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0 g
/GS2 gs
1 i 
391.011 616.762 0.51 -274.507 re
f
BT
/F1 1 Tf
14.944 0 0 14.944 96.151 712.403 Tm
0.0209 Tc
[(Development)-332.8(of)-332.8(tuberculin)-336.3(reactivity)-330(a)0.1(nd)-332.5(sensitization)]TJ
1.3847 -1.0357 TD
0.0198 Tc
(to)Tj
/F2 1 Tf
1.3202 0 TD
0.0208 Tc
[(M.)-335.5(Scrofulaceum)]TJ
/F1 1 Tf
8.6724 0 TD
0.0221 Tc
(and)Tj
/F2 1 Tf
2.1776 0 TD
0.021 Tc
[(M.)-331.5(Fortuitum)]TJ
/F1 1 Tf
6.6845 0 TD
0.0205 Tc
[(in)-332.9(children)]TJ
-12.7241 -1.0319 TD
0.0207 Tc
[(BCG-vaccinated)-336.5(a)-0.1(t)-333(b)1.2(irth)]TJ
/F3 1 Tf
10.959 0 0 10.959 129.373 644.145 Tm
0 Tc
[(L.)-331(Kro)]TJ
2.2658 0 TD
[(\310)-117.1(ger)]TJ
/F4 1 Tf
1.883 0 TD
0 Tw
(*)Tj
/F3 1 Tf
0.5018 0 TD
[(,)-329.4(M)0(.)-334.5(Korppi)]TJ
/F4 1 Tf
4.93 0 TD
(*)Tj
/F3 1 Tf
0.4966 0 TD
[(,)-334.6(J)0(.)-331.2(Pelkonen)]TJ
/F4 1 Tf
5.8716 0 TD
(**)Tj
/F3 1 Tf
0.9984 0 TD
[(,)-329.4(M)0(.)-334.5(Pietika)]TJ
4.5989 0 TD
[(\310)-111.9(inen)]TJ
/F4 1 Tf
8.219 0 0 7.305 390.898 649.02 Tm
(+)Tj
/F3 1 Tf
10.959 0 0 10.959 395.546 644.145 Tm
[(,)-329.4(M.L.)-334.4(Katila)]TJ
/F4 1 Tf
5.3749 0 TD
(**)Tj
/F5 1 Tf
8.966 0 0 8.966 58.28 607.294 Tm
[(Development)-586.5(of)-576.8(tuber)30.8(culin)-583.7(r)30.9(eactivity)-585.7(and)-580.2(sensitization)-584(to)]TJ
/F4 1 Tf
25.0008 0 TD
[(M.)-584.8(Scrofulaceum)]TJ
/F5 1 Tf
7.7835 0 TD
(and)Tj
/F4 1 Tf
2.0802 0 TD
(M.)Tj
-34.8645 -1.0559 TD
(Fortuitum)Tj
/F5 1 Tf
4.3565 0 TD
[(in)-406(childr)28.9(en)-403.4(BCG-vaccinated)-401.2(at)-406(birth.)-404.7(L.)-399.3(Kr)33(o)]TJ
17.9191 -0.0253 TD
(\310)Tj
0.4047 0.0253 TD
[(ger)101.7(,)-401.3(M)0(.)-401.2(Korppi,)-406.5(J.)-400.5(Pelkonen,)-402.3(M.)]TJ
-22.6803 -1.0559 TD
(Pietika)Tj
2.3837 -0.0253 TD
(\310)Tj
0.4047 0.0253 TD
[(inen,)-338.1(M.L.)-332.6(Katila.)]TJ
/F6 1 Tf
7.5622 0 TD
(#)Tj
/F5 1 Tf
0.999 0 TD
[(ERS)-334.2(Journals)-335.6(Ltd)-334.6(2000.)]TJ
/F7 1 Tf
-11.3496 -1.0559 TD
[(ABSTRACT)66.7(:)-310.3(Since)-312.7(the)-313.9(incidence)-317.5(of)-309.8(tuberculosis)-306.9(is)-312.4(steadily)-317.4(declining)-314(in)-316.1(Finland)-310.3(and)]TJ
T*
[(infections)-322(by)-313.7(environmental)-310.7(mycobacteria)-324.1(may)-315.1(be)-319.8(increasing,)-310.1(the)-313.9(aim)-317.5(of)-322.4(the)-313.9(present)]TJ
T*
[(study)-382.5(was)-388.7(to)-385.7(evaluate)-383.1(the)-383.5(development)-391.6(of)-385.7(tuber)11.2(culin)-384.9(reactivity)-380.3(and)-381.3(sensitization)-393.6(to)]TJ
T*
[(environ)10.8(mental)-340.5(mycobacteria.)]TJ
0.999 -1.0559 TD
[(Healthy)-607(Finnish)-602.3(schoolchildr)9(en)-604.4(aged)-597(10.4\26112.4)-602.9(yrs)-600.1(\(n)]TJ
/F8 1 Tf
24.4823 0 TD
(=)Tj
/F7 1 Tf
0.5501 0 TD
[(201\))-599.6(were)-594.9(tested)-605.2(with)]TJ
-26.0314 -1.0559 TD
[(tuber)11.2(culin)-321.6(purified)-319.4(protein)-306.3(derivative)-321(R)35.1(T23,)]TJ
/F9 1 Tf
19.2406 0 TD
[(Mycobacterium)-322(scrofulaceum)]TJ
/F7 1 Tf
12.5699 0 TD
[(RS95)-316(and)]TJ
/F9 1 Tf
-31.8106 -1.0559 TD
[(M.)-331.9(fortuitum)]TJ
/F7 1 Tf
5.6906 0 TD
[(RS20)-335(sensitins.)-333.3(The)-330.3(same)-334.5(children)-324.5(had)-330.8(been)-329.8(previously)-326.4(tested)-333.3(with)-332(the)]TJ
-5.6906 -1.0559 TD
[(same)-265(antigens)-269.3(and)-267.5(methods)-267.9(at)-265.5(the)-263.4(age)-270.1(of)-265.5(4\2616)-264(yrs)-265(in)-271.8(1989.)-260.1(Rapid)-272.2(waning)-265.3(of)-265.5(tuber)11.2(culin)]TJ
T*
[(reactivity)-247.5(and)-248.6(decre)11.2(ase)-252.4(in)-252.9(sensitization)-254.5(to)-252.9(environ)10.8(mental)-252(mycobacteria)-254.6(were)-240.8(observed)]TJ
T*
[(between)-338.6(4\2616)-327.3(yrs.)]TJ
0.999 -1.0559 TD
[(Both)-305.7(tuberculin)-297.8(and)-305.5(sensitin)-310.8(skin)-302.2(reaction)-294.4(sizes)-311.6(decre)11.2(ased)-307.4(significantly)-306.5(over)-307.3(the)-307.6(6-)]TJ
-0.999 -1.0559 TD
[(yrs)-227.1(period.)-232.9(The)-229.2(mean)-224.4(tuberculin)-221.9(skin)-232.7(r)13.4(eaction)-231.9(size)-228.7(was)-230.6(3.2)-229.5(mm)-227.6(in)-227.6(diameter)78.2(,)-230.5(which)-227.7(was)]TJ
T*
[(significantly)-230.6(\(p)]TJ
/F8 1 Tf
6.2597 0 TD
(<)Tj
/F7 1 Tf
0.5501 0 TD
[(0.001\))-228.9(smaller)-230(than)-230.1(the)-231.7(mean)-224.4(induration)-235(size)-228.7(\(4.8)-230(mm\))-228(at)-227.6(the)-231.8(age)-225.9(of)-233.9(4\261)]TJ
-6.8098 -1.0559 TD
[(6)-378.9(yrs.)-381.7(Similarly)46.8(,)-382.3(the)-377.2(mean)-382.5(skin)-384.4(r)13.4(eaction)-383.6(sizes)-381.1(to)]TJ
/F9 1 Tf
21.1565 0 TD
[(M.)-382.5(scrofulaceum)]TJ
/F7 1 Tf
7.4484 0 TD
(and)Tj
/F9 1 Tf
1.9854 0 TD
[(M.)-382.5(fortuitum)]TJ
/F7 1 Tf
-30.5902 -1.0559 TD
[(sensitins)-223(wer)11.3(e)-220.6(3.4)-223.2(and)-216.9(1.7)-216.9(mm,)-224.1(r)13.4(espectively)45.3(,)-217.9(which)-221.4(wer)11.3(e)-220.6(significantly)-224.3(\(p)]TJ
/F8 1 Tf
29.5343 0 TD
(<)Tj
/F7 1 Tf
0.5501 0 TD
[(0.001\))-222.6(smaller)]TJ
-30.0844 -1.0496 TD
[(than)-230(6)-227.1(yrs)-233.4(earlier)-227.9(\(mean)-231.2(4.5)-229.5(and)-229.6(3.1)-229.5(mm\).)-230.9(The)-229.2(number)-220.3(of)-227.6(zero)-218.6(reactions)-225.5(to)-227.6(all)-230.9(antigens)]TJ
0 -1.0559 TD
[(increased)-526.4(significantly)-540.4(during)-532.3(the)-535.3(follow-up)-540(period.)-536.4(Contacts)-531.8(with)-540.6(pets)-535.9(or)-529.9(farm)]TJ
T*
[(animals)-387.1(were)-380(associated)-384.5(with)-388.9(larger)-390.7(r)13.4(eactions.)-393.5(In)-384.5(contrast,)-385.8(children)-381.5(suffering)-389.6(fr)12.9(om)]TJ
