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[(th)18.9(er)13.5(e)-319.8(w)0(e)16.9(r)0(e)-310.8(n)0(o)-314.5(p)0(r)19.6(e)0(v)15.1(i)13.9(ou)15.5(s)-320.6(d)0(a)15.1(t)13.9(a)-325.5(a)0(v)20.8(a)0(i)18.5(l)0(a)12.8(b)0(l)18.9(e)-319.8(re)19.2(ga)15.1(rd)19.6(in)13.2(g)-319.4(n)0(i)18.9(g)0(h)21.2(t)-321.8(co)15.1(-)]TJ
0 -1.0471 TD
[(ug)15.5(h)-308.1(c)0(o)20.8(u)0(n)15.5(t)0(s)-301(i)0(n)-299.8(i)0(n)18.9(f)0(a)13.5(n)0(t)18.9(s)-309.2(re)19.2(co)15.1(ve)20.8(ri)17.3(ng)-303.1(fr)18(om)-300.6(ac)14.7(ut)18.9(e)-308.5(b)0(r)19.6(o)0(n)15.5(c)0(h)15.1(i)0(o)18.9(l)0(i)16.5(t)0(i)16.5(s)0(.)]TJ
1.0015 -1.0528 TD
[(Ot)14.9(he)20.8(r)-577.1(a)0(s)19.6(s)0(e)19.6(s)0(s)13.2(m)0(e)17.7(n)0(t)18.9(s)-571(of)-566.5(th)18.9(e)-575.9(e)0(f)30.6(f)0(e)13.5(c)0(t)18.4(s)-571(of)-566.5(in)18.9(ha)15.1(l)13.9(e)0(d)-565.3(F)0(P)-563.3(o)0(n)]TJ
-1.0015 -1.0471 TD
[(br)19.6(on)15.5(ch)15.1(i)13.9(o)0(l)13.2(i)0(t)16.5(i)13.9(s)-309.2(w)0(e)16.9(r)0(e)-299.4(b)0(a)20.8(s)0(e)13.9(d)-302.4(up)15.5(on)-297.4(di)18.9(ar)13.5(y)-302.4(r)0(e)13.5(c)0(o)20.8(r)0(d)13.9(s)-303.6(of)-299(sy)20(mp)12.4(to)18.9(ms)]TJ
0 -1.0528 TD
[(co)15.1(mp)18.1(le)18.4(te)18.4(d)-518.6(b)0(y)-508(p)0(a)15.1(r)0(e)19.2(n)0(t)18.9(s)-519.8(an)20.8(d)-518.6(o)0(v)15.5(e)0(r)19.2(n)0(i)18.9(g)0(h)15.5(t)-515.3(ox)15.5(yg)21.2(en)-514.1(sa)19.6(tu)18.9(ra)19.2(ti)16.5(on)]TJ
0 -1.0471 TD
[(me)17.7(as)14(ur)19.6(em)17.7(en)15.1(ts)17.7(.)-290.6(P)0(u)16.3(l)0(m)15.7(o)0(n)21.2(a)0(r)13.5(y)-291(fu)19.6(nc)15.1(ti)16.5(on)-280.4(an)15.1(d)-291(b)0(r)14(o)0(n)21.2(c)0(h)15.1(i)0(a)18.4(l)-293.4(re)19.2(ac)14.7(ti)16.5(v-)]TJ
0 -1.0527 TD
[(it)16.5(y)-273.9(t)0(e)18.4(s)0(t)17.7(i)0(n)18.9(g)-273.9(we)16.9(re)-265.3(al)18.4(so)-264.5(pe)15.1(rf)18(or)13.9(me)17.7(d)-273.9(3)-273.9(m)0(o)18.1(n)0(t)18.9(h)0(s)-264.5(a)0(f)13.5(t)13.9(er)-265.3(co)15.1(mp)18.1(le)12.8(t)13.9(i)0(o)13.2(n)]TJ
0 -1.0471 TD
[(of)-316.1(th)18.8(e)-325.5(t)0(r)17.3(i)0(a)18.4(l)-327.5(me)17.7(di)18.9(ca)14.7(ti)22.2(on)15.5(s.)]TJ
1.0015 -1.0528 TD
[(Pa)15.9(re)19.2(nt)18.9(s)-320.6(w)0(e)16.9(r)0(e)-310.8(a)0(s)19.6(k)0(e)15.1(d)-319.4(to)-305.5(re)13.5(co)20.8(rd)-310.4(sy)20(mp)12.4(to)18.9(ms)-313.2(t)13.9(w)0(i)14.9(c)0(e)-309.6(d)0(a)15.1(i)0(l)16.5(y)-313.7(on)]TJ
-1.0015 -1.0471 TD
[(di)18.9(ar)13.5(y)-393.4(c)0(a)20.4(r)0(d)13.9(s)-394.6(du)21.2(ri)17.3(ng)-388.5(th)18.9(e)-393.8(3)0(-)19.6(m)0(o)12.4(n)0(t)18.9(h)-393.4(tr)17.3(ea)14.7(tm)15.7(en)20.8(t)-395.8(p)0(e)20.8(r)0(i)11.6(o)0(d)21.2(.)-393(Th)17.1(er)13.5(e-)]TJ
0 -1.0527 TD
[(af)19.2(te)12.8(r)43.2(,)-529.6(th)18.9(ey)-519.8(re)19.2(co)15.1(rd)19.6(ed)-519.8(sy)20(mp)18.1(to)13.2(ms)-518(fo)19.6(r)-531.6(t)0(h)18.9(e)-524.7(2-)14(we)16.9(ek)-519.8(pe)20.8(ri)17.3(od)15.5(s)]TJ
0 -1.0471 TD
[(im)15.7(me)17.7(di)18.9(at)12.8(el)18.4(y)-199.9(p)0(r)19.6(e)0(c)14.7(e)0(d)20.8(i)0(n)13.2(g)-199.9(3-)19.6(mo)18.1(nt)13.2(hl)18.9(y)-199.9(r)0(e)19.2(v)0(i)13.2(e)0(w)16.9(s)0(.)-190.1(C)11.6(ou)15.5(gh)15.5(,)-199.6(w)0(h)17.3(e)0(e)20.4(z)0(e)]TJ
0 -1.0528 TD
[(an)15.1(d)-273.9(g)0(e)20.8(n)0(e)15.1(r)0(a)19.2(l)-276.3(w)12.4(e)0(l)12.8(l)0(-)17.3(b)0(e)20.8(i)0(n)18.9(g)-273.9(we)16.9(re)-265.3(sc)13.9(or)19.6(ed)-263.7(0\261)15.5(3)-273.9(\()0(0)]TJ
/F10 1 Tf
16.77 0 TD
(=)Tj
/F6 1 Tf
0.5463 0 TD
[(no)21.2(ne)15.1(,)-273.5(1)]TJ
/F10 1 Tf
2.9136 0 TD
(=)Tj
/F6 1 Tf
0.5463 0 TD
[(mi)21.4(ld)13.2(,)]TJ
-20.7762 -1.0527 TD
(2)Tj
/F10 1 Tf
0.4894 0 TD
(=)Tj
/F6 1 Tf
0.5463 0 TD
[(tr)17.3(ou)21.2(bl)13.2(es)19.6(om)18.1(e,)-240.6(an)15.1(d)-251.2(3)]TJ
/F10 1 Tf
7.4546 0 TD
(=)Tj
/F6 1 Tf
0.5406 0 TD
[(se)13.9(ve)20.8(re)13.5(\))-247.1(f)0(o)13.9(r)-247.1(bo)15.5(th)-242.9(da)20.8(y)-251.2(a)0(n)20.8(d)-251.2(ni)18.9(gh)15.5(t.)-242.5(T)12.2(h)0(e)]TJ
-9.0309 -1.0471 TD
[(us)20(e)-228.8(o)0(f)-213.7(M)0(D)15.3(I)0(s)-214.9(w)0(a)16.9(s)-223.9(al)18.5(so)-213.3(re)13.5(co)20.8(rd)13.9(ed)-212.5(an)20.8(d)-228.4(M)0(D)15.3(I)0(s)-214.9(w)12.4(ei)12.8(gh)21.2(ed)-218.2(ev)20.8(er)19.2(y)-228.4(3)]TJ
0 -1.0527 TD
[(we)16.9(ek)15.1(s)-360.5(b)0(e)20.8(f)0(o)13.9(r)0(e)-350.7(t)0(h)13.2(e)-359.7(ne)15.1(xt)-351(MD)15.3(I)-360.9(w)0(a)16.9(s)-366.2(i)13.9(s)0(s)13.2(u)0(e)20.8(d)0(.)-354(T)0(h)17.1(e)-359.7(me)12(an)-349.1(co)15.1(m-)]TJ
0 -1.0471 TD
[(pl)18.9(ia)18.4(nc)15.1(e)-251.6(o)0(f)-236.4(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-238.4(i)0(n)-242.9(e)0(a)20.4(c)0(h)-240.9(g)0(r)13.9(o)0(u)21.2(p)-251.2(wa)16.9(s)-246.7(c)0(a)14.7(l)0(c)18.4(u)0(l)18.9(a)0(t)18.4(e)0(d)-240.9(s)0(e)13.9(p)0(a)20.8(r)0(a)13.5(t)13.9(el)12.8(y)]TJ
0 -1.0527 TD
[(fo)19.6(r)-366.6(t)0(h)18.9(e)-365.4(di)13.2(ar)19.2(y)-365(a)0(n)15.1(d)-365(MD)15.3(I)-360.9(w)0(e)11.2(i)13.9(gh)15.5(t)-367.3(l)0(o)18.9(s)0(s)18.9(e)0(s)13.9(.)-364.6(F)11.4(a)0(m)17.7(i)0(l)16.5(y)-365(do)15.5(ct)18.4(or)-355.9(an)15.1(d)]TJ
0 -1.0471 TD
[(ho)15.5(sp)20(it)16.5(al)-254.7(re)19.2(co)15.1(rd)19.6(s)-263.7(w)0(e)16.9(r)0(e)-259.6(e)0(x)20.8(a)0(m)12(i)0(n)18.9(e)0(d)-252.3(a)0(t)-260.4(t)13.9(he)-258(en)15.1(d)-262.5(o)0(f)-253.5(t)0(h)18.9(e)-268.6(st)17.7(ud)21.2(y)-262.5(f)0(o)13.9(r)]TJ
0 -1.0528 TD
[(co)15.1(rr)18(ob)21.2(or)13.9(at)18.5(iv)18.9(e)-325.5(i)0(n)18.9(f)0(o)13.9(r)0(m)16.5(a)0(t)18.5(i)0(o)18.9(n)0(.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(e)-342.6(s)0(a)19.6(f)0(e)13.5(t)0(y)-334(o)0(f)-333.2(t)0(h)18.9(e)-342.6(in)13.2(ha)20.8(le)18.4(d)-342.2(s)0(t)17.7(e)0(r)13.5(o)0(i)18.9(d)-342.2(th)18.9(er)13.5(ap)20.8(y)-342.2(w)0(a)16.9(s)-343.4(as)13.9(se)19.6(ss)18.9(ed)]TJ
-1.0015 -1.0528 TD
[(by)-325.9(me)17.7(an)15.1(s)-332(o)0(f)-327.5(p)0(e)15.1(r)0(i)17.3(o)0(d)21.2(i)0(c)-328.7(c)0(l)18.5(i)0(n)18.9(i)0(c)18.4(a)0(l)-328.7(e)0(x)15.1(a)0(m)17.7(i)0(n)18.9(a)0(t)18.4(i)0(o)18.9(n)0(s)-327.1(a)0(n)15.1(d)-336.5(m)13.2(e)0(a)14.7(s)0(u)20(r)0(e)13.5(-)]TJ
0 -1.0471 TD
[(me)17.7(nt)-294.1(of)-293.3(le)18.4(ng)15.5(th)18.9(,)-302(w)0(e)16.9(i)0(g)18.9(h)0(t)-294.1(a)0(n)15.1(d)-302.4(bl)18.9(oo)15.5(d)-302.4(p)0(r)19.6(e)0(s)19.6(s)0(u)14.4(r)0(e)-293.7(u)0(s)20(i)0(n)18.9(g)-302.4(st)17.7(an)15.1(da)15.1(rd)]TJ
0 -1.0528 TD
[(me)17.7(as)14(ur)19.6(em)17.7(en)15.1(t)-304.7(d)0(e)20.8(v)0(i)13.2(c)0(e)20.4(s)-309.2(ap)20.8(pr)19.6(op)15.5(ri)17.3(at)18.4(e)-308.5(f)0(o)19.6(r)-304(in)13.2(fa)19.2(nt)18.9(s.)-298.2(C)11.6(r)0(o)13.9(w)0(n)17.3(\261)0(h)21.2(e)0(e)14.7(l)]TJ
0 -1.0471 TD
[(le)18.4(ng)15.5(th)-242.9(wa)16.9(s)-252.3(m)0(e)17.7(a)0(s)13.9(u)0(r)19.6(e)0(d)-246.6(b)0(y)-240.5(t)0(w)14.9(o)-251.2(pe)15.1(rs)18.4(on)15.5(s)-252.3(\()0(J)18.4(.)0(Y)142.9(.)0(W)100.1(.)-250.8(W)77.7(o)0(n)21.2(g)-251.2(an)15.1(d)-251.2(S)0(.)]TJ
25.1977 66.1583 TD
[(Mo)13.6(on)21.2(\))-269.8(u)0(s)20(i)0(n)18.9(g)-262.5(a)-268.6(s)0(t)17.7(a)0(d)20.8(i)0(o)13.2(m)0(e)17.7(t)0(e)18.4(r)60.2(.)-262.1(T)69.1(wo)-255.8(re)19.2(co)15.1(rd)19.6(in)13.2(gs)-253.1(wi)14.9(th)18.9(in)-254.3(0.)15.9(5)-262.5(c)0(m)]TJ
0 -1.0471 TD
[(of)-208(ea)14.7(ch)-201.1(ot)13.2(he)20.8(r)-212.9(w)0(e)11.2(r)0(e)-202.7(a)0(c)14.7(c)0(e)20.4(p)0(t)18.9(e)0(d)-206.8(a)0(n)15.1(d)-211.3(th)13.2(e)-211.7(m)0(e)17.7(a)0(n)-206.8(v)0(a)15.1(l)0(u)18.9(e)-211.7(ca)14.7(lc)18.5(ul)18.9(at)12.8(ed)20.8(.)]TJ
0 -1.0528 TD
[(Co)16.5(rt)17.3(is)17.7(ol)13.2(/c)18.4(re)19.2(at)18.4(in)13.2(in)18.8(e)-342.6(r)0(a)13.5(t)0(i)16.5(o)0(s)-332.8(w)0(e)16.9(r)0(e)-339.3(m)0(e)17.7(a)0(s)19.6(u)0(r)13.9(e)0(d)-337.7(i)13.9(n)-347.9(t)0(h)18.9(e)-348.3(ur)19.6(in)18.8(e)-348.3(c)0(o)20.8(l)0(-)]TJ
0 -1.0471 TD
[(le)12.8(ct)18.5(ed)-303.5(ov)21.2(er)13.5(ni)18.9(gh)21.2(t)-316.1(a)0(t)-300.2(e)0(a)14.7(c)0(h)-297.8(v)0(i)13.2(s)0(i)17.7(t)-310.4(du)21.2(ri)17.3(ng)-303.1(th)18.9(e)-314.2(t)0(r)17.3(e)0(a)14.7(t)0(m)21.4(e)0(n)15.1(t)-310.4(pe)15.1(ri)17.3(od)21.2(;)]TJ
0 -1.0528 TD
[(th)13.2(e)-319.8(r)0(e)13.5(s)0(u)20(l)0(t)16.5(s)-326.3(w)12.4(i)0(l)16.5(l)-327.5(be)-314.9(re)19.2(po)15.5(rt)17.3(ed)-314.9(se)19.6(pa)15.1(ra)19.2(te)18.4(ly)75.8(.)]TJ
/F5 1 Tf
0 -2.4526 TD
[(Hom)-10.2(e)-331.2(monitor)-9.5(ing)]TJ
/F6 1 Tf
1.0015 -1.7527 TD
[(Th)17.1(e)-285.7(N)12.4(el)12.8(lc)18.4(or)31(-3)13.9(00)21.2(0)-279.6(p)0(u)15.5(l)0(s)17.7(e)-280(ox)15.5(im)15.7(et)18.5(er)-271(\(N)15.7(el)18.4(lc)12.8(or)-270.6(P)11.4(u)0(r)13.9(i)0(t)16.5(a)0(n)-269.4(B)0(e)16.1(n)0(-)]TJ
-1.0015 -1.0471 TD
[(ne)15.1(tt)16.5(,)-233.7(P)11.4(le)18.4(as)13.9(an)20.8(to)18.9(n,)-228.8(C)11.6(A)0(,)-227(U)0(S)18.1(A)0(\))-223.3(w)0(a)16.9(s)-235.3(us)14.4(ed)-223.9(to)-220.2(mo)12.4(ni)18.9(to)18.8(r)-235.7(o)0(v)21.2(e)0(r)13.5(n)0(i)18.9(g)0(h)21.2(t)]TJ
0 -1.0527 TD
[(ar)13.5(te)18.4(ri)17.3(al)-482.3(ox)15.5(yg)15.5(en)-479.9(sa)14(tu)18.8(ra)19.2(ti)16.5(on)-485.2(\()]TJ
/F5 1 Tf
11.2047 0 TD
(S)Tj
/F6 1 Tf
7.97 0 0 7.97 425.82 666.992 Tm
[(a,)18.4(O)]TJ
7.472 0 0 6.641 436.762 665.348 Tm
(2)Tj
9.963 0 0 9.963 440.39 666.992 Tm
[(\).)-486.4(An)-483.5(on)15.5(-l)17.3(in)18.9(e)-490.6(n)0(o)15.5(t)0(e)18.5(b)0(o)15.5(o)0(k)]TJ
-13.1566 -1.0471 TD
[(co)15.1(mp)18.1(ut)18.9(er)-396.2(us)14.4(i)13.9(n)0(g)-394.2(t)0(h)13.2(e)-399.5(Sa)15.9(tM)16.9(as)19.6(te)12.8(r)-400.7(p)0(r)19.6(o)0(g)15.5(r)0(a)19.2(m)0(m)14.9(e)-405.2(\(E)15.5(MG)-394.4(S)11.4(c)0(i)12.8(e)0(n)20.8(-)]TJ
