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BT
/F1 1 Tf
14.944 0 0 14.944 58.28 712.403 Tm
0.0208 Tc
[(Defaulting)-298.4(from)-296.8(tuberculosis)-296(treatment)-294.9(in)-294.7(the)-296(N)-1(etherlands:)-294.9(rates,)]TJ
4.5448 -1.0357 TD
[(risk)-334(factors)-330.2(a)-0.1(nd)-332.7(trend)-336.5(i)2(n)-332.7(t)-2.9(he)-334(period)-332.7(1993\2611997)]TJ
/F2 1 Tf
10.959 0 0 10.959 88.214 659.565 Tm
0 Tc
[(M.W.)-332.6(Borgdorff)]TJ
/F3 1 Tf
6.7717 0 TD
0 Tw
(*)Tj
/F2 1 Tf
0.5018 0 TD
[(,)-334.6(J)0(.)-331.2(Veen)]TJ
/F3 1 Tf
4.0454 0 TD
(*)Tj
/F2 1 Tf
0.5018 0 TD
[(,)-329.4(N.A.)-335.4(Kalisvaart)]TJ
/F3 1 Tf
7.2631 0 TD
(*)Tj
/F2 1 Tf
0.4966 0 TD
[(,)-334.6(J.F.)-331.2(Broekmans)]TJ
/F3 1 Tf
7.6563 0 TD
(*)Tj
/F2 1 Tf
0.5018 0 TD
[(,)-329.4(N.J.D.)-335.3(Nagelkerke)]TJ
/F3 1 Tf
8.7478 0 TD
(*)Tj
8.219 0 0 7.305 493.512 664.441 Tm
(,)Tj
10.959 0 0 10.959 495.609 659.565 Tm
(**)Tj
/F4 1 Tf
8.966 0 0 8.966 58.28 622.715 Tm
[(Defaulting)-285.7(fr)29(om)-286.8(tuber)30.8(culosis)-281.6(tr)29(eatment)-288.6(in)-285.9(the)-285.2(Netherlands:)-284.5(rates,)-283.1(risk)-287(factors)-287.9(and)-283(tr)29(end)-282.8(in)]TJ
0 -1.0559 TD
[(the)-323.1(period)-329.1(1993\2611997.)-320.8(M.W)85.7(.)-325.4(Bor)28.5(gdorff,)-321.9(J.)-324.6(V)104.5(een,)-323.4(N.A.)-322.8(Kalisvaart,)-328(J.F)121.3(.)-319.1(B)0(r)27.9(oekmans,)-325.8(N.J.D.)]TJ
T*
(Nagelkerke.)Tj
/F5 1 Tf
5.0899 0 TD
(#)Tj
/F4 1 Tf
1.0053 0 TD
[(ERS)-327.9(Journals)-335.6(Ltd)-334.6(2000.)]TJ
/F6 1 Tf
-6.0953 -1.0559 TD
[(ABSTRACT)66.7(:)-228.1(The)-222.8(aim)-229(of)-227.6(this)-228.7(study)-230.7(was)-224.3(to)-227.6(assess)-229.1(the)-225.4(rate)-232.4(of)-227.6(defaulting)-231.1(fr)12.9(om)-227.1(treatment)]TJ
T*
[(among)-350.6(tuber)11.2(culosis)-356(patients)-352.4(diagnosed)-354.9(in)-347.7(the)-351.9(Netherlands)-357.7(in)-347.7(the)-351.9(period)-356.5(1993\2611997,)]TJ
T*
[(whether)-288(risk)-284.4(groups)-273.3(for)-290.1(defaulting)-288(can)-281.4(be)-288.2(identified)-290.1(at)-284.5(the)-282.3(start)-291.2(of)-284.5(tr)12.9(eatment)-287.8(and)-286.5(the)]TJ
T*
[(trend)-323.9(of)-335.1(defaulting)-332.2(over)-339(time.)]TJ
0.999 -1.0559 TD
[(The)-317.7(Netherlands)-313.4(T)78(uber)11.6(culosis)-318.1(Register)-319.2(pr)15.3(ovided)-318.7(data)-313.7(on)-313.7(all)-313.1(patients)-320.8(diagnosed)-317(in)]TJ
-0.999 -1.0559 TD
[(the)-491(Netherlands)-496.8(during)-494.4(the)-497.3(period)-489.2(1993\2611997.)-491.5(Defaulting)-501.3(pr)15.3(obabilities)-502.5(wer)11.3(e)-492.5(det-)]TJ
T*
[(ermined)-343.5(using)-346(Kaplan-Meier)-351.3(survival)-341.7(analysis)-343.1(and)-343.4(risk)-347.7(factors)-346.9(wer)11.3(e)-347(identified)-347(with)]TJ
T*
(Cox)Tj
/F7 1 Tf
1.7198 0 TD
(')Tj
/F6 1 Tf
0.215 0 TD
[(s)-335.8(propor)12.7(tional)-336.4(hazard)-335.1(analysis.)]TJ
-0.9358 -1.0496 TD
[(Of)-261.1(7,529)-260.1(patients)-263.9(with)-262.4(report)10.5(ed)-262.9(treatmen)10.1(t)-266(outcome,)-258.1(718)-264(\(10%\))-258.1(defaulted)-266.9(or)-258(left)-261.3(the)]TJ
-0.999 -1.0559 TD
[(country)-297.6(within)-300.3(1)-296.7(y)0(r)-295.9(after)-302.4(starting)-297(treatment.)-290.4(Defaulting)-305.3(probab)13.9(ilities)-305.1(wer)11.3(e)-296.5(9)0(%)-295.7(\(95%)]TJ
T*
[(confidence)-265(interval)-271.7(\(CI\))-263.6(8\26110%\))-263(among)-268.4(5,256)-260.1(patients)-270.2(in)-259.2(low-risk)-270.1(groups,)-250.9(17%)-263.6(\(95%)]TJ
T*
[(CI)-389.2(14\26119%\))-382.6(among)-382.2(1,437)-386.6(asylum)-385.3(seekers)-388.5(and)-387.7(29%)-383.7(\(95%)-384.1(CI)-389.2(24\26134%\))-382.6(among)-382.2(836)]TJ
T*
[(patients)-358.8(in)-354(other)-350.6(high-risk)-358.3(groups)-342.8(\(other)-357.4(recent)-349.7(immigrants,)-358.1(illegal)-353.5(immigrants,)-358.1(the)]TJ
T*
[(homeless,)-463.7(prisoners)-464.6(and)-463.5(nationals)-467.4(from)-454.4(Eastern)-463(Europe\).)-457(Defaulting)-469.7(pr)15.3(obabilities)]TJ
T*
[(decre)11.2(ased)-339(over)-332.6(time)-336.7(fr)12.9(om)-334.6(12%)-333.1(in)-335.1(1993)-333.1(to)-328.8(7%)-333.6(in)-335.1(1997.)]TJ
0.999 -1.0559 TD
[(Risk)-553.5(groups)-538.8(for)-555.6(defaulting)-553.5(can)-546.9(be)-553.8(recogn)11.5(ized)-554.9(at)-550(the)-554.2(start)-550.4(of)-556.4(tr)12.9(eatment.)-556.3(The)]TJ
-0.999 -1.0559 TD
[(decre)11.2(asing)-239.9(defaulting)-243.7(probab)13.9(ilities)-248.2(wer)11.3(e)-239.6(probab)13.9(ly)-241.7(due)-235.7(in)-240.2(part)-237.6(to)-240.2(shortening)-241.3(treatment)]TJ
T*
[(from)-315.3(9)-322(t)0(o)-322.4(6)-322(months)-319.2(and)-324.4(improved)-311.6(follow-up)-325(of)-322.4(asylum)-322(seekers.)-328.2(However)81.3(,)-319.1(additional)]TJ
T*
[(measure)10.3(s)-380.1(are)-371.1(needed)-384(to)-379.3(r)13.4(educe)-386(defaulting)-382.8(among)-375.9(the)-383.5(homeless,)-381.5(recen)11.2(t)-386.2(immigrants,)]TJ
T*
[(illegal)-334.5(immigrants)-336.2(and)-337.1(prisoners.)]TJ
/F4 1 Tf
T*
[(Eur)-331.9(Respir)-333.8(J)-334.4(2000;)-333.5(16:)-334.6(209\261213.)]TJ
/F3 1 Tf
7.97 0 0 7.97 401.499 623.735 Tm
[(*Royal)-448.7(Netherlands)-444.8(T)27.8(uberculosis)-444.5(Assoc-)]TJ
0 -1.067 TD
[(iation,)-504.6(The)-514.6(Hague)-502.1(and)-512(**Erasmu)13.5(s)-511.3(Uni-)]TJ
0 -1.0599 TD
[(versity)66.5(,)-276.4(Dept)-272.9(of)-280.5(Public)-266.4(Health,)-276.1(Rotterdam)11(,)]TJ
0 -1.067 TD
[(the)-329.4(Netherlands)10.4(.)]TJ
0 -2.1197 TD
[(Corresponde)11.8(nce:)-333.4(M.W)94.6(.)-333.3(Borgdo)14.8(rff)]TJ
0 -1.067 TD
[(Royal)-614.4(Netherlands)-615.5(T)35(uberculosis)-615.2(Assoc-)]TJ
0 -1.0599 TD
(iation)Tj
T*
[(P)103.9(.O.)-325.5(Box)-332.7(146)]TJ
0 -1.067 TD
[(2501)-325.9(CC)-332.4(The)-329.7(Hague)]TJ
0 -1.0599 TD
[(The)-329.7(Netherlands)]TJ
0 -1.067 TD
[(Fax:)-325.1(31)-330.1(703584004)]TJ
0 -2.1197 TD
[(Keywords)11.5(:)-334.6(Defaulting)]TJ
0 -1.067 TD
[(risk)-329.7(factors)]TJ
0 -1.0599 TD
[(treatment)-327.1(interruption)]TJ
T*
(tuberculosis)Tj
0 -2.1268 TD
[(Received:)-327.9(Decemb)12.9(er)-336.4(31)-301.7(1999)]TJ
0 -1.067 TD
[(Accepted)-325.4(after)-331.6(revision)-329.8(May)-326.1(5)-332.2(2000)]TJ
9.963 0 0 9.963 68.258 358.413 Tm
[(In)-441.3(th)13.2(e)-450.7(N)12.4(et)12.8(he)20.8(rl)17.3(an)15.1(ds)20(,)-449.9(t)0(h)13.2(e)-450.7(in)18.9(ci)18.4(de)15.1(nc)20.8(e)-450.7(o)0(f)-447(t)0(u)18.9(b)0(e)20.8(r)0(c)13.5(u)0(l)18.9(o)0(s)20(i)0(s)-443.3(h)0(a)15.1(s)]TJ
-1.0015 -1.0755 TD
[(de)15.1(cr)19.2(ea)20.4(se)13.9(d)-279.6(s)0(t)17.7(r)0(o)19.6(n)0(g)15.5(l)0(y)-271.4(d)0(u)21.2(r)0(i)17.3(n)0(g)-274.7(t)0(h)18.9(e)-280(co)15.1(ur)19.6(se)-270.6(of)-270.6(th)13.2(e)-280(t)0(w)20.6(e)0(n)15.1(t)0(i)16.5(e)0(t)18.4(h)-279.6(ce)14.7(n-)]TJ
0 -1.0698 TD
[(tu)18.9(ry)-361.6(am)17.7(on)15.5(g)-365(t)0(h)18.9(e)-371.1(na)20.8(ti)16.5(ve)-360.4(po)21.2(pu)15.5(la)18.4(ti)16.5(on)15.5(,)-364.6(a)0(n)15.1(d)-365(is)-357.9(be)15.1(co)20.8(mi)15.7(ng)-360(co)15.1(n-)]TJ
0 -1.0755 TD
[(ce)14.7(nt)18.9(ra)19.2(te)18.4(d)-217(i)0(n)-208.8(t)0(h)18.9(e)-217.4(el)18.4(de)15.1(rl)17.3(y)-217(a)0(n)20.8(d)-217(in)-208.8(so)20(ci)18.4(al)18.4(ly)-208.8(ma)17.7(r)14.7(g)0(i)18.9(n)0(a)20.8(l)0(i)16.5(z)0(e)14.7(d)-217(gr)19.6(ou)15.5(ps)]TJ
T*
[(su)20(ch)-246.6(as)-242.1(th)18.8(e)-251.6(h)0(o)15.5(m)0(e)17.7(l)0(e)18.4(s)0(s)-242.9(a)0(n)15.1(d)-251.2(al)18.4(co)15.1(ho)21.2(l)-253.5(o)0(r)-242.1(d)0(r)13.9(u)0(g)-240.5(a)0(d)15.1(d)0(i)18.9(c)0(t)18.4(s)-252.3([1)19.6(,)-262.1(2].)-265.3(In)]TJ
T*
[(recent)-345.5(years,)-343.5(the)-340.8(overal)-9.4(l)-338.9(incidence)-349(of)-338.9(tuberculos)-10.3(is)-340.8(in)-339.7(the)]TJ
0 -1.0698 TD
[(Netherl)-10.7(ands)-266.4(has)-260(incre)-8.6(ased)-266.8(due)-258.8(to)-265.7(immig)-9.2(ration)-267.4(from)-265.5(high-)]TJ
0 -1.0755 TD
[(preval)-9.4(ence)-260.3(countries)-265.6([2\2614].)-257.8(Ens)-7.6(uring)-258.2(compl)-9.7(etion)-259.4(of)-259.2(treat-)]TJ
T*
[(ment)-276.4(in)-271.4(these)-281.3(risk)-275.7(groups)-7.4(,)]TJ
/F4 1 Tf
10.5901 0 TD
(i.e.)Tj
/F3 1 Tf
1.4852 0 TD
[(prevention)-282.2(of)-270.6(defaul)-9.4(ting)-275.3(or)]TJ
-12.0753 -1.0755 TD
[(loss)-241.1(to)-242.9(follow)-9.2(-up,)-243.3(is)-238.4(there)-8.6(fore)-240(a)-240.2(maj)-8.2(or)-242.1(task)-240.3(of)-242.1(tuberc)-9.4(ulosis)]TJ
0 -1.0698 TD
[(contr)-8.2(ol.)-271.7(Thi)-8.8(s)-275.1(may)-273.3(requi)-8.2(re)-276.7(speci)-8.2(al)-277.5(measures.)-282.3(For)-276.2(inst)-9(ance,)]TJ
0 -1.0755 TD
[(a)-348.3(high)-358.2(rate)-349.3(o)-6.5(f)-349.5(defaultin)-10.7(g)-347.9(was)-354.9(recogni)-10.1(zed)-350.2(among)-354.5(asylu)-7.8(m)]TJ
T*
[(seeker)-8.6(s)-246.6(i)0(n)-242.9(1)-6.5(994,)-247.4(leading)-249.9(to)-248.6(the)-249.8(appoin)-7.4(tment,)-251.5(in)-248.6(1995,)-248.1(of)-247.8(a)]TJ
T*
