TY -的T1 Morphomolecular图案的肺间质性肺疾病neoangiogenesis JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00933 -2019欧元六世- 55 - 3 SP - 1900933 AU -阿克曼,马克西米利安非盟-斯塔克,Helge盟——Neubert拉维尼娅AU -舒伯特,斯蒂芬妮盟——Borchert保罗AU -林茨,Friedemann AU - Wagner, Willi L. AU - Stiller, Wolfram AU - Wielpütz, Mark AU - Hoefer, Anne AU - Haverich, Axel AU - Mentzer, Steven J. AU - Shah, Harshit R. AU - Welte, Tobias AU - Kuehnel, Mark AU - Jonigk，Danny Y1 - 2020/03/01 UR - //www.qdcxjkg.com/content/55/3/1900933.abstract N2 -血管生成在间质性肺病(ILDs)中的致病作用是有争议的。本研究首次对人类ILD重要亚群微血管结构的空间复杂性和分子基础进行了研究。我们研究的目的是在人类ILD的三种常见肺损伤模式中识别特定的新血管生成变异。我们对24例常见间质性肺炎(UIP)、非特异性间质性肺炎(NSIP)和肺泡纤维弹性变性(AFE)的人肺外植体进行了全面和室特异性分析，使用组织病理学、微血管腐蚀铸型、基于微计算机断层扫描的体积测量和基因表达分析，使用纳米线和免疫组化来评估重构相关的血管生成。血管直径和血管间距离的形态学评估显示，UIP、NSIP和AFE肺特征性重塑区域的新血管生成有显著差异。同样，基因表达分析显示UIP、NSIP和AFE肺中不同和特异的血管生成谱。UIP肺显示上游血管密度较高，病灶周围血管密度较低，NSIP和AFE肺显示密集的肺泡间隔血管。 Vascular remodelling in NSIP and AFE is characterised by a prominent intussusceptive neoangiogenesis, in contrast to UIP, in which sprouting of new vessels into the fibrotic areas is characteristic. The molecular analyses of the gene expression provide a foundation for understanding these fundamental differences between AFE and UIP and give insight into the cellular functions involved.Pulmonary injury patterns are the common denominator in progression of fibrosing lung diseases. This study identified distinct manifestations of neoangiogenesis as drivers of pulmonary remodelling in human ILDs, modulated by bone marrow-derived monocytes. http://bit.ly/34F7KNS ER -