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[([4)19.6(,)-302(1)0(6)15.5(\261)0(2)21.2(0)0(])13.9(.)-296.3(Th)17.1(e)-302.8(h)0(i)18.9(g)0(h)-291.7(i)0(n)18.9(t)0(e)12.8(n)0(s)20(i)0(t)16.5(y)-296.7(of)-293.3(th)13.2(e)-297.1(e)0(l)18.4(i)0(c)12.8(i)0(t)22.2(e)0(d)-292.2(f)0(l)11.6(u)0(o)21.2(r)0(e)19.2(s)0(c)13.9(e)0(n)20.8(c)0(e)]TJ T* [(al)18.4(lo)18.9(ws)-325.3(fo)13.9(r)-332.4(r)0(a)19.2(p)0(i)18.9(d)-330.8(mi)15.7(cr)13.5(os)20(co)20.8(pi)13.2(c)-331.2(s)0(c)19.6(r)0(e)13.5(e)0(n)20.8(i)0(n)18.9(g)-336.5(at)-323(lo)18.9(w)-329.1(m)0(a)12(g)0(n)21.2(i)0(f)17.3(i)0(c)12.8(a)0(-)]TJ 25.1977 30.0746 TD [(ti)16.5(on)15.5(s.)-212.9(Ho)17.3(we)16.9(ve)15.1(r)43.2(,)-222.3(th)18.9(is)-215.7(si)17.7(mp)18.1(le)-214.9(me)17.7(th)13.2(od)-212.1(is)-210(no)15.5(t)-225.1(r)0(o)19.6(u)0(t)18.9(i)0(n)18.9(e)0(l)12.8(y)-222.7(us)20(ed)-212.5(in)]TJ 0 -1.0471 TD 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[(an)15.1(d)-444.6(s)0(t)12(a)0(i)18.5(n)0(i)18.9(n)0(g)-439.7(w)0(i)20.6(t)0(h)-442.1(t)0(h)18.9(e)-450.7(op)21.2(ti)16.5(ca)14.7(l)-447(b)0(r)19.6(i)0(g)18.9(h)0(t)13.2(e)0(n)20.8(e)0(r)-441.7(\()0(B)20.6(l)0(a)12.8(n)0(k)21.2(o)0(p)15.5(h)0(o)21.2(r)14.7(-P)20.4(-)]TJ 0 -1.0471 TD [(fl)17.3(u)]TJ 0.6715 -0.0228 TD (\310)Tj 0.3983 0.0228 TD [(ss)18.8(ig)18.8(;)-327.5(B)11.6(ay)15.1(er)-316.5(A)12.4(G)0(,)-318.1(L)0(e)16.7(v)0(e)20.8(r)0(k)13.9(u)0(s)20(e)0(n)15.1(,)-324.7(G)12.4(e)0(r)13.5(m)0(a)17.7(n)0(y)15.5(\))0(.)]TJ /F6 1 Tf 8.4846 -3.9322 TD (Methods)Tj /F4 1 Tf -9.5544 -2.0998 TD [(Pr)27.3(otocol)]TJ /F3 1 Tf 1.0015 -2.0998 TD [(Be)16.1(tw)14.9(ee)14.7(n)-365(O)12.4(ct)12.8(ob)21.2(er)-356.3(19)15.5(94)-354.3(an)15.1(d)-365(S)11.4(ep)15.1(te)18.5(mb)18.1(er)-356.3(19)15.5(96)21.2(,)-364.6(a)0(l)12.8(l)-361.6(BA)12.6(L)]TJ -1.0015 -1.0471 TD 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[(me)12(nt)18.9(;)-304.7(3)0(\))-299(p)0(u)21.2(l)0(m)15.7(o)0(n)15.5(a)0(r)19.2(y)-308.1(in)18.8(fi)17.3(lt)16.5(ra)19.2(te)12.8(s)-303.6(w)0(i)14.9(t)0(h)-294.1(i)0(d)13.2(e)0(n)20.8(t)0(i)16.5(f)0(i)17.3(c)0(a)14.7(t)0(i)16.5(o)0(n)-291.7(o)0(f)-287.7(f)0(u)13.9(n)0(g)21.2(i)]TJ T* [(in)-447.8(co)20.8(rr)12.3(es)19.6(po)15.5(nd)21.2(in)18.9(g)-456(c)0(l)18.5(i)0(n)18.9(i)0(c)12.8(a)0(l)-442.5(s)0(p)20(e)0(c)14.7(i)0(m)15.7(e)0(n)20.8(s)-457.2(in)-442.1(im)15.7(mu)18.1(no)15.5(co)15.1(mp)18.1(ro)19.6(-)]TJ 0 -1.0471 TD [(mi)15.7(se)13.9(d)-222.7(h)0(o)15.5(s)0(t)17.7(s)-223.9(wi)14.9(th)-220.2(fe)19.2(ve)15.1(r)-224.3(r)0(e)19.2(s)0(i)17.7(s)0(t)17.7(a)0(n)15.1(t)-225.1(to)-220.2(an)20.8(ti)16.5(bi)18.9(ot)13.2(ic)-214.9(tr)17.3(ea)14.7(tm)15.7(en)20.8(t;)-216.8(an)15.1(d)]TJ 0 -1.0528 TD 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[(Se)15.9(ns)14.4(it)22.2(iv)13.2(it)16.5(y)-177.2(w)0(a)11.2(s)-178.4(de)15.1(fi)17.3(ne)20.8(d)-182.9(a)0(s)-173.8(t)0(r)17.3(u)0(e)-178.3(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)-172.7(r)0(e)13.5(s)0(u)20(l)0(t)16.5(s)-184.1(\(T)21.2(P\))14.7(/\()17.3(TP)17.9(+)]TJ -1.0015 -1.0471 TD [(fa)13.5(ls)17.7(e)-240.2(n)0(e)15.1(g)0(a)20.8(t)0(i)16.5(v)0(e)-229.6(r)0(e)13.5(s)0(u)20(l)0(t)16.5(s)-241(\(F)20.4(N\))15.7(\),)-236(th)18.8(e)-240.2(s)0(p)20(e)0(c)14.7(i)0(f)17.3(i)0(c)18.4(i)0(t)16.5(y)-239.8(as)-230.7(tr)17.3(ue)-235.2(ne)20.8(ga)15.1(ti)16.5(ve)]TJ 0 -1.0528 TD [(re)13.5(su)20(lt)16.5(s)-332(\()0(T)21.2(N)0(\))15.7(/)0(\()17.3(f)0(a)13.5(l)13.9(se)-321.8(po)15.5(si)17.7(ti)16.5(ve)-320.6(re)19.2(su)20(lt)16.5(s)-332(\()0(F)20.4(P)0(\))14.7(+)0(T)16.5(N)0(\))15.7(,)-324.7(th)13.2(e)-325.5(p)0(o)15.5(s)0(i)17.7(t)0(i)16.5(v)0(e)]TJ 0 -1.0471 TD [(pr)13.9(ed)20.8(ic)12.8(t)13.9(i)0(v)13.2(e)-171.9(va)20.8(lu)18.9(e)-171.9(a)0(s)-162.5(T)0(P)17.9(/)0(\()17.3(T)0(P)17.9(+)0(F)15.7(P)11.4(\),)-162.1(an)15.1(d)-171.5(t)0(h)18.8(e)-171.9(ne)20.8(ga)15.1(ti)16.5(ve)-161.3(pr)19.6(ed)15.1(ic)18.5(ti)16.5(ve)]TJ 0 -1.0528 TD [(va)15.1(lu)18.8(e)-240.2(a)0(s)-236.4(T)12.2(N/)14.9(\(T)15.5(N)12.4(+)0(F)15.7(N)0(\))15.7(.)-239.4(Th)17.1(es)13.9(e)-240.2(c)0(a)20.4(l)0(c)18.4(u)0(l)13.2(a)0(t)18.5(i)0(o)18.8(n)0(s)-230.3(w)0(e)16.9(r)0(e)-236.8(p)0(e)20.8(r)0(f)18(o)0(r)13.9(m)0(e)17.7(d)]TJ 0 -1.0471 TD [(fo)13.9(r)-138.9(t)0(h)18.9(e)-137.7(nu)15.5(m)13.2(b)0(e)15.1(r)-138.9(of)-128.3(sp)20(ec)14.7(im)15.7(en)20.8(s,)-133.2(si)17.7(nc)20.8(e)-137.7(s)0(p)14.4(e)0(c)20.4(i)0(m)15.7(e)0(n)15.1(s)-138.5(w)12.4(e)0(r)13.5(e)-137.7(ob)21.2(ta)12.8(i)13.9(n)0(e)15.1(d)]TJ 0 -1.0527 TD 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[(Discuss)-9.1(ion)]TJ /F3 1 Tf -8.1659 -2.0998 TD [(In)-304.7(th)13.2(is)-306.7(st)17.7(ud)21.2(y)67.5(,)-313.4(st)17.7(ai)18.5(ni)18.9(ng)-308.8(wi)20.6(th)-311.2(th)18.9(e)-314.2(o)0(p)15.5(t)0(i)16.5(c)0(a)20.4(l)-316.1(br)19.6(ig)13.2(ht)18.9(en)20.8(er)-310.8(B)11.6(l)0(a)12.8(n)0(-)]TJ -1.0015 -1.0527 TD [(ko)15.5(ph)21.2(or)25.3(-P)20.4(-F)14.7(lu)]TJ 4.8256 -0.0171 TD 0 Tw (\310)Tj 0.3983 0.0171 TD [(ss)18.9(ig)-379.5(pe)20.8(rm)10.8(i)13.9(t)0(t)16.5(e)0(d)-377.5(t)0(h)13.2(e)-382.4(mi)15.7(cr)13.5(os)20(co)15.1(pi)18.9(c)-388.1(d)0(i)18.9(a)0(g)20.8(n)0(o)15.5(s)0(i)17.7(s)-388.9(of)]TJ -5.2239 -1.0471 TD [(IP)100.1(A)-431.5(w)0(i)14.9(t)0(h)18.9(i)0(n)-510.4(m)0(i)15.7(n)0(u)15.5(t)0(e)18.4(s)-514.1(af)13.5(te)18.4(r)-520.2(s)0(p)20(e)0(c)20.4(i)0(m)15.7(e)0(n)-508.4(c)0(o)15.1(l)0(l)16.5(e)0(c)20.4(t)0(i)16.5(o)0(n)15.5(.)-518.2(S)11.4(t)0(a)18.4(i)0(n)18.9(i)0(n)13.2(g)]TJ 0 -1.0528 TD [(se)19.6(ns)14.4(it)16.5(iv)18.9(it)16.5(y)-325.1(w)12.4(as)-316.1(as)-316.1(go)15.5(od)-314.5(as)-316.1(w)12.4(i)0(t)16.5(h)-325.1(cu)15.1(lt)22.2(ur)14(ed)-314.9(sp)20(ec)14.7(im)15.7(en)20.8(s.)]TJ 1.0015 -1.0471 TD [(In)-225.1(t)13.9(h)0(e)-223.9(c)0(u)15.1(r)0(r)18(e)0(n)20.8(t)-230.8(sa)13.9(mp)18.1(le)18.4(s)-229.6(t)0(h)13.2(e)-228.8(di)18.9(ag)15.1(no)21.2(st)17.7(ic)-226.2(yi)18.9(el)18.4(d)-228.4(f)0(r)12.4(o)0(m)-220.9(s)0(t)17.7(a)0(i)18.5(n)0(i)18.9(n)0(g)]TJ -1.0015 -1.0528 TD -0.0194 Tc [(w)-19.4(a)-2.5(s)-488(c)-19.4(om)-19.4(pa)-19.4(r)-5.9(a)-19.4(bl)-19.4(e)-479(t)-19.4(o)-472.9(p)-19.4(r)-5.4(e)-19.4(vi)-19.4(ou)-19.4(s)-477.4(s)-19.4(tu)-19.4(d)-3.9(i)-19.4(es)-482.3(u)-19.4(s)-5(i)-19.4(n)-0.5(g)-486.8(c)-19.4(on)-19.4(v)-3.9(e)-19.4(nt)-19.4(io)-19.4(n)-3.9(a)-19.4(l)]TJ 0 -1.0471 TD 0 Tc [(st)17.7(ai)18.4(ni)18.9(ng)-251.9(or)-247.8(cu)15.1(lt)16.5(ur)19.6(es)19.6(.)