T*
[(allergic)-337.5(symptoms)-333.9(had)-330.8(smaller)-337.5(reactions.)]TJ
0.999 -1.0559 TD
[(Contacts)-411.7(with)-414.2(mycobacteria,)-409.2(either)-415.5(with)]TJ
/F9 1 Tf
17.9444 0 TD
[(Mycobacterium)-410.5(tuberculosis)]TJ
/F7 1 Tf
12.1463 0 TD
[(or)-409.8(environ-)]TJ
-31.0898 -1.0559 TD
[(mental)-239.4(mycobacteria,)-232.2(seem)-239.5(to)-233.9(be)-237.6(too)-233.4(rar)14.6(e)-239.6(t)0(o)-233.9(maintain)-233.2(tuberculin)-228.2(respons)10.8(iveness)-239.6(and)-235.9(a)]TJ
T*
[(high)-503.4(sensitivity)-503.7(to)-499.5(other)-502.4(mycobacteria.)-504.1(Different)-495.1(bacille)-507.5(Calmette-Gue)]TJ
30.7293 0.0379 TD
(\302)Tj
0.3731 -0.0379 TD
[(rin)-505.1(vaccine)]TJ
-31.1024 -1.0559 TD
[(products)-309.5(and)-311.8(dosages)-313.3(used,)-321.5(the)-313.9(declining)-320.3(incidence)-317.5(of)-316.1(tuber)11.2(culosis)-318.1(and)-318.1(geographical)]TJ
T*
[(factors,)-292.9(which)-290.9(can)-287.7(influence)-293.4(environ)10.8(mental)-290(mycobacterial)-294.4(exposure,)-281(may)-289.8(explain)-289(the)]TJ
T*
[(disparity)-334.4(between)-338.6(the)-332.9(presen)11.7(t)-335.6(and)-330.8(previous)-325(Finnish)-336.7(studies.)]TJ
/F5 1 Tf
T*
[(Eur)-331.9(Respir)-333.8(J)-334.4(2000;)-333.5(15:)-334.6(382\261387.)]TJ
/F4 1 Tf
7.97 0 0 7.97 401.499 608.258 Tm
[(*Dept)-462.8(of)-465.5(Paediatri)9.7(cs,)-464.4(Kuopio)-461.7(University)]TJ
0 -1.0599 TD
[(Hospital,)-639.3(Kuopio,)-645.6(Finland)13.2(.)-653.4(**Depts)-637.6(of)]TJ
0 -1.067 TD
[(Clinical)-301.3(Microbiolog)10.6(y)59(,)-304.8(Kuopio)-298.1(University)]TJ
0 -1.0599 TD
[(and)-412.4(Kuopio)-411.9(University)-408.7(Hospital;)]TJ
5.977 0 0 5.313 511.994 586.431 Tm
(+)Tj
7.97 0 0 7.97 515.395 582.86 Tm
(Public)Tj
-14.2903 -1.0599 TD
[(Health)-326.9(Centre,)-325.9(Sillinja)]TJ
8.6353 0 TD
[(\310)-47.9(rvi,)-329.5(Finland.)]TJ
-8.6353 -2.1268 TD
[(Corresponde)11.8(nce:)-333.4(L.)-326.7(Kro)]TJ
9.3467 0 TD
[(\310)-83.5(ger)]TJ
-9.3467 -1.0599 TD
[(Dept)-329.8(of)-330.3(Paediatrics)]TJ
0 -1.067 TD
[(Kuopio)-326.6(University)-323.3(Hospital)]TJ
0 -1.0599 TD
[(FIN-70)-329.5(21)39.8(1)-332.2(Kuopio)]TJ
0 -1.067 TD
(Finland)Tj
0 -1.0599 TD
[(Fax:)-325.1(35)-330.1(817172410)]TJ
0 -2.1268 TD
[(Keywords)11.5(:)-334.6(Bacille)-328.4(Calmette-Gue)]TJ
12.9459 0.0427 TD
(\302)Tj
0.3699 -0.0427 TD
(rin)Tj
-13.3158 -1.0599 TD
(children)Tj
T*
[(environme)11(ntal)-329.7(mycobacteria)]TJ
0 -1.067 TD
(sensitin)Tj
0 -1.0599 TD
(tuberculin)Tj
0 -2.1268 TD
[(Received:)-327.9(Februar)11.5(y)-332.2(2)0(2)-330.1(1999)]TJ
0 -1.0599 TD
[(Accepted)-275.6(after)-281.8(revision)-272.8(September)-270.3(6)-282.4(1999)]TJ
0 -2.1268 TD
[(This)-374.9(study)-377.2(was)-380.5(supported)-375(by)-379.9(the)-379.2(Finnish)]TJ
0 -1.0599 TD
[(Lung)-662.9(and)-668.4(Health)-661.3(Association)-662.6(and)-668.4(the)]TJ
0 -1.067 TD
[(Maud)-324(Kuistila)-329.7(Foundation)12.4(.)]TJ
9.963 0 0 9.963 68.258 316.063 Tm
[(As)-376.5(a)-382.4(r)0(e)19.2(s)0(u)14.4(l)0(t)-370.5(o)0(f)-373(e)0(f)24.9(f)0(e)19.2(c)0(t)12.8(i)13.9(ve)-377.5(tu)18.9(be)15.1(rc)19.2(ul)18.9(os)14.4(i)13.9(s)-383.2(co)15.1(nt)18.9(ro)13.9(l)-378.7(m)0(e)17.7(a)0(s)13.9(u)0(r)19.6(e)0(s)13.9(,)]TJ
-1.0015 -1.0755 TD
[(th)18.9(e)-376.7(i)0(n)18.9(c)0(i)18.5(d)0(e)15.1(n)0(c)20.8(e)-376.7(of)-361.6(pu)15.5(lm)15.7(on)21.2(ar)13.5(y)-370.7(t)0(u)18.9(b)0(e)15.1(r)0(c)19.2(u)0(l)13.2(o)0(s)20(i)0(s)-363.6(h)0(a)15.1(s)-371.8(st)17.7(ea)14.7(di)18.9(ly)-362.4(de)15.1(-)]TJ
T*
[(cl)18.4(in)18.9(ed)-263.7(in)-265.7(Fi)19.6(nl)13.2(an)20.8(d.)-262.9(In)-264.9(19)15.5(96)21.2(,)-273.5(i)0(t)-262.4(w)0(a)16.9(s)-275.1(es)19.6(ti)16.5(ma)17.7(te)18.4(d)-273.9(t)0(o)-265.7(b)0(e)-263.7(o)0(n)21.2(l)0(y)-265.7(8)0(.)15.9(4)]TJ
T*
[(pe)15.1(r)-332.4(1)0(0)15.5(0)0(,)21.6(0)0(0)15.5(0)-336.5(po)21.2(pu)15.5(la)18.4(ti)16.5(on)-325.9([1)19.6(].)-344.2(In)-350.2(contrast)-350.2(to)-351(in)-345.3(many)-348(other)]TJ
T*
[(parts)-430.5(of)-429.9(the)-426.2(wor)-7.8(ld,)-425.4(the)-431.9(new)-427.7(cases)-428.5(of)-429.9(tuber)-8.2(culosis)-428.3(h)-6.5(ave)]TJ
T*
[(been)-487.6(concent)-8.9(rated)-492.3(in)-487.6(the)-488.8(oldest,)-489.3(non-bac)-7.7(ille)-494.3(Calmette-)]TJ
T*
(Gue)Tj
1.2861 0.0455 TD
(\302)Tj
0.3756 -0.0455 TD
[(rin)-279.4(\(B)-7.8(CG\)-vaccin)-11.7(ated,)-285.5(age)-281.9(groups)-286.2([1,)-282.3(2].)-282.3(In)-282(ad)-7.6(dition,)]TJ
-1.6616 -1.0698 TD
[(the)-255.5(incidenc)-12.1(e)-251.6(o)0(f)-253.5(human)-257.7(immunod)-8.3(eficiency)-265.2(virus)-253.7(\(HI)-9.4(V\))-251.7(is)]TJ
0 -1.0755 TD
[(low)-441.1(and)-440.9(HIV)-387.3(infec)-8.6(tions)-442.2(have)-442(been)-442(very)-443.2(rare)-439.5(in)-436.4(y)-6.5(oung)]TJ
T*
[(infan)-8.2(ts)-221.3(an)-7.6(d)-222.7(children)-229.5(\(no)-231.5(reported)-228.7(cases)-229.3(in)-225.8(199)-8(6\))-225.1([1].)-227.8(Since)]TJ
T*
[(the)-244.1(1950s,)-244.4(BCG)-249(vaccin)-8.2(ation)-248(has)-242.9(been)-242.9(routi)-10.2(nely)-244.8(offered)-238.6(to)]TJ
T*
[(all)-491.2(newb)-7.4(orn)-493.3(babies,)-493(and)-492.1(the)-494.5(vaccin)-8.2(ation)-492.7(coverag)-8.1(e)-490.6(has)]TJ
T*
[(been)-339.6(invariabl)-10.7(y)-330.8(close)-338.2(to)-339.7(100%)-335.5([3].)]TJ
1.0015 -1.0528 TD
[(En)17.1(vi)18.9(ro)13.9(nm)18.1(en)20.8(ta)12.8(l)-350.3(m)0(y)18.1(c)0(o)15.1(b)0(a)20.8(c)0(t)18.4(e)0(r)13.5(i)0(a)18.4(,)-353.2(t)13.9(h)0(o)15.5(u)0(g)15.5(h)-347.9(lo)18.9(w)-351.8(i)0(n)-345.3(v)0(i)18.9(r)0(u)13.9(l)0(e)18.4(n)0(c)20.8(e)0(,)]TJ