0 -1.0527 TD
[(ti)16.5(fi)17.3(c,)-280.4(B)11.6(e)0(v)15.1(e)0(r)19.2(l)0(y)-282.7(H)12.4(il)16.5(ls)17.7(,)-290.6(C)11.6(A,)-278.2(US)18.1(A\))-280.2(ca)14.7(pt)18.9(ur)19.6(ed)-280.8(be)15.1(at)18.4(-t)17.3(o-)19.6(be)15.1(at)]TJ
/F5 1 Tf
20.8388 0 TD
(S)Tj
/F6 1 Tf
7.97 0 0 7.97 521.801 646.072 Tm
[(a,)18.4(O)]TJ
7.472 0 0 6.641 532.743 644.428 Tm
(2)Tj
9.963 0 0 9.963 309.316 635.584 Tm
[(an)15.1(d)-461.7(p)0(u)15.5(l)0(s)17.7(e)-462.1(ra)13.5(te)-453.9(da)15.1(ta)18.4(.)-461.3(A)-465.6(di)18.9(sp)14.4(os)20(ab)15.1(le)-453.9(Ne)16.9(ll)16.5(co)15.1(r)-463.3(O)0(x)17.3(i)0(s)17.7(e)0(n)20.8(s)0(o)14.4(r)-463.3(II)]TJ
0 -1.0471 TD
[(st)17.7(er)13.5(il)16.5(e)-467.8(s)0(i)12(n)0(g)21.2(l)0(e)18.4(-)0(u)13.9(s)0(e)-464.1(N)12.4(-2)13.9(5)-473.1(o)0(x)21.2(i)0(m)15.7(e)0(t)18.5(e)0(r)-464.5(p)0(r)19.6(o)0(b)15.5(e)-473.5(\(N)15.7(el)18.5(lc)18.4(or)-464.1(P)11.4(u)0(r)13.9(i)0(t)16.5(a)0(n)]TJ
0 -1.0528 TD
[(Be)16.1(nn)15.5(et)18.4(t\))-341.3(w)12.4(a)0(s)-338.9(a)0(t)18.5(t)0(a)12.8(c)0(h)20.8(e)0(d)-337.7(t)0(o)-339.7(t)0(h)18.9(e)-348.3(in)18.9(fa)19.2(nt)]TJ
/F4 1 Tf
14.0272 0 TD
(')Tj
/F6 1 Tf
0.2049 0 TD
[(s)-349.1(b)0(i)18.9(g)-347.9(to)18.9(e)-348.3(i)0(n)-334(t)0(h)13.2(e)-342.6(af)13.5(te)18.5(r)20.4(-)]TJ
-14.2321 -1.0471 TD
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0 -1.0528 TD
[(pu)15.5(ls)17.7(e)-462.1(o)0(x)15.5(i)0(m)15.7(e)0(t)18.4(r)0(y)]TJ
/F5 1 Tf
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/F6 1 Tf
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0 -1.0471 TD
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(a,O)Tj
7.472 0 0 6.641 506.154 529.342 Tm
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9.963 0 0 9.963 512.901 530.986 Tm
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1.0015 -1.0528 TD
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0 -1.0527 TD
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0 -1.0471 TD
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0 -1.0528 TD
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/F11 1 Tf
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($)Tj
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0.8251 0 TD
[(10)-331.6(s)]TJ
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[(si)17.7(le)12.8(nc)20.8(e)-217.4(b)0(e)15.1(f)0(o)19.6(r)0(e)-208.4(a)0(n)15.1(d)-217(af)19.2(te)12.8(r)43.2(,)-216.6(re)13.5(po)21.2(rt)17.3(ed)-206.8(as)-213.7(ev)20.8(en)15.1(ts)-210(or)-208(ep)20.8(is)17.7(od)15.5(es)]TJ
/F12 1 Tf
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(.)Tj
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(h)Tj
7.472 0 0 6.641 525.77 462.217 Tm
(-1)Tj
9.963 0 0 9.963 531.723 457.795 Tm
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/F5 1 Tf
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[(Infan)-7.8(t)-333.2(lung)-341.2(function)]TJ
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1.0015 -1.747 TD
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0 -1.0471 TD
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0 -1.0527 TD
[(in)13.2(fa)19.2(nt)-413.6(ex)20.8(am)17.7(in)13.2(ed)20.8(.)]TJ
/F5 1 Tf
7.1303 0 TD
(S)Tj
/F6 1 Tf
7.97 0 0 7.97 385.228 384.491 Tm
[(a,)18.4(O)]TJ
7.472 0 0 6.641 396.17 382.847 Tm
(2)Tj
9.963 0 0 9.963 404.05 384.491 Tm
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/F5 1 Tf
20.8388 0 TD
(S)Tj
/F6 1 Tf
7.97 0 0 7.97 521.801 374.06 Tm
[(a,)18.4(O)]TJ
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(2)Tj
/F10 1 Tf
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/F6 1 Tf
0.5463 0 TD
[(95)21.2(%\))11.6(.)-296.3(I)0(n)13.9(f)0(a)19.2(n)0(t)18.9(s)-303.6(we)16.9(re)-293.8(th)18.9(en)-292.1(se)19.6(da)15.1(te)18.5(d)-302.4(w)0(i)14.9(t)0(h)-288.4(c)0(h)15.1(l)0(o)18.9(r)0(a)19.2(l)-304.7(hy)21.2(dr)14(at)18.4(e)-302.8(u)0(p)]TJ
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/F12 1 Tf
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(.)Tj
/F6 1 Tf
0.2731 -0.1992 TD
[(kg)-331.6(bo)15.5(dy)-331.6(we)16.9(ig)18.8(ht)]TJ
7.472 0 0 6.641 456.038 357.562 Tm
(-1)Tj
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0 -1.0471 TD
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7.97 0 0 7.97 517.946 332.22 Tm
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[(pl)-16.7(et)-16.7(h)]TJ
9.963 0 0 9.963 533.253 332.22 Tm
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(\))Tj
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[(an)15.1(d)-199.9(a)0(i)18.5(r)0(w)15.7(a)0(y)20.8(s)-201.1(re)19.2(si)17.7(st)17.7(an)15.1(ce)-190.1(\()]TJ
/F5 1 Tf
9.1504 0 TD
(R)Tj
/F6 1 Tf
7.97 0 0 7.97 406.375 321.732 Tm
(aw)Tj
9.963 0 0 9.963 415.446 321.732 Tm
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-10.6527 -1.0471 TD
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[(fa)13.5(ce)-286.9(ma)17.7(sk)-292.9(an)20.8(d)-296.7(p)0(n)15.5(e)0(u)15.1(m)0(o)18.1(t)0(a)18.4(c)0(h)15.1(o)0(g)21.2(r)0(a)19.2(p)0(h)15.5(,)-296.3(wh)17.3(ic)18.4(h)-302.4(w)12.4(as)-293.3(at)18.4(ta)18.5(ch)15.1(ed)-286.5(to)]TJ
0 -1.0527 TD
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0 -1.0471 TD
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0 -1.0528 TD
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0 -1.0471 TD
[(hu)15.5(mi)15.7(di)18.9(fi)17.3(ed)-258(ai)12.8(r)-264.1(f)0(r)12.4(o)0(m)-255.1(a)-268.6(re)13.5(br)19.6(ea)14.7(th)18.9(in)18.9(g)-268.2(b)0(a)15.1(g)-268.2(as)]TJ
/F5 1 Tf
16.1213 0 TD
(R)Tj
/F6 1 Tf
7.97 0 0 7.97 475.823 269.461 Tm
(aw)Tj
9.963 0 0 9.963 487.616 269.461 Tm
[(wa)16.9(s)-269.4(m)0(e)17.7(a)0(s)13.9(u)0(r)31(-)]TJ
-17.8968 -1.0527 TD
[(ed)15.1(.)-148.3(T)0(h)17.1(e)0(s)13.9(e)-149.1(va)20.8(lv)13.2(es)-139.7(co)15.1(ul)18.9(d)-148.7(a)0(l)18.4(s)0(o)-145(b)0(e)-138.5(c)0(l)12.8(o)0(s)20(e)0(d)-138.5(s)0(i)12(m)13.2(ul)13.2(ta)18.4(ne)20.8(ou)15.5(sl)17.7(y)-148.7(a)0(t)-146.6(e)0(n)20.8(d)0(-)]TJ
0 -1.0471 TD
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0 -1.0528 TD
[(me)12(as)19.6(ur)19.6(em)12(en)20.8(t)-219.4(o)0(f)-208(F)0(R)17.3(C)]TJ
7.97 0 0 7.97 391.918 238.053 Tm
[(pl)23.1(et)17(h)]TJ
9.963 0 0 9.963 407.282 238.053 Tm
[(.)-216.6(W)0(h)20.1(e)0(r)13.5(e)-217.4(po)21.2(ss)13.2(ib)18.9(le)18.4(,)-216.6(f)0(i)17.3(v)0(e)-212.5(o)0(r)-208(s)0(i)17.7(x)-217(te)12.8(ch)20.8(-)]TJ
-9.8333 -1.0527 TD
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/F5 1 Tf
16.1043 0 TD
(R)Tj
/F6 1 Tf
7.97 0 0 7.97 475.653 227.565 Tm
(aw)Tj
9.963 0 0 9.963 486.595 227.565 Tm
[(an)15.1(d)-182.9(F)11.4(RC)]TJ
7.97 0 0 7.97 521.121 227.565 Tm
-0.0159 Tc
[(pl)-15.9(eth)]TJ
9.963 0 0 9.963 309.316 217.134 Tm
0 Tc
[(we)16.9(re)-430.3(ma)17.7(de)-428.7(ac)14.7(co)20.8(rd)13.9(in)18.9(g)-433.3(t)0(o)-430.7(a)-433.7(pr)13.9(ed)20.8(et)12.8(er)19.2(mi)15.7(ne)20.8(d)-438.9(p)0(r)19.6(o)0(t)18.9(o)0(c)15.1(o)0(l)-425([)0(3)14(8].)]TJ
0 -1.0527 TD
[(Ai)-7.8(rways)-392.2(conductanc)-11.6(e)-382.4(\()]TJ
/F5 1 Tf
9.4235 0 TD
(G)Tj
/F6 1 Tf
7.97 0 0 7.97 410.343 206.646 Tm
(aw)Tj
9.963 0 0 9.963 419.584 206.646 Tm
[(\),)-384(the)-386.3(recip)-8.6(rocal)-389.9(of)]TJ
/F5 1 Tf
8.092 0 TD
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/F6 1 Tf
7.97 0 0 7.97 506.211 206.646 Tm
(aw)Tj
9.963 0 0 9.963 514.771 206.646 Tm
[(,)-387.3(was)]TJ
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[(calcul)-10.6(ated)-256.6(and)-258.8(the)-255.5(values)-259.3(of)-253.5(FRC)]TJ
7.97 0 0 7.97 440.561 196.214 Tm
(pleth)Tj
9.963 0 0 9.963 458.816 196.214 Tm
(and)Tj
/F5 1 Tf
1.6958 0 TD
(G)Tj
/F6 1 Tf
7.97 0 0 7.97 482.853 196.214 Tm
(aw)Tj
9.963 0 0 9.963 494.589 196.214 Tm
[(were)-254.1(co)-7.6(m-)]TJ
-18.5967 -1.0527 TD
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0 -1.0471 TD
[(lengt)-9(h.)]TJ
1.0015 -1.0528 TD
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[(as)19.6(se)13.9(ss)18.9(ed)-388.9(be)20.8(tw)14.9(ee)20.4(n)-399.1(c)0(o)20.8(n)0(s)14.4(e)0(c)20.4(u)0(t)13.2(i)13.9(ve)-388.9(ho)15.5(me)-386.3(mo)18.1(ni)18.9(to)13.2(ri)17.3(ng)-382.8(vi)13.2(si)17.7(t)13.9(s)-400.3(to)]TJ
T*
[(th)18.9(e)-348.3(h)0(o)21.2(m)0(e)-340.8(v)0(i)18.9(s)0(i)17.7(t)-344.6(of)-333.2(in)13.2(t)13.9(e)0(r)13.5(e)0(s)19.6(t)0(.)-339.3(T)12.2(he)-337.7(AU)19.1(C)-346.9(b)0(e)15.1(t)0(w)20.6(e)0(e)14.7(n)-342.2(vi)13.2(si)17.7(t)-344.6(1)-342.2(an)15.1(d)]TJ
T*
[(vi)18.9(si)17.7(t)-407.2(4)-404.8(\(t)17.3(he)-400.3(en)20.8(d)-410.5(o)0(f)-395.8(t)0(h)18.9(e)-405.2(12)15.5(-w)15.7(ee)20.4(k)-410.5(i)13.9(nh)15.5(al)18.4(ed)-400.3(th)18.9(er)19.2(ap)15.1(y\))-395.8(is)-397.7(re)13.5(p-)]TJ
T*
[(re)19.2(se)13.9(nt)18.9(ed)-314.9(by)15.5(:)]TJ
/F13 1 Tf
0.6089 -2.1453 TD
[(AU)15.7(C)]TJ
/F14 1 Tf
2.5778 0 TD
(\210)Tj
ET
1 i 
100.46 304.327 178.866 -0.397 re
f*
BT
/F13 1 Tf
9.963 0 0 9.963 100.46 308.409 Tm
(d)Tj
6.974 0 0 6.974 105.902 308.636 Tm
(2)Tj
/F14 1 Tf
9.963 0 0 9.963 109.871 308.409 Tm
(\205)Tj
/F13 1 Tf
0.387 0 TD
(C)Tj
6.974 0 0 6.974 120.869 308.636 Tm
(2)Tj
/F14 1 Tf
9.963 0 0 9.963 127.105 308.409 Tm
(\207)Tj
/F13 1 Tf
0.9958 0 TD
(C)Tj