[(public)-351.2(he)-7.6(alth)-349.7(nurse)-354.1(to)-345.3(co-ord)-8.2(inat)-8.2(e)-348.3(follow-up)-354.5(of)-350.2(tuber)-8.2(cu-)]TJ
T*
[(losis)-341(patients)-339.6(in)-334(this)-339.1(group.)]TJ
1.0015 -1.0471 TD
[(Si)19.6(nc)15.1(e)-319.8(1)0(9)21.2(9)0(3)15.5(,)-319.1(th)18.9(e)-319.8(t)0(r)17.3(e)0(a)20.4(t)0(m)15.7(e)0(n)15.1(t)-316.1(ou)15.5(tc)18.4(om)18.1(e)-319.8(o)0(f)-310.4(t)0(u)18.9(b)0(e)15.1(r)0(c)19.2(u)0(l)18.9(o)0(s)14.4(i)0(s)-306.7(p)0(a)15.1(t)0(-)]TJ
-1.0015 -1.0755 TD
[(ie)18.4(nt)18.9(s)-428.7(h)0(a)20.8(s)-423.1(be)15.1(en)-417.3(re)19.2(po)15.5(rt)17.3(ed)-411.7(to)-419.3(th)18.9(e)-422.3(N)0(e)16.9(t)0(h)13.2(e)0(r)19.2(l)0(a)18.4(n)0(d)15.5(s)-423.1(T)40.6(u)0(b)15.5(e)0(r)19.2(c)0(u)15.1(l)13.9(os)14.4(is)]TJ
T*
[(Re)16.1(gi)18.9(st)17.7(er)70.5(.)-404.4(T)40.6(ub)21.2(er)13.5(cu)20.8(lo)13.2(si)17.7(s-)18.4(as)19.6(so)14.4(ci)18.4(at)18.4(ed)-394.6(mo)18.1(rt)17.3(al)18.4(it)16.5(y)-404.8(a)0(m)17.7(o)0(n)21.2(g)-404.8(tu)18.8(be)15.1(r)20.4(-)]TJ
0 -1.0698 TD
[(cu)15.1(lo)18.9(si)17.7(s)-423.1(p)0(a)15.1(t)0(i)22.2(e)0(n)15.1(t)0(s)-414.8(d)0(i)18.9(a)0(g)15.1(n)0(o)15.5(s)0(e)19.6(d)-421.9(in)-419.3(th)18.8(e)-422.3(p)0(e)15.1(r)0(i)17.3(o)0(d)-416.9(1)0(9)21.2(9)0(3)15.5(\261)0(1)21.2(9)0(9)15.5(5)-421.9(ha)15.1(s)]TJ
0 -1.0755 TD
[(be)15.1(en)-212.5(de)20.8(sc)19.6(ri)17.3(be)15.1(d)-222.7(i)0(n)-208.8(a)0(n)-212.5(e)0(a)14.7(r)0(l)17.3(i)0(e)18.4(r)-224.3(pa)20.8(pe)15.1(r)-218.6([)0(5)13.9(])0(.)-230.4(I)0(n)-230.7(the)-232.7(presen)-8.2(t)-230.8(paper)22.2(,)]TJ
T*
[(the)-551.4(risk)-548.8(of)-549.4(defaul)-9.4(ting)-548.4(from)-555.7(treatmen)-11.1(t)-549.4(among)-553.7(patients)]TJ
T*
[(diagno)-7.4(sed)-425(in)-425(the)-426.2(Netherl)-10.7(ands)-425.7(in)-425(the)-426.2(perio)-8.2(d)-421.9(1993\261)-9.5(1997)]TJ
0 -1.0698 TD
[(was)-224.1(esti)-9.4(mated)-226.4(and)-224.6(the)-227(relevant)-229.9(risk)-224.5(facto)-8.6(rs)-220.6(ident)-9(ified.)-227.2(One)]TJ
0 -1.0755 TD
[(object)-10.1(ive)-642.4(of)-640.5(the)-642.4(analysis)-645.7(was)-645.2(to)-641.3(deter)-8.6(mine)-640.6(whet)-9.8(her)]TJ
25.1977 24.6799 TD
[(defaul)-9.4(ting)-303.7(among)-303.3(asylu)-7.8(m)-299.8(seekers)-306.4(has)-299.8(declined)-308(over)-301(time)]TJ
0 -1.0471 TD
[(in)-322.6(response)-323.9(to)-316.9(improved)-326.6(procedu)-7.7(res)-318.5(for)-318.5(the)-318.1(follow)-9.2(-up)-316.9(of)]TJ
0 -1.0527 TD
[(these)-343.9(patients.)]TJ
/F6 1 Tf
9.5544 -2.8794 TD
(Methods)Tj
/F3 1 Tf
-8.5529 -1.8494 TD
[(Th)17.1(e)-217.4(N)0(e)16.9(t)0(h)13.2(e)0(r)19.2(l)0(a)18.4(n)0(d)15.5(s)-212.5(T)34.9(u)0(b)21.2(e)0(r)19.2(c)0(u)15.1(l)0(o)18.8(s)0(i)17.7(s)-218.2(Re)16.1(gi)18.9(st)17.7(er)-208.4(pr)19.6(ov)15.5(id)18.9(ed)-206.8(da)15.1(ta)-209.2(on)]TJ
-1.0015 -1.0528 TD
[(tu)13.2(be)20.8(rc)13.5(ul)18.9(os)20(is)-335.2(pa)20.8(ti)16.5(en)15.1(ts)-329.5(di)13.2(ag)20.8(no)15.5(se)19.6(d)-342.2(i)0(n)-334(t)0(h)18.8(e)-342.6(pe)20.8(ri)17.3(od)-331.6(19)15.5(93)15.5(\2611)21.2(99)15.5(7.)]TJ
0 -1.0471 TD
[(Si)13.9(nc)20.8(e)-359.7(1)0(9)15.5(9)0(3)15.5(,)-358.9(pa)20.8(ti)16.5(en)15.1(t)-356(d)0(a)15.1(t)0(a)-351.4(a)0(t)-351.4(d)0(i)18.9(a)0(g)15.1(n)0(o)21.2(s)0(i)17.7(s)-360.5(ha)15.1(ve)-349.1(be)20.8(en)-354.7(re)19.2(po)15.5(rt)17.3(ed)]TJ
0 -1.0527 TD
[(an)15.1(on)15.5(ym)18.1(ou)21.2(sl)17.7(y)-285.3(t)13.9(o)-285.3(t)0(h)18.9(e)-280(Ne)16.9(th)18.9(er)13.5(la)18.4(nd)21.2(s)-280.8(T)34.9(ub)21.2(er)13.5(cu)20.8(lo)18.8(si)17.7(s)-280.8(R)0(e)16.1(g)0(i)18.9(s)0(t)17.7(e)0(r)-276.7(o)0(n)]TJ
0 -1.0471 TD
[(a)-382.4(p)0(r)19.6(e)0(c)14.7(o)0(d)21.2(e)0(d)-371.8(r)0(e)19.2(p)0(o)15.5(r)0(t)-369.7(f)0(o)13.9(r)0(m)16.5(.)-376(Re)16.1(po)15.5(rt)17.3(in)18.9(g)-376.3(t)0(o)-373.8(t)0(h)18.9(e)-376.7(re)13.5(gi)18.8(st)17.7(er)-367.7(is)-375(vo)21.2(l-)]TJ
0 -1.0528 TD
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T*
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0 -1.0471 TD
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0 -1.0527 TD
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0 -1.0471 TD
[(Kaplan-M)-11.1(eier)-616.7(survi)-9(val)-614(analys)-9(is.)-614.4(Adj)-8.6(ustment)-618(for)-620.1(con-)]TJ
0 -1.0528 TD
[(founder)-8.9(s)-741.7(was)-741.9(carried)-746.2(out)-744.4(using)-741.5(Cox)]TJ
/F7 1 Tf
16.5481 0 TD
(')Tj
/F3 1 Tf
0.2219 0 TD
[(s)-741.7(proportion)-9.9(al)]TJ
-16.77 -1.0471 TD
[(hazards)-276.8(analys)-9(is.)-272.9(V)103.4(ariables)-276.6(for)-272.9(mul)-7.8(tivariate)-281(analysis)-275.8(wer)-8.2(e)]TJ
0 -1.0528 TD
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[(a)-586.9(priori)]TJ
/F3 1 Tf
3.9891 0 TD
[(\(age,)-592(sex)-590(and)-588.8(being)-592.7(asylu)-7.8(m)]TJ
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[(seeker)-8.6(\).)-372.6(Othe)-9.8(r)-372.2(variables)-385.5(were)-373.6(selec)-8.6(ted)-375(if)-375.4(they)-381.4(showed)-380(a)]TJ
0 -1.0527 TD
[(univar)-9(iate)-276.1(associa)-11.3(tion)-275.3(with)-279.2(defaultin)-10.7(g.)-274.3(They)-275(were)-276.8(incl)-8.2(ud-)]TJ
0 -1.0471 TD
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(\(p)Tj
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/F6 1 Tf
8.4846 -2.1112 TD
(Results)Tj
/F3 1 Tf
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-1.0015 -1.0471 TD
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0 -1.0528 TD
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0 -1.0471 TD
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0 -1.0528 TD
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0 -1.0471 TD
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0 -1.0527 TD
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0 -1.0471 TD
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0 -1.0528 TD
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0 -1.0471 TD
[(al)18.4(it)16.5(ie)18.4(s.)]TJ
1.0015 -1.0527 TD
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-1.0015 -1.0471 TD
[(wi)14.9(th)-305.5(re)19.2(po)15.5(rt)17.3(ed)-303.5(tr)17.3(ea)14.7(t)13.9(m)0(e)12(n)0(t)-305.5(o)0(u)21.2(t)0(c)18.4(o)0(m)12.4(e)0(,)-303.2(8)0(3)15.5(9)-313.7(\(1)53.8(1%)13.2(\))-315.3(w)12.4(er)13.5(e)-314.2(t)0(r)17.3(e)0(a)20.4(t)0(e)12.8(d)]TJ
0 -1.0528 TD
[(fo)19.6(r)]TJ
/F8 1 Tf
1.4966 0 TD
(>)Tj
/F3 1 Tf
0.5406 0 TD
[(1)-370.7(y)0(r)70.9(.)-364.6(In)-361.6(th)18.9(e)-365.4(l)0(a)18.4(t)0(t)16.5(e)0(r)-350.7(g)0(r)19.6(o)0(u)15.5(p)0(,)-359.6(9)0(3)21.2(%)-373(re)19.2(po)21.2(rt)17.3(ed)15.1(ly)-356.7(co)15.1(mp)18.1(le)18.4(te)12.8(d)]TJ
-2.0372 -1.0527 TD
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0 -1.0471 TD
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/F8 1 Tf
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-0.5406 -1.0471 TD
[(\(8)19.6(%\))-398.1(de)15.1(fa)19.2(ul)18.9(te)18.4(d,)-393.8(45)15.5(1)-404.8(\()0(7)19.6(%)0(\))-392.4(d)0(i)13.2(e)0(d)-394.6(a)0(n)20.8(d)-404.8(17)21.2(1)-404.8(\()0(3)19.6(%)0(\))-398.1(c)0(o)15.1(n)0(t)18.9(i)0(n)18.9(u)0(e)15.1(d)]TJ
0 -1.0527 TD
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0 -1.0471 TD
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0 -1.0528 TD
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0 -1.0471 TD
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0 -1.0528 TD
[(th)18.9(ro)13.9(ug)21.2(ho)15.5(ut)-294.1(th)18.9(e)-308.5(t)0(r)17.3(e)0(a)20.4(t)0(m)15.7(e)0(n)15.1(t)-304.7(pe)20.8(ri)17.3(od)15.5(\))-304(a)0(t)-294.5(a)-308.5(ra)19.2(te)-300.2(of)-293.3(14)15.5(.8)-291.4(pe)15.1(r)-304(1)0(0)15.5(0)]TJ
0 -1.0471 TD
[(pe)15.1(rs)18.4(on)21.2(-y)13.9(rs)-294.5(\(9)19.6(5%)-299.8(co)15.1(nf)19.6(id)18.9(en)15.1(ce)-292.6(in)13.2(te)18.4(rv)19.6(al)-300.2(\(C)20.6(I\))-300.6(13)21.2(.1)15.9(\2611)21.2(5.)15.9(2\))19.6(.)-307.7(D)0(e)16.9(-)]TJ
0 -1.0528 TD
[(fa)19.2(ul)13.2(ti)22.2(ng)-206.4(pr)19.6(ob)15.5(ab)20.8(il)16.5(it)16.5(ie)18.4(s)-212.5(d)0(e)15.1(c)0(r)19.2(e)0(a)14.7(s)0(e)19.6(d)-211.3(ov)15.5(er)-202.7(th)18.9(e)-211.7(s)0(t)17.7(u)0(d)15.5(y)-211.3(pe)15.1(ri)17.3(od)21.2(,)-210.9(f)0(r)12.4(o)0(m)]TJ
0 -1.0471 TD
0.3169 Tc
[(1)316.9(2)332.4(%i)316.9(n1)316.9(9)332.4(9)316.9(3t)316.9(o)5.7(7)316.9(%i)316.9(n1)316.9(9)332.4(9)316.9(7\()316.9(t)334.2(a)316.9(b)337.7(l)316.9(e1)316.9(\))316.9(.)]TJ
26.1993 66.1583 TD
0 Tc
[(Mo)13.6(st)-221.3(ri)17.3(sk)-224.7(fa)19.2(ct)18.5(or)19.6(s)-235.3(f)0(o)19.6(r)-230(de)15.1(fa)19.2(ul)18.9(ti)16.5(ng)-223.5(we)16.9(re)-219.8(si)17.7(mi)15.7(la)12.8(r)-230(w)0(h)17.3(e)0(n)-218.2(u)0(s)14.4(i)0(n)18.8(g)]TJ
-1.0015 -1.0471 TD
[(th)13.2(e)-416.6(r)0(e)19.2(s)0(t)17.7(r)0(i)17.3(c)0(t)18.4(i)0(v)18.8(e)-416.6(an)15.1(d)-416.2(t)0(h)18.8(e)-416.6(in)18.8(cl)18.5(us)14.3(iv)18.8(e)-416.6(d)0(e)20.8(f)0(i)17.3(n)0(i)13.2(t)0(i)16.5(o)0(n)-405.6(\()0(t)17.3(a)0(b)20.8(l)0(e)-408.3(1\).)-418.9(Fe-)]TJ