-1.0015 -1.0698 TD
[(ma)17.7(y)-222.7(c)0(a)14.7(u)0(s)20(e)-223.1(su)14.3(pp)21.2(ur)13.9(at)18.5(iv)18.9(e)-223.1(c)0(e)20.4(r)0(v)13.9(i)0(c)18.4(a)0(l)-214.9(a)0(d)15.1(e)0(n)20.8(i)0(t)16.5(i)0(s)-215.7(i)0(n)-214.5(h)0(e)20.8(a)0(l)18.5(t)0(h)13.2(y)-222.7(ch)20.8(il)16.5(dr)19.6(en)]TJ
0 -1.0755 TD
[(at)-414(an)-411.7(ea)20.4(rl)17.3(y)-421.9(a)0(g)20.8(e)-422.3([4)19.6(].)-435.2(Althoug)-8.3(h)-427.6(these)-435(infec)-8.6(tions)-436.6(are)-431.5(rare,)]TJ
T*
[(there)-452.5(is)-443.3(eviden)-7.8(ce)-446.2(sugges)-7.4(ting)-446(that)-446.4(thei)-8.2(r)-440.5(inci)-8.2(dence)-448.9(is)-443.3(in-)]TJ
T*
[(creasi)-11(ng)-291.7(throu)-7.8(ghout)-296.4(the)-295.3(wor)-7.8(ld)-294.1([5\2617].)-297.6(Se)-6.8(nsitization)-306.8(to)-294.1(en-)]TJ
T*
[(viron)-7.8(mental)-377.5(mycob)-7.4(acteria)-377.5(in)-373.8(non-BCG)-8.9(-vaccina)-11.7(ted)-369.3(chil)-8.2(d)]TJ
T*
[(popula)-7.4(tions)-419.5(meas)-8.2(ured)-420.5(by)-416.9(skin)-422(testing)-423.8(seems)-419.9(also)-422.4(to)-419.3(be)]TJ
25.1977 20.4006 TD
[(incre)-8.6(asing)-366.3([8].)-364.4(The)-6.8(se)-361.6(data)-364.7(indi)-7.8(cate)-365.2(an)-360.4(incre)-8.6(ase)-362.8(in)-362.4(envir-)]TJ
0 -1.0755 TD
[(onmen)-7.4(tal)-280.6(exposure)-277.2(to)-277.1(mycob)-7.4(acteria)-280.8([8,)-276.6(9].)-271(Al)-7.8(though)-274.4(pre-)]TJ
T*
[(vious)-348.8(studies)-342.9(have)-345.3(sugges)-7.4(ted)-340.8(that)-344(sensiti)-9.6(zation)-345.9(increases)]TJ
T*
[(wi)-7.8(th)-299.8(age,)-305.1(the)-306.7(incidence)-309.2(of)-304.7(mycob)-7.4(acter)-9(ioses)-304.9(due)-304.3(to)-299.8(env)-8.4(ir)11.6(-)]TJ
T*
[(onmen)-7.4(tal)-240.8(mycob)-7.4(acteria)-240.9(in)-237.2(children)-240.9(is)-238.4(highes)-8.6(t)-230.8(a)0(t)-237.6(the)-238.4(age)-236.4(of)]TJ
T*
[(1\2616)-440.5(yrs)-437.6([4,)-436(10,)-434.4(1)27.7(1].)-436(There)-437.1(is)-437.6(also)-439.5(eviden)-7.8(ce)-434.8(that)-440.7(sensi-)]TJ
T*
[(tiza)-8.6(tion)-520(may)-523.7(vary)-522.9(accordi)-10.5(ng)-519.4(to)-516.1(geograp)-7.7(hical)-527.2(location,)]TJ
0 -1.0698 TD
[(eve)-8.8(n)-330.8(withi)-9.2(n)-330.8(a)-336.9(small)-337.7(countr)-9(y)-336.5([12\26114].)]TJ
1.0015 -1.0528 TD
[(In)-378.7(an)-371.8(ea)20.4(rl)17.3(ie)12.8(r)-377.9(c)0(r)13.5(o)0(s)20(s)0(-)18.4(s)0(e)14(c)0(t)18.5(i)0(o)18.9(n)0(a)15.1(l)-378.7(st)17.7(ud)15.5(y)73.2(,)-381.7(a)-382.4(r)0(a)19.2(p)0(i)13.2(d)-382(de)20.8(cr)19.2(ea)14.7(se)-373(in)]TJ
-1.0015 -1.0755 TD
[(tu)13.2(be)20.8(rc)13.5(ul)18.9(in)-225.8(re)19.2(ac)14.7(ti)16.5(vi)18.9(ty)-225.8(oc)15.1(cu)20.8(rr)18(in)18.9(g)-239.8(b)0(e)20.8(t)0(w)14.9(e)0(e)20.4(n)-239.8(th)18.8(e)-234.5(a)0(g)15.1(e)0(s)-225.1(o)0(f)-225.1(4)-234.1(an)15.1(d)-234.1(6)]TJ
T*
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-17.4245 -1.0471 TD
[(M.)-333.6(fortuitum)]TJ
/F4 1 Tf
5.4288 0 TD
[(was)-332.2(included)-336(as)-327.5(a)-331.2(repres)-9.8(entative)-338.8(of)-327.5(rapid)-8.2(ly)]TJ
-5.4288 -1.0527 TD
[(growing)-383.1(speci)-8.2(es)-378.7(commonl)-8.7(y)-376.3(presen)-8.2(t)-373(i)0(n)-379.5(the)-375(en)-7.6(vironment)-11.1(,)]TJ
0 -1.0471 TD
[(that)-275.7(are)-277.8(potent)-9.7(ially)-273.1(pa)-7.6(thogenic)-279.1(to)-271.4(man)-279([20].)-279.8(The)-274.3(sensiti)-9.6(ns)]TJ
0 -1.0528 TD
[(\(0.1)-453.8(mL\))-449.3(wer)-8.2(e)-450.7(used)-448.5(at)-453.9(a)-450.7(dilution)-453.8(of)-452.7(1)]TJ
/F8 1 Tf
16.6221 0 TD
0 Tw
(m)Tj
/F4 1 Tf
0.5747 0 TD
(g)Tj
/F10 1 Tf
0.5008 0.1992 TD
(.)Tj
/F4 1 Tf
0.2675 -0.1992 TD
(mL)Tj
7.472 0 0 6.641 250.979 316.233 Tm
(-1)Tj
9.963 0 0 9.963 261.638 311.811 Tm
[(and)-452.3(2)]TJ
-20.412 -1.0471 TD
[(tuber)-8.2(culin)-458.5(units)-459.3(\(TU\))-458.2(tuber)-8.2(culin)-458.5(PPD)-459.9(R)51.4(T)-454.4(23)-456.8(were)-458.9(ad-)]TJ
0 -1.0528 TD
[(minist)-10.4(ered.)-318.8(The)-314.1(antigens)-320.2(wer)-8.2(e)-314.2(obtained)-319(from)-316.7(the)-318.1(State)-8.6(ns)]TJ
0 -1.0471 TD
[(Serum)-497.6(Institut)-496.4(\(Copenhag)-8.3(en,)-491.7(Denmark\))-11.5(.)-489.8(The)-490.5(Mant)-7.8(oux)]TJ
0 -1.0527 TD
[(techni)-10.1(que)-327.1(was)-326.5(perfor)-9.8(med)-330.2(according)-330.7(to)-328.3(the)-329.4(W)72(orld)-331.4(Health)]TJ
0 -1.0471 TD
[(Organization)-489.7(\(WHO\))-494(recommend)-10.3(atio)-8.2(ns)-480.7([21].)-490.3(All)-489(three)]TJ
0 -1.0527 TD
[(injectio)-10.7(ns)-435.2(were)-436.2(perfor)-9.8(med)-438.3(concom)-8.5(itantly)-436.4(on)-434(the)-437.6(dorsal)]TJ
0 -1.0471 TD
[(aspect)-9.4(s)-366.2(o)0(f)-373(the)-369.3(forear)-10.2(ms,)-370.4(two)-372.8(on)-371.4(the)-369.3(left)-374(and)-366.9(o)-6.5(n)0(e)-366.1(o)0(n)-371.4(the)]TJ
0 -1.0527 TD
[(right.)-471.5(All)-466.2(test)-470.3(injections)-474.4(as)-464.1(well)-467.4(as)-464.1(the)-471.7(reading)-471.1(of)-464.1(the)]TJ
0 -1.0471 TD
[(react)-9(ions)-365.1(after)-363(3)-365(days)-363.1(were)-367.9(performed)-368.4(by)-365.7(the)-363.6(same)-366.7(per-)]TJ
0 -1.0528 TD
[(sonnel)-264.6(as)-253.5(in)-260(the)-255.5(p)-6.5(revious)-261.3(study)55.2(.)-250.8(The)-262.9(skin)-257(test)-259.8(resul)-9.4(ts)-255.5(wer)-8.2(e)]TJ
0 -1.0471 TD
[(meas)-8.2(ured)-500.1(by)-502.3(record)-8.6(ing)-499.8(the)-505.8(transverse)-511.9(diameter)-506.2(of)-503.9(the)]TJ
0 -1.0528 TD
[(indur)-7.8(ation)-390.2(in)-385.2(millimet)-13.3(res.)-387.1(The)-388.1(test)-390.7(antigens)-394.1(were)-385(co)-7.6(ded)]TJ