6.974 0 0 6.974 144.17 308.636 Tm
(1)Tj
/F14 1 Tf
9.963 0 0 9.963 148.195 308.409 Tm
0.2182 Tc
(\206\207)Tj
/F13 1 Tf
1.599 0 TD
0 Tc
(d)Tj
6.974 0 0 6.974 169.568 308.636 Tm
(3)Tj
/F14 1 Tf
9.963 0 0 9.963 173.537 308.409 Tm
(\205)Tj
/F13 1 Tf
0.387 0 TD
(C)Tj
6.974 0 0 6.974 184.535 308.636 Tm
(2)Tj
/F14 1 Tf
9.963 0 0 9.963 190.772 308.409 Tm
(\207)Tj
/F13 1 Tf
0.9958 0 TD
(C)Tj
6.974 0 0 6.974 207.836 308.636 Tm
(3)Tj
/F14 1 Tf
9.963 0 0 9.963 211.861 308.409 Tm
0.2182 Tc
(\206\207)Tj
/F13 1 Tf
1.599 0 TD
0 Tc
(d)Tj
6.974 0 0 6.974 233.235 308.636 Tm
(4)Tj
/F14 1 Tf
9.963 0 0 9.963 237.203 308.409 Tm
(\205)Tj
/F13 1 Tf
0.387 0 TD
(C)Tj
6.974 0 0 6.974 248.202 308.636 Tm
(3)Tj
/F14 1 Tf
9.963 0 0 9.963 254.438 308.409 Tm
(\207)Tj
/F13 1 Tf
0.9958 0 TD
(C)Tj
6.974 0 0 6.974 271.502 308.636 Tm
(4)Tj
/F14 1 Tf
9.963 0 0 9.963 275.527 308.409 Tm
(\206)Tj
/F13 1 Tf
-9.3097 -1.3657 TD
(2d)Tj
6.974 0 0 6.974 193.039 295.03 Tm
(1)Tj
/F6 1 Tf
9.963 0 0 9.963 58.28 282.104 Tm
[(wh)17.3(er)19.2(e)-410.9(C)-409.5(i)13.9(s)-411.7(th)18.9(e)-405.2(c)0(h)15.1(a)0(n)20.8(g)0(e)-400.3(i)0(n)-396.6(c)0(o)15.1(u)0(g)21.2(h)-410.5(ra)19.2(te)-397(\(e)13.5(ve)20.8(nt)13.2(s)]TJ
/F12 1 Tf
18.3008 0.1992 TD
(.)Tj
/F6 1 Tf
0.2675 -0.1992 TD
(h)Tj
7.472 0 0 6.641 248.202 286.526 Tm
(-1)Tj
9.963 0 0 9.963 258.293 282.104 Tm
[(or)-395.8(ep)15.1(i-)]TJ
-20.0763 -1.0641 TD
[(so)20(de)15.1(s)]TJ
/F12 1 Tf
2.1624 0.1992 TD
(.)Tj
/F6 1 Tf
0.2731 -0.1992 TD
(h)Tj
7.472 0 0 6.641 87.42 275.924 Tm
(-1)Tj
9.963 0 0 9.963 93.373 271.502 Tm
[(\),)-270.2(C)]TJ
7.97 0 0 7.97 108.34 271.502 Tm
(1)Tj
9.963 0 0 9.963 115.143 271.502 Tm
-0.0165 Tc
[(t)-16.5(h)2.4(e)-296.5(c)-16.5(ha)-16.5(n)4.3(g)-16.5(e)-291.6(f)-16.5(ro)-16.5(m)-288.6(b)-16.5(as)-16.5(el)-16.5(in)-16.5(e)-285.9(a)-16.5(t)-288.3(v)-16.5(is)-16.5(it)-298.5(1)-296.1(\()]TJ
/F10 1 Tf
14.1581 0 TD
0 Tc
(=)Tj
/F6 1 Tf
0.5406 0 TD
[(0\))14(,)-279.2(C)]TJ
7.97 0 0 7.97 281.48 271.502 Tm
(2)Tj
9.963 0 0 9.963 58.28 260.901 Tm
-0.017 Tc
[(t)-17(h)1.9(e)-393.7(c)-17(ha)-17(ng)-17(e)-383.1(f)-17(ro)-17(m)-385.9(b)-17(as)-17(el)-17(in)-17(e)-388.8(a)-17(t)-385.5(v)-17(is)-17(it)-395.7(2)-17(,)-382.3(C)]TJ
7.97 0 0 7.97 211.918 260.901 Tm
0 Tc
(3)Tj
9.963 0 0 9.963 219.628 260.901 Tm
[(th)13.2(e)-376.7(c)0(h)20.8(a)0(n)15.1(g)0(e)-366.1(f)0(r)12.4(o)0(m)]TJ
-16.1953 -1.0641 TD
[(ba)15.1(se)19.6(li)16.5(ne)-195.4(at)-197.8(vi)18.9(si)17.7(t)-202.3(3)0(,)-200.3(C)]TJ
7.97 0 0 7.97 135.496 250.299 Tm
(4)Tj
9.963 0 0 9.963 141.505 250.299 Tm
[(th)13.2(e)-206(c)0(h)20.8(a)0(n)15.1(g)0(e)-195.4(f)0(r)18(o)0(m)-198.2(b)0(a)20.8(s)0(e)13.9(l)0(i)16.5(n)0(e)-195.4(a)0(t)-192.1(v)0(i)13.2(s)0(i)17.7(t)-202.3(4,)-194.6(d)]TJ
7.97 0 0 7.97 281.48 250.299 Tm
(2)Tj
9.963 0 0 9.963 58.28 239.698 Tm
[(th)18.9(e)-274.3(n)0(u)15.5(m)0(b)18.1(e)0(r)-265.3(o)0(f)-264.9(d)0(a)20.8(y)0(s)-264.5(b)0(e)15.1(t)0(w)14.9(e)0(e)20.4(n)-273.9(vi)18.9(si)17.7(ts)-266.9(1)-273.9(a)0(n)20.8(d)-273.9(2,)-262.9(d)]TJ
7.97 0 0 7.97 234.368 239.698 Tm
(3)Tj
9.963 0 0 9.963 241.115 239.698 Tm
[(th)18.9(e)-274.3(n)0(u)21.2(m)0(b)12.4(e)0(r)]TJ
-18.352 -1.0641 TD
[(of)-407.2(da)15.1(ys)-406.7(be)20.8(tw)14.9(ee)20.4(n)-416.2(v)0(i)18.9(s)0(i)17.7(t)0(s)-409.1(2)-416.2(an)15.1(d)-410.5(3)0(,)-410.9(d)]TJ
7.97 0 0 7.97 197.291 229.096 Tm
(4)Tj
9.963 0 0 9.963 205.398 229.096 Tm
[(th)18.9(e)-416.6(n)0(u)15.5(m)0(b)18.1(e)0(r)-407.6(o)0(f)-407.2(d)0(a)20.8(y)0(s)]TJ
-14.767 -1.0698 TD
[(be)15.1(tw)20.6(ee)14.7(n)-228.4(v)0(i)18.9(s)0(i)17.7(t)0(s)-221.3(3)-228.4(an)20.8(d)-228.4(4)0(,)-223.1(a)0(n)20.8(d)-228.4(d)]TJ
7.97 0 0 7.97 170.135 218.438 Tm
(1)Tj
9.963 0 0 9.963 176.372 218.438 Tm
[(th)18.9(e)-228.8(n)0(u)15.5(m)0(b)18.1(e)0(r)-219.8(o)0(f)-219.4(d)0(a)15.1(y)0(s)-219(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)]TJ
-11.8534 -1.0641 TD
[(vi)18.9(si)17.7(ts)-318.1(1)-325.1(a)0(n)20.8(d)-325.1(4.)]TJ
1.0015 -1.0471 TD
[(Fo)16.3(r)-395(e)0(a)14.7(c)0(h)-388.9(i)0(n)18.9(f)0(a)13.5(n)0(t)18.9(,)-398.7(th)18.9(e)-399.5(W)0(M)18.1(C)-398.1(is)-392.1(eq)20.8(ua)15.1(l)-395.8(t)0(o)-390.9(t)0(h)18.9(e)-399.5(su)20(m)-402.3(o)0(f)-390.1(a)0(l)18.5(l)]TJ
-1.0015 -1.0641 TD
[(AU)13.4(C)11.6(s)-269.4(of)-259.2(in)13.2(te)18.4(re)19.2(st)-261.2(di)18.9(vi)18.9(de)15.1(d)-268.2(b)0(y)-263.3(t)13.9(he)-263.7(ti)16.5(me)-261.2(fr)18(om)-260.7(ba)15.1(se)19.6(li)16.5(ne)-258(\(w)15.7(ee)14.7(k)]TJ
T*
[(0\))-373(re)13.5(co)20.8(rd)13.9(in)18.9(g)-382(t)0(o)-373.8(t)0(h)13.2(e)-382.4(en)20.8(d)-387.7(o)0(f)-373(t)0(h)18.9(e)-388.1(3-)19.6(mo)18.1(nt)18.9(h)-387.7(t)0(r)17.3(e)0(a)20.4(t)0(m)15.7(e)0(n)15.1(t)-384.4(pe)20.8(ri)17.3(od)]TJ
0 -1.0698 TD
[(\(w)15.7(ee)20.4(k)-308.1(1)0(2)21.2(\))0(.)-298.6(T)0(h)17.1(e)-302.8(sa)13.9(me)-295.3(ca)14.7(lc)18.4(ul)18.9(at)18.4(io)18.9(n)-308.1(w)0(a)16.9(s)-303.6(re)13.5(pe)20.8(at)18.5(ed)-297.8(fo)19.6(r)-309.7(t)0(h)18.8(e)-302.8(pe)15.1(-)]TJ
0 -1.0641 TD
[(ri)17.3(od)-240.5(fr)12.4(om)-238(ba)15.1(se)19.6(li)16.5(ne)-246.6(un)21.2(ti)16.5(l)-253.5(6)-251.2(mo)18.1(nt)18.9(hs)-241.7(af)13.5(t)13.9(e)0(r)-248.2(s)0(t)17.7(o)0(p)21.2(p)0(i)18.9(n)0(g)-246.2(t)0(r)17.3(e)0(a)20.4(t)0(m)15.7(e)0(n)15.1(t)0(.)]TJ
T*
[(Al)14.9(th)18.9(ou)15.5(gh)-473.8(al)12.8(l)-486.8(i)0(n)18.9(f)0(a)19.2(n)0(t)13.2(s)-485.7(we)16.9(re)-481.5(fo)19.6(ll)16.5(ow)17.3(ed)-479.9(fo)19.6(r)-491.7(9)-484.5(mo)18.1(nt)13.2(hs)-475(af)13.5(te)18.4(r)]TJ
T*
[(tr)17.3(ea)14.7(tm)21.4(en)15.1(t)-407.2(c)0(e)20.4(a)0(s)13.9(e)0(d)20.8(,)-404.4(th)13.2(e)-405.2(c)0(o)20.8(u)0(g)15.5(h)-404.8(da)15.1(ta)-397(fo)19.6(r)-406.4(t)0(h)18.9(e)-405.2(fi)11.6(na)20.8(l)-407.2(3)-404.8(mo)18.1(nt)13.2(hs)]TJ
T*
[(we)16.9(re)-470.2(no)15.5(t)-475.5(a)0(n)15.1(a)0(l)18.4(y)0(s)20(e)0(d)-474.3(t)0(o)-470.5(a)0(v)20.8(o)0(i)18.9(d)-478.8(co)15.1(nf)19.6(ou)15.5(nd)21.2(in)13.2(g)-473.1(e)0(f)24.9(f)0(e)19.2(c)0(t)12.8(s)-474.3(of)-469.7(th)13.2(e)]TJ
T*
[(se)19.6(co)15.1(nd)-314.5(br)19.6(on)15.5(ch)15.1(i)13.9(o)0(l)13.2(i)0(t)16.5(i)13.9(s)-326.3(s)0(e)19.6(a)0(s)13.9(o)0(n)21.2(.)]TJ
26.1993 66.1583 TD
[(Th)17.1(e)-342.6(p)0(r)19.6(o)0(p)15.5(o)0(r)19.6(t)0(i)16.5(o)0(n)-325.9(o)0(f)-333.2(d)0(a)20.8(y)0(s)-327.1(o)0(n)-331.6(w)0(h)17.3(i)0(c)18.4(h)-336.5(ea)14.7(ch)-326.3(sy)14.3(mp)18.1(to)18.8(m)-339.7(s)0(c)13.9(o)0(r)19.6(e)]TJ
-1.0015 -1.0471 TD
-0.0197 Tc
[(w)-19.7(a)-2.8(s)-528.1(p)-19.7(re)-19.7(s)-5.8(e)-19.7(nt)-523.6(w)-19.7(a)-8.5(s)-522.4(e)-19.7(x)-4.6(a)-19.7(mi)-19.7(ne)-19.7(d)-4.6(.)-520.9(T)-19.7(h)-2.6(e)-527.3(p)-19.7(er)-19.7(c)-6.2(e)-19.7(nt)-19.7(ag)-19.7(e)-516.7(o)-19.7(f)-517.9(e)-19.7(nt)-19.7(e)-6.9(r)-19.7(ed)]TJ
0 -1.0528 TD
0 Tc
[(di)13.2(ar)19.2(y)-416.2(d)0(a)15.1(y)0(s)-412.4(w)12.4(it)16.5(h)-421.9(s)0(y)20(m)0(p)18.1(t)0(o)18.8(m)-425(sc)19.6(or)19.6(es)-412.8(of)-407.2(0,)-410.9(1,)-410.9(2)-416.2(a)0(n)15.1(d)-416.2(3)-421.9(w)0(e)16.9(r)0(e)]TJ
0 -1.0471 TD
[(ca)14.7(lc)18.4(ul)18.9(at)12.8(ed)-263.7(fo)19.6(r)-275.5(e)0(a)20.4(c)0(h)-269.4(i)0(n)18.8(f)0(a)19.2(n)0(t)-265.7(d)0(u)15.5(r)0(i)17.3(n)0(g)-263.3(t)0(h)18.9(e)-274.3(tr)17.3(ea)20.4(tm)15.7(en)15.1(t)-270.6(p)0(e)15.1(r)0(i)17.3(o)0(d)15.5(,)-267.8(an)15.1(d)]TJ
0 -1.0528 TD
[(ex)15.1(pr)19.6(es)13.9(se)19.6(d)-387.7(a)0(s)-378.7(g)0(r)19.6(o)0(u)15.5(p)-387.7(me)17.7(di)18.8(an)-377.5(va)15.1(lu)18.8(es)-378.7(wi)14.9(th)-379.5(95)21.2(%)-390.1(c)0(o)15.1(n)0(f)19.6(i)0(d)18.9(e)0(n)15.1(c)0(e)]TJ
0 -1.0471 TD
[(in)13.2(te)18.4(rv)19.6(al)18.4(s.)-201.5(Di)14.9(f)20.4(f)0(e)13.5(r)0(e)19.2(n)0(c)15.1(e)0(s)-202.3(b)0(e)20.8(t)0(w)14.9(e)0(e)14.7(n)-205.6(gr)13.9(ou)21.2(ps)-201.9(we)16.9(re)-202.7(as)13.9(se)19.6(ss)18.8(ed)-206.8(by)-200.7(th)18.9(e)]TJ
0 -1.0528 TD
[(W)37.9(i)0(l)16.5(c)0(o)15.1(x)0(o)21.2(n)-473.1(te)18.4(st)17.7(.)-472.7(T)12.2(he)-462.9(Bo)16.5(nf)19.6(er)13.5(ro)19.6(ni)-464.8(co)20.8(rr)18(ec)14.7(ti)16.5(on)-462.5(w)12.4(a)0(s)-464.1(m)0(a)17.7(d)0(e)-462.9(t)0(o)]TJ
0 -1.0471 TD
[(ad)15.1(ju)18.8(st)-318.1(fo)19.6(r)-326.7(m)0(u)18.1(l)0(t)16.5(i)0(p)18.9(l)0(e)-317.3(t)0(e)18.4(s)0(t)17.7(i)0(n)18.9(g)-325.1([4)19.6(1].)]TJ
/F5 1 Tf
1.0015 -1.0527 TD
(S)Tj
/F6 1 Tf
7.97 0 0 7.97 324.227 687.968 Tm
[(a,)25.5(O)]TJ
7.472 0 0 6.641 335.168 686.324 Tm
(2)Tj
9.963 0 0 9.963 342.142 687.968 Tm
[(da)15.1(ta)-317.3(we)16.9(re)-322.2(an)15.1(al)18.5(ys)20(ed)-320.6(by)-320.2(ca)14.7(lc)18.4(ul)18.9(at)18.4(in)13.2(g)-325.1(t)0(h)18.9(e)-331.2(pe)15.1(rc)19.2(en)15.1(t)13.9(a)0(g)15.1(e)]TJ
-3.2948 -1.0527 TD
(of)Tj
/F5 1 Tf
1.0926 0 TD
(S)Tj
/F6 1 Tf
7.97 0 0 7.97 325.134 677.48 Tm
[(a,)25.5(O)]TJ
7.472 0 0 6.641 336.076 675.836 Tm
(2)Tj
9.963 0 0 9.963 342.595 677.48 Tm
[(va)20.8(lu)18.8(es)-270.6(of)]TJ
/F10 1 Tf
3.8525 0 TD
(<)Tj
/F6 1 Tf
0.5463 0 TD
[(90)21.2(%)-282(a)0(n)15.1(d)]TJ
/F10 1 Tf
3.7842 0 TD
(<)Tj
/F6 1 Tf
0.5406 0 TD
[(94)15.5(%.)-271(S)11.4(i)0(n)18.8(c)0(e)-275.5(a)0(n)20.8(y)-279.6(di)18.9(f)14.7(f)0(e)19.2(r)0(e)19.2(n)0(c)15.1(e)0(s)]TJ
-12.064 -1.0471 TD
[(in)-254.3(ov)15.5(er)19.2(ni)13.2(gh)21.2(t)]TJ
/F5 1 Tf
5.0191 0 TD
(S)Tj
/F6 1 Tf
7.97 0 0 7.97 364.195 667.049 Tm
[(a,)18.4(O)]TJ
