％0期刊文章％lee，sanghun％a lasky-su，jessica ann％a lange，christoph％akim，wonji％a kumar，preeti lakshman％a麦克唐纳，梅花 - 林恩。％a laurie，cecelia％a raby，benjamin A.％aceledón，juan C.％cho，迈克尔·H·％a won，sungho％a weiss，scott a weiss，scott t.％hecker a hecker，julian％t a a a a a n a a n a News locus for inthe n for劳累性肿瘤在儿童哮喘中％D 2020％R 10.1183/13993003.01224-2020％J欧洲呼吸期刊％p 2001224％x背景大多数被诊断出患有哮喘的儿童患有呼吸道症状，例如咳嗽，呼吸困难和喘息，这也是整体呼吸器功能的重要标志。十年的全基因组关联研究（GWAS）研究了哮喘诊断本身的遗传敏感性，但很少有人专注于重要的呼吸道症状，这些呼吸症状是童年哮喘特征的特征，使用全基因组测序（WGS）数据，用于894哮喘三重量表。哥斯达黎加队列，我们​​进行了基于家庭的关联测试（FBAT），以评估遗传变异与多个与哮喘相关的呼吸表型之间的关联：咳嗽，痰，喘息，喘息，劳累性呼吸困难和胸部紧绷。我们测试了整个基因组的重要关联是否在另外两项研究中复制：1）来自儿童哮喘管理计划（CAMP）的286个WGS三重奏，以及2）2691年非裔美国人（AA）现任或前吸烟者或前吸烟者。894 Costa Rican Trios，我们确定了全基因组呼吸困难与单核苷酸多态性（SNP）RS10165869之间的显着关联，位于染色体2q37.3上，P值为P = 3.49×10-9（P = p = 3.49×10-9）0.0222）具有相同的缔合方向（合并P = 5.54×10-10），但在COPDGENE的AA受试者中无关。我们还发现了SNP RS10165869与非典型趋化因子受体3（ACKR3）之间的联系的暗示性证据，以进行生物学解释。判定我们确定并复制了劳累性呼吸困难和SNP RS10165869之间的新型关联，以鼓励发现呼吸道呼吸症状的呼吸型杂质群群综合症。在各种气道疾病中，Footnotesthis手稿最近在欧洲呼吸道杂志上被接受。它在我们的生产团队复制和排版之前以其公认的形式出版。 After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Lee has nothing to disclose.Conflict of interest: Dr Lasky-Su has nothing to disclose.Conflict of interest: Dr Lange has nothing to disclose.Conflict of interest: Dr Kim has nothing to disclose.Conflict of interest: Dr Kumar has nothing to disclose.Conflict of interest: Dr. McDonald has nothing to disclose.Conflict of interest: Dr. Vaz Fragoso has nothing to disclose.Conflict of interest: Dr Laurie has nothing to disclose.Conflict of interest: Dr Raby has nothing to disclose.Conflict of interest: Dr. Celedon has received research materials from GSK and Merck (inhaled steroids) and Pharmavite (vitamin D and placebo capsules), in order to provide medications free of cost to participants in NIH-funded studies, unrelated to the current work.Conflict of interest: Dr Cho has nothing to disclose.Conflict of interest: Dr Won has nothing to disclose.Conflict of interest: Dr. Weiss reports that he is an author for UpToDate, PI of several NIH grants and an unpaid advisor to Novartis Pharmaceuticals.Conflict of interest: Dr. Hecker has nothing to disclose. %U //www.qdcxjkg.com/content/erj/early/2020/08/06/13993003.01224-2020.full.pdf