TY - JOUR T1 -吸入阿曲霉素改善支气管扩张患者的咳嗽和产痰症状:< em >事后< / em > AIR-BX分析研究摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.00608 -2020欧元六世- 56 - 1 SP - 2000608 AU -克莱顿,梅根·l . AU -》,迈克盟——巴克,艾伦·f . AU - Sibila Oriol盟——Goeminne Pieter AU - Shoemark,阿米莉亚AU -查尔默斯,吸入抗生素可改善症状评分，但目前尚不清楚哪些具体症状会随着治疗而改善。问卷数据的项目级分析可以让我们确定哪些具体症状对治疗反应最好。方法回顾性分析AIR-BX1研究和两个吸入阿曲南与安慰剂治疗支气管扩张的临床试验。从支气管扩张症(QOL-B)呼吸症状量表中提取个别项目，代表9种不同症状的严重程度。使用广义线性模型来评估治疗组与安慰剂组从基线到第一个治疗周期结束期间的症状变化，使用混合模型来评估整个16周试验的变化。结果阿曲南改善咳嗽(差异0.22,95% CI 0.08-0.37;p=0.002)、痰产量(0.30,95% CI 0.15 ~ 0.44;0.0001)和痰颜色(0.29,95% CI 0.15-0.43;与安慰剂相比，咳嗽症状改善了20%，痰量和颜色改善了25%。 Similar results were observed for cough, sputum production and sputum purulence across the trial duration (all p<0.05). Patients with higher sputum production and sputum colour scores had a greater response on the overall QOL-B (difference 4.82, 95% CI 1.12–8.53; p=0.011 for sputum production and 5.02, 95% CI 1.19–8.86; p=0.01 for sputum colour). In contrast, treating patients who had lower levels of bronchitic symptoms resulted in shorter time to next exacerbation (hazard ratio 1.83, 95% CI 1.02–3.28; p=0.042).Conclusion Baseline bronchitic symptoms predict response to inhaled aztreonam in bronchiectasis. More sensitive tools to measure bronchitic symptoms may be useful to better identify inhaled antibiotic responders and to evaluate patient response to treatment.Inhaled aztreonam improves cough and sputum production in patients with bronchiectasis but has no impact on other symptoms. More sensitive tools to measure bronchitic symptoms may be useful to enrich for responders and to evaluate patient benefit. https://bit.ly/2UMKM5i ER -