TY -的T1 -当胰岛素ke努力工作ep the sugar at bay the upper airway collapses away JF - European Respiratory Journal JO - Eur Respir J SP - 1611 LP - 1614 DO - 10.1183/13993003.00590-2016 VL - 47 IS - 6 AU - Eckert, Danny J. AU - Oliven, Arie Y1 - 2016/06/01 UR - //www.qdcxjkg.com/content/47/6/1611.abstract N2 - Obesity is a major risk factor for both obstructive sleep apnoea (OSA) and metabolic disease. As obesity rates continue to rise, so too does the prevalence of OSA and metabolic disorders. Indeed, recent community sample data from over 2000 adults aged 40–85 years in Switzerland indicate that up to 50% of men and almost a quarter of women have apnoea–hypopnoea indices (AHI) within the moderate to severe range (>15 events·h−1 sleep) [1]. Insulin resistance, a strong predictor for the development of type 2 diabetes [2], is being recognised earlier with prevalence rates in children varying between 3 and 44% [3]. Thus, OSA and insulin resistance are major health issues.Insulin resistance may increase upper airway collapsibility and directly contribute to sleep apnoea pathogenesis http://ow.ly/10BTf9 ER -