-256.5(K)]TJ 6.974 0 0 6.974 144.624 332.22 Tm 0.0001 Tc (AHN)Tj /F4 1 Tf 9.963 0 0 9.963 162.142 332.22 Tm 0 Tc [(et)-249(al)]TJ /F3 1 Tf 1.7072 0 TD [(.)-262.1([)0(7)19.6(])-269.8(reported)-274.2(that)-270(the)-272.5(pres-)]TJ -12.1322 -1.0528 TD [(ence)-385.5(of)]TJ /F4 1 Tf 3.3973 0 TD [(Asper)29.1(gill)-10.2(us)]TJ /F3 1 Tf 4.8654 0 TD [(hyphae)-381(in)-385.2(BAL)-379.2(samp)-7.8(les)-381.8(stained)-387.7(by)]TJ -8.2627 -1.0471 TD [(Giems)-9.2(a)]TJ /F8 1 Tf 3.0274 0 TD (')Tj /F3 1 Tf 0.2162 0 TD [(s,)-286.9(Gra)-8.2(m)]TJ /F8 1 Tf 3.181 0 TD (')Tj /F3 1 Tf 0.2162 0 TD [(s)-286.5(and)-292.9(T)63.4(oluidine-)-10.3(O)-289.2(had)-287.2(a)-285.7(53%)-289.2(sensi)-9(tivity)]TJ -6.6409 -1.0527 TD [(and)-241.7(97%)-243.7(speci)-8.2(ficity)-241.3(for)-244.5(the)-244.1(diagno)-7.4(sis)-240.4(of)-242.1(IP)83(A,)-238.4(an)-7.6(d)-234.1(c)0(u)-7.6(ltures)]TJ 0 -1.0471 TD [(were)-362.2(p)-6.5(ositive)-366.9(in)-356.7(only)-363.9(four)-364.7(of)-361.6(17)-360(cases.)-366.3(In)-361.6(reviewing)-370.8(21)]TJ 0 -1.0528 TD [(immunoc)-8.7(ompr)-7.8(omised)-455.6(pati)-8.2(ents)-450.9(wi)-7.8(th)-447.8(a)-450.7(d)-6.5(iagnosis)-457.5(of)-452.7(IP)83(A)]TJ 0 -1.0471 TD [(inves)-7.8(tigated)-525.4(using)-530.9(BAL)-527.2(and)-520.5(cytol)-9(ogy)60.3(,)-518.2(sensi)-9(tivity)-526.3(was)]TJ 0 -1.0527 TD [(found)-363.9(to)-356.7(be)-360.4(64.0%)-364.3(and)-355.5(speci)-8.2(ficity)-366.5(99.1%,)-364.7(while)-360(cult)-8.2(ure)]TJ 0 -1.0471 TD [(sensiti)-9.6(vity)-349.2(was)-354.9(40.0%)-352.9(and)-355.5(specifici)-12.3(ty)-345.3(90)-7.2(.3%)-351.4([8].)-353(Poorer)]TJ 0 -1.0528 TD [(results)-276.2(were)-271.2(report)-10.6(ed)-269.4(from)-271.2(an)-269.4(outbr)-7.8(eak)-270.6(of)-270.6(aspergillosis)-270.1(in)]TJ T* [(a)-422.3(general)-425.9(inte)-8.2(nsive)-423.2(care)-427(unit)-423.2([27],)-422(or)-424.2(from)-424.8(non-neu)-7.3(tro-)]TJ 0 -1.0471 TD [(penic)-302.9(pati)-8.2(ents)-302.9([28,)-305.9(29].)-300.2(In)-299(the)-306.7(presen)-8.2(t)-299.1(study)-303.3(only)-301.3(tw)-7.8(o)-296.7(F)0(P)]TJ 0 -1.0527 TD [(were)-339.4(encount)-8.5(ered,)-335.9(although)]TJ /F7 1 Tf 11.5063 0 TD (>)Tj /F3 1 Tf 0.552 0 TD [(500)-332.3(speci)-8.2(mens)-337.8(were)-339.4(stain-)]TJ -12.0583 -1.0471 TD [(ed,)-235.6(indicating)-239.9(a)-228.8(high)-238.7(specifici)-12.3(ty)64.4(,)-233.7(not)-232.3(only)-233.1(in)-231.5(a)-234.5(samp)-7.8(le)-231.9(with)]TJ 0 -1.0527 TD [(a)-393.8(relat)-11(ively)-395.9(high)-398.1(preval)-9.4(ence)-396.9(of)-401.5(IP)83(A,)-397.7(but)-397.3(also)-399.7(in)-396.6(a)-393.8(large)]TJ 0 -1.0471 TD [(samp)-7.8(le)-368.5(with)-370.2(a)-371.1(low)-372.8(prevalence.)-378.2(It)-369.7(shoul)-7.4(d)-365(b)0(e)-371.8(noted)-370.8(how-)]TJ 0 -1.0528 TD [(ever)28.7(,)-410.1(that)-406.6(mic)-8.2(roscop)-7.8(y)-404.8(does)-408.7(not)-408.7(allow)-411.3(unequi)-7.4(vocal)-411(con-)]TJ 0 -1.0471 TD [(firmati)-13.5(on)-394.2(of)-390.1(IP)77.3(A)-391.7(because)-400.8(other)-400.8(fungi)-394.7(\()]TJ /F4 1 Tf 15.962 0 TD [(Ps)-6.8(eudallesche)-10.3(ria)]TJ -15.962 -1.0528 TD (boydii)Tj /F3 1 Tf 2.4868 0 TD (,)Tj /F4 1 Tf 0.5122 0 TD [(Fusari)-7.8(um)]TJ /F3 1 Tf 4.137 0 TD [(speci)-8.2(es\))-267.2(may)-273.3(have)-265.6(sim)-9(ilar)-271.6(appearan)-9.3(ces.)]TJ -7.1359 -1.0471 TD [(In)-361.6(the)-363.6(presen)-8.2(t)-361.7(serie)-9.8(s)-360.5(the)-363.6(authors)-369.4(did)-363.2(not)-363.2(encount)-8.5(er)-362(such)]TJ 0 -1.0528 TD [(fungi)-7.8(.)