TY - T1的暴露于肺的强度tuberculosis determines risk of tuberculosis infection and disease JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01578-2017 VL - 51 IS - 1 SP - 1701578 AU - Acuña-Villaorduña, Carlos AU - Jones-López, Edward C. AU - Fregona, Geisa AU - Marques-Rodrigues, Patricia AU - Gaeddert, Mary AU - Geadas, Carolina AU - Hadad, David Jamil AU - White, Laura F. AU - Pereira Dutra Molina, Lucilia AU - Vinhas, Solange AU - Ribeiro-Rodrigues, Rodrigo AU - Salgame, Padmini AU - Palaci, Moises AU - Alland, David AU - Ellner, Jerrold J. AU - Dietze, Reynaldo Y1 - 2018/01/01 UR - //www.qdcxjkg.com/content/51/1/1701578.abstract N2 - Household contacts of pulmonary tuberculosis (TB) patients are at increased risk of TB infection and disease. However, their risk in relation to the intensity of exposure remains unknown.We studied smear-positive TB cases and their household contacts in Vitória, Brazil. We collected clinical, demographic and radiographic information from TB cases, and obtained tuberculin skin test (TST) and QuantiFERON-TB Gold (QFT) results from household contacts. We measured intensity of exposure using a proximity score and sleep location in relation to the TB index case and defined infection by TST ≥10 mm or QFT ≥0.35 UI·mL−1. We ascertained secondary TB cases by reviewing local and nationwide case registries.We included 160 TB index cases and 894 household contacts. 464 (65%) had TB infection and 23 (2.6%) developed TB disease. Risk of TB infection and disease increased with more intense exposures. In an adjusted analysis, the proximity score was associated with TB disease (OR 1.61, 95% CI 1.25–2.08; p<0.000); however, its diagnostic performance was only moderate.Intensity of exposure increased risk of TB infection and disease among household contacts; however, its diagnostic performance was still suboptimal. A biomarker to target preventive therapy is urgently needed in this at-risk population.More intense exposures are associated with higher risk of TB infection and disease among close contacts of TB cases http://ow.ly/PnQW30gapxK ER -