0 -1.0528 TD
[(mal)-8.2(es)-282(defaul)-9.4(ted)-283.9(less)-281.4(often)-287(than)-284.7(males.)-290.6(Defaulting)-288.6(did)-283.5(not)]TJ
T*
[(dep)-8.4(end)-315.7(stro)-8.2(ngly)-324.1(on)-314.5(ag)-7.6(e)-314.2(i)0(n)-322.6(univar)-9(iate)-321.6(analys)-9(is,)-318.5(but)-323.3(incre-)]TJ
0 -1.0471 TD
[(ased)-249.8(with)-245.1(age)-242.1(when)-246.4(taki)-8.2(ng)-240.5(into)-246.8(account)-247.9(other)-247.2(risk)-247.2(factors.)]TJ
0 -1.0527 TD
[(Non-)-8.6(Dutch)-249.5(pati)-8.2(ents,)-252.1(in)-242.9(parti)-10.6(cular)-247.6(those)-252.5(from)-254.1(Eastern)-254.4(Eur-)]TJ
0 -1.0471 TD
[(ope)-366.9(and)-366.9(Y)103.4(ugosl)-7.4(avia)-370.4(including)-372.9(former)-371.4(Y)103.4(ugosla)-8.6(vian)-364.3(terri-)]TJ
0 -1.0527 TD
[(tori)-9.4(es,)-475.8(defaul)-9.4(ted)-477.4(relatively)-486.6(often.)-480.9(Default)-10.7(ing)-477(was)-474.4(more)]TJ
0 -1.0471 TD
[(comm)-9.8(on)-246.2(in)-242.9(those)-246.8(who)-250.9(had)-241.7(been)-248.6(in)-248.6(the)-244.1(Netherl)-10.7(ands)-243.7(for)]TJ
/F8 1 Tf
21.7493 0 TD
(<)Tj
/F3 1 Tf
0.552 0 TD
(1)Tj
-22.3013 -1.0527 TD
[(yr)48.1(.)-353.2(Asy)-7.4(lum)-360.6(seekers)-357.7(an)-7.6(d)-353.6(illegal)-362.8(immig)-9.2(rants)-356.5(show)-8.2(ed)-354.7(high)]TJ
0 -1.0471 TD
[(rates)-601.6(of)-594.9(defaultin)-10.7(g,)-593(although)-597.4(asylu)-7.8(m)-590(seeker)-8.6(s)-593.8(had)-594.5(no)]TJ
0 -1.0528 TD
[(incre)-8.6(ased)-244.1(risk)-241.5(of)-236.4(defaul)-9.4(ting)-241.1(when)-240.7(taki)-8.2(ng)-234.8(other)-247.2(risk)-241.5(factors)]TJ
0 -1.0471 TD
[(into)-605.3(account)-8.9(.)-597.9(V)103.4(ery)-601.8(high)-597.2(rates)-607.3(were)-601.2(observ)-7.8(ed)-599.4(among)]TJ
0 -1.0527 TD
[(pris)-8.2(oners.)-291.9(Defau)-10.1(lting)-289.8(was)-292.3(less)-292.7(likely)-291(if)-290(the)-289.6(diagno)-7.4(sis)-291.6(was)]TJ
T*
[(con)-8.4(firmed)-338.1(by)-337.3(bacteriol)-11.1(ogy)60.3(.)]TJ
1.0015 -1.0471 TD
[(Ho)11.6(me)17.7(le)18.4(ss)-288.4(pa)20.8(ti)16.5(en)15.1(t)13.9(s)0(,)-286.9(s)0(a)13.9(i)13.9(l)0(o)13.2(r)0(s)18.4(,)-296.3(an)20.8(d)-296.7(t)0(r)17.3(a)0(v)20.8(e)0(l)18.4(l)0(e)12.8(r)0(s)-283.2(f)0(r)18(o)0(m)-289.2(e)0(n)15.1(d)0(e)20.8(m)0(i)15.7(c)]TJ
-1.0015 -1.0527 TD
[(ar)13.5(ea)20.4(s)-423.1(h)0(a)15.1(d)-421.9(in)13.2(cr)19.2(ea)20.4(se)14(d)-421.9(r)0(i)17.3(s)0(k)14.4(s)-423.1(of)-412.8(de)15.1(fa)19.2(ul)18.9(ti)16.5(ng)-416.9(ac)20.4(co)15.1(rd)19.6(in)18.9(g)-427.6(t)0(o)-413.6(t)0(h)18.9(e)]TJ
0 -1.0471 TD
[(in)13.2(cl)18.4(us)20(iv)18.9(e)-268.6(d)0(e)15.1(f)0(i)17.3(n)0(i)18.9(t)0(i)16.5(o)0(n)15.5(.)-267.8(H)12.4(o)0(w)11.6(e)0(v)20.8(e)0(r)47.7(,)-267.8(wh)17.3(en)-258(th)13.2(os)20(e)-268.6(r)0(e)19.2(p)0(o)15.5(r)0(t)17.3(e)0(d)20.8(l)0(y)-260(c)0(o)15.1(n)0(-)]TJ
0 -1.0527 TD
[(ti)16.5(nu)15.5(in)18.9(g)-376.3(t)0(r)17.3(e)0(a)14.7(t)0(m)21.4(e)0(n)15.1(t)-378.7(el)18.5(se)19.6(wh)17.3(er)13.5(e)-376.8(w)12.4(er)13.5(e)-376.8(e)0(x)20.8(c)0(l)12.8(u)0(d)21.2(e)0(d)-366.1(a)0(s)-367.3(d)0(e)15.1(f)0(a)19.2(u)0(l)13.2(t)0(e)18.4(r)0(s)18.5(,)]TJ
0 -1.0471 TD
[(re)13.5(la)18.4(ti)16.5(ve)-485.6(ri)17.3(sk)20(s)-497(w)0(e)16.9(r)0(e)-487.2(n)0(o)21.2(t)-498.2(si)17.7(gn)21.2(if)17.3(ic)12.8(an)20.8(tl)16.5(y)-495.8(i)0(n)18.8(c)0(r)19.2(e)0(a)14.7(s)0(e)19.6(d)0(:)-487.6(a)0(d)20.8(j)0(u)13.2(s)0(t)17.7(e)0(d)]TJ
0 -1.0527 TD
[(ha)15.1(za)14.7(rd)-259.2(ra)19.2(ti)16.5(os)-258.8(fo)19.6(r)-269.8(t)0(h)18.9(e)-268.6(ho)21.2(me)12(le)18.4(ss)-260(we)16.9(re)-259.6(1.)21.6(5)-268.2(\()0(9)13.9(5)0(%)-260(C)11.6(I)-269.8(0)0(.)15.9(8)0(\261)21.2(2)0(.)15.9(8)0(\))19.6(,)]TJ
0 -1.0471 TD
[(fo)13.9(r)-395(s)0(a)19.6(i)0(l)16.5(o)0(r)13.9(s)-394.6(1.)21.6(9)-399.1(\()0(9)19.6(5)0(%)-385.2(C)0(I)-389.1(0)0(.)15.9(8)0(\261)21.2(4)0(.)15.9(7)0(\))-384.4(a)0(n)15.1(d)-393.4(fo)19.6(r)-400.7(t)0(r)17.3(a)0(v)20.8(e)0(l)18.5(l)0(e)12.8(r)0(s)-385.6(f)0(r)18(o)0(m)]TJ
0 -1.0527 TD
[(en)15.1(de)15.1(m)13.2(i)0(c)-254.7(a)0(r)13.5(e)0(a)20.4(s)-263.7(0.)21.6(8)-262.5(\()0(9)13.9(5)0(%)-254.3(C)11.6(I)-264.1(0)0(.)15.9(3)0(\261)21.2(1)0(.)15.9(9)0(\))19.6(.)-262.1(It)-255.9(is)-249.8(li)16.5(ke)15.1(ly)-248.6(th)13.2(at)-254.7(m)13.2(a)0(n)15.1(y)]TJ
0 -1.0471 TD
[(of)-276.3(t)13.9(h)0(e)15.1(s)0(e)-270.6(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-272.6(w)0(e)16.9(r)0(e)-271(t)0(r)17.3(a)0(n)15.1(s)0(f)18.4(e)0(r)19.2(r)0(e)13.5(d)-279.6(ab)20.8(ro)14(ad)-269.4(\(a)19.2(ll)-273.7(si)17.7(x)-279.6(h)0(o)15.5(m)0(e)17.7(l)0(e)18.4(s)0(s)]TJ
0 -1.0527 TD
[(an)15.1(d)-541.4(2)0(4)-536.4(s)0(a)13.9(i)13.9(l)0(o)13.2(r)0(s)-533.5(a)0(n)15.1(d)-541.4(17)-536.4(of)-532.3(20)-536.4(tr)17.3(av)15.1(el)18.4(le)18.4(rs)-533.5(fr)12.3(om)-533.9(en)15.1(de)20.8(mi)15.7(c)]TJ
0 -1.0471 TD
[(co)15.1(un)15.5(t)13.9(r)0(i)17.3(e)0(s)-333.2(w)0(h)11.6(o)-336.5(we)16.9(re)-333.6(re)13.5(po)21.2(rt)17.3(ed)15.1(ly)-334(co)20.8(nt)18.8(in)13.2(ui)18.8(ng)-331.6(tr)17.3(ea)14.7(tm)15.7(en)20.8(t)-344.6(e)0(l)18.4(s)0(e)19.6(-)]TJ
0 -1.0528 TD
[(wh)17.3(er)13.5(e)-428(w)0(e)16.9(r)0(e)-418.9(o)0(f)-418.5(n)0(o)21.2(n)0(-)13.9(D)12.4(ut)13.2(ch)-417.3(na)20.8(ti)16.5(on)15.5(al)18.5(it)16.5(y\))19.6(.)-427.2(P)11.4(at)12.8(ie)18.5(nt)18.9(s)-428.8(d)0(e)20.8(t)0(e)12.8(c)0(t)18.4(e)0(d)]TJ
T*
[(th)13.2(ro)19.6(ug)15.5(h)-512.9(s)0(c)19.6(r)0(e)13.5(e)0(n)20.8(i)0(n)18.9(g)-518.6(ha)20.8(d)-518.6(a)0(n)-508.4(i)13.9(nc)15.1(re)19.2(as)13.9(ed)-502.7(ri)17.3(sk)-509.2(of)-503.9(de)15.1(fa)19.2(ul)13.2(ti)22.2(ng)15.5(,)]TJ
0 -1.0471 TD
[(wh)17.3(ic)12.8(h)-279.6(w)0(a)16.9(s)-280.8(ju)18.9(st)-272.6(si)17.7(gn)21.2(if)17.3(ic)18.4(an)15.1(t)-282(a)0(c)20.4(c)0(o)15.1(r)0(d)19.6(i)0(n)18.9(g)-279.6(to)-271.4(th)13.2(e)-280(r)0(e)19.2(s)0(t)17.7(r)0(i)17.3(c)0(t)18.5(i)0(v)13.2(e)-280(de)20.8(f-)]TJ
0 -1.0528 TD
[(in)13.2(it)22.2(io)13.2(n,)-319.8(bu)21.2(t)-333.2(w)0(a)16.9(s)-332(no)15.5(t)-327.5(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(t)-327.5(ac)14.7(co)20.8(rd)14(in)18.8(g)-330.8(t)0(o)-322.6(t)0(h)18.8(e)-331.2(in)18.9(cl)18.5(us)14.3(iv)18.9(e)]TJ
0 -1.0471 TD
[(de)15.1(fi)17.3(ni)18.9(ti)16.5(on)-314.5(\(t)17.3(ab)15.1(le)-311.6(1\).)]TJ
1.0015 -1.0528 TD
[(Wh)14.4(en)-428.7(ta)18.4(ki)13.2(ng)-428.3(th)18.9(e)-439.3(a)0(b)20.8(o)0(v)15.5(e)-439.3(va)20.8(ri)17.3(ab)15.1(le)18.4(s)-440.1(i)0(n)18.9(t)0(o)-430.7(a)0(c)20.4(c)0(o)15.1(u)0(n)21.2(t)-441.3(in)-430.7(th)18.9(e)]TJ
-1.0015 -1.0471 TD
[(mu)12.4(lt)16.5(i)13.9(v)0(a)15.1(r)0(i)17.3(a)0(t)18.4(e)-268.6(an)20.8(al)12.8(ys)20(is)17.7(,)-267.8(n)0(o)-257.6(s)0(i)17.7(g)0(n)21.2(i)0(f)17.3(i)0(c)12.8(a)0(n)20.8(t)-264.9(as)13.9(so)20(ci)18.5(at)12.8(io)18.9(n)-268.2(w)12.4(as)-259.2(fo)19.6(un)15.5(d)]TJ
0 -1.0527 TD
[(be)15.1(tw)14.9(ee)20.4(n)-547.1(d)0(e)20.8(f)0(a)13.5(u)0(l)18.9(t)0(i)16.5(n)0(g)-530.8(a)0(n)15.1(d)-541.4(th)18.9(e)-547.5(f)0(o)19.6(l)0(l)16.5(o)0(w)17.3(i)0(n)18.9(g)-547.1(va)20.8(ri)17.3(ab)15.1(le)18.4(s:)-534.3(ur)19.6(ba)15.1(n)]TJ
0 -1.0471 TD
[(re)13.5(si)17.7(de)20.8(nc)15.1(e,)-320.2(ha)15.1(vi)18.9(ng)-320.2(de)15.1(fa)19.2(ul)18.9(te)12.8(d)-330.8(f)0(r)18(o)0(m)-323.3(p)0(r)19.6(e)0(v)15.1(i)0(o)18.8(u)0(s)-321.4(c)0(u)15.1(r)0(a)19.2(t)0(i)16.5(v)0(e)-320.6(t)0(u)18.8(b)0(e)15.1(r)20.4(-)]TJ
0 -1.0527 TD
[(cu)15.1(lo)18.8(si)17.7(s)-326.3(t)0(r)17.3(e)0(a)14.7(t)0(m)15.7(e)0(n)20.8(t)0(,)-322.2(l)0(o)18.8(c)0(a)14.7(l)13.9(iz)12.8(at)18.5(io)18.8(n)-325.1(o)0(f)-321.8(t)0(u)18.9(b)0(e)15.1(r)0(c)19.2(u)0(l)18.9(o)0(s)14.4(i)0(s)17.7(,)-324.7(hu)15.5(ma)17.7(n)-325.1(i)0(m)15.7(-)]TJ
0 -1.0471 TD
[(mu)12.4(no)21.2(de)15.1(fi)17.3(ci)18.4(en)15.1(cy)-229.6(vi)18.9(ru)13.9(s)-241(i)13.9(nf)13.9(ec)20.4(ti)16.5(on)-234.8(an)20.8(d)-239.8(a)0(d)15.1(d)0(i)18.8(c)0(t)18.4(i)0(o)13.2(n)-239.8(to)-231.5(al)18.4(co)15.1(ho)21.2(l)-242.1(o)0(r)]TJ
0 -1.0528 TD
[(dr)13.9(ug)21.2(s.)]TJ
1.0015 -1.0527 TD
[(In)-384.4(or)19.6(de)15.1(r)-389.3(t)0(o)-379.5(a)0(i)18.4(d)-393.4(th)18.9(e)-388.1(p)0(r)13.9(e)0(d)20.8(i)0(c)18.4(t)0(i)16.5(o)0(n)-382.8(o)0(f)-378.7(d)0(e)15.1(f)0(a)19.2(u)0(l)18.9(t)0(i)16.5(n)0(g)-382.8(\()0(u)19.6(s)0(i)17.7(n)0(g)-382.8(t)0(h)18.9(e)]TJ
-1.0015 -1.0471 TD
[(in)13.2(cl)18.4(us)20(iv)18.9(e)-206(d)0(e)20.8(f)0(i)17.3(n)0(i)13.2(t)0(i)22.2(o)0(n)15.5(\))-201.5(at)-197.8(th)18.9(e)-200.3(s)0(t)17.7(a)0(r)13.5(t)-202.3(of)-190.9(tr)17.3(ea)14.7(tm)15.7(en)20.8(t)-202.3(a)0(n)15.1(d)-199.9(to)-197.4(ev)20.8(al)12.8(ua)20.8(te)]TJ
0 -1.0527 TD
[(th)13.2(e)-422.3(p)0(o)21.2(s)0(s)18.9(i)0(b)13.2(l)0(e)-414(i)0(m)15.7(p)0(a)20.8(c)0(t)-414(o)0(f)-412.8(t)0(h)18.8(e)-422.3(in)13.2(cr)19.2(ea)14.7(se)19.6(d)-421.9(a)0(t)18.5(t)0(e)18.4(n)0(t)13.2(i)0(o)18.8(n)0(,)-410.9(i)0(n)-413.6(r)0(e)13.5(c)0(e)20.4(n)0(t)]TJ
0 -1.0471 TD