-586.5(However)24.2(,)-586.5(b)0(y)-587.7(microscop)-10.3(ical)-589.1(c)-6.9(riteria)-591.2(only)57.2(,)-586.5(i)0(t)-586.7(i)0(s)]TJ 0 -1.0471 TD [(prudent)-220.3(to)-208.8(descri)-10.6(be)-212.5(all)-212.3(Aspergillus-like)-216.5(fungal)-219.5(elements)-221.3(as)]TJ 25.1977 66.1583 TD [(hya)-8.4(lohyphomyc)-7.9(etes)-513.9(if)-506.3(no)-508(typical)-514.1(conidiopho)-12.8(rs)-505.1(can)-509.6(be)]TJ 0 -1.0471 TD [(detect)-10.6(ed.)]TJ 1.0015 -1.0528 TD [(In)-486.8(th)18.9(e)-496.3(p)0(r)19.6(e)0(s)13.9(e)0(n)20.8(t)-492.5(st)17.7(ud)15.5(y)-490.2(p)0(r)13.9(e)0(v)20.8(i)0(o)13.2(u)0(s)-480.7(c)0(o)15.1(m)0(m)14.9(u)0(n)21.2(i)0(c)18.5(a)0(t)12.8(i)0(o)18.9(n)0(s)-480.7(i)0(n)13.2(f)0(r)18(e)0(-)]TJ -1.0015 -1.0471 TD [(qu)15.5(en)15.1(t)13.9(l)0(y)-339.7(r)0(e)19.2(p)0(o)15.5(r)0(t)17.3(e)0(d)-337.7(p)0(o)21.2(s)0(i)17.7(t)0(i)16.5(v)0(e)-337.7(b)0(l)18.9(o)0(o)15.5(d)-342.2(cu)15.1(lt)22.2(ur)13.9(es)-333.2(fo)13.9(r)-343.8(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-335.2(w)0(i)14.9(t)0(h)]TJ 0 -1.0528 TD [(IP)100.1(A)-533.9([)0(3)19.6(0].)-532.7(The)-541.7(poor)-545.2(sensiti)-9.6(vity)-542.7(of)]TJ /F4 1 Tf 14.8523 0 TD [(Asper)23.4(gillus)]TJ /F3 1 Tf 5.0248 0 TD [(a)-6.9(ntigen)]TJ -19.8771 -1.0471 TD [(test)-9.4(ing)-220.9(in)-225.8(detect)-10.6(ing)-220.9(galact)-10.6(omann)-7.4(an)-223.9(by)-223.5(latex)-225.6(agglut)-9.7(ination,)]TJ 0 -1.0528 TD [(whi)-8.6(ch)-553.9(was)-554.1(enco)-9.6(untered)-556.4(in)-555.9(the)-557.1(presen)-8.2(t)-555.1(study)60.9(,)-552.4(i)0(s)-557.1(well)]TJ 0 -1.0471 TD [(kno)-8(wn)-432.3([1,)-430.3(1)27.7(1)0(,)-433.6(12].)-431.1(It)-432.3(shoul)-7.4(d)-433.3(b)0(e)-428.7(n)-6.5(oted)-432.6(that)-435(the)-431.9(c)-6.9(urrent)]TJ 0 -1.0527 TD [(study)-274.8(was)-275.3(not)-272.1(designed)-277.9(to)-265.7(evalua)-8.2(te)-271.8(serol)-9.4(ogy)60.3(.)-267.8(T)63.4(esting)-278.4(was)]TJ T* [(perfor)-9.8(med)-489.5(only)-494.8(infrequent)-10.7(ly)58.7(,)-484.1(a)0(t)-493.7(the)-488.8(discreti)-11.1(on)-485.2(of)-492.5(each)]TJ 0 -1.0471 TD [(pati)-8.2(ent)]TJ /F8 1 Tf 2.6973 0 TD (')Tj /F3 1 Tf 0.2162 0 TD [(s)-229.6(physi)-7.4(cian,)-234.2(and)-230.3(it)-228.2(is)-232.7(well)-234.1(known)-229.7(that)-235.8(the)-232.7(detection)]TJ -2.9136 -1.0528 TD [(of)-498.2(antigen)-500.3(is)-494.5(imp)-7.8(roved)-495.2(by)-496.6(testing)-503.5(frequently)-500.1(o)-6.5(btained)]TJ 0 -1.0471 TD [(samp)-7.8(les)-598.1([12,)-590.4(31])-595.7(and/or)-600.8(using)-593.5(a)-593(recent)-9.8(ly)-595.7(introduced)]TJ 0 -1.0527 TD [(enz)-8.8(yme)-341.6(link)-7.8(ed)-337.7(immu)-11.7(nosorbent)-348.2(assay)-342.8(\(E)-7.2(LISA\))-8.6(,)-336.1(whi)-8.6(ch)-337.7(is)]TJ 0 -1.0471 TD [(based)-370(on)-360(the)-363.6(same)-366.7(monoc)-7.4(lonal)-367.5(detect)-10.6(or)-361.6(antibo)-9.7(dy)-360(as)-361.6(the)]TJ 0 -1.0527 TD [(agg)-8.4(lutination)-344.3(test)-333.8([32].)]TJ 1.0015 -1.0471 TD [(Mo)13.6(rt)17.3(al)18.4(it)16.5(y)-490.2(f)0(o)19.6(r)-491.7(t)13.9(h)0(e)-479.9(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-483.1(w)0(i)14.9(t)13.9(h)-490.2(I)0(P)100.1(A)-408.7(w)12.4(a)0(s)-481.1(6)0(9)15.5(%)-486.8(in)-481.9(th)18.9(e)]TJ -1.0015 -1.0528 TD [(cu)15.1(rr)18(en)15.1(t)-259.2(s)0(e)14(r)0(i)17.3(e)0(s)-253.5(a)0(n)20.8(d)-262.5(co)20.8(mp)12.4(ar)19.2(ab)15.1(le)-249(to)-254.3(pr)19.6(ev)15.1(io)18.9(us)14.3(ly)-248.6(pu)15.5(bl)18.9(is)17.7(he)15.1(d)-262.5(s)0(e)19.6(r)20.4(-)]TJ 0 -1.0471 TD [(ie)12.8(s)-258([)0(2)13.9(8].)-259.6(Neve)-7.8(rtheless)-277.4(mort)-10.2(ality)-273.1(incre)-8.6(ases)-273.7(wi)-7.8(th)-271.4(the)-272.5(degree)]TJ 0 -1.0527 TD [(of)-338.9(immunos)-9.5(uppres)-7.8(sion)-336.7([28].)]TJ 1.0015 -1.0471 TD [(A)-499.8(l)0(i)16.5(m)0(i)15.7(t)0(a)18.4(t)0(i)16.5(o)0(n)-485.2(o)0(f)-486.8(t)0(h)18.9(e)-496.3(pr)19.6(es)13.9(en)20.8(t)-498.2(s)0(t)17.7(u)0(d)21.2(y)-495.8(is)-488.8(th)18.9(at)-488(au)20.8(to)13.2(ps)20(y)-495.8(o)0(r)]TJ -1.0015 -1.0528 TD [(bi)13.2(op)21.2(sy)-321.4(wa)16.9(s)-326.3(p)0(e)15.1(r)0(f)18(o)0(r)13.9(m)0(e)17.7(d)-325.1(in)-322.6(on)15.5(ly)-316.9(~5)18.1(0%)-322.6(of)-321.8(th)18.9(e)-331.2(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)17.7(.)-324.7(In)-321.8(a)]TJ 0 -1.0471 TD [(st)17.7(ri)17.3(ct)-414(se)19.6(ns)14.4(e)-416.6(t)0(h)18.9(e)-416.6(di)13.2(ag)20.8(no)15.5(si)17.7(s)-417.4(o)0(f)-407.2(I)0(P)100.1(A)-420.1(ne)15.1(ce)20.4(ss)18.8(it)16.5(at)12.8(es)-407.2(ti)16.5(ss)18.9(ue)-411.7(ev)20.8(i-)]TJ 0 -1.0527 TD [(de)15.1(nc)15.1(e)-274.3(o)0(f)-270.6(a)0(n)15.1(g)0(i)18.9(o)0(i)18.9(n)0(v)15.5(a)0(s)19.6(i)0(o)18.9(n)0(.)-268.6(H)0(o)17.3(w)0(e)16.9(v)0(e)15.1(r)43.2(,)-279.2(a)0(n)-269.4(a)0(u)15.1(t)0(o)18.9(p)0(s)20(y)-279.6(re)19.2(qu)15.5(ir)17.3(es)-270.6(th)18.9(e)]TJ 0 -1.0471 TD [(co)15.1(ns)20(en)15.1(t)-282(o)0(f)-276.3(a)-285.7(fa)19.2(mi)15.7(ly)-277.1(me)17.7(mb)18.1(er)-276.7(an)15.1(d)-279.6(a)0(t)-277.5(t)0(h)18.9(e)-285.7(au)15.1(th)18.8(or)19.6(s)]TJ /F8 1 Tf 18.3805 0 TD (')Tj /F3 1 Tf 0.5065 0 TD -0.016 Tc [(in)-16(st)-16(it)-16(ut)-16(io)-16(n)]TJ -18.8869 -1.0528 TD 0 Tc [(as)-384.4(we)16.9(ll)-381.9(as)-384.4(ot)18.9(he)20.8(r)-395(h)0(o)21.2(s)0(p)14.4(i)0(t)22.2(a)0(l)12.8(s)-388.9(th)18.9(is)-380.7(ca)14.7(n)-387.7(b)0(e)-383.2(g)0(a)15.1(i)0(n)18.9(e)0(d)-383.2(o)0(n)21.2(l)0(y)-379.5(i)0(n)13.2(f)0(r)18(e)0(-)]TJ 0 -1.0471 TD [(qu)15.5(en)15.1(t)13.9(l)0(y)75.8(.)-210.9(As)-205.8(di)18.9(sc)19.6(us)14.4(se)19.6(d)-211.3(a)0(b)15.1(o)0(v)21.2(e)]TJ /F4 1 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0.0228 TD [(ss)18.8(ig)]TJ -21.2883 -1.0471 TD [(ha)15.1(s)-360.5(d)0(i)13.2(a)0(g)20.8(n)0(o)15.5(s)0(t)17.7(i)0(c)-351.4(v)0(a)15.1(l)0(u)18.9(e)-359.7(in)-356.7(th)18.9(e)-365.4(d)0(i)18.8(a)0(g)20.8(n)0(o)15.5(s)0(i)17.7(s)-360.5(of)-355.9(in)18.9(va)15.1(si)17.7(ve)-349.1(pu)15.5(lm)15.7(o-)]TJ 0 -1.0527 TD [(na)15.1(ry)-316.1(as)19.6(pe)15.1(r)20.4(g)0(i)18.9(l)0(l)16.5(o)0(s)20(i)0(s)17.7(.)