7.472 0 0 6.641 375.137 665.405 Tm
(2)Tj
9.963 0 0 9.963 381.487 667.049 Tm
[(we)16.9(re)-253.9(ex)15.1(pe)20.8(ct)12.8(ed)-252.3(to)-254.3(be)-252.3(pr)13.9(es)19.6(en)15.1(t)-259.2(e)0(a)14.7(r)0(l)17.3(y)-262.5(in)-254.3(th)18.9(e)]TJ
-7.2441 -1.0528 TD
[(st)17.7(ud)15.5(y)73.2(,)-262.1(th)18.8(e)-262.9(p)0(l)18.9(a)0(c)14.7(e)0(b)15.1(o)-256.8(an)15.1(d)-262.5(s)0(t)17.7(e)0(r)19.2(o)0(i)18.9(d)-262.5(gr)13.9(ou)21.2(ps)-253.1(we)16.9(re)-253.9(on)15.5(ly)-254.3(co)20.8(mp)18.1(ar)13.5(ed)]TJ
0 -1.0471 TD
[(du)15.5(ri)17.3(ng)-314.5(th)18.9(e)-325.5(f)0(i)17.3(r)0(s)18.4(t)-327.5(3)-325.1(w)12.4(ee)14.7(ks)20(.)]TJ
1.0015 -1.0527 TD
-0.0167 Tc
[(T)-16.7(h)0.4(e)-467.4(t)-16.7(wo)-16.7(-s)-16.7(id)-16.7(ed)-467(F)-5.3(i)-16.7(sh)-16.7(er)]TJ
/F4 1 Tf
8.6724 0 TD
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[(In)13.9(it)16.5(ia)18.4(ll)16.5(y)73.2(,)-210.9(be)15.1(fo)19.6(re)-202.7(th)13.2(e)-211.7(t)0(r)17.3(i)0(a)18.4(l)-213.7(in)18.9(ha)20.8(le)12.8(rs)-203.5(w)12.4(e)0(r)13.5(e)-211.7(is)17.7(su)20(ed)15.1(,)-210.9(t)0(h)18.8(e)-211.7(me)12(di)18.9(an)]TJ
-1.0015 -1.0471 TD
[(va)15.1(lu)18.8(es)-429.9(fo)19.6(r)-440.5(c)0(o)20.8(u)0(g)15.5(h)-433.3(ra)13.5(te)18.4(s)-434.4(\()0(F)14.7(P)11.4(:)-441.3(n)]TJ
/F10 1 Tf
12.1778 0 TD
(=)Tj
/F6 1 Tf
0.5406 0 TD
[(22)15.5(;)-435.6(p)0(l)18.9(a)0(c)14.7(e)0(b)15.1(o)0(:)-425(n)]TJ
/F10 1 Tf
5.9068 0 TD
(=)Tj
/F6 1 Tf
0.5463 0 TD
[(23)21.2(\))-440.5(w)0(e)16.9(r)0(e)]TJ
-19.1715 -1.0528 TD
[(si)17.7(mi)15.7(la)12.8(r:)-187.6(co)20.8(ug)15.5(h)-199.9(e)0(p)20.8(i)0(s)17.7(o)0(d)15.5(e)0(s)]TJ
/F12 1 Tf
9.0764 0.1992 TD
(.)Tj
/F6 1 Tf
0.2731 -0.1992 TD
(h)Tj
7.472 0 0 6.641 407.338 755.149 Tm
(-1)Tj
9.963 0 0 9.963 413.291 750.727 Tm
[(:)-196.6(F)0(P)-187.7(0)0(.)15.9(8)0(,)-188.9(p)0(l)18.9(a)0(c)14.7(e)0(b)20.8(o)-199.9(0.)21.6(6;)-191.7(an)20.8(d)-199.9(c)0(o)20.8(u)0(g)15.5(h)]TJ
-10.4365 -1.0471 TD
[(ev)15.1(en)15.1(t)13.9(s)]TJ
/F12 1 Tf
2.4811 0.1992 TD
(.)Tj
/F6 1 Tf
0.2675 -0.1992 TD
(h)Tj
7.472 0 0 6.641 341.631 744.718 Tm
-0.0185 Tc
(-1)Tj
9.963 0 0 9.963 347.584 740.296 Tm
0 Tc
[(:)-236.5(F)11.4(P)-239(3)0(.)15.9(5)0(,)-228.8(p)0(l)18.9(a)0(c)14.7(e)0(b)20.8(o)-239.8(3.)15.9(1.)-228.8(At)-229.8(th)18.9(e)-240.2(e)0(n)15.1(d)-234.1(of)-230.7(th)13.2(e)-234.5(t)0(r)17.3(e)0(a)14.7(t)0(m)15.7(e)0(n)20.8(t)]TJ
-3.8411 -1.0528 TD
[(pe)15.1(ri)17.3(od)15.5(,)-273.5(t)0(h)18.9(e)-280(m)13.2(e)0(d)15.1(i)0(a)18.4(n)-279.6(co)20.8(ug)15.5(h)-273.9(r)0(a)19.2(t)0(e)12.8(s)-275.1(\(F)20.4(P:)-270.6(n)]TJ
/F10 1 Tf
14.8239 0 TD
(=)Tj
/F6 1 Tf
0.5463 0 TD
[(18)21.2(;)-276.3(p)0(l)18.9(a)0(c)14.7(e)0(b)15.1(o)0(:)-265.7(n)]TJ
/F10 1 Tf
5.5824 0 TD
(=)Tj
/F6 1 Tf
0.5463 0 TD
[(19)21.2(\))]TJ
-21.4989 -1.0471 TD
[(we)16.9(re)13.5(:)-538.1(c)0(o)15.1(u)0(g)21.2(h)-541.4(ep)15.1(is)17.7(od)21.2(es)]TJ
/F12 1 Tf
8.9797 0.1992 TD
(.)Tj
/F6 1 Tf
0.2731 -0.1992 TD
(h)Tj
7.472 0 0 6.641 406.375 723.798 Tm
(-1)Tj
9.963 0 0 9.963 412.327 719.376 Tm
[(:)-538.1(F)0(P)-534.9(0)0(.)21.6(0)0(5)15.5(,)-541(pl)18.9(ac)20.4(eb)15.1(o)-541.4(0)0(.)21.6(1)0(0)15.5(;)-538.1(an)15.1(d)]TJ
-10.3397 -1.0528 TD
[(co)15.1(ug)15.5(h)-245.5(e)0(v)15.1(e)0(n)20.8(t)0(s)]TJ
/F12 1 Tf
5.1272 0.1992 TD
(.)Tj
/F6 1 Tf
0.2732 -0.1992 TD
(h)Tj
7.472 0 0 6.641 367.994 713.31 Tm
(-1)Tj
9.963 0 0 9.963 374.003 708.888 Tm
[(:)-247.8(F)11.4(P)-250.4(0)0(.)15.9(0)0(9)15.5(,)-245.1(pl)13.2(ac)20.4(eb)15.1(o)-251.2(0)0(.)21.6(2)0(2)15.5(,)-245.1(\()]TJ
6.974 0 0 6.974 472.479 708.888 Tm
0.0001 Tc
(NS)Tj
9.963 0 0 9.963 481.209 708.888 Tm
0 Tc
[(\).)-241.7(T)74.8(a)0(b)15.1(l)0(e)-237.6(2)-251.2(pre-)]TJ
-17.2537 -1.0471 TD
[(sents)-390.3(the)-380.7(cumul)-9.7(ative)-385(changes)-389(in)-379.5(cough)-385.5(rate)-383.4(for)-386.7(the)-380.7(pla-)]TJ
0 -1.0527 TD
[(ceb)-8.8(o)-342.2(and)-349.8(FP)-352.8(groups)-348.8(du)-7.2(ring)-348.5(the)-352.2(treatmen)-11.1(t)-344.6(and)-349.8(foll)-9.4(ow-up)]TJ
T*
[(perio)-8.2(ds)-292.9(\(up)-294.1(to)-294.1(36)-291.7(weeks\).)-297(Intergroup)-294(differences)-291.5(in)-294.1(over-)]TJ
0 -1.0471 TD
[(night)-287.4(cough)-283.1(episodes)-284.8(and)-281.5(events)-282.1(related)-286.1(to)-282.8(these)-281.3(changes)]TJ
0 -1.0528 TD
[(wer)-8.2(e)-285.7(u)-6.5(nremarkabl)-11.9(e,)-286.1(d)-6.5(uring)-292.3(both)-290(treatmen)-11.1(t)-293.4(and)-287.2(foll)-9.4(ow-up)]TJ
0 -1.0471 TD
[(perio)-8.2(ds,)-435.6(and)-429.5(only)-437.9(significant)-442.6(at)-431.1(36)-434(weeks)-436.5(\(p)]TJ
/F10 1 Tf
18.5967 0 TD
(=)Tj
/F6 1 Tf
0.552 0 TD
[(0.05\))-431.8(for)]TJ
-19.1487 -1.0527 TD
[(cou)-8.4(gh)-428.3(episo)-7.8(des.)-431.1(In)-435.6(table)-430.5(2,)-433.6(missin)-9.2(g)-427.6(data)-438.7(at)-431.1(12)-428.3(and)-435.2(36)]TJ
0 -1.0471 TD
[(week)-7.8(s)-354.8(were)-356.5(filled)-360.8(by)-348.7(extra)-8.6(polating)-360.8(previ)-8.2(ous)-350.6(visits)]TJ
/F4 1 Tf
20.3323 0 TD
(')Tj
/F6 1 Tf
0.5691 0 TD
(data.)Tj
-20.9014 -1.0527 TD
[(Pa)-6.8(tients)-275.1(with)-273.5(no)-274.7(data)-273.7(follow)-9.2(ing)-272.1(the)-272.5(basel)-8.2(ine)-272.5(cough)-271.7(recor-)]TJ
0 -1.0471 TD
[(dings)-326.1(wer)-8.2(e)-319.8(elimin)-9.6(ated)-324.9(from)-328.1(the)-323.7(analys)-9(is.)-318.5(The)-325.5(trend)-8.2(s)-320.6(and)]TJ
0 -1.0528 TD
[(p-val)-8.2(ues)-311.2(in)-305.5(table)-311(2)-308.1(were)-311(simil)-9.6(ar)-305.1(with)-313.3(or)-304.7(wi)-7.8(thout)-310.2(data)-307.8(ex-)]TJ
0 -1.0471 TD
[(trapo)-8.2(lation.)-251.5(Figure)-247.2(1)-245.5(shows)-249.1(the)-244.1(percent)-10.5(age)-242.1(of)-247.8(infants)-246.6(who)]TJ
0 -1.0527 TD
[(wer)-8.2(e)-405.2(cough-f)-8.9(ree)-403(at)-408.3(each)-408.3(home)-404.9(v)-6.5(isit,)-404.4(for)-409.5(the)-403.4(tota)-8.2(l)-401.5(study)]TJ
0 -1.0471 TD
[(perio)-8.2(d.)-251.5(There)-255(wer)-8.2(e)-251.6(n)0(o)-251.9(statistically)-263.5(signifi)-9.6(cant)-256.6(dif)10.8(ference)-10.2(s.)]TJ
/F5 1 Tf
0 -2.851 TD
[(Symp)-7.4(toms)-340.6(and)-332.3(clin)-8.2(ical)-338.3(findings)]TJ
0 -1.747 TD
[(Th)-6.4(r)32.2(ee-mo)-10.1(nth)-283.5(tr)29(eatm)-9.8(ent)-283.9(perio)-7.8(d.)]TJ
/F6 1 Tf
12.5761 0 TD
[(Th)17.1(e)-274.3(d)0(i)18.9(a)0(r)13.5(y)-273.9(ca)20.4(rd)13.9(s)-275.1(w)0(e)16.9(r)0(e)-265.3(e)0(x)15.1(a)0(-)]TJ
-12.5761 -1.0528 TD
[(mi)15.7(ne)15.1(d)-228.4(f)0(o)13.9(r)-230(sy)20(mp)18.1(to)13.2(m)-231.5(s)0(c)19.6(o)0(r)19.6(e)0(s)13.9(,)-228(th)18.8(e)-234.5(p)0(r)19.6(e)0(s)19.6(c)0(r)13.5(i)0(p)18.8(t)0(i)16.5(o)0(n)-217.8(o)0(f)-225.1(m)0(e)17.7(d)0(i)18.9(c)0(a)14.7(t)0(i)16.5(o)0(n)21.2(s)]TJ
0 -1.0471 TD
(\()Tj
/F10 1 Tf
0.3187 0 TD
(b)Tj
/F6 1 Tf
7.472 0 0 6.641 317.877 494.022 Tm
(2)Tj
9.963 0 0 9.963 321.505 495.723 Tm
[(-a)13.5(go)21.2(ni)18.8(st)17.7(s,)-400.7(co)15.1(rt)17.3(ic)18.4(os)20(te)12.8(ro)19.6(id)18.8(s)-411.7(a)0(n)20.8(d)-410.5(an)15.1(ti)22.2(bi)13.2(ot)18.8(ic)18.4(s\))-402.7(an)20.8(d)-410.5(r)0(e)19.2(s)0(p)14.3(i)0(r)17.3(a)0(-)]TJ
-1.2235 -1.0528 TD
[(to)13.2(ry)-282("e)12.2(ve)20.8(nt)18.9(s")17.1(,)-296.3(d)0(e)15.1(f)0(i)17.3(n)0(e)20.8(d)-296.7(ar)19.2(bi)18.9(tr)17.3(ar)13.5(il)16.5(y)-291(a)0(s)-287.6(a)0(n)-286.5(i)0(n)13.2(c)0(r)19.2(e)0(a)14.7(s)0(e)-282(i)0(n)-288.4(r)0(e)13.5(s)0(p)20(i)0(r)17.3(a)0(-)]TJ
0 -1.0471 TD
[(to)13.2(ry)-316.1(sy)20(mp)18.1(to)18.9(ms)-318.8(th)18.9(at)-317.3(le)18.5(d)-325.1(c)0(a)20.4(r)0(e)13.5(r)0(s)-317.3(t)13.9(o)-325.1(s)0(e)14(e)0(k)-314.9(m)0(e)17.7(d)0(i)18.9(c)0(a)14.7(l)-321.8(ad)15.1(vi)18.9(ce)20.4(.)]TJ
1.0015 -1.0528 TD
[(Th)17.1(e)-314.2(m)0(e)17.7(d)0(i)18.9(a)0(n)-303.5(\()0(9)19.6(5)0(%)-299.8(c)0(o)15.1(n)0(f)19.6(i)0(d)13.2(e)0(n)20.8(c)0(e)-303.9(i)0(n)18.8(t)0(e)18.4(r)0(v)19.6(a)0(l)12.8(\))-309.7(nu)21.2(mb)12.4(er)-299.4(of)-299(da)15.1(ys)]TJ
-1.0015 -1.0471 TD
[(on)-291.8(w)12.4(h)0(i)13.2(c)0(h)-286.5(s)0(c)19.6(o)0(r)19.6(e)0(s)-287.7(\()0(0)14(,)-296.3(1,)-285.7(2)-296.7(a)0(n)20.8(d)-296.7(3\))-287.7(we)16.9(re)-288.1(en)15.1(te)18.5(re)19.2(d)-296.7(o)0(n)-286.1(t)0(h)13.2(e)-291.4(di)13.2(ar)19.2(y)]TJ
0 -1.0527 TD
[(ca)14.7(rd)19.6(s)-229.6(w)0(e)16.9(r)0(e)-225.5(8)0(4)21.2(.)0(0)-223.1(\()0(8)19.6(2)0(.)15.9(0)0(\261)21.2(8)0(6)15.5(.)0(0)21.6(\))-230(fo)13.9(r)-230(F)11.4(P)-227.6(i)0(n)13.2(f)0(a)19.2(n)0(t)18.9(s)-229.6(an)15.1(d)-228.4(8)0(3)21.2(.)0(5)-223.1(\()0(8)19.6(1)0(.)15.9(7)0(\261)]TJ
0 -1.0471 TD
[(85)15.5(.0)15.9(\))-224.3(f)0(o)19.6(r)-224.3(th)13.2(os)20(e)-223.1(o)0(n)-217.8(p)0(l)18.9(a)0(c)14.7(e)0(b)20.8(o)0(.)-217.4(T)69.1(ab)20.8(le)-220.6(3)-222.7(show)-8.2(s)-235.3(the)-232.7(medi)-9(an)-235.2(\(and)]TJ
0 -1.0527 TD
[(95%)-249.4(confi)-8.2(dence)-249.7(intervals)-11.9(\))-247.1(percentage)-252.6(of)-247.8(days)-249.3(with)-250.7(symp-)]TJ
0 -1.0471 TD
[(tom)-366.3(scores)-367.9(of)-355.9(0,)-359.6(1)-359.3(a)-6.9(nd)-360(2.)-359.6(The)-359.6(medi)-9(ans)-356.7(for)-364(a)-359.7(score)-365.9(of)-361.6(3)]TJ
0 -1.0528 TD
[(wer)-8.2(e)-331.2(zero.)]TJ
1.0015 -1.0527 TD
[(In)-458.4(or)14(de)20.8(r)-469(t)0(o)-459.2(a)0(s)19.6(s)0(e)13.9(s)0(s)-453.5(t)0(h)13.2(e)-467.8(ne)20.8(ed)-457.2(fo)13.9(r)-463.3(a)0(d)15.1(d)0(i)18.9(t)0(i)16.5(o)0(n)15.5(a)0(l)-453.9(p)0(r)14(e)0(s)19.6(c)0(r)13.5(i)13.9(be)15.1(d)]TJ
-1.0015 -1.0471 TD