[(ye)15.1(ar)19.2(s,)-343.8(to)-339.7(th)13.2(e)-348.3(f)0(o)13.9(l)0(l)22.2(o)0(w)11.6(-)0(u)19.6(p)-353.6(of)-338.9(as)13.9(yl)18.9(um)-340.4(se)13.9(ek)20.8(er)13.5(s,)-338.1(a)-354(s)0(i)17.7(m)0(p)18.1(l)0(e)-345.7(c)0(l)18.4(a)0(s)19.6(-)]TJ
0 -1.0527 TD
[(si)17.7(fi)17.3(ca)14.7(ti)16.5(on)-388.5(wa)16.9(s)-400.3(u)0(s)14.4(e)0(d)20.8(.)-404.4(P)11.4(a)0(t)18.5(i)0(e)18.4(n)0(t)13.2(s)-400.3(w)12.4(e)0(r)13.5(e)-399.5(ca)14.7(t)13.9(e)0(g)15.1(o)0(r)19.6(i)0(z)12.8(e)0(d)-388.9(i)0(n)18.8(t)0(o)-390.9(t)0(h)13.2(r)0(e)19.2(e)]TJ
0 -1.0471 TD
[(gr)13.9(ou)21.2(ps)14.4(:)-230.8(1)0(\))-225.1(a)0(s)19.6(y)0(l)18.9(u)0(m)-226.6(s)0(e)19.6(e)0(k)15.1(e)0(r)19.2(s)0(;)-221.3(2)0(\))-225.1(o)0(t)18.9(h)0(e)15.1(r)-230(hi)18.9(gh)15.5(-r)18(is)17.7(k)-234.1(g)0(r)19.6(o)0(u)15.5(p)0(s)-219(\()0(o)14(t)0(h)18.8(e)0(r)]TJ
0 -1.0528 TD
[(re)13.5(ce)20.4(nt)-311.2(im)15.7(mi)15.7(gr)19.6(an)15.1(t)13.9(s)0(,)-309.6(i)0(l)16.5(l)0(e)18.4(g)0(a)15.1(l)-316.1(im)15.7(mi)15.7(gr)19.6(an)15.1(ts)17.7(,)-313.4(t)0(h)18.9(e)-319.8(ho)15.5(me)17.7(le)18.4(ss)18.8(,)-319(p)0(r)19.6(i)0(s)17.7(-)]TJ
0 -1.0471 TD
[(on)15.5(er)19.2(s)-297.9(a)0(n)15.1(d)-296.7(na)15.1(t)13.9(i)0(o)13.2(n)0(a)20.8(l)0(s)-289.6(f)0(r)18(o)0(m)-289.2(E)0(a)16.7(s)0(t)17.7(e)0(r)13.5(n)-296.7(Eu)17.1(ro)19.6(pe)-292.2(in)18.9(cl)18.5(ud)15.5(i)13.9(n)0(g)-291.8(Y)114.8(ug)15.5(o-)]TJ
0 -1.0528 TD
[(sl)17.7(av)15.1(ia)-590.4(an)20.8(d)-598.3(f)0(o)19.6(r)0(m)10.8(e)0(r)-584(Y)109.1(ug)21.2(os)14.4(la)18.4(vi)18.9(an)-588.1(te)12.8(rr)18(it)16.5(or)19.6(ie)18.4(s\))18.4(;)-600.7(a)0(n)20.8(d)-598.3(3\))-589.2(al)18.5(l)]TJ
0 -1.0471 TD
[(ot)13.2(he)20.8(rs)18.4(.)-290.6(O)0(f)-285.9(t)0(h)18.8(e)-291.4(1,)21.6(43)15.5(7)-291(a)0(s)19.6(y)0(l)13.2(u)0(m)-277.8(s)0(e)13.9(e)0(k)20.8(e)0(r)13.5(s)0(,)-281.2(1)0(8)21.2(9)-291(\(1)13.9(3%)18.9(\))-292.6(d)0(e)20.8(f)0(a)13.5(u)0(l)18.8(t)0(e)18.4(d)]TJ
0 -1.0528 TD
[(wi)14.9(th)18.9(in)-504.7(1)-518.6(y)0(r)53.8(,)-518.2(gi)18.9(vi)18.9(ng)-502.3(a)-519(K)12.4(ap)15.1(la)18.5(n-)19.6(Me)13.2(ie)18.4(r)-514.5(p)0(r)19.6(o)0(b)15.5(a)0(b)15.1(i)13.9(li)16.5(ty)-504.7(of)-509.6(de)20.8(-)]TJ
T*
[(fa)13.5(ul)18.9(ti)16.5(ng)-269(of)-264.9(17)15.5(%)-276.3(\()0(9)19.6(5)0(%)-271.3(C)0(I)-269.6(1)0(4)15.5(\261)0(1)21.2(9)0(%)13.2(\))0(.)-264.5(O)0(f)-268.8(t)0(h)18.8(e)-280(83)21.2(6)-279.6(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-266.9(i)0(n)]TJ
0 -1.0471 TD
[(ot)13.2(he)20.8(r)-531.6(h)0(i)18.9(g)0(h)15.5(-)0(r)18(i)0(s)17.7(k)-530(gr)19.6(ou)15.5(ps)20(,)-529.6(1)0(8)15.5(6)-530(\(2)19.6(2%)13.2(\))-531.6(d)0(e)20.8(f)0(a)13.5(u)0(l)18.9(t)0(e)18.4(d)0(,)-519(g)0(i)18.8(v)0(i)13.2(n)0(g)-519.4(a)]TJ
0 -1.0528 TD
[(Ka)16.9(pl)13.2(an)20.8(-M)17.7(ei)12.8(er)-367.7(pr)19.6(ob)15.5(ab)15.1(il)22.2(it)16.5(y)-382(o)0(f)-367.3(d)0(e)15.1(f)0(a)19.2(u)0(l)18.9(t)0(i)16.5(n)0(g)-371.4(o)0(f)-367.3(2)0(9)15.5(%)-378.7(\(9)19.6(5%)-373.8(C)11.6(I)]TJ
0 -1.0471 TD
[(24)15.5(\2613)15.5(4%)18.9(\).)-241.7(Of)-246.1(th)18.8(e)-257.2(5)0(,)21.6(2)0(5)15.5(6)-251.2(ot)18.9(he)15.1(r)-252.7(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)17.7(,)-250.8(34)15.5(3)-251.2(\()0(7)19.6(%)0(\))-244.5(d)0(e)15.1(f)0(a)19.2(u)0(l)13.2(t)13.9(ed)15.1(,)]TJ
0 -1.0528 TD
[(gi)13.2(vi)18.9(ng)-462.5(a)-473.5(K)0(a)16.9(p)0(l)18.8(a)0(n)15.1(-)0(M)17.7(e)0(i)18.5(e)0(r)-464.5(p)0(r)19.6(o)0(b)15.5(a)0(b)20.8(i)0(l)16.5(i)0(t)16.5(y)-473.1(of)-464.1(de)20.8(fa)13.5(ul)18.9(ti)16.5(ng)-462.5(of)-464.1(9%)]TJ
0 -1.0471 TD
[(\(9)13.9(5%)-339.6(CI)-337.9(8\261)15.5(10)21.2(%\))11.6(.)-347.5(I)0(n)-338.9(a)0(l)18.4(l)-344.6(th)13.2(re)19.2(e)-348.3(r)0(i)17.3(s)0(k)-338.5(g)0(r)19.6(o)0(u)15.5(p)0(s)20(,)-347.5(de)15.1(fa)19.2(ul)13.2(t)13.9(i)0(n)13.2(g)-347.9(oc)20.8(-)]TJ
0 -1.0527 TD
[(cu)15.1(rr)18(ed)-314.9(re)13.5(gu)21.2(la)18.5(rl)17.3(y)-325.1(o)0(v)15.5(e)0(r)-316.5(t)0(h)18.9(e)-325.5(tr)17.3(ea)20.4(tm)15.7(en)15.1(t)-321.8(p)0(e)15.1(r)0(i)17.3(o)0(d)-314.5(\()0(f)18(i)0(g)18.8(.)-324.7(1\).)]TJ
1.0015 -1.0471 TD
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[(tr)17.3(ea)14.7(tm)21.4(en)15.1(t)-344.6(a)0(n)20.8(d)-342.2(de)20.8(fa)13.5(ul)18.9(ti)16.5(ng)-331.6(ha)15.1(s)-337.7(d)0(e)15.1(c)0(r)19.2(e)0(a)14.7(s)0(e)19.6(d)-342.2(ov)15.5(er)-327.9(th)13.2(e)-342.6(p)0(a)20.8(s)0(t)-335.2(f)0(e)19.2(w)]TJ
0 -1.0471 TD
[(ye)15.1(ar)19.2(s.)]TJ
1.0015 -1.0527 TD
[(Na)16.9(ti)16.5(on)15.5(al)-271.8(ra)19.2(te)18.4(s)-280.8(o)0(f)-276.3(d)0(e)20.8(f)0(a)19.2(u)0(l)13.2(t)0(i)16.5(n)0(g)-269(f)0(r)18(o)0(m)-272.1(t)0(u)13.2(b)0(e)20.8(r)0(c)19.2(u)0(l)13.2(o)0(s)20(i)0(s)-272.6(t)0(r)17.3(e)0(a)14.7(t)13.9(me)12(nt)]TJ
-1.0015 -1.0471 TD
[(ar)19.2(e)-302.8(n)0(o)15.5(t)-304.7(w)12.4(i)0(d)13.2(e)0(l)18.5(y)-302.4(re)19.2(po)15.5(rt)17.3(ed)-292.2(in)-294.1(Eu)17.1(ro)19.6(pe)15.1(.)-302(T)12.2(he)-297.8(pu)21.2(bl)13.2(i)13.9(s)0(h)14.4(e)0(d)-292.2(r)0(a)13.5(t)13.9(es)-299(of)]TJ
0 -1.0528 TD
[(de)15.1(fa)19.2(ul)18.9(ti)16.5(ng)-263.3(ar)19.2(e)-274.3(u)0(s)20(u)0(a)15.1(l)0(l)16.5(y)-268.2(in)-265.7(th)18.9(e)-274.3(r)0(a)19.2(n)0(g)15.5(e)-268.6(5\261)15.5(15)21.2(%)-276.3([)0(8)19.6(\26110],)-283.9(and)-287.2(are)]TJ
0 -1.0471 TD
[(thus)-450.5(sim)-9(ilar)-453.7(to)-447.8(those)-457.3(observed)-453.6(in)-453.5(the)-448.9(presen)-8.2(t)-452.7(study)60.9(.)-449.9(A)]TJ
0 -1.0528 TD
[(limita)-12(tion)-269.6(in)-265.7(compa)-7.8(ring)-268.8(the)-272.5(resul)-9.4(ts)-266.9(of)-270.6(these)-270(studies)-274.7(is)-266.9(that)]TJ
25.1977 20.0592 TD
[(the)-295.3(selec)-8.6(tion)-298(of)-293.3(patients)-299.8(and)-298.6(duration)-297.4(of)-287.7(follow-up)-303.3(varies)]TJ
0 -1.0528 TD
[(betw)-9.8(een)-384.4(them.)-390.6(The)-382.4(recent)-391(intr)-9.4(oduction)-386.8(of)-384.4(stand)-7.8(ard)-385.6(def-)]TJ
T*
[(inition)-9.2(s)-440.1(and)-440.9(metho)-9.7(ds)-435.2(in)-442.1(European)-445.1(tuber)-8.2(culos)-7.8(is)-437.6(surveil-)]TJ
T*
[(lance)-343.2(shoul)-7.4(d)-336.5(facilitate)-347.1(more)-338.2(direc)-8.6(t)-338.9(compariso)-10.3(ns)-338.5(between)]TJ
T*
[(cou)-8.4(ntries)-336.9(in)-334(the)-340.8(near)-335.5(futur)-9.4(e)-331.2([6].)]TJ
1.0015 -1.0471 TD
[(No)11.6(nc)20.8(om)18.1(pl)13.2(i)13.9(a)0(n)15.1(c)0(e)-463.3(w)0(i)14.9(t)0(h)-459.2(t)0(h)18.9(e)0(r)13.5(a)0(p)20.8(y)-473.1(is)-460.3(as)19.6(so)14.4(ci)18.5(at)18.4(ed)-462.9(wi)14.9(th)-459.2(po)15.5(or)]TJ
-1.0015 -1.0528 TD
[(tr)17.3(ea)14.7(tm)15.7(en)20.8(t)-458.4(o)0(u)15.5(t)13.9(co)15.1(me)17.7(,)-455.6(a)0(c)14.7(q)0(u)21.2(i)0(r)17.3(e)0(d)-451.5(d)0(r)19.6(u)0(g)-445.4(r)0(e)19.2(s)0(i)12(s)0(t)17.7(a)0(n)20.8(c)0(e)-446.2(a)0(n)15.1(d)-456(an)-445.8(in)18.8(-)]TJ
T*
[(cr)13.5(ea)20.4(se)13.9(d)-245.5(r)0(i)17.3(s)0(k)-236(o)0(f)-242.1(r)0(e)19.2(l)0(a)18.4(p)0(s)14.4(e)-245.9([1)48.1(1\26117].)-250.5(Directly)-264.3(o)-6.5(bserved)-259.3(thera)-8.6(py)]TJ
T*
[(has)-316.9(been)-316.8(an)-314.9(imp)-7.8(ortant)-318.6(strategy)-321.8(in)-316.9(improvi)-9.1(ng)-314.5(complianc)-10.3(e)]TJ
T*
[(and)-292.9(treat)-11(ment)-293.5(outcom)-10.5(e,)-286.1(in)-294.1(particula)-11.1(r)-292.6(i)0(n)-288.4(the)-295.3(USA)-293.9([12,)-294.5(15,)]TJ
T*
[(18,)-223.8(19].)-226.2(In)-225.1(the)-227(Netherla)-11.9(nds,)-220.1(direc)-8.6(tly)-223.3(observ)-7.8(ed)-223.9(thera)-8.6(py)-223.5(was)]TJ
T*
[(not)-414.4(used)-408.7(wi)-7.8(dely)-409.9(durin)-7.8(g)-404.8(the)-414.8(study)-411.4(perio)-8.2(d.)-405.2(In)-412.8(the)-409.1(perio)-8.2(d)]TJ
T*
[(199)-8(4\2611996,)-443.1(it)-444.5(was)-446(given)-444.8(to)-442.1(~5%)-446(of)-441.3(pati)-8.2(ents)-445.2(\(personal)]TJ
T*
[(comm)-9.8(unication,)-578.6(M.)-572.2(V)103.4(erhagen)-8.1(,)-569.4(Net)-9(herlands)-575.4(School)-575.6(of)]TJ
0 -1.0584 TD
[(Pu)-6.4(blic)-383.8(Health,)-390(Ut)-7.8(recht\).)-386.9(It)-386.8(appears)-390.6(that,)-384.2(for)-386.7(most)-385.3(tuber-)]TJ
0 -1.0527 TD
[(culos)-7.8(is)-449(pati)-8.2(ents)-450.9(in)-453.5(the)-448.9(Netherl)-10.7(ands,)-454.6(adequat)-8.9(e)-445(treat)-11(ment)]TJ
T*
[(resul)-9.4(ts)-409.1(can)-412.8(be)-411.7(obtai)-9(ned)-412.4(without)-420.4(generally)-418.5(applying)-415.3(dir-)]TJ
T*
[(ectl)-8.6(y)-558.4(observed)-561.7(thera)-8.6(py)61.1(.)-558.1(However)24.2(,)-558.1(results)-566.5(in)-555.9(high-)-7.8(risk)]TJ
T*
[(groups)-382.9(are)-380.3(not)-380.2(excellent)-385.5(and)-378.3(show)-378.1(no)-377.1(sign)-382.2(of)-378.7(improve-)]TJ
T*
[(ment)-9(.)-387.3(Measu)-7.8(res)-398.1(to)-390.9(improve)-399.8(treatmen)-11.1(t)-390.1(outcom)-10.5(e)-388.1(i)0(n)-390.9(these)]TJ
T*
[(high-)-7.8(risk)-281.4(groups)-280.5(are)-283.5(being)-279.8(consi)-7.8(dered,)-279.7(and)-281.5(will)-281.6(includ)-9.7(e)-274.3(a)]TJ
T*