-324.7(T)12.2(h)0(e)-314.9(r)0(e)13.5(l)0(i)22.2(a)0(b)15.1(i)0(l)16.5(i)0(t)16.5(y)73.2(,)-324.7(s)0(i)17.7(m)0(p)18.1(l)0(i)16.5(c)0(i)18.4(t)0(y)-311.2(a)0(n)15.1(d)-319.4(sp)14.3(ee)20.4(d)-325.1(o)0(f)]TJ 0 -1.0471 TD [(th)13.2(e)-319.8(m)0(e)12(t)0(h)18.9(o)0(d)-314.5(r)0(e)19.2(n)0(d)15.5(e)0(r)-316.5(i)0(t)-313.6(s)0(u)14.4(i)13.9(ta)12.8(bl)18.8(e)-325.5(f)0(o)19.6(r)-326.7(di)18.9(ag)20.8(no)15.5(st)17.7(ic)-317.3(ro)19.6(ut)18.9(in)13.2(e.)]TJ /F6 1 Tf 8.966 0 0 8.966 402.349 362.098 Tm [(Refer)11.6(ences)]TJ /F3 1 Tf -10.3759 -2.2762 TD 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[(Eur)-331.9(Respir)-333.8(J)]TJ /F3 1 Tf 5.5073 0 TD [(1998;)-334.9(1)32.1(1)0(:)-330.2(1274\2611280.)]TJ -13.5626 -1.1128 TD [(14.)-1266.5(Caillot)-478.3(D,)-479.9(Casasnovas)-476.7(O,)-479.9(Bernard)-483.2(A,)]TJ /F4 1 Tf 18.798 0 TD [(et)-475.4(al)]TJ /F3 1 Tf 1.9538 0 TD [(.)-477.1(Improved)]TJ -18.2353 -1.1128 TD [(management)-309.9(of)-316.1(invasive)-317.6(pulmonary)-310.2(aspergillosis)-310.5(in)-311.2(neu-)]TJ 0 -1.1065 TD [(tropenic)-279.4(patients)-282(using)-279.2(early)-278.6(thoracic)-279.2(computed)-277.9(tomogra-)]TJ 0 -1.1128 TD [(phic)-322.6(scan)-321.2(and)-327(sur)12(gery)64.5(.)]TJ /F4 1 Tf 9.3389 0 TD [(J)-321.7(Clin)-329.9(Oncol)]TJ /F3 1 Tf 5.5389 0 TD [(1997;)-328.6(15:)-323.3(139\261147.)]TJ -17.3943 -1.1128 TD [(15.)-1266.5(Logan)-278.9(PM,)-279.4(Primack)-284.3(SL,)-275.8(Miller)-283.7(RR,)-283.2(Muller)-281.3(NL.)-280.6(Invasive)]TJ 2.5165 -1.1128 TD [(asper)13.5(gillosis)-273.4(of)-265.5(the)-266.2(airways:)-264.9(radiographic,)-268.4(CT)68.7(,)-262.2(and)-263.8(patho-)]TJ 0 -1.1065 TD [(logic)-330.8(findings.)]TJ /F4 1 Tf 6.1395 0 TD (Radiology)Tj /F3 1 Tf 4.4197 0 TD [(1994;)-328.6(193:)-335.5(383\261388.)]TJ -13.0758 -1.1128 TD [(16.)-1266.5(Hageage)-378.2(GJ,)-379.4(Harrington)-377.7(BJ.)-380.8(Use)-375.8(of)-379.3(calcofluor)-380.3(white)-384.7(in)]TJ 2.5165 -1.1128 TD [(clinical)-333.6(mycology)63.3(.)]TJ /F4 1 Tf 7.7266 0 TD [(Laborat)-333.7(Med)]TJ /F3 1 Tf 5.6337 0 TD [(1984;)-328.6(15:)-336(109\2611)34.2(12.)]TJ -15.8768 -1.1065 TD [(17.)-1266.5(Hollander)-237.9(H,)-239.6(Keilig)-247.4(W)83.4(,)-236.9(Bauer)-242.9(J,)-237.5(Rothemund)-244.4(E.)-239.8(A)-243.1(reliable)]TJ 2.5165 -1.1128 TD [(fluorescent)-349.3(stain)-351(for)-354.5(fungi)-348.6(in)-349.1(tissue)-351.6(sections)-350.4(and)-352.3(clinical)]TJ T* (specimes.)Tj /F4 1 Tf 4.2047 0 TD (Mycopathologia)Tj /F3 1 Tf 6.8414 0 TD [(1984;)-334.9(88:)-329.6(131\261134.)]TJ -13.5626 -1.1128 TD [(18.)-1266.5(Monheit)-349.4(JE,)-348(Cowan)-353(DF)75(,)-350.7(Moore)-346.6(DG.)-349.9(Rapid)-352.1(detection)-356(of)]TJ 2.5165 -1.1065 TD [(fungi)-361.2(in)-361.8(tissues)-371.3(using)-361.4(calcofluor)-367.6(white)-365.7(and)-365(fluorescence)]TJ 0 -1.1128 TD [(microscopy)62.4(.)]TJ /F4 1 Tf 5.1405 0 TD [(Ar)27.9(ch)-333.9(Pathol)-334(Lab)-332.2(Med)]TJ /F3 1 Tf 9.1872 0 TD [(1984;)-334.9(108:)-329.1(616\261618.)]TJ -16.8442 -1.1128 TD [(19.)-1266.5(W)77.1(achsmuth)-462.5(ED.)