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[(lica)-421.1(de)-414.5(Chile,)-409.5(Santiago,)]TJ
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T*
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(Fondecyt.)Tj
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T*
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T*
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(1)Tj
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[(\))-417.8(was)-423.2(a)]TJ
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T*
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(1)Tj
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T*
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T*
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T*
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T*
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[(volum)-9.3(e)-496.3(\()]TJ
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(V)Tj
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(T)Tj
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[(\))-497.4(a)0(t)-499.4(the)-500.2(expense)-502.8(of)-498.2(both)-500.5(the)-500.2(IR)71.8(V)-397.3(and)-497.8(the)]TJ
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[(expir)-8.2(atory)-457.8(reser)-9(ve)-451.5(volum)-9.3(e)-456.4([8,)-453.1(9].)-458.7(In)-452.7(contr)-8.2(ast,)-456.2(in)-459.2(flow-)]TJ
T*
[(limite)-12(d)-302.4(COPD)-310.8(pati)-8.2(ents,)]TJ
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(V)Tj
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(T)Tj
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[(incre)-8.6(ases)-307.8(only)-307(at)-305.9(the)-312.4(expense)]TJ
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T*
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(V)Tj
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(T)Tj
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(\()Tj
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(V)Tj
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7.97 0 0 7.97 421.342 319.805 Tm
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[(T,)-70.5(m)-70.6(a)-70.5(x)]TJ
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0 Tc
[(\))-372.2(achiev)-8.2(ed)-371.8(during)-372.7(exer-)]TJ
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[(cise)-434.2(shoul)-7.4(d)-427.6(depend)-432.2(on)-428.3(the)-426.2(magni)-9.7(tude)-426.9(of)-429.9(IC.)-429.3(Since)-433(the)]TJ
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6.974 0 0 6.974 148.876 264.246 Tm
0.0001 Tc
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0 Tc
[(et)-323(al.)]TJ
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[([15].)-325.3(Arteri)-11.2(al)-317.3(blood)-324.9(gas)]TJ
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[(Pr)27.3(ocedur)27.6(e)-336.9(and)-332.3(da)-7.2(ta)-334(analysis)]TJ
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(E)Tj
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(I)Tj
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[(\),)-293(ex)20.8(pi)18.9(ra)13.5(to)18.9(ry)-287.7(ti)16.5(me)-289.6(\()]TJ
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[(\),)-293(to)18.9(ta)18.4(l)-299.1(c)0(y)15.1(c)0(l)18.4(e)-297.1(du)21.2(ra)13.5(-)]TJ
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[(ti)16.5(on)-206.4(\()]TJ
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[(\),)-201.9(du)21.2(ty)-203.1(cy)15.1(cl)18.4(e)-211.7(\()]TJ
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(I)Tj
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[(to)23.1(t)]TJ
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(T)Tj
9.963 0 0 9.963 533.764 771.647 Tm
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(I)Tj
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[(\))-281.2(w)0(e)16.9(r)0(e)-276.7(o)0(b)21.2(t)0(a)18.4(i)0(n)18.9(e)0(d)-275.1(a)0(s)-270.6(a)0(v)15.1(e)0(r)19.2(a)0(g)15.1(e)-280(va)20.8(lu)13.2(es)-270.6(fr)18(om)-272.1(1-)13.9(mi)21.4(n)-285.3(r)0(e)19.2(c)0(o)15.1(r)0(d)19.6(s)-280.8(of)]TJ
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T*
[(FL\))-371.4(\(fig.)-373.2(1\).)-367.7(The)-365.3(FL)-369.1(portion)-370.2(of)-367.3(the)-369.3(tida)-8.2(l)-361.6(expir)-8.2(ation)-373.2(was)]TJ
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(T)Tj
9.963 0 0 9.963 493.172 667.049 Tm
[(\(FL,)-383.2(%)]TJ
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(T)Tj
9.963 0 0 9.963 533.253 667.049 Tm
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[(Exe)-7.2(r)32.2(cise)-337.5(test)]TJ
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[(\(E)15.5(R)-409.5(8)0(0)21.2(0)]TJ
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(1)Tj
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[(;)-407.2(E)12.2(ri)17.3(ch)-400.3(Ja)19.6(eg)15.1(er)47.7(,)-404.4(G)0(m)14.2(b)0(H)17.3(,)-404.4(Ho)17.3(es)13.9(cb)20.8(er)24.9(g,)-393.8(Ge)16.9(rm)16.5(an)15.1(y\))]TJ
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0.3389 Tc
[(;Q)338.9(u)356.2(i)338.9(n)357.7(t)338.9(o)357.8(n)338.9(,)13.4(W)450.8(A)338.9(,)]TJ
-16.6278 -1.0471 TD
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15.7742 0.1992 TD
(.)Tj
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[(mi)21.4(n)]TJ
7.472 0 0 6.641 484.271 551.055 Tm
(-1)Tj
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[(\(r)18(pm)18.1(\))-349.5(w)0(i)14.9(t)0(h)]TJ
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[(th)13.2(e)-280(e)0(x)15.1(t)13.9(er)13.5(na)20.8(l)-282(p)0(o)15.5(w)0(e)16.9(r)-281.2(in)18.8(cr)13.5(ea)20.4(se)14(d)-279.6(i)0(n)-271.4(1)0(-)13.9(m)0(i)15.7(n)-279.6(st)17.7(ep)20.8(s)-286.5(o)0(f)-270.6(5)0(\261)15.5(1)0(0)-269(w)0(a)16.9(t)0(t)16.5(s)]TJ
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0 -1.0527 TD
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0 -1.0471 TD
[(and)-344.1(were)-339.4(capabl)-8.2(e)-336.9(o)0(f)-338.9(quantifyi)-10.3(ng)-337.3(thei)-8.2(r)-332.4(level)-345.1(of)-338.9(dyspnoe)-6.9(a)]TJ
0 -1.0528 TD
[(or)-338.9(leg)-335.1(disco)-7.8(mfort.)-343(Oxygen)-339(saturati)-11.1(on,)-332(h)-6.5(eart)-337.9(rate)-337.9(and)-338.4(art-)]TJ
0 -1.0471 TD
[(erial)-318.3(pressure)-319.8(were)-311(conti)-9(nuously)-310.5(moni)-8.6(tored)-315.5(with)-313.3(a)-308.5(Dina-)]TJ
0 -1.0528 TD
(map)Tj
7.472 0 0 6.641 327.912 477.808 Tm
0.0001 Tc
(TM)Tj
9.963 0 0 9.963 339.024 473.386 Tm
0 Tc
[(Plus)-159.5(vital)-159.3(signs)-156.5(monitor)-162.8(\(Critikon,)-164.6(T)63.4(ampa,)-155.3(FL\))-7.2(.)-154(The)]TJ
-2.9818 -1.0471 TD
[(maxi)-9(mal)-463.5(mecha)-8.2(nical)-464.6(powe)-7.4(r)-463.3(output)-464.6(and)-463.6(oxygen)-465.9(uptake)]TJ
0 -1.0527 TD
[(wer)-8.2(e)-228.8(deter)-8.6(mined.)-232.1(The)-234.4(predicted)-236.4(norm)-7.8(al)-231.9(values)-230.9(for)]TJ
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19.9454 0 TD
(W)Tj
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(R)Tj
7.97 0 0 7.97 522.935 452.466 Tm
0.0001 Tc
(max)Tj
9.963 0 0 9.963 309.316 442.035 Tm
0 Tc
(and)Tj
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(V)Tj
/F8 1 Tf
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(')Tj
/F3 1 Tf
7.97 0 0 7.97 335.225 442.035 Tm
(O)Tj
7.472 0 0 6.641 340.951 440.39 Tm
(2)Tj
7.97 0 0 7.97 344.693 442.035 Tm
(,max)Tj
9.963 0 0 9.963 363.572 442.035 Tm
[(were)-339.4(those)-337.8(of)-333.2(J)]TJ
6.974 0 0 6.974 425.594 442.035 Tm
0.0001 Tc
(ONES)Tj
9.963 0 0 9.963 447.023 442.035 Tm
0 Tc
([17].)Tj
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-13.8223 -3.6875 TD
[(Stat)-7.8(istical)-340.8(analys)-8.6(is)]TJ
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6.974 0 0 6.974 446.513 384.378 Tm
[(SE)17.9(M)]TJ
9.963 0 0 9.963 460.573 384.378 Tm
[(.)-358.9(C)11.6(om)12.4(pa)20.8(ri)17.3(so)14.3(ns)-349.8(be)20.8(t-)]TJ
-15.1824 -1.0527 TD
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[(ana)-8.8(lysis)-432.1(was)-434.6(carri)-10.2(ed)-428.7(out)-431.5(using)]TJ
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6.974 0 0 6.974 377.121 431.093 Tm
0.0001 Tc
[(SE)18(M)]TJ
9.963 0 0 9.963 391.181 431.093 Tm
0.2072 Tc
[(\)v)207.2(a)228(l)207.2(u)220.4(e)207.2(s)10.6(o)207.2(f)]TJ
/F4 1 Tf
4.2395 0 TD
0 Tc
(W)Tj
/F3 1 Tf
0.8138 0 TD
(R)Tj
7.97 0 0 7.97 448.101 431.093 Tm
0.0001 Tc
[(ma)26.3(x)]TJ
9.963 0 0 9.963 463.578 431.093 Tm
0 Tc
[(an)15.1(d)]TJ
/F4 1 Tf
1.6275 0 TD
(V)Tj
/F8 1 Tf
0.5918 0 TD
(')Tj
/F3 1 Tf
7.97 0 0 7.97 487.786 431.093 Tm
(O)Tj
7.472 0 0 6.641 493.455 429.449 Tm
(2)Tj
7.97 0 0 7.97 497.083 431.093 Tm
-0.0172 Tc
[(,m)-17.3(ax)]TJ
9.963 0 0 9.963 514.488 431.093 Tm
0 Tc
[(of)-196.6(th)18.9(e)]TJ
-20.5941 -1.0584 TD
[(no)15.5(n-)19.6(FL)-408.9(an)15.1(d)-410.5(F)0(L)-408.9(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-403.4(a)0(r)13.5(e)-416.6(gi)18.9(ve)20.8(n)-416.2(i)0(n)-407.9(t)0(a)18.4(b)0(l)18.8(e)-416.6(2.)-416.6(In)-429.9(all)-422.9(FL)]TJ
0 -1.0641 TD
[(pati)-8.2(ents)]TJ
/F4 1 Tf
3.3916 0 TD
(V)Tj
/F8 1 Tf
0.6032 0 TD
(')Tj
/F3 1 Tf
7.97 0 0 7.97 351.269 409.946 Tm
(O)Tj
7.472 0 0 6.641 356.995 408.302 Tm
(2)Tj
7.97 0 0 7.97 360.737 409.946 Tm
(,max)Tj
9.963 0 0 9.963 379.389 409.946 Tm
(was)Tj
/F9 1 Tf
1.8494 0 TD
(<)Tj
/F3 1 Tf
0.5577 0 TD
[(80%)-311.9(pred)-312.3(normal,)-314.1(while)-314.5(this)-316.3(was)]TJ
-9.4406 -1.0584 TD
[(not)-340.4(the)-335.1(case)-335.5(for)-341.2(8)-330.8(\(35%\))-339.4(of)-338.9(the)-335.1(23)-337.3(non-FL)-339.6(subjects.)]TJ
1.0015 -1.0527 TD
[(Ac)11.2(co)20.8(rd)19.6(in)13.2(g)-211.3(t)0(o)-208.8(t)0(h)18.9(e)-217.4(li)16.5(ne)20.8(ar)-208.4(re)19.2(gr)14(es)19.6(si)17.7(on)-206.4(an)15.1(al)18.5(ys)20(is)17.7(,)-216.6(t)0(h)18.8(e)-217.4(st)17.7(ro)19.6(ng)15.5(es)19.6(t)]TJ
