％0刊杂志百分之一，Bettina S.％A Binggeli，Severin％A yammine，Sophie％A Spycycher，Ben％AKrüger，Linn％A Ramsey，Kathryn A.％A Latzin，Philipp％T纵向肺部肺炎囊性纤维化的儿童的许可指数％D 2020％R 10.1183 / 13993003.02686-2020％J欧洲呼吸期轴颈％p 2002686％x基本原理，而肺部间隙指数（LCI）是囊性纤维化的个体中小气道病的敏感标记（CF），较少是常规临床监测期间LCI中纵向变化的较少。目的，在常规临床监测中描述CF儿童LCI的纵向过程，评估影响因素。患有3-18岁的CF的儿童每3次进行LCI测量 months as part of routine clinical care between 2011 and 2018. We recorded clinical data at every visit. We used a multilevel mixed-effect model to determine changes in LCI over time and identify clinical factors that influence LCI course.Measurements and Main Results We collected LCI from 1204 visits (3603 trials) in 78 participants, of which 907 visits had acceptable LCI data. The average unadjusted increase in LCI for the entire population was 0.29 LCI units·year−1 (95% CI 0.20–0.38). The increase in LCI was more pronounced in adolescence, with 0.41 units·year−1 (95% CI 0.27–0.54). Colonisation with either Pseudomonas aeruginosa or Aspergillus fumigatus, pulmonary exacerbations, CF-related diabetes, and bronchopulmonary aspergillosis were associated with a higher increase in LCI over time. Adjusting for clinical risk factors reduced the increase in LCI over time to 0.24 LCI units·year−1 (95% CI 0.16–0.33).Conclusion LCI measured during routine clinical surveillance is associated with underlying disease progression in children with CF. An increased change in LCI over time should prompt further diagnostic intervention.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Frauchiger has nothing to disclose.Conflict of interest: Dr. Binggeli has nothing to disclose.Conflict of interest: Dr. Yammine reports grants from Swiss National Science Foundation, outside the submitted work.Conflict of interest: Dr. Spycher reports grants from Swiss National Science Foundation, grants from Swiss Cancer League, outside the submitted work.Conflict of interest: Dr. Krüger has nothing to disclose