0 -1.0471 TD
[(and)-423.8(the)-426.2(code)-425(was)-428.9(broken)-427.7(after)-425.6(meas)-8.2(uring)-428.9(the)-426.2(skin)-422(test)]TJ
0 -1.0527 TD
(results.)Tj
/F5 1 Tf
0 -2.5038 TD
[(Questi)-9.2(onnair)26(e)]TJ
/F4 1 Tf
1.0015 -1.7527 TD
[(Th)17.1(e)-371.1(p)0(a)15.1(r)0(e)19.2(n)0(t)13.2(s)-371.8(fi)17.3(ll)16.5(ed)-366.1(in)-362.4(a)-376.7(q)0(u)21.2(e)0(s)13.9(t)13.9(i)0(o)13.2(n)0(n)21.2(a)0(i)18.4(r)0(e)13.5(,)-370.3(wh)17.3(ic)12.8(h)-370.7(c)0(o)15.1(n)0(t)18.9(a)0(i)18.4(n)0(e)15.1(d)]TJ
-1.0015 -1.0471 TD
[(qu)15.5(es)19.6(ti)16.5(on)21.2(s)-406(a)0(b)20.8(o)0(u)15.5(t)-401.5(co)15.1(nt)18.9(ac)20.4(ts)-397.7(wi)20.6(th)-396.6(pe)20.8(rs)12.8(on)21.2(s)-406(w)12.4(it)16.5(h)-404.8(t)0(u)18.9(b)0(e)15.1(r)0(c)19.2(u)0(l)18.9(o)0(s)14.4(i)0(s)17.7(,)]TJ
25.1977 66.1583 TD
[(pr)13.9(ev)20.8(io)13.2(us)-292.9(tu)18.9(be)15.1(rc)19.2(ul)18.9(in)-294.1(te)18.4(st)17.7(in)13.2(g,)-291.4(ch)15.1(ro)19.6(ni)18.9(c)-302.8(d)0(i)13.2(s)0(e)19.6(a)0(s)19.6(e)0(s)-299(s)0(u)20(c)0(h)-292.2(a)0(s)-299(a)0(s)19.6(t)0(h)18.8(-)]TJ
0 -1.0471 TD
[(ma)-346.5(or)-344.6(al)18.5(le)18.4(r)20.4(g)0(i)18.9(e)0(s)14(,)-347.5(lo)13.2(ng)21.2(-t)17.3(er)13.5(m)-351(m)0(e)17.7(d)0(i)18.9(c)0(a)14.7(t)0(i)16.5(o)0(n)21.2(s)-354.8(an)20.8(d)-353.6(c)0(o)20.8(n)0(t)18.8(a)0(c)14.7(t)0(s)-340.8(w)0(i)14.9(t)0(h)]TJ
0 -1.0528 TD
[(pe)15.1(ts)-352.2(an)15.1(d)-359.3(f)0(a)13.5(r)0(m)-353.4(a)0(n)15.1(i)13.9(ma)12(ls)17.7(.)-358.9(R)0(e)16.1(c)0(e)14.7(n)0(t)-351(u)0(s)14.4(e)-359.7(of)-355.9(an)20.8(ti)16.5(hi)18.9(st)17.7(am)12(in)18.8(es)-350.2(an)15.1(d)]TJ
0 -1.0471 TD
[(to)13.2(pi)18.9(ca)20.4(l)-378.7(c)0(o)15.1(r)0(t)17.3(i)0(c)18.4(o)0(s)20(t)0(e)18.4(r)0(o)13.9(i)0(d)18.9(s)-377.5(we)16.9(re)-367.7(al)18.5(so)-366.9(re)13.5(co)20.8(rd)19.6(ed)15.1(.)-376(T)0(h)17.1(e)-376.8(qu)21.2(es)14(ti)16.5(on)21.2(-)]TJ
0 -1.0528 TD
[(na)15.1(ir)17.3(e)-297.1(w)12.4(as)-287.7(ch)15.1(ec)20.4(ke)15.1(d)-291(b)0(y)-286.1(t)0(h)18.9(e)-297.1(te)18.4(st)-283.9(pe)15.1(rs)18.4(on)15.5(ne)20.8(l)-299.1(a)0(t)-283.2(t)0(h)18.8(e)-297.1(ti)16.5(me)-283.9(of)-287.7(th)18.9(e)]TJ
0 -1.0471 TD
[(te)12.8(st)17.7(in)18.9(g.)]TJ
/F5 1 Tf
0 -3.1583 TD
[(Stat)-7.8(istical)-340.8(methods)]TJ
/F4 1 Tf
1.0015 -2.0998 TD
[(St)14(at)18.5(is)17.7(ti)16.5(ca)14.7(l)-270.6(a)0(n)15.1(a)0(l)18.4(y)0(s)14.4(i)13.9(s)-275.1(w)0(a)11.2(s)-275.1(pe)20.8(rf)18(or)14(me)17.7(d)-273.9(u)0(s)14.4(i)0(n)18.9(g)-273.9(S)11.4(P)0(S)17.1(S)-278.8(fo)19.6(r)-275.5(W)37.9(in)18.8(-)]TJ
-1.0015 -1.0471 TD
[(do)15.5(ws)-296.9(8.)21.6(01)-297.4(so)20(ft)17.3(wa)16.9(re)-299.4(\(S)20.4(PS)17.1(S,)-296.3(C)11.6(h)0(i)13.2(c)0(a)20.4(g)0(o)15.5(,)-302(IL)15.5(,)-302(U)0(S)18.1(A)0(\))15.7(.)-302(Th)17.1(e)-302.8(n)0(o)15.5(n)0(-)]TJ
0 -1.0527 TD
[(pa)15.1(ra)19.2(me)12(tr)17.3(ic)-283.2(Ma)13.2(nn)21.2(-W)12.8(hi)18.9(tn)18.9(ey)-286.5(U-)15.7(te)18.4(st)17.7(,)-296.3(W)37.9(il)16.5(co)20.8(xo)15.5(n)-291(m)0(a)12(t)0(c)18.4(h)0(e)20.8(d)0(-)14(p)0(a)20.8(i)0(r)]TJ
T*
[(si)17.7(gn)15.5(ed)15.1(-r)18(an)20.8(k)-228.4(t)0(e)18.4(s)0(t)-221.3(a)0(n)20.8(d)-228.4(C)11.6(h)0(i)13.2(-)0(s)18.4(q)0(u)21.2(a)0(r)13.5(e)0(d)-218.2(t)0(e)18.5(s)0(t)-215.6(w)0(e)16.9(r)0(e)-219.8(u)0(s)14.4(e)0(d)20.8(.)-228(A)-226.6(p)0(-)19.6(v)0(a)15.1(l)0(u)18.9(e)]TJ
0 -1.0471 TD
(of)Tj
/F8 1 Tf
1.1381 0 TD
(<)Tj
/F4 1 Tf
0.5463 0 TD
[(0.)21.6(05)-314.5(wa)16.9(s)-326.3(c)0(o)15.1(n)0(s)20(i)0(d)18.9(e)0(r)13.5(e)0(d)-314.9(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)18.5(a)0(n)15.1(t)0(.)]TJ
/F7 1 Tf
8.1773 -3.1526 TD
[(Res)-7.8(ults)]TJ
/F4 1 Tf
-8.8602 -2.1055 TD
[(Th)17.1(e)-410.9(n)0(u)15.5(m)0(b)18.1(e)0(r)-401.9(o)0(f)-401.5(c)0(h)20.8(i)0(l)16.5(d)0(r)13.9(e)0(n)-400.3(r)0(e)19.2(t)0(e)18.4(s)0(t)17.7(e)0(d)-400.3(w)0(a)16.9(s)-411.7(20)15.5(5.)-399.5(S)11.4(i)0(n)18.9(c)0(e)-406.4(f)0(o)19.6(u)0(r)]TJ
-1.0015 -1.0471 TD
[(ch)15.1(il)16.5(dr)19.6(en)-445.8(we)16.9(re)-453.1(ab)20.8(se)19.6(nt)-447.8(fr)12.4(om)-442.8(th)13.2(e)-456.4(r)0(e)19.2(a)0(d)15.1(i)13.9(ng)-451.1(du)21.2(e)-456.4(t)0(o)-447.8(a)0(n)-445.8(a)0(c)14.7(u)0(t)18.8(e)]TJ
0 -1.0528 TD
[(il)16.5(ln)18.9(es)13.9(s,)-372.2(th)18.9(e)-382.4(f)0(i)17.3(n)0(a)15.1(l)-384.4(nu)21.2(mb)18.1(er)-379.1(w)12.4(a)0(s)-378.7(2)0(0)21.2(1)-382(\(1)13.9(00)-371.4(fe)19.2(ma)12(le)18.4(s)-383.2(a)0(n)20.8(d)-382(10)15.5(1)]TJ
0 -1.0471 TD
[(ma)12(le)18.4(s\))18.4(.)-290.6(T)0(h)17.1(e)-291.4(me)12(an)-280.8(ag)15.1(e)-291.4(o)0(f)-282(t)0(h)18.8(e)-297.1(ch)20.8(il)16.5(dr)19.6(en)-286.5(wa)16.9(s)-292.2(1)39.1(1.)21.6(3)-296.7(y)0(r)19.6(s)-292.2(\(r)18(an)15.1(ge)]TJ
0 -1.0528 TD
[(10)15.5(.4)15.9(\2611)21.2(2.)15.9(4)-416.2(y)0(r)19.6(s)0(\))12.8(.)-415.8(Th)17.1(e)-416.6(m)0(e)17.7(a)0(n)-411.7(d)0(i)18.8(a)0(m)12(e)0(t)18.4(e)0(r)-407.6(o)0(f)-412.8(t)0(h)18.8(e)-416.6(in)13.2(du)21.2(ra)13.5(t)13.9(i)0(o)13.2(n)-416.2(to)]TJ
0 -1.0471 TD
[(tu)13.2(be)20.8(rc)13.5(ul)18.9(in)-214.5(P)11.4(P)0(D)-215.2(R)62.8(T2)17.1(3)-222.7(w)0(a)16.9(s)-223.9(3.)15.9(2)-222.7(m)0(m)-212.7(\()0(r)18(a)0(n)15.1(g)0(e)-212.5(0)0(\261)15.5(2)0(8)-212.1(m)0(m)14.9(\))0(,)-213.3(t)0(o)]TJ
/F5 1 Tf
21.7379 0 TD
(M.)Tj
-21.7379 -1.0527 TD
[(sc)13.9(r)43.6(o)0(f)13.2(u)0(l)18.9(a)0(c)20.8(e)0(u)15.1(m)]TJ
/F4 1 Tf
5.6393 0 TD