-1.0015 -1.0584 TD
[(co)15.1(rr)18(el)18.4(at)12.8(io)18.9(ns)-446.6(of)]TJ
/F4 1 Tf
6.2881 0 TD
(W)Tj
/F3 1 Tf
0.8137 0 TD
(R)Tj
7.97 0 0 7.97 386.589 378.368 Tm
0.0001 Tc
[(ma)19.2(x)]TJ
9.963 0 0 9.963 404.617 378.368 Tm
0 Tc
[(an)20.8(d)]TJ
/F4 1 Tf
1.8722 0 TD
(V)Tj
/F8 1 Tf
0.5975 0 TD
(')Tj
/F3 1 Tf
7.97 0 0 7.97 431.32 378.368 Tm
(O)Tj
7.472 0 0 6.641 436.932 376.724 Tm
(2)Tj
7.97 0 0 7.97 440.561 378.368 Tm
[(,m)17(ax)]TJ
9.963 0 0 9.963 460.46 378.368 Tm
[(to)-447.8(th)13.2(e)-456.4(i)0(n)18.9(d)0(e)15.1(p)0(e)20.8(n)0(d)15.5(e)0(n)20.8(t)]TJ
-15.171 -1.0641 TD
[(va)15.1(ri)17.3(ab)15.1(l)13.9(e)0(s)-469.7(u)0(s)20(e)0(d)-468.6(w)12.4(er)13.5(e)-473.5(w)0(i)14.9(t)0(h)-464.8(I)0(C)-463.1(a)0(n)15.1(d)-473.1(FE)17.9(V)]TJ
7.97 0 0 7.97 468.737 367.767 Tm
(1)Tj
9.963 0 0 9.963 472.649 367.767 Tm
[(/F)19.6(VC)12.6(.)-472.7(F)11.4(ig)18.9(ur)14(e)-473.5(3)]TJ
-16.3945 -1.0584 TD
[(dep)-8.4(ict)-252.1(the)-255.5(relationsh)-12.7(ips)-250.6(of)]TJ
/F4 1 Tf
10.5218 0 TD
(V)Tj
/F8 1 Tf
0.6032 0 TD
(')Tj
/F3 1 Tf
7.97 0 0 7.97 422.362 357.222 Tm
(O)Tj
7.472 0 0 6.641 428.088 355.578 Tm
(2)Tj
7.97 0 0 7.97 431.83 357.222 Tm
(,max)Tj
9.963 0 0 9.963 449.858 357.222 Tm
[(to)-254.3(IC)-252.5(and)-253.1(FEV)]TJ
7.97 0 0 7.97 507.968 357.222 Tm
(1)Tj
9.963 0 0 9.963 511.937 357.222 Tm
[(/FV)-7.8(C,)]TJ
-20.338 -1.0641 TD
[(all)-559.4(varia)-8.6(bles)-559(being)-558.6(expres)-8.2(sed)-555.9(as)-555.1(percent)-562.5(of)-560.8(predicted)]TJ
0 -1.0584 TD
[(norm)-7.8(al.)-442.9(The)-450.7(latter)-446.6(varia)-8.6(bles)-445.2(wer)-8.2(e)-439.3(selec)-8.6(ted)-448.9(by)-439.7(stepwi)-9.2(se)]TJ
0 -1.0641 TD
[(regres)-9.8(sion)-291.1(analysis)-292.9(as)-287.7(the)-283.9(only)-290(signifi)-9.6(cant)-290.8(contribut)-10.3(ors)-283.9(to)]TJ
/F4 1 Tf
0 -1.0584 TD
(W)Tj
/F3 1 Tf
0.8251 0 TD
(R)Tj
7.97 0 0 7.97 324.227 314.929 Tm
0.0001 Tc
(max)Tj
9.963 0 0 9.963 341.121 314.929 Tm
0 Tc
(and)Tj
/F4 1 Tf
1.7755 0 TD
(V)Tj
/F8 1 Tf
0.6032 0 TD
(')Tj
/F3 1 Tf
7.97 0 0 7.97 367.03 314.929 Tm
(O)Tj
7.472 0 0 6.641 372.699 313.285 Tm
(2)Tj
7.97 0 0 7.97 376.441 314.929 Tm
(,max)Tj
9.963 0 0 9.963 392.031 314.929 Tm
[(.)-336.1(The)-336.9(predi)-8.2(ctive)-339.4(equation)-11.7(s)-332(based)-341.6(on)]TJ
-8.3025 -1.0641 TD
[(these)-343.9(variables)-340(are,)-340.8(respec)-8.6(tively:)]TJ
/F10 1 Tf
1.5421 -1.4568 TD
(W)Tj
/F11 1 Tf
0.9958 0 TD
(R)Tj
6.974 0 0 6.974 342.255 290.041 Tm
0.0001 Tc
(max)Tj
/F12 1 Tf
1.9023 0 TD
0.0755 Tc
(\210\377)Tj
/F11 1 Tf
9.963 0 0 9.963 367.257 289.814 Tm
0 Tc
(7)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
(2)Tj
/F12 1 Tf
6.974 0 0 6.974 379.956 290.041 Tm
(\207)Tj
/F11 1 Tf
9.963 0 0 9.963 385.852 289.814 Tm
(0)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
(43IC)Tj
/F12 1 Tf
6.974 0 0 6.974 414.538 290.041 Tm
(\207)Tj
/F11 1 Tf
9.963 0 0 9.963 420.435 289.814 Tm
(0)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2732 0 TD
(37FEV)Tj
6.974 0 0 6.974 458.362 290.041 Tm
(1)Tj
/F13 1 Tf
9.963 0 0 9.963 462.387 289.814 Tm
(=)Tj
/F11 1 Tf
0.5008 0 TD
(FVC)Tj
/F8 1 Tf
6.974 0 0 6.974 488.239 290.891 Tm
(+)Tj
/F11 1 Tf
9.963 0 0 9.963 495.723 289.814 Tm
(9)Tj
/F13 1 Tf
0.5065 0 TD
(:)Tj
/F11 1 Tf
0.2675 0 TD
(6)Tj
/F12 1 Tf
2.0429 0 TD
(\205)Tj
/F14 1 Tf
0.387 0 TD
(1)Tj
/F12 1 Tf
0.5008 0 TD
(\206)Tj
/F10 1 Tf
-21.2087 -1.9632 TD
(V)Tj
/F12 1 Tf
6.974 0 0 6.974 328.479 274.394 Tm
(0)Tj
/F11 1 Tf
0.3496 -0.5609 TD
(O)Tj
4.981 0 0 4.981 336.302 269.405 Tm
(2)Tj
/F13 1 Tf
6.974 0 0 6.974 339.761 270.482 Tm
(;)Tj
/F11 1 Tf
0.2764 0 TD
0.0001 Tc
(max)Tj
/F12 1 Tf
1.821 0 TD
(\210\377)Tj
/F11 1 Tf
9.963 0 0 9.963 365.669 270.255 Tm
0 Tc
(6)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
(5)Tj
/F12 1 Tf
6.974 0 0 6.974 378.368 270.482 Tm
(\207)Tj
/F11 1 Tf
9.963 0 0 9.963 384.264 270.255 Tm
(0)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2675 0 TD
(48IC)Tj
/F12 1 Tf
6.974 0 0 6.974 412.951 270.482 Tm
(\207)Tj
/F11 1 Tf
9.963 0 0 9.963 418.847 270.255 Tm
(0)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2675 0 TD
(57FEV)Tj
6.974 0 0 6.974 456.775 270.482 Tm
(1)Tj
/F13 1 Tf
9.963 0 0 9.963 460.743 270.255 Tm
(=)Tj
/F11 1 Tf
0.5008 0 TD
(FVC)Tj
/F8 1 Tf
6.974 0 0 6.974 486.652 271.332 Tm
(+)Tj
/F11 1 Tf
9.963 0 0 9.963 494.135 270.255 Tm
(10)Tj
/F13 1 Tf
1.0015 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
(1)Tj
/F12 1 Tf
1.7015 0 TD
(\205)Tj
/F14 1 Tf
0.387 0 TD
(2)Tj
/F12 1 Tf
0.5008 0 TD
(\206)Tj
/F3 1 Tf
-22.4151 -1.508 TD
[(wher)-9(e)-302.8(all)-303.4(variables)-311.5(are)-300.6(expres)-8.2(sed)-305.5(as)-299(%)-304.7(pred)-306.7(normal.)-308.4(The)]TJ
0 -1.0641 TD
[(values)-464.2(of)-452.7(the)-454.6(correl)-11(ation)-458.5(coeff)9.3(icie)-8.6(nts)-455.4(\(r\))-456.6(for)-455(these)-457.7(reg-)]TJ
0 -1.0584 TD
[(ressi)-10.6(ons)-333.5(wer)-8.2(e)-331.2(0.79)-338.4(and)-332.8(0.85)-8.4(,)-330.4(respec)-8.6(tively)56.2(.)]TJ
1.0015 -1.0527 TD
[(Th)17.1(e)-206(a)0(b)15.1(o)0(v)21.2(e)-206(an)15.1(al)18.4(ys)20(is)-198.6(wa)16.9(s)-201.1(p)0(e)15.1(r)0(f)18(o)0(r)13.9(m)0(e)17.7(d)-205.6(se)19.6(pa)15.1(ra)19.2(te)18.4(ly)-197.4(fo)19.6(r)-207.2(F)11.4(L)-204.1(a)0(n)15.1(d)]TJ
-1.0015 -1.0584 TD
[(no)15.5(n-)19.6(FL)-243.9(pa)20.8(ti)16.5(en)15.1(ts)17.7(.)-245.1(F)0(o)16.3(r)-252.7(F)11.4(L)-249.6(pa)15.1(ti)16.5(en)20.8(ts)-244.1(on)21.2(ly)-242.9(IC)-241.1(wa)16.9(s)-252.3(s)0(e)19.6(l)0(e)18.4(c)0(t)18.4(e)0(d)-240.9(a)0(s)-242.1(a)]TJ
0 -1.0641 TD
[(si)17.7(gn)15.5(if)17.3(ic)18.4(an)15.1(t)-259.2(c)0(o)20.8(n)0(t)13.2(r)0(i)17.3(b)0(u)21.2(t)0(o)18.9(r)-264.1(by)-246.2(th)13.2(e)-257.2(s)0(t)17.7(e)0(p)15.1(w)12.4(is)12(e)-257.2(r)0(e)19.2(g)0(r)14(e)0(s)19.6(s)0(i)17.7(o)0(n)-251.9(a)0(n)20.8(a)0(l)12.8(y)0(s)20(i)0(s)17.7(,)]TJ
0 -1.0584 TD
[(wh)17.3(il)16.5(e)-365.4(f)0(o)19.6(r)-360.9(no)15.5(n-)19.6(FL)-352(pa)15.1(ti)16.5(en)20.8(ts)-352.2(on)15.5(ly)-351(FE)17.9(V)]TJ
7.97 0 0 7.97 455.074 191.905 Tm
(1)Tj
9.963 0 0 9.963 458.986 191.905 Tm
[(/F)19.6(VC)-351.6(wa)11.2(s)-360.5(s)0(e)19.6(l)0(e)18.4(c)0(t)18.5(e)0(d)15.1(.)]TJ
-15.0231 -1.0641 TD
[(Th)17.1(e)-325.5(e)0(q)15.1(u)0(a)20.8(t)0(i)16.5(o)0(n)15.5(s)-320.6(fo)13.9(r)-321(F)0(L)-317.8(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-312.4(w)0(e)16.9(r)0(e)13.5(:)]TJ
/F10 1 Tf
5.7361 -1.4568 TD
(W)Tj
/F11 1 Tf
0.9902 0 TD
(R)Tj
6.974 0 0 6.974 384.038 166.961 Tm
-0.0172 Tc
[(ma)-17.2(x)]TJ
/F12 1 Tf
1.8698 0 TD
0.0673 Tc
(\210\377)Tj
/F11 1 Tf
9.963 0 0 9.963 408.813 166.79 Tm
0 Tc
(14)Tj
/F13 1 Tf
0.9902 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
(7)Tj
/F12 1 Tf
6.974 0 0 6.974 426.387 166.961 Tm
(\207)Tj
/F11 1 Tf
9.963 0 0 9.963 432.283 166.79 Tm
(0)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
0.3308 Tc
[(3I)330.8(C)]TJ
/F8 1 Tf
6.974 0 0 6.974 459.212 167.868 Tm
0 Tc
(+)Tj
/F11 1 Tf
9.963 0 0 9.963 466.696 166.79 Tm
(8)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
(3)Tj
/F12 1 Tf
4.9565 0 TD
(\205)Tj
/F14 1 Tf
0.387 0 TD
(3)Tj
/F12 1 Tf
0.5008 0 TD
(\206)Tj
/F10 1 Tf
-16.3603 -1.9632 TD
(V)Tj
/F12 1 Tf
6.974 0 0 6.974 376.838 151.37 Tm
(0)Tj
/F11 1 Tf
0.3414 -0.5609 TD
(O)Tj
4.981 0 0 4.981 384.605 146.381 Tm
(2)Tj
/F13 1 Tf
6.974 0 0 6.974 388.12 147.458 Tm
(;)Tj
/F11 1 Tf
0.2683 0 TD
0.0001 Tc
[(ma)21.5(x)]TJ
/F12 1 Tf
1.7966 0 TD
0 Tc
(\210)Tj
/F11 1 Tf
9.963 0 0 9.963 408.416 147.231 Tm
(20)Tj
/F12 1 Tf
6.974 0 0 6.974 418.28 147.458 Tm
(\207)Tj
/F11 1 Tf
9.963 0 0 9.963 424.176 147.231 Tm
(0)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2732 0 TD
[(44)-325.9(IC)]TJ
/F8 1 Tf
6.974 0 0 6.974 455.981 148.309 Tm
(+)Tj
/F11 1 Tf
9.963 0 0 9.963 463.464 147.231 Tm
(7)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2732 0 TD
(6)Tj
/F12 1 Tf
5.2808 0 TD
(\205)Tj
/F14 1 Tf
0.387 0 TD
(4)Tj
/F12 1 Tf
0.5008 0 TD
(\206)Tj
/F3 1 Tf
-21.4135 -1.36 TD
[(Th)17.1(e)-308.5(v)0(a)15.1(l)0(u)18.9(e)0(s)-299(o)0(f)-293.3(t)0(h)18.9(e)-308.5(co)15.1(rr)18(el)18.4(at)18.4(io)13.2(n)-302.4(c)0(o)15.1(e)0(f)30.6(f)0(i)17.3(c)0(i)18.4(e)0(n)15.1(t)0(s)-295.3(f)0(o)14(r)-304(th)13.2(es)19.6(e)-308.5(r)0(e)19.2(g)0(-)]TJ
-1.0015 -1.0641 TD
[(re)13.5(ss)18.8(io)18.8(ns)-361.2(we)16.9(re)-362(0.)21.6(48)-360(an)15.1(d)-370.7(0)0(.)21.6(6)0(3)15.5(,)-364.6(re)13.5(sp)20(ec)14.7(ti)16.5(ve)20.8(ly)81.4(.)-370.3(T)0(h)17.1(e)-371.1(eq)20.8(ua)15.1(ti)16.5(on)21.2(s)]TJ
0 -1.0584 TD
[(fo)13.9(r)-321(n)0(o)15.5(n)0(-)19.6(F)0(L)-317.8(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-312.4(w)0(e)11.2(r)0(e)19.2(:)]TJ
ET
1 i 
58.28 386.305 227.168 -0.51 re
f
58.28 369.864 227.168 -0.51 re
f
58.28 173.594 227.168 -0.51 re
f
BT
/F2 1 Tf
8.966 0 0 8.966 58.28 419.017 Tm
[(Table)-331.9(1.)-336.7(\261)-333.2(Anthropometric,)-713.6(pulmonary,)-708.5(and)-708.7(respiratory)]TJ
0 -1.0559 TD
[(muscle)-411(data)-408.7(at)-412.6(rest)-407.9(of)-412.6(23)-407.2(non-flow)-415(limited)-409.5(\(non-FL\))-415.2(and)]TJ
T*
[(29)-217.5(flow-limited)-223.2(\(FL\))-222.9(chronic)-219.9(obstructive)-218.2(pulmonary)-224.5(disease)]TJ
0 -1.0496 TD
(patients)Tj
/F3 1 Tf
12.355 -1.7135 TD
[(Non-FL)-2880.2(FL)-2460.7(p-value)]TJ
-12.355 -1.998 TD
[(Subjects)-335.1(n)-9268.9(2)0(3)-4058.3(2)0(9)]TJ
0 -1.0559 TD
[(Age)-336.7(yr)-9870(67\2132)-3017.3(65\2131)]TJ
6.276 0 0 6.276 265.323 347.924 Tm
0.0001 Tc
(NS)Tj
8.966 0 0 8.966 58.28 338.457 Tm
0 Tc
[(Sex)-332(M:F)-9541.4(17:6)-3288.3(26:3)]TJ
6.276 0 0 6.276 265.323 338.457 Tm
0.0001 Tc
(NS)Tj
8.966 0 0 8.966 58.28 328.989 Tm
0 Tc
