128 TD
[(aller)9.9(gic)-335.8(alveolitis.)]TJ
/F4 1 Tf
7.4674 0 TD
(Thorax)Tj
/F3 1 Tf
3.2057 0 TD
[(1990;)-334.9(45:)-329.7(525\261529.)]TJ
-13.1896 -1.1128 TD
[(8.)-1766.5(Chinet)-366.6(T)72.9(,)-363.3(Collignon)-361.4(MA,)-366.3(Chretien)-366.3(J,)-364(Huchon)-366.7(GJ.)-360.5(Lung)]TJ
2.5165 -1.1192 TD
[(function)-330.2(declines)-336.3(in)-330.2(patients)-332.6(with)-328.5(pulmonary)-335.5(sarcoidosis)]TJ
0 -1.1128 TD
[(and)-421.9(increased)-429(respiratory)-426.4(permeability)-429.2(to)-425(99mT)66.2(cDTP)79.1(A.)]TJ
/F4 1 Tf
0 -1.1192 TD
[(Am)-334.6(Rev)-330.3(Respir)-333.8(Dis)]TJ
/F3 1 Tf
8.0933 0 TD
[(1990;)-328.6(141:)-335.5(445\261449.)]TJ
-10.6098 -1.1065 TD
[(9.)-1766.5(Chung)-248.8(KF)75(,)-249.5(Rogers)-250.2(DF)75(,)-249.5(Barnes)-250(PJ,)-248.3(Evans)-248.5(TW)80.4(.)-249.5(The)-248.3(role)-247.7(of)]TJ
2.5165 -1.1192 TD
[(increased)-321.5(airway)-319.3(microvascular)-318.4(permeability)-328(and)-314.4(plasma)]TJ
0 -1.1128 TD
[(exudation)-334.8(in)-330.2(asthma.)]TJ
/F4 1 Tf
8.7383 0 TD
[(Eur)-331.9(Respir)-333.8(J)]TJ
/F3 1 Tf
5.5073 0 TD
[(1990;)-334.9(3:)-330.2(329\261337.)]TJ
-16.762 -1.1128 TD
[(10.)-1266.5(Pedersen)-748.4(KE,)-754.8(Rigby)-750.7(PK,)-749.9(Goldie)-750.9(RG.)-749.7(Quantitative)]TJ
2.5165 -1.1128 TD
[(assessment)-477.5(of)-474.2(increased)-473.3(airway)-477.4(microvascular)-476.4(permea-)]TJ
0 -1.1192 TD
[(bility)-607.2(to)-602.1(125I-labelled)-608.8(plasma)-608.9(fibrinogen)-608.4(induced)-605.4(by)]TJ
0 -1.1128 TD
[(platelet)-276.7(activating)-275.6(factor)-279(and)-270.1(bradykinin.)]TJ
/F4 1 Tf
16.4332 0 TD
[(Br)-269.2(J)-277.5(Pharmacol)]TJ
/F3 1 Tf
-16.4332 -1.1192 TD
[(1991;)-334.9(104:)-329.1(128\261132.)]TJ
-2.5165 -1.1128 TD
[(1)25.8(1)0(.)-1292.3(Bonomo)-338.6(L,)-341(Daddabbo)-346.5(A.)-340.8(125albumin)-342.7(turnover)-341.4(and)-339.7(loss)]TJ
2.5165 -1.1128 TD
[(of)-480.5(protein)-488.8(into)-483.3(the)-487.5(sputum)-482.9(in)-481.9(chronic)-486.2(bronchitis.)]TJ
/F4 1 Tf
21.1122 0 TD
(Clin)Tj
-21.1122 -1.1192 TD
[(Chim)-337.2(Acta)]TJ
/F3 1 Tf
4.6347 0 TD
[(1964;)-334.9(10:)-329.7(214\261222.)]TJ
-7.1512 -1.1065 TD
[(12.)-1266.5(W)70.8(ard)-214.2(C,)-215.8(Duddridge)-216.8(M,)-211.7(Fenwick)-215.2(J,)]TJ
/F4 1 Tf
16.2752 0 TD
[(et)-216.1(al)]TJ
/F3 1 Tf
1.6945 0 TD
[(.)-217.9(Urea)-210.4(as)-214.9(a)-214.3(dilution)]TJ
-15.4532 -1.1192 TD
[(marker)-291.1(for)-291.3(the)-291.5(determination)-295.9(of)-284.5(the)-291.5(epithelial)-297(lining)-288.6(fluid)]TJ
0 -1.1128 TD
[(at)-254.1(bronchoalveolar)-263.7(lavage.)]TJ
/F4 1 Tf
10.7426 0 TD
[(Am)-258.7(Rev)-254.4(Respir)-257.9(Dis)]TJ
/F3 1 Tf
7.7835 0 TD
[(1992;)-252.8(146:)]TJ
-18.5261 -1.1192 TD
(444\261447.)Tj
-2.5165 -1.1128 TD
[(13.)-1266.5(W)70.8(ard)-245.8(C,)-241.1(Duddridge)-248.4(M,)-243.4(Fenwick)-246.8(J,)]TJ
/F4 1 Tf
16.4649 0 TD
[(et)-241.4(al)]TJ
/F3 1 Tf
1.7198 0 TD
[(.)-243.2(A)0(n)-248.9(evaluation)-248(of)]TJ
-15.6682 -1.1128 TD
[(albumin)-243.1(as)-246.6(a)-239.6(reference)-250.1(marker)-246.9(for)-240.7(bronchoalveolar)-251(lavage)]TJ
T*
[(fluid)-287.7(in)-292.2(asthmatic)-295.8(and)-289.1(control)-292.8(subjects.)]TJ
/F4 1 Tf
15.8262 0 TD
(Thorax)Tj
/F3 1 Tf
3.1615 0 TD
[(1993;)-290.7(48:)]TJ
-18.9877 -1.1192 TD
(518\261522.)Tj
-2.5165 -1.1128 TD
[(14.)-1266.5(W)70.8(ard)-416.5(C,)-424.4(Fenwick)-423.9(J,)-414.6(W)70.8(eddle)-423(A,)-423(Booth)-415.5(H,)-423(W)70.8(alters)-420.7(EH.)]TJ
2.5165 -1.1128 TD
[(Albumin)-373.1(is)-375.6(not)-373.9(suitable)-376.9(as)-373(a)-372.3(marker)-373.3(of)-373(bronchoalveolar)]TJ
0 -1.1192 TD
[(lavage)-371.7(\(BAL\))-377.6(dilution)-372.2(in)-374.4(interstitial)-379(lung)-373.4(disease)-373.6(\(ILD\).)]TJ
/F4 1 Tf
0 -1.1128 TD
[(Eur)-332(Respir)-333.8(J)]TJ
/F3 1 Tf
5.5073 0 TD
[(1997;)-334.9(10:)-329.6(2029\2612033.)]TJ
-8.0238 -1.1128 TD
[(15.)-1266.5(Kaplan)-356.3(JD,)-354.1(Calandrino)-359(FS,)-353.1(Schuster)-359(DP)106.6(.)-357(Effec)10.2(t)-356(o)0(f)-354(smo-)]TJ
2.5165 -1.1128 TD
[(king)-215.3(on)-214(pulmonary)-221.7(vascular)-214.8(permeability)51.3(.)-211.6(A)-217.8(positron)-217.8(emi-)]TJ
0 -1.1192 TD
[(ssion)-356.3(tomography)-354(study)62.2(.)]TJ
/F4 1 Tf
10.2494 0 TD
[(Am)-353.5(Rev)-355.6(Respir)-352.7(Dis)]TJ
/F3 1 Tf
8.1755 0 TD
[(1992;)-353.9(145:)]TJ
-18.425 -1.1128 TD
(712\261715.)Tj
-2.5165 -1.1128 TD
[(16.)-1266.5(Gil)-253.1(E,)-252.5(Chen)-255.4(B,)-253.7(Kleerup)-255.5(E,)-252.5(W)70.8(ebber)-257.2(M,)-249.7(T)60.2(ashkin)-253.2(DP)100.3(.)-249.5(Acute)]TJ
2.5165 -1.1128 TD
[(and)-327(chronic)-334.4(effects)-323.7(of)-335.1(marijuana)-331.1(smoking)-330.7(on)-334.1(pulmonary)]TJ
0 -1.1192 TD
[(alveolar)-336.1(permeability)57.7(.)]TJ
/F4 1 Tf
9.0165 0 TD
[(Life)-336.2(Sci)]TJ
/F3 1 Tf
3.408 0 TD
[(1995;)-334.9(56:)-329.7(2193\2612199.)]TJ
-14.941 -1.1128 TD
[(17.)-1266.5(Y)92(ates)-266.7(DH,)-267.7(Havill)-272.7(K,)-264.9(Thompson)-268(MM,)-268.8(Rittano)-273.6(AB,)-269.1(Chu)-268.8(J,)]TJ
2.5165 -1.1128 TD
[(Glanville)-564.2(AR.)-560(Sidestream)-558(smoke)-563(inhalation)-560.4(decreases)]TJ
0 -1.1192 TD
[(respiratory)-287.3(clearance)-281.9(of)-284.5(99mT)59.9(c-DTP)85(A)-281(acutely)56.4(.)]TJ
/F4 1 Tf
18.8423 0 TD
[(Aust)-283.2(NZ)-280.5(J)]TJ
-18.8423 -1.1128 TD
(Med)Tj
/F3 1 Tf
2.0929 0 TD
[(1996;)-334.9(26:)-329.6(513\261518.)]TJ
-4.6094 -1.1128 TD
[(18.)-1266.5(The)-792.1(BAL)-794(Cooperative)-800.8(Group)-792.1(Steering)-796.5(Committee.)]TJ
2.5165 -1.1128 TD
[(Bronchoalveolar)-420.1(lavage)-422.3(constituents)-416.3(in)-418.7(healthy)-418.1(individ-)]TJ
0 -1.1192 TD
[(uals,)-314(idiopathic)-313.8(pulmonary)-310.2(fibrosis)-314.8(and)-314.4(selected)-310.8(compar-)]TJ
0 -1.1128 TD
[(ison)-330.3(groups.)]TJ
/F4 1 Tf
5.2796 0 TD
[(Am)-334.6(Rev)-330.3(Respir)-340.1(Dis)]TJ
/F3 1 Tf
8.0933 0 TD
[(1990;)-328.6(141:)-335.5(S169\261201.)]TJ
-15.8895 -1.1128 TD
[(19.)-1266.5(Bridgeman)-308.4(MME,)-303.4(Marsden)-302.3(M,)-306.6(MacNee)-303.5(W)83.4(,)-306.4(Flenley)-302.8(DC,)]TJ
2.5165 -1.1192 TD
[(R)33.7(yle)-531.8(AP)106.6(.)-527.7(Cysteine)-530.9(and)-523.1(gluthathione)-527.8(concentrations)-532.4(in)]TJ
0 -1.1128 TD
[(plasma)-368.7(and)-365(bronchoalveolar)-364.8(lavage)-365.4(fluid)-369.9(after)-368(treatment)]TJ
T*
(with)Tj
/F4 1 Tf
2.0929 0 TD
0 Tw
(N)Tj
/F3 1 Tf
0.6639 0 TD
(-acetylcysteine.)Tj
/F4 1 Tf
6.5 0 TD
(Thorax)Tj
/F3 1 Tf
3.2057 0 TD
[(1991;)-334.9(46:)-336(39\26142.)]TJ
-14.979 -1.1128 TD
[(20.)-1266.5(Bell)-266.5(DY)120.9(,)-262.2(Haseman)-267.7(JA,)-265.6(Spock)-267.7(A,)-264.9(Mclennan)-263.9(G,)-271.3(Hook)-260.5(GE.)]TJ
2.5165 -1.1192 TD
[(Plasma)-493.7(proteins)-495.8(of)-486.8(the)-493.8(bronchoalveolar)-497.6(surface)-492.1(of)-493.1(the)]TJ
0 -1.1128 TD
[(lungs)-412(of)-410.9(smokers)-412.4(and)-415.6(nonsmokers.)]TJ
/F4 1 Tf
14.8272 0 TD
[(Am)-410.4(Rev)-412.5(Respir)-416(Dis)]TJ
/F3 1 Tf
-14.8272 -1.1192 TD
[(1981;)-334.9(124:)-329.1(72\26179.)]TJ
-2.5165 -1.1065 TD
[(21.)-1266.5(Rennard)-235.6(S,)-241.3(Basset)-239.9(G,)-239.6(Lecossier)-237.9(D,)-239.6(O)]TJ
/F7 1 Tf
17.1224 0 TD
(')Tj
/F3 1 Tf
0.2213 0 TD
[(Donnel)-236.3(K,)-239.6(Martin)-243.4(P)103.1(,)]TJ
-14.8272 -1.1192 TD
[(Crystal)-494.7(RG.)-496.8(Estimation)-497.6(of)-493.1(volume)-494.2(of)-493.1(epithelial)-493(lining)]TJ
0 -1.1128 TD
[(fluid)-528(recovered)-533.9(by)-523.8(lavage)-529.8(using)-532.2(urea)-529.6(as)-524.8(a)-530.4(marker)-531.4(of)]TJ
0 -1.1192 TD
(dilution.)Tj
/F4 1 Tf
3.6673 0 TD
[(J)-334.4(Appl)-332.6(Physiol)]TJ
/F3 1 Tf
6.2787 0 TD
[(1986;)-334.9(60:)-329.6(532\261538.)]TJ
-12.4625 -1.1128 TD
[(22.)-1266.5(Baz)-420.1(MA,)-423.2(T)60.2(apson)-422.1(VF)75(,)-426.5(Roggli)-423.7(VL,)-419.7(T)28.6(rigt)-421(PV)125.6(,)-426.5(Piantadosi)]TJ
2.5165 -1.1128 TD
[(CA.)-484.1(Glutathione)-487.3(depletion)-489(in)-481.9(epithelial)-486.7(lining)-491(fluid)-483.7(of)]TJ
ET
0 0 0 1 K
0 J 0 j 0.5 w 3.864 M []0 d
/GS3 gs
1 i 
220.705 652.663 m
245.478 671.102 l
271.587 672.82 l
215.267 660.663 m
241.188 672.5 l
266.149 670.258 l
117.346 667.061 m
141.346 676.983 l
166.947 675.382 l
111.165 717.297 m
136.368 700.972 l
161.509 742.258 l
166.947 711.859 m
141.021 714.251 l
116.277 681.271 l
161.189 751.539 m
136.228 720.499 l
110.947 670.258 l
S
BT
/F20 1 Tf
10 0 0 10 87.265 638.772 Tm
0 0 0 1 k
/GS4 gs
(0.0)Tj
0 4.1348 TD
(0.1)Tj
0 4.2587 TD
(0.2)Tj
0 4.1572 TD
(0.3)Tj
ET
/GS3 gs
102.707 768.073 m
102.707 642.065 l
102.947 767.881 m
100.206 767.881 l
102.947 726.232 m
100.206 726.232 l
102.947 683.903 m
100.206 683.903 l
102.947 642.182 m
100.206 642.182 l
110.485 635.69 m
173.35 635.69 l
110.812 635.899 m
110.812 633.158 l
136.925 635.899 m
136.925 633.158 l
162.668 635.899 m
162.668 633.158 l
S
BT
10 0 0 10 108.616 623.735 Tm
/GS4 gs
2.1426 Tc
[(12)8.6(3)]TJ
-4.0385 14.6906 TD
0 Tc
(a\))Tj
ET
/GS3 gs
206.707 768.073 m
206.707 641.27 l
206.947 767.881 m
204.205 767.881 l
206.947 742.433 m
204.205 742.433 l
206.947 717.097 m
204.205 717.097 l
206.947 691.507 m
204.205 691.507 l
206.947 666.258 m
204.205 666.258 l
206.947 641.522 m
204.205 641.522 l
214.485 635.69 m
277.35 635.69 l
214.811 635.899 m
214.811 633.158 l
240.924 635.899 m
240.924 633.158 l
266.668 635.899 m
266.668 633.158 l
S
BT
10 0 0 10 212.615 623.735 Tm
/GS4 gs
2.1426 Tc
[(12)8.6(3)]TJ
-2.0885 14.6906 TD
0 Tc
(b\))Tj
/F22 1 Tf
6 0 0 6 159.575 750.286 Tm
(n)Tj
ET
0 0 0 0 k
3.864 M 
/GS3 gs
139.021 716.251 4 -4 re
B
BT
6 0 0 6 133.901 718.286 Tm
0 0 0 1 k
/GS4 gs
(n)Tj
-4.2004 -8.4532 TD
(n)Tj
0.0501 -3.125 TD
(n)Tj
4.2004 1.2444 TD
(n)Tj
4.3815 0.2336 TD
(n)Tj
ET
0 0 0 0 k
/GS3 gs
114.277 683.271 4 -4 re
B
BT
6 0 0 6 212.282 697.654 Tm
0 0 0 1 k
/GS4 gs
(n)Tj
0 -4.3867 TD
(n)Tj
0 -2.1409 TD
(n)Tj
0 0.5103 TD
