TY -的T1的诞生一个新的肺综合症?JF - European Respiratory Journal JO - Eur Respir J SP - 1886 LP - 1888 DO - 10.1183/13993003.00155-2016 VL - 47 IS - 6 AU - Quanjer, Philip H. Y1 - 2016/06/01 UR - //www.qdcxjkg.com/content/47/6/1886.abstract N2 - In a recent issue of the European Respiratory Journal, Harvey et al. [1] measured spirometry and transfer factor on two occasions in 105 smokers (74% African-Americans). Throughout the study, there was no evidence of respiratory disease. Whilst all had a forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio >0.7, in 46, the measured transfer factor of the lung for carbon monoxide (TLCO) was <80% predicted. In 15 out of 59 subjects with normal values, TLCO fell below 80% predicted during follow-up; in two, the FEV1/FVC ratio declined slightly below 0.7. Of the 46 subjects with TLCO <80% predicted, the FEV1/FVC ratio declined to <0.7. The authors conclude that a normal-spirometry, low-TLCO phenotype is a risk factor for developing chronic obstructive pulmonary disease. However, there are several flaws in this study that invalidate the conclusion.The proposal of a normal-spirometry, high-TLCO phenotype that predisposes to airway obstruction has several flaws http://ow.ly/XRmz2 ER -