[(Smoking)-334.4(history)59.9(,)-331.7(pack-yrs)-2085.1(48\2134)-3017.3(54\2134)]TJ
6.276 0 0 6.276 265.323 328.989 Tm
0.0001 Tc
(NS)Tj
8.966 0 0 8.966 58.28 319.521 Tm
0 Tc
[(W)70.8(eight)-330.8(kg)-8509.6(65\2132)-3017.3(67\2132)]TJ
6.276 0 0 6.276 265.323 319.521 Tm
0.0001 Tc
(NS)Tj
8.966 0 0 8.966 58.28 310.053 Tm
0 Tc
[(Height)-333.6(cm)-7948.6(161\2132)-2517.2(166\2131)]TJ
6.276 0 0 6.276 265.323 310.053 Tm
0.0001 Tc
(NS)Tj
8.966 0 0 8.966 58.28 300.586 Tm
0 Tc
[(Body)-331.5(Mass)-335.9(Index,)-336.2(kg)]TJ
/F10 1 Tf
8.7699 0.2276 TD
(.)Tj
/F3 1 Tf
0.2719 -0.2276 TD
(m)Tj
6.725 0 0 5.977 146.268 304.611 Tm
(-2)Tj
8.966 0 0 8.966 172.006 300.586 Tm
[(25\2130.7)-2267.2(24\2130.9)]TJ
6.276 0 0 6.276 265.323 300.586 Tm
0.0001 Tc
(NS)Tj
/F4 1 Tf
8.966 0 0 8.966 58.28 291.118 Tm
0 Tc
(P)Tj
/F3 1 Tf
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7.472 0 0 6.641 465.789 738.538 Tm
(2)Tj
9.963 0 0 9.963 469.531 740.182 Tm
[(.)-484.1(The)-490.5(predi)-8.2(ctive)]TJ
-16.0815 -1.0528 TD
[(equ)-8.4(ation)-333.3(b)-6.5(ased)-335.1(on)-337.3(these)-338.3(variables)-340(is:)]TJ
/F10 1 Tf
1.0072 -1.4511 TD
(P)Tj
/F11 1 Tf
6.974 0 0 6.974 325.984 715.408 Tm
(a)Tj
/F13 1 Tf
0.504 0 TD
(;)Tj
/F11 1 Tf
0.2683 0 TD
0.0001 Tc
(CO)Tj
4.981 0 0 4.981 341.801 714.387 Tm
0 Tc
(2)Tj
/F12 1 Tf
9.963 0 0 9.963 348.038 715.238 Tm
(\210)Tj
/F11 1 Tf
1.0471 0 TD
(7)Tj
/F13 1 Tf
0.5065 0 TD
(:)Tj
/F11 1 Tf
0.2675 0 TD
(9)Tj
/F12 1 Tf
6.974 0 0 6.974 371.168 716.315 Tm
(\377)Tj
/F11 1 Tf
9.963 0 0 9.963 377.064 715.238 Tm
(0)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
[(015)-332.3(FV)-8.8(C)]TJ
/F12 1 Tf
6.974 0 0 6.974 423.949 716.315 Tm
(\377)Tj
/F11 1 Tf
9.963 0 0 9.963 429.846 715.238 Tm
(0)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
[(015)-332.3(IC)]TJ
/F8 1 Tf
6.974 0 0 6.974 466.866 716.315 Tm
(+)Tj
/F11 1 Tf
9.963 0 0 9.963 474.349 715.238 Tm
(0)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2675 0 TD
(7)Tj
/F12 1 Tf
0.8365 0 TD
(\205)Tj
/F11 1 Tf
6.974 0 0 6.974 494.192 715.408 Tm
0.0001 Tc
(SEM)Tj
/F12 1 Tf
9.963 0 0 9.963 509.953 715.238 Tm
1.0035 Tc
(\206\205)Tj
/F14 1 Tf
1.7755 0 TD
0 Tc
(7)Tj
/F12 1 Tf
0.5008 0 TD
(\206)Tj
/F3 1 Tf
-22.4151 -1.508 TD
[(wher)-9(e)]TJ
/F4 1 Tf
2.6802 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 342.028 700.214 Tm
(a,CO)Tj
7.472 0 0 6.641 358.526 698.57 Tm
(2)Tj
9.963 0 0 9.963 364.819 700.214 Tm
[(is)-261.2(in)-254.3(kP)-6.4(a,)-257.6(and)-258.8(FVC)-260.5(and)-258.8(IC)-258.2(are)-260.8(expres)-8.2(sed)-260(as)]TJ
-5.571 -1.0528 TD
[(%)-344.6(pred.)-341.2(The)-342.6(correl)-11(ation)-344.7(coefficient)-339(of)-344.6(this)-344.7(equation)-347.4(was)]TJ
T*
[(0.62)-8.4(.)-449.9(Predic)-8.6(tive)-457.8(equations)-463.2(for)-455(FL)-454.4(and)-457.9(non-FL)-459.1(patien)-10.2(ts)]TJ
T*
[(wer)-8.2(e,)-331.6(respec)-8.6(tive)-8.2(ly:)]TJ
/F10 1 Tf
4.5411 -1.4511 TD
(P)Tj
/F11 1 Tf
6.974 0 0 6.974 361.19 654.519 Tm
(a)Tj
/F13 1 Tf
0.504 0 TD
(;)Tj
/F11 1 Tf
0.2683 0 TD
0.0001 Tc
(CO)Tj
4.981 0 0 4.981 377.008 653.442 Tm
0 Tc
(2)Tj
/F12 1 Tf
9.963 0 0 9.963 383.244 654.293 Tm
(\210)Tj
/F11 1 Tf
1.0527 0 TD
(8)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
(1)Tj
/F12 1 Tf
6.974 0 0 6.974 406.431 655.37 Tm
(\377)Tj
/F11 1 Tf
9.963 0 0 9.963 412.271 654.293 Tm
(0)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
[(04)-337.3(IC)]TJ
/F8 1 Tf
6.974 0 0 6.974 444.302 655.37 Tm
(+)Tj
/F11 1 Tf
9.963 0 0 9.963 451.786 654.293 Tm
(0)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
(7)Tj
/F12 1 Tf
0.8308 0 TD
(\205)Tj
/F11 1 Tf
6.974 0 0 6.974 471.628 654.519 Tm
0.0001 Tc
(SEM)Tj
/F12 1 Tf
9.963 0 0 9.963 487.446 654.293 Tm
3.2626 Tc
(\206\205)Tj
/F14 1 Tf
4.0346 0 TD
0 Tc
(8)Tj
/F12 1 Tf
0.5008 0 TD
(\206)Tj
/F10 1 Tf
-18.3691 -1.9063 TD
(P)Tj
/F11 1 Tf
6.974 0 0 6.974 356.258 635.527 Tm
(a)Tj
/F13 1 Tf
0.504 0 TD
(;)Tj
/F11 1 Tf
0.2683 0 TD
0.0001 Tc
(CO)Tj
4.981 0 0 4.981 372.076 634.507 Tm
0 Tc
(2)Tj
/F12 1 Tf
9.963 0 0 9.963 378.312 635.301 Tm
(\210)Tj
/F11 1 Tf
1.0527 0 TD
(7)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2675 0 TD
(2)Tj
/F12 1 Tf
6.974 0 0 6.974 401.442 636.434 Tm
(\377)Tj
/F11 1 Tf
9.963 0 0 9.963 407.338 635.301 Tm
(0)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
[(02)-337.3(FVC)]TJ
/F8 1 Tf
6.974 0 0 6.974 449.234 636.434 Tm
(+)Tj
/F11 1 Tf
9.963 0 0 9.963 456.718 635.301 Tm
(0)Tj
/F13 1 Tf
0.5008 0 TD
(:)Tj
/F11 1 Tf
0.2731 0 TD
(7)Tj
/F12 1 Tf
0.8365 0 TD
(\205)Tj
/F11 1 Tf
6.974 0 0 6.974 476.56 635.527 Tm
0.0001 Tc
(SEM)Tj
/F12 1 Tf
9.963 0 0 9.963 492.378 635.301 Tm
2.7676 Tc
(\206\205)Tj
/F14 1 Tf
3.5395 0 TD
0 Tc
(9)Tj
/F12 1 Tf
0.5008 0 TD
(\206)Tj
/F3 1 Tf
-21.4135 -1.9519 TD
[(Th)17.1(e)-479.2(c)0(o)15.1(r)0(r)18(e)0(l)18.4(a)0(t)12.8(i)0(o)18.8(n)-478.8(co)20.8(ef)24.9(fi)17.3(ci)18.5(en)15.1(ts)-471.7(fo)19.6(r)-480.4(t)0(h)18.8(e)0(s)19.6(e)-479.2(eq)15.1(ua)15.1(t)13.9(i)0(o)13.2(n)0(s)-469.3(w)0(e)16.9(r)0(e)]TJ
-1.0015 -1.0527 TD
[(0.)15.9(62)-314.5(an)15.1(d)-319.4(0)0(.)15.9(5)0(5)21.2(,)-324.7(re)13.5(sp)20(ec)14.7(ti)22.2(ve)15.1(ly)81.4(.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(er)13.5(e)-274.3(w)0(a)16.9(s)-280.8(no)-263.3(si)17.7(gn)15.5(if)17.3(ic)18.4(an)15.1(t)-276.3(d)0(i)18.9(f)20.4(fe)13.5(re)19.2(nc)15.1(e)-274.3(i)0(n)-265.7(b)0(r)13.9(e)0(a)20.4(t)0(h)13.2(i)13.9(ng)-269(pa)15.1(tt)16.5(er)19.2(n)]TJ
-1.0015 -1.0527 TD
[(be)15.1(tw)14.9(ee)20.4(n)-268.2(n)0(o)21.2(n)0(-)13.9(F)11.4(L)-266.7(a)0(n)15.1(d)-268.2(F)11.4(L)-266.7(pa)15.1(ti)22.2(en)15.1(ts)-255.5(\(t)11.6(ab)20.8(le)-260.4(3\).)-265.3(However)18.5(,)-273.5(both)]TJ
/F4 1 Tf
T*
(V)Tj
/F3 1 Tf
7.97 0 0 7.97 315.383 573.959 Tm
(T)Tj
9.963 0 0 9.963 322.979 573.959 Tm
(and)Tj
/F4 1 Tf
1.7868 0 TD
(t)Tj
/F3 1 Tf
7.97 0 0 7.97 343.502 573.959 Tm
(I)Tj
9.963 0 0 9.963 349.512 573.959 Tm
[(were)-350.8(signi)-9.8(ficantly)-357.1(lower)-353.6(in)-345.3(the)-352.2(17)-348.7(FL)-346.3(patients)]TJ
-4.0346 -1.0527 TD
[(who)-273.7(were)-265.5(h)-6.5(ypercap)-8.2(nic)-266.8(\()]TJ
/F4 1 Tf
9.617 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 411.137 563.471 Tm
(a,CO)Tj
7.472 0 0 6.641 427.635 561.77 Tm
(2)Tj
/F9 1 Tf
9.963 0 0 9.963 433.984 563.471 Tm
(>)Tj
/F3 1 Tf
0.552 0 TD
[(5.7)-269.4(kPa\))-271.7([19])-268(than)-267.6(in)-265.7(the)]TJ
-13.0655 -1.0584 TD
[(12)-172.3(nonhyper)-8.1(capnic)-173.2(FL)-169.9(patients)-174.6(\(0.576\2130.0)-7.3(4)]TJ
/F4 1 Tf
17.305 0 TD
(versus)Tj
/F3 1 Tf
2.703 0 TD
(0.792\213)Tj
-20.008 -1.0528 TD
[(0.09)-605.9(L,)-602.8(p)]TJ
/F9 1 Tf
4.3134 0 TD
(<)Tj
/F3 1 Tf
0.552 0 TD
[(0.03,)-606.2(and)-600.2(0.99\213)-8(0.07)]TJ
/F4 1 Tf
9.2927 0 TD
(versus)Tj
/F3 1 Tf
3.1412 0 TD
[(1.35\2130.08)-608.1(L,)]TJ
-17.2993 -1.0527 TD
(p)Tj
/F9 1 Tf
0.5008 0 TD
(<)Tj
/F3 1 Tf
0.5577 0 TD
[(0.005,)-185.9(respec)-8.6(tive)-8.2(ly\).)-188.7(In)-190.9(the)-187.2(hyperca)-8.1(pnic)-187.9(FL)-192.7(patients,)-192(the)]TJ
-1.0584 -1.0527 TD
[(IC)-400.5(\(%)-403.8(pred\))-400.1(was)-400.5(lower)-404.8(than)-398.5(in)-402.3(the)-397.7(nonhyper)-8.1(capnic)-400.8(FL)]TJ
T*
[(pati)-8.2(ents)-337.1(\(53\2132)]TJ
/F4 1 Tf
6.1173 0 TD
(versus)Tj
/F3 1 Tf
2.868 0 TD
[(71\2133)-337.6(%)-333.2(pred;)-343.9(p)]TJ
/F9 1 Tf
6.4076 0 TD
(<)Tj
/F3 1 Tf
0.552 0 TD
(0.0001\).)Tj
-14.9434 -1.0471 TD
[(Th)17.1(er)13.5(e)-336.9(w)0(a)16.9(s)-343.4(no)-331.6(si)17.7(gn)21.2(if)17.3(ic)18.4(an)15.1(t)-338.9(d)0(i)18.9(f)14.7(fe)19.2(re)19.2(nc)15.1(e)-342.6(i)13.9(n)]TJ
/F4 1 Tf
15.5523 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 480.189 500.542 Tm
0.0001 Tc
[(I,)24.4(ma)19.2(x)]TJ
9.963 0 0 9.963 501.392 500.542 Tm
0 Tc
[(\(%)-329.8(pr)13.9(ed)20.8(\))]TJ
-19.2796 -1.0528 TD
[(be)15.1(tw)14.9(ee)20.4(n)-342.2(t)0(h)18.9(e)-342.6(FL)-334.9(an)20.8(d)-342.2(n)0(o)15.5(n)0(-)19.6(F)0(L)-334.9(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)17.7(.)-341.8(A)-255.1(w)0(e)16.9(a)0(k)-337.7(c)0(o)20.8(r)0(r)18(e)0(l)12.8(a)0(t)18.5(i)0(o)18.8(n)]TJ
T*
[(wa)16.9(s)-457.2(f)0(o)19.6(u)0(n)15.5(d)-450.3(of)]TJ
/F4 1 Tf
5.9865 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 374.853 479.565 Tm
[(I,)17.2(m)16(a)0(x)]TJ
9.963 0 0 9.963 397.19 479.565 Tm
[(\(%)-449.4(pr)19.6(ed)15.1(\))-451.9(t)0(o)-442.1(I)0(C)-446(\()0(%)-443.7(p)0(r)13.9(e)0(d)20.8(\))-457.6(\(r)]TJ
/F9 1 Tf
11.4551 0 TD
(=)Tj
/F3 1 Tf
0.5406 0 TD
[(0.)15.9(34)21.2(;)]TJ
-20.816 -1.0527 TD
(p)Tj
/F9 1 Tf
0.4951 0 TD
(<)Tj
/F3 1 Tf
0.5406 0 TD
[(0.)15.9(05)21.2(\).)-298.6(N)12.4(o)-308.1(si)17.7(gn)21.2(if)17.3(ic)12.8(an)20.8(t)-304.7(c)0(o)15.1(r)0(r)18(e)0(l)18.5(a)0(t)18.5(i)0(o)13.2(n)-302.4(wa)16.9(s)-303.6(f)0(o)19.6(u)0(n)15.5(d)-302.4(of)]TJ
/F4 1 Tf
18.4943 0 TD
(V)Tj
/F8 1 Tf
0.5918 0 TD
(')Tj
/F3 1 Tf
7.97 0 0 7.97 511.88 469.077 Tm
(O)Tj
7.472 0 0 6.641 517.549 467.376 Tm
(2)Tj
7.97 0 0 7.97 521.178 469.077 Tm
-0.0172 Tc
[(,m)-17.3(ax)]TJ
9.963 0 0 9.963 309.316 458.589 Tm
0 Tc
(to)Tj
/F4 1 Tf
1.1779 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 327.005 458.589 Tm
[(I,)17.2(m)16(a)0(x)]TJ
9.963 0 0 9.963 344.75 458.589 Tm
[(,)-415.8(w)0(h)17.3(i)0(l)16.5(e)-416.6(th)18.9(er)19.2(e)-416.6(w)0(a)11.2(s)-411.7(a)-416.6(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(t)0(,)-407.6(a)0(l)18.5(t)0(h)18.8(o)0(u)15.5(g)0(h)-405.6(l)0(o)18.8(o)0(s)14.4(e)0(,)]TJ
-3.5566 -1.0584 TD
[(co)15.1(rr)18(el)18.4(at)12.8(io)18.9(n)-325.1(b)0(e)20.8(t)0(w)14.9(e)0(e)20.4(n)]TJ
/F4 1 Tf
8.0749 0 TD
(W)Tj
/F3 1 Tf
0.8137 0 TD
(R)Tj
7.97 0 0 7.97 404.447 448.044 Tm
0.0001 Tc
[(ma)19.2(x)]TJ
9.963 0 0 9.963 421.115 448.044 Tm
0 Tc
[(an)20.8(d)]TJ
/F4 1 Tf