(n)Tj
4.3006 6.0009 TD
(n)Tj
0 2.0897 TD
(n)Tj
0 -4.5232 TD
(n)Tj
0 -2.0576 TD
(n)Tj
4.3315 11.2799 TD
(n)Tj
0 -3.3726 TD
(n)Tj
0 -4.4368 TD
(n)Tj
0 -3.9878 TD
(n)Tj
ET
0 0 0 0 k
/GS3 gs
269.883 674.375 4 -4 re
B
243.478 673.102 4 -4 re
B
218.577 654.198 4 -4 re
B
BT
/F20 1 Tf
10 0 0 10 127.102 613.735 Tm
0 0 0 1 k
/GS4 gs
[(Aliquot)-8093(Aliquot)]TJ
0 10 -10 0 79.936 675.503 Tm
(Urea )Tj
/F17 1 Tf
2.005 0 TD
(m)Tj
/F20 1 Tf
0.576 0 TD
(mol\341mL)Tj
0 8 -8 0 77.102 728.192 Tm
(-1)Tj
/F22 1 Tf
6 0 0 6 159.575 740.685 Tm
(n)Tj
-4.279 -6.9326 TD
(n)Tj
-4.2004 2.7208 TD
(n)Tj
ET
0 0 0 0 k
/GS3 gs
165.583 677.212 4 -4 re
B
139.661 678.493 4 -4 re
B
114.701 668.892 4 -4 re
B
165.583 713.689 4 -4 re
B
3.864 M 
112.548 651.062 m
136.548 657.781 l
161.509 659.702 l
266.541 740.172 m
240.868 712.82 l
214.627 700.342 l
266.541 719.936 m
241.508 699.702 l
214.627 664.18 l
266.469 692.983 m
240.552 684.838 l
215.267 673.46 l
S
BT
/F3 1 Tf
7.97 0 0 7.97 58.28 598.564 Tm
0 g
/GS2 gs
[(Fig.)-327.1(2.)-331.2(\261)-332.2(Biochemicall)7.7(y)-503(measured)-501(concentration)9.8(s)-504.1(o)0(f)-508.1(urea)-501.9(assayed)-503.9(in)]TJ
0 -1.067 TD
[(three)-402.6(60-mL)-398.1(bronchoalv)13.4(eolar)-402.6(lavage)-399.3(\(BAL\))-405.2(aspirates)-397.9(in:)-403.9(a\))-407.5(five)-398.6(non-)]TJ
0 -1.0599 TD
[(smoking;)-316.6(and)-319.9(b\))-323.2(five)-320.4(smoking)-316.4(normal)-316.4(healthy)-322.4(subjects.)-314.5(The)-322.6(results)-318.8(for)]TJ
T*
[(each)-394(individua)12.8(l)-398.6(aspirate)-391.7(are)-397.3(shown.)]TJ
/F15 1 Tf
14.8878 0 TD
(u)Tj
/F3 1 Tf
0.8322 0 TD
[(:)-398.6(grass)-389.4(pollen-sens)10.7(itive)-394(\(atopic\))]TJ
-15.72 -1.067 TD
(individuals.)Tj
8.966 0 0 8.966 523.049 797.499 Tm
(289)Tj
7.472 0 0 7.472 224.334 797.499 Tm
0.0001 Tc
[(UREA)-343.9(IN)-333.2(BAL)-333.6(FROM)-342.7(HEAL)79.7(THY)-334.7(SMOKERS)]TJ
ET
endstream
endobj
37 0 obj
<<
/ProcSet [/PDF /Text ]
/Font <<
/F3 6 0 R
/F4 7 0 R
/F6 9 0 R
/F7 10 0 R
/F15 29 0 R
/F17 30 0 R
/F20 31 0 R
/F22 32 0 R
>>
/ExtGState <<
/GS2 13 0 R
/GS3 33 0 R
/GS4 34 0 R
>>
>>
endobj
39 0 obj
<<
/Length 5586
>>
stream
BT
/F3 1 Tf
8.966 0 0 8.966 80.844 772.157 Tm
0 g
/GS2 gs
0 Tc
[(lung)-272.2(allograft)-275.9(patients.)]TJ
/F4 1 Tf
9.2441 0 TD
[(Am)-277.7(J)-271.2(Respir)-276.9(Crit)-280.5(Car)33.6(e)-277.5(Med)]TJ
/F3 1 Tf
11.3054 0 TD
(1996;)Tj
-20.5495 -1.1128 TD
[(153:)-329.1(742\261746.)]TJ
-2.5165 -1.1128 TD
[(23.)-1266.5(Thompson)-502(AB,)-509.4(Mueller)-508.2(MB,)-506.8(Heires)-503.8(AJ,)]TJ
/F4 1 Tf
20.2902 0 TD
[(et)-507(al)]TJ
/F3 1 Tf
1.9854 0 TD
[(.)-508.8(Aero-)]TJ
-19.7591 -1.1065 TD
[(solized)-375(beclomethasone)-372.6(in)-374.4(chronic)-378.7(bronchitis:)-372.6(improved)]TJ
0 -1.1128 TD
[(pulmonary)-221.7(function)-229.1(and)-219.6(diminished)-226.2(airway)-224.4(inflammation.)]TJ
/F4 1 Tf
T*
[(Am)-328.2(Rev)-336.6(Respir)-333.8(Dis)]TJ
/F3 1 Tf
8.087 0 TD
[(1992;)-334.9(146:)-335.5(389\261395.)]TJ
-10.6035 -1.1065 TD
[(24.)-1266.5(Schuler)-345.7(P)109.4(,)-344.4(Zemper)-350.6(K,)-340.8(Borner)-344.8(K,)-347.1(Koeppe)-347.5(P)109.4(,)-344.4(Schaberg)-336.2(T)72.9(,)]TJ
2.5165 -1.1128 TD
[(Lode)-481.8(H.)-479.9(Penetration)-487.3(of)-486.8(sparfloxacin)-488(and)-478.8(ciprofloxacin)]TJ
T*
[(into)-597.1(alveolar)-601.6(macrophages)-604.5(epithelial)-600.5(lining)-604.8(fluid)-597.6(and)]TJ
T*
[(polymorphonuclear)-416.5(leukocytes.)]TJ
/F4 1 Tf
13.0947 0 TD
[(Eur)-414.1(Respir)-422.3(J)]TJ
/F3 1 Tf
5.7602 0 TD
[(1997;)-423.5(10:)]TJ
-18.8549 -1.1065 TD
[(1)32.1(130\2611)34.2(136.)]TJ
-2.5165 -1.1128 TD
[(25.)-1266.5(Marcy)-270.5(TW)80.4(,)-274.8(Merril)-276(WW)84.7(,)-274.8(Rankin)-275.7(JA,)-271.9(Reynolds)-275.9(HY)120.9(.)-274.8(Limi-)]TJ
2.5165 -1.1128 TD
[(tations)-276.4(of)-284.5(using)-279.2(urea)-276.7(to)-279.6(quantify)-286(epithelial)-284.3(lining)-276(fluid)-281.4(re-)]TJ
T*
[(covered)-376.1(by)-384.7(bronchoalveolar)-377.5(lavage.)]TJ
/F4 1 Tf
14.9221 0 TD
[(Am)-378.8(Rev)-380.9(Respir)-378(Dis)]TJ
/F3 1 Tf
-14.9221 -1.1065 TD
[(1987;)-328.6(135:)-335.5(1276\2611280.)]TJ
-2.5165 -1.1128 TD
[(26.)-1266.5(W)77.1(ard)-214.2(C,)-215.8(Duddridge)-216.8(M,)-218.1(Fenwick)-215.2(J,)]TJ
/F4 1 Tf
16.2752 0 TD
[(et)-216.1(al)]TJ
/F3 1 Tf
1.6945 0 TD
[(.)-211.6(Urea)-216.8(as)-214.9(a)-214.3(dilution)]TJ
-15.4532 -1.1128 TD
[(marker)-291.1(for)-291.3(the)-285.2(determination)-295.9(of)-290.8(the)-291.5(epithelial)-290.7(lining)-295(fluid)]TJ
T*
[(at)-254.1(bronchoalveolar)-257.4(lavage.)]TJ
/F4 1 Tf
10.7426 0 TD
[(Am)-252.4(Rev)-254.4(Respir)-257.9(Dis)]TJ
/F3 1 Tf
7.7772 0 TD
[(1992;)-259.1(146:)]TJ
-18.5198 -1.1065 TD
(444\261447.)Tj
-2.5165 -1.1128 TD
[(27.)-1266.5(Ef)15.5(fros)-216.1(RM,)-215.9(Feng)-217.6(HN,)-217.1(Mason)-214.1(G,)-214.3(Sietsema)-216.6(K,)-214.4(Silverman)-216.1(P)103.1(,)]TJ
30.5144 21.1122 TD
[(Hukkanen)-277(J.)-275.5(Solute)-278.3(concentrations)-279.5(of)-271.8(the)-278.9(pulmonary)-278.6(epi-)]TJ
0 -1.1128 TD
[(thelial)-334.3(linking)-332.4(fluid)-332(in)-330.2(anaesthetized)-335.5(rats.)]TJ
/F4 1 Tf
16.8758 0 TD
[(J)-334.4(Appl)-332.6(Physiol)]TJ
/F3 1 Tf
-16.8758 -1.1128 TD
[(1990;)-334.9(68:)-329.6(225\261281.)]TJ
-2.5165 -1.1065 TD
[(28.)-1266.5(Burke)-376(WMJ,)-381.9(Roberts)-378.5(CM,)-380.3(Bryant)-377.8(DH,)]TJ
/F4 1 Tf
18.9371 0 TD
[(et)-380.5(al)]TJ
/F3 1 Tf
1.8526 0 TD
[(.)-382.3(Smoking-)]TJ
-18.2732 -1.1128 TD
[(induced)-422(changes)-426.9(in)-425(epithelial)-429.8(linking)-427.2(fluid)-426.8(volume)-424.6(cell)]TJ
T*
[(density)-337.3(and)-333.4(protein.)]TJ
/F4 1 Tf
8.3526 0 TD
[(Eur)-332(Respir)-333.8(J)]TJ
/F3 1 Tf
5.5073 0 TD
[(1992;)-334.9(5:)-330.2(780\261784.)]TJ
-16.3763 -1.1065 TD
[(29.)-1266.5(Baughman)-457.3(RP)105.2(,)-451.8(Bosken)-457.9(CH,)-452.5(Loudon)-455.7(RG,)-452.5(Hurtubise)-460.7(P)103.1(,)]TJ
2.5165 -1.1128 TD
[(W)70.8(esseler)-589.5(T)72.9(.)-590.9(Quantification)-596.4(of)-588(bronchoalveolar)-598.8(lavage)]TJ
T*
[(with)-246.3(methylene)-241.6(blue.)]TJ
/F4 1 Tf
8.5675 0 TD
[(Am)-239.7(Rev)-248.1(Respir)-238.9(Dis)]TJ
/F3 1 Tf
7.7266 0 TD
[(1983;)-240.1(128:)-246.9(266\261)]TJ
-16.2941 -1.1128 TD
(270.)Tj
-2.5165 -1.1065 TD
[(30.)-1266.5(Kelly)-397.3(CA,)-401.9(Fenwick)-398.6(JD,)-398.4(Corris)-399.2(P)84.1(A)0(,)-397.7(Fleetwood)-399.9(A,)-397.7(Hen-)]TJ
2.5165 -1.1128 TD
[(drick)-398.9(DJ,)-404.7(W)70.8(alters)-401.8(EH.)-400.7(Fluid)-399.2(dynamics)-405.6(during)-398.6(broncho-)]TJ
T*
[(alveolar)-336.1(lavage.)]TJ
/F4 1 Tf
6.677 0 TD
[(Am)-328.3(Rev)-336.6(Respir)-333.8(Dis)]TJ
/F3 1 Tf
8.087 0 TD
[(1988;)-334.9(138:)-335.5(81\26184.)]TJ
-17.2805 -1.1128 TD
[(31.)-1266.5(Restrick)-228.4(LJ,)-227.9(Sampson)-225.5(AP)100.3(,)-224.2(Piper)-226.8(PJ,)-223(Cortello)-229.8(JF)70.8(.)-224.2(Insulin)-231(as)]TJ
2.5165 -1.1065 TD
[(a)-391.3(marker)-398.6(of)-398.3(dilution)-397.5(of)-392(bronchoalveolar)-402.8(lavage)-397(in)-393.4(asth-)]TJ
0 -1.1128 TD
[(matic)-370.4(and)-365(normal)-368.7(subjects.)]TJ
/F4 1 Tf
11.3307 0 TD
[(Am)-366.2(J)-366(Respir)-371.7(Crit)-369(Car)33.6(e)-372.3(Med)]TJ
/F3 1 Tf
-11.3307 -1.1128 TD
[(1995;)-334.9(151:)-329.1(121)26.8(1\2611217.)]TJ
-2.5165 -1.1128 TD
[(32.)-1266.5(Haslam)-511.1(PL,)-509.8(Baughman)-507.9(RP)-508.1(\(Co-ordinators\).)-516.3(ERS)-511.1(task)]TJ
2.5165 -1.1065 TD
[(force)-359.3(on)-359.4(measurement)-362.2(of)-360.4(acellular)-363(components)-360.3(in)-361.8(BAL.)]TJ
/F4 1 Tf
0 -1.1128 TD
[(Eur)-332(Respir)-333.8(Rev)]TJ
/F3 1 Tf
6.5505 0 TD
[(1999;)-334.9(9:)-330.2(1\2616.)]TJ
-37.0649 23.9385 TD
(290)Tj
7.472 0 0 7.472 269.121 797.499 Tm
0.0001 Tc
[(C.)-335.8(W)102.5(ARD)-333.4(ET)-263.8(AL.)]TJ
ET
endstream
endobj
40 0 obj
<<
/ProcSet [/PDF /Text ]
/Font <<
/F3 6 0 R
/F4 7 0 R
>>
/ExtGState <<
/GS2 13 0 R
>>
>>
endobj
41 0 obj
<<
/Type /Halftone
/HalftoneType 1
/HalftoneName (Default)
/Frequency 75
/Angle 45
/SpotFunction /Round
>>
endobj
42 0 obj
<<
/Type /Halftone
/HalftoneType 1
/HalftoneName (Default)
/Frequency 75
/Angle 45
/SpotFunction /Round
>>
endobj
13 0 obj
<<
/Type /ExtGState
/SA false
/OP false
/BG /Identity
/UCR /Identity
/HT 41 0 R
>>
endobj
33 0 obj
<<
/Type /ExtGState
/SA true
/OP false
/BG /Identity
/UCR /Identity
/HT 42 0 R
>>
endobj
34 0 obj
<<
/Type /ExtGState
/SA true
/OP true
/BG /Identity
/UCR /Identity
/HT 42 0 R
>>
endobj
43 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [-169 -227 1003 776]
/FontName /PHGHBG+AdvP6EC5
/ItalicAngle 0
/StemV 0
/CharSet (/C101/C111/C121/C102/C112/C103/C104/C114/C105/C115/C66/C116/C97/C107/C117/C98/C108/C118/C99/C109/C100/C110)
/FontFile3 44 0 R
>>
endobj
44 0 obj
<<
/Filter /FlateDecode
/Length 1362
/Subtype /Type1C
>>
stream
H�dS	LTW�7��M������\ �a��E+�A�"��DYQ#���(.(TY�QbT�T[��"�U�[k������
.MӼ��{_�}����#�TB�Շ���N���^����	�F*j>����j��~�l!j,lW����%��06c�q�8N�<�]������9s��L�Qkt
�'�ړ�j/
ojS�}���j�����
���ߏ�?��?5-PSW����0��x�4&S�K�rRAv��d�F�����2RI�H5�O�H	�Nv��d�C{ګD&��tI^��G������5�"i����V�V�V-V�e�,R�/;(�i.P��A;�f����v��d��n�������Mզ�ʁ8�b��0����B�…����i����W2b�:r��������q����=:�!Af�~̓�m.���W��T�_��0�H��9�熹�\�(�����;�巯*�\�i
��y��{�(��>�Ex��5���L�{�W�ʺʽ������3�j<S����{��)З�|1�C��	�x���8~9ۤ�^��]��&~��,�`�9q�kCC&@n�{�����6�<��Y؀|��
Âp,���C,,���;�xv$���
{<+��F�6.G�^��t���P��ن�nz���G�:�S���
O�+@�%$f'�����m� ��,l��]����0�!0����0�$��\EKG�����
A�^�-�p��������a�s�	���(V�t�a
'�B��@��%/�4��z�����:���̓kSR�
����"Sֱ UA�N�x,�F���ZlM��ov��	^��~��W�������]>�HZ���bt�N`b=�q�a��$-<0�'J��Nb��et�v�D��!�3��G��@ ��0zH`0���cď�\i��GGoqY��8r�]ym�>#��NI�f��#)25W0�D���`M����������ɯ>��ޒ��ٿM�&F����3�׃xr��t����(��\���C���B�=P���'}}5O@��P^
1���[�F���]90�C�����Z
����-���W�IK�3,�u�����j���.1T��,7Uڴ�ѫ�o���Dd9�V��G\T��m��K��UOev^��+��iʑE�2�O�1�;0�
> �-V��j�JYY�[�9�g��$��5d�����[[k4�
/�ś6�"�����ܛN��>0M�a��g,[�t�m�P���/.5w�K�`�f�%v*՚ف1�(T����Ȁ�%��%`
��M�6 ���oH���Xh4nP&/��/>�Ł#�K��	b
��FP�[
endstream
endobj
45 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [-165 -224 1000 775]
/FontName /PHGHBI+AdvP6EC0
/ItalicAngle 0
/StemV 0
/CharSet (/C101/C111/C121/C42/C52/C72/C82/C102/C112/C53/C73/C83/C103/C44/C54/C74/C84/C104/C114/C45/C65/C75/C85/C105/C115/C46/C56/C66/C76/C106/C116/C57/C67/C177/C87/C97/C117/C48/C58/C78/C98/C108/C118/C49/C59/C69/\
C99/C109/C40/C50/C119/C70/C80/C100/C110/C41/C51/C120/C71)
/FontFile3 46 0 R
>>
endobj
46 0 obj
<<
/Filter /FlateDecode
/Length 3228
/Subtype /Type1C
>>
stream
H�tTkTSW�	�70(�RMj� L�b.IH��9RD** �UGE'�:�QA�c�B}�J��yD
u������'�#*�0��;�̍]��k~����w�����l"�I%���)�q�Q	
������:'�
�R!��-h�e������a�S�M���R�%	'�r7~���)>~��qShDTL|brjzƢl�;�W��ֽ�i�֢��/�8Xu�������s�����9N�`�7��`�̛�E\4N��Iϛ�"��
�h�M�l��q�`�C���ț�"&g�
!�1�	�M!"&'&>��s&o6�qřx��7�y����E�h��7Xx������Yx��7�D��7�x���9w:���Fg�:����`�|C(��f�Y�y�$E���$��O���:��LΓ��r�'��+�Nv�=d?9B��	r�T�*�i ����"{�Ǥ�|FN����|D�ȧ��%�H#i#E���#�� ���&M��Nv��9J�$u��t�bR#	�+�I8I��I��FR/"2� ��J��k�}.A.�.�.�.wdSe�tY��[�+�@�R��.�>K/����z�zy��߮Ѯy��]q�w�t��V��H�HRU|�ܽ�g���w����`�}
�JƩ��9Wq��i��ÀK�q`Q����A����H �2�@�
���_�iR���]B%ZT�u~`�ܮz��]?�mY�`����@rb݅��H�T>��Rf���Agf�i2�J�W�Z��W.���,栘Vf��Q����f�?����j3G!�[F��[|0Z3�
�%��0k	�@-j�q9dAV=,�F	h���ҫQ���\c��(�+a��6�V���d��S�s��[5s14oZZŒm��,��sxѻ�_x��ÙI#�u��
^}���f��bp�2�v���^�"tv��n���vVG�
=�gu}�D�v5��)���;–���ڛ~V�+�_ä����v��'LP�|��Oȋ۸a׮��R8�L���(J�����0�!D�9�eJ��J��2p~�!���z����-��W�x-M�O�҅'���E,�JP,}������G��H�^\`[)��)�3��͡j|'�b��2cc;�\��S���h�i�l���*G�c��������f
$���Df�����^��! ǍI��L~Ywni�B�p����u��Q	'v�4�Vf�U�vF�H�,�xss�Bo�*�:���ak+��V�=Mcn_�	Di�-���_�n�~���aS����{��I�,�d�P
�3�׏ueK�)�C���5����6VO�5�;X`[9�p�|xm�������
�)�gRL������ᆘ0d�2���P(�������Č�����@.�=�R�4�ۭJi��R��[�K`@רz�Q""�D� iȍק�b����|C������4_t��?]y�U�$��4x�rLd`.���:m���Z�(��)�a	9&�1�p��0LS'�A�v�aˑ�����9�
3୑��}mĆ^լ�
�
�[�)�)�'D8�Y�jQn��������p|8f3/&C'6:bC��MN�[EK�8w!��RF��?�'Բ�4��T�q�f Y�� �e����O�������UAԷ�+x�y)�E�0w8�/悇�;>�[��3"�ne�_V|%l`����†@��᰿�Z�vo�Мs�f�(Qk��A��]�Lh�&
U4�0�ΐ"w֯х��r���Fz)��Y��Z �^
��:�vFOt�3����*��
��h�
h�]���
�d{~}�)��x�ײؔ�R$�Yp��WVn�dǙ�{R�3��Jז���Q��
|�<o���6��-��3s}4���
�!a�_��q���P�2�0�����חQ�X}��3U~�X3ݧN����/�s9M����%�<On��c.a1���ٿ��e�畗�<z]��ï�݃��1�!�
8n�|����Y�1Q\QT�yC����m��3`�k�."��[X�)�Pl��V�D�"F.� ����K,h��B���Ԇbe-�~����c���.��6��y�f��y�{�#��T��־b8GSBY����G�0��HyH�u����<��lR
vF����`��zş�V���@�';-��0��6��;��L�+W����͉�9�rm2�q��h�.�&���Z�̲�uwEg]EY��������yU
2|Ƀ
�(���o���B�6%-^�����zݹ
	�:9j�| @�k�mKy ��N_�ECY�-I�Y��e��ϵL����!���6��w�l�	�*Qx�(��3�����8[���Q�Pԏ�4���K�5\%�2Ӯ��x����c����dDאI�F�g�B�����d�C�N������8#�-�L}�@\�
f�L�E9$+A�><��b��O]&���5����H���"��z��	���e'���da�gp���7é�V�W��[�^���ؙGII��-_�;�4_\��!/�D�T�\J5ы�����"m�n�����\n��ǖ�+Ð~`��H�
�_�PT
���Pl	_dMޘ#��(��g�4p��=g�	t�>�0Oq
F��b�c�q��i�>��/J�v������VM���货Q�b���SR��^�d�9��/z�$Y%|삛|������T���.x̃.�)!|Cv�U�p��������vȶ�0����(H���y�1m�����4�(�F0��6���Є&3�(�j�ɾ���5��[QCv�4���9�WxV�Oe)-R�8�,���M����!3~s���hbv�;{��ZF�����@\��6v�lqCv����L�A¸W��[>Ϻ�'M�p�;�vghW�ʉ����u�BYLY=M�L�?�)7ַ��S���[v���s��;U���6qc�[`�n�-� #-�����1�֌T�,�7K����6�a��Qvk�;x��`�Xem�/��Q����X��{�?��&�k�L:�@��n󞥼�2HP�͢5���O:�J0��oj07��@a#P��*�`4���Z�@O�G�ׇ�� @4Tr8��7Ơ7�p�1�`%�8�`T��`
��gN�	��A��Bg3����my�d_�.������a�����*��h�)]�'�]QJ�/�w���L��
endstream
endobj
47 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [-76 -215 1008 717]
/FontName /PHGHBK+AdvTT5843c571
/ItalicAngle 0
/StemV 0
/CharSet (/C101/C111/C42/C121/C52/C72/C82/C90/C102/C112/C122/C53/C73/C83/C93/C103/C113/C44/C54/C139/C74/C84/C34/C104/C114/C45/C55/C65/C75/C85/C105/C115/C46/C56/C66/C76/C86/C106/C116/C47/C57/C67/C77/C87/C97/C107/\
C117/C48/C58/C68/C78/C177/C98/C108/C118/C49/C59/C69/C79/C89/C99/C109/C119/C50/C40/C70/C80/C37/C100/C110/C120/C51/C41/C71/C81/C91)
/FontFile3 48 0 R
>>
endobj
48 0 obj
<<
/Filter /FlateDecode
/Length 9672
/Subtype /Type1C
>>
stream
H�TTip��>���0�ܰbv	G�i-[�$�%_��`0C�0�1��-[�,�\�.�ѹZݲlɲlc���(���b'!��v��错2i4�iG2J:]��?��������}�g��B�?�k箷+���^KU�X**�K����]��]R�-w�y�taV_��-�s�g͛c+�>N
�"�����k�Z�
lo��!
)�9��;�n����p��@58.�z 
�m@(`
v�	��| "  ��e0��upL�{`
̀`<�_�����	x
��
��Y���/!a�	�B$*C�2!�!I��!Y)W�8a�/C�r$)G�r$+�x�r$!�	�eH"BR*�nJ9EH$Fb1�#�I��A(F�
$�@HR���AX�D$��
	�H�T�d��A(A")KQ�I�H�Ueܥ��P�D2$��
��2$�!���prt)�"I)����|/n!��R$�"�I�H&���p�:�lZ��e�K�.8
N���������a;�n�����C8?���C���xޅ	8��_�{�c���I8G�M8	�/��`���p~�𷐅��6����]��`
������a�a��������ax�y�
@=���D~���U�nv�*R��zysXz�/�/޳��K�%[���|��/S,���r�����W�W�V���_�������U����ՋV��E8���O֜\�Ob'��L�=�jɫ
����~Cb��O_��^�m����wo~��rK�Mn~����~:���s�9���ր�%X���	�+e"M�M��M���4��˭+���v�t�2
���� y!2��y�V�뜍L5ї��I�fk��e��U?T�(ʶ�Wq��%�
Z�$:�R߀��-u��s��`h����0]Oœ���d�`��}���Z�b��|�IA'����?�3���L�5̈́ڨ�5���XHk
Yc����x��DW0�F9mV�{�W(̜
�
�3�Hb���`�rx M�B7��!�!M���nE)���%/�My�̩w�����
���
4z&b$�	��i|�{=� ���/�i���|�;¿�hL�zU����ϐ6~@���S��/�Y���"0�u'5����y?�ݳ��;*m��k����T%�[9Ru���W�'��/߸g^�R�5Ǜ�My�1��eNb�A����>�A�p����F^s��Z��y_���L�	�����C�gM��|����/��?֋���f,Y�կ����qm��ż���Vm3�I���4�����{��t��m�ѭ�ʢ�ՙUV�Mg�h�	3��R.�14��>���#�h4�
GC�`��]�N��V�Y��J{��:�^A�~[@��\>�d�?��,)�a�Ż�.�
i��am���~;+`'Ð^��a�9`�V�{�ir�x5���ۓ�\����,Ʋgm��!�����h�Y��Ѣ�(�tm����q'})�I���x��}ܸ��(��&i�M��
ne�"�(]
��V��^n+"z%�Lc����0>`J�u��V�E��Z��`�p�6��54�F���!=
��%p8;����Xp9լ�����7<?�s�����Q��Y�tmf�7|��BQ���굸֭�S��\�P���In�`�[\���Q���)�X���s���e��G��H�+~Yt��>b���gg�C��09����z&s�3P���sć�'R�
�.U�dMc��aLQe�����7=�5�&��ȵd���A,b�BdL�E�e�n�7�o�T�Vު�4�js��lC�TL�χ�8�%�펺�0v+���vP�S��+<��Wݮ�ӄ���M6�J��uu��]ju�)�r��v��:W�씆����?���J�IK���6Xt�]��qN��^�ML>~2936�������a���j�01\{2vX��i���������~,V�J��XW����Sd�1x�4~���㻉㻷���j�mۼ��K�C��VEBb$�m����/E�X��@נA�8���I,˲,˖LS%Q�DݝX��B]��lE��K9GK��N�d	�-�"���lT@�/;-�,h��sx>~�;�9|K�Z��*�Z���VQr�v�|�X�RY<��N�"����0˔�@���`J��E'[�֌��D�06�(�$�y�$0bRmQ�����v�9@E��%����V8���A�!�%	5��8��o�o]���7>C֬5���*cyYlݼ�qY���JXM=��AR��IrD�-��+�G�:�-�v�v|�/
��~E)��
�$�M�����z�k��ݞ�n�3��K%%(�će��4�Qcj�(#G	2�"q:
�Bw��[��;��a��f̒^p���+��
^�R�l6�.r�UB�%dk�9�����a�������}�տ�6���oKF�vF������9����
d����7���ƫ+�:z�V��K��zjc�m�6Z��ʡ��h?���c
n5]MUs�r�T*g��r|)���Z�p[��d>��r
���qt������`��9m�O��ԤY���`�ƵY�eX�Z)�.����J8W����'�%�2�	�w�t����_t�	|��.�o��(A5��6��s��1lh��.z�jr��׫�kHݼD�0}Q�t��Y�_L�@�.��qQ��-�=h�9zlW���RD�$	,A�F�R��/����	sҞ:`K�Si��e�N͖��K�>��QBٖ/Ka,5����Hu];�W��>��"+��0J�aGP�:V��ڢ�v�X���x)S,�����Yr�v����]�٬���s?G��6��Й|7z�W�-Õg�S���dM�)�W�K�8sB۫�S�)Fz�W�X)j���7�'�!
,�v��à*�������C�fd5W�J9(&��g�����D��1��(�Rl�/�x��Z�5��F��F��h�����e�YV���
{���iϞڒJL/-�@�\��=O��xw���k��߳z��W����,�}a��>_=������$>�2��e�90�np灁���]�ę��CC�[��E�s��ӫh�
���иa�<-Vyu>6ؐ;�?+a�����DL]"P"^�g�}B�=������F��d2%�)E+5d�\#*Q���@ht�׃
����8gg�x��'����r7��댲k�I_���
���V@��]��UL�U&�D��PY���҂��n]e&�xU��#�CMڬ3�$XR��G��3&��1{-���G���84��f��ɠWW�g��$	d���0v��	:<��{����n�i�ہ�i��P�m6�����X?z�=ދ����O��.��G�;�#�DZw����?F����x��z��e�엝T��~Tn����Fr\^P/��jؚ[ȟ#ۙX��|�����Xm���W�����@Bd�v����
�����7������jb���ʩ<����
r���ODp
;�IZ[��򢿂~yw�g��)yys������1���w���B�vH�y��Ó�2Ç)������c'hȋ��9��X?!Ev�U�Sns�;�v��Q������Ћ���8EѴ��]�e�����>��<�s���?���t���Aq9�vr8���ͯ�@��
�i9;A3�b�t���<'j������JngO:9k���"��8H����+�L��q>;�Y�S�6M27�`1�L9& X~9M�hS���<]B����~�U�Kz�1<��
����H��Dn�m�l��(�*���E{s����OZ�t;����24��qM��
���G�&Mީ<�{��@��tu"�>�8��s��2�u�q���^N�dN�4[ưd8.��9!���<.ha�<�����R!�I�e�6�jI�Je�ܿ�
�d���]����M�A�^�+t{����e"7�y�s�I[�$Uo��|�`(�!��%�BZ�C>����Yo���?�g�m�X�"�0��]��9��^�k7����	�"��Ⅾ�B�	a{��o9-yIm��5�讶�6�,�E�3oHEf�1#
/\�QAiw[��m�Ҳi����&Nb;���Ԟ������x<�/�%qnN����n�[Z({�@*��+^V��J�h���vڲ���9�9�9���S��,f�r��E�=���;	Z��h���Z�!��p�'�Y'��$I&�WH�W9��1�k�7_�	I2�q�#��*r]��e��ϔ3pb�[���_�I3�O��\��k=��_����d.�d!ʼn��&'�)�JAr"D���R��$}�p_G���w��4
���f��4�h�P�*�܆�~(��j��FHuj����Л"�E"d�"i�&�!�
��@��ޒ�H�S]�ZHe�Z|�'u��ud���q:}x���
�����8�h��2<La��Զ@KE.�E!.
x�"��*�%W
�D�oa�A��8���n�iN��m��|����t������KP�M?��$�Lq��#^�҉l|�1}z�d=�Q��N�p��%�bk9;܏�w��
֡5Њ����[��S�H᐀g�%P)y�v�~�N���=���z�g����i�R����dsf�`EJ�+�q��]H}#T�F봝�r��
pԖW��ރ�������3/^ۍ�q�+�?п=w�s����o�G�i����E��s/��1\���Y������C��u���=���C�����Omߪ?C���y�
v�z>m����!�2�0V�Q��<_�敳W�%b�6�Y�-9���C�L�mO��3͎ҷ;:���A��3ւ�tQ��T~P���R.�F����9Bv�VX�r��غ�|&�O�M�p�g�ݰ
T�)�_r���~��l�Ϸ��ͷ@�7v�T����]��ݻ�/=��'��?��V�-���E�yלy��j�j��%�����p
:�v����r�i�'����é�c�8�}��pa���+��m��b����D;�=
o
�
�߬^�NW��Z(^[{Q1�D��v�.
TN��U�i�X\ɕ*p�"-� ��Y�f��dL,��v�}�$܃�����
��Xk�H��h4:Ƣ�46.�]��S3���������,zz�7X�K�I�Q䰻�<�Y�}�!f�	��V�k�M����@�i*L�$��.<�u<ދ�s�e��{���7$�1і.8��O��ɀ��q7���H1d�cv��߅��cr?�'�3ނ�@,�`�6��'Rl<��l,£|6�VП���J8�O�.�K�왋H�*�(��vŦ)�9���s�"앩L)%
���O%���4�§�9Gj05���:�9i��ة�����<^�'EET$1��l2�Ao�#�{�y��e�|���@��WpqD���
02϶x�D�S��r��я��lV#�����Qc?'�p��JB	��988��uZ�"bi1X��4}{Aix����B��5�/a�R�K�SVغx��W�ƥdq	?U*�H�p���%��*p$����R#��HM\�(�@�L�HXD
�Cz�1�����+�6�g�*Ɉ���<�e�3,���ʆeF�EZ���SqW�_�٦�Uw�jr6UT�M���QXiF��׆�Of�#���0KE��)���6�7h�u�g��N#I6���K��*��p��h���P��i���,��'�;۲{��?j?��:�2U�@�|<	�-��+)�e1�%���Q�@}�-�W��mU��o�e��ZE:#�c⦸,�	����O�
��t2���8��T#@�9�0�����F���ϋ��	I��
K�j�!��bx�H�y�'��Y}C��i��/nv����̩/C��j4;#OJҦ��d��$ˣI�!
��׫�����2/�h���VQ�W_�V���U�B��k#�����v�&�������\{@�4ei[�ckK�cK��U��[]�hP7���m�V�k?jf��Mu�s�@�)�1<I���B�B/C��$��!&8D��8��L$̅8,��� �3Й�4-a��Wv
pr�;��w��Y�~�wȂx"Ob
^`DTX��y�S��N⒢�	����r.�7�H�D'2m�쳚&������q��`�c�٢�dؘ�'���j��샦.�ۊ:�1��������
ߴ������"X	��]-,� T��*�t��6M�~$N�8���������c�=�c�=v\�I�4M����K���BBH\s�����'�ѕ�
s�y��<�9�d+�z�4�X%��z�]1���-�p;�����<���s��Z��1��K*�)Y)��*���OG�Nx��q�=�h�G[��m�޻��?
��G׉�������#g�
��c�V��������3�&�����ñSS>b,0�L�0�0�Gʌ�wmϓ������$��T�����K�F�l��<�ʛ�%�e�K�Ю$D�z>U�j8��x�0e��L�W�Zі�E��/��/OR�C��`��O�OjG׆���[��p�Fe	�
W[�~��żMOw����W�r)�e5� 嬢�Jx�4�tl����_ᳬ�	���c�x���:�BG��k�������{���

�a4��9�ߕ=���e4Q�kH.�ح�����
q��./�J5!�S(��sP��^���w�W�#�|�IJ�uy�!GΆ�����v��v�
|o���L.���w��}��O18CMI���H}�G��1�ҏ��=�륅fo4Z��,Yp�i�˄T?�v��������z���z3kYK/ȜF�C���΅X�Jt�6x=�˺�ҡQ��i�������Qx~L�i���q����_���̗��PxId<�s�E��5�	2��'�hm�����+�Q���.J�|F�KD^*�5�7�DRI��#	W�2 �H)r%B�o�g���u�.��T��
:B��tm�8���A�5�Bz&-��*d9\�RZ�T]3���Y�幹d>�4Ѽ_��n�Uq�n������RM�鴊�3�\
�g���RS�TO��4���/�����o��1���|�2M��
�C��{w��n�E6'J�o�ai���0�a�*6r��߸����Mԫ
�������]O<R��ښ]Q�8^�8̰�?H��g�����#�%��LE��n+����PN���<�{���C=��wuW�O���SaE$О%�I\�dF�
�aTM$M�9��>[�
�<ֺb[����@���H�Β�kQ\c2�S���efBAǫ$�M� �NZ� �j�2�ʹ�����^ݗ��ʚ� ��X�6q���S�
�|��8������������kX.!� (|�Y�	{����\�iZ��DQ0C��p��==谐-�Y�O!���\eU�12��9.)�"�� ba�¨]�y���B��
�^З@|P�g
��.�b�Dy��
M`~�E�6?	��Ɛ�mK�[��G�tj<�
��]��8�b�%S�e�J�*BD���I��
^�M�̦܁�6�חɥ�֣���
�`_t԰���i5�N��_�&�<Hr
M���(�C�¦5������z�U�������H��9�P����)��\�M�/�,kD��l��{�������4��rM�_�7��i��`��l!�Sp-��e���*%��4��|i���>���\@/(}:�w^����v2�
!<~�f>���������m���*��M9�l��[;�����.��AW��Z�:_��m�����&/��ql�D&N�D�^!��F��}�	ϸn�m���\�Z+���jT
-�Q-�V�TKHR��h�����:�w�!�u�3m]Y��	~>j�%�D��pj:�͐3�?0v^Z��BU��.�a$��#d$Έ,''�a��͖��2��+|BO�i��W�1��8����]H�J��}Ȼ/�͵��Uh4|��:+}�$��Iү�+�n�8j<�>�&�kGv�u��'Hp
>I����ɉ�0:'�Ǫo��!��>��
{�\��W�
��al����wGow�~��9�.�󮢽�E��m�!8ğ	�@0�C�s�N��c��-ۄ�6k57,+WsN����ْ�NKi+G攬��pUR�~��U4-�����8΋ǜ�t��y�#���yŕ����j�MdQ��������u��V����Ï.�$�M��
���Ġ�����F������@{u�[���*�p�RA3�s%6� /T~��Nƈ@h��A?�7Ѳg�Rwv��*�����7��k�jB�&�0Rf�h��$4�,l��K�<XE*"�he�m�[��ٝMf�I2���v7ɗL�&���N��N�uK��*�� B=���<	
�ȷ�_�E<��>y��y���%^�պ/���_�x��w�G?`�?:������w�O0'֯s_��� 챽p������[|���9�+"��+i~
��#!=,���诂�	����P58��dg��=�ߺO}�^0��A�AwS}��	% �@��2�Ɖ�,�c��dnI��h��f��<6@thk����$U���E�R���ʠ�I\ͥK<Ct�:�NL�ڀ�&ǬGzH>Ψ��v����P
�@
O���xu��#C�
�ň0��"[���&/�랯�Uz�L�<Ş��Ξ�ι���ܠ�����K2�y8Sp͚Xg�"��Г�eܒ��z�YC�<�C�A/`�k}����젟\���3q���kg��X�Kr�')�q2a��ez�ߨv�%>����	ܗ�����	e�)	��,_�x<Y{��g��+0n-�cLT�1:t��9I��+$��ꪒ]��l*t]v|̶od~y����gkU-�x��ܒ�7�véNQ�%�S�*��
�f��,"��fvA�E��D?1
�q��oGK�P��5�M3�tħ")���%��s�.���>����G@�^����Rh�����S�
�3L��P!1���i@�+y<<��x����O�{~�%Bkq�L�(O,s-��Ӱ
r��7J1�&ό����kv�8��#��
��#:J�8���?�[��f[m�~͟�#�ۋi>
7�6���5�wF��V�R�v�D:�@'�8�%�Ve���Q��L0�X0�����Ot[����=n�pq/�����O�\�0�Xi��[�Q	癘�K3�ӿ�'��ю��f�R���Cj�U8�H�
���W�G9A�[c~���}��ـkR��5�4�)ba�Z$�y��<�����@������W7.������d���{(VKß�*ӓ��{�ߨ�$%z�Q���m�m�t�G�	'#�uOwWm˾��>�~-N�$},��JI�]�
ղ%��K�kuCm�
Ր�M�Pf�0�ue5譲�����&|m�v��:��x��eB��G�����l�2�x�(Ѭ�uf���������x�v��St��p�U0&�CQE��ړ�[4z!�w���턉v`���N�����|����u���y���3��!�+�I��
7P��
dB�2�1
t?��܁��ftzaCs'���/�^�
endstream
endobj
49 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [-172 -215 986 700]
/FontName /PHGHBM+AdvTTf90d833a.I
/ItalicAngle 0
/StemV 0
/CharSet (/C101/C111/C121/C72/C82/C102/C112/C53/C73/C83/C103/C44/C74/C84/C104/C114/C65/C105/C115/C46/C56/C66/C76/C106/C116/C57/C67/C177/C87/C97/C107/C117/C48/C58/C77/C68/C78/C98/C108/C118/C49/C59/C69/C99/C109/C5\
0/C70/C80/C90/C100/C110/C120/C71)
/FontFile3 50 0 R
>>
endobj
50 0 obj
<<
/Filter /FlateDecode
/Length 8105
/Subtype /Type1C
>>
stream
H�dTkP���H^�~��a7�u\��4�%�u��MCܩ���$@H�Z�VO��VBHBB�F6��q����v~4�t&���4��L=�N�T�L/�ۦ�o��s��s�9��'?��_�v���9�j���̙&q�DTRRw����V��vr۾��ֿ+֫���w�qw��v{^z��{8B�[��ڻ�_>��W���G�x��{'��T_��o��U�=Z=m��;�^�H$�����,��)(�
D����bh��e%����@C	YZJ
KIQ)�@J��2������dY9Y^N
ˡ
B
B�\H
�BR$$�pU!��"�LDBs9��H��@Dd��,��bR,�6�)"�E����=���U����[/����(��#�T���yU�Sy�9�r�vv�k�"�0F@
̃k`�@L�aS`,�����D@L��`��$�23 ~��
<��`$�,�
V@p?�(�s���8尵�|�9����i6�������'�>�b��͟"�-onݳ�_�nۿ-�����;�;O�*�5��qwf�n�}9�}_�~eAy�g��$�>�����:BD$:^�w�w�����[�q0�;)436�F��@j
ن?�2�ǀQF�c�)����>��kƽ��ч8�����р��4T�ؼ����)���рR.�5�&6`b�~��%X�;D�m~�ݲ�ׅ�:����8���Dq���@�OO6�ͩy�����Qb&<���,���Q�>���s����s��R���rt�G�&��yUR��;ǽ��qUY�;M2�@��[�
S�>dI΢�~=�'<� ��؍�Jt*:����z�i��0����G�uE��>��٭�cq������o���v��3�}z���U���0ʊ�M�+�U�ͺx�ܩv�=�f��
�AW��Ƴ��e�F����|5Ϭ��:#Bk�m�X����~�t#u=���	wr���SN�)�l�kj��Z��Ύ�޺��`9�_�f&�=1"��W5��
���YanS��}�fm�����%۬9I��1uH��>YZ�{�M�7ɛ�McvZ	��8D��p�Ƨ�h��l&Lf;C�zdpC$i����"�
&���D":^@��k+�']�,�m���y��Â�E��Cn�c��#�����$i$1��G��Sm�D[c�v��W�%�m��v���.��*&e�Z��URD%5H�hm�i�o��������U�j&�r�4ORi�JwM�g�0jb|���*�0{,��|�H�D��I,=�hF���moA��\���J�FFC��j��ډ��6$��U�P�A�ю���
RL�`��Dwܘ�G�����Ņ����觌�[�����;�gWo��,}4uI�
ݻ��R+����D���g��/է;����K�p�����`�1�'����(��(���dR�����R�-�y`s�W�U���̌���1e7�ڨi2�>���m����D�2�V�T2��Kt�3�eek?�?z28�쐞
�ɾ�'�AO�m�<�J�	������H��"��A4��Ծ�Z�m^;�,����6�~��p����A���
߫���^Oa<
Đ@���a[��>Q����d@-P�����5d~�ON�elF�7{���&e�l�b�ӃO�.�Z��B���܉� Q��<��ry��}~t��u�p��7���CA��,�7�u�1�V�b4Y���`F�σ������F�y��"֡+�0�u����k7!ۿ��;rAn�[��l��,������n���->�gq�h��v2-xn��W�Fi����B�`�u}�ϔ���h�� �Ӂ�P2O��H8훚A�̄f�$ц������J�ф9��{�]y	�eC,��,Z�ʟs)�����g[�a�Q"
Ҍ��Zx[��c�5������^��~�v��N��ayzN]'i��j�0�����x�֝�5��}��j�7cfzpHK�4H���[�jI%Q)9w������.�^dk��x�~�u��^�i���t5�\&�����;H���E.S#jiS����?ɮ�ض�3�a�n��2���`@;�6�X7 +�.k��]���DZeǶ|х")��.�$��M�D�b�7��رskڦx��e@;�P��/�*�
�'�$�'���������[��������A��q��~��ޝ�y���h��
��uV�h�L�a�Ȅҁ��.�iz*�0�
*	.E���17�@�3,�흶�=��9$4�����}|_߭l�l�,/�׍�����_�v��[ԍ�=lro��W��}/��Pk�V��ܩ�j�@�8��oο�<r�>9u�:�8�����
4����|*�Id�xv.+"R��nb�S�衖Z�܇�w6|�pEZ%a�Ά	$2G%Ìv�����*������P��z1n?E�E�9
���O&�t�֒��%W{���  d���K诡2���`��dx�X����C�r"�;���,r{�����>2��r(��0������'f��A�`9�����F�%�f2I$����O]m��^J&O	1.��g8�5i��h�?2�i�mp�����g��zXg�ٚ���o�q��X�#y<Ʌ� �~����]
hv���0��ȟC��>�T���W����gy��<o�:��xq�O:��x9<�
��?7>~c}S��T7}�U�O��a�����$�z����,g�%|Q����7̟ti�rC���,k��52�Tv��Z���K�V�1V�%��x���z��ǘ�(��$��9}��>X���w��?��	��ݿ��7zs��Z—|�q/B'��)@�Ms�#��E���,*�����,(�L�h@$��B��w��X�(�����҄h�`��g���.c��.�C���H�~(9�C�H�
�{�!�����a�c����P��J	�R��TY���/|��`l
T�c=�>!�9g��S�4+�^��p\L�$D
b�t�uTۑ%�#i�\�a(d*���(/޹ u`���H�(=`�@C�Q�����
���20�f�S8X���c�if{��~��3~O�OI��#D�"A�6-�8/&�"deU�$%������I`W�h��R4NS<@|�l9��������U7����ju��\�-�����UxKoꚮ�ĵT���v<�n͛'�A��� �X�
I?���cg���Ngy{A�4�"��p}7MYe��W���Z5��
��
�\F�
�
��6�0
��E�=z��`H�����E�ZZ����?�	#��=J\�T�:�f���ch� �9/J٤�c�a�V�L��\�̯�~p�^w�C�'Z��W���6��Hf&G�X��G4�R]44gĸ�If^Z��o��S6�9�5EV�b��^����쑶����֪3A��`>����Q���T>`u�����1�,���C����ҁG�Qj2x|�u̜h��*A�[����])ufrخzN.	h��-�)��W�OZ��b'd<�@tQX���BDǨ71��ĩ�E{hr:6�$��
e
@	L�IByq)���m����[Ao^�˻�n�Y�6��zy
�
��`+�݅㨭�X�?�%W������@��^�ˎ1blz�"	�Ǽ��������	��)�D�B7�7N��������ps��}�#6�Kآ�[�9j��
�<��#Ra$��&'�y����X"1��'
���EƋF�+:bd�R{�<���d���1@�z�l�?5ˮ4�8��B"�*τ�yG�ё��kh(��؁������eTR�<�A.FK`+��d�ސ�k��Z_0���*���%���
�f��7���Q�,���Pj�2V�,)k��:�k��ɼ�B�s
��61�cp,�%Y��/��x��>�sL�`:��z342���ΝE�r�IL&*����wz����g�azt�pf�T?zvP_�/.��H!U�,`!�7V�Q��Z!�
IkZC�׍y}A���jv�Y�i��g"��`q�9������w�h=+#��.ŀ���z�}�|�u�u��cU\���42���}`+�c��վthτ���Z��2 �_�VuU�<F��ץ|� �Ҷ��ŃFR�IQ�8a4Ob<��[�֟�t���{�{�VJ��.JY)'J�"T2�)R
��'j��xF$��K<�X�vצ�_��-�m�>�暇
4��Q�e{����f
6ۊ.Y�ƞsk��˲.֕ER$%G"EREI%ӌ�8�%�I�dY7t@��dî�À�Ş�@�_v0z���9�9�t����]o*�C	�[Ku���Dl��l����G#�wOu׆��ƊY�U%[F
����<t�<�Ȟo�W�������-FB1�"��I�;��P��=w�����@�;~���ZRђ	9f�ɅI||f���)d�qv�V�(�Y�
lG�8�F���)Oڟ	'PR��,}V�X�����,w�'�G(�X>+AȉY\��$oHy	+�}��ۡ2n���J�F�z����?��y��I���Se�l�{��G��hu��B��M�1��cϿ�
�
-��֛�U\�E�EY.�����v�����>{{��=������C������]j-dcvh^�� G�� ����Y������~���Vg��W��6�L&^�������[��������|Ѽ>��z/u���f|� Lz����ãu�������Xs�Y[k›����Z9�i��s��$d3XVx6Ͳ<��,��s(-2p�i���@�T�5\7�Zm0f��1�:.\ �����ɫ�q�7���zI�v�(�
�>����u�c��;ۃ������
�b�W'ȡL6%PX��0j���'YMꔂ(IB���Ira��r�{�;C�G���E,l6S+�^�̛�������ѷ=������R�XZ)
:���:䊵�ط��?��,�s�\����գ�di��^�=P�����g�?=��9����!?�
?�+�o����`O�v;����)x�a֏��)�X�-�o�چ�Kk�iA��KN5�Z����_�
��I�E��or�;�xG��qtJ��a�������O������3�Ë���(��7�Y<l�+���3�vcX�ݵ'7nm ��fTu��
�-����� 	x��9�*3�6�J7Ÿ��z�h�6��Mѫ������|6/h&�,&�YN@1-C���l	���
�Z��:
#Q�t"�A�ϒ~�oU�[�zcW�y*��L�N��IRѥ�ͺ�>�j�����K9���T��'�	E�'
'��<�ϊy4/J	SdQQPؔ8��t�
�aY��d!��Xʨqu�n��6���|����o?����;��d�x{p�z#�o�	�P�/1~x6:5�OLE�\@�5#�5B-b���œ$�$86%Y��+�
�I�L�bK��ƕ�����r�6�0�7�mpo[ѷ�-�eZM�jj+�d�D
�Ug*���7=A�(p2�����bA�������⾹�A6:��]���r&��!������ᦄ��8?N%^��Ną8X��UOTӖ��շ�Ml�n�7�]gI75쇄�'��p�%�OY�z�>��)�J��xd6�%f'�������1h]��u����t�%��^��@SN���4�o�_�Y��Э�UG_1�G�>q�U���8M�钤
��$\DxRH!�b���\��'QJ�U�RU�*�ʒa�5�jXV�^2��'�Fb$l����:ԪT��(���Q��Km�&jr]�4:)`�:1?���_8y��ݗ{�C���M�x�8-@}�RJc0Z�I�p�X(��k����%7���;��k��ج�PT2B
/"���g������\�O�P(%�E��?U�x��6;�'�
�wpi��rR��2*�e��>�~�:?I�?H�H���$����T ��uŇ՜��r�\�I��:�7ؔ��aQ���%r,1��$�!��_dsK�OޓEI�TYRU�5�/͊4��#�	�&�
F����cv��;�[.����ޏ<G���7��a�Zʫ�^dx���GrK�%#��_=x�z6�����~��{Ǎ��h�
�5�\�M����^L�#�E��t�H ����uj'�qj�Y��M�Vl�:+U�V4eSnHv�P��n�Ea�2�KY��Y	�$��e���Is,L\�����.�M�+G�T)AW*k�����9��I֠���$L�
3*��p�eP5咅;�֭�R]n���U~!�O+�6RK�����B��Ҿ0		����n/;��N�6�㸱��V��lj'm�4MzI���tK�Y
e�lF��$��A$�Ng��w���9��}g�(m�'V����uX��:�5_��u V�;
Q$�B͔.{�}!�9�Y$3~��������ط�;���ͭz��>�`E�$��R\<;�|�vp�ύ����}qxv��X�V�e�{��=ʮ�_X�=�n�Ar��'��e��AҬ��
ݱ�6����	#H�p�-�sA�y����u���}ӧ���:g�1���h�Z��#o_�����/���f�l��=A����9:�����D"{�؍x��|�B�&��E
L�����s,0��ꟁRO��c���պ��k�m6�}>nX/n� n���nr�^O s�7VU5k薳�i���c�x�E��g�*,�G��4��e��ϥ�9tn������E��޸{8"��¦�1x�]����&oF�42�Q�ja�������1z��4O��I��d����k�kב��37�XR�^�7vB����|���9�?�7ja���žy<�};���T-Kl��������wW����8�H
��ƹ���A�+�/��$��V��t�-�z�_��
W�x�m�/�݋3����I�j'6��Ģ�/`YC1bnazl������g����U��������_��v%GQ"�D44��ҳ5��Vbd,�L�d��
�pm3�18M[{�$���
�=��.�3���#ߟ��cI��+�����;�ۇ��j�\�HRI�Q,�&�������^�tԨ����)���i8��M�;�_��?�t���2�z?4���)��R)��P>����T�Z^B����|�Sz
��Zt{f{�1��BvL�$2
8�E�5 �uz_<�p�B�����%���.�%�noq
�^�l��V����s��iD�ǎ�*U�
�3D����YBJ�����5:QE����T�o�W.c���&��ƒ��9Es�����~�GMq�`M��)��;5����vf�I%r,�
hb^(����!}��w�H�;�7����@�^
�IMƿ�N�
%gc�����R,EANr4��$�7��II�*�C��o���Z�	�|�����O��8�ዑ�M�
6:��)��i���*H�0`�2���/�v�f,D(+%�eP��^��`���������0�x\LS���J�W�V��n�%KAl:�`9��y���XT�����+�i��$��s*QD�v�e�?9���=��|�������&�X�
��K��QI���%[i�fƦ��i�CY�F�&M�r����O*�M����(6���=�V��lҍ�W�����k�a������s���׳8��G��4 ����XYgP#�Qh8��9��<��
L`J%��@��h{���s�J�gZJ���������Y��*Wb����
��9I
�U8�mN��['����@\tX6�Fy][�`Ӑu��B�28��C�$L3�Ƞ6M$A�i*=�� y���&cg�D��ҧNQ�1��f���)m^~��$K���X,��$p�(‚�ϯ�LAuA$���y�d8��ł��ef�w�7`��W6ЍJw����>�8=?=�}��B�n���
�L��	��}�Ej%Dh�ATFg
�T��Qx @��!<�ʼnhdty�Mc�����r'�.o�6�P5������ӽ�/�/������?��M�
endstream
endobj
51 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [-11 -345 1373 718]
/FontName /PHGHBO+AdvPi3
/ItalicAngle 0
/StemV 0
/CharSet (/C35)
/FontFile3 52 0 R
>>
endobj
52 0 obj
<<
/Filter /FlateDecode
/Length 829
/Subtype /Type1C
>>
stream
H�,Rˎ�D�w��%���4l2;�,,Ȏ�@��a����v���N�n��~�;A�$$��u�����Qբ�Tu���/�������}��_��>���C���������9��u
^�������ɫ������>���������.�V�G�ī�����=�����&���<#4B�%�(b�2�S'�2�[i\�Q�ڬ���7'k��P�����	��Z�ؘ���>VS;��WuU�u�V}��%X
���:
a�{��ݵ=������A0
X2%��g�J�pj�s��I��@9�iM��8T�J&gp��o�-{J9��^�M6dC!
QvU[7M��7���piȇ�$
D$}<��>OFk0�)P��p�0�t��w_�4�8LBP�
"F���.p�^<�Kwg1L1���T��N�:Ug~.�}���l��HF:'[�Ek����'{�gs5Fc�wz��(�T�
�
(43=ә����L�#�3�@By��XV1BB�~�n��ֽ����a	����
W�M	K��5�`�ЌV��g�d���߂-�ۙ.�,t����.ْV�Vl�Z��\O�܎��0��<��:��ڬ
��\):Ђ���B�`hC[s���jFz�H���"6��(�� ���C�*����V��^hD�yW�l���޲���������-��+�v��)]������Yu�X�����~תhD;5c5�j�m1�
֥5�A#7�Y�d�["h�³�6o�7{qG{4'4�S�k�^�`�հ�a���7��X�fS�*D���6��
0`�
endstream
endobj
53 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [-27 -215 1009 696]
/FontName /PHGHCA+AdvTT2cba4af3.B
/ItalicAngle 0
/StemV 0
/CharSet (/C101/C111/C121/C52/C72/C82/C102/C112/C122/C53/C73/C83/C103/C113/C44/C54/C84/C104/C114/C45/C55/C65/C85/C105/C115/C46/C66/C76/C106/C116/C67/C77/C177/C97/C107/C117/C48/C58/C68/C98/C108/C118/C49/C99/C109/\
C119/C40/C50/C70/C100/C110/C41/C51/C120)
/FontFile3 54 0 R
>>
endobj
54 0 obj
<<
/Filter /FlateDecode
/Length 6797
/Subtype /Type1C
>>
stream
H�dTkP��5H��?+?v��4MjO�&$v��lSc�v]�q�X��VZ�V$ !�"KBo0`���
4&������Lϸ��d�I�M&��ܥ�.v:}�8�s�����ν�A�2
`ひ]eD���7����OU����.x楥-,��eك+74pus>�+d�\��Y�mX����	�
.l��
���۶?[PX�܋?ݵg߁�C���TԜ�oj6�i������H��F'�ffo~DH�T�#_J��|�8�'yHy������(.�I�B&#�2�X�<�2B&'�r�PN�y��TN�
��B���'xH�UQTDHy���<�"BVLȋ��b����xH�	Y	QR¯xHKY!�#��x��4���m.u��_2�U������wJs~&({�����'��ip@?�`\��
t�^#�,��3�t�8H��A��<�.
�?��C`L���
��0 
��S`��N��G+�D�����e��n�s��O���儵�OEWŇ!�����og����V����cӫ����w�8�µ�u�֫���s�]����[7�lRn^�y�Gn�����lY�er���}�*�3�wJ$ϩ�**vŠ�
�~�^�����Ž�7���t�)J�Gȋ������?"_�>]ǂ��㱡�@26�qq����H>Jߺ��'p���� ��C�=����a�xHׅ����	�5�T�K�#O�wR�b�c�j��jn��j�f����8B�Nx:��������8=��a1]So=���)
�(;�Et>=cŒL�E�^og�tz=��im����Q�j̠nhVPP��[�;"�&~�N�����k�J4�uuZD�'CfE�q4����P��!1{�
a!��kQ�P�{_r�zK�>F�4�զ`�F٧@J���Q7*�J��9��@*|��J,P�w��FU1M��Tj�>�f��`O‘x8�?<��7n#�bn{����n}�^o�o���-j�t�m����oI@�9��/�Eϟ;��A4�~��A�}Nڏ)���cP�QƉ�z���$������h�Y4��n��~g��k�^��T!ܗ���sY�6�:-:w=�׳_��"���������޶���X�4�:��D/�hlF��ᰵ�n�j�jP�)��ܽ?�L�gf��=I�1*�<P��z��=\eT)q�J}԰/��4����G�Rm����A������o۹ܓ��>�g+�{�{���a<�UGT�&��z��	�W���𺔞i��N��Ҩ��i�jm1]�!l���)ۯ�������l��d��e0]�L\<�2q��|�2nQe��J�E�U��xu�ꔦ��wvx"yL�d���D�$i�I��d3�j����%��6	�න�����g�? �~����]<��-g!�p��{#�=I������^y
��<z��5z�#565j�z:i��e��1u1
c�]f���팴��bB�
CԄ��iz
����Ƨ��C�0~!89��l�Zy��Ky���J���2�9v���ɻ"[��y���nEe���|��r)R�s$z��H׍j�vt�:���DF�H*�ᱞ��a�v��
W��f���]V���;���f2c��ĕȻ!���rJg���DĪe�XM�>)R�|�b���݄��A�B�!�4�O�.^B:F<���{�m��M�����0W%�����p4�Ԕo
e�����i�#����H��3D���T(∡��/���q�둇^�=�:w7�_
�X
�D����G��;��_�e�h�g�Ӊ�.��sX�n���o�"]�M�}��mΖ��D�8�bRs��5R�)����PϪ��<Z��R~A��p �e~-d��"Ø�;"��%�đKc���o$י�h<	���02D���uo��f S�����@/p;{�^���i�M��*��R�ҭq�0����
`mnU�z�3�D&������<rE?�����{�!���}�_m�y��!SP�dw�D�l������Z�ښ���2�ܹ�:�'騁i��?��ض�3��D���!�]��e�t�/4H�6�'�2��ǎeGVd��(R�%J��X)���HJ�%YvTEVm��3��Y�k��ҷ
0`[۽t ?���lMۡ���9���w�wg%�u��$0��}�`���R�TƊ;>��K��Ú��>��yu�}Q��DžbA�yʼn��C��>�J?�?=<2����}��}���ϰ��ͱ;.���=���L��wK����\��vP��]��39V�o0;���{�>��ʷ�bge�U�VGل;����1]*�
���,j�ﾺ�����m����

�Z�ִ�B6����;��v���k5P|%�=�ۡ*65�v"ͥ8�
%<���{�a,丠ى � A�H����}o#�������1P�y��K����_�&fF���HIF��b�b����-
�5O�cQo���Q	eJ
�q��ť`q�?Ņ�qXt!�q<�L�kr1>T	��I�f��a��/�+-�֐�ׂd���Q�P��P6�27 ��8���3�k�X�_�O��{����2>P=�0��Y4a�O!ח�)	�$	 �-�tXV{P�'e|B�^_/`�=sF)�g*j��
'�cN�Q�=)�N���Q7��ڿ��?�lʟ
ﱔ�κa0vz��}WIr���L�
�mWȥ$���p��
���M�� �x��XzY�j���֞��m���m�`��1֌��/�{�{����p�x	q.�1���l���a6����%��js���ˡ_���~ݟ@���?�+6#�����SOD>!��y�)�����'*�=���Gsj��
Go�qI�Q�(�P�Q��޷��]y����ֺ��A�lk���5������߅��ft��b�@t�ME���ɓ�'�Xn���'���vm�v�\���d� �A1��n���.c�����f�E�h���H4�`��N�^�I
��$	��_x'��K���
�Jڕwcy�>_��<۳g6���(r~�$F`hԽ0O�[1�G�c���=��K�61���i f2��s|��7��*xU�U�����6�խܼ�n�7�-��h���_�Ԙ�'��E��rt9��*�j�Lnu}�x�Q��
�1܇�V�r�iI精���u���ցd;2a�
���/� �J,��+%&G)���^%��aF/?>aoh��l&�Q�Bɹq��9'��Ә:ռ�Es��߽Sh��Dce]n
�%�{5RH=�	YL�g��$���`^�Q��V���J!�b �1�e�d���X���5�~�����b��I�)�4������$�S2�ʈiY��&k����n�cF�{r6C��Η#5�]b����Z�2�	6�p��1�O�Sf���k�2j�Dv�k|�*>}V�C��<Y�����<�"B�J�L���R����(���E4ɳy,(�R�RbF��\I����[��a�$Lt���O&�.�t1��-*��J��oWw��א�1/A�2_�FsETK9�j�+�e�����/�(�����|:*��@I��=xTD���RZ@?�*|
nv������k�@��o�F��
���-O�e�욑���Qrl7k߼ul�V/6`��rxɝ<������0���!d�<
IZTX�U�BLqe���#��>����e;��~sJ�L����t���4謹��7��]��ְ����,E9	Os� ��Ҽ
�ѡjjm�nV,�調�bUׄ�K�򹙳c�� }���z�=�
�w���ݒ�u|]�7+]��XF�T˃T�1�|�EE�ԦZ�I��<�թ�/$�W �c:H��Nr��|���A�Ln�1�
�ޜ�+e!��\֖�e�8�>^B�@R���Y�T��6��l��|�m{/���.&�a�QX�k�P�ߺ��&;R
�VdU�Q��
l5燪����6b���{��8ƴ!�?8?|"�~����ڝ}n��՛xS��W~�OP.I/���z���\���-�V�!0R�l��\���+�ng����%���"�%F$�H&'У�����7�:NE7�]9XJf�P/Q�Px\(E(m	m ��湻٧wm�g<��3�����{<������n�l�&���*ќ��8qFH���oRҪBh������{�������H��#�ZӴq�t�LM5	C��d�T��.�-�+�"���Z��P"M
�v>�rƾ��z�05ALL�Ϡd�����ȼ^�����KY���~�Ffˤ)x@���:��P�����)orҚ�^;MO�cW��g�qg:J�Qz=w�p�0Gщl�\�����))'�5��j[����}v��ɹ�����ݵ[���F�nǠ��,�����c�O�/aG�#9�fK0U�C�F�uq���
��D�*�[1�ub�_�=���
��v���b���_�
�u��Q>� ��}�5��<�Q8�$�'�.T6��ͷ���l��f�Rx��BީM����d	�qt������+�1���/�,�f��M7�n%+�W��FiMŔ�)І_�1�+)�XdJt��F�*o)�$�
��!~�lyp�f��l[+Y����jB5��,2����K<��C����8@��������%���-��-8�X&S��3��4�	����_�ɝ�$�%F�H�@R"��.�V�o�1I!�>C�9�u��S�ԡ���D
�h��� B&UR�q^`��GW�H���%H���@��F���O���L?;4z2�2��e�~�dh�%K��Y-�Gב��ЈT�cx��p
�k|eEQT��Z�D(��4���z��͊QC�![�-	5c�� ��p4�0
�5��ֆ�����k��k����a
l�p%n>���Fr���'dm�o��#>i�P�����Z�t
����fѓ�����|�����ݽukm)���v�U@8x3�髶,Ő$T�DE�[��r_{�0,�CT2*>���x���������P�Gw�O?�eR�e���i�g*.P\-���H��
�
�h&���f+uɀ�-V����/�9��%\�J�+�$h���g+�%{���fr�-���>�<U�dA���/$GM r�L���M�~��W�;��n�u���y{
K��������3�U&"}������$��&Ҙ��o�?��KU�z���,X:r���~V�U��p9�-�4\$���O��9�jۥ.��(�-r����3
��g��<�p�Qu�J��'�G/�NQ?�	�;����o2�`���
bc�}�
z[�I���nzm���ˍ�PE���P��3L�\������*Sx��$�WY��t��-��5}�:���kc7��%�	<ϷZC��_~'��LKB�XZƶ���*��k�.�w��w�[�
vgwrks1��N7&�ٴ�d�X�p*�~��YdJ�C��U�2����0UC"$C1�R�[�h�|���C�|����Ģ��o���1��x���)�ilr�sc�������:�$�D�|B�|T�"i��$�qx
��+�|�u&���s�!3�4v�r1;N�g�&�s�<'�=��h�Z>��r�m�Sz=�]$�v'���*���,�pIc8��Hډx"�*�}����(��c��X�<7�K���I��M�D�Թ�![zC3US5�JJ�栎\P�e�E�D&|���W�\q���9@������٭o���-�p��M�0ʺATuKi
���&�{�g���*���7��Ia٬T��Bzj����Z+��'R�Ț���L���Hx�s
;3��B���k_q�c��Q�s�Ml-ti�\���-���T�,�q�H����C���H�P�r�f�����59�V�,o�X��N�������JK�"��S���Ӌ����vц��8
��ݮH�D����3�}H�{� �N=�r*{a~|vrfr|��,���"�*�F��M*�[Qԓװ��?Z!��ȕ<Y�aJ�ZW��n�.�W����sw���;����/�
�����,�"&J�!r�din����>Z�3��2�F����ͬOE`�E��,/�����N����'V�%V"Xɣ�Q\��b�Q��\v �m��0E�A!a��4E���s�+�������?4��kA�OI�TIwa�A�A�B/^�P�B�����`[l��v��n������N&��Mk>���z��ͣ/
��R&�E��x�y������W��@�1o#�
�v�L`�V9,����q��_�.Ȓ?�{�G�
�
���4iP�Y��s~6��!����C�6�Ȇ<����ۖ�	
`�Q����.�g��
z�<bm�F6i8-��W�≭��]2�����9$��ä��9ν��鴽��A#�Ja:�����ӕ"/���!hV�㦽m۬M����د��1JF/�|�+�>y}�{|.�h�x��(�㲰��R+DI��)b�uh F�����,��!Z���w�R�����t��l#ʈ2�|+���O��b�X"��yqQ���
�KN��9aB{lD
e`E�EnC�d�G�@\gW���&]j���`Нh��>��$g�Q��9<p�8'�D�����JR�u���=�V�O��)���ن���k���%-|Օ9Z��!���mi�L椴4���,0���&���5��O�t��4��]�a�m�A
�(�[:�'WR��,�c��;�f��vzlhd���`��
endstream
endobj
55 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [13 -323 958 824]
/FontName /PHGHCC+AdvPi1
/ItalicAngle 0
/StemV 0
/CharSet (/C54/C56/C39)
/FontFile3 56 0 R
>>
endobj
56 0 obj
<<
/Filter /FlateDecode
/Length 478
/Subtype /Type1C
>>
stream
H�,P=o�@��[����LA���$��HD!��.�AJU�v׾��:k�}��	蒈�BA
5�����b�޼�7�{��������v�{���Λ�Wȝ���b�����~�b��X�y��͓��[^��{��Z��8�،=�/�ջ�O<_�����z��s�v�o�~/�<a���@e�TP�oMxz~zn?)]hPAK���L˴��J0	&"a	��O@��x��C���v72��쨐Ͱ4{��� ����f�K�e�Uo�����L�{͐����=��/�?��!�c��	J�98�A��H���k�#�sV��\:銺t���Tϔ�hS���U�#g҂9N8nSG���iT����K�$F|��%`�.�SSYe�[Ye@Zha��vb��3Ra�E'E �Yb�c����d��1J��g��H�G.����Ć+jRǍ0���+�����K;�d
endstream
endobj
57 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [-179 -292 1090 1010]
/FontName /PHGHCE+AdvP697C
/ItalicAngle 0
/StemV 0
/CharSet (/C62/C109/C60/C61)
/FontFile3 58 0 R
>>
endobj
58 0 obj
<<
/Filter /FlateDecode
/Length 314
/Subtype /Type1C
>>
stream
H�bd`ab`dd�p�pv�vL)0�4w�I��g�!�#�����_�~��>x��^p��3B���,�|b�fFΆ��f�f�p�,6�v������� ���&�g��~�������$����?�����X�CJ�Ϣ���~˳@|?��!���{�/���������H=�C�O{`uec��g���e��V�>� �x�jn�Q�E�3פ�^�n��E���\8eƤ쮢uE3�T�^��䭓�r���T��T�7T�U�標ռb���?���E%
�Eݹ38���o�%��!;ߏ="�D
JP��
endstream
endobj
59 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [-253 -211 1078 766]
/FontName /PHGHCG+AdvTimes-i
/ItalicAngle 0
/StemV 0
/CharSet (/C46)
/FontFile3 60 0 R
>>
endobj
60 0 obj
<<
/Filter /FlateDecode
/Length 182
/Subtype /Type1C
>>
stream
H�bd`ad`dd
�p�pv�vL)��M-���J��a�!�#�{���_�~Nb�)p���`�wO!&FF>g3$�z�� )�n����l�jfmb�i�k�o��2�uR���)���٦�M��7��ľ���'�L��:��sJ���ɭ����Zz[z[{X[ؚٚ;Z:Z�Z��� �0�C�
endstream
endobj
61 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [-217 -269 1003 939]
/FontName /PHGLBA+AdvT001
/ItalicAngle 0
/StemV 0
/CharSet (/C101/C102/C112/C114/C65/C105/C115/C46/C66/C76/C97/C117/C108/C49/C109/C100)
/FontFile3 62 0 R
>>
endobj
62 0 obj
<<
/Filter /FlateDecode
/Length 1799
/Subtype /Type1C
>>
stream
H�TT{PT��+�{6�t#��4��{��4�I���6���(� �A"�����`�>X�e��e�<vYvY�������f"b��(-�d�I���鴶��Ys�L/e�G����9s~�}��E��׉(�z1��C��o�_��OMM[}B����_x�(��w�������x���(ų	h7�R(�~�{)/}ڲ���Rwd�= KKM�,-m;e黄���]����tYF�lO�p��[�s�p�"��"��w���.���>)W44�4"�E��3T7�<Te��(����SN�+J<��E��X4O���e����BRE�t������a�e��J�ÿH�&�bX599<�T�ȑd�Ŀ�~=�38�>c�9���]�
�6K��S[Ԗ
��Xy��3���g(�g �{i	�&�>+��2���z�+�x����6P���.?��7�8��&��
uw��U4�e����x*lc��q]p�	��g]J~"�r�&]��s�<Q��)�*r��2���,΅��}@2�{�)��5d=�*V
Vv%����&�`h�<��Y��\B��3�K�M�l�9�1����/&J|S�=vF�G��g��U�N�	���|��!�%_}���ùo(4���i hz�	gI������|���Q��h[ļRm̓Dʘ�%G�Z0
�����\(4�v��ar_�}qMw��tw���vT
���΢%�	�壘F��jO��G���7%����$S֏C�\/�З&�澈5�����N����m��Yl���۷F�s:G���5�b�q8���`����"sKOV�kaY݅���q���h�$O�ܳJ����q�x���Fj�*H6y�l&)ڊ�ݾ�>������
����n�u���QbY���7+��*��
5p��'X�E�X��^]D�&'�a�H�����Gg�J��aIe��ɯ�wn��0�08ɞ����{^'o��F�P��"|��B[q��T1K�k7��ŋ�w!��D�T�9y��\���mL�1����o�o�8b��3��Ǎ�D�cp,b:C�"��0�F"ѫ9��WWP�45m��
4
�X�=���]~����V�yZ�X�Y�2y�Q���<ք��1��M��4�B3��T�V�R����ĸz�����ʤz�l�ȫ��n�N�Ũ���AÚn�0;ESd�M�H�,���y���w;������[x� �a�eI
��FZxl���qh	�N�r
���+�8�16����ŗ����9Ƶ��"��a��!�o�yY[�v	q�}������+p"9 �Ř�b
�ː�vN��s��+�K���̊��uZS�����|�,VUU#�����v��.�?���C^���vX|�gq��Y=X����u�M�F�cg��~��pj�b�\��ĭkh�F��Co|�ﯝ(�T�rfs{�I#� ?H��0�
���������:v��Yl�)��|���L��*��*p��A��w�[[8���Y�f���ȯ恧�����G�=���E��i_��
E���qy}����M����o�TKBG�kg��
�\�~����0½�?ۗ?��m	z�7�)e�k�ˋ����r��֐5&6������^�s�;"��ܰu��G�����M���+$�.�|�������ݹ��
n��H��^�<̝
}!"�@�0�f��Z_3W�i����Л��z��v��ƞ�v��?�O�{������l��Ћ-ζ��AEu��*B�f�>`�L��3�G؜�������KM
endstream
endobj
63 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [-29 -959 1117 775]
/FontName /PHGLBC+AdvP4C4E74
/ItalicAngle 0
/StemV 0
/CharSet (/C137/C138/C133/C134/C0)
/FontFile3 64 0 R
>>
endobj
64 0 obj
<<
/Length 353
/Subtype /Type1C
>>
stream