[(me)12(di)18.9(ca)20.4(ti)16.5(on)15.5(s,)-406.4(in)18.9(fa)19.2(nt)13.2(s)-411.7(w)0(i)14.9(t)0(h)18.9(d)0(r)13.9(a)0(w)16.9(n)-410.5(fr)12.4(om)-403(th)13.2(e)-416.6(s)0(t)17.7(u)0(d)21.2(y)-416.2(we)16.9(re)-407.6(in)18.8(-)]TJ
0 -1.0527 TD
[(cl)12.8(ud)21.2(ed)-349.1(in)-351(th)18.9(e)-359.7(a)0(n)20.8(a)0(l)12.8(y)0(s)20(i)0(s)-352.2(u)0(p)-348.7(t)0(o)-345.3(t)0(h)18.8(e)-359.7(da)15.1(y)-359.3(o)0(f)-344.6(t)0(h)13.2(e)0(i)18.5(r)-355.2(wi)14.9(th)18.9(dr)13.9(aw)16.9(al)18.5(.)]TJ
ET
1 i 
58.28 758.834 228.019 -0.51 re
f
58.28 742.393 228.019 -0.51 re
f
58.28 498.784 228.019 -0.51 re
f
BT
/F3 1 Tf
8.966 0 0 8.966 58.28 772.667 Tm
[(Table)-331.9(1.)-336.7(\261)-333.2(Demographic)-528.8(data)-522.5(of)-526.4(the)-530.8(fluticasone)-527.8(propio-)]TJ
0 -1.0559 TD
[(nate)-332.9(\(FP\))-336.5(and)-329.3(placebo)-334.6(group)]TJ
/F6 1 Tf
13.7966 -1.7072 TD
[(FP)-5282.1(Placebo)]TJ
-13.7966 -2.0044 TD
[(Subjects)-335.1(n)-9660.9(2)0(4)-6404.1(2)0(4)]TJ
0 -1.0559 TD
[(Sex)-667.1(M/F)-9364.4(13/1)31.3(1)-5146.4(14/10)]TJ
T*
[(Gestation)-670.5(weeks)-4048.1(39.4)-330.2(\(36.8\26143.0\))-679.7(39.7)-330.2(\(36.0\26142.0\))]TJ
T*
[(W)70.8(eight)-665.9(centile)-5851.6(43.8)-336.5(\(2\26197\))-2673.5(37.3)-336.5(\(2\26198\))]TJ
T*
[(Length)-666.5(centile)-5510.2(47.5)-330.2(\(0.4\26191\))-1929.8(42.2)-330.2(\(2\26199.6\))]TJ
0 -1.0496 TD
[(Age)-665.5(months)-6489.7(3.8)-330.7(\(0.9\2614.7\))-1926.3(3.9)-330.7(\(1.0\26110.9\))]TJ
0 -1.0559 TD
(Race)Tj
0.3351 -1.0559 TD
[(Caucasian)-9442.9(19)-6404.1(19)]TJ
T*
[(Other)-11764.5(5)-6904.1(5)]TJ
-0.3351 -1.0559 TD
[(Family)-337.1(history)]TJ
0.3351 -1.0559 TD
[(Eczema)-330.2(\(index)-335.2(case\))-5676.9(5)-6904.1(6)]TJ
T*
[(Asthma)-334.3(in)-330.2(mother)-6697.9(4)-6904.1(4)]TJ
T*
[(Eczema)-330.2(in)-336.5(mother)-6653.6(3)-6904.1(7)]TJ
T*
[(Rhinitis)-333.8(in)-336.5(mother)-6641(3)-6904.1(5)]TJ
-0.3351 -1.0559 TD
[(Exposure)-336.4(to)-330.2(smoking)]TJ
0.3351 -1.0559 TD
[(Passive)-10545.9(15)-6404.1(15)]TJ
T*
[(Parental)-334.7(cigarettes)]TJ
/F12 1 Tf
7.3283 0.2213 TD
(.)Tj
/F6 1 Tf
0.2719 -0.2213 TD
(day)Tj
6.725 0 0 5.977 142.299 582.463 Tm
(-1)Tj
8.966 0 0 8.966 165.713 578.494 Tm
[(12.7)-336.5(\(0\26140\))-2926.4(8.5)-330.7(\(0\26140\))]TJ
-11.9819 -1.0559 TD
[(Breast)-334.5(fed)-334.3(\(ever\))-7561.6(8)-6417.3(1)25.8(1)]TJ
T*
[(RSV)-11911.1(10)-6404.1(10)]TJ
T*
[(Other)-332.7(virus)-9789.9(1)-6904.1(3)]TJ
T*
[(Oxygen)-335.1(therapy)-7390.8(10)-6404.1(12)]TJ
T*
(NG/)Tj
/F5 1 Tf
1.7072 0 TD
[(i.v)71.8(.)]TJ
/F6 1 Tf
1.4669 0 TD
[(feed)-9476.5(8)-6417.3(1)25.8(1)]TJ
-3.1741 -1.0559 TD
[(Days)-337.3(into)-331.5(illness)]TJ
0.3351 -1.0559 TD
[(on)-327.8(admission)]TJ
11.7733 1.0559 TD
[(3.7)-330.7(\(1\2617.5\))-2556.2(3.8)-330.7(\(1.5\2617.5\))]TJ
-12.1084 -2.1055 TD
[(Hospital)-336.1(stay)-665.2(days)-4342.8(3.2)-330.7(\(1\2616.5\))-2929.3(3.5)-330.7(\(1\2618.5\))]TJ
0 -1.9475 TD
[(Data)-338.3(are)-334.1(presented)-334.4(as)-335.1(n)-334.6(o)0(r)-335.1(mean)-334.5(\(range\).)-343.2(Respiratory)-335.3(syncytial)]TJ
0 -1.0559 TD
[(virus)-400.3(\(RSV\))-398(and)-390.3(other)-398.9(virus)-400.3(refer)-398.2(to)-393.4(positive)-402.4(results)-396.3(on)-397.3(naso-)]TJ
T*
[(pharyngeal)-263.1(aspirate)-267.7(immunofluorescent)-270.2(test)-269.3(and/or)-265.6(viral)-262.2(culture.)]TJ
T*
[(M:)-337.2(male;)-332.4(F:)-335.1(female;)-338.5(NG:)-329.9(nasogastric.)]TJ
ET
58.28 334.942 478.205 -0.51 re
f
181.247 319.975 181.757 -0.284 re
f
392.315 319.975 78.746 -0.284 re
f
58.28 303.534 478.205 -0.51 re
f
58.28 145.134 478.205 -0.51 re
f
BT
/F3 1 Tf
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[(pl)23.1(et)17(h)]TJ
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[(ma)-18.3(x,)-18.3(FR)-18.4(C)]TJ
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(aw)Tj
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[(\(a)13.5(nd)-428.3(he)15.1(nc)15.1(e)-439.3(o)0(f)]TJ
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(aw)Tj
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[(pl)23.1(et)17(h)]TJ
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[(an)20.8(d)]TJ
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(G)Tj
/F6 1 Tf
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(V)Tj
/F4 1 Tf
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(')Tj
/F6 1 Tf
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[(m)16(a)0(x)19.4(,)15.3(FR)23(C)]TJ
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[([4)13.9(2].)-441.7(The)-6.8(se)-452.7(measurem)-10.7(ents)-456.6(are)-454.3(expres)-8.2(sed)-453.4(as)-452.7(a)-450.7(stand)-7.8(ard)]TJ
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0 -1.0527 TD
[(error)-236.6(score)-235(outside)-233.6(the)-232.7(2\261)-172.2(-2)-230.7(range)-233.8(is)-227(assum)-9.8(ed)-229.6(to)-231.5(represent)]TJ
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[(groups)-371.6(for)-369.7(any)-366.9(of)-361.6(the)-369.3(meas)-8.2(urements)-373.7(shown)-367.4(\(p)]TJ
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[(0.07)-366.9(for)]TJ
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(FRC)Tj
7.97 0 0 7.97 328.138 547.313 Tm
(pleth)Tj
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[(,)-330.4(0.38)-338.4(for)]TJ
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(G)Tj
/F6 1 Tf
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(aw)Tj
9.963 0 0 9.963 404.901 547.313 Tm
[(and)-338.4(0.42)-338.4(for)]TJ
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(V)Tj
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(')Tj
/F6 1 Tf
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(max,FRC)Tj
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(V)Tj
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(')Tj
/F6 1 Tf
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0.0001 Tc
[(ma)19.2(x)16.4(,)0.1(F)19.6(R)0(C)]TJ
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[(we)16.9(re)]TJ
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0 -1.0471 TD
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[(ge)15.1(om)18.1(et)18.4(ri)17.3(c)-200.3(m)0(e)12(a)0(n)-189.7(P)11.4(C)]TJ
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(30)Tj
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[(wa)16.9(s)-201.1(3)0(.)21.6(1)0(0)-189.3(g)]TJ
/F12 1 Tf
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(.)Tj
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0.2675 -0.1992 TD
(dL)Tj
7.472 0 0 6.641 449.575 488.976 Tm
(-1)Tj
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[(0.)15.9(89)-314.5(g)]TJ
/F12 1 Tf
2.538 0.1992 TD
(.)Tj
/F6 1 Tf
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(dL)Tj
7.472 0 0 6.641 348.151 478.545 Tm
(-1)Tj
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/F5 1 Tf
-4.8256 -2.1681 TD
[(Side)-341.6(effects)]TJ
/F6 1 Tf
1.0015 -1.5478 TD
[(No)-580.2(fu)19.6(ng)15.5(al)-579.1(in)18.9(fe)19.2(ct)18.4(io)13.2(ns)-571.8(oc)15.1(cu)15.1(rr)18(ed)-576.7(du)21.2(ri)17.3(ng)-576.3(th)13.2(e)-581.6(t)0(r)17.3(e)0(a)14.7(t)0(m)15.7(e)0(n)20.8(t)]TJ
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0 -1.0471 TD
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0 -1.0527 TD
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0 -1.0471 TD
[(sy)14.4(st)17.7(ol)18.9(ic)-653(bl)18.9(oo)15.5(d)-660.9(p)0(r)19.6(e)0(s)14(s)0(u)20(r)0(e)-652.3(c)0(e)14.7(n)0(t)18.9(i)0(l)16.5(e)0(s)-651.8(m)0(e)17.7(a)0(s)13.9(u)0(r)19.6(e)0(d)-656.3(d)0(u)21.2(r)0(i)17.3(n)0(g)-655.9(t)13.9(he)]TJ
0 -1.0528 TD
[(tr)17.3(ea)14.7(tm)15.7(en)20.8(t)-327.5(p)0(e)20.8(r)0(i)17.3(o)0(d)-320.2(a)0(n)20.8(d)-325.1(6)-325.1(m)0(o)18.1(n)0(t)18.9(h)0(s)-315.7(a)0(f)19.2(t)0(e)12.8(r)-321(th)18.9(e)-325.5(s)0(t)17.7(a)0(r)13.5(t)-321.8(of)-316.1(th)18.9(e)-325.5(t)0(r)17.2(i)0(a)18.5(l)0(.)]TJ
/F5 1 Tf
0 -2.1681 TD
[(Dru)-7.4(g)-330.8(deli)-8.2(very)]TJ
/F6 1 Tf
1.0015 -1.5478 TD
[(Th)17.1(e)]TJ
/F5 1 Tf
1.7527 0 TD
[(in)-220.2(vi)12.8(vo)]TJ
/F6 1 Tf
2.8396 0 TD
[(dr)19.6(ug)-223.5(in)18.9(ha)20.8(la)12.8(ti)22.2(on)-223.5(st)17.7(ud)21.2(y)-228.4(s)0(h)14.3(o)0(w)17.3(e)0(d)-218.2(t)0(h)18.9(a)0(t)-220.6(a)-228.8(me)12(an)-218.2(of)]TJ
-5.5938 -1.0528 TD
[(12)15.5(.1)15.9(5)]TJ
/F10 1 Tf
2.6916 0 TD
(m)Tj
/F6 1 Tf
0.5634 0 TD
-0.0182 Tc
[(g)-497(\()-18.2(95)-18.2(%)-488.7(c)-18.2(on)-18.2(fi)-18.2(de)-18.2(nc)-18.2(e)-487.2(i)-18.2(nt)-18.2(er)-18.2(va)-18.2(l)-489.1(9)-18.2(.6)-18.2(4\261)-18.2(14)-18.2(.7)-18.2(\))-488(F)-6.8(P)-496.2(w)-18.2(as)]TJ
ET
0 0 0 1 K
0 J 0 j 0.5 w 3.864 M []0 d
/GS3 gs
1 i 
92.28 646.131 m
286.413 646.131 l
91.78 643.131 m
91.78 646.131 l
103.78 643.131 m
103.78 646.131 l
115.78 643.131 m
115.78 646.131 l
138.78 643.131 m
138.78 646.131 l
185.78 642.631 m
185.78 646.131 l
233.28 643.131 m
233.28 646.131 l
280.779 643.131 m
280.779 646.131 l
S
BT
/F19 1 Tf
10 0 0 10 90.28 633.131 Tm
0 0 0 1 k
/GS4 gs
0 Tc
[(0)-744(3)-744(6)-1594(12)-3788(24)-3838(36)-3738(48)]TJ
3.25 -1.1 TD
[(Time after hospital discharge  w)10(eeks)]TJ
ET
/GS3 gs
137.28 724.631 m
137.28 725.735 138.175 726.631 139.28 726.631 c