1.7413 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 444.416 448.044 Tm
0.0001 Tc
[(I,)24.4(ma)19.2(x)]TJ
9.963 0 0 9.963 465.449 448.044 Tm
0 Tc
(\(r)Tj
/F9 1 Tf
0.626 0 TD
(=)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(32)15.5(;)-321.8(p)]TJ
/F9 1 Tf
2.7941 0 TD
(<)Tj
/F3 1 Tf
0.5463 0 TD
[(0.)21.6(01)15.5(\).)]TJ
/F6 1 Tf
-11.0169 -3.6989 TD
[(Discu)-10.9(ssion)]TJ
/F3 1 Tf
-8.1659 -2.0998 TD
[(Th)17.1(e)-291.4(m)13.2(ai)12.8(n)-285.3(f)0(i)17.3(n)0(d)21.2(i)0(n)13.2(g)-285.3(of)-276.3(th)18.9(e)-285.7(p)0(r)13.9(e)0(s)19.6(e)0(n)15.1(t)-282(st)17.7(ud)15.5(y)-285.3(i)0(s)-278.2(t)0(h)18.9(a)0(t)18.5(,)-290.6(in)-277.1(C)11.6(O)0(P)12.4(D)]TJ
-1.0015 -1.0528 TD
[(pa)15.1(ti)16.5(en)20.8(ts)17.7(,)-626.3(d)0(e)20.8(t)0(e)12.8(c)0(t)18.4(i)0(o)18.8(n)-621(of)-617.7(ex)20.8(pi)13.2(ra)19.2(to)18.8(ry)-617.7(F)11.4(L)-625.2(at)-613.2(re)13.5(st)-614(pl)18.9(ay)20.8(s)-627.9(a)0(n)]TJ
T*
[(im)15.7(po)15.5(rt)17.3(an)20.8(t)-287.7(r)0(o)19.6(l)0(e)-277.5(i)0(n)-271.4(i)0(d)13.2(e)0(n)20.8(t)0(i)16.5(f)0(y)19.6(i)0(n)13.2(g)-279.6(th)13.2(e)-280(f)0(a)13.5(c)0(t)18.4(o)0(r)19.6(s)-286.5(th)18.9(at)-277.5(li)16.5(mi)21.4(t)-287.7(e)0(x)20.8(e)0(r)13.5(c)0(i)18.5(s)0(e)]TJ
T*
[(to)13.2(le)18.4(ra)19.2(nc)15.1(e.)-320.2(In)-316.1(th)13.2(os)20(e)-331.2(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-318.1(w)0(i)14.9(t)0(h)-316.9(F)0(L)12.2(,)-324.7(th)18.8(e)-331.2(s)0(o)20(l)0(e)-323(p)0(r)19.6(e)0(d)15.1(i)0(c)18.5(t)0(o)18.8(r)-332.4(of)]TJ
T*
[(ex)15.1(er)19.2(ci)12.8(se)-526.7(ca)14.7(pa)20.8(ci)12.8(t)13.9(y)-541.4(wa)16.9(s)-542.6(I)0(C)20.6(,)-541(wh)17.3(er)19.2(ea)14.7(s)-536.9(i)0(n)-533.1(n)0(o)21.2(n)0(-)13.9(F)11.4(L)-539.8(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)]TJ
T*
[(FE)17.9(V)]TJ
7.97 0 0 7.97 327.742 337.833 Tm
(1)Tj
9.963 0 0 9.963 331.653 337.833 Tm
[(/F)19.6(VC)-198(wa)16.9(s)-206.8(t)0(h)18.9(e)-206(be)15.1(st)-192.9(pr)19.6(ed)15.1(ic)18.4(to)18.9(r)60.2(.)-205.2(In)-196.6(ad)15.1(di)18.8(ti)16.5(on)21.2(,)-205.2(i)0(t)-194.1(w)0(a)16.9(s)-206.8(fo)19.6(un)15.5(d)]TJ
-2.2421 -1.0527 TD
[(th)13.2(at)-283.1(1\))-282(in)-288.4(al)18.4(l)-293.4(n)0(o)15.5(n)0(-)19.6(F)11.4(L)-295.1(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-283.9(I)0(C)-286.7(w)0(a)16.9(s)-292.2(wi)14.9(th)18.9(in)-288.4(no)21.2(rm)16.5(al)-288.8(l)13.9(i)0(m)15.7(i)0(t)16.5(s)]TJ
T*
[(an)15.1(d)-199.9(i)0(n)-197.4(t)0(h)18.9(e)-200.3(ma)12(j)13.9(o)0(r)14(i)0(t)16.5(y)-199.9(of)-196.6(F)11.4(L)-204.1(su)20(bj)18.9(ec)14.7(ts)-192.9(th)18.9(e)-206(I)0(C)-195.6(w)12.4(as)-196.6(be)20.8(lo)13.2(w)-198.2(n)0(o)15.5(r)0(m)16.5(a)0(l)]TJ
T*
[(li)16.5(mi)15.7(ts)17.7(;)-361.7(a)0(n)15.1(d)-359.3(2\))-355.9(in)-351(al)12.8(l)-361.6(F)11.4(L)-363.4(s)0(u)20(b)0(j)13.2(e)0(c)20.4(t)0(s)]TJ
/F4 1 Tf
13.2135 0 TD
(V)Tj
/F8 1 Tf
0.5975 0 TD
(')Tj
/F3 1 Tf
7.97 0 0 7.97 449.008 306.368 Tm
(O)Tj
7.472 0 0 6.641 454.62 304.724 Tm
(2)Tj
7.97 0 0 7.97 458.249 306.368 Tm
[(,m)17(ax)]TJ
9.963 0 0 9.963 477.184 306.368 Tm
[(wa)11.2(s)-360.5(d)0(e)20.8(c)0(r)13.5(e)0(a)20.4(s)0(e)13.9(d)0(,)]TJ
-16.8497 -1.0528 TD
[(wh)17.3(er)13.5(ea)20.4(s)-206.8(i)0(n)-191.7(3)0(5)21.2(%)-208(of)-190.9(th)18.9(e)-206(n)0(o)21.2(n)0(-)14(F)11.4(L)-204.1(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)]TJ
/F4 1 Tf
15.1141 0 TD
(V)Tj
/F8 1 Tf
0.5975 0 TD
(')Tj
/F3 1 Tf
7.97 0 0 7.97 467.886 295.88 Tm
(O)Tj
7.472 0 0 6.641 473.556 294.179 Tm
(2)Tj
7.97 0 0 7.97 477.184 295.88 Tm
[(,m)24.1(ax)]TJ
9.963 0 0 9.963 494.532 295.88 Tm
[(wa)16.9(s)-201.1(w)0(i)14.9(t)0(h)18.8(i)0(n)]TJ
-18.591 -1.0527 TD
[(no)15.5(rm)16.5(al)-317.3(li)16.5(mi)15.7(t)13.9(s)0(.)]TJ
ET
0 0 0 1 K
0 J 0 j 0.5 w 3.864 M []0 d
/GS3 gs
1 i 
194.944 543.894 m
240.378 543.894 l
106.107 607.649 m
106.107 480.142 l
106.371 607.457 m
103.629 607.457 l
106.371 586.99 m
103.629 586.99 l
106.371 565.812 m
103.629 565.812 l
106.371 544.775 m
103.629 544.775 l
106.371 502.419 m
103.629 502.419 l
272.483 480.386 m
103.629 480.386 l
S
BT
/F19 1 Tf
10 0 0 10 97.412 476.217 Tm
0 0 0 1 k
/GS4 gs
(0)Tj
ET
/GS3 gs
160.49 480.475 m
160.49 477.734 l
216.404 480.475 m
216.404 477.734 l
272.243 480.475 m
272.243 477.734 l
S
BT
10 0 0 10 92.661 498.622 Tm
/GS4 gs
(20)Tj
0 2.0424 TD
(40)Tj
ET
/GS3 gs
106.371 523.177 m
103.629 523.177 l
S
BT
10 0 0 10 92.661 540.77 Tm
/GS4 gs
(60)Tj
0 2.0714 TD
(80)Tj
-0.4558 2.1309 TD
(100)Tj
0 2.0587 TD
(120)Tj
0 10 -10 0 85.653 530.977 Tm
(IC % pred)Tj
10 0 0 10 73.692 607.649 Tm
(a\))Tj
/F22 1 Tf
6 0 0 6 136.391 583.823 Tm
(l)Tj
ET
0 0 0 0 k
3.864 M 
/GS3 gs
226.661 565.943 m
226.661 567.116 227.613 568.068 228.786 568.068 c
229.96 568.068 230.911 567.116 230.911 565.943 c
230.911 564.769 229.96 563.818 228.786 563.818 c
227.613 563.818 226.661 564.769 226.661 565.943 c
b
BT
6 0 0 6 142.069 588.223 Tm
0 0 0 1 k
/GS4 gs
(l)Tj
0.985 0.387 TD
(l)Tj
1.8171 0.1936 TD
(l)Tj
1.8365 -0.6192 TD
(l)Tj
0.9076 -0.2129 TD
(l)Tj
0.9656 -0.5593 TD
(l)Tj
-0.0387 -1.8364 TD
(l)Tj
-1.8346 -0.7528 TD
(l)Tj
-0.9288 -0.2322 TD
(l)Tj
-0.985 -0.5225 TD
(l)Tj
-0.8882 0.7353 TD
(l)Tj
-0.9288 -0.0194 TD
(l)Tj
-1.8926 0.985 TD
(l)Tj
0.9657 0.3483 TD
(l)Tj
0.9076 -0.0193 TD
(l)Tj
0.9675 -0.716 TD
(l)Tj
0.8689 -0.0581 TD
(l)Tj
1.0044 -0.0387 TD
(l)Tj
0.8514 0.2516 TD
(l)Tj
0.9657 0.6966 TD
(l)Tj
-2.7828 0.6948 TD
(l)Tj
0.0193 0.6579 TD
(l)Tj
ET
3.864 M 
/GS3 gs
137.936 579.48 m
183.266 579.48 l
S
0 0 0 0 k
3.864 M 
220.739 566.431 m
220.739 567.605 221.69 568.556 222.864 568.556 c
224.037 568.556 224.989 567.605 224.989 566.431 c
224.989 565.258 224.037 564.306 222.864 564.306 c
221.69 564.306 220.739 565.258 220.739 566.431 c
b
215.06 569.486 m
215.06 570.66 216.012 571.611 217.185 571.611 c
218.359 571.611 219.31 570.66 219.31 569.486 c
219.31 568.313 218.359 567.361 217.185 567.361 c
216.012 567.361 215.06 568.313 215.06 569.486 c
b
203.883 566.065 m
203.883 567.238 204.835 568.19 206.008 568.19 c
207.182 568.19 208.133 567.238 208.133 566.065 c
208.133 564.891 207.182 563.94 206.008 563.94 c
204.835 563.94 203.883 564.891 203.883 566.065 c
b
209.382 564.785 m
209.382 565.959 210.333 566.91 211.507 566.91 c
212.681 566.91 213.632 565.959 213.632 564.785 c
213.632 563.612 212.681 562.66 211.507 562.66 c
210.333 562.66 209.382 563.612 209.382 564.785 c
b
215.305 561.242 m
215.305 562.415 216.256 563.367 217.43 563.367 c
218.603 563.367 219.555 562.415 219.555 561.242 c
219.555 560.068 218.603 559.117 217.43 559.117 c
216.256 559.117 215.305 560.068 215.305 561.242 c
b
209.26 553.486 m
209.26 554.66 210.211 555.611 211.385 555.611 c
212.558 555.611 213.51 554.66 213.51 553.486 c
213.51 552.313 212.558 551.361 211.385 551.361 c
210.211 551.361 209.26 552.313 209.26 553.486 c
b
214.938 554.83 m
214.938 556.004 215.889 556.955 217.063 556.955 c
218.237 556.955 219.188 556.004 219.188 554.83 c
219.188 553.657 218.237 552.705 217.063 552.705 c
215.889 552.705 214.938 553.657 214.938 554.83 c
b
220.861 553.853 m
220.861 555.026 221.812 555.978 222.986 555.978 c
224.159 555.978 225.111 555.026 225.111 553.853 c
225.111 552.679 224.159 551.728 222.986 551.728 c
221.812 551.728 220.861 552.679 220.861 553.853 c
b
220.739 549.21 m
220.739 550.383 221.69 551.335 222.864 551.335 c
224.037 551.335 224.989 550.383 224.989 549.21 c
224.989 548.036 224.037 547.085 222.864 547.085 c
221.69 547.085 220.739 548.036 220.739 549.21 c
b
209.26 548.174 m
209.26 549.348 210.211 550.3 211.385 550.3 c
212.558 550.3 213.51 549.348 213.51 548.174 c
213.51 547.001 212.558 546.049 211.385 546.049 c
210.211 546.049 209.26 547.001 209.26 548.174 c
b
203.517 545.242 m
203.517 546.416 204.468 547.367 205.642 547.367 c
206.815 547.367 207.767 546.416 207.767 545.242 c
207.767 544.068 206.815 543.117 205.642 543.117 c
204.468 543.117 203.517 544.068 203.517 545.242 c
b
197.716 544.142 m
197.716 545.316 198.668 546.267 199.841 546.267 c
201.015 546.267 201.966 545.316 201.966 544.142 c
201.966 542.969 201.015 542.017 199.841 542.017 c
198.668 542.017 197.716 542.969 197.716 544.142 c
b
220.494 543.287 m
220.494 544.46 221.446 545.412 222.619 545.412 c
223.793 545.412 224.744 544.46 224.744 543.287 c
224.744 542.113 223.793 541.162 222.619 541.162 c
221.446 541.162 220.494 542.113 220.494 543.287 c
b
226.359 541.21 m
226.359 542.383 227.311 543.335 228.484 543.335 c
229.658 543.335 230.609 542.383 230.609 541.21 c
230.609 540.036 229.658 539.085 228.484 539.085 c
227.311 539.085 226.359 540.036 226.359 541.21 c
b
232.038 539.93 m
232.038 541.104 232.989 542.055 234.163 542.055 c
235.336 542.055 236.288 541.104 236.288 539.93 c
236.288 538.757 235.336 537.805 234.163 537.805 c
232.989 537.805 232.038 538.757 232.038 539.93 c
b
226.237 536.265 m
226.237 537.438 227.189 538.389 228.362 538.389 c
229.536 538.389 230.487 537.438 230.487 536.265 c
230.487 535.091 229.536 534.139 228.362 534.139 c
227.189 534.139 226.237 535.091 226.237 536.265 c
b
220.739 536.753 m
220.739 537.927 221.69 538.878 222.864 538.878 c
224.037 538.878 224.989 537.927 224.989 536.753 c
224.989 535.58 224.037 534.628 222.864 534.628 c
221.69 534.628 220.739 535.58 220.739 536.753 c
b
231.916 528.753 m
231.916 529.927 232.867 530.878 234.041 530.878 c
235.214 530.878 236.166 529.927 236.166 528.753 c
236.166 527.58 235.214 526.628 234.041 526.628 c
232.867 526.628 231.916 527.58 231.916 528.753 c
b
226.237 529.609 m
226.237 530.782 227.189 531.733 228.362 531.733 c
229.536 531.733 230.487 530.782 230.487 529.609 c
230.487 528.435 229.536 527.483 228.362 527.483 c
227.189 527.483 226.237 528.435 226.237 529.609 c
b
209.382 541.576 m
209.382 542.75 210.333 543.701 211.507 543.701 c