[(3.)15.9(4)-427.6(m)0(m)-417.5(\()0(r)18(a)0(n)15.1(g)0(e)-417.3(0)0(\261)15.5(2)0(6)-416.9(m)0(m)14.9(\))-423.5(an)15.1(d)-427.6(t)0(o)]TJ
/F5 1 Tf
14.2321 0 TD
[(M.)-418.9(fo)18.9(r)20.8(-)]TJ
-19.8714 -1.0471 TD
[(tu)13.2(it)22.2(um)]TJ
/F4 1 Tf
2.8111 0 TD
[(1.)15.9(7)-325.1(m)13.2(m)-328.3(\()0(r)18(a)0(n)15.1(g)0(e)-314.9(0)0(\261)21.2(1)0(4)-320.2(m)0(m)14.9(\))-321(\(f)18(ig)13.2(.)-319.1(1\).)-327.9(The)-336.9(age)-338.8(of)-333.2(the)]TJ
-2.8111 -1.0528 TD
[(chil)-8.2(d)-564.1(had)-571.8(no)-564.9(infl)-9.4(uence)-568.4(on)-570.6(mean)-570.4(skin)-570(reaction)-577(sizes.)]TJ
0 -1.0471 TD
[(T)29.3(ubercul)-10.1(in)-248.6(react)-9(ion)-249.4(sizes)-259.8(were)-254.1(slightly)-255.8(smaller)-255.8(in)-254.3(females)]TJ
0 -1.0528 TD
[(\(2.9)-328.6(mm)-7.8(\))-321(than)-330.2(in)-322.6(mal)-8.2(es)-321.8(\(3.5)-328.6(mm\).)-329.2(Con)-7(versely)57(,)-324.7(reactions)]TJ
0 -1.0471 TD
(to)Tj
/F5 1 Tf
1.1836 0 TD
[(M.)-418.9(fortuitum)]TJ
/F4 1 Tf
5.5938 0 TD
[(sensi)-9(tin)-411.1(wer)-8.2(e)-410.9(larger)-409.3(in)-413.6(females)-418.9(than)-415.6(in)]TJ
-6.7774 -1.0527 TD
[(mal)-8.2(es)-333.2(\(2.0)]TJ
/F5 1 Tf
4.5524 0 TD
(versus)Tj
/F4 1 Tf
2.868 0 TD
[(1.4)-337.7(mm,)-332.6(p)]TJ
/F8 1 Tf
4.2167 0 TD
(<)Tj
/F4 1 Tf
0.552 0 TD
[(0.05\))-335.1(\(T)61(ab)-7.6(le)-334.4(1\).)]TJ
-11.1876 -1.0471 TD
[(No)11.6(ne)-269.4(of)-276.3(th)18.9(e)-285.7(c)0(h)20.8(i)0(l)16.5(d)0(r)13.9(e)0(n)-269.4(s)0(h)14.4(o)0(w)17.3(e)0(d)-275.1(a)0(n)20.8(y)-285.3(cl)18.4(in)18.9(ic)18.4(al)-277.5(ma)17.7(ni)18.9(fe)13.5(st)17.7(at)18.5(io)18.8(n)]TJ
-1.0015 -1.0527 TD
[(of)-367.3(a)-376.8(m)0(y)18.1(c)0(o)20.8(b)0(a)15.1(c)0(t)18.4(e)0(r)13.5(i)0(o)18.8(s)0(i)17.7(s)0(.)-366.5(N)12.4(o)-376.3(c)0(a)20.4(s)0(e)13.9(s)-371.8(of)-367.3(tu)18.9(be)15.1(rc)19.2(ul)18.9(os)14.4(is)-363.6(ha)15.1(d)-370.7(b)0(e)15.1(e)0(n)]TJ
0 -1.0471 TD
[(di)13.2(ag)20.8(no)15.5(se)19.6(d)-427.6(a)0(m)12(o)0(n)21.2(g)-427.6(th)13.2(e)-428(s)0(t)17.7(u)0(d)21.2(y)-433.3(gr)19.6(ou)15.5(p)-427.6(d)0(u)21.2(r)0(i)17.3(n)0(g)-422.6(t)0(h)18.8(e)-428(fo)14(ll)16.5(ow)17.3(-u)19.6(p)]TJ
0 -1.0528 TD
[(pe)15.1(ri)17.3(od)15.5(.)-427.2(S)11.4(ev)15.1(en)-417.3(ch)15.1(il)16.5(dr)19.6(en)-417.3(ha)15.1(d)-427.6(b)0(e)15.1(e)0(n)-417.3(i)0(n)-419.3(t)0(u)13.2(b)0(e)20.8(r)0(c)19.2(u)0(l)13.2(o)0(s)20(i)0(s)-420.5(c)0(o)15.1(n)0(t)18.8(a)0(c)20.4(t)]TJ
0 -1.0471 TD
[(an)15.1(d)-245.5(t)13.9(he)15.1(re)19.2(fo)13.9(re)-236.8(ha)20.8(d)-245.5(a)0(l)18.5(s)0(o)-236(b)0(e)20.8(e)0(n)-235.2(t)0(e)18.5(s)0(t)17.7(e)0(d)-235.2(f)0(o)13.9(r)-241.4(tu)18.9(be)15.1(rc)19.2(ul)18.9(in)-237.2(re)19.2(ac)14.7(ti)16.5(vi)18.8(ty)81.5(.)]TJ
0 -1.0527 TD
[(In)-304.7(al)18.4(l)-310.4(c)0(a)14.7(s)0(e)19.6(s)0(,)-303.9(t)0(h)18.9(e)-308.5(te)12.8(st)17.7(in)18.8(g)-308.1(h)0(a)15.1(d)-308.1(be)15.1(en)-303.5(do)21.2(ne)]TJ
/F8 1 Tf
15.4954 0 TD
(>)Tj
/F4 1 Tf
0.5406 0 TD
[(1)-313.7(y)0(r)19.6(s)-314.9(pr)19.6(io)18.9(r)-309.7(t)0(o)-305.5(t)0(h)18.9(e)]TJ
-16.036 -1.0471 TD
[(pr)13.9(es)19.6(en)15.1(t)-390.1(s)0(t)17.7(u)0(d)15.5(y)73.2(.)-393(T)0(h)17.1(e)0(r)19.2(e)-393.8(wa)16.9(s)-394.6(n)0(o)-382.8(d)0(i)18.9(f)14.7(fe)19.2(re)19.2(nc)15.1(e)-393.8(i)0(n)-385.2(t)0(h)18.9(e)0(i)18.4(r)-395(sk)20(in)-385.2(te)18.4(st)]TJ
0 -1.0528 TD
[(re)13.5(ac)20.4(ti)16.5(vi)18.9(ty)-316.9(co)15.1(mp)18.1(ar)19.2(ed)-314.9(to)-316.9(th)18.9(e)-325.5(o)0(t)18.9(h)0(e)15.1(r)-321(ch)15.1(il)16.5(dr)19.6(en)15.1(.)]TJ
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[(0.)15.9(05)21.2(\))-497.4(s)0(m)16.9(a)0(l)18.4(l)0(e)18.4(r)-497.4(in)-487.6(ch)20.8(il)16.5(dr)19.6(en)]TJ
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12.4737 0 TD
[(ve)14.7(rs)18.9(us)]TJ
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2.7372 0 TD
[(3.)21.6(8)-251.2(m)13.2(m\))10.8(.)-245.1(T)0(h)17.1(e)-245.9(sa)13.9(me)]TJ
9.9869 66.1583 TD
[(te)12.8(nd)21.2(en)15.1(cy)-354.8(wa)16.9(s)-366.2(o)0(b)15.5(s)0(e)19.6(r)0(v)13.9(e)0(d)-354.7(i)0(n)-356.7(r)0(e)13.5(a)0(c)20.4(t)0(i)16.5(o)0(n)15.5(s)-366.2(to)]TJ
/F5 1 Tf
15.7742 0 TD
[(M.)-356.3(fo)18.9(rt)17.7(ui)13.2(t)13.9(u)0(m)]TJ
/F4 1 Tf
5.4117 0 TD
[(se)19.6(n-)]TJ
-21.1859 -1.0471 TD
[(si)17.7(ti)16.5(n,)-427.9(al)18.5(th)13.2(ou)21.2(gh)-428.3(th)18.9(e)-439.3(d)0(i)18.9(f)14.7(fe)19.2(re)19.2(nc)15.1(es)-429.9(we)16.9(re)-430.3(no)21.2(t)-441.3(s)0(t)17.7(a)0(t)18.4(i)0(s)17.7(t)0(i)16.5(c)0(a)20.4(l)0(l)16.5(y)-438.9(si)17.7(g-)]TJ
0 -1.0528 TD
[(ni)13.2(fi)17.3(ca)20.4(nt)-316.9(\(t)17.3(ab)15.1(l)13.9(e)-325.5(1\).)]TJ
1.0015 -1.0471 TD
[(In)-355.9(co)15.1(nt)18.9(ra)13.5(st)17.7(,)-358.9(c)0(o)15.1(n)0(t)18.9(a)0(c)14.7(t)-361.6(wi)14.9(th)-356.7(pe)20.8(ts)-357.9(or)-355.9(fa)19.2(rm)-359.1(an)20.8(im)15.7(al)18.4(s)-366.2(w)0(a)16.9(s)-366.2(as)19.6(-)]TJ
-1.0015 -1.0528 TD
[(so)14.4(ci)18.4(at)18.5(ed)-383.2(wi)14.9(t)13.9(h)-393.4(la)18.5(r)20.4(g)0(e)15.1(r)-389.3(re)19.2(ac)14.7(ti)16.5(on)21.2(s)-394.6(t)13.9(o)-393.4(t)0(u)18.9(b)0(e)15.1(r)0(c)19.2(u)0(l)18.9(i)0(n)-379.5(a)0(n)15.1(d)-387.7(se)13.9(ns)20(it)16.5(in)18.8(s)]TJ
0 -1.0471 TD
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0 -1.0528 TD
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0 -1.0471 TD
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0 -1.0527 TD
[(to)-237.2(tuberculi)-10.7(n,)-228.8(3.8)-235.2(mm)-235.4(to)]TJ
/F5 1 Tf
9.765 0 TD
[(M.)-231.1(scr)29.1(o)-6.5(fulaceum)]TJ