-463.9(A)-458.1(comparison)-462.4(of)-461.5(the)-462.2(highly)-457(selective)]TJ 2.5165 -1.1128 TD [(fluorescence)-548.3(staining)-547.8(of)-537.4(fungi)-544.6(in)-551.5(tissue)-547.6(sections)-546.4(with)]TJ 0 -1.1065 TD [(Uvitex)-472.7(2B)-477.9(and)-478.8(Calcofluor)-480.1(White)-475.5(M2R.)]TJ /F4 1 Tf 17.0971 0 TD (Histochemical)Tj -17.0971 -1.1128 TD (Journal)Tj /F3 1 Tf 3.4207 0 TD [(1988;)-334.9(20:)-336(215\261221.)]TJ -5.9372 -1.1128 TD [(20.)-1266.5(Aslanzadeh)-405.5(J,)-401.9(Stelmach)-405.1(PS.)-403.7(Detection)-403.5(of)]TJ /F4 1 Tf 19.8856 0 TD (Pneumocystis)Tj -17.369 -1.1065 TD (carinii)Tj /F3 1 Tf 3.0097 0 TD [(with)-385.4(direct)-381.6(fluorescence)-383.9(antibody)-386.2(and)-377.6(calcofluor)]TJ -3.0097 -1.1128 TD [(white)-334.1(stain.)]TJ /F4 1 Tf 4.9761 0 TD (Infection)Tj /F3 1 Tf 3.8443 0 TD [(1996;)-328.6(24:)-336(248\261250.)]TJ 16.6609 48.8887 TD [(21.)-1266.5(Pizzo)-377.3(P)84.1(A)0(.)-372.4(Management)-378.3(of)-366.7(fever)-378.3(in)-374.4(patients)-376.9(with)-379.1(cancer)]TJ 2.5165 -1.1128 TD [(and)-320.7(treatment-induced)-332.3(neutropenia.)]TJ /F4 1 Tf 14.5174 0 TD [(N)-326.7(Engl)-320(J)-328.1(Med)]TJ /F3 1 Tf 6.0321 0 TD (1993;)Tj -20.5495 -1.1128 TD [(328:)-335.5(1323\2611332.)]TJ -2.5165 -1.1065 TD [(22.)-1266.5(Maschmeyer)-441.3(G,)-442(Link)-440.1(H,)-435.7(Hiddemann)-445.1(W)83.4(,)]TJ /F4 1 Tf 19.816 0 TD [(et)-437.4(al)]TJ /F3 1 Tf 1.9158 0 TD [(.)-439.2(Pulmo-)]TJ -19.2153 -1.1128 TD [(nary)-220(infiltrations)-231.9(in)-222.7(febrile)-224(patients)-225.1(with)-227.3(neutropenia.)-223.6(Risk)]TJ T* [(factors)-368.2(and)-371.3(outcome)-373.3(under)-364.9(empirical)-371.4(antimicrobial)-374.2(ther-)]TJ 0 -1.1065 TD [(apy)-276.5(in)-273.3(a)-277.5(randomized)-277.6(multicenter)-278(study)62.2(.)]TJ /F4 1 Tf 15.801 0 TD (Cancer)Tj /F3 1 Tf 3.2057 0 TD [(1994;)-271.7(73:)]TJ -19.0067 -1.1128 TD (2296\2612304.)Tj -2.5165 -1.1128 TD [(23.)-1266.5(European)-550(Society)-555.7(of)-550(Pneumology)-553.9(T)66.6(ask)-549.5(Group.)-554.7(T)60.2(ech-)]TJ 2.5165 -1.1128 TD [(nical)-583.5(recommendations)-590.1(and)-586.3(guidelines)-584.5(for)-582.1(bronchoal-)]TJ 0 -1.1065 TD [(veolar)-322.3(lavage)-321.1(\(BAL\).)-323.6(Report)-320.9(of)-322.4(the)-323.1(European)-322.4(Society)-321.8(of)]TJ 0 -1.1128 TD [(Pneumology)-446.4(T)60.2(ask)-448.4(Group.)]TJ /F4 1 Tf 11.0272 0 TD [(Eur)-452.1(Respir)-447.6(J)]TJ /F3 1 Tf 5.855 0 TD [(1989;)-448.8(2:)-450.3(561\261)]TJ -16.8822 -1.1128 TD (585.)Tj -2.5165 -1.1128 TD [(24.)-1266.5(W)70.8(ood)-289.3(PJ,)-298.8(Fulcher)-295.1(RG.)-294.4(A)-293.7(basis)-299.2(for)-291.3(specific)-299.4(detection)-299.1(and)]TJ 2.5165 -1.1065 TD [(histochemistry)-550.9(of)-550.1(polysaccharides.)]TJ /F4 1 Tf 14.8525 0 TD [(J)-549.4(Histochem)-545(Cyto-)]TJ -14.8525 -1.1128 TD (chem)Tj /F3 1 Tf 2.428 0 TD [(1983;)-328.6(31:)-336(823\261826.)]TJ -4.9445 -1.1128 TD [(25.)-1266.5(Monod)-364.9(M,)-363.5(Baudraz-Rosselet)-369.6(M,)-363.5(Ramelet)-367.5(AA,)-362.6(Frenk)-363.5(E.)]TJ 2.5165 -1.1128 TD [(Direct)-309(mycological)-312.5(examination)-312.6(in)-304.9(dermatologie:)-314.9(a)-309.1(com-)]TJ 0 -1.1065 TD [(parison)-342.2(of)-341.4(diff)10.4(erent)-341.8(methods.)]TJ /F4 1 Tf 12.0894 0 TD (Dermatologica)Tj /F3 1 Tf 6.3482 0 TD [(1989;)-341.3(179:)]TJ -18.4376 -1.1128 TD (183\261186.)Tj -2.5165 -1.1128 TD [(26.)