212.681 543.701 213.632 542.75 213.632 541.576 c
213.632 540.403 212.681 539.451 211.507 539.451 c
210.333 539.451 209.382 540.403 209.382 541.576 c
b
209.138 536.876 m
209.138 538.049 210.089 539.001 211.263 539.001 c
212.436 539.001 213.388 538.049 213.388 536.876 c
213.388 535.702 212.436 534.75 211.263 534.75 c
210.089 534.75 209.138 535.702 209.138 536.876 c
b
203.517 537.853 m
203.517 539.026 204.468 539.978 205.642 539.978 c
206.815 539.978 207.767 539.026 207.767 537.853 c
207.767 536.679 206.815 535.728 205.642 535.728 c
204.468 535.728 203.517 536.679 203.517 537.853 c
b
203.395 532.839 m
203.395 534.012 204.346 534.964 205.52 534.964 c
206.693 534.964 207.645 534.012 207.645 532.839 c
207.645 531.665 206.693 530.714 205.52 530.714 c
204.346 530.714 203.395 531.665 203.395 532.839 c
b
197.716 530.83 m
197.716 532.004 198.668 532.955 199.841 532.955 c
201.015 532.955 201.966 532.004 201.966 530.83 c
201.966 529.657 201.015 528.705 199.841 528.705 c
198.668 528.705 197.716 529.657 197.716 530.83 c
b
209.138 526.309 m
209.138 527.483 210.089 528.434 211.263 528.434 c
212.436 528.434 213.388 527.483 213.388 526.309 c
213.388 525.136 212.436 524.184 211.263 524.184 c
210.089 524.184 209.138 525.136 209.138 526.309 c
b
209.015 521.242 m
209.015 522.416 209.967 523.367 211.14 523.367 c
212.314 523.367 213.265 522.416 213.265 521.242 c
213.265 520.068 212.314 519.117 211.14 519.117 c
209.967 519.117 209.015 520.068 209.015 521.242 c
b
220.494 527.287 m
220.494 528.461 221.446 529.412 222.619 529.412 c
223.793 529.412 224.744 528.461 224.744 527.287 c
224.744 526.113 223.793 525.162 222.619 525.162 c
221.446 525.162 220.494 526.113 220.494 527.287 c
b
220.25 520.998 m
220.25 522.171 221.201 523.123 222.375 523.123 c
223.549 523.123 224.5 522.171 224.5 520.998 c
224.5 519.824 223.549 518.873 222.375 518.873 c
221.201 518.873 220.25 519.824 220.25 520.998 c
b
3.864 M 
191.797 374.287 m
237.655 374.287 l
106.107 460.65 m
106.107 334.772 l
106.371 460.458 m
103.629 460.458 l
106.371 434.751 m
103.629 434.751 l
106.371 409.934 m
103.629 409.934 l
106.371 384.788 m
103.629 384.788 l
106.371 359.655 m
103.629 359.655 l
272.498 334.767 m
103.629 334.767 l
S
BT
/F19 1 Tf
10 0 0 10 97.412 330.892 Tm
0 0 0 1 k
/GS4 gs
(0)Tj
ET
/GS3 gs
160.49 334.686 m
160.49 331.944 l
216.404 334.686 m
216.404 331.944 l
272.243 334.686 m
272.243 331.944 l
S
BT
10 0 0 10 92.661 355.482 Tm
/GS4 gs
(20)Tj
0 2.5417 TD
(40)Tj
0 2.4887 TD
(60)Tj
0 2.4824 TD
(80)Tj
-0.4558 2.5771 TD
(100)Tj
0 10 -10 0 85.653 383.977 Tm
(FEV)Tj
0 8 -8 0 85.653 399.927 Tm
(1)Tj
0 10 -10 0 85.653 403.575 Tm
( % pred)Tj
10 0 0 10 73.692 460.65 Tm
(b\))Tj
/F22 1 Tf
6 0 0 6 163.327 435.46 Tm
(l)Tj
-1.8527 1.9369 TD
(l)Tj
0.9497 -3.039 TD
(l)Tj
-0.9041 0.5739 TD
(l)Tj
ET
0 0 0 0 k
3.864 M 
/GS3 gs
219.769 399.48 m
219.769 400.654 220.72 401.605 221.894 401.605 c
223.067 401.605 224.019 400.654 224.019 399.48 c
224.019 398.306 223.067 397.355 221.894 397.355 c
220.72 397.355 219.769 398.306 219.769 399.48 c
b
208.053 396.52 m
208.053 397.694 209.005 398.645 210.178 398.645 c
211.352 398.645 212.303 397.694 212.303 396.52 c
212.303 395.347 211.352 394.395 210.178 394.395 c
209.005 394.395 208.053 395.347 208.053 396.52 c
b
208.164 390.441 m
208.164 391.615 209.115 392.566 210.289 392.566 c
211.462 392.566 212.414 391.615 212.414 390.441 c
212.414 389.268 211.462 388.316 210.289 388.316 c
209.115 388.316 208.164 389.268 208.164 390.441 c
b
219.952 390.632 m
219.952 391.806 220.903 392.757 222.077 392.757 c
223.25 392.757 224.202 391.806 224.202 390.632 c
224.202 389.459 223.25 388.507 222.077 388.507 c
220.903 388.507 219.952 389.459 219.952 390.632 c
b
219.725 385.792 m
219.725 386.966 220.676 387.917 221.85 387.917 c
223.023 387.917 223.975 386.966 223.975 385.792 c
223.975 384.619 223.023 383.667 221.85 383.667 c
220.676 383.667 219.725 384.619 219.725 385.792 c
b
BT
6 0 0 6 163.377 428.264 Tm
0 0 0 1 k
/GS4 gs
(l)Tj
-1.9201 -0.5219 TD
(l)Tj
1.9201 -0.6167 TD
(l)Tj
-1.8552 -1.2035 TD
(l)Tj
1.8552 -0.7466 TD
(l)Tj
-0.9763 -0.0675 TD
(l)Tj
-0.8789 -0.3246 TD
(l)Tj
-0.0649 -0.8439 TD
(l)Tj
1.8227 -0.4569 TD
(l)Tj
0 -0.7466 TD
(l)Tj
0.9438 -1.1061 TD
(l)Tj
-1.8552 0.2597 TD
(l)Tj
-0.9114 0.4245 TD
(l)Tj
-0.9413 -0.7791 TD
(l)Tj
0.9413 -0.9788 TD
(l)Tj
0.9438 -0.0974 TD
(l)Tj
-0.9114 -0.8464 TD
(l)Tj
1.7903 1.1385 TD
(l)Tj
0.0324 -0.7465 TD
(l)Tj
ET
3.864 M 
/GS3 gs
137.161 407.455 m
181.85 407.455 l
S
0 0 0 0 k
3.864 M 
208.009 384.624 m
208.009 385.797 208.961 386.749 210.134 386.749 c
211.308 386.749 212.259 385.797 212.259 384.624 c
212.259 383.45 211.308 382.499 210.134 382.499 c
208.961 382.499 208.009 383.45 208.009 384.624 c
b
202.541 381.67 m
202.541 382.844 203.492 383.795 204.666 383.795 c
205.84 383.795 206.791 382.844 206.791 381.67 c
206.791 380.497 205.84 379.545 204.666 379.545 c
203.492 379.545 202.541 380.497 202.541 381.67 c
b
196.699 375.066 m
196.699 376.239 197.65 377.191 198.823 377.191 c
199.997 377.191 200.948 376.239 200.948 375.066 c
200.948 373.892 199.997 372.941 198.823 372.941 c
197.65 372.941 196.699 373.892 196.699 375.066 c
b
202.541 376.786 m
202.541 377.96 203.492 378.911 204.666 378.911 c
205.84 378.911 206.791 377.96 206.791 376.786 c
206.791 375.613 205.84 374.661 204.666 374.661 c
203.492 374.661 202.541 375.613 202.541 376.786 c
b
208.204 377.403 m
208.204 378.577 209.155 379.528 210.329 379.528 c
211.503 379.528 212.454 378.577 212.454 377.403 c
212.454 376.229 211.503 375.278 210.329 375.278 c
209.155 375.278 208.204 376.229 208.204 377.403 c
b
219.725 380.13 m
219.725 381.303 220.676 382.255 221.85 382.255 c
223.023 382.255 223.975 381.303 223.975 380.13 c
223.975 378.956 223.023 378.004 221.85 378.004 c
220.676 378.004 219.725 378.956 219.725 380.13 c
b
225.21 376.969 m
225.21 378.143 226.161 379.094 227.335 379.094 c
228.509 379.094 229.46 378.143 229.46 376.969 c
229.46 375.796 228.509 374.844 227.335 374.844 c
226.161 374.844 225.21 375.796 225.21 376.969 c
b
225.21 373.853 m
225.21 375.027 226.161 375.978 227.335 375.978 c
228.509 375.978 229.46 375.027 229.46 373.853 c
229.46 372.68 228.509 371.728 227.335 371.728 c
226.161 371.728 225.21 372.68 225.21 373.853 c
b
219.547 375.455 m
219.547 376.629 220.498 377.58 221.672 377.58 c
222.846 377.58 223.797 376.629 223.797 375.455 c
223.797 374.282 222.846 373.331 221.672 373.331 c
220.498 373.331 219.547 374.282 219.547 375.455 c
b
207.859 372.933 m
207.859 374.107 208.81 375.058 209.984 375.058 c
211.157 375.058 212.109 374.107 212.109 372.933 c
212.109 371.76 211.157 370.808 209.984 370.808 c
208.81 370.808 207.859 371.76 207.859 372.933 c
b
213.521 371.181 m
213.521 372.354 214.473 373.306 215.646 373.306 c
216.82 373.306 217.772 372.354 217.772 371.181 c
217.772 370.007 216.82 369.056 215.646 369.056 c
214.473 369.056 213.521 370.007 213.521 371.181 c
b
219.515 370.766 m
219.515 371.94 220.466 372.891 221.64 372.891 c
222.813 372.891 223.765 371.94 223.765 370.766 c
223.765 369.592 222.813 368.641 221.64 368.641 c
220.466 368.641 219.515 369.592 219.515 370.766 c
b
196.699 362.766 m
196.699 363.94 197.65 364.891 198.823 364.891 c
199.997 364.891 200.948 363.94 200.948 362.766 c
200.948 361.593 199.997 360.641 198.823 360.641 c
197.65 360.641 196.699 361.593 196.699 362.766 c
b
202.346 368.429 m
202.346 369.603 203.298 370.554 204.471 370.554 c
205.645 370.554 206.596 369.603 206.596 368.429 c
206.596 367.256 205.645 366.304 204.471 366.304 c
203.298 366.304 202.346 367.256 202.346 368.429 c
b
202.346 364.681 m
202.346 365.855 203.298 366.807 204.471 366.807 c
205.645 366.807 206.596 365.855 206.596 364.681 c
206.596 363.508 205.645 362.557 204.471 362.557 c
203.298 362.557 202.346 363.508 202.346 364.681 c
b
208.009 366.676 m
208.009 367.85 208.961 368.801 210.134 368.801 c
211.308 368.801 212.259 367.85 212.259 366.676 c
212.259 365.503 211.308 364.551 210.134 364.551 c
208.961 364.551 208.009 365.503 208.009 366.676 c
b
207.832 360.429 m
207.832 361.603 208.783 362.554 209.957 362.554 c
211.13 362.554 212.082 361.603 212.082 360.429 c
212.082 359.256 211.13 358.304 209.957 358.304 c
208.783 358.304 207.832 359.256 207.832 360.429 c
b
207.62 356.534 m
207.62 357.708 208.571 358.659 209.745 358.659 c
210.918 358.659 211.87 357.708 211.87 356.534 c
211.87 355.36 210.918 354.409 209.745 354.409 c
208.571 354.409 207.62 355.36 207.62 356.534 c
b
213.716 365.922 m
213.716 367.096 214.668 368.047 215.841 368.047 c
217.015 368.047 217.966 367.096 217.966 365.922 c
217.966 364.748 217.015 363.797 215.841 363.797 c
214.668 363.797 213.716 364.748 213.716 365.922 c
b
219.562 366.243 m
219.562 367.417 220.513 368.368 221.687 368.368 c
222.861 368.368 223.812 367.417 223.812 366.243 c
223.812 365.069 222.861 364.118 221.687 364.118 c
220.513 364.118 219.562 365.069 219.562 366.243 c
b
230.8 363.505 m
230.8 364.679 231.752 365.63 232.925 365.63 c
234.099 365.63 235.05 364.679 235.05 363.505 c
235.05 362.332 234.099 361.38 232.925 361.38 c
231.752 361.38 230.8 362.332 230.8 363.505 c
b
225.332 363.715 m
225.332 364.888 226.284 365.84 227.457 365.84 c
228.631 365.84 229.582 364.888 229.582 363.715 c
229.582 362.541 228.631 361.59 227.457 361.59 c
226.284 361.59 225.332 362.541 225.332 363.715 c
b
219.335 359.066 m
219.335 360.24 220.286 361.191 221.46 361.191 c
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b
219.184 353.599 m
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3.864 M 
106.107 314.033 m
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106.371 314.033 m