140.385 726.631 141.28 725.735 141.28 724.631 c
141.28 723.526 140.385 722.631 139.28 722.631 c
138.175 722.631 137.28 723.526 137.28 724.631 c
b
278.529 692.131 m
278.529 693.236 279.425 694.131 280.529 694.131 c
281.634 694.131 282.529 693.236 282.529 692.131 c
282.529 691.027 281.634 690.131 280.529 690.131 c
279.425 690.131 278.529 691.027 278.529 692.131 c
b
282.672 699.394 m
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280.529 703.106 l
282.672 699.394 l
b
231.529 748.131 m
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234.634 750.131 235.53 749.235 235.53 748.131 c
235.53 747.026 234.634 746.131 233.529 746.131 c
232.425 746.131 231.529 747.026 231.529 748.131 c
b
235.423 714.894 m
231.136 714.894 l
233.28 718.606 l
235.423 714.894 l
b
184.28 764.131 m
184.28 765.235 185.175 766.131 186.28 766.131 c
187.384 766.131 188.28 765.235 188.28 764.131 c
188.28 763.026 187.384 762.131 186.28 762.131 c
185.175 762.131 184.28 763.026 184.28 764.131 c
b
94.174 671.144 m
89.887 671.144 l
92.03 674.856 l
94.174 671.144 l
b
90.03 681.631 m
90.03 682.736 90.926 683.631 92.03 683.631 c
93.135 683.631 94.03 682.736 94.03 681.631 c
94.03 680.527 93.135 679.631 92.03 679.631 c
90.926 679.631 90.03 680.527 90.03 681.631 c
b
109.923 691.144 m
105.637 691.144 l
107.78 694.856 l
109.923 691.144 l
b
105.78 724.381 m
105.78 725.485 106.676 726.381 107.78 726.381 c
108.885 726.381 109.78 725.485 109.78 724.381 c
109.78 723.276 108.885 722.381 107.78 722.381 c
106.676 722.381 105.78 723.276 105.78 724.381 c
b
117.673 691.144 m
113.387 691.144 l
115.53 694.856 l
117.673 691.144 l
b
113.78 736.881 m
113.78 737.985 114.675 738.881 115.78 738.881 c
116.885 738.881 117.78 737.985 117.78 736.881 c
117.78 735.776 116.885 734.881 115.78 734.881 c
114.675 734.881 113.78 735.776 113.78 736.881 c
b
141.423 710.144 m
137.137 710.144 l
139.28 713.856 l
141.423 710.144 l
b
188.423 722.643 m
184.136 722.643 l
186.28 726.356 l
188.423 722.643 l
b
92.03 681.631 m
102.78 715.131 107.78 724.631 v
112.78 734.131 113.53 735.881 115.53 736.881 c
116.78 737.881 m
121.03 739.881 124.28 737.381 v
127.53 734.881 136.78 725.881 138.78 725.381 c
140.78 724.881 148.03 724.631 y
153.28 726.131 164.03 739.131 v
174.78 752.131 184.03 762.631 186.03 763.631 c
186.53 764.631 m
195.78 770.881 203.78 768.381 v
211.78 765.88 214.03 764.631 217.53 762.131 c
221.03 759.631 232.779 748.631 233.779 747.631 c
234.78 746.631 257.279 721.881 y
277.779 696.131 280.529 692.631 v
92.28 673.131 m
101.28 691.381 107.03 692.881 v
112.78 694.381 108.78 693.381 y
115.78 693.631 l
121.03 694.381 126.28 699.381 v
131.53 704.381 138.28 710.881 y
139.53 712.381 l
148.28 721.631 157.53 723.381 v
166.78 725.131 169.53 725.381 173.78 725.381 c
178.03 725.381 186.53 724.881 y
204.78 722.631 207.53 722.131 v
210.28 721.631 233.029 717.381 y
280.779 701.631 l
S
BT
0 10 -10 0 68.079 647.131 Tm
/GS4 gs
[(Inf)30(ants with no o)15(v)25(er)-25(night cough  %)]TJ
ET
/GS3 gs
91.78 646.131 m
91.78 772.131 l
S
BT
10 0 0 10 75.78 769.414 Tm
/GS4 gs
(80)Tj
ET
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[(fo)19.6(r)-469(m)0(u)12.4(l)0(t)16.5(i)13.9(pl)13.2(e)-467.8(p)0(-)19.6(v)0(a)15.1(l)0(u)18.9(e)0(s)19.6(.)-472.7(D)12.4(u)0(r)14(i)0(n)18.9(g)-467.4(fo)19.6(ll)16.5(ow)17.3(-u)13.9(p,)-456.4(no)-462.5(di)18.9(f)20.4(f)0(e)13.5(r)0(e)19.2(n)0(c)15.1(e)0(s)]TJ
0 -1.0528 TD
[(we)16.9(re)-316.5(ob)15.5(se)19.6(rv)19.6(ed)-314.9(fo)13.9(r)-321(c)0(o)15.1(u)0(g)21.2(h)0(,)-319.8(w)12.4(he)15.1(ez)20.4(e)-325.5(a)0(n)15.1(d)-325.1(w)12.4(e)0(l)12.8(l)0(-)17.3(b)0(e)20.8(i)0(n)18.9(g)0(.)]TJ
1.0015 -1.0471 TD
[(No)-244.5(st)17.7(at)18.5(is)17.7(ti)16.5(ca)20.4(l)-253.5(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nc)20.8(es)-242.1(we)16.9(re)-242.5(fo)13.9(un)21.2(d)-251.2(i)0(n)-242.9(o)0(v)21.2(e)0(r)19.2(n)0(i)13.2(g)0(h)21.2(t)-253.5(re)19.2(co)15.1(r)20.4(-)]TJ
-1.0015 -1.0527 TD
[(de)15.1(d)-347.9(c)0(o)20.8(u)0(g)15.5(h)-347.9(fr)18(eq)20.8(ue)15.1(nc)15.1(y)73.2(.)-347.5(C)11.6(o)0(u)15.5(g)0(h)-337.3(r)0(a)13.5(t)0(e)18.4(s)-349.1(we)16.9(re)-339.3(un)21.2(li)16.5(ke)15.1(ly)-339.7(to)-339.7(ha)20.8(ve)]TJ
0 -1.0471 TD
[(be)15.1(en)-531.2(sp)20(ur)19.6(io)13.2(us)20(ly)-533.1(in)18.9(cr)19.2(ea)14.7(se)19.6(d)-541.4(a)0(s)-532.3(i)0(n)18.9(f)0(a)13.5(n)0(t)-533.1(c)0(o)20.8(u)0(g)15.5(h)-541.4(w)12.4(a)0(s)-532.3(d)0(i)13.2(s)0(t)17.7(i)0(n)18.9(-)]TJ
0 -1.0528 TD
[(gu)15.5(is)17.7(ha)20.8(bl)18.9(e)-445(f)0(r)18(o)0(m)-431.5(p)0(a)15.1(r)0(e)19.2(n)0(t)18.9(a)0(l)-436.8(c)0(o)20.8(u)0(g)15.5(h)-438.9(an)15.1(d)-438.9(o)0(t)18.9(h)0(e)15.1(r)-440.5(en)20.8(vi)13.2(ro)19.6(nm)18.1(en)15.1(ta)18.4(l)]TJ
0 -1.0471 TD
[(no)15.5(is)17.7(es)19.6(.)-302(U)12.4(nd)15.5(er)19.2(re)13.5(co)20.8(rd)13.9(in)18.9(g)-302.4(m)0(a)17.7(y)-296.7(ha)15.1(ve)-292.2(oc)15.1(cu)20.8(rr)18(ed)-292.2(du)15.5(e)-297.1(t)0(o)-294.1(t)0(e)18.4(m)0(p)12.4(o)0(-)]TJ
0 -1.0528 TD
[(ra)19.2(ry)-208(su)20(sp)20(en)15.1(si)17.7(on)-200.7(of)-208(re)19.2(co)15.1(rd)19.6(in)18.9(gs)-201.9(in)-208.8(so)20(me)-204.2(in)18.9(fa)13.5(nt)18.9(s)-212.5(a)0(w)16.9(a)0(k)20.8(e)0(n)15.1(e)0(d)-201.1(b)0(y)]TJ
0 -1.0471 TD
[(ni)18.9(gh)15.5(t-)17.3(ti)16.5(me)-448.9(sy)14.4(mp)18.1(to)18.9(ms)16.9(.)-461.3(U)0(n)17.3(f)0(o)19.6(r)0(t)17.3(u)0(n)15.5(a)0(t)18.4(e)0(l)18.4(y)67.5(,)-455.6(a)0(n)-451.5(a)0(c)14.7(c)0(u)20.8(r)0(a)13.5(t)0(e)-448.2(p)0(o)15.5(w)0(e)16.9(r)]TJ
0 -1.0528 TD
[(ca)14.7(l)13.9(c)0(u)15.1(l)0(a)18.4(t)0(i)16.5(o)0(n)-490.9(w)0(a)11.2(s)-497(no)15.5(t)-503.9(p)0(o)21.2(s)0(s)18.9(i)0(b)13.2(l)0(e)-493.7(b)0(e)20.8(f)0(o)13.9(r)0(e)-492.9(t)0(h)18.9(e)-501.9(tr)17.3(ia)18.4(l.)-492.9(Th)17.1(e)-501.9(d)0(a)15.1(t)0(a)]TJ
T*
[(sh)20(ow)17.3(ed)-508.4(th)13.2(at)-505.1(58)15.5(%)-515.3(o)0(f)-509.6(t)0(h)18.9(e)-513.3(in)13.2(fa)19.2(nt)18.9(s)-519.8(i)13.9(n)-518.6(t)0(h)18.9(e)-519(pl)18.9(ac)14.7(eb)20.8(o)-518.6(g)0(r)19.6(o)0(u)15.5(p)]TJ
0 -1.0471 TD
[(co)15.1(ug)21.2(he)15.1(d)-256.8(a)0(t)-254.7(n)0(i)18.9(g)0(h)15.5(t)-259.2(at)-249(th)18.9(e)-262.9(e)0(n)15.1(d)-256.8(of)-253.5(th)18.9(e)-262.9(3)0(-)19.6(m)0(o)18.1(n)0(t)18.9(h)-262.5(tr)17.3(ia)18.4(l)-259.2(p)0(e)15.1(r)0(i)17.3(o)0(d)21.2(.)-262.1(T)69.1(o)]TJ
0 -1.0528 TD
[(de)15.1(mo)18.1(ns)20(tr)17.3(at)18.4(e)-217.4(a)-211.7(50)21.2(%)-213.7(i)0(m)15.7(p)0(r)13.9(o)0(v)21.2(e)0(m)12(e)0(n)20.8(t)0(,)]TJ
/F5 1 Tf
13.2647 0 TD
[(i.)19.2(e.)]TJ
/F6 1 Tf
1.3942 0 TD
[(on)21.2(ly)-208.8(29)21.2(%)-213.7(c)0(o)15.1(n)0(t)18.9(i)0(n)18.8(u)0(i)18.9(n)0(g)]TJ
-14.6589 -1.0471 TD
[(to)-277.1(co)15.1(ug)21.2(h,)-274.3(wi)14.9(th)-277.1(a)-285.7(p)0(o)15.5(w)0(e)16.9(r)-286.9(of)-276.3(0.)15.9(8)-285.3(w)12.4(ou)15.5(ld)-277.1(ha)15.1(ve)-275.1(re)19.2(qu)15.5(ir)17.3(ed)-275.1(90)-280.4(in)18.9(-)]TJ
0 -1.0527 TD
[(fa)19.2(nt)13.2(s.)-292.6(T)12.2(h)0(e)-292.2(i)0(n)13.2(f)0(r)18(e)0(q)20.8(u)0(e)15.1(n)0(t)-294.1(r)0(e)19.2(c)0(o)15.1(r)0(d)19.6(i)0(n)18.9(g)-302.4(of)-293.3(co)15.1(ug)21.2(h,)-297.1(m)13.2(a)0(d)15.1(e)-302.8(ne)15.1(ce)20.4(ss)18.9(ar)13.5(y)]TJ
0 -1.0471 TD
[(by)-234.8(pr)19.6(ac)14.7(ti)16.5(ca)20.4(l)-247.8(c)0(o)20.8(n)0(s)14.4(i)13.9(de)15.1(ra)19.2(ti)16.5(on)15.5(s,)-235.6(li)22.2(mi)15.7(ts)-238.4(fu)19.6(rt)17.3(he)15.1(r)-241.4(t)0(h)18.9(e)-245.9(in)18.9(te)12.8(rp)19.6(re)19.2(ta)18.4(ti)16.5(on)]TJ
0 -1.0527 TD
[(of)-316.1(th)18.8(e)-325.5(r)0(e)19.2(s)0(u)14.4(l)0(t)16.5(s)-320.6(ob)15.5(ta)18.4(in)18.9(ed)15.1(.)]TJ
1.0015 -1.0471 TD
[(Me)13.2(di)18.9(an)]TJ
/F5 1 Tf
3.2664 0 TD
(S)Tj
/F6 1 Tf
7.97 0 0 7.97 105.676 343.162 Tm
[(a,)25.5(O)]TJ
7.472 0 0 6.641 116.617 341.518 Tm
(2)Tj
9.963 0 0 9.963 123.08 343.162 Tm
[(wa)16.9(s)-280.8(s)0(i)17.7(m)0(i)15.7(l)0(a)18.4(r)-275.5(in)-271.4(th)18.9(e)-274.3(F)0(P)-273.1(a)0(n)20.8(d)-279.6(pl)18.9(ac)20.4(eb)15.1(o)-279.6(g)0(r)19.6(o)0(u)15.5(p)0(s)]TJ
-6.5043 -1.0527 TD
[(du)15.5(ri)17.3(ng)-286.1(th)18.9(e)-302.8(t)0(r)17.3(i)0(a)18.4(l)-299.1(pe)20.8(ri)17.3(od)15.5(,)-296.3(i)0(n)18.9(c)0(l)12.8(u)0(d)21.2(i)0(n)18.9(g)-302.4(t)13.9(h)0(e)-292.2(p)0(r)19.6(o)0(p)15.5(o)0(r)19.6(t)0(i)16.5(o)0(n)-291.7(o)0(f)-287.6(i)0(n)18.9(f)0(a)13.5(n)0(t)18.9(s)]TJ
0 -1.0471 TD
[(wi)14.9(th)-430.7(lo)18.9(w)]TJ
/F5 1 Tf
4.0858 0 TD
(S)Tj
/F6 1 Tf
7.97 0 0 7.97 103.861 322.242 Tm
[(a,)18.4(O)]TJ
7.472 0 0 6.641 114.803 320.598 Tm
(2)Tj
9.963 0 0 9.963 118.431 322.242 Tm
[(.)-444.2(T)12.2(he)15.1(se)-429.9(fi)17.3(nd)15.5(in)18.9(gs)-429.5(ar)13.5(e)-439.3(h)0(a)15.1(r)0(d)19.6(l)0(y)-430.7(s)0(u)14.4(r)0(p)19.6(r)0(i)17.3(s)0(i)17.7(n)0(g)-434(a)0(s)]TJ
/F5 1 Tf
-6.0377 -1.0528 TD
(S)Tj
/F6 1 Tf
7.97 0 0 7.97 63.156 311.754 Tm
[(a,)18.4(O)]TJ
7.472 0 0 6.641 74.098 310.11 Tm
(2)Tj
9.963 0 0 9.963 80.844 311.754 Tm
[(me)17.7(as)19.6(ur)13.9(em)17.7(en)20.8(ts)-295.3(w)12.4(e)0(r)13.5(e)-297.1(ma)17.7(in)13.2(l)13.9(y)-302.4(wi)14.9(th)18.9(in)-288.4(th)18.9(e)-302.8(n)0(o)21.2(r)0(m)16.5(a)0(l)-294.5(r)0(a)19.2(n)0(g)15.5(e)]TJ
-2.2648 -1.0471 TD
