TY - T1的接触强度肺结核结核感染和疾病的风险决定JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01578 -2017欧元六世- 51 - 1 SP - 1701578 AU Acuna-Villaorduna卡洛斯盟——Jones-Lopez Edward c . AU - Fregona盖萨盟——Marques-Rodrigues,帕特丽夏盟,Gaeddert玛丽AU - geada的解释,卡非盟-哈达,大卫·贾米尔AU -白色,劳拉·f . AU -佩雷拉南美洲莫利纳Lucilia盟——vinha却抹胸盟——Ribeiro-Rodrigues罗德里戈盟——Salgame Padmini盟——Palaci莫伊塞斯盟——Alland大卫盟——Ellner·J . AU - Dietze Reynaldo Y1 - 2018/01/01 UR - //www.qdcxjkg.com/content/51/1/1701578.abstract N2 -家庭接触者的肺结核(TB)患者结核感染和疾病的风险增加。然而,风险与曝光强度仍然未知。我们研究痰检阳性结核病例和他们的家庭接触者在维多利亚,巴西。我们收集临床、人口从结核病例和影像学信息,和获得结核菌素皮肤试验(TST)和QuantiFERON-TB黄金从家庭接触者(QFT)结果。我们测量接触使用强度接近得分和睡眠位置关系定义的结核病索引病例和感染结核菌素≥10毫米或QFT≥0.35 UI·毫升−1。我们确定次生结核病例通过回顾本地和全国注册。我们包括160名结核病索引病例和894家庭接触者。464例(65%)有结核感染和23(2.6%)开发结核病。结核感染和疾病的风险增加有强烈的风险敞口。的调整分析,接近得分与结核病有关(或1.61,95%可信区间1.25 - -2.08;术中,0.000); however, its diagnostic performance was only moderate.Intensity of exposure increased risk of TB infection and disease among household contacts; however, its diagnostic performance was still suboptimal. A biomarker to target preventive therapy is urgently needed in this at-risk population.More intense exposures are associated with higher risk of TB infection and disease among close contacts of TB cases http://ow.ly/PnQW30gapxK ER -