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106.371 266.735 m
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(c\))Tj
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3.864 M 
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3.864 M 
137.161 261.956 m
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106.371 282.323 m
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BT
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BT
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3.864 M 
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b
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b
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b
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b
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b
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b
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b
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b
3.864 M 
193.199 245.936 m
238.705 245.936 l
S
BT
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(1)Tj
7.97 0 0 7.97 190.148 113.839 Tm
[(\(FL\))-326.7(and)-334.1(FVC)-325.9(respectively)70.5(.)]TJ
ET
309.316 234.709 227.168 -0.51 re
f
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f
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f
BT
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[(O.)-336.9(DIAZ)-338.9(ET)-256.2(AL.)]TJ
ET
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T*
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T*
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T*
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T*
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T*
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T*
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T*
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T*
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T*
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T*
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T*
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T*
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T*
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T*
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T*
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T*
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(1)Tj
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0 -1.0584 TD
[(th)13.2(e)-319.8(F)0(E)17.9(V)]TJ
7.97 0 0 7.97 342.822 422.305 Tm
(1)Tj
9.963 0 0 9.963 346.734 422.305 Tm
[(/F)19.6(VC)-317.5(ra)13.5(ti)16.5(o)-319.4(a)0(r)13.5(e)-319.8(th)13.2(e)-319.8(b)0(e)15.1(s)0(t)-318.1(p)0(r)19.6(e)0(d)15.1(i)13.9(ct)12.8(or)19.6(s.)]TJ
-2.7542 -1.0528 TD
[(In)-287.7(ou)21.2(r)-292.6(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)17.7(,)-290.6(th)13.2(e)]TJ
/F4 1 Tf
7.7278 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 402.179 411.817 Tm
[(a,)18.4(O)]TJ
7.472 0 0 6.641 413.121 410.173 Tm
(2)Tj
9.963 0 0 9.963 419.754 411.817 Tm
[(wa)16.9(s,)-286.9(on)-280.4(av)20.8(er)13.5(ag)20.8(e,)-286.1(si)17.7(gn)21.2(if)17.3(ic)12.8(an)20.8(tl)16.5(y)]TJ
-11.0852 -1.0641 TD
[(lo)13.2(w)12.4(e)0(r)47.7(,)-233.7(an)15.1(d)-228.4(t)0(h)18.9(e)]TJ
/F4 1 Tf
5.7304 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 372.359 401.216 Tm
0.0001 Tc
[(a,)25.6(CO)]TJ
7.472 0 0 6.641 388.516 399.572 Tm
0 Tc
(2)Tj
9.963 0 0 9.963 394.526 401.216 Tm
[(si)17.7(gn)15.5(if)17.3(ic)18.4(an)15.1(tl)16.5(y)-228.4(h)0(i)13.2(g)0(h)21.2(e)0(r)-225.5(i)0(n)-225.8(t)13.9(he)-223.9(FL)-226.8(th)18.9(an)-223.9(in)]TJ
-8.5529 -1.0584 TD
[(th)13.2(e)-319.8(n)0(o)21.2(n)0(-)19.6(F)0(L)-312.2(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)17.7(.)-319.1(Fi)13.9(ft)17.3(y-)19.6(ni)18.9(ne)-309.2(pe)15.1(rc)19.2(en)15.1(t)-316.1(o)0(f)-310.4(t)0(h)13.2(e)-319.9(F)11.4(L)-317.9(pa)15.1(ti)16.5(en)20.8(ts)]TJ
0 -1.0641 TD
[(we)16.9(re)-191.3(hy)15.5(pe)20.8(rc)13.5(ap)20.8(ni)18.9(c)-200.3(i)0(n)-186(c)0(o)15.1(m)0(p)18.1(a)0(r)19.2(i)0(s)17.7(o)0(n)-189.3(w)0(i)14.9(t)0(h)-186(o)0(n)15.5(l)0(y)-186(2)0(2)15.5(%)-196.6(of)-190.9(th)18.9(e)-194.7(n)0(o)15.5(n)0(-)]TJ
T*
[(FL)-266.6(pa)15.1(ti)16.5(en)20.8(ts)17.7(.)-273.5(I)0(C)-263.9(a)0(n)15.1(d)-273.9(F)11.4(V)0(C)-266.3(w)0(e)16.9(r)0(e)-265.3(s)0(e)13.9(l)0(e)18.4(c)0(t)18.5(e)0(d)-263.7(a)0(s)-264.9(s)0(i)17.7(g)0(n)15.5(i)0(f)17.3(i)0(c)18.4(a)0(n)15.1(t)-270.6(co)15.1(n-)]TJ
T*
[(tr)17.3(ib)13.2(ut)18.9(or)19.6(s)-258(t)0(o)]TJ
/F4 1 Tf
4.5411 0 TD
(P)Tj
/F3 1 Tf
7.97 0 0 7.97 360.51 358.866 Tm
0.0001 Tc
[(a,)25.6(CO)]TJ
7.472 0 0 6.641 376.668 357.222 Tm
0 Tc
(2)Tj
9.963 0 0 9.963 382.904 358.866 Tm
[(in)-248.6(t)13.9(h)0(e)-246.6(w)0(h)17.3(o)0(l)13.2(e)-251.6(gr)19.6(ou)15.5(p,)-245.8(bu)21.2(t)-259.2(I)0(C)-246.8(w)12.4(as)-247.8(th)18.8(e)-257.2(s)0(o)20(l)0(e)]TJ
-7.3863 -1.0641 TD
[(pr)13.9(ed)20.8(ic)12.8(t)13.9(o)0(r)-384.4(i)0(n)-385.2(F)0(L)-386.1(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)17.7(,)-387.3(su)14.3(gg)21.2(es)13.9(ti)16.5(ng)-382.8(th)18.8(at)-385.6(t)13.9(h)0(e)-388.9(p)0(r)19.6(e)0(s)19.6(e)0(n)15.1(c)0(e)-383.6(o)0(f)]TJ
T*
[(hy)15.5(pe)15.1(rc)19.2(ap)20.8(ni)13.2(a)-160.5(i)0(n)-151.9(t)0(h)13.2(i)13.9(s)-167(g)0(r)19.6(o)0(u)15.5(p)-160.1(is)-153.1(re)19.2(la)12.8(te)18.5(d)-160.1(t)0(o)-157.6(t)13.9(he)-155.6(de)15.1(gr)19.6(ee)-156(of)-151.1(DH)13.4(.)-159.7(T)0(h)17.1(e)]TJ
ET
0 0 0 1 K
0 J 0 j 0.5 w 3.864 M []0 d
/GS3 gs
1 i 
287.719 267.853 m
121.753 181.258 l
121.663 302.616 m
121.663 170.791 l
121.927 302.424 m
119.186 302.424 l
121.927 258.704 m
119.186 258.704 l
121.927 237.108 m
119.186 237.108 l
121.927 215.585 m
119.186 215.585 l
121.927 194.575 m
119.186 194.575 l
S
BT
/F19 1 Tf
10 0 0 10 108.218 190.402 Tm
0 0 0 1 k
/GS4 gs
(20)Tj
0 2.1295 TD
(40)Tj
0 2.1263 TD
(60)Tj
0 2.1603 TD
(80)Tj
-0.4558 4.3784 TD
(120)Tj
/F26 1 Tf
0 10 -10 0 100.367 210.285 Tm
(V)Tj
/F19 1 Tf
0.547 0 TD
('O)Tj
0 8 -8 0 103.202 223.705 Tm
(2)Tj
0.456 0.3543 TD
(max)Tj
0 10 -10 0 100.367 239.745 Tm
( \(% pred\))Tj
10 0 0 10 89.249 302.616 Tm
(a\))Tj
/F22 1 Tf
6 0 0 6 243.388 290.26 Tm
(l)Tj
3.8152 -4.9744 TD
(l)Tj
-1.3333 4.3231 TD
(l)Tj
ET
0 0 0 0 k
3.864 M 
/GS3 gs
225.882 245.482 m
225.882 246.656 226.834 247.608 228.007 247.608 c
229.181 247.608 230.132 246.656 230.132 245.482 c
230.132 244.309 229.181 243.358 228.007 243.358 c
226.834 243.358 225.882 244.309 225.882 245.482 c
b
231.571 229.575 m
231.571 230.749 232.523 231.701 233.696 231.701 c
234.87 231.701 235.821 230.749 235.821 229.575 c
235.821 228.402 234.87 227.45 233.696 227.45 c
232.523 227.45 231.571 228.402 231.571 229.575 c
b
236.498 234.537 m
236.498 235.71 237.45 236.662 238.623 236.662 c
239.797 236.662 240.748 235.71 240.748 234.537 c
240.748 233.363 239.797 232.412 238.623 232.412 c
237.45 232.412 236.498 233.363 236.498 234.537 c
b
229.794 223.532 m
229.794 224.705 230.746 225.657 231.919 225.657 c
233.093 225.657 234.044 224.705 234.044 223.532 c
234.044 222.358 233.093 221.407 231.919 221.407 c
230.746 221.407 229.794 222.358 229.794 223.532 c
b
231.769 224.242 m
231.769 225.415 232.721 226.366 233.894 226.366 c
235.068 226.366 236.019 225.415 236.019 224.242 c
236.019 223.068 235.068 222.116 233.894 222.116 c
232.721 222.116 231.769 223.068 231.769 224.242 c
b
232.424 226.776 m
232.424 227.949 233.376 228.901 234.549 228.901 c
235.723 228.901 236.674 227.949 236.674 226.776 c
236.674 225.602 235.723 224.651 234.549 224.651 c
233.376 224.651 232.424 225.602 232.424 226.776 c
b
3.864 M 
121.927 279.833 m
119.186 279.833 l
S
BT
/F19 1 Tf
10 0 0 10 103.66 275.756 Tm
0 0 0 1 k
/GS4 gs
(100)Tj
ET
/GS3 gs
288.055 173.924 m
119.186 173.924 l
S
BT
10 0 0 10 112.969 170.049 Tm
/GS4 gs
(0)Tj
ET
/GS3 gs
177.168 173.842 m
177.168 171.101 l
287.799 173.842 m
287.799 171.101 l
149.524 173.842 m
149.524 171.101 l
204.462 173.842 m
204.462 171.101 l
232.424 173.842 m
232.424 171.101 l
259.93 173.842 m
259.93 171.101 l
S
BT
/F22 1 Tf
6 0 0 6 242.926 264.322 Tm
/GS4 gs
(l)Tj
0.1848 -0.5437 TD
(l)Tj
0.3948 -0.9027 TD
(l)Tj
2.8102 0.5078 TD
(l)Tj
-0.4254 -0.9026 TD
(l)Tj
-4 0.4361 TD
(l)Tj
-0.0412 -0.9027 TD
(l)Tj
-0.1795 -1.1539 TD
(l)Tj
0.323 -0.4307 TD
(l)Tj
0.6461 -0.0053 TD
(l)Tj
1.118 0.6872 TD
(l)Tj
0.9385 -1.3692 TD
(l)Tj
1.5181 0.7232 TD
(l)Tj
0.8614 0.0359 TD
(l)Tj
-1.7918 -0.7232 TD
(l)Tj
-0.1077 -0.6461 TD
(l)Tj
-2.6442 0.323 TD
(l)Tj
0.0718 -0.682 TD
(l)Tj
0.9385 -0.8667 TD
(l)Tj
-2.5949 -1.3693 TD
(l)Tj
ET
0 0 0 0 k
3.864 M 
/GS3 gs
215.944 239.421 m
215.944 240.594 216.896 241.546 218.069 241.546 c
219.243 241.546 220.194 240.594 220.194 239.421 c
220.194 238.247 219.243 237.296 218.069 237.296 c
216.896 237.296 215.944 238.247 215.944 239.421 c
b
217.452 229.698 m
217.452 230.872 218.403 231.823 219.577 231.823 c
220.75 231.823 221.702 230.872 221.702 229.698 c
221.702 228.524 220.75 227.573 219.577 227.573 c
218.403 227.573 217.452 228.524 217.452 229.698 c
b
215.298 228.191 m
215.298 229.364 216.249 230.315 217.423 230.315 c
218.597 230.315 219.548 229.364 219.548 228.191 c
219.548 227.017 218.597 226.065 217.423 226.065 c
216.249 226.065 215.298 227.017 215.298 228.191 c
b
208.59 230.775 m
208.59 231.948 209.542 232.9 210.715 232.9 c
211.889 232.9 212.84 231.948 212.84 230.775 c
212.84 229.601 211.889 228.65 210.715 228.65 c
209.542 228.65 208.59 229.601 208.59 230.775 c
b
209.667 224.067 m
209.667 225.24 210.618 226.192 211.792 226.192 c
212.966 226.192 213.917 225.24 213.917 224.067 c
213.917 222.893 212.966 221.942 211.792 221.942 c
210.618 221.942 209.667 222.893 209.667 224.067 c