[(at)-271.8(th)18.9(e)-280(s)0(t)17.7(a)0(r)19.2(t)-282(of)-270.6(th)18.9(e)-280(t)0(r)17.3(i)0(a)18.4(l)0(,)-271(w)0(i)14.9(t)13.9(h)-279.6(r)0(e)13.5(l)0(a)18.4(t)0(i)16.5(v)0(e)20.8(l)0(y)-271.4(f)0(e)19.2(w)-283.5(in)18.9(fa)19.2(nt)13.2(s)-275.1(i)0(n)-271.4(e)0(i)18.4(t)0(h)13.2(e)0(r)]TJ
0 -1.0527 TD
[(gr)19.6(ou)15.5(p)-222.7(w)0(i)14.9(t)0(h)-214.5(l)0(o)13.2(w)]TJ
/F5 1 Tf
6.1686 0 TD
(S)Tj
/F6 1 Tf
7.97 0 0 7.97 124.611 290.835 Tm
[(a,)25.5(O)]TJ
7.472 0 0 6.641 135.553 289.19 Tm
(2)Tj
9.963 0 0 9.963 139.181 290.835 Tm
[(,)-222.3(d)0(e)15.1(s)0(p)20(i)0(t)16.5(e)-228.8(th)18.9(e)-223.1(p)0(e)15.1(r)0(s)18.4(i)0(s)17.7(t)0(e)18.4(n)0(c)15.1(e)-223.1(of)-219.4(sy)20(mp)18.1(to)13.2(ms)16.9(.)]TJ
-8.1204 -1.0471 TD
[(Th)17.1(er)19.2(e)-297.1(w)0(a)16.9(s)-292.2(th)13.2(us)-281.6(li)16.5(mi)15.7(te)18.4(d)-296.7(s)0(c)19.6(o)0(p)15.5(e)-291.4(fo)13.9(r)-292.6(i)0(m)15.7(p)0(r)19.6(o)0(v)15.5(e)0(m)17.7(e)0(n)15.1(t)-293.4(wi)14.9(th)-282.7(tr)17.3(ea)14.7(t-)]TJ
0 -1.0527 TD
[(me)17.7(nt)18.9(.)-199.6(S)0(i)13.9(m)0(i)15.7(l)13.9(ar)13.5(ly)81.4(,)-199.6(a)0(s)19.6(s)0(e)13.9(s)0(s)18.9(m)0(e)17.7(n)0(t)-191.7(o)0(f)-190.9(l)0(u)18.9(n)0(g)-189.3(f)0(u)19.6(n)0(c)15.1(t)0(i)16.5(o)0(n)-189.3(3)-199.9(mo)18.1(nt)18.9(hs)-190.5(af)13.5(te)18.4(r)]TJ
0 -1.0471 TD
[(co)15.1(mp)18.1(le)18.4(ti)16.5(on)-399.9(of)-401.5(tr)17.3(ea)20.4(tm)15.7(en)15.1(t)-407.2(s)0(h)14.3(o)0(w)17.3(e)0(d)-400.3(n)0(o)-399.9(d)0(i)18.9(f)14.7(fe)19.2(re)19.2(nc)15.1(es)-401.5(be)20.8(tw)14.9(ee)14.7(n)]TJ
25.1977 51.4084 TD
[(th)13.2(e)-274.3(F)0(P)-273.1(a)0(n)20.8(d)-279.6(pl)18.9(ac)14.7(eb)20.8(o)-279.6(g)0(r)19.6(o)0(u)15.5(p)0(s)20(,)-279.2(al)18.4(th)13.2(ou)21.2(gh)-269(so)20(me)-272.5(in)18.9(fa)13.5(nt)18.9(s)-280.8(i)13.9(n)-279.6(e)0(a)14.7(c)0(h)]TJ
0 -1.0471 TD
[(gr)13.9(ou)21.2(p)-245.5(h)0(a)20.8(d)-245.5(lo)18.9(we)16.9(r)-241.4(l)0(u)13.2(n)0(g)-229.2(v)0(o)15.5(l)0(u)18.9(m)0(e)17.7(s)0(,)-235.6(h)0(i)18.9(g)0(h)15.5(e)0(r)]TJ
/F5 1 Tf
15.1539 0 TD
(R)Tj
/F6 1 Tf
7.97 0 0 7.97 466.242 761.216 Tm
(aw)Tj
9.963 0 0 9.963 477.751 761.216 Tm
[(an)15.1(d)-239.8(g)0(r)13.9(e)0(a)20.4(t)0(e)18.4(r)-247.1(ai)18.5(r)20.4(-)]TJ
-16.9066 -1.0528 TD
[(fl)17.3(ow)-233.1(li)16.5(mi)15.7(ta)18.4(ti)16.5(on)-229.2(th)18.9(an)-229.6(no)15.5(rm)16.5(al)-231.9(in)18.9(fa)19.2(nt)13.2(s)-235.3([)0(4)13.9(0].)-236.8(Thi)-8.8(s)-246.7(i)0(s)-249.8(consi)-7.8(stent)]TJ
0 -1.0471 TD
[(wi)-7.8(th)-248.6(the)-255.5(sugges)-7.4(tion)-252.5(that)-252.9(p)-6.5(re-existing)-259.7(abnorm)-9.7(al)-254.7(lung)-250.1(func-)]TJ
0 -1.0528 TD
[(tion)-343.6(infl)-9.4(uences)-342.7(the)-346.5(occurr)-8.6(ence)-340(and)-344.1(severi)-10.6(ty)-339.7(of)-338.9(bronchi)-9.7(o-)]TJ
0 -1.0471 TD
[(litis)-185.2([21].)-183(Inhaled)-180.8(ster)-8.6(oids)-177.3(may)-182.2(be)-178.3(ineffective)-179.7(in)-180.3(such)-181.1(cases.)]TJ
0 -1.0528 TD
[(Unf)-7.8(ortuna)-9(tely)60.1(,)-336.1(bronchial)-338.4(respon)-7.8(siven)-7.8(ess)-335.1(was)-337.9(asses)-8.2(sed)-333.9(in)]TJ
0 -1.0471 TD
[(too)-340.4(few)-338.3(subjects)-338.4(to)-339.7(allow)-337.3(meani)-10.1(ngful)-337.8(compa)-7.8(risons.)]TJ
1.0015 -1.0527 TD
[(Fo)16.3(r)-366.6(e)0(a)14.7(c)0(h)-354.7(s)0(y)20(m)0(p)12.4(t)0(o)18.9(m)-368.1(as)19.6(se)19.6(ss)13.2(ed)20.8(,)-364.6(s)0(c)13.9(o)0(r)19.6(e)0(s)-355.9(o)0(f)-355.9(0)-365(an)15.1(d)-365(1)-365(p)0(r)19.6(e)0(d)15.1(o)0(-)]TJ
-1.0015 -1.0527 TD
[(mi)15.7(na)15.1(te)18.4(d,)-194.6(an)15.1(d)-205.6(t)0(h)18.9(e)-206(pe)20.8(rc)13.5(en)20.8(ta)18.4(ge)-201.1(of)-196.6(da)20.8(ys)-196.2(wi)14.9(th)-197.4(hi)18.9(gh)21.2(er)-197(sc)14(or)19.6(es)-196.6(wa)16.9(s)]TJ
0 -1.0471 TD
[(ge)15.1(ne)15.1(ra)19.2(ll)16.5(y)]TJ
/F10 1 Tf
3.8297 0 TD
(<)Tj
/F6 1 Tf
0.5406 0 TD
[(10)15.5(.)-222.3(F)11.4(ol)18.9(lo)13.2(w)12.4(i)0(n)13.2(g)-222.7(B)11.6(o)0(n)15.5(f)0(e)19.2(r)0(r)12.4(o)0(n)21.2(i)-225.1(co)20.8(rr)12.4(ec)20.4(ti)16.5(on)21.2(s,)-218.6(no)-212.1(st)17.7(at)18.5(is)17.7(-)]TJ
-4.3703 -1.0528 TD
[(ti)16.5(ca)14.7(l)-481.1(d)0(i)13.2(f)20.4(fe)19.2(re)13.5(nc)20.8(es)-475.4(we)16.9(re)-475.8(fo)13.9(un)21.2(d)-484.5(b)0(e)15.1(t)0(w)14.9(e)0(e)20.4(n)-484.5(tr)17.3(ea)14.7(tm)15.7(en)20.8(t)-486.9(g)0(r)19.6(o)0(u)15.5(p)0(s)20(,)]TJ
0 -1.0471 TD
[(co)15.1(nf)19.6(ir)17.3(mi)15.7(ng)-331.6(th)18.9(e)-336.9(r)0(e)19.2(s)0(u)14.4(l)0(t)16.5(s)-337.7(of)-327.5(pr)19.6(ev)15.1(io)18.8(us)-327.1(st)17.7(ud)15.5(ie)18.4(s)-337.7(o)0(f)-327.5(i)0(n)18.9(h)0(a)15.1(l)0(e)18.4(d)-336.5(co)15.1(r)20.4(-)]TJ
0 -1.0527 TD
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2.5165 -1.0749 TD
[(years:)-367.8(changing)-364.6(importance)-368.6(of)-373(bronchiolitis)-367.6(and)-365(passive)]TJ
0 -1.0686 TD
(smoking.)Tj
/F5 1 Tf
4.0087 0 TD
[(Pediatr)-334.4(Pulmonol)]TJ
/F6 1 Tf
7.4927 0 TD
[(1989;)-334.9(6:)-336.5(138\261146.)]TJ
-14.0179 -1.0559 TD
[(10.)-1266.5(Noble)-243.2(V)123.6(,)-249.5(Murray)-245.9(M,)-243.4(W)70.8(ebb)-244.9(MSC,)-251.9(Alexander)-248(J,)-243.9(Swarbrick)]TJ
2.5165 -1.0749 TD
[(AS,)-263(Milner)-275(AD.)-267.7(Respiratory)-272.1(status)-275.8(and)-270.1(aller)9.9(gy)-270.9(nine)-265.7(to)-273.3(10)]TJ
0 -1.0686 TD
[(years)-321.6(after)-330.1(acute)-328(bronchiolitis.)]TJ
/F5 1 Tf
12.5004 0 TD
[(Ar)27.9(ch)-321.2(Dis)-327.8(Child)]TJ
/F6 1 Tf
6.4494 0 TD
[(1997;)-328.6(76:)]TJ
-18.9498 -1.0749 TD
(315\261319.)Tj
-2.5165 -1.0559 TD
[(1)32.1(1)0(.)-1298.6(Pullan)-341.5(CR,)-346.4(Hey)-349.3(EN.)-343.8(Wheezing,)-347.5(asthma,)-346.3(and)-346(pulmonary)]TJ
2.5165 -1.0686 TD
[(dysfunction)-285.6(10)-289.9(years)-290(after)-285.8(infection)-293.9(with)-290.6(respiratory)-293.6(syn-)]TJ
0 -1.0749 TD
[(cytial)-332.4(virus)-337.1(in)-330.2(infancy)57.6(.)]TJ
/F5 1 Tf
9.4211 0 TD
(BMJ)Tj
/F6 1 Tf
2.2004 0 TD
[(1982;)-328.6(284:)-335.5(1665\2611669.)]TJ
-14.138 -1.0559 TD
[(12.)-1266.5(Kattan)-276.4(M,)-275(Keens)-279.7(TG,)-274.2(Lapierrre)-281.7(J,)-275.5(Levison)-275.2(H,)-277.6(Bryan)-274.8(AC,)]TJ
2.5165 -1.0686 TD
[(Reilly)-210.9(BJ.)-216.5(Pulmonary)-214(function)-216.4(abnormalities)-221.2(in)-216.4(symptom-)]TJ
T*
[(free)-568.5(children)-570.3(after)-576.7(bronchiolitis.)]TJ
/F5 1 Tf
14.0748 0 TD
(Pediatrics)Tj
/F6 1 Tf
4.6347 0 TD
[(1977;)-568.9(59:)]TJ
-18.7095 -1.0749 TD
(683\261688.)Tj
-2.5165 -1.0559 TD
[(13.)-1266.5(Rosenber)10.3(g)-309.3(D)0(,)-309.2(T)66.6(sangaris)-311(M,)-312.9(Eigen)-306.6(H,)-309.2(T)60.2(epper)-307.8(R.)-310.6(Outpati-)]TJ
2.5165 -1.0686 TD
[(ent)-342.1(bronchiolitis)-348.6(longitudinal)-347(evaluation.)]TJ
/F5 1 Tf
16.7431 0 TD
[(Am)-347.2(Rev)-343(Respir)]TJ
-16.7431 -1.0749 TD
(Dis)Tj
/F6 1 Tf
1.7072 0 TD
[(1989;)-328.6(139)-333.6(\(Suppl.)-336.9(2\):)-330.6(A317.)]TJ
-4.2237 -1.0559 TD
[(14.)-1266.5(W)77.1(ohl)-392.9(MEB,)-383.3(Stigol)-394.7(LC,)-383.1(Mead)-390.2(J.)-389.3(Resistance)-391.6(of)-392(the)-386.3(total)]TJ
2.5165 -1.0686 TD
[(respiratory)-508.6(system)-509.2(in)-507.2(healthy)-506.6(infants)-509(and)-504.1(infants)-509(with)]TJ
0 -1.0749 TD
(bronchiolitis.)Tj
/F5 1 Tf
5.5768 0 TD
(Pediatrics)Tj
/F6 1 Tf
4.3944 0 TD
[(1969;)-334.9(43:)-336(495\261509.)]TJ
-12.4877 -1.0559 TD
[(15.)-1266.5(Mallory)-331.4(GBJ,)-339.4(Motoyama)-335.5(EK,)-331.1(Koumbourlis)-335.3(AC,)-338.7(Mutich)]TJ
2.5165 -1.0686 TD
[(RL,)-503.3(Nakayama)-506(DK.)-501.7(Bronchial)-504.9(reactivity)-510.6(in)-500.9(infants)-509(in)]TJ
0 -1.0749 TD
[(acute)-353.2(respiratory)-356.9(failure)-363.1(with)-353.8(viral)-357(bronchiolitis.)]TJ
/F5 1 Tf
19.8476 0 TD
(Pediatr)Tj
-19.8476 -1.0686 TD
(Pulmonol)Tj
/F6 1 Tf
4.1921 0 TD
[(1989;)-334.9(6:)-336.5(253\261259.)]TJ
-6.7086 -1.0559 TD
[(16.)-1266.5(Seidenber)9.7(g)-359.9(J)0(,)-357.7(Masters)-369.1(IB,)-361.7(Hudson)-361.8(I,)-357.5(Olinsky)-366.1(A,)-359.8(Phelan)]TJ
2.5165 -1.0749 TD
[(PD.)-294.6(Disturbance)-301.1(in)-298.6(respiratory)-306.3(mechanics)-297.1(in)-298.6(infants)-300.3(with)]TJ
0 -1.0686 TD
(bronchiolitis.)Tj
/F5 1 Tf
5.5768 0 TD
(Thorax)Tj
/F6 1 Tf
3.212 0 TD
[(1989;)-328.6(44:)-336(660\261667.)]TJ
-11.3054 -1.0559 TD
[(17.)-1266.5(Stokes)-523.7(GM,)-524.3(Milner)-527.9(AD,)-520.6(Hodges)-526(IGC,)-528.8(Groggins)-522.2(RC.)]TJ
2.5165 -1.0749 TD
[(Lung)-412.4(function)-412.4(abnormalities)-417.2(after)-418.6(acute)-416.5(bronchiolitis.)]TJ
/F5 1 Tf
22.3768 0 TD
0 Tw
(J)Tj
-22.3768 -1.0686 TD
(Pediatr)Tj
/F6 1 Tf
3.3006 0 TD
[(1981;)-328.6(98:)-336(871\261874.)]TJ
-5.8171 -1.0559 TD
[(18.)-1266.5(Henry)-324(RL,)-319.9(Milner)-325.6(AD,)-324.6(Stokes)-327.7(GM,)-322(Hodges)-323.7(IGC,)-326.5(Grog-)]TJ
2.5165 -1.0686 TD
[(gins)-222.8(RC.)-220(Lung)-222.8(function)-229.1(after)-222.6(acute)-226.8(bronchiolitis.)]TJ
/F5 1 Tf
19.3228 0 TD
[(Ar)27.9(ch)-220.1(Dis)]TJ
-19.3228 -1.0749 TD
(Child)Tj
/F6 1 Tf
2.5355 0 TD
[(1983;)-334.9(58:)-336(60\26163.)]TJ
-5.052 -1.0559 TD
[(19.)-1266.5(Dezateux)-544.5(C,)-538.2(Fletcher)-543.3(ME,)-543.5(Dundas)-545(I,)-540.8(Stock)-542(J.)-541(Infant)]TJ
2.5165 -1.0686 TD
[(respiratory)-255.7(function)-254.3(after)-254.2(RSV)83.4(-proven)-251.1(bronchiolitis.)]TJ
/F5 1 Tf
20.8024 0 TD
[(Am)-258.7(J)]TJ
-20.8024 -1.0749 TD
[(Respir)-333.8(Crit)-331.1(Car)27.2(e)-334.4(Med)]TJ
/F6 1 Tf
9.2251 0 TD
[(1997;)-328.6(155:)-335.5(1349\2611355.)]TJ
-11.7416 -1.0559 TD