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6.8571 0 TD
[(sensi)-9(tin)-229(and)-236(1.9)]TJ
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[(mm)-457.4(to)]TJ
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[(M.)-453.1(fortuitum)]TJ
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5.6678 0 TD
[(sensiti)-9.6(n,)-445(whi)-8.6(ch)-445.8(wer)-8.2(e)-450.7(signifi)-9.6(cantly)]TJ
-8.8829 -1.0471 TD
[(larger)-323.9(than)-324.5(in)-328.3(children)-331.9(without)-329.4(co)-7.6(ntacts)-330(with)-324.7(anim)-9(als.)-325.3(In)]TJ
0 -1.0528 TD
[(chil)-8.2(dren)-232.7(living)-239.3(on)-229.1(a)-234.5(farm)-237.4(\(n)]TJ
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(=)Tj
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[(16\),)-231.9(mean)-240.3(skin)-234.2(reaction)-241.3(sizes)]TJ
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[(to)-294.1(tuber)-8.2(culin)-293.5(and)]TJ
/F5 1 Tf
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[(M.)-288(scr)23.4(ofulaceum)]TJ
/F4 1 Tf
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(and)Tj
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1.7299 0 TD
[(M.)-288(fortu)-9.8(itum)]TJ
/F4 1 Tf
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(sen-)Tj
-21.1518 -1.0527 TD
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0 -1.0471 TD
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3.2721 0 TD
[(M.)-282.3(fort)-9(uitum)]TJ
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[(sensi)-9(tin)-285.9(were)-288.2(signifi)-9.6(cantly)-289(\(p)]TJ
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(<)Tj
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(0.05\))Tj
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[(larger)-335.3(in)-334(children)-343.3(living)-336.1(on)-337.3(a)-336.9(farm.)]TJ
1.0015 -1.0471 TD
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-1.0015 -1.0528 TD
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0 -1.0471 TD
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0 -1.0527 TD
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0 -1.0471 TD
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/F7 1 Tf
9.1675 -3.9606 TD
[(Discu)-10.9(ssion)]TJ
/F4 1 Tf
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-1.0015 -1.0528 TD
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0 -1.0471 TD
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0 -1.0528 TD
[(be)15.1(rc)19.2(ul)13.2(i)13.9(n)-268.2(re)19.2(ac)14.7(ti)16.5(vi)18.8(ty)-254.3(fr)18(om)-260.7(ea)20.4(rl)17.3(y)-268.2(c)0(h)20.8(i)0(l)16.5(d)0(h)21.2(o)0(o)15.5(d)-262.5(to)-260(ad)20.8(ol)18.9(es)13.9(ce)20.4(nc)15.1(e.)-257.6(A)]TJ
0 -1.0471 TD
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0 -1.0527 TD
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0 -1.0471 TD
[(an)15.1(d)-416.2(9)0(.)21.6(2)-416.2(mm)14.9(,)-415.8(r)0(e)19.2(s)0(p)20(e)0(c)14.7(t)0(i)16.5(v)0(e)20.8(l)0(y)-407.9([)0(1)13.9(7].)-413.2(In)-429.9(a)-422.3(more)-429.3(recent)-430.9(study)55.2(,)]TJ
0 -1.0527 TD
[(perfor)-9.8(med)-318.8(in)-311.2(ch)-7.6(ildren)-318.6(1)33.4(1\26113)-316(yrs)-318.1(of)-316.1(age,)-316.5(the)-318.1(mean)-314.3(tuber-)]TJ
0 -1.0471 TD
[(culi)-8.2(n)-325.1(reaction)-332.3(size)-326.1(was)-326.5(8.2)-326.3(mm)-326.5([18].)-331(Compar)-8.7(ed)-326.3(to)-322.6(these)]TJ
0 -1.0528 TD
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0 -1.0471 TD
[(chil)-8.2(dren)-266.8(reveal)-9.8(ed)-269.4(an)-269.4(unexpected)-11.6(ly)-265.7(small)-269.4(mean)-274.5(indur)-7.8(ation)]TJ
0 -1.0527 TD
[(size)-292(\(4.8)-288.8(mm)-7.8(\))-286.9(with)-290.6(a)-285.7(signifi)-9.6(cant)-290.8(age-relate)-11.9(d)-285.3(decline)-295.8(from)]TJ
0 -1.0471 TD
[(4\2616)-383.6(yrs)-380.7([15].)-382.2(Six)-379.5(years)-388.7(later)28.9(,)-381.6(the)-380.6(same)-383.8(children)-383.2(y)-6.5(ielded)]TJ
0 -1.0528 TD
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0 -1.0471 TD
[(earli)-11(er)-413.2(Finni)-7.8(sh)-418.1(study)-417.1(of)-418.5(chil)-8.2(dren)-414.8(of)-418.5(the)-420.5(same)-417.9(age)-418.5([18].)]TJ
0 -1.0528 TD
[(Thu)-6.4(s)-332(the)-335.1(p)-6.5(resent)-340.6(results)-338.8(were)-339.4(unexpect)-9.7(ed.)]TJ
1.0015 -1.0471 TD
[(As)-325.3(fa)19.2(r)-332.4(a)0(s)-316.1(t)0(h)13.2(e)-325.5(au)15.1(th)18.9(or)19.6(s)-332(a)0(r)19.2(e)-331.2(aw)16.9(ar)19.2(e,)-320.2(ea)14.7(rl)17.3(ie)18.5(r)-326.7(s)0(t)17.7(u)0(d)15.5(i)0(e)18.4(s)-332(on)-320.2(se)19.6(n-)]TJ
-1.0015 -1.0528 TD
[(si)17.7(ti)16.5(za)14.7(ti)16.5(on)-490.9(to)-499(en)20.8(vi)18.9(ro)13.9(nm)18.1(en)20.8(ta)12.8(l)-503.9(m)0(y)18.1(c)0(o)20.8(b)0(a)15.1(c)0(t)18.5(e)0(r)13.5(i)0(a)-493.7(h)0(a)20.8(v)0(e)-497(a)0(l)18.4(l)-503.9(be)15.1(en)]TJ
0 -1.0471 TD
[(cr)13.5(os)20(s-)18.4(se)14(ct)18.5(io)18.9(na)15.1(l.)-470.2(In)-469.7(th)18.9(e)-479.2(p)0(r)13.9(e)0(s)19.6(e)0(n)15.1(t)-475.5(st)17.7(ud)15.5(y)73.2(,)-478.4(th)18.8(e)-484.9(s)0(a)19.6(m)0(e)-471.7(c)0(h)20.8(i)0(l)16.5(d)0(r)13.9(e)0(n)]TJ
0 -1.0527 TD
[(we)16.9(re)-253.9(pr)19.6(os)20(pe)15.1(ct)18.4(iv)18.8(el)12.8(y)-256.8(f)0(o)19.6(l)0(l)16.5(o)0(w)17.3(e)0(d)-246.6(f)0(o)14(r)-252.7(ch)15.1(an)20.8(ge)15.1(s)-258(i)0(n)-248.6(t)0(h)18.9(e)0(i)18.5(r)-258.4(re)19.2(ac)14.7(ti)16.5(vi)18.8(ty)]TJ
0 -1.0471 TD