b
204.462 228.93 m
204.462 230.103 205.413 231.054 206.587 231.054 c
207.76 231.054 208.712 230.103 208.712 228.93 c
208.712 227.756 207.76 226.804 206.587 226.804 c
205.413 226.804 204.462 227.756 204.462 228.93 c
b
200.212 226.22 m
200.212 227.394 201.163 228.345 202.337 228.345 c
203.51 228.345 204.462 227.394 204.462 226.22 c
204.462 225.047 203.51 224.096 202.337 224.096 c
201.163 224.096 200.212 225.047 200.212 226.22 c
b
199.083 223.421 m
199.083 224.595 200.034 225.546 201.208 225.546 c
202.381 225.546 203.333 224.595 203.333 223.421 c
203.333 222.247 202.381 221.296 201.208 221.296 c
200.034 221.296 199.083 222.247 199.083 223.421 c
b
201.633 217.79 m
201.633 218.963 202.584 219.915 203.758 219.915 c
204.931 219.915 205.883 218.963 205.883 217.79 c
205.883 216.616 204.931 215.665 203.758 215.665 c
202.584 215.665 201.633 216.616 201.633 217.79 c
b
202.959 213.052 m
202.959 214.226 203.911 215.177 205.084 215.177 c
206.258 215.177 207.209 214.226 207.209 213.052 c
207.209 211.878 206.258 210.927 205.084 210.927 c
203.911 210.927 202.959 211.878 202.959 213.052 c
b
188.714 226.005 m
188.714 227.179 189.665 228.13 190.839 228.13 c
192.013 228.13 192.964 227.179 192.964 226.005 c
192.964 224.831 192.013 223.88 190.839 223.88 c
189.665 223.88 188.714 224.831 188.714 226.005 c
b
183.385 228.499 m
183.385 229.672 184.336 230.624 185.51 230.624 c
186.683 230.624 187.635 229.672 187.635 228.499 c
187.635 227.325 186.683 226.374 185.51 226.374 c
184.336 226.374 183.385 227.325 183.385 228.499 c
b
181.26 226.374 m
181.26 227.547 182.211 228.499 183.385 228.499 c
184.558 228.499 185.51 227.547 185.51 226.374 c
185.51 225.2 184.558 224.249 183.385 224.249 c
182.211 224.249 181.26 225.2 181.26 226.374 c
b
184.375 221.698 m
184.375 222.872 185.326 223.823 186.5 223.823 c
187.674 223.823 188.625 222.872 188.625 221.698 c
188.625 220.524 187.674 219.573 186.5 219.573 c
185.326 219.573 184.375 220.524 184.375 221.698 c
b
180.068 221.052 m
180.068 222.226 181.019 223.177 182.193 223.177 c
183.366 223.177 184.318 222.226 184.318 221.052 c
184.318 219.878 183.366 218.927 182.193 218.927 c
181.019 218.927 180.068 219.878 180.068 221.052 c
b
193.452 217.79 m
193.452 218.963 194.403 219.915 195.577 219.915 c
196.75 219.915 197.702 218.963 197.702 217.79 c
197.702 216.616 196.75 215.665 195.577 215.665 c
194.403 215.665 193.452 216.616 193.452 217.79 c
b
197.662 213.145 m
197.662 214.318 198.613 215.27 199.787 215.27 c
200.961 215.27 201.912 214.318 201.912 213.145 c
201.912 211.971 200.961 211.02 199.787 211.02 c
198.613 211.02 197.662 211.971 197.662 213.145 c
b
193.294 213.576 m
193.294 214.749 194.246 215.7 195.419 215.7 c
196.593 215.7 197.544 214.749 197.544 213.576 c
197.544 212.402 196.593 211.451 195.419 211.451 c
194.246 211.451 193.294 212.402 193.294 213.576 c
b
186.098 212.621 m
186.098 213.795 187.049 214.746 188.223 214.746 c
189.396 214.746 190.348 213.795 190.348 212.621 c
190.348 211.447 189.396 210.496 188.223 210.496 c
187.049 210.496 186.098 211.447 186.098 212.621 c
b
193.021 208.067 m
193.021 209.241 193.973 210.192 195.146 210.192 c
196.32 210.192 197.271 209.241 197.271 208.067 c
197.271 206.893 196.32 205.942 195.146 205.942 c
193.973 205.942 193.021 206.893 193.021 208.067 c
b
194.959 206.775 m
194.959 207.948 195.911 208.9 197.084 208.9 c
198.258 208.9 199.209 207.948 199.209 206.775 c
199.209 205.601 198.258 204.65 197.084 204.65 c
195.911 204.65 194.959 205.601 194.959 206.775 c
b
172.918 205.145 m
172.918 206.318 173.87 207.27 175.043 207.27 c
176.217 207.27 177.168 206.318 177.168 205.145 c
177.168 203.971 176.217 203.02 175.043 203.02 c
173.87 203.02 172.918 203.971 172.918 205.145 c
b
172.918 201.574 m
172.918 202.748 173.87 203.699 175.043 203.699 c
176.217 203.699 177.168 202.748 177.168 201.574 c
177.168 200.401 176.217 199.449 175.043 199.449 c
173.87 199.449 172.918 200.401 172.918 201.574 c
b
416.038 246.215 m
416.038 247.381 416.989 248.326 418.163 248.326 c
419.336 248.326 420.288 247.381 420.288 246.215 c
420.288 245.049 419.336 244.103 418.163 244.103 c
416.989 244.103 416.038 245.049 416.038 246.215 c
b
444.308 229.845 m
444.308 231.011 445.259 231.956 446.433 231.956 c
447.606 231.956 448.558 231.011 448.558 229.845 c
448.558 228.679 447.606 227.734 446.433 227.734 c
445.259 227.734 444.308 228.679 444.308 229.845 c
b
3.864 M 
341.469 302.174 m
341.469 171.205 l
341.733 301.984 m
338.992 301.984 l
341.733 258.547 m
338.992 258.547 l
341.733 237.092 m
338.992 237.092 l
341.733 215.709 m
338.992 215.709 l
341.733 194.835 m
338.992 194.835 l
S
BT
/F19 1 Tf
10 0 0 9.935 325.054 302.174 Tm
0 0 0 1 k
/GS4 gs
(b\))Tj
/F22 1 Tf
6 0 0 5.961 474.189 286.687 Tm
(l)Tj
2.1421 0.5954 TD
(l)Tj
ET
/GS3 gs
341.733 279.539 m
338.992 279.539 l
507.525 174.318 m
338.992 174.318 l
414.13 174.237 m
414.13 171.513 l
378.007 174.237 m
378.007 171.513 l
488.191 174.237 m
488.191 171.513 l
S
0 0 0 0 k
3.864 M 
463.957 226.774 m
463.957 227.94 464.908 228.885 466.081 228.885 c
467.255 228.885 468.206 227.94 468.206 226.774 c
468.206 225.608 467.255 224.663 466.081 224.663 c
464.908 224.663 463.957 225.608 463.957 226.774 c
b
456.991 228.661 m
456.991 229.827 457.942 230.772 459.116 230.772 c
460.29 230.772 461.241 229.827 461.241 228.661 c
461.241 227.495 460.29 226.55 459.116 226.55 c
457.942 226.55 456.991 227.495 456.991 228.661 c
b
452.061 207.132 m
452.061 208.298 453.012 209.243 454.185 209.243 c
455.359 209.243 456.311 208.298 456.311 207.132 c
456.311 205.966 455.359 205.021 454.185 205.021 c
453.012 205.021 452.061 205.966 452.061 207.132 c
b
3.864 M 
451.037 174.237 m
451.037 171.513 l
S
BT
6 0 0 5.961 483.332 264.261 Tm
0 0 0 1 k
/GS4 gs
(l)Tj
-1.81 -0.38 TD
(l)Tj
0.5561 -0.2383 TD
(l)Tj
-0.0316 -0.7543 TD
(l)Tj
-3.563 0.4595 TD
(l)Tj
1.9119 -0.4992 TD
(l)Tj
-1.2936 -0.3575 TD
(l)Tj
1.4922 -0.4766 TD
(l)Tj
-1.6114 -0.8567 TD
(l)Tj
-1.2539 -0.3403 TD
(l)Tj
0.0794 -0.4767 TD
(l)Tj
1.0553 0.1192 TD
(l)Tj
0.9136 0.0225 TD
(l)Tj
-4.7232 -0.7207 TD
(l)Tj
-0.6977 0.0795 TD
(l)Tj
-2.2073 0.7772 TD
(l)Tj
0.0794 -1.2142 TD
(l)Tj
1.1745 -0.4766 TD
(l)Tj
0.6752 0.2383 TD
(l)Tj
2.794 -1.231 TD
(l)Tj
-3.5405 -1.3333 TD
(l)Tj
ET
0 0 0 0 k
3.864 M 
/GS3 gs
451.037 213.949 m
451.037 215.115 451.989 216.06 453.162 216.06 c
454.336 216.06 455.287 215.115 455.287 213.949 c
455.287 212.783 454.336 211.838 453.162 211.838 c
451.989 211.838 451.037 212.783 451.037 213.949 c
b
441.468 224.738 m
441.468 225.904 442.419 226.85 443.593 226.85 c
444.766 226.85 445.717 225.904 445.717 224.738 c
445.717 223.572 444.766 222.627 443.593 222.627 c
442.419 222.627 441.468 223.572 441.468 224.738 c
b
436.962 225.59 m
436.962 226.756 437.913 227.701 439.087 227.701 c
440.26 227.701 441.212 226.756 441.212 225.59 c
441.212 224.424 440.26 223.479 439.087 223.479 c
437.913 223.479 436.962 224.424 436.962 225.59 c
b
436.485 229.276 m
436.485 230.442 437.436 231.387 438.61 231.387 c
439.784 231.387 440.735 230.442 440.735 229.276 c
440.735 228.11 439.784 227.165 438.61 227.165 c
437.436 227.165 436.485 228.11 436.485 229.276 c
b
429.043 227.477 m
429.043 228.643 429.994 229.588 431.168 229.588 c
432.341 229.588 433.293 228.643 433.293 227.477 c
433.293 226.311 432.341 225.366 431.168 225.366 c
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402.817 201.983 m
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402.817 206.205 m
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405.738 213.949 m
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389.812 231.17 m
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386.34 222.038 m
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[(ca)14.7(pn)21.2(ia)-243.3(is)-244.1(no)15.5(t)-253.5(i)0(n)18.8(f)0(r)18(e)0(q)15.1(u)0(e)20.8(n)0(t)-242.9([)0(2)13.9(2].)-253.9(It)-261.6(shoul)-7.4(d)-262.5(b)0(e)-263.7(point)-8.6(ed)-263.7(out)-260.7(that)]TJ
0 -1.0527 TD
[(the)-244.1(above)-243.6(five)-240.7(pati)-8.2(ents)-240.3(wer)-8.2(e)-240.2(neither)-245.8(obese)-244.8(nor)-237.2(h)-6.5(a)0(d)-235.2(h)-6.5(istory)]TJ
T*
[(of)-333.2(obstr)-9(uctive)-340.2(sleep)-338.2(apnoeas)-7.7(.)]TJ
1.0015 -1.0471 TD
[(Th)17.1(er)19.2(e)-280(w)0(a)16.9(s)-275.1(no)-269(si)17.7(gn)15.5(i)13.9(f)0(i)17.3(c)0(a)14.7(n)0(t)-265.7(d)0(i)13.2(f)20.4(fe)19.2(re)13.5(nc)20.8(e)-280(i)0(n)-265.7(b)0(r)19.6(e)0(a)14.7(t)0(h)18.9(i)0(n)18.9(g)-279.6(pa)20.8(tt)16.5(er)13.5(n)]TJ
-1.0015 -1.0528 TD
[(be)15.1(tw)20.6(ee)14.7(n)-484.5(t)0(h)18.9(e)-484.9(no)21.2(n-)13.9(F)11.4(L)-482.9(an)15.1(d)-484.5(F)11.4(L)-488.6(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)13.9(s.)-474.7(Ho)11.6(w)12.4(e)0(v)15.1(e)0(r)47.7(,)-484.1(in)-470.5(th)13.2(e)]TJ
0 -1.0471 TD
[(hy)15.5(pe)20.8(rc)13.5(ap)20.8(ni)18.9(c)-223.1(F)11.4(L)-221.1(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)17.7(,)]TJ
/F4 1 Tf
9.8105 0 TD
(V)Tj
/F3 1 Tf
7.97 0 0 7.97 161.972 646.129 Tm
(T)Tj
9.963 0 0 9.963 168.321 646.129 Tm
[(an)15.1(d)]TJ
/F4 1 Tf
1.6446 0 TD
(t)Tj
/F3 1 Tf
7.97 0 0 7.97 187.313 646.129 Tm
(I)Tj
9.963 0 0 9.963 192.076 646.129 Tm
[(we)16.9(re)-214.1(si)17.7(gn)21.2(if)17.3(ic)18.4(an)15.1(tl)16.5(y)-222.7(l)13.9(ow)11.6(er)]TJ
-13.4297 -1.0527 TD
[(th)18.9(an)-417.3(in)-413.6(th)18.9(e)-428(n)0(o)21.2(n)0(-)13.9(h)0(y)21.2(p)0(e)15.1(r)0(c)19.2(a)0(p)15.1(n)0(i)18.9(c)-422.3(FL)-420.3(pa)20.8(ti)16.5(en)15.1(t)13.9(s)0(.)-417.7(S)11.4(im)15.7(il)16.5(ar)-418.9(di)18.9(f)20.4(f)0(e)13.5(r)20.4(-)]TJ
0 -1.0471 TD