[(20.)-1266.5(McConnochie)-298.7(KM,)-303(Mark)-296.6(JD,)-303.6(McBride)-301.9(JT)72.2(,)]TJ
/F5 1 Tf
19.9867 0 TD
[(et)-298.3(al)]TJ
/F6 1 Tf
1.7767 0 TD
[(.)-300.1(Normal)]TJ
-19.2469 -1.0686 TD
[(pulmonary)-341.8(function)-349.2(measurements)-350.2(and)-339.7(airway)-350.9(reactivity)]TJ
0 -1.0749 TD
[(in)-216.4(childhood)-227.6(after)-222.6(mild)-225.9(bronchiolitis.)]TJ
/F5 1 Tf
14.7071 0 TD
[(J)-220.6(Pediatr)]TJ
/F6 1 Tf
3.8507 0 TD
[(1985;)-221.1(107:)]TJ
-18.5577 -1.0686 TD
(54\26158.)Tj
-2.5165 -1.0559 TD
[(21.)-1266.5(Y)98.4(oung)-326.8(S,)-317.1(O)]TJ
/F4 1 Tf
7.303 0 TD
(')Tj
/F6 1 Tf
0.215 0 TD
[(Keeffe)-317.6(PT)74.8(,)-325.4(Arnott)-322.1(J,)-326.1(Landau)-322.4(LI.)-322.5(Lung)-317.6(func-)]TJ
-5.0014 -1.0749 TD
[(tion,)-391.3(airways)-395.8(responsiveness,)-401.5(and)-390.3(respiratory)-401.1(symptoms)]TJ
0 -1.0686 TD
[(before)-352.5(and)-346(after)-355.4(bronchiolitis.)]TJ
/F5 1 Tf
12.3992 0 TD
[(Ar)34.3(ch)-352.9(Dis)-353.1(Child)]TJ
/F6 1 Tf
6.5252 0 TD
[(1995;)-353.9(72:)]TJ
-18.9245 -1.0749 TD
(16\26124.)Tj
-2.5165 -1.0559 TD
[(22.)-1266.5(T)66.6(epper)-371(RS,)-371.9(Rosenberg)-362.2(D,)-372.4(Eigen)-369.8(H.)-372.4(Airway)-373.4(responsive-)]TJ
2.5165 -1.0686 TD
[(ness)-284.7(in)-285.9(infants)-294(following)-285(bronchiolitis.)]TJ
/F5 1 Tf
15.6998 0 TD
[(Pediatr)-290.2(Pulmonol)]TJ
/F6 1 Tf
-15.6998 -1.0749 TD
[(1992;)-328.6(13:)-336(6\26110.)]TJ
-2.5165 -1.0559 TD
[(23.)-1266.5(Caswell)-471.5(SJ,)-475.9(Thompson)-470.4(AH,)-476.4(Ashmore)-471.4(SP)105(,)-477.1(Beardsmore)]TJ
2.5165 -1.0686 TD
[(CS,)-390.9(Simpson)-392.5(H.)-397.7(Latent)-390.4(sensitisation)-400.4(to)-393.4(respiratory)-394.8(syn-)]TJ
0 -1.0749 TD
[(cytial)-351.4(virus)-356.1(during)-354.4(acute)-353.2(bronchiolitis)-361.3(and)-352.3(lung)-348.1(function)]TJ
0 -1.0686 TD
[(after)-330.1(recovery)59.7(.)]TJ
/F5 1 Tf
6.1016 0 TD
[(Ar)34.3(ch)-333.9(Dis)-334.1(Child)]TJ
/F6 1 Tf
6.4747 0 TD
[(1990;)-334.9(65:)-329.7(946\261952.)]TJ
12.9051 73.624 TD
[(24.)-1266.5(Roosevelt)-555.7(G,)-549.5(Sheehan)-550.8(K,)-549.5(Grupp-Phelan)-556(J,)-547.4(T)60.2(anz)-554.4(RR,)]TJ
2.5165 -1.0939 TD
[(Listernick)-424.6(R.)-418.1(Dexamethasone)-418.3(in)-418.7(bronchiolitis:)-426.4(a)-422.9(rando-)]TJ
0 -1.1002 TD
[(mised)-331.5(controlled)-337.7(trial.)]TJ
/F5 1 Tf
9.1935 0 TD
(Lancet)Tj
/F6 1 Tf
3.0287 0 TD
[(1996;)-334.9(348:)-335.5(292\261295.)]TJ
-14.7387 -1.0559 TD
[(25.)-1266.5(Dennis)-243.9(JL.)-234.2(Steroid)-247.1(in)-241.7(the)-240.9(treatment)-238.7(of)-240.2(obstructive)-249.8(bronch-)]TJ
2.5165 -1.0939 TD
[(iolitis:)-251.7(a)-239.6(double-blind)-248.4(study)62.2(.)]TJ
/F5 1 Tf
11.337 0 TD
[(South)-246.4(Med)-245.3(J)]TJ
/F6 1 Tf
5.2038 0 TD
[(1963;)-246.4(56:)-241.1(1436.)]TJ
-19.0573 -1.0559 TD
[(26.)-1266.5(Sussman)-663(S,)-664.9(Grossman)-668.1(M,)-660.7(Magoffin)-658.3(R,)-664.7(Schieble)-668.8(J.)]TJ
2.5165 -1.0939 TD
[(Dexamethasone)-393(\(16)]TJ
/F10 1 Tf
8.4348 0 TD
(a)Tj
/F6 1 Tf
0.6323 0 TD
[(-methy)55(,)-388.6(9)]TJ
/F10 1 Tf
4.268 0 TD
(a)Tj
/F6 1 Tf
0.6386 0 TD
[(-fluoroprenisolone\))-395(in)]TJ
-13.9736 -1.0939 TD
[(obstructive)-635.5(respiratory)-641.4(tract)-635(infections)-636(in)-640(children:)-635.4(a)]TJ
T*
[(controlled)-337.7(study)62.2(.)]TJ
/F5 1 Tf
7.0184 0 TD
(Pediatrics)Tj
/F6 1 Tf
4.3944 0 TD
[(1964;)-334.9(34:)-329.7(851\261855.)]TJ
-13.9294 -1.0559 TD
[(27.)-1266.5(Dabbous)-506.5(IA,)-505.7(Tkachyk)-505.3(JS,)-507.5(Stamm)-507.8(SJ.)-507.5(A)-508.7(double-blind)]TJ
2.5165 -1.0939 TD
[(study)-298.2(on)-302.5(the)-297.8(effects)-298.4(of)-297.1(corticosteroids)-309(in)-298.6(the)-297.8(treatment)-308.2(of)]TJ
T*
(bronchiolitis.)Tj
/F5 1 Tf
5.5831 0 TD
(Pediatrics)Tj
/F6 1 Tf
4.3944 0 TD
[(1966;)-334.9(7:)-330.2(477\261484.)]TJ
-12.4941 -1.0559 TD
[(28.)-1266.5(Leer)-400.3(JA,)-404.7(Green)-399.6(JL,)-404.9(Heimlich)-406.1(EM,)]TJ
/F5 1 Tf
17.1477 0 TD
[(et)-405.8(al)]TJ
/F6 1 Tf
1.8842 0 TD
[(.)-401.3(Corticosteroid)]TJ
-16.5154 -1.0939 TD
[(treatment)-643.3(in)-646.3(bronchiolitis:)-647.7(a)-644.2(controlled,)-644.1(collaborative)]TJ
T*
[(study)-317.2(in)-317.5(297)-314.6(infants)-319.3(and)-320.7(children.)]TJ
/F5 1 Tf
13.942 0 TD
[(Am)-315.6(J)-315.4(Dis)-321.5(Child)]TJ
/F6 1 Tf
6.6074 0 TD
(1969;)Tj
-20.5495 -1.0939 TD
[(1)32.1(17:)-336(495\261503.)]TJ
-2.5165 -1.0559 TD
[(29.)-1266.5(Lin)-307.8(Y)104.7(-Z,)-303.5(Hsieh)-307.6(K-H,)-306.1(Chen)-306(W)83.4(,)-306.4(W)26.5(u)-303(K-W)80.2(.)-306.4(Clinical)-306.9(trial)-308.8(of)]TJ
2.5165 -1.1002 TD
[(corticosteroid)-479.1(and)-466.2(beta-2)-474.1(bronchodilator)-475.7(in)-469.3(acute)-473.4(whe-)]TJ
0 -1.0939 TD
[(ezing)-334.5(infants.)]TJ
/F5 1 Tf
5.7475 0 TD
[(Acta)-332.4(Paediatr)-333.9(Sin)]TJ
/F6 1 Tf
7.5496 0 TD
[(1991;)-334.9(32:)-329.6(333\261340.)]TJ
-15.8136 -1.0559 TD
[(30.)-1266.5(Springer)-264.1(C,)-260(Bar-Y)62.4(ishay)-266.4(E,)-258.8(Uwayyed)-261.8(K,)-258.6(A)66.7(vital)-257.3(A,)-264.9(V)54.1(ilozni)]TJ
2.5165 -1.0939 TD
[(D,)-252.3(Godfrey)-260.7(S.)-253.9(Corticosteroids)-263.4(do)-251.9(not)-253.8(affect)-247.2(the)-259.9(clinical)-257.7(or)]TJ
T*
[(physiological)-294.5(status)-288.4(of)-290.8(infants)-294(with)-296.9(bronchiolitis.)]TJ
/F5 1 Tf
19.8539 0 TD
(Pediatr)Tj
-19.8539 -1.0939 TD
(Pulmonol)Tj
/F6 1 Tf
4.1984 0 TD
[(1990;)-328.6(9:)-336.5(181\261185.)]TJ
-6.7149 -1.0559 TD
[(31.)-1266.5(Maayan)-502.8(C,)-500.3(Itzhaki)-501.2(T)72.9(,)-502.4(Bar-Y)62.4(ishay)-500.3(E,)-499.1(Gross)-503.6(S,)-500.5(T)60.2(a)0(l)-500.7(A)0(,)]TJ
2.5165 -1.0939 TD
[(Godfrey)-229.1(S.)-222.3(The)-229.4(functional)-223.9(response)-232.8(of)-221.3(infants)-230.8(with)-227.3(persis-)]TJ
T*
[(tent)-255.4(wheezing)-253.8(to)-260.6(nebulized)-252.4(beclomethasone)-258.8(dipropionate.)]TJ
/F5 1 Tf
T*
[(Pediatr)-334.4(Pulmonol)]TJ
/F6 1 Tf
7.499 0 TD
[(1986;)-334.9(2:)-330.2(9\26114.)]TJ
-10.0155 -1.0559 TD
[(32.)-1266.5(Carlsen)-384.6(K,)-378.7(Leegaard)-378.8(J,)-376.6(Larsen)-381.5(S,)-380.4(\351rstavik)-385.3(I.)-376.4(Nebulised)]TJ
2.5165 -1.0939 TD
[(beclomethasone)-239.8(dipropionate)-235.5(in)-241.7(recurrent)-240.3(obstructive)-237.2(epi-)]TJ
0 -1.1002 TD
[(sodes)-309.4(after)-311.1(acute)-309(bronchiolitis.)]TJ
/F5 1 Tf
12.5636 0 TD
[(Ar)27.9(ch)-308.6(Dis)-308.8(Child)]TJ
/F6 1 Tf
6.4051 0 TD
[(1988;)-309.7(63:)]TJ
-18.9687 -1.0939 TD
(1428\2611433.)Tj
-2.5165 -1.0559 TD
[(33.)-1266.5(Reijonen)-555(T)72.9(,)-553(Korppi)-553.7(M,)-553.2(Kuikka)-558.8(L,)-549.7(Kyllikki)-558.8(R.)-557.2(Anti-)]TJ
2.5165 -1.0939 TD
[(inflammatory)-404.6(therapy)-410.3(reduces)-402.6(wheezing)-405.6(after)-406(bronchio-)]TJ
T*
(litis.)Tj
/F5 1 Tf
2.0486 0 TD
[(Ar)27.9(ch)-333.9(Pediatr)-334.4(Adolesc)-331.8(Med)]TJ
/F6 1 Tf
11.0904 0 TD
[(1996;)-334.9(150:)-335.5(512\261517.)]TJ
-15.6555 -1.0559 TD
[(34.)-1266.5(Richter)-347.9(H,)-347.1(Seddon)-343.1(P)103.1(.)-344.4(Early)-345.5(nebulized)-347.3(budesonide)-345.8(in)-349.1(the)]TJ
2.5165 -1.0939 TD
[(treatment)-516.9(of)-512.1(bronchiolitis)-519.4(and)-516.7(the)-512.8(prevention)-518.7(of)-512.1(post-)]TJ
T*
[(bronchiolitic)-334.6(wheezing.)]TJ
/F5 1 Tf
9.7689 0 TD
[(J)-334.4(Pediatr)]TJ
/F6 1 Tf
4.0719 0 TD
[(1998;)-334.9(132:)-329.1(849\261853.)]TJ
-16.3574 -1.0559 TD
[(35.)-1266.5(Fox)-452.3(GF)75(,)-451.8(Everard)-450.3(ML,)-455(Marsh)-449(MJ,)-452.7(Milner)-452.1(AD.)-451.1(Rando-)]TJ
2.5165 -1.0939 TD
[(mised)-261.9(controlled)-268.1(trial)-270.9(of)-259.2(budesonide)-263.6(for)-266(the)-266.2(prevention)-265.7(of)]TJ
T*
[(post-bronchiolitis)-470.8(wheezing.)]TJ
/F5 1 Tf
11.9503 0 TD
[(Ar)28(ch)-460.3(Dis)-466.9(Child)]TJ
/F6 1 Tf
6.8667 0 TD
[(1999;)-461.4(80:)]TJ
-18.817 -1.0939 TD
(343\261347.)Tj
-2.5165 -1.0559 TD
[(36.)-1266.5(Court)-290(SDM.)-288.5(The)-286.3(definition)-296(of)-284.5(acute)-290(respiratory)-293.6(illness)-290.3(in)]TJ
2.5165 -1.0939 TD
(children.)Tj
/F5 1 Tf
3.819 0 TD
[(Postgrad)-339.3(Med)-333.8(J)]TJ
/F6 1 Tf
6.8414 0 TD
[(1973;)-334.9(49:)-336(771\261776.)]TJ
-13.1769 -1.0559 TD
[(37.)-1266.5(Archer)-368.4(LNJ,)-363.4(Simpson)-367.2(H.)-366.1(Night)-365.9(cough)-364(counts)-367(and)-365(diary)]TJ
2.5165 -1.0939 TD
[(card)-232.4(scores)-227.5(in)-229(asthma.)]TJ
/F5 1 Tf
8.9027 0 TD
[(Ar)27.9(ch)-226.4(Dis)-233(Child)]TJ
/F6 1 Tf
6.1712 0 TD
[(1985;)-227.5(60:)-228.5(473\261474.)]TJ
-17.5903 -1.0559 TD
[(38.)-1266.5(Stocks)-542.6(J,)-547.4(Marchal)-549.9(F)77.8(,)-546.7(Kraemer)-546.6(R,)-544.6(Gutkowski)-551.7(P)109.4(,)-546.7(Bar-)]TJ
2.5165 -1.1002 TD
[(Y)54.1(ishay)56.1(,)-420.2(E)0(,)-423.2(Godfrey)-425.1(S.)-424.6(Plethysmographic)-430.9(assessment)-426.9(of)]TJ
0 -1.0939 TD
[(functional)-508.4(residual)-514.5(capacity)-505.6(and)-510.4(airway)-509(resistance.)]TJ
/F5 1 Tf
21.7255 0 TD
(In)Tj
/F6 1 Tf
0.822 0 TD
(:)Tj
-22.5475 -1.0939 TD
[(Stocks)-479.4(J,)-484.1(Sly)-480(PD,)-478(T)60.2(epper)-484.8(RS,)-479.4(Mor)12.5(gan)-478.8(W)77.1(,)-477.1(eds.)-482.9(Infant)]TJ
T*
[(Respiratory)-335.3(Function)-334.2(T)60.2(esting.)-334.4(New)-333.6(Y)92(ork,)-331.1(W)26.5(iley)60.7(,)-331.7(1996.)]TJ
-2.5165 -1.0559 TD
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