[(to)-402.3(m)13.2(y)0(c)15.1(o)0(b)15.5(a)0(c)20.4(t)0(e)18.4(r)0(i)17.3(a)0(l)-397(a)0(n)15.1(t)0(i)16.5(g)0(e)20.8(n)0(s)14.4(.)-404.4(On)17.3(ly)-396.6(ch)15.1(il)16.5(dr)19.6(en)-394.6(li)16.5(vi)18.9(ng)-399.9(co)20.8(nt)13.2(in)18.9(u-)]TJ
0 -1.0528 TD
[(ou)15.5(sl)17.7(y)-279.6(i)0(n)-265.7(t)0(h)13.2(e)-274.3(sa)14(me)-266.8(co)15.1(mm)14.9(un)21.2(it)16.5(y)-279.6(w)0(e)16.9(r)0(e)-271(i)0(n)18.8(c)0(l)18.5(u)0(d)15.5(e)0(d)-269.4(i)0(n)-271.4(t)0(h)18.9(e)-280(te)18.4(st)17.7(in)18.8(g)]TJ
0 -1.0471 TD
[(to)-214.5(av)15.1(oi)18.9(d)-222.7(t)0(h)18.9(e)-223.1(po)21.2(te)18.4(nt)13.2(i)13.9(a)0(l)-214.9(c)0(o)15.1(n)0(f)19.6(o)0(u)15.5(n)0(d)21.2(i)0(n)18.9(g)-222.7(ef)24.9(fe)19.2(ct)-214.9(ca)20.4(us)14.4(ed)-212.5(by)-212.1(ch)20.8(an)15.1(ge)]TJ
0 -1.0527 TD
[(of)-208(en)15.1(vi)18.9(ro)19.6(nm)18.1(en)15.1(t,)-202.7(wh)17.3(ic)12.8(h)-211.3(i)0(s)-204.3(t)0(h)13.2(e)-211.7(li)16.5(ke)20.8(li)16.5(es)14(t)-213.7(s)0(o)20(u)0(r)13.9(c)0(e)-201.5(o)0(f)-208(e)0(x)15.1(p)0(o)21.2(s)0(u)14.4(r)0(e)-202.7(t)0(o)]TJ
0 -1.0471 TD
[(en)15.1(vi)18.9(ro)13.9(nm)18.1(en)20.8(ta)12.8(l)-270.6(m)0(y)18.1(c)0(o)15.1(b)0(a)20.8(c)0(t)18.5(e)0(r)13.5(i)0(a)-260.4([)0(2)13.9(2].)-271(The)-285.7(initial)-290.8(study)-286.2(show-)]TJ
0 -1.0528 TD
[(ed)-553.9(a)-547.5(decreas)-9.7(e)-547.5(i)0(n)-550.2(mycob)-7.4(acter)-9(ial)-553.7(sensitizati)-12.5(on)-547.8(with)-552.4(in-)]TJ
T*
[(creasi)-11(ng)-223.5(age)-225(from)-231.3(4)-222.7(t)0(o)-225.8(6)-222.7(yrs)-227([16].)-228.6(An)-221.7(e)-6.9(arlier)-229.6(Finnish)-226.7(study)]TJ
0 -1.0471 TD
[(on)-303.1(mycob)-7.4(acterial)-306.7(sensiti)-9.6(vity)-303.7(in)-299.8(BCG-vac)-9.7(cinated)-307.2(children)]TJ
0 -1.0527 TD
[(age)-8.8(d)-365(1)33.4(1\2611)-8(3)-365(yrs)-369.3(had)-366.9(show)-8.2(n)-365(signi)-9.8(ficantly)-374.2(larger)-363.8(skin)-370.8(test)]TJ
0 -1.0471 TD
[(react)-9(ion)-391.6(sizes)-396.3(than)-392.8(detected)-393.7(in)-390.9(the)-392(author)-9(s)]TJ
/F12 1 Tf
17.3505 0 TD
(')Tj
/F4 1 Tf
0.6089 0 TD
[(initial)-393.2(study)]TJ
-17.9594 -1.0527 TD
[([17].)-433.4(It)-432.3(was)-434.6(therefore)-436.3(expect)-8.2(ed)-428.7(that)-435(there)-429.7(woul)-9.4(d)-427.6(b)0(e)-428.7(a)0(n)]TJ
0 -1.0471 TD
[(incre)-8.6(ase)-294.5(in)-294.1(reactions)-300.2(size)-292(as)-293.3(the)-295.3(children)-297.8(aged)-294.1(from)-293.9(6)-291(yrs)]TJ
0 -1.0528 TD
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19.3479 0 TD
0.5316 Tc
[(\310g)531.6(r)551.2(o)531.6(u)552.8(p)531.6(\))]TJ
-19.3479 -1.0755 TD
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T*
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[(M.)-470.1(tuber)26.4(culos)-7.8(is)]TJ
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(')Tj
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[(study)60.9(,)-273.5(children)-280.7(with)-273.5(alle)-8.6(rgic)]TJ
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(or)Tj
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T*
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2.5165 -1.1065 TD
[(cination)-236.6(and)-238.5(mycobacterial)-242.5(cervical)-234.7(adenitis)-244.1(in)-235.3(childhood.)]TJ
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[(1987;)-328.6(68:)-336(291\261296.)]TJ
-6.285 -1.1128 TD
[(1)32.1(1)0(.)-1298.6(Mar)12.8(gileth)-421.2(AM.)-416.9(Cervical)-423(adenitis.)]TJ
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16.5913 0 TD
[(Pediatr)-416.6(Rev)]TJ
/F4 1 Tf
5.286 0 TD
[(1985;)-417.1(7:)]TJ
-19.3608 -1.1065 TD
(13\26124.)Tj
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[(12.)-1266.5(Larsson)-281.3(LO,)-286.9(Skoogh)-286.4(BE,)-288.3(Bentzon)-287.6(MW)83.2(,)]TJ
/F5 1 Tf
18.8043 0 TD
[(et)-285.7(al)]TJ
/F4 1 Tf
1.7641 0 TD
[(.)-287.4(Sensitivity)]TJ
-18.0519 -1.1128 TD
[(to)-494.6(sensitins)-499.1(and)-491.4(tuberculin)-502.1(in)-494.6(Swedish)-494.8(children.)-497.3(II.)-497(A)]TJ
T*
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/F5 1 Tf
11.6531 0 TD
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[(13.)-1266.5(Larsson)-357.1(LO,)-362.8(Bentzon)-363.5(MW)83.2(,)-357(Lind)-364.2(A,)]TJ
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[(et)-361.6(al)]TJ
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1.84 0 TD
[(.)-357(Sensitivity)-366.3(to)]TJ
-16.8506 -1.1128 TD
[(sensitins)-410.6(and)-415.6(tuberculin)-413.6(in)-412.4(Swedish)-412.6(children.)-415.1(Part)-410.7(5.)-413.4(A)]TJ
T*
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19.3797 0 TD
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[(14.)-1266.5(Lind)-389.5(A,)-391.4(Bentzon)-388.8(MW)83.2(,)-388.6(Doshee)-393(IM,)]TJ
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[(.)-388.6(Sensitivity)-397.9(to)]TJ
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T*
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T*
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T*
[(Acta)-332.4(Paediatr)]TJ
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[(1992;)-334.9(81:)-329.7(891\261895.)]TJ
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[(BCG-vaccinated)-572.9(children)-570.3(and)-567.3(youths.)]TJ
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16.4522 0 TD
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-16.4522 -1.1128 TD
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[(18.)-1266.5(T)66.6(ala-Heikkila)]TJ
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-5.0394 -1.1128 TD
