TY - JOUR T1 -寒冷频率的风险因性别而异:哮喘的作用、年龄、TLR7和白细胞子集JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02453 -2019欧元六世- 56 - 4 SP - 1902453 AU -穆雷,Liisa m . AU - Yerkovich斯蒂芬妮·t . AU -费雷拉,曼努埃尔·a . AU -阿帕姆,病毒性呼吸道感染通常是良性的，但可以引发哮喘恶化。与上呼吸道感染(感冒)频率相关的因素尚不完全了解，也不清楚这些因素在女性和男性之间是否有差异。为了确定哪些免疫学和临床变量与自我报告的呼吸道感染(感冒)频率相关，我们招募了150例哮喘患者和151例对照组。抗病毒免疫反应变量之间的关系:toll样受体(TLR)7/8基因表达，浆细胞样树突状细胞(pDC)数量和干扰素-α，肿瘤坏死因子和白细胞介素-12的产生，以及哮喘，然后检查可能解释寒冷频率。哮喘患者每年报告的感冒次数更多(中位数为3比2;p<0.001)，且TLR7基因的基线表达较低(优势比0.12;比控制p = 0.02)。许多变量和寒冷频率之间的关联在女性和男性之间是不同的。在女性中，较高的血液中性粒细胞计数(β=0.096, p=0.002)和较年轻的年龄(β=−0.017,p<0.001)，但没有接触儿童，独立地与更频繁的感冒有关。 In men, low TLR7 expression (β=−0.96, p=0.041) and high CLEC4C gene expression (a marker of pDC; β=0.88, p=0.008) were independently associated with more frequent colds. Poor asthma symptom control was independently associated with reduced TLR8 gene expression (β=−1.4, p=0.036) and high body mass index (β=0.041, p=0.004).Asthma, age and markers of inflammation and antiviral immunity in peripheral blood are associated with frequent colds. Interestingly, the variables associated with cold frequency differed between women and men.Asthma, age and blood markers of antiviral immunity associate with cold frequency in a sex-dependent manner. People with asthma have lower TLR7 gene expression than healthy people; only in men does this associate with cold frequency. https://bit.ly/3e3yWKy ER -