PHGLBC+AdvP4C4E74


� � n�S������
����

	
C137C138C133C134C0AdvP4C4E74�����
�
�

�
�

�


m��������u�wu����������u����������z���k�Q�-�B��B������������1G�PX��7=��
�����J����������ـ�
T��O5́��������y�(��3�e�?f�D��~����������������� �����*�,���| �3���c��,*c��

endstream
endobj
65 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [-27 -221 1248 728]
/FontName /PHGLBE+AdvP40798
/ItalicAngle 0
/StemV 0
/CharSet (/C124)
/FontFile3 66 0 R
>>
endobj
66 0 obj
<<
/Length 173
/Subtype /Type1C
>>
stream





PHGLBE+AdvP40798


��p�q��l�����?

C124AdvP40798
|
�

S��|����A�H�A�mk�,�'�^�������>�9ab��m�������-�'�N�����Q�Lr��i�d��~����i�c
endstream
endobj
67 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [-217 -212 1005 766]
/FontName /PHGLBG+AdvTimes
/ItalicAngle 0
/StemV 0
/CharSet (/C49)
/FontFile3 68 0 R
>>
endobj
68 0 obj
<<
/Length 207
/Subtype /Type1C
>>
stream





PHGLBG+AdvTimes


���m�h���������a

C49AdvTimes
1
�

x�������������������������������������������p���������������������}{���w����������������������{�4<�����
endstream
endobj
69 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [-29 -209 1000 779]
/FontName /PHGLBI+AdvP7DA6
/ItalicAngle 0
/StemV 0
/CharSet (/C35)
/FontFile3 70 0 R
>>
endobj
70 0 obj
<<
/Filter /FlateDecode
/Length 130
/Subtype /Type1C
>>
stream
H�bd`ad`dd�p�q��vL)0wq4�I��a�!�#��;�W����W�����..�������ll
W��������`����y��џ:�mXw����]��������$�9 �W'��@�
D�*�
endstream
endobj
71 0 obj
<<
/Type /FontDescriptor
/Ascent 0
/CapHeight 0
/Descent 0
/Flags 4
/FontBBox [0 -187 990 742]
/FontName /PHGPAE+AdvP7DC6
/ItalicAngle 0
/StemV 0
/CharSet (/C117)
/FontFile3 72 0 R
>>
endobj
72 0 obj
<<
/Length 115
/Subtype /Type1C
>>
stream