[(wi)-7.8(der)-334.3(appli)-9(cation)-340.2(of)-333.2(direc)-8.6(tly)-337.1(observed)-339.7(thera)-8.6(py)61.1(.)]TJ
1.0015 -1.0471 TD
[(In)-225.1(th)18.8(e)-228.8(p)0(r)13.9(e)0(s)19.6(e)0(n)20.8(t)-230.8(st)17.7(ud)15.5(y)-228.4(a)0(l)18.5(c)0(o)15.1(h)0(o)21.2(l)-230.8(an)15.1(d)-228.4(d)0(r)19.6(u)0(g)-223.5(a)0(d)20.8(d)0(i)13.2(c)0(t)18.4(s)-229.6(sh)20(ow)17.3(ed)-223.9(no)]TJ
-1.0015 -1.0527 TD
[(in)13.2(cr)19.2(ea)14.7(se)19.6(d)-376.3(r)0(a)13.5(t)0(e)18.4(s)-377.5(of)-373(de)20.8(fa)13.5(ul)18.9(t,)-367.7(co)15.1(nt)18.9(ra)13.5(ry)-367.3(to)-373.8(re)19.2(po)21.2(rt)17.3(s)-383.2(f)0(r)18(o)0(m)-368.9(o)0(t)13.2(h)0(e)20.8(r)]TJ
T*
[(co)15.1(un)15.5(t)13.9(r)0(i)17.3(e)0(s)-196.6([)0(1)13.9(3)0(,)-200.3(14].)-220.5(The)-217.4(reason)-218.7(for)-216(the)-215.6(relat)-11(ively)-213.8(low)-219.2(rate)-218.4(of)]TJ
T*
[(defaul)-9.4(t)-407.2(i)0(n)-402.3(these)-412.2(groups)-405.7(in)-407.9(the)-403.4(Net)-9(herlands)-410.4(may)-409.9(be)-406(that)]TJ
T*
[(they)-335.9(have)-328.2(been)-333.9(recogni)-10.1(zed)-327.5(as)-327.5(high-)-7.8(risk)-332.6(groups)-331.7(for)-329.8(some)]TJ
T*
[(time)-455.2(and)-452.3(are)-448.6(follow)-9.2(ed-up)-455.4(much)-450.5(more)-452.1(close)-8.2(ly)-447.8(than)-449.7(the)]TJ
T*
[(ave)-8.8(rage)-233.1(pati)-8.2(ent.)-238.8(As)-234.3(presen)-8.2(t)-230.8(resul)-9.4(ts)-232.7(appear)-240.7(adequat)-8.9(e)-234.5(i)0(n)-237.2(this)]TJ
T*
[(group,)-290.3(they)-290.4(may)-290.4(not)-289.2(be)-286.5(a)-285.7(priority)-295.3(group)-289.9(for)-284.3(exp)-8.4(ansion)-287.4(of)]TJ
T*
[(direc)-8.6(tly)-337.1(observ)-7.8(ed)-332(thera)-8.6(py)61.1(.)]TJ
1.0015 -1.0528 TD
[(Fo)16.3(r)-508.8(p)0(a)15.1(t)0(i)22.2(e)0(n)15.1(t)0(s)-500.2(w)0(h)17.3(o)-507.2(wi)14.9(sh)-497.8(to)-499(be)-497(tr)17.3(an)15.1(sf)18.4(er)19.2(re)19.2(d)-507.2(a)0(b)15.1(r)0(o)19.6(a)0(d)15.1(,)-506.8(in)18.8(-)]TJ
-1.0015 -1.0527 TD
[(cl)12.8(ud)21.2(in)18.8(g)-268.2(s)0(a)13.9(i)0(l)16.5(o)0(r)19.6(s)-269.4(an)15.1(d)-268.2(t)0(r)17.3(a)0(v)20.8(e)0(l)12.8(l)13.9(er)13.5(s)-269.4(f)0(r)18(o)0(m)-260.8(e)0(n)15.1(d)0(e)20.8(m)0(i)15.7(c)-268.6(co)15.1(un)21.2(tr)17.3(ie)12.8(s,)-258.4(in)18.8(c-)]TJ
T*
[(om)12.4(pl)18.9(et)18.5(e)-268.6(i)0(n)18.9(f)0(o)13.9(r)0(m)16.5(a)0(t)18.4(i)0(o)18.8(n)-268.2(on)-257.6(th)13.2(e)-268.6(o)0(u)21.2(t)0(c)18.4(o)0(m)12.4(e)-268.6(of)-259.2(tr)17.3(ea)20.4(tm)15.7(en)15.1(t)-270.6(m)0(a)17.7(y)-268.2(no)21.2(t)]TJ
T*
[(be)-366.1(co)20.8(mp)18.1(le)12.8(te)18.4(ly)-362.4(av)20.8(oi)18.9(da)15.1(bl)18.9(e)-371.1(a)0(n)15.1(d)0(,)-359.6(i)0(n)-362.4(t)13.9(he)-366.1(an)20.8(al)18.5(ys)14.4(is)17.7(,)-370.3(t)0(h)18.8(e)0(s)19.6(e)-371.1(ha)15.1(ve)]TJ
T*
[(no)15.5(t)-344.6(b)0(e)20.8(e)0(n)-332(i)0(n)13.2(c)0(l)18.5(u)0(d)21.2(e)0(d)-337.7(i)13.9(n)-342.2(t)0(h)13.2(e)-342.6(")13.4(o)0(t)18.9(h)0(e)15.1(r)-343.8(hi)18.9(gh)15.5(-r)18(is)17.7(k)-342.2(g)0(r)19.6(o)0(u)15.5(p)0(s)20(")-339.5(fo)13.9(r)-343.8(d)0(e)20.8(-)]TJ
T*
[(fa)13.5(ul)18.9(ti)16.5(ng)21.2(.)-336.1(H)0(o)17.3(w)0(e)16.9(v)0(e)15.1(r)37.5(,)-336.1(r)0(e)19.2(c)0(e)20.4(n)0(t)-328.3(i)0(m)15.7(m)0(i)15.7(g)0(r)13.9(a)0(n)20.8(t)0(s)17.7(,)-336.1(il)16.5(le)18.4(ga)15.1(l)-333.2(i)0(m)15.7(m)0(i)15.7(g)0(r)19.6(a)0(n)15.1(t)0(s)17.7(,)]TJ
T*
[(th)13.2(e)-382.4(h)0(o)21.2(m)0(e)17.7(l)0(e)12.8(s)0(s)-373.8(a)0(n)20.8(d)-382(pr)13.9(is)17.7(on)21.2(er)13.5(s)-383.2(a)0(l)18.5(l)-384.4(sh)20(ow)17.3(ed)-371.8(hi)13.2(gh)-371.4(ra)19.2(te)12.8(s)-377.5(o)0(f)-378.7(d)0(e)20.8(-)]TJ
T*
[(fa)13.5(ul)18.9(ti)16.5(ng)21.2(,)-313.4(a)0(n)20.8(d)-308.1(an)-303.5(ex)20.8(pa)15.1(ns)20(io)18.9(n)-308.1(o)0(f)-304.7(m)0(e)17.7(a)0(s)19.6(u)0(r)14(e)0(s)-299(t)0(o)-299.8(r)0(e)19.2(d)0(u)15.5(c)0(e)-298.2(d)0(e)15.1(f)0(a)19.2(u)0(l)18.9(t)0(-)]TJ
T*
[(ti)16.5(ng)-360(ra)19.2(te)18.4(s)-366.2(a)0(p)15.1(p)0(e)20.8(a)0(r)13.5(s)-366.2(in)18.9(di)18.9(ca)14.7(te)18.4(d)-365(f)0(o)13.9(r)-366.6(t)13.9(h)0(e)15.1(s)0(e)-355.9(g)0(r)14(o)0(u)21.2(p)0(s)14.4(.)-364.6(In)-355.9(ad)15.1(di)18.9(ti)16.5(on)]TJ
T*
[(to)-698.2(di)18.9(re)19.2(ct)12.8(ly)-692.5(ob)15.5(se)19.6(rv)19.6(ed)-696.2(th)18.8(er)13.5(ap)20.8(y)67.5(,)-700.3(im)15.7(pr)19.6(ov)15.5(ed)-696.2(co)20.8(-o)13.9(rd)19.6(in)18.9(at)12.8(io)18.8(n)]TJ
T*
[(be)15.1(tw)14.9(ee)20.4(n)-376.3(m)0(u)18.1(n)0(i)13.2(c)0(i)18.4(p)0(a)20.8(l)-378.7(he)15.1(al)18.4(th)-368.1(se)19.6(rv)19.6(ic)12.8(es)-367.3(an)20.8(d)-376.3(p)0(r)13.9(i)0(s)17.7(o)0(n)-365.7(a)0(u)15.1(t)13.9(ho)15.5(ri)17.3(ti)16.5(es)]TJ
ET
0 0 0 1 K
0 J 0 j 0.5 w 3.864 M []0 d
/GS3 gs
1 i 
92.03 642.631 m
92.03 772.381 l
91.905 739.506 m
89.53 739.506 l
91.905 772.13 m
89.53 772.13 l
91.905 707.506 m
89.53 707.506 l
91.905 675.506 m
89.53 675.506 l
92.03 642.881 m
89.53 642.881 l
92.155 642.881 m
281.654 642.881 l
233.779 642.881 m
233.779 641.131 l
257.279 642.881 m
257.279 641.131 l
281.404 642.881 m
281.404 641.131 l
210.279 642.881 m
210.279 641.131 l
186.53 642.881 m
186.53 641.131 l
163.03 642.881 m
163.03 641.131 l
139.405 642.881 m
139.405 641.131 l
115.655 642.881 m
115.655 641.131 l
92.03 642.881 m
92.03 641.131 l
S
BT
/F15 1 Tf
10 0 0 10 89.797 632.631 Tm
0 0 0 1 k
/GS4 gs
[(0)-1683.2(5)11.6(0)-1219.6(100)-982(150)]TJ
8.9858 0.0109 TD
-0.0024 Tc
(200)Tj
2.3791 -0.0109 TD
[(250)-983.4(300)-1000.9(350)-1040(400)]TJ
-11.9791 0.7 TD
0 Tc
(0)Tj
-1.1375 3.2717 TD
(0.25)Tj
0 3.1908 TD
(0.50)Tj
0 3.205 TD
(0.75)Tj
0 3.2575 TD
(1.00)Tj
6.5 -14.775 TD
[(Dur)10(ation of treatment  da)30(ys)]TJ
0 10 -10 0 68.28 657.381 Tm
[(Probability of not def)30(aulting)]TJ
ET
/GS3 gs
92.28 772.13 m
93.905 771.881 l
95.655 771.755 l
98.655 771.631 l
99.78 771.506 l
101.53 771.506 l
103.28 771.256 l
105.155 771.131 l
106.905 770.756 l
108.28 771.005 l
111.03 770.756 l
116.405 770.756 l
117.28 770.381 l
119.03 770.381 l
119.655 770.131 l
123.905 770.006 l
125.155 769.631 l
130.655 769.505 l
131.405 769.381 l
136.905 769.381 l
138.405 769.13 l
143.53 769.006 l
144.655 768.881 l
147.405 768.755 l
148.905 768.506 l
156.655 768.38 l
157.53 768.131 l
160.53 768.005 l
161.155 767.756 l
166.78 767.756 l
167.78 767.506 l
172.155 767.506 l
172.905 767.131 l
173.53 767.131 l
174.28 766.88 l
180.28 766.88 l
180.78 766.505 l
183.405 766.505 l
184.28 766.256 l
193.28 766.13 l
196.905 765.755 l
199.029 765.506 l
203.154 765.506 l
204.029 765.256 l
206.404 765.256 l
207.154 765.005 l
213.904 764.881 l
215.779 764.631 l
226.154 764.506 l
227.279 764.131 l
236.279 764.006 l
237.154 763.381 l
246.529 763.131 l
247.529 762.631 l
264.279 762.506 l
S
[1 1 ]0 d
92.03 772.006 m
96.155 771.256 l
99.905 771.005 l
101.78 770.63 l
103.405 770.131 l
105.655 769.756 l
108.28 769.256 l
110.655 769.256 l
112.155 768.755 l
114.405 768.881 l
116.03 768.38 l
118.28 767.881 l
120.655 767.63 l
122.03 766.756 l
123.78 766.756 l
125.28 766.256 l
127.03 765.755 l
129.03 765.631 l
130.905 765.631 l
133.405 764.631 l
134.655 765.005 l
136.78 764.756 l
139.78 764.506 l
142.155 764.131 l
145.03 764.506 l
146.655 764.256 l
147.905 763.756 l
151.28 763.756 l
152.78 763.131 l
154.78 763.381 l
155.905 763.131 l
158.28 762.881 l
160.78 762.131 l
163.405 761.506 l
165.78 761.256 l
168.28 761.131 l
172.28 761.131 l
174.03 760.506 l
176.03 760.131 l
178.78 760.131 l
181.155 759.756 l
183.405 759.631 l
186.03 759.631 l
187.655 759.256 l
189.654 759.256 l
191.03 758.631 l
193.53 758.381 l
196.155 758.381 l
198.279 757.881 l
200.28 757.631 l
202.779 757.631 l
204.279 757.381 l
206.154 757.131 l
207.904 757.006 l
210.404 756.881 l
211.904 756.506 l
214.029 756.256 l
215.779 756.256 l
217.779 756.381 l
220.529 756.256 l
222.279 756.006 l
225.154 756.131 l
227.779 755.756 l
230.029 755.631 l
231.404 754.881 l
233.154 755.006 l
236.779 755.256 l
238.279 754.506 l
240.904 754.006 l
246.654 754.006 l
250.029 754.256 l
250.779 753.631 l
252.404 753.131 l
254.154 752.256 l
256.779 752.506 l
258.654 752.381 l
260.654 752.381 l
262.154 752.006 l
264.404 751.006 l
S
[2 2 ]0 d
92.28 771.506 m
95.03 770.63 l
97.155 770.255 l
98.03 769.13 l
100.155 768.38 l
101.155 767.006 l
103.905 766.505 l
104.53 765.005 l
107.405 764.381 l
108.28 764.006 l
111.03 763.756 l
113.905 762.256 l
118.155 761.256 l
121.28 760.881 l
124.03 759.631 l
125.405 758.256 l
129.155 757.506 l
133.155 757.006 l
135.53 756.506 l
139.03 755.631 l
142.905 755.631 l
146.03 754.756 l
149.03 754.631 l
151.78 753.756 l
155.03 753.381 l
157.78 752.381 l
160.405 751.756 l
164.655 751.631 l
166.53 750.881 l
169.905 750.631 l
172.03 749.881 l
175.155 749.381 l
177.905 748.381 l
180.905 748.131 l
184.53 747.881 l
189.03 748.006 l
190.655 747.756 l
190.905 746.256 l
194.154 746.131 l
197.529 745.631 l
201.904 745.506 l