[(en)15.1(ce)20.4(s)-468.6(i)0(n)-453.5(t)0(h)18.9(e)-467.8(pa)15.1(tt)22.2(er)13.5(n)-461.7(o)0(f)-458.4(b)0(r)13.9(e)0(a)20.4(t)0(h)18.9(i)0(n)13.2(g)-461.7(ha)15.1(ve)-457.2(be)20.8(en)-457.2(pr)13.9(ev)20.8(io)18.9(us)14.4(ly)]TJ
0 -1.0527 TD
[(re)19.2(po)15.5(rt)17.3(ed)-428.7(by)-422.6(S)]TJ
6.974 0 0 6.974 114.406 614.721 Tm
0.0001 Tc
[(OR)18.4(LI)]TJ
/F4 1 Tf
9.963 0 0 9.963 134.702 614.721 Tm
0 Tc
[(et)-431.1(al)18.9(.)]TJ
/F3 1 Tf
2.5721 0 TD
[([2)13.9(3])-435.6(between)-456.7(hyperca)-8.2(pnic)-449.7(and)]TJ
-10.243 -1.0471 TD
[(non-hyp)-6.9(ercapni)-10.5(c)-371.1(COPD)-379(patients,)-379.8(the)-375(hyperca)-8.1(pnia)-375.7(being)]TJ
0 -1.0528 TD
[(attribut)-11.9(ed)-588.1(to)-590(increased)]TJ
/F4 1 Tf
10.0609 0 TD
(V)Tj
/F3 1 Tf
7.97 0 0 7.97 164.523 593.801 Tm
(D)Tj
9.963 0 0 9.963 170.249 593.801 Tm
(/)Tj
/F4 1 Tf
0.2675 0 TD
(V)Tj
/F3 1 Tf
7.97 0 0 7.97 178.979 593.801 Tm
(T)Tj
9.963 0 0 9.963 189.298 593.801 Tm
[(ratio)-596.7(with)-592.2(concom)-8.5(itant)]TJ
-13.1509 -1.0471 TD
[(reduct)-9.4(ion)-334.7(of)-333.2(alveol)-10.1(ar)-333.6(venti)-9(lation.)]TJ
/F4 1 Tf
0 -3.733 TD
[(Clinic)-11.1(al)-334(implicati)-11.7(ons)]TJ
/F3 1 Tf
1.0015 -2.0998 TD
[(Th)17.1(e)-228.8(h)0(i)18.9(g)0(h)-217.8(p)0(r)19.6(e)0(v)15.1(a)0(l)18.5(e)0(n)20.8(c)0(e)-218.6(o)0(f)-219.4(t)0(i)16.5(d)0(a)20.8(l)-225.1(FL)-221.1(at)-214.9(re)13.5(st)-215.6(wi)14.9(th)-214.5(co)15.1(nc)20.8(om)12.4(it)22.2(an)15.1(t)]TJ
-1.0015 -1.0471 TD
[(DH)-538.6(in)-533.1(CO)18.3(PD)-539.6(pa)20.8(ti)16.5(en)15.1(ts)17.7(,)-541(p)0(r)14(o)0(m)18.1(o)0(t)18.9(e)0(s)-532.3(i)0(n)13.2(c)0(r)19.2(e)0(a)14.7(s)0(e)19.6(d)-541.4(in)13.2(sp)20(ir)17.3(at)18.4(or)13.9(y)]TJ
0 -1.0527 TD
[(wo)17.3(rk)-526.7(du)15.5(e)-536.1(t)0(o)-527.4(i)0(n)18.9(t)0(r)17.3(i)0(n)18.9(s)0(i)17.7(c)-536.1(po)15.5(si)17.7(ti)16.5(ve)-525.5(en)15.1(d)-535.7(e)0(x)20.8(p)0(i)13.2(r)0(a)19.2(t)0(o)18.8(r)0(y)-526.7(p)0(r)13.9(e)0(s)19.6(s)0(u)14.4(r)0(e)]TJ
0 -1.0471 TD
[(\(P)14.7(E)12.2(E)0(P)17.9(i)0(\))17.3(,)-478.4(im)15.7(pa)20.8(ir)17.3(ed)-468.6(in)18.9(sp)20(ir)11.6(at)18.4(or)19.6(y)-478.8(m)13.2(us)14.4(cl)18.4(e)-473.5(f)0(u)13.9(n)0(c)20.8(t)0(i)16.5(o)0(n)15.5(,)-472.7(an)15.1(d)-473.1(a)0(d)15.1(-)]TJ
0 -1.0527 TD
[(ve)15.1(rs)18.4(e)-262.9(e)0(f)24.9(f)0(e)19.2(c)0(t)18.5(s)-269.4(on)-257.6(ha)20.8(em)17.7(od)15.5(yn)15.5(am)17.7(ic)18.4(s)-263.7([)0(2)13.9(4].)-265.3(Increas)-10.9(ed)-275.1(FRC)-284.1(due)]TJ
0 -1.0471 TD
[(to)-578.7(dynam)-7.4(ic)-573.4(h)-6.5(yperinflation)-586.8(is)-579.8(axiomati)-11.5(cally)-578.4(associ)-10.1(ated)]TJ
0 -1.0528 TD
[(with)-233.7(decreas)-9.7(ed)-235.2(IC.)-230.2(Bec)-7.8(ause)-232.7(of)-230.7(tidal)-233.3(FL,)]TJ
/F4 1 Tf
15.8083 0 TD
(V)Tj
/F3 1 Tf
7.97 0 0 7.97 221.839 462.501 Tm
0.0001 Tc
(Tmax)Tj
9.963 0 0 9.963 242.476 462.501 Tm
0 Tc
[(\(and)-232.7(h)-6.5(ence)]TJ
-18.4886 -1.0471 TD
[(maximal)-233.4(exerci)-9.8(se\))-227.4(is)-227(closely)-228.3(relat)-11(ed)-223.9(to)-225.8(resting)-229.5(IC)-229.8([8].)-227.8(This)]TJ
0 -1.0528 TD
[(provi)-7.8(des)-499(a)-496.2(reason)-8.2(able)-501.3(mecha)-8.2(nistic)-502.7(explan)-7.8(atio)-8.2(n)-495.8(for)-500.6(the)]TJ
0 -1.0471 TD
[(close)-372.4(associ)-10.1(ation)-373.2(between)-377.1(resting)-377.5(IC)-366.3(an)-7.6(d)-365(exerci)-9.8(se)-367.3(tole)-8.2(r-)]TJ
0 -1.0527 TD
[(ance)-351.4(in)-345.3(FL)-346.3(pati)-8.2(ents.)-348.8(Assessm)-11.9(ent)-346.5(of)-350.2(IC)-349.3(has)-345.3(alrea)-9(dy)-348.7(been)]TJ
0 -1.0471 TD
[(shown)-458.5(to)-459.2(provi)-7.8(de)-457.2(useful)-459.7(infor)-9.4(mation)-462.4(on)-456.8(the)-454.6(effects)-457.2(of)]TJ
0 -1.0528 TD
[(surgical)-663.2(treatmen)-11.1(t)-663.2([25])-672(and)-668.5(broncho)-7.3(dilators)-670.8([26])-672(on)]TJ
0 -1.0471 TD
[(hyperi)-9(nflation)-470.5(in)-464.8(COPD)-470.1(pati)-8.2(ents.)-468.3(Recentl)-10.3(y)61.8(,)-461.3(it)-467.2(has)-464.8(also)]TJ
0 -1.0528 TD
[(been)-237.2(shown)-236.6(that)-235.8(in)-231.5(COP)-10.2(D)-232.3(patients)-237.2(the)-238.4(increase)-240.5(in)-231.5(IC)-235.5(after)]TJ
0 -1.0471 TD
[(antich)-10.1(olinergic)-392(thera)-8.6(py)-394.2(best)-399.7(reflected)-403.4(the)-397.7(improvem)-11.1(ents)]TJ
0 -1.0528 TD
[(in)-334(exerci)-9.8(se)-333.2(enduran)-7.7(ce)-338.1(and)-338.4(dyspnoe)-6.9(a)-331.2([27].)]TJ
1.0015 -1.0471 TD
[(As)16.1(se)19.6(ss)13.2(me)17.7(nt)-311.2(of)-316.1(F)11.4(L)-323.6(ma)17.7(y)-325.1(a)0(l)18.4(s)0(o)-315.7(p)0(r)19.6(o)0(v)15.5(i)0(d)18.9(e)-319.8(a)-325.5(u)0(s)20(e)0(f)13.5(u)0(l)-311.2(g)0(u)15.5(i)0(d)18.9(e)-319.8(fo)13.9(r)]TJ
-1.0015 -1.0527 TD
[(re)19.2(ha)15.1(bi)18.9(li)16.5(ta)18.4(ti)16.5(on)-399.9(in)-402.2(C)11.6(O)0(P)12.4(D)-408.7(pa)15.1(t)13.9(i)0(e)12.8(n)0(t)18.9(s)0(:)-397.7(i)0(n)-402.3(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-403.4(w)12.4(it)16.5(ho)15.5(ut)-402.2(F)11.4(L)0(,)]TJ
0 -1.0471 TD
[(re)19.2(ha)15.1(bi)18.9(li)16.5(ta)18.4(ti)16.5(on)-217.8(ba)20.8(se)13.9(d)-222.7(o)0(n)-212.1(e)0(x)15.1(e)0(r)19.2(c)0(i)18.4(s)0(e)-219.4(s)0(h)20(o)0(u)15.5(l)0(d)-214.5(b)0(e)-212.5(p)0(a)15.1(r)0(t)17.3(i)0(c)18.4(u)0(l)18.9(a)0(r)13.5(l)0(y)-214.5(b)0(e)15.1(n)0(-)]TJ
0 -1.0528 TD
[(ef)19.2(ic)12.8(ia)18.4(l,)-345(wh)17.3(il)16.5(e)-354(i)0(n)-351(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)-346.5(w)12.4(it)16.5(h)-359.3(F)11.4(L)-357.7(a)0(d)20.8(m)0(i)15.7(n)0(i)13.2(s)0(t)17.7(r)0(a)19.2(t)0(i)16.5(o)0(n)-343(o)0(f)-350.2(b)0(r)19.6(o)0(n)15.5(-)]TJ
T*
[(ch)15.1(od)21.2(il)16.5(at)18.5(or)13.9(s)-593.8(a)0(n)15.1(d)-598.3(in)18.9(sp)20(ir)17.3(at)18.4(or)13.9(y)-598.3(m)0(u)18.1(s)0(c)19.6(l)0(e)-590.4(t)0(r)17.3(a)0(i)18.4(n)0(i)13.2(n)0(g)-587.7(s)0(h)20(o)0(u)15.5(l)13.9(d)-598.3(b)0(e)]TJ
0 -1.0471 TD
[(pr)19.6(ef)13.5(er)19.2(ab)15.1(le)-186.4(in)-191.7(or)13.9(de)20.8(r)-201.5(t)0(o)-186(d)0(e)15.1(c)0(r)19.2(e)0(a)14.7(s)0(e)-190.9(t)0(h)18.9(e)-200.3(pr)19.6(ev)15.1(ai)18.5(li)16.5(ng)-189.3(hy)21.2(pe)15.1(ri)17.3(nf)19.6(la)12.8(t)13.9(i)0(o)13.2(n)]TJ
0 -1.0528 TD
[([2)19.6(6,)-308.4(27])-316.9(and)-315.7(to)-316.9(increa)-9.8(se)-316.1(the)-312.4(wor)-7.8(king)-318.4(capaci)-8.6(ty)-311.2(of)-316.1(the)-318.1(ins-)]TJ
0 -1.0471 TD
[(piratory)-344.5(muscles)-338.4([28,)-340(29].)]TJ
1.0015 -1.0527 TD
[(In)-344.6(co)20.8(nc)15.1(lu)18.9(si)17.7(on)15.5(,)-347.5(t)0(h)13.2(e)-348.3(pr)13.9(es)19.6(en)15.1(t)-350.3(r)0(e)19.2(s)0(u)14.3(l)0(t)16.5(s)-349.1(sh)14.4(ow)-341.2(th)18.9(at)-345.7(in)-339.7(ch)15.1(ro)19.6(ni)13.2(c)]TJ
-1.0015 -1.0471 TD
[(ob)15.5(st)17.7(ru)19.6(ct)18.5(iv)18.8(e)-496.2(p)0(u)21.2(l)0(m)15.7(o)0(n)15.5(a)0(r)19.2(y)-495.8(di)18.9(se)19.6(as)13.9(e)-490.6(p)0(a)15.1(t)0(i)16.5(e)0(n)20.8(t)0(s)-483.1(t)0(h)13.2(e)0(r)19.2(e)-490.6(is)-488.8(a)-490.6(c)0(l)18.4(o)0(s)14.4(e)]TJ
0 -1.0528 TD
[(as)19.6(so)14.3(ci)18.4(at)18.4(io)18.9(n)-251.2(o)0(f)-236.4(e)0(x)20.8(e)0(r)13.5(c)0(i)18.4(s)0(e)-236.4(t)0(o)18.9(l)0(e)12.8(r)0(a)19.2(n)0(c)15.1(e)-245.9(to)-237.2(re)19.2(st)17.7(in)18.9(g)-251.2(i)0(n)18.8(s)0(p)20(i)0(r)17.3(a)0(t)18.4(o)0(r)14(y)-245.5(ca)14.7(p-)]TJ
0 -1.0471 TD
[(ac)14.7(i)13.9(t)0(y)-373.8(i)0(n)-373.8(f)0(l)17.3(o)0(w)-375.3(l)0(i)16.5(m)0(i)15.7(t)0(e)18.4(d)-382(pa)20.8(ti)16.5(en)15.1(ts)17.7(.)-381.7(A)-380.3(re)13.5(du)21.2(ct)18.4(io)13.2(n)-382(i)13.9(n)-382(i)0(n)13.2(s)0(p)20(i)0(r)17.3(a)0(t)18.4(o)0(r)13.9(y)]TJ
0 -1.0528 TD
[(ca)14.7(pa)20.8(ci)18.4(ty)75.8(,)-353.2(r)0(e)13.5(f)0(l)17.3(e)0(c)20.4(t)0(i)16.5(n)0(g)-348.7(d)0(y)21.2(n)0(a)15.1(m)0(i)15.7(c)-354(hy)15.5(pe)15.1(ri)17.3(nf)19.6(la)18.4(ti)16.5(on)-348.7(an)20.8(d)-359.3(i)0(n)18.9(c)0(r)13.5(e)0(a)20.4(s)0(e)13.9(d)]TJ
0 -1.0471 TD
[(in)18.9(tr)17.3(in)18.9(si)12(c)-262.9(p)0(o)15.5(s)0(i)17.7(t)0(i)16.5(v)0(e)-258(e)0(n)15.1(d)-268.2(ex)20.8(pi)18.9(ra)13.5(to)18.9(ry)-259.2(pr)19.6(es)13.9(su)20(re)13.5(,)-267.8(a)0(l)18.5(s)0(o)-258.8(p)0(l)18.9(a)0(y)15.1(s)-263.7(a)-268.6(r)0(o)14(l)0(e)]TJ
0 -1.0527 TD
[(in)-464.8(de)20.8(te)18.4(rm)16.5(in)13.2(i)13.9(n)0(g)-462.5(h)0(y)15.5(p)0(e)20.8(r)0(c)13.5(a)0(p)20.8(n)0(i)13.2(a)-467.8(in)-464.8(th)18.9(e)-467.8(s)0(a)13.9(m)0(e)-460.3(g)0(r)13.9(o)0(u)21.2(p)-473.1(of)-452.7(fl)17.3(ow)]TJ
0 -1.0471 TD
[(li)16.5(mi)15.7(te)18.4(d)-325.1(p)0(a)20.8(t)0(i)16.5(e)0(n)15.1(t)0(s)17.7(.)]TJ
/F6 1 Tf
8.966 0 0 8.966 151.257 158.343 Tm
[(Referenc)8.7(es)]TJ
/F3 1 Tf
-10.3696 -2.8896 TD
[(1.)-1766.5(Gilbert)-557.7(R,)-563.5(Keighley)-559.9(J,)-560(Auchincloss)-567.1(JH.)-556.5(Disability)-567.5(in)]TJ
2.5165 -1.1065 TD
[(patients)-566.5(with)-562.5(obstructive)-572.3(pulmonary)-563.1(disease.)]TJ
/F4 1 Tf
19.4493 0 TD
[(Am)-568.5(Rev)]TJ
-19.4493 -1.1128 TD
[(Respir)-333.8(Dis)]TJ
/F3 1 Tf
4.622 0 TD
[(1964;)-334.9(90:)-329.6(383\261394.)]TJ
20.8593 73.5671 TD
[(2.)-1766.5(Jones)-309.4(NL,)-305.8(Jones)-303.1(G,)-309.2(Edwards)-308.6(RHT)72.2(.)-306.4(Exercise)-306.8(tolerance)-310.1(in)]TJ
2.5165 -1.1191 TD
[(chronic)-492.5(airway)-490(obstruction.)]TJ
/F4 1 Tf
11.8302 0 TD
[(Am)-492.7(Rev)-488.4(Respir)-491.8(Dis)]TJ
/F3 1 Tf
8.7193 0 TD
(1971;)Tj
-20.5495 -1.1128 TD
[(103:)-335.5(477\261491.)]TJ
-2.5165 -1.1128 TD
[(3.)-1766.5(Carlson)-410.1(DJ,)-411(Ries)-410.7(AL,)-413.3(Kaplan)-406.8(RM.)-411.9(Predicting)-412.1(maximal)]TJ
2.5165 -1.1128 TD
[(exercise)-423.2(tolerance)-423.9(in)-418.7(patients)-421.1(with)-423.4(COPD.)]TJ
/F4 1 Tf
17.8685 0 TD
(Chest)Tj
/F3 1 Tf
2.6809 0 TD
(1991;)Tj
-20.5495 -1.1192 TD
[(100:)-335.5(307\26131)34.7(1.)]TJ
-2.5165 -1.1128 TD
[(4.)-1766.5(Murariu)-254.1(C,)-247.4(Ghezo)-253.2(H,)-252.3(Milic-Emili)-255.7(J,)-250.2(Gauthier)-251.1(H.)-252.3(Exercise)]TJ
2.5165 -1.1128 TD
[(limitation)-390.2(in)-380.8(obstructive)-388.9(lung)-379.7(disease.)]TJ
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