PHGPAE+AdvP7DC6


����O�r�z�����


C117AdvP7DC6
u
�

�����>�w�x�w��M� �#� 
endstream
endobj
73 0 obj
<<
/Type /FontDescriptor
/Ascent 718
/CapHeight 718
/Descent -207
/Flags 32
/FontBBox [-136 -225 820 931]
/FontName /Helvetica-Narrow
/ItalicAngle 0
/StemV 88
/XHeight 523
>>
endobj
4 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F1
/FirstChar 32
/LastChar 251
/Widths [281 333 479 552 552 885 718 281 333 333 385 583 281 333 281 281 
552 552 552 552 552 552 552 552 552 552 333 333 583 583 583 614 
979 718 718 718 718 666 614 781 718 281 552 718 614 833 718 781 
666 781 718 666 614 718 666 947 666 666 614 333 281 333 583 552 
281 552 614 552 614 552 333 614 614 281 281 552 281 885 614 614 
614 614 385 552 333 614 552 781 552 552 500 385 281 385 583 0 
0 0 0 0 718 614 666 614 833 833 0 583 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 333 552 552 166 552 552 552 552 239 500 552 333 333 614 614 
0 552 552 552 281 0 552 354 281 500 500 552 1000 1000 0 614 
0 333 333 333 333 333 333 333 333 0 333 333 0 333 333 333 
1000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 1000 0 375 0 0 0 0 614 781 1000 364 0 0 0 0 
0 885 0 0 0 281 0 0 281 614 947 614 ]
/Encoding 74 0 R
/BaseFont /PHGHBG+AdvP6EC5
/FontDescriptor 43 0 R
>>
endobj
5 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F2
/FirstChar 32
/LastChar 251
/Widths [281 281 354 552 552 885 666 218 333 333 385 583 281 333 281 281 
552 552 552 552 552 552 552 552 552 552 281 281 583 583 583 552 
1010 666 666 718 718 666 614 781 718 281 500 666 552 833 718 781 
666 781 718 666 614 718 666 947 666 666 614 281 281 281 468 552 
218 552 552 500 552 552 281 552 552 218 218 500 218 833 552 552 
552 552 333 500 281 552 500 718 500 500 500 333 260 333 583 0 
0 0 0 0 718 552 666 552 833 833 0 583 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 333 552 552 166 552 552 552 552 187 333 552 333 333 500 500 
0 552 552 552 281 0 541 354 218 333 333 552 1000 1000 0 614 
0 333 333 333 333 333 333 333 333 0 333 333 0 333 333 333 
1000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 1000 0 375 0 0 0 0 552 781 1000 364 0 0 0 0 
0 885 0 0 0 281 0 0 218 614 947 614 ]
/Encoding 74 0 R
/BaseFont /PHGHBI+AdvP6EC0
/FontDescriptor 45 0 R
>>
endobj
6 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F3
/FirstChar 32
/LastChar 251
/Widths [250 322 406 500 500 822 770 322 322 322 500 562 250 322 250 270 
500 500 500 500 500 500 500 500 500 500 270 270 562 562 562 437 
916 718 666 666 718 604 552 718 718 322 385 718 604 885 718 718 
552 718 666 552 604 718 718 937 718 718 604 322 270 322 468 500 
322 437 500 437 500 437 322 500 500 270 270 500 270 770 500 500 
500 500 322 385 270 500 500 718 500 500 437 479 197 479 531 0 
0 0 0 0 718 500 552 500 750 750 0 541 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 322 500 500 0 500 500 500 500 177 437 500 322 322 0 0 
0 500 500 500 250 0 447 343 0 437 0 500 1000 1000 0 437 
0 322 322 322 322 0 0 0 322 0 0 322 0 0 0 0 
1000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 885 0 270 0 0 0 0 0 718 885 302 0 0 0 0 
0 666 0 0 0 0 0 0 0 500 718 500 ]
/Encoding 75 0 R
/BaseFont /PHGHBK+AdvTT5843c571
/FontDescriptor 47 0 R
>>
endobj
7 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F4
/FirstChar 32
/LastChar 251
/Widths [250 322 416 500 500 822 770 322 322 322 500 666 250 322 250 270 
500 500 500 500 500 500 500 500 500 500 322 322 666 666 666 500 
916 604 604 666 718 604 604 718 718 322 437 666 552 822 666 718 
604 718 604 500 552 718 604 822 604 552 552 385 270 385 416 500 
322 500 500 437 500 437 270 500 500 270 270 437 270 718 500 500 
500 500 385 385 270 500 437 666 437 437 385 395 270 395 531 0 
0 0 0 0 718 500 604 500 750 750 0 541 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 385 500 500 0 500 500 500 500 208 552 500 322 322 0 0 
0 500 500 500 250 0 520 343 322 552 552 500 885 1000 0 500 
0 322 322 322 322 0 0 0 322 0 0 322 0 0 0 0 
885 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 885 0 270 0 0 0 0 0 718 937 302 0 0 0 0 
0 666 0 0 0 0 0 0 0 500 666 500 ]
/Encoding 76 0 R
/BaseFont /PHGHBM+AdvTTf90d833a.I
/FontDescriptor 49 0 R
>>
endobj
8 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F5
/FirstChar 33
/LastChar 126
/Widths [1000 1000 1000 1000 1104 1000 1000 1000 1000 1000 1000 1000 1000 1000 1000 0 
1000 1000 1000 1000 1000 1000 1000 1000 0 1218 0 770 1000 1000 1000 1000 
822 822 666 822 666 718 822 718 666 666 718 666 1000 822 822 822 
822 822 822 718 718 822 1000 666 822 718 1000 333 1000 1000 0 0 
1000 822 718 822 666 1000 718 1104 822 885 1104 1000 1104 1156 666 822 
666 822 937 1000 822 1000 1156 822 822 937 1000 1000 1156 1000 ]
/Encoding 77 0 R
/BaseFont /PHGHBO+AdvPi3
/FontDescriptor 51 0 R
>>
endobj
9 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F6
/FirstChar 32
/LastChar 251
/Widths [250 322 552 500 500 1000 822 322 322 322 500 562 250 322 250 270 
500 500 500 500 500 500 500 500 500 500 322 322 562 562 562 500 
927 718 666 718 718 666 604 770 770 385 500 770 666 937 718 770 
604 770 718 552 666 718 718 1000 718 718 666 322 270 322 572 500 
322 500 552 437 552 437 322 500 552 270 322 552 270 822 552 500 
552 552 437 385 322 552 500 718 500 500 437 385 218 385 510 0 
0 0 0 0 718 500 604 552 750 750 0 541 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 322 500 500 0 500 500 500 500 270 500 500 322 322 0 0 
0 500 500 500 250 0 531 343 322 500 500 500 1000 1000 0 500 
0 322 322 322 322 0 0 0 322 0 0 322 0 0 0 0 
1000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 1000 0 291 0 0 0 0 0 770 1000 322 0 0 0 0 
0 718 0 0 0 0 0 0 0 500 718 552 ]
/Encoding 76 0 R
/BaseFont /PHGHCA+AdvTT2cba4af3.B
/FontDescriptor 53 0 R
>>
endobj
10 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F7
/FirstChar 33
/LastChar 126
/Widths [1000 437 1000 385 1000 1000 218 1000 1000 1000 1000 1000 0 500 1000 1000 
1000 0 0 1000 1000 1000 1000 385 1000 1000 1000 666 1000 666 1000 385 
0 437 822 666 437 718 666 666 0 0 552 718 0 0 718 822 
0 552 666 0 718 1000 552 666 822 666 437 822 437 1000 1000 0 
552 552 666 500 437 666 500 885 333 666 552 552 552 500 666 552 
500 552 666 437 500 0 552 500 500 437 500 0 385 822 ]
/Encoding 78 0 R
/BaseFont /PHGHCC+AdvPi1
/FontDescriptor 55 0 R
>>
endobj
11 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F8
/FirstChar 32
/LastChar 254
/Widths [250 333 708 500 552 833 781 437 333 333 500 552 250 552 250 281 
500 500 500 500 500 500 500 500 500 500 281 281 552 552 552 447 
552 718 666 718 614 614 760 604 718 333 635 718 687 885 718 718 
770 739 552 593 614 687 437 770 645 791 614 333 864 333 656 500 
500 635 552 552 489 437 520 406 604 333 604 552 552 572 520 552 
552 520 552 604 437 572 708 687 489 687 489 479 197 479 552 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 625 250 552 166 708 500 750 750 750 750 1041 989 604 989 604 
395 552 406 552 552 708 489 458 552 552 552 552 1000 604 1000 656 
822 687 791 989 770 770 822 770 770 708 708 708 708 708 708 708 
770 708 791 791 885 822 552 250 708 604 604 1041 989 604 989 604 
489 333 791 791 781 708 385 385 385 385 385 385 489 489 489 489 
0 333 270 687 687 687 385 385 385 385 385 385 489 489 489 ]
/Encoding 79 0 R
/BaseFont /PHGHCE+AdvP697C
/FontDescriptor 57 0 R
>>
endobj
12 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F9
/FirstChar 33
/LastChar 251
/Widths [270 458 583 500 1000 718 270 500 500 500 1000 270 333 270 333 500 
500 500 500 500 500 500 500 500 500 333 333 1000 1000 1000 385 1000 
718 666 718 770 666 604 718 822 385 500 718 666 989 770 770 666 
770 718 604 666 770 718 989 718 718 718 500 333 500 500 500 270 
500 500 437 500 437 333 500 500 270 270 531 270 770 500 500 500 
500 385 385 333 500 437 666 552 500 437 437 270 437 500 0 604 
822 822 562 0 0 0 0 1000 1000 968 1000 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
270 437 500 114 718 500 604 822 0 500 500 333 333 552 552 0 
500 604 604 270 0 0 0 0 500 500 500 1000 0 0 385 0 
166 166 166 166 0 166 0 166 0 166 166 0 0 0 166 1000 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
989 0 333 0 0 0 0 0 770 1000 333 0 0 0 0 0 
604 0 0 0 270 0 0 0 500 604 500 ]
/Encoding 80 0 R
/BaseFont /PHGHCG+AdvTimes-i
/FontDescriptor 59 0 R
>>
endobj
21 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F10
/FirstChar 33
/LastChar 254
/Widths [270 500 958 500 822 770 270 333 333 500 656 270 333 270 500 500 
500 500 500 500 500 500 500 500 500 270 270 270 656 270 385 1000 
770 656 718 822 656 656 822 822 385 437 822 656 989 822 770 593 
770 770 541 656 822 718 989 770 770 656 270 447 270 500 114 270 
500 541 437 541 437 333 500 541 270 270 541 270 822 541 541 541 
541 385 385 333 541 500 718 500 500 437 437 270 437 291 0 0 
0 0 0 0 0 0 0 0 0 0 0 822 520 197 395 166 
333 302 541 520 260 604 656 0 0 0 0 0 500 343 687 520 
593 541 541 822 822 770 770 0 0 0 0 0 0 0 0 0 
1000 1000 385 0 0 822 541 270 385 656 500 666 385 666 437 500 
500 281 281 281 281 281 281 281 281 281 281 500 270 541 541 770 
1000 770 1000 500 770 541 656 770 333 770 822 1000 718 541 770 656 
500 500 500 500 500 500 0 0 0 0 0 0 0 0 0 500 
500 500 270 593 1000 1000 1000 1000 1000 1000 500 500 500 656 ]
/Encoding 81 0 R
/BaseFont /PHGLBA+AdvT001
/FontDescriptor 61 0 R
>>
endobj
22 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F11
/FirstChar 0
/LastChar 255
/Widths [770 270 770 500 770 500 770 770 770 770 770 770 770 1000 500 500 
770 770 770 770 770 770 770 770 770 770 770 770 1000 1000 770 770 
1000 1000 500 500 1000 1000 1000 770 1000 1000 604 604 1000 1000 1000 770 
270 1000 656 656 885 885 0 0 552 552 656 500 718 718 770 770 
604 791 645 520 770 520 708 593 843 541 666 760 687 1197 812 791 
687 812 843 604 541 625 604 979 708 666 718 656 656 656 656 656 
604 604 437 437 437 437 500 500 385 385 270 500 500 604 500 270 
822 750 822 406 656 656 770 770 437 437 437 604 770 770 770 770 
458 770 895 770 1000 385 385 770 770 270 270 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 770 
]
/BaseFont /PHGLBC+AdvP4C4E74
/FontDescriptor 63 0 R
>>
endobj
23 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F12
/FirstChar 32
/LastChar 180
/Widths [333 0 604 500 500 385 604 604 604 500 718 500 500 437 604 552 
552 510 614 447 447 447 510 447 447 510 666 510 510 447 510 510 
510 583 0 583 583 447 1000 1000 1000 1000 1000 1000 1000 1000 1000 1000 
1000 1000 1000 1000 1000 1000 1000 1000 1000 1000 0 1000 1000 1000 770 770 
770 770 770 770 770 770 770 770 1000 1000 968 968 968 968 968 968 
968 968 968 968 1000 1000 270 385 385 781 1000 1000 1000 1000 1000 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 1000 1000 1000 1000 500 500 270 437 385 791 1000 1000 1000 1000 1000 
1000 1000 1000 500 385 ]
/Encoding 82 0 R
/BaseFont /PHGLBE+AdvP40798
/FontDescriptor 65 0 R
>>
endobj
24 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F13
/FirstChar 33
/LastChar 251
/Widths [270 458 583 500 1000 770 270 333 333 500 1000 270 333 270 333 500 
500 500 500 500 500 500 500 500 500 270 270 1000 1000 1000 385 1000 
770 666 718 822 666 666 822 822 385 437 822 666 989 822 770 604 
770 770 552 666 822 718 989 770 770 666 270 333 270 500 500 270 
500 552 437 552 437 333 500 552 270 270 552 270 822 552 552 552 
552 385 385 333 552 500 718 500 500 437 437 270 437 500 0 604 
822 822 562 0 0 0 0 1000 1000 968 1000 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
270 437 500 114 770 500 385 822 0 500 500 270 270 552 552 0 
500 500 500 270 0 0 0 0 500 500 500 1000 0 0 385 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1000 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
1000 0 333 0 0 0 0 0 770 1000 333 0 0 0 0 0 
666 0 0 0 270 0 0 0 552 718 552 ]
/Encoding 80 0 R
/BaseFont /PHGLBG+AdvTimes
/FontDescriptor 67 0 R
>>
endobj
25 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F14
/FirstChar 32
/LastChar 251
/Widths [250 833 552 833 833 833 833 666 833 833 833 833 833 500 833 281 
333 833 833 833 833 833 833 833 333 333 614 666 833 666 833 333 
833 718 666 833 666 666 781 614 781 385 781 718 718 885 781 781 
781 781 666 666 666 781 781 500 718 718 614 833 281 500 833 833 
666 614 614 614 500 447 666 552 614 333 447 552 552 666 500 500 
666 666 500 614 447 500 666 614 552 447 447 333 281 1000 666 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 833 833 833 0 833 447 0 0 0 500 0 500 0 0 
833 0 833 833 0 833 0 0 0 0 0 0 0 0 0 0 
833 0 552 833 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 833 0 0 0 0 0 833 833 833 833 
833 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 833 833 0 0 0 0 833 833 833 833 552 ]
/Encoding 83 0 R
/BaseFont /PHGLBI+AdvP7DA6
/FontDescriptor 69 0 R
>>
endobj
29 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F15
/FirstChar 32
/LastChar 249
/Widths [250 1000 833 1000 1000 833 833 833 833 833 833 333 833 833 833 833 
833 833 833 833 833 833 833 833 833 833 500 500 833 833 718 833 
1000 718 718 718 781 552 552 781 781 333 552 781 552 947 781 833 
718 833 718 718 666 718 718 1000 718 718 666 666 833 833 833 833 