204.404 744.506 l
207.904 744.131 l
212.529 743.381 l
215.404 743.381 l
219.404 742.631 l
222.654 741.631 l
226.029 740.256 l
230.654 740.006 l
242.029 740.006 l
244.779 739.506 l
246.779 738.256 l
247.779 737.006 l
250.654 737.256 l
253.404 737.006 l
254.779 734.881 l
259.529 735.006 l
262.904 735.006 l
264.529 733.756 l
S
BT
/F3 1 Tf
7.97 0 0 7.97 58.28 606.557 Tm
0 g
/GS2 gs
[(Fig.)-327.1(1.)-331.2(\261)-332.2(Probability)-509.8(of)-515.2(outcome)-512.3(other)-510.3(than)-519.3(defaulting)-510.7(in)-510.3(three)-516.4(risk)]TJ
0 -1.067 TD
[(groups)-493.8(among)-500.9(tuberculosis)-487.5(patients)-501.7(diagnosed)-494.8(in)-496.1(1993\2611997)-493.2(in)-496.1(the)]TJ
0 -1.0599 TD
[(Netherlands)10.4(.)]TJ
5.4344 0 TD
0.4178 Tc
(----:)Tj
3.649 0 TD
0 Tc
[(asylum)-409.9(seekers;)-411.9(\261)-417.6(\261)-410.5(\261)-417.6(:)-420(other)-410.7(high-risk)-414.2(groups)]TJ
-9.0835 -1.0599 TD
[(including)-463.8(other)-460.5(recent)-463.5(immigrants,)-462.6(illegal)-469.4(immigra)10.2(nts,)-465.7(the)-471.7(homeless,)]TJ
0 -1.067 TD
[(prisoners)-326.6(and)-327(nationals)-328.8(from)-326.6(Eastern)-331.1(Europe;)-323.8(\320\320:)-326.2(all)-331.8(others.)]TJ
ET
[]0 d
/GS3 gs
254.779 277.367 m
246.154 280.617 l
237.654 282.367 l
228.904 273.617 l
220.279 278.367 l
211.28 293.992 l
202.78 291.867 l
194.405 295.117 l
185.78 296.992 l
176.78 304.992 l
168.28 307.867 l
159.53 307.992 l
151.03 304.992 l
142.28 307.742 l
124.655 307.742 l
116.155 304.742 l
107.655 307.492 l
90.155 307.492 l
86.78 193.992 m
86.78 321.742 l
86.655 303.492 m
84.53 303.492 l
86.78 321.492 m
84.53 321.492 l
86.78 285.242 m
84.53 285.242 l
86.78 266.992 m
84.53 266.992 l
86.655 248.742 m
84.53 248.742 l
86.655 230.742 m
84.53 230.742 l
86.655 212.242 m
84.53 212.242 l
86.78 194.117 m
84.53 194.117 l
86.78 194.117 m
260.029 194.117 l
190.655 194.117 m
190.655 192.117 l
259.779 194.117 m
259.779 192.117 l
225.029 194.117 m
225.029 192.117 l
155.905 194.117 m
155.905 192.117 l
122.78 194.117 m
122.78 192.117 l
86.78 194.117 m
86.78 192.117 l
259.796 194.117 m
259.796 321.742 l
259.654 209.117 m
261.779 209.117 l
259.779 194.117 m
261.779 194.117 l
259.654 223.492 m
261.779 223.492 l
259.779 237.617 m
261.779 237.617 l
259.779 251.742 m
261.779 251.742 l
259.654 265.742 m
261.779 265.742 l
259.654 279.867 m
261.779 279.867 l
259.779 294.242 m
261.779 294.242 l
259.654 308.492 m
261.779 308.492 l
259.654 321.492 m
261.779 321.492 l
S
BT
/F15 1 Tf
10 0 0 10 74.405 318.275 Tm
0 0 0 1 k
/GS4 gs
(35)Tj
0 -1.8017 TD
(30)Tj
0 -1.8267 TD
(25)Tj
T*
(20)Tj
0 -1.825 TD
(15)Tj
0 -1.7983 TD
(10)Tj
0.45 -1.8466 TD
(5)Tj
0 -1.8142 TD
(0)Tj
-0.15 -0.9267 TD
[(1993)-1786.8(1994)-1477.7(1995)-1649.3(1996)-1601(1997)-1660.2(1998)]TJ
18.5583 0.9425 TD
(0)Tj
0.0166 1.4658 TD
(5)Tj
-0.0525 1.4608 TD
(10)Tj
-0.0058 1.4058 TD
(15)Tj
0.055 1.4142 TD
(20)Tj
0.0033 1.3892 TD
(25)Tj
-0.0041 1.4217 TD
(30)Tj
-0.01 1.4358 TD
(35)Tj
0.0058 1.4267 TD
(40)Tj
0.0083 1.3 TD
(45)Tj
0 10 -10 0 285.529 195.742 Tm
[(Median treatment dur)10(ation  w)10(eeks)]TJ
4.25 21.725 TD
[(Def)30(ault  %)]TJ
10 0 0 10 164.53 170.493 Tm
[(Y)140(ear)]TJ
ET
0 0 0 0 k
/GS3 gs
88.333 307.54 m
88.333 308.506 89.116 309.29 90.083 309.29 c
91.049 309.29 91.833 308.506 91.833 307.54 c
91.833 306.573 91.049 305.79 90.083 305.79 c
89.116 305.79 88.333 306.573 88.333 307.54 c
b
0 0 0 1 k
88.382 268.04 3.5 -3.5 re
B
88.42 291.79 m
92.045 291.79 l
90.17 295.29 l
88.42 291.79 l
b
88.316 224.79 m
88.316 225.757 89.1 226.54 90.066 226.54 c
91.033 226.54 91.816 225.757 91.816 224.79 c
91.816 223.823 91.033 223.04 90.066 223.04 c
89.1 223.04 88.316 223.823 88.316 224.79 c
b
97.083 226.29 m
97.083 227.257 97.866 228.04 98.833 228.04 c
99.799 228.04 100.583 227.257 100.583 226.29 c
100.583 225.323 99.799 224.54 98.833 224.54 c
97.866 224.54 97.083 225.323 97.083 226.29 c
b
105.708 229.79 m
105.708 230.756 106.491 231.54 107.458 231.54 c
108.424 231.54 109.208 230.756 109.208 229.79 c
109.208 228.824 108.424 228.04 107.458 228.04 c
106.491 228.04 105.708 228.824 105.708 229.79 c
b
114.349 227.79 m
114.349 228.757 115.133 229.54 116.099 229.54 c
117.066 229.54 117.849 228.757 117.849 227.79 c
117.849 226.823 117.066 226.04 116.099 226.04 c
115.133 226.04 114.349 226.823 114.349 227.79 c
b
122.991 222.165 m
122.991 223.132 123.775 223.915 124.741 223.915 c
125.708 223.915 126.491 223.132 126.491 222.165 c
126.491 221.198 125.708 220.415 124.741 220.415 c
123.775 220.415 122.991 221.198 122.991 222.165 c
b
131.758 221.79 m
131.758 222.757 132.541 223.54 133.508 223.54 c
134.474 223.54 135.258 222.757 135.258 221.79 c
135.258 220.823 134.474 220.04 133.508 220.04 c
132.541 220.04 131.758 220.823 131.758 221.79 c
b
140.508 224.79 m
140.508 225.757 141.291 226.54 142.258 226.54 c
143.224 226.54 144.008 225.757 144.008 224.79 c
144.008 223.823 143.224 223.04 142.258 223.04 c
141.291 223.04 140.508 223.823 140.508 224.79 c
b
149.258 225.415 m
149.258 226.382 150.041 227.165 151.007 227.165 c
151.974 227.165 152.758 226.382 152.758 225.415 c
152.758 224.449 151.974 223.665 151.007 223.665 c
150.041 223.665 149.258 224.449 149.258 225.415 c
b
157.866 221.165 m
157.866 222.132 158.649 222.915 159.616 222.915 c
160.582 222.915 161.366 222.132 161.366 221.165 c
161.366 220.199 160.582 219.415 159.616 219.415 c
158.649 219.415 157.866 220.199 157.866 221.165 c
b
166.224 217.165 m
166.224 218.132 167.008 218.915 167.974 218.915 c
168.941 218.915 169.724 218.132 169.724 217.165 c
169.724 216.199 168.941 215.415 167.974 215.415 c
167.008 215.415 166.224 216.199 166.224 217.165 c
b
174.991 216.165 m
174.991 217.132 175.774 217.915 176.741 217.915 c
177.707 217.915 178.491 217.132 178.491 216.165 c
178.491 215.199 177.707 214.415 176.741 214.415 c
175.774 214.415 174.991 215.199 174.991 216.165 c
b
183.882 213.273 m
183.882 214.24 184.666 215.023 185.632 215.023 c
186.599 215.023 187.382 214.24 187.382 213.273 c
187.382 212.307 186.599 211.523 185.632 211.523 c
184.666 211.523 183.882 212.307 183.882 213.273 c
b
192.366 210.898 m
192.366 211.865 193.149 212.648 194.116 212.648 c
195.082 212.648 195.866 211.865 195.866 210.898 c
195.866 209.932 195.082 209.148 194.116 209.148 c
193.149 209.148 192.366 209.932 192.366 210.898 c
b
201.007 212.148 m
201.007 213.115 201.791 213.898 202.757 213.898 c
203.724 213.898 204.507 213.115 204.507 212.148 c
204.507 211.182 203.724 210.398 202.757 210.398 c
201.791 210.398 201.007 211.182 201.007 212.148 c
b
209.524 212.648 m
209.524 213.615 210.307 214.398 211.274 214.398 c
212.241 214.398 213.024 213.615 213.024 212.648 c
213.024 211.682 212.241 210.898 211.274 210.898 c
210.307 210.898 209.524 211.682 209.524 212.648 c
b
218.682 212.523 m
218.682 213.49 219.466 214.273 220.432 214.273 c
221.399 214.273 222.182 213.49 222.182 212.523 c
222.182 211.557 221.399 210.773 220.432 210.773 c
219.466 210.773 218.682 211.557 218.682 212.523 c
b
227.182 217.148 m
227.182 218.115 227.966 218.898 228.932 218.898 c
229.899 218.898 230.682 218.115 230.682 217.148 c
230.682 216.182 229.899 215.398 228.932 215.398 c
227.966 215.398 227.182 216.182 227.182 217.148 c
b
235.932 211.523 m
235.932 212.49 236.715 213.273 237.682 213.273 c
238.649 213.273 239.432 212.49 239.432 211.523 c
239.432 210.557 238.649 209.773 237.682 209.773 c
236.715 209.773 235.932 210.557 235.932 211.523 c
b
244.307 207.148 m
244.307 208.115 245.09 208.898 246.057 208.898 c
247.024 208.898 247.807 208.115 247.807 207.148 c
247.807 206.182 247.024 205.398 246.057 205.398 c
245.09 205.398 244.307 206.182 244.307 207.148 c
b
253.074 208.398 m
253.074 209.365 253.857 210.148 254.824 210.148 c
255.79 210.148 256.574 209.365 256.574 208.398 c
256.574 207.432 255.79 206.648 254.824 206.648 c
253.857 206.648 253.074 207.432 253.074 208.398 c
b
0 0 0 0 k
96.958 307.415 m
96.958 308.381 97.741 309.165 98.708 309.165 c
99.674 309.165 100.458 308.381 100.458 307.415 c
100.458 306.448 99.674 305.665 98.708 305.665 c
97.741 305.665 96.958 306.448 96.958 307.415 c
b
105.599 307.54 m
105.599 308.506 106.383 309.29 107.349 309.29 c
108.316 309.29 109.099 308.506 109.099 307.54 c
109.099 306.573 108.316 305.79 107.349 305.79 c
106.383 305.79 105.599 306.573 105.599 307.54 c
b
114.366 304.79 m
114.366 305.756 115.15 306.54 116.116 306.54 c
117.083 306.54 117.866 305.756 117.866 304.79 c
117.866 303.823 117.083 303.04 116.116 303.04 c
115.15 303.04 114.366 303.823 114.366 304.79 c
b
122.866 307.665 m
122.866 308.631 123.649 309.415 124.616 309.415 c
125.582 309.415 126.366 308.631 126.366 307.665 c
126.366 306.698 125.582 305.915 124.616 305.915 c
