@Article {Raymakers1801257，作者= {Raymakers，Adam J.N.以及Sadatsafavi，Mohsen和Sin，Don D.和Fitzgerald，J。Mark和Marra，Carlo A.和Lynd，Larry D.}，Title = {copd中的copticoltoids and copd中的肺癌风险：一项基于人群的队列研究。188bet官网地址皮质类固醇（ICS）通常在患有慢性阻塞性肺疾病（COPD）的患者中处方。他们对COPD患者死亡的主要原因的影响仍然不确定。从1997年至2007年，加拿大不列颠哥伦比亚省的基于人口的链接行政数据仍不确定。COPD患者的癌症风险和ICS使用。根据在受试者中收到三个与COPD相关的处方> = 50岁的情况下，定义了COPD。使用多种时间依赖的方法（{\ texquotedblleft} ever {\ textquotedblright}暴露，使用累积剂量，累积剂量，加权累积的使用时间和加权累积剂量），使用了几种时间依赖的方法（{\ texquotedblleft}将接触ICS的暴露纳入多变量COX回归模型。 676 patients who met the inclusion criteria. The mean{\textpm}sd age of the cohort was 70.7{\textpm}11.1 years and 53\% were female. There were 994 (2.5\%) cases of lung cancer during follow-up. In the reference case analysis (time-dependent {\textquotedblleft}ever{\textquotedblright} exposure), ICS exposure was associated with a 30\% reduced risk of lung cancer (HR 0.70 (95\% CI 0.61{\textendash}0.80)). ICS exposure was associated with a decrease in the risk of lung cancer diagnosis over all five methods of quantifying exposure.This population-based study suggests that ICS use reduces the risk of lung cancer in COPD patients.Inhaled corticosteroid use appears to reduce the risk of lung cancer in a population-based cohort of COPD patients http://ow.ly/UuDZ30o7Bdi}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/53/6/1801257}, eprint = {//www.qdcxjkg.com/content/53/6/1801257.full.pdf}, journal = {European Respiratory Journal} }