[(T)66.6(ala)-234.4(E.)-239.8(Sensitivity)-233.5(to)-235.3(PPD)-239.2(tuberculin)-236.5(and)]TJ
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16.4459 0 TD
[(M)-240.2(scr)31(ofulaceum)]TJ
/F4 1 Tf
-16.4459 -1.1128 TD
[(sensitin)-681.8(in)-684.3(schoolchildren)-684.4(BCG)-687.8(vaccinated)-681.4(at)-684(birth.)]TJ
/F5 1 Tf
T*
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[(19.)-1266.5(Osman)-597.9(AA,)-602.8(Hakim)-605.5(JK,)-600.7(Luneborg-Nielsen)-593.8(M,)]TJ
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/F4 1 Tf
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-18.8612 -1.1128 TD
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1.9095 0 TD
[(M.)-464.4(scr)31(ofulaceum)]TJ
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-15.175 -1.1128 TD
[(children)-399.5(in)-406(Saudi)-396.5(Arabia.)]TJ
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2.5165 -1.1128 TD
[(mycobacteria:)-539.7(Antigens.)]TJ
/F5 1 Tf
10.496 0 TD
(In)Tj
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0.822 0 TD
[(:)-539.3(Ratledge)-535.8(C,)-538.2(Stanford)-542.4(JL,)]TJ
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2.5165 -1.1065 TD
[(pathogenic)-302.5(mycobacteria.)]TJ
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(287\261292.)Tj
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[(23.)-1266.5(Horwitz)-274.1(O,)-277.6(Bunch-Christensen.)-277.6(Correlation)-279.6(between)-273.3(tub-)]TJ
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(49\26158.)Tj
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2.5165 -1.1065 TD
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-19.2027 -1.1128 TD
(Child)Tj
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2.5165 -1.1128 TD
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20.9984 0 TD
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-20.9984 -1.1065 TD
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-4.7864 -1.1128 TD
[(26.)-1266.5(Kro)]TJ
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/F5 1 Tf
13.6006 0 TD
[(et)-519.6(al)]TJ
/F4 1 Tf
1.998 0 TD
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-16.7367 -1.1128 TD
[(newborn)-455.7(vaccination)-462.2(with)-461.3(three)-455.6(different)-451.5(Bacillus)-463.8(Cal-)]TJ
T*
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/F5 1 Tf
0 -1.1065 TD
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/F4 1 Tf
8.3526 0 TD
[(1994;)-328.6(13:)-336(1)32.1(13\2611)27.3(16.)]TJ
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[(27.)-1266.5(Iivanainen)-221.3(EK,)-217.3(Martikainen)-223.8(PJ,)-216.6(V)104.7(a)]TJ
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(\310a)Tj
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[(\310n)51.1(a)]TJ
0.9358 0 TD
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10.4897 0 TD
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10.0598 0 TD
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[(59:)-336(398\261404.)]TJ
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[(28.)-1266.5(Bjerkedal)-656.4(T)72.9(.)-654.2(Mycobacterial)-658.6(infections)-655(in)-652.6(Norway:)-657.4(a)]TJ
2.5165 -1.1128 TD
[(preliminary)-441.2(note)-442.7(on)-435.3(determining)-440.2(their)-439.2(identity)-441.5(and)-440.9(fre-)]TJ
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[(29.)-1266.5(Dascalopoulos)-673.3(GA,)-672.4(Loukas)-671.6(S,)-671.2(Constantopoulos)-670.3(SH.)]TJ
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T*
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17.8749 0 TD
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-17.8749 -1.1128 TD
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[(31.)-1266.5(Gomstock)-567.2(GW)80.6(.)-565.7(Identification)-568.8(of)-569(an)-567.8(effective)-557.6(vaccine)]TJ
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(480.)Tj
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[(32.)-1266.5(Fine)-441.3(PEM.)-440.4(V)104.7(accines,)-438.3(genes)-440.8(and)-440.9(trials.)]TJ
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18.8802 0 TD
[(Novartis)-437.5(Found)]TJ
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(Symp)Tj
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[(1999;)-328.6(217:)-335.5(57\26172.)]TJ
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2.5165 -1.1128 TD
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T*
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T*
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(Science)Tj
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[(35.)-1266.5(Alm)-309.6(JS,)-305.2(Lilja)-311.4(G,)-309.2(Pershagen)-311.6(G,)-309.2(Scheynius)-306.9(A.)-309.2(Early)-313.9(BCG)]TJ
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(400\261403.)Tj
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T*
[(Soc)-331.9(for)-335.5(Microbiol,)-335.7(1988;)-334.9(pp.)-330.7(415\261421.)]TJ
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[(997;)-335.5(52:)-329.7(1036\2611037.)]TJ
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[(1994;)-334.9(83:)-329.6(232\261234.)]TJ
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(387)Tj
7.472 0 0 7.472 224.787 797.499 Tm
0.0001 Tc
[(TUBERCULIN)-344.9(AND)-334.5(SENSITIN)-342.2(REACTIO)-11.3(N)0(S)]TJ
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