-1266.5(Merz)-233.1(WG,)-225.7(Roberts)-233.1(GD.)-229.8(Detection)-232.8(and)-232.2(Recovery)-228.5(of)-233.9(Fungi)]TJ 2.5165 -1.1065 TD [(from)-336.9(Clinical)-338.5(Specimens.)]TJ /F4 1 Tf 10.5782 0 TD (In)Tj /F3 1 Tf 0.8283 0 TD [(:)-330.7(Murray)-334.4(PR,)-334(ed.)-336.8(Manual)-334.7(of)]TJ -11.4065 -1.1128 TD [(Clinical)-281.6(Microbiology)60.8(.)-274.8(6th)-279.1(Edn.)-276.8(W)77.1(ashington,)-282.2(D.C.,)-274.9(ASM)]TJ T* [(Press,)-337.2(1995;)-328.6(709\261722.)]TJ -2.5165 -1.1128 TD [(27.)-1266.5(Humphreys)-293.4(H,)-296.6(Johnson)-289.7(EM,)-296.9(W)70.8(arnock)-294.6(DW)86.9(,)-293.8(W)26.5(illatts)-293.9(SM,)]TJ 2.5165 -1.1065 TD [(W)32.8(inter)-306.5(RJ,)-305(Speller)-310.1(DC.)-307.1(An)-305.8(outbreak)-302.3(of)-309.8(asper)13.5(gillosis)-311.3(in)-304.9(a)]TJ 0 -1.1128 TD [(general)-334.2(ITU.)]TJ /F4 1 Tf 5.4693 0 TD [(J)-328.1(Hosp)-337.6(Infect)]TJ /F3 1 Tf 5.7791 0 TD [(1991;)-328.6(18:)-336(167\261177.)]TJ -13.765 -1.1128 TD [(28.)-1266.5(Y)104.7(u)-429.5(VL,)-426(Muder)-435.2(RR,)-428.6(Poorsattar)-430.9(A.)-429.3(Significance)-429.6(of)-429.9(isol-)]TJ 2.5165 -1.1128 TD [(ation)-444.6(of)-442.6(Asperg)10.5(illus)-442.1(from)-444.4(the)-443.2(respiratory)-445.4(tract)-445.3(in)-444(diag-)]TJ 0 -1.1065 TD [(nosis)-394.2(of)-385.7(invasive)-393.4(pulmonary)-398.7(asper)13.5(gillosis.)-396.4(Results)-393.8(from)]TJ 0 -1.1128 TD [(a)-271.2(three-year)-271.1(prospective)-272.5(study)62.2(.)]TJ /F4 1 Tf 12.4119 0 TD [(Am)-271.4(J)-264.8(Med)]TJ /F3 1 Tf 4.3249 0 TD [(1986;)-271.7(81:)-272.7(249\261)]TJ -16.7367 -1.1128 TD (254.)Tj -2.5165 -1.1065 TD [(29.)-1266.5(Horvath)-293.7(JA,)-297.2(Dummer)-295.6(S.)-291.8(The)-292.6(use)-296.6(of)-290.8(respiratory-tract)-303.1(cul-)]TJ 2.5165 -1.1128 TD [(tures)-229.4(in)-222.7(the)-228.3(diagnosis)-223.6(of)-227.6(invasive)-229.1(pulmonary)-221.7(aspergillosis.)]TJ /F4 1 Tf T* [(Am)-334.6(J)-334.4(Med)]TJ /F3 1 Tf 4.5209 0 TD [(1996;)-328.6(100:)-335.5(171\261178.)]TJ -7.0374 -1.1128 TD [(30.)-1266.5(Sharma)-560.7(OP)106.6(,)-559.3(Chwogule)-562.5(R.)-557.2(Many)-561.2(faces)-555.4(of)-562.7(pulmonary)]TJ 2.5165 -1.1065 TD [(aspergil)10.3(losis.)]TJ /F4 1 Tf 5.5073 0 TD [(Eur)-331.9(Respir)-340.1(J)]TJ /F3 1 Tf 5.5073 0 TD [(1998;)-334.9(12:)-336(705\261715.)]TJ -13.531 -1.1128 TD [(31.)-1266.5(Edwards)-593.2(JE)-585.4(Jr)49.4(.,)-587.5(Masur)-588.1(H,)-593.7(Rosen)-584.8(PP)98.7(,)-584.6(Armstrong)-594.1(D.)]TJ 2.5165 -1.1128 TD [(Pulmonary)-315.1(disease)-316.7(caused)-319.9(by)-315.1(Candida)-319.2(species.)]TJ /F4 1 Tf 19.209 0 TD [(N)-320.4(Engl)-313.7(J)]TJ -19.209 -1.1128 TD (Med)Tj /F3 1 Tf 2.0929 0 TD [(1991;)-334.9(324:)-329.1(1060\2611062.)]TJ -4.6094 -1.1065 TD [(32.)-1266.5(Herrmann)-445.2(J,)-439.9(Grugel)-446(A,)-442(Freidank)-440(H,)-442(Bertz)-441.3(H,)-442(Finke)-447.1(J.)]TJ 2.5165 -1.1128 TD [(Asperg)10.5(illus-Antigen-Nachweis:)-701.1(V)104.7(ergl)11.6(eich)-689.1(eines)-689.8(neuen)]TJ T* [(Sandwitch-ELISA)-363.4(mit)-365.5(dem)-366.9(Latex-Agglutinationstest)-370.1(bei)]TJ 0 -1.1065 TD 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