1000 833 833 833 833 833 833 833 833 833 833 833 833 833 833 833 
500 833 833 833 833 833 833 833 833 833 666 666 833 833 1000 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 500 500 833 0 0 0 0 0 718 0 0 0 0 0 
833 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 833 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 
0 0 0 0 0 0 0 0 833 718 ]
/Encoding 84 0 R
/BaseFont /PHGPAE+AdvP7DC6
/FontDescriptor 71 0 R
>>
endobj
30 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F17
/Encoding 85 0 R
/BaseFont /Symbol
>>
endobj
31 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F20
/FirstChar 32
/LastChar 255
/Widths [228 228 291 456 456 729 547 157 273 273 319 479 228 273 228 228 
456 456 456 456 456 456 456 456 456 456 228 228 479 479 479 456 
832 547 547 592 592 547 501 638 592 228 410 547 456 683 592 638 
547 638 592 547 501 592 547 774 547 547 501 228 228 228 385 456 
273 456 456 410 456 456 228 456 456 182 182 410 182 683 456 456 
456 456 273 410 228 456 410 592 410 410 410 274 213 274 479 0 
547 547 592 547 592 638 592 456 456 456 456 456 456 410 456 456 
456 456 228 228 228 228 456 456 456 456 456 456 456 456 456 456 
456 328 456 456 456 287 440 501 604 604 820 273 273 0 820 638 
0 479 0 0 456 456 0 0 0 0 0 303 299 0 729 501 
501 273 479 0 456 0 0 456 456 820 0 547 547 638 820 774 
456 820 273 273 182 182 479 0 410 547 137 456 273 273 410 410 
456 228 182 273 820 547 547 547 547 547 228 228 228 228 638 638 
0 638 592 592 592 228 273 273 273 273 273 273 273 273 273 273 
]
/Encoding 86 0 R
/BaseFont /Helvetica-Narrow
/FontDescriptor 73 0 R
>>
endobj
32 0 obj
<<
/Type /Font
/Subtype /Type1
/Name /F22
/Encoding 87 0 R
/BaseFont /ZapfDingbats
>>
endobj
74 0 obj
<<
/Type /Encoding
/Differences []
>>
endobj
75 0 obj
<<
/Type /Encoding
/Differences []
>>
endobj
76 0 obj
<<
/Type /Encoding
/Differences []
>>
endobj
77 0 obj
<<
/Type /Encoding
/Differences []
>>
endobj
78 0 obj
<<
/Type /Encoding
/Differences []
>>
endobj
79 0 obj
<<
/Type /Encoding
/Differences []
>>
endobj
80 0 obj
<<
/Type /Encoding
/Differences [ 128/C128
]
>>
endobj
81 0 obj
<<
/Type /Encoding
/Differences []
>>
endobj
82 0 obj
<<
/Type /Encoding
/Differences []
>>
endobj
83 0 obj
<<
/Type /Encoding
/Differences []
>>
endobj
84 0 obj
<<
/Type /Encoding
/Differences []
>>
endobj
85 0 obj
<<
/Type /Encoding
/Differences []
>>
endobj
86 0 obj
<<
/Type /Encoding
/Differences [ 0/NUL/SOH/STX/ETX/EOT/ENQ/ACK/BEL
/BS/HT/LF/VT/FF/CR/SO/SI
/DLE/DC1/DC2/DC3/DC4/NAK/SYN/ETB
/CAN/EM/SUB/ESC/FS/GS/RS/US
 39/quotesingle 96/grave 127/DEL/Adieresis/Aring/Ccedilla/Eacute/Ntilde
/Odieresis/Udieresis/aacute/agrave/acircumflex/adieresis/atilde/aring
/ccedilla/eacute/egrave/ecircumflex/edieresis/iacute/igrave/icircumflex
/idieresis/ntilde/oacute/ograve/ocircumflex/odieresis/otilde/uacute
/ugrave/ucircumflex/udieresis/dagger/degree 164/section/bullet/paragraph
/germandbls/registered/copyright/trademark/acute/dieresis/notequal/AE
/Oslash/infinity/plusminus/lessequal/greaterequal/yen/mu/partialdiff
/summation/product/pi/integral/ordfeminine/ordmasculine/Omega/ae
/oslash/questiondown/exclamdown/logicalnot/radical/florin/approxequal/Delta
/guillemotleft/guillemotright/ellipsis/nbspace/Agrave/Atilde/Otilde/OE
/oe/endash/emdash/quotedblleft/quotedblright/quoteleft/quoteright/divide
/lozenge/ydieresis/Ydieresis/fraction/currency/guilsinglleft/guilsinglright/fi
/fl/daggerdbl/periodcentered/quotesinglbase/quotedblbase/perthousand/Acircumflex/Ecircumflex
/Aacute/Edieresis/Egrave/Iacute/Icircumflex/Idieresis/Igrave/Oacute
/Ocircumflex/apple/Ograve/Uacute/Ucircumflex/Ugrave 246/circumflex/tilde
/macron/breve/dotaccent/ring/cedilla/hungarumlaut/ogonek/caron
]
>>
endobj
87 0 obj
<<
/Type /Encoding
/Differences [ 128/a89/a90/a93/a94/a91/a92/a205/a85
/a206/a86/a87/a88/a95/a96
]
>>
endobj
1 0 obj
<<
/Type /Page
/Parent 14 0 R
/Resources 3 0 R
/Contents 2 0 R
>>
endobj
15 0 obj
<<
/Type /Page
/Parent 14 0 R
/Resources 17 0 R
/Contents 16 0 R
>>
endobj
18 0 obj
<<
/Type /Page
/Parent 14 0 R
/Resources 20 0 R
/Contents 19 0 R
>>
endobj
26 0 obj
<<
/Type /Page
/Parent 14 0 R
/Resources 28 0 R
/Contents 27 0 R
>>
endobj
35 0 obj
<<
/Type /Page
/Parent 14 0 R
/Resources 37 0 R
/Contents 36 0 R
>>
endobj
38 0 obj
<<
/Type /Page
/Parent 14 0 R
/Resources 40 0 R
/Contents 39 0 R
>>
endobj
14 0 obj
<<
/Type /Pages
/Kids [1 0 R 15 0 R 18 0 R 26 0 R 35 0 R 38 0 R]
/Count 6
/MediaBox [0 0 595 842]
>>
endobj
88 0 obj
<<
/Type /Catalog
/Pages 14 0 R
>>
endobj
89 0 obj
<<
/CreationDate (D:191000124091707)
/Producer (\376\377\000A\000c\000r\000o\000b\000a\000t\000 \000D\000i\000s\000t\000i\000l\000l\000e\000r\000 \0003\000.\0000\0002)
/Creator (3B2 Total Publishing 6.03d/W)
/Title (98-1100 285..290)
>>
endobj
xref
0 90
0000000000 65535 f
0000161581 00000 n
0000000017 00000 n
0000016933 00000 n
0000144736 00000 n
0000145697 00000 n
0000146659 00000 n
0000147593 00000 n
0000148531 00000 n
0000149130 00000 n
0000150074 00000 n
0000150635 00000 n
0000151666 00000 n
0000104530 00000 n
0000162130 00000 n
0000161670 00000 n
0000017130 00000 n
0000036652 00000 n
0000161762 00000 n
0000036816 00000 n
0000061421 00000 n
0000152613 00000 n
0000153642 00000 n
0000154641 00000 n
0000155406 00000 n
0000156335 00000 n
0000161854 00000 n
0000061651 00000 n
0000077718 00000 n
0000157226 00000 n
0000158081 00000 n
0000158186 00000 n
0000159257 00000 n
0000104639 00000 n
0000104747 00000 n
0000161946 00000 n
0000077925 00000 n
0000098282 00000 n
0000162038 00000 n
0000098501 00000 n
0000104146 00000 n
0000104264 00000 n
0000104397 00000 n
0000104854 00000 n
0000105174 00000 n
0000106635 00000 n
0000107109 00000 n
0000110436 00000 n
0000110986 00000 n
0000120757 00000 n
0000121213 00000 n
0000129417 00000 n
0000129632 00000 n
0000130559 00000 n
0000131022 00000 n
0000137918 00000 n
0000138139 00000 n
0000138715 00000 n
0000138947 00000 n
0000139359 00000 n
0000139579 00000 n
0000139859 00000 n
0000140146 00000 n
0000142044 00000 n
0000142282 00000 n
0000142711 00000 n
0000142930 00000 n
0000143179 00000 n
0000143397 00000 n
0000143680 00000 n
0000143897 00000 n
0000144125 00000 n
0000144340 00000 n
0000144531 00000 n
0000159368 00000 n
0000159428 00000 n
0000159488 00000 n
0000159548 00000 n
0000159608 00000 n
0000159668 00000 n
0000159728 00000 n
0000159799 00000 n
0000159859 00000 n
0000159919 00000 n
0000159979 00000 n
0000160039 00000 n
0000160099 00000 n
0000161455 00000 n
0000162255 00000 n
0000162312 00000 n
trailer
<<
/Size 90
/Root 88 0 R
/Info 89 0 R
/ID [<037a5b32b4d11c540865a1855d3694b0><037a5b32b4d11c540865a1855d3694b0>]
>>
startxref
162573
%%EOF
1 0 obj
<< 
/Type /Page 
/Parent 14 0 R 
/Resources 3 0 R 
/Contents 2 0 R 
/Thumb 93 0 R 
>> 
endobj
15 0 obj
<< 
/Type /Page 
/Parent 14 0 R 
/Resources 17 0 R 
/Contents 16 0 R 
/Thumb 95 0 R 
>> 
endobj
18 0 obj
<< 
/Type /Page 
/Parent 14 0 R 
/Resources 20 0 R 
/Contents 19 0 R 
/Thumb 97 0 R 
>> 
endobj
26 0 obj
<< 
/Type /Page 
/Parent 14 0 R 
/Resources 28 0 R 
/Contents 27 0 R 
/Thumb 99 0 R 
>> 
endobj
35 0 obj
<< 
/Type /Page 
/Parent 14 0 R 
/Resources 37 0 R 
/Contents 36 0 R 
/Thumb 101 0 R 
>> 
endobj
38 0 obj
<< 
/Type /Page 
/Parent 14 0 R 
/Resources 40 0 R 
/Contents 39 0 R 
/Thumb 103 0 R 
>> 
endobj
89 0 obj
<< 
/CreationDate (D:191000124091707)
/Producer (\376\377\000A\000c\000r\000o\000b\000a\000t\000 \000D\000i\000s\000t\000\
i\000l\000l\000e\000r\000 \0003\000.\0000\0002)
/Creator (3B2 Total Publishing 6.03d/W)
/Title (98-1100 285..290)
/ModDate (D:20000124092145)
>> 
endobj
90 0 obj
[ 
/Indexed /DeviceRGB 255 91 0 R 
]
endobj
91 0 obj
<< /Filter [ /ASCII85Decode /LZWDecode ] /Length 92 0 R >> 
stream
J,g]g+e/h_!_gCtO=0f)$P%cIi8Zdfc5&3j_8$7g.@L`YKUJNGBP\poR=_;Dl'P(T
(7Boo^^S:71(MN]ZQX/+Cbu.lK"p74pe1T%s.DY%&\1TdJhr54.M9au6>79n6`Q:4
PbLSZTLEE(8E@'*1mg_*eTnN*;*'V3+gm-EEetX%;Bo$ur2ss*N`.-!.kG_q6GDD'
dKoL!8Ka#EV,@V!\j8ZFbp6EE<9cn=N6j<M8Q?[#7"dq'1>0nf;(&;QU6bUD')c@\
9-d\DA=cZ0Q>gIM$$;cd2O@&a;X,Nn_a<?V-PVE%?Sf]idH6WRZqHGq]Zm<uCi"]?
Stg(<gV-H9NB<SA\T=sN)Il%(BDIak7/H&mV!kmDUo4X;8;]V>P(]I1aRc(K1^ue>
gF/(+GaKo$qneLWDrQ#;5\S(\$q'4Q,85`-8;S(=Z"WSBOV*FM)4,?B],R<gbPN=#
OmIK<a:\o8+ioO-!W~>
endstream
endobj
92 0 obj
488 
endobj
93 0 obj
<< /Filter [ /ASCII85Decode /LZWDecode ] /Width 74 /Height 105 /ColorSpace 90 0 R 
/BitsPerComponent 8 /Length 94 0 R >> 
stream
J2Q7]3$]7K#D>EP:q1$o*=mro@So+\<\5,=TOSSDU'<b!O2thXknKFR*.uA/;#+(V
;$iR^k#4:9enm@9:1mM9jS"!dTMT<"M/=#f8#/Z=FLYU'SJnA)C/m<k2P4'9eSA0r
j`Z8YYXhsU$G;P>@BnKo[&MlET4YF\/N3IX!blYY>j/FS`R=E2No+R&qqOOBDmr?5
\9o>EZ\uh$/9U0*3t!U\dI<GQL-BC=U1S=gm1,$TG+%U%EdXZ5;)6[9o2.*".kS)^
AurR*^=HT!UKfb-Xp-C2_r>H?](pdJ--YNB,^fs]99Z@@7_4_rcYJdSmD_5u5/qn_
iJZXSSrW^Vg$SQ^C:M@2dasWXo=4R?-em^t^X'gd!5H[_!<=fLqpPHd:_RmT6-qG*
CVhc(%1"CS!mq%cE2m=T6?':b!^nG81AnsBjAQCNYnMg+_oP5A#0!hE8JT4lHhA.B
Z*ZS2a"e'W+ioftN?cOX9U-pGLq3W~>
endstream
endobj
94 0 obj
500 
endobj
95 0 obj
<< /Filter [ /ASCII85Decode /LZWDecode ] /Width 74 /Height 105 /ColorSpace 90 0 R 
/BitsPerComponent 8 /Length 96 0 R >> 
stream
J2Q7]3$]7K#D>EP:q1$o*=mro@So+\<\5,H7Uo;k$3i:,O@Nf$3@'nb-\]WQ;Rp>D
#;)'0V@tt+U*2@`877XLjP#"qSks"j)8nRm3MFj_'P^UmP>.=gifWG9;BJ`3^o>ga
]RlPRW7J$_Wr7sk@^AaC<k1r%cX""[Xg]3sR`fEVf^4cINQMua^L$CGRg%[9BY7[0
\(ik,'njH`/Q.NK6CX%,h''=6`c@agXQV7hN4*&rUXEe]<Es-/*N@TEobS(/b9NgP
CN^Y%IWKMD`Qk`rNW/6*:6Y$a>OGbJJ^<OM1d)nW]-l.hicocdVe`QZh/TXt*`OLe
]^PZp*_cNr2qO"5[bH:r,FMKq@;FL;[sP492"&iX^,qB3b4NLZ_Z8jc0!#h`J-hkL
#,J7)!=QdVbTdA,&*u:J6AW9="2L$<%b=%m]MTBY&R8H?`%R'V(;=dWHL8_t65pA(
OmIK<a:\n;*%:?9N?cOX9U-pGP&-[:aqBZ0.DZ8q~>
endstream
endobj
96 0 obj
511 
endobj
97 0 obj
<< /Filter [ /ASCII85Decode /LZWDecode ] /Width 74 /Height 105 /ColorSpace 90 0 R 
/BitsPerComponent 8 /Length 98 0 R >> 
stream
J2Q7]3$]7K#D>EP:q1$o*=mro@So+\<\5,H7Uo<*U'<b&O@WmO3:q5c-^753OssqM
>6C3cA^K\+ejV9^:1f[a[,uK\TMT)RC(tE*24_fu1[68%J:XUbBp1Hg66B-nc6TfT
<&V9iJQLp?)^QiOAWtOje_&LUh/Bf-WO@U2!b)/'fWCK5jeh]tQ/CYG*#9%[Ku67I
(n3qa.uUH:nTW]i:FTkTA+J;(6pinpbN:Vu9^R0sQ."T3q7EKg4/^*b23=no7q&[P
ijUrchVUc6WFf\14m*VE`7esMd#G/C$c\q4FI`:dK6tD>Ep>fjLB!=emIE5"9h1C1
h5g4M<F0hUc/e:YH2)<;0;1%bH$mA&'H2At]h:HPp:\bA$M5VsPP"(I:BUOD^i2'C
e2bkWVZ\;B<$Mc.d$-TA0oXU&$n6'mqY<Gi3XH6a;'TDt`,T$\(r2(-CA#Qf1:ZV^
d0+:s7hPA(%EC4TN?cOX9U-pGP&-[:aqBZ/W1Y7~>
endstream
endobj
98 0 obj
510 
endobj
99 0 obj
<< /Filter [ /ASCII85Decode /LZWDecode ] /Width 74 /Height 105 /ColorSpace 90 0 R 
/BitsPerComponent 8 /Length 100 0 R >> 
stream
J2Q7]3$]7K#D>EP:q1$o*=mro@So+\<\5,H7Uo;k$3i:,O@Nf$3@'nb-\]WQ;Rp>H
>q_R4V@ttcZ:k7g:/Ea7jS"!dTMT;e$'^;P.tLE`o%Hd;RinWMBsCi`&rd*reYCZn
4`6</YXPFt4!`C6%C4])<Efp@+`"Sk@J:_:f&q1g9<S#Yj[tGZ^g?LHbB=[$K=p-I
(L0unj,M)_neiC4)_DB=@kd_J<_k`!c0+G]m1dT.V4(ug<K0G68Zegm2ASH)cMb''
9_EbDNop#4hch7o*B)r7Z/P6;S.8TkG=/'!qAhbT1NanaFh%CP00?l)n9A?N*UV=d
Y4CWJf8;a*`GP0DrS4$:X'N]@be<M+PV-p5^*kJVJj<u`$AlPP,RFRAn7!UFWGh\C
Uqq!'^BqdhPVB*jW'\f2_bb.M%\W=h%0OGiHq::c0bT<E`%\Pns2Hc,`t^eB>[%u:
EC<_(7;=r/*_3J'+!AG)C`NPf;>VoJ7Yj`F(9>bc2&8U,Ul(g'WHoX8aflD*S]L81
9,biKF*TI^;cDnu_p[VST02K\JE=LD_A*>=F0oJ^4u,J[(!omliB5?/h$U=3Oj+++
]bC>j8^`j*/PFP,br&5EPjLV0e-g!m~>
endstream
endobj
100 0 obj
635 
endobj
101 0 obj
<< /Filter [ /ASCII85Decode /LZWDecode ] /Width 74 /Height 105 /ColorSpace 90 0 R 
/BitsPerComponent 8 /Length 102 0 R >> 
stream
J2Q7]3$]7K#D>EP:q1$o*=mro@So+\<\5,H7Uo<*U'<b&O@WmO3:q5c-^756a;B#V
>q_O4O<=g>dT\Dq8>:0=/@#LCL/)9d.GPa@5bLI+&ukdEO$8+mC,F"ZqNFFI60U3U
>jA?@RDC58H8S"q3j)$7[J%9Ta&oFqXqTIt;Sc;@?>#I;bT>5ILfLH64-a:^G,81*
[4G=e#CaG50K';d-M`)2A7bR!Fh]Z%Uf=[B8A4;<HbF(Y)6B&pa+M6DYn7E<1Fl)K
9O]ms?8<,'h.sDW4rq3D?-UB>'Y9>]=2;"UqGSpB-_Y[;p%U3neZZ=8O?i^V5+ZDp
2t>S6^7P(?_<CU4I"#E]8*RYXrVp.&SY+d-^+Y\ek<EjjnuBI.'E4Z<O5&=[.#R'm
pH4:3*sFq^`"*8=n,tNRUQ1!%pd&kp!gUU,1V48gDtI6<7'Qkl(W4Vd32+-E,Z=V2
Lf?#D7a[Cd+3*gbCEC)![!*P,d>SMD^60a@]#%93.Z?r[e3<cJ:CMq1UT%dEW_"pu
SLD_N>ghZU1?;ps_bmeq33uKSf"+HcjGbiJ&u0KY:K%p2*C]Rim4-)8"VSU4F:A15
:U>D2Pdq>G-UUJq%.><:;=,N!;m[8k7_]Wgo.rH!`.Lk9Q#0f.eeO0U=k8k?D-PU,
c#i1m+9~>
endstream
endobj
102 0 obj
679 
endobj
103 0 obj
<< /Filter [ /ASCII85Decode /LZWDecode ] /Width 74 /Height 105 /ColorSpace 90 0 R 
/BitsPerComponent 8 /Length 104 0 R >> 
stream
J2Q7]3$]7K#D>EP:q1$o*=mro@So+\<\5,H7Uo;k$3i:,O@Nf$3@'nb-\k6(;Rp=m
$S@`>+u76X`bd2ic/qp7I'ul'SPGi")<B4q7uG\@e(Rdt+\e(ckB&,#6C.bS9W@]Q
`"KUdUf_DTqMbuS5b;*BFaH!'boiJ.-.(D3K!BI-?=B1&om5^4V-5;"/&eOo1W&#8
o,;2'ooFc50t;KM9(/(Gg`r2TQ1E+bQWeDJ4XQLiVpoI(>.nOW?*DmsG$@,,f58"P
DKf<uk4a;=i,EpG4sq/+a5h8d>eXi0S^6MAH<i_4=0:*@G'dN/kBFVsn9B=e5:;fBiIHF~>
endstream
endobj
104 0 obj
339 
endobj
xref
0 2 
0000000000 65535 f
0000164542 00000 n
15 1 
0000164644 00000 n
18 1 
0000164749 00000 n
26 1 
0000164854 00000 n
35 1 
0000164959 00000 n
38 1 
0000165065 00000 n
89 16 
0000165171 00000 n
0000165456 00000 n
0000165509 00000 n
0000166092 00000 n
0000166113 00000 n
0000166770 00000 n
0000166791 00000 n
0000167459 00000 n
0000167480 00000 n
0000168147 00000 n
0000168168 00000 n
0000168961 00000 n
0000168983 00000 n
0000169821 00000 n
0000169843 00000 n
0000170341 00000 n
trailer
<<
/Size 105
/Info 89 0 R 
/Root 88 0 R 
/Prev 162573 
/ID[<037a5b32b4d11c540865a1855d3694b0><4ae67debf7356a72a92f28dbfb1403d2>]
>>
startxref
170363
%%EOF