123.649 305.915 122.866 306.698 122.866 307.665 c
b
131.633 307.665 m
131.633 308.631 132.416 309.415 133.383 309.415 c
134.349 309.415 135.133 308.631 135.133 307.665 c
135.133 306.698 134.349 305.915 133.383 305.915 c
132.416 305.915 131.633 306.698 131.633 307.665 c
b
140.399 307.79 m
140.399 308.756 141.183 309.54 142.149 309.54 c
143.116 309.54 143.899 308.756 143.899 307.79 c
143.899 306.823 143.116 306.04 142.149 306.04 c
141.183 306.04 140.399 306.823 140.399 307.79 c
b
149.291 305.04 m
149.291 306.006 150.074 306.79 151.041 306.79 c
152.007 306.79 152.791 306.006 152.791 305.04 c
152.791 304.073 152.007 303.29 151.041 303.29 c
150.074 303.29 149.291 304.073 149.291 305.04 c
b
157.791 308.04 m
157.791 309.006 158.574 309.79 159.541 309.79 c
160.507 309.79 161.291 309.006 161.291 308.04 c
161.291 307.073 160.507 306.29 159.541 306.29 c
158.574 306.29 157.791 307.073 157.791 308.04 c
b
166.416 308.04 m
166.416 309.006 167.199 309.79 168.166 309.79 c
169.132 309.79 169.916 309.006 169.916 308.04 c
169.916 307.073 169.132 306.29 168.166 306.29 c
167.199 306.29 166.416 307.073 166.416 308.04 c
b
174.916 305.165 m
174.916 306.131 175.699 306.915 176.666 306.915 c
177.632 306.915 178.416 306.131 178.416 305.165 c
178.416 304.198 177.632 303.415 176.666 303.415 c
175.699 303.415 174.916 304.198 174.916 305.165 c
b
183.791 296.915 m
183.791 297.881 184.574 298.665 185.541 298.665 c
186.507 298.665 187.291 297.881 187.291 296.915 c
187.291 295.948 186.507 295.165 185.541 295.165 c
184.574 295.165 183.791 295.948 183.791 296.915 c
b
192.557 295.165 m
192.557 296.131 193.341 296.915 194.307 296.915 c
195.274 296.915 196.057 296.131 196.057 295.165 c
196.057 294.198 195.274 293.415 194.307 293.415 c
193.341 293.415 192.557 294.198 192.557 295.165 c
b
200.916 291.915 m
200.916 292.881 201.699 293.665 202.666 293.665 c
203.632 293.665 204.416 292.881 204.416 291.915 c
204.416 290.948 203.632 290.165 202.666 290.165 c
201.699 290.165 200.916 290.948 200.916 291.915 c
b
209.682 293.915 m
209.682 294.881 210.466 295.665 211.432 295.665 c
212.399 295.665 213.182 294.881 213.182 293.915 c
213.182 292.948 212.399 292.165 211.432 292.165 c
210.466 292.165 209.682 292.948 209.682 293.915 c
b
218.541 278.54 m
218.541 279.506 219.324 280.29 220.29 280.29 c
221.257 280.29 222.041 279.506 222.041 278.54 c
222.041 277.573 221.257 276.79 220.29 276.79 c
219.324 276.79 218.541 277.573 218.541 278.54 c
b
227.166 273.79 m
227.166 274.756 227.949 275.54 228.915 275.54 c
229.882 275.54 230.666 274.756 230.666 273.79 c
230.666 272.823 229.882 272.04 228.915 272.04 c
227.949 272.04 227.166 272.823 227.166 273.79 c
b
235.916 282.29 m
235.916 283.256 236.699 284.04 237.665 284.04 c
238.632 284.04 239.415 283.256 239.415 282.29 c
239.415 281.323 238.632 280.54 237.665 280.54 c
236.699 280.54 235.916 281.323 235.916 282.29 c
b
253.04 277.415 m
253.04 278.381 253.824 279.165 254.79 279.165 c
255.757 279.165 256.54 278.381 256.54 277.415 c
256.54 276.448 255.757 275.665 254.79 275.665 c
253.824 275.665 253.04 276.448 253.04 277.415 c
b
0 0 0 1 k
97.045 281.79 m
100.67 281.79 l
98.795 285.29 l
97.045 281.79 l
b
105.545 280.29 m
109.17 280.29 l
107.295 283.79 l
105.545 280.29 l
b
114.186 283.29 m
117.811 283.29 l
115.936 286.79 l
114.186 283.29 l
b
122.828 294.273 m
126.453 294.273 l
124.578 297.773 l
122.828 294.273 l
b
131.453 297.773 m
135.078 297.773 l
133.203 301.273 l
131.453 297.773 l
b
140.203 292.381 m
143.828 292.381 l
141.953 295.881 l
140.203 292.381 l
b
149.095 286.24 m
152.72 286.24 l
150.845 289.74 l
149.095 286.24 l
b
157.719 265.24 m
161.344 265.24 l
159.469 268.74 l
157.719 265.24 l
b
166.186 246.49 m
169.811 246.49 l
167.936 249.99 l
166.186 246.49 l
b
174.986 254.956 m
178.611 254.956 l
176.736 258.456 l
174.986 254.956 l
b
183.736 272.156 m
187.361 272.156 l
185.486 275.656 l
183.736 272.156 l
b
192.378 282.156 m
196.003 282.156 l
194.128 285.656 l
192.378 282.156 l
b
200.861 286.281 m
204.486 286.281 l
202.611 289.781 l
200.861 286.281 l
b
209.486 274.781 m
213.111 274.781 l
211.236 278.281 l
209.486 274.781 l
b
218.486 259.406 m
222.111 259.406 l
220.236 262.906 l
218.486 259.406 l
b
227.128 257.531 m
230.753 257.531 l
228.878 261.031 l
227.128 257.531 l
b
235.769 257.656 m
239.394 257.656 l
237.519 261.156 l
235.769 257.656 l
b
244.128 252.906 m
247.752 252.906 l
245.877 256.406 l
244.128 252.906 l
b
252.878 241.406 m
256.502 241.406 l
254.627 244.906 l
252.878 241.406 l
b
97.257 254.54 3.5 -3.5 re
B
105.632 243.29 3.5 -3.5 re
B
114.273 256.665 3.5 -3.5 re
B
122.898 264.79 3.5 -3.5 re
B
131.523 259.54 3.5 -3.5 re
B
140.398 252.29 3.5 -3.5 re
B
149.148 249.165 3.5 -3.5 re
B
157.773 252.79 3.5 -3.5 re
B
166.148 251.665 3.5 -3.5 re
B
174.773 244.165 3.5 -3.5 re
B
183.898 233.415 3.5 -3.5 re
B
192.398 233.04 3.5 -3.5 re
B
200.898 232.04 3.5 -3.5 re
B
209.648 225.79 3.5 -3.5 re
B
218.523 230.29 3.5 -3.5 re
B
227.148 228.79 3.5 -3.5 re
B
235.773 235.165 3.5 -3.5 re
B
244.398 239.165 3.5 -3.5 re
B
252.898 233.29 3.5 -3.5 re
B
254.779 231.117 m
246.029 237.492 l
237.404 233.117 l
229.029 226.492 l
220.155 228.742 l
211.53 223.867 l
202.905 229.992 l
194.28 231.242 l
185.78 231.492 l
176.655 242.367 l
168.03 249.992 l
159.53 251.117 l
150.905 247.242 l
142.155 250.617 l
133.53 257.742 l
124.78 263.242 l
115.905 254.867 l
107.405 241.242 l
99.03 252.867 l
90.53 266.117 l
90.155 224.617 m
98.905 226.367 l
107.53 229.867 l
116.155 227.742 l
124.905 221.992 l
133.53 221.992 l
142.155 224.742 l
151.155 225.367 l
159.78 221.117 l
168.155 217.117 l
176.78 216.117 l
185.53 213.492 l
194.03 210.992 l
202.78 212.117 l
211.28 212.867 l
220.155 212.492 l
228.779 217.117 l
237.654 211.367 l
246.279 206.992 l
254.779 208.242 l
254.904 242.867 m
246.029 254.617 l
237.529 259.242 l
229.154 259.242 l
220.53 260.992 l
211.53 276.492 l
202.78 287.742 l
194.155 283.492 l
185.405 273.367 l
176.78 256.242 l
168.28 247.617 l
159.53 266.992 l
151.03 287.617 l
142.28 293.867 l
133.28 299.617 l
124.655 295.992 l
116.155 285.117 l
107.53 281.867 l
99.03 283.242 l
90.155 293.242 l
S
0 0 0 0 k
244.29 280.79 m
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T*
[(fi)17.3(rs)18.4(t)-310.4(6)-313.7(mo)18.1(nt)18.9(hs)-304.3(of)-299(tr)17.3(ea)14.7(tm)15.7(en)20.8(t.)-305.1(T)12.2(h)0(e)-303.5(r)0(i)17.3(s)0(k)-304.3(o)0(f)-299(d)0(e)15.1(f)0(a)19.2(u)0(l)18.9(t)0(i)16.5(n)0(g)-303.1(a)0(m)17.7(o)0(n)15.5(g)]TJ
0 -1.0471 TD
[(ot)18.9(he)15.1(r)-230(h)0(i)18.9(g)0(h)15.5(-)0(r)18(i)0(s)17.7(k)-228.4(gr)13.9(ou)21.2(ps)14.4(,)-228(a)0(l)18.4(t)0(h)18.9(o)0(u)15.5(g)0(h)-217.8(s)0(o)14.4(m)0(e)17.7(w)0(h)17.3(a)0(t)-220.6(d)0(e)15.1(c)0(l)18.5(i)0(n)18.9(i)0(n)18.9(g)-234.1(ov)21.2(er)24.9(-)]TJ
0 -1.0528 TD
[(al)18.4(l,)-316.5(di)18.9(d)-319.4(n)0(o)15.5(t)-321.8(de)15.1(cr)19.2(ea)14.7(se)-310.4(ov)15.5(er)-310.8(th)13.2(e)-319.8(f)0(i)17.3(r)0(s)18.4(t)-321.8(6)-325.1(m)0(o)18.1(n)0(t)18.9(h)0(s)-315.7(o)0(f)-316.1(t)0(r)17.3(e)0(a)20.4(t)0(m)15.7(e)0(n)15.1(t)0(.)]TJ
0 -1.0471 TD
[(De)16.9(fa)19.2(ul)13.2(ti)16.5(ng)-399.9(wa)16.9(s)-411.7(r)0(e)19.2(c)0(o)15.1(g)0(n)21.2(i)0(z)12.8(e)0(d)-400.3(a)0(s)-401.5(a)-410.9(pr)13.9(ob)21.2(le)18.4(m)-413.6(a)0(m)17.7(o)0(n)15.5(g)-410.5(as)19.6(yl)13.2(um)]TJ
0 -1.0527 TD
[(se)19.6(ek)15.1(er)19.2(s)-428.7(i)0(n)-419.3(1)0(9)21.2(9)0(4)-416.9(a)0(n)15.1(d)-427.6(wa)16.9(s)-423.1(a)0(t)12.8(t)0(r)17.3(i)0(b)18.8(u)0(t)18.9(e)0(d)15.1(,)-421.5(in)-419.3(pa)15.1(rt)17.3(,)-427.2(t)0(o)-413.6(f)0(r)12.4(e)0(q)20.8(u)0(e)15.1(n)0(t)]TJ
0 -1.0471 TD
[(tr)17.3(an)15.1(sf)18.4(er)19.2(s)-349.1(w)0(i)14.9(t)0(h)-339.7(l)0(o)18.9(s)0(s)-345.3(o)0(f)-338.9(i)0(n)18.9(f)0(o)13.9(r)0(m)16.5(a)0(t)18.4(i)0(o)18.9(n)-347.9(be)15.1(tw)14.9(ee)20.4(n)-353.6(h)0(e)20.8(a)0(l)18.4(t)0(h)-339.7(a)0(u)15.1(t)0(h)18.9(o)0(r)25.3(-)]TJ
0 -1.0527 TD
[(it)16.5(ie)18.4(s)-423.1(o)0(f)-418.5(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nt)-413.6(re)13.5(gi)18.9(on)21.2(s.)-417.7(Im)16.5(pr)19.6(ov)15.5(ed)-417.3(co)20.8(-o)13.9(rd)19.6(in)18.9(at)18.5(io)13.2(n)-421.9(o)0(f)-412.8(t)0(h)13.2(e)]TJ
0 -1.0471 TD
[(fo)19.6(ll)16.5(ow)17.3(-u)13.9(p)-330.8(o)0(f)-321.8(a)0(s)14(y)0(l)18.9(u)0(m)-323.3(s)0(e)13.9(e)0(k)20.8(e)0(r)13.5(s)-332(wi)20.6(th)-328.3(tu)18.9(be)20.8(rc)13.5(ul)18.9(os)20(is)17.7(,)-336.1(f)0(a)19.2(c)0(i)18.5(l)0(i)16.5(t)0(a)18.4(t)0(e)12.8(d)]TJ
0 -1.0528 TD
[(by)-223.5(th)18.8(e)-228.8(r)0(e)13.5(c)0(r)19.2(u)0(i)18.9(t)0(m)15.7(e)0(n)15.1(t)-230.8(of)-219.4(a)-228.8(p)0(u)15.5(b)0(l)18.9(i)0(c)-226.2(h)0(e)20.8(a)0(l)18.4(t)0(h)-225.8(n)0(u)21.2(r)0(s)18.4(e)-234.5(at)-220.6(na)15.1(t)13.9(i)0(o)13.2(n)0(a)20.8(l)-230.8(le)18.4(ve)15.1(l)]TJ
0 -1.0471 TD
[(in)-316.9(19)21.2(95)15.5(,)-324.7(m)0(a)17.7(y)-325.1(ha)20.8(ve)-320.6(co)20.8(nt)18.9(ri)17.3(bu)15.5(te)18.4(d)-325.1(t)0(o)-316.9(d)0(e)20.8(c)0(r)13.5(e)0(a)20.4(s)0(e)13.9(d)-325.1(de)20.8(fa)19.2(ul)13.2(ti)16.5(ng)-314.5(in)]TJ
0 -1.0527 TD
[(th)18.9(is)-318.1(gr)19.6(ou)15.5(p.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(e)-490.6(s)0(t)17.7(u)0(d)21.2(y)-490.2(ai)18.4(me)12(d)-484.5(t)0(o)-481.9(i)0(n)18.9(c)0(l)12.8(u)0(d)21.2(e)-490.6(al)18.4(l)-492.5(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)13.9(s)-491.3(w)0(h)17.3(o)-490.2(st)17.7(ar)19.2(te)12.8(d)]TJ
-1.0015 -1.0528 TD
[(tu)18.9(be)15.1(rc)19.2(ul)18.9(os)14.4(is)-477.4(tr)17.3(ea)20.4(tm)15.7(en)15.1(t)-481.2(i)0(n)-481.9(t)13.9(he)-479.9(Ne)16.9(th)18.8(er)13.5(la)18.4(nd)21.2(s)-485.7(i)0(n)-476.2(t)0(h)13.2(e)-484.9(pe)20.8(ri)17.3(od)]TJ
0 -1.0471 TD
[(19)15.5(93)21.2(\2611)15.5(99)21.2(7.)-382.4(As)-382.2(cr)13.5(os)20(s-)18.4(ma)17.7(tc)12.8(hi)18.9(ng)-382.8(w)12.4(i)0(t)16.5(h)-393.4(ma)17.7(nd)15.5(at)18.4(or)19.6(y)-393.4(n)0(o)21.2(t)0(i)16.5(f)0(i)17.3(c)0(a)14.7(-)]TJ
0 -1.0527 TD
[(ti)16.5(on)21.2(s)-349.1(s)0(u)20(g)0(g)15.5(e)0(s)19.6(t)]TJ
/F8 1 Tf
5.5085 0 TD
0 Tw
(>)Tj
/F3 1 Tf
0.5406 0 TD
[(99)15.5(%)-344.6(c)0(o)15.1(m)0(p)18.1(l)0(e)18.4(t)0(e)12.8(n)0(e)20.8(s)0(s)18.9(,)-347.5(in)18.9(it)16.5(ia)18.4(l)-350.3(r)0(e)19.2(p)0(o)15.5(r)0(t)17.3(i)0(n)18.9(g)-347.9(is)-335.2(un)15.5(-)]TJ
-6.0491 -1.0471 TD
[(li)16.5(ke)20.8(ly)-362.4(to)-356.7(co)15.1(nt)18.9(ai)18.5(n)-370.7(s)0(t)17.7(r)0(o)19.6(n)0(g)-360(b)0(i)18.9(a)0(s)19.6(e)0(s)13.9(.)-364.6(Ho)17.3(we)16.9(ve)15.1(r)43.2(,)-370.3(in)18.9(fo)19.6(rm)16.5(at)12.8(io)18.9(n)-365(o)0(n)]TJ
0 -1.0528 TD
[(co)15.1(mp)18.1(le)18.4(ti)16.5(on)-303.1(of)-299(tr)17.3(ea)14.7(tm)15.7(en)20.8(t)-316.1(\()0(o)19.6(r)-309.7(de)15.1(at)18.4(h,)-302.7(de)20.8(fa)13.5(ul)18.9(t)-310.4(o)0(r)-304.7(t)0(r)17.3(a)0(n)20.8(s)0(f)12.8(e)0(r)-299.4(o)0(u)15.5(t)0(\))]TJ
0 -1.0471 TD
[(wa)16.9(s)-212.5(a)0(v)15.1(a)0(i)18.5(l)0(a)18.4(b)0(l)18.9(e)-211.7(on)15.5(ly)-203.1(fo)19.6(r)-212.9(9)0(5)15.5(%)-213.7(of)-202.3(pa)20.8(ti)16.5(en)15.1(ts)17.7(.)-210.9(A)0(s)-205.8(c)0(o)20.8(m)0(p)12.4(l)13.9(et)12.8(en)20.8(es)13.9(s)-212.5(o)0(f)]TJ
0 -1.0527 TD
[(re)19.2(po)15.5(rt)17.3(in)18.8(g)-382(w)0(a)16.9(s)-388.9(so)20(me)17.7(wh)17.3(at)-374.2(lo)13.2(w)12.4(e)0(r)-379.1(f)0(o)19.6(r)-372.2(gr)13.9(ou)21.2(ps)-372.6(in)-379.5(w)12.4(h)0(i)13.2(c)0(h)-371.8(d)0(e)15.1(f)0(-)]TJ
0 -1.0471 TD
[(au)15.1(lt)22.2(in)13.2(g)-302.4(w)12.4(as)-299(m)13.2(o)0(r)13.9(e)-302.8(co)20.8(mm)14.9(on)-297.4(\(s)18.4(uc)20.8(h)-302.4(a)0(s)-293.3(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-295.3(f)0(r)18(o)0(m)-294.9(E)0(a)16.7(s)0(t)17.7(e)0(r)13.5(n)]TJ
0 -1.0528 TD
[(Eu)17.1(ro)19.6(pe)15.1(\),)-327.1(de)15.1(fa)19.2(ul)18.9(ti)16.5(ng)-325.9(ra)13.5(te)18.4(s)-337.7(o)0(v)15.5(e)0(r)19.2(a)0(l)18.4(l)0(,)-327.9(a)0(n)15.1(d)0(,)-325.5(i)0(n)-328.3(p)0(a)15.1(r)0(t)17.3(i)0(c)18.4(u)0(l)18.9(a)0(r)-327.9(i)0(n)-328.3(t)0(h)13.2(e)]TJ
0 -1.0471 TD
[(hi)18.9(gh)15.5(-r)18(is)17.7(k)-148.7(g)0(r)19.6(o)0(u)15.5(p)0(s)20(,)-148.3(ma)17.7(y)-148.7(h)0(a)15.1(v)0(e)-138.5(b)0(e)15.1(e)0(n)-138.5(s)0(o)20(m)0(e)12(w)12.4(ha)15.1(t)-145.4(u)0(n)15.5(d)0(e)15.1(r)0(e)19.2(s)0(t)17.7(i)0(m)15.7(a)0(t)18.4(e)0(d)15.1(.)]TJ
1.0015 -1.0528 TD
[(Mo)13.6(st)-505.9(of)-509.6(th)13.2(e)-513.3(p)0(r)13.9(e)0(s)19.6(e)0(n)15.1(t)-515.3(an)15.1(al)18.4(ys)14.4(es)-509.6(in)18.9(cl)18.5(ud)15.5(ed)-508.4(pa)20.8(ti)16.5(en)15.1(ts)-511.6(w)12.4(h)0(o)]TJ
-1.0015 -1.0471 TD
[(co)15.1(nt)18.9(in)18.9(ue)15.1(d)-342.2(t)0(r)17.3(e)0(a)14.7(t)0(m)15.7(e)0(n)20.8(t)-344.6(el)18.5(se)13.9(wh)17.3(er)19.2(e)-348.3(\()0(l)17.3(o)0(c)20.8(a)0(t)12.8(i)13.9(on)-337.3(un)15.5(kn)21.2(ow)17.3(n\))-338.9(in)-334(th)13.2(e)]TJ
0 -1.0527 TD
[(gr)19.6(ou)15.5(p)-592.6(o)0(f)-583.6(d)0(e)20.8(f)0(a)13.5(u)0(l)18.9(t)0(e)18.4(r)0(s)18.4(.)-592.2(Al)14.9(th)18.9(ou)15.5(gh)-582(no)15.5(t)-589.3(a)0(l)18.4(l)-595(of)-583.6(th)18.9(e)-593(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)]TJ
0 -1.0471 TD
[(re)19.2(po)15.5(rt)17.3(ed)-337.7(as)-338.9(ha)15.1(vi)18.9(ng)-337.3(mo)12.4(ve)20.8(d)-347.9(a)0(w)16.9(a)0(y)-343.4(m)0(a)17.7(y)-347.9(ha)20.8(ve)-343.4(de)20.8(fa)13.5(ul)18.9(te)18.4(d,)-336.9(th)13.2(e)]TJ
0 -1.0527 TD
[(ri)17.3(sk)-355.5(of)-355.9(de)15.1(fa)19.2(ul)18.9(ti)16.5(ng)-354.3(is)-357.9(li)16.5(ke)20.8(ly)-356.7(to)-356.7(be)-354.7(hi)18.9(gh)-360(i)13.9(n)-365(th)13.2(is)-352.2(gr)14(ou)21.2(p)-365([)0(2)19.6(0].)]TJ
0 -1.0471 TD
[(Althoug)-8.3(h)-399.1(the)-397.7(level)-402(of)-401.5(defaultin)-10.7(g)-393.4(may)-404.2(have)-396.5(bee)-8.8(n)-393.4(some)-7.8(-)]TJ
0 -1.0528 TD
[(what)-482.1(overestimate)-12.5(d)-473.1(b)0(y)-479.5(this)-475.6(approac)-8.1(h,)-473.5(the)-477.4(incl)-8.2(usion)-479.7(or)]TJ
0 -1.0471 TD
[(exclus)-9(ion)-562.3(of)-566.5(this)-566.7(group)-563.1(made)-570.4(little)-568.9(difference)-562.7(in)-567.3(the)]TJ
0 -1.0528 TD
[(analys)-9(is)-335.2(of)-333.2(most)-339.8(risk)-338.3(facto)-8.6(rs.)]TJ
1.0015 -1.0471 TD
[(It)-238.8(is)-238.4(co)20.8(nc)15.1(lu)18.9(de)20.8(d)-245.5(t)0(h)13.2(a)0(t)-231.9(t)0(h)13.2(e)-245.9(ri)17.3(sk)-236(of)-236.4(de)20.8(fa)13.5(ul)18.9(ti)16.5(ng)-234.8(wa)16.9(s)-246.6(~)0(1)18.1(0)0(%)-237.2(a)0(n)15.1(d)]TJ
-1.0015 -1.0527 TD
[(ri)17.3(sk)-264.5(gr)19.6(ou)15.5(ps)-264.5(fo)19.6(r)-275.5(d)0(e)15.1(f)0(a)19.2(u)0(l)18.9(t)0(i)16.5(n)0(g)-263.3(c)0(a)14.7(n)-273.9(be)-263.7(re)19.2(co)15.1(gn)21.2(iz)12.8(ed)-263.7(at)-266.1(t)13.9(h)0(e)-269.4(s)0(t)17.7(a)0(r)19.2(t)-276.3(of)]TJ
T*
[(tr)17.3(ea)14.7(tm)21.4(en)15.1(t.)-145.8(De)16.9(fa)13.5(ul)18.9(ti)16.5(ng)-149.5(de)20.8(cr)13.5(ea)20.4(se)13.9(d)-154.4(o)0(v)15.5(e)0(r)-145.8(t)0(i)16.5(m)0(e)17.7(,)-159.7(pr)19.6(ob)15.5(ab)20.8(ly)81.4(,)-159.7(i)0(n)-146.2(p)0(a)15.1(r)0(t)17.3(,)]TJ
0 -1.0471 TD
[(du)15.5(e)-416.6(t)0(o)-413.6(s)0(h)20(o)0(r)13.9(t)13.9(e)0(n)15.1(i)0(n)18.9(g)-421.9(tr)17.3(ea)20.4(tm)15.7(en)15.1(t)-418.6(f)0(r)18(o)0(m)-414.4(9)0(\261)15.5(6)-416.2(mo)18.1(nt)13.2(hs)-406.8(an)15.1(d)-421.9(i)0(m)21.4(p)0(-)]TJ
0 -1.0527 TD
[(ro)19.6(ve)15.1(d)-393.4(f)0(o)19.6(l)0(l)16.5(o)0(w)17.3(-)0(u)19.6(p)-393.4(of)-384.4(as)19.6(yl)13.2(um)-380.3(se)13.9(ek)20.8(er)13.5(s.)-377.9(Ho)11.6(w)12.4(e)0(v)15.1(e)0(r)47.7(,)-387.3(ad)15.1(di)18.9(ti)16.5(on)15.5(al)]TJ
0 -1.0471 TD
[(me)17.7(as)14(ur)19.6(es)-190.9(ar)13.5(e)-200.3(n)0(e)20.8(e)0(d)15.1(e)0(d)-189.7(t)0(o)-191.7(r)0(e)13.5(d)0(u)21.2(c)0(e)-190.1(d)0(e)15.1(f)0(a)19.2(u)0(l)13.2(t)0(i)22.2(n)0(g)-195(a)0(m)17.7(o)0(n)15.5(g)-199.9(th)18.9(e)-200.3(h)0(o)15.5(m)0(e)17.7(-)]TJ
0 -1.0527 TD
[(le)18.4(ss)18.9(,)-324.7(r)0(e)13.5(c)0(e)20.4(n)0(t)-316.9(i)0(m)15.7(m)0(i)15.7(g)0(r)19.6(a)0(n)15.1(t)0(s)17.7(,)-319.1(il)16.5(le)18.4(ga)15.1(l)-321.8(i)0(m)15.7(m)0(i)15.7(g)0(r)13.9(a)0(n)20.8(t)0(s)-318.1(a)0(n)20.8(d)-325.1(pr)19.6(is)12(on)21.2(er)19.2(s.)]TJ
/F18 1 Tf
7.97 0 0 7.97 129.43 262.828 Tm
[(Acknowledgem)11.3(ents.)]TJ
/F3 1 Tf
9.0195 0 TD
[(The)-891.6(authors)-898.5(thank)-894.2(the)]TJ
-10.0153 -1.1239 TD
[(dedicated)-600.6(staf)12.8(f)-602.7(o)0(f)-600.6(the)-599.7(public)-595.8(health)-601.9(services)-596.8(in)]TJ
T*
[(the)-877.1(Netherlands)10.4(,)-881(without)-869.9(whose)-874.2(support)-878.2(this)]TJ
0 -1.131 TD
[(study)-427(would)-421.2(not)-422.9(have)-423.5(been)-423.5(possible.)-422.2(The)-422.2(authors)]TJ
0 -1.1239 TD
[(are)-397.3(grateful)-391.7(to)-389.4(C.S.B.)-389(Lambregts-v)11.1(an)-393.1(W)76.3(eezenbeek)]TJ
T*
[(for)-492(critically)-478.9(reviewing)-484.4(an)-485.6(earlier)-485.3(version)-486(of)-486.8(this)]TJ
T*
[(paper)55(.)]TJ
/F6 1 Tf
8.966 0 0 8.966 151.257 182.778 Tm
[(Referenc)8.7(es)]TJ
/F3 1 Tf
-10.3696 -2.2826 TD
[(1.)-1766.5(Styblo)-310.1(K.)-309.2(Epidemiology)-309.7(of)-309.8(tuberculosis.)-316.6(Selected)-308.2(papers)]TJ
2.5165 -1.1065 TD
[(24.)-318(The)-324.2(Hague,)-319.3(Royal)-320.5(Netherlands)-326.4(T)28.6(uberculosis)-324.5(Associ-)]TJ
0 -1.1128 TD
[(ation,)-333.7(1991.)]TJ
-2.5165 -1.1128 TD
[(2.)-1766.5(Royal)-206.6(Netherlands)-218.9(T)34.9(uberculosis)-217(Association.)-212(Index)-213.2(tuber-)]TJ
2.5165 -1.1065 TD
[(culosis)-446(1996.)-449.8(The)-450.7(Hague,)-445.8(Royal)-446.9(Netherlands)-452.8(T)28.6(ubercu-)]TJ
0 -1.1128 TD
[(losis)-333.4(Association,)-338.4(1997.)]TJ
25.4813 73.5671 TD
[(3.)-1766.5(Rieder)-491.4(HL,)-489.2(Zellweger)-487.8(JP)102.4(,)-489.8(Raviglione)-493.2(MC,)-487.8(Keizer)-489.8(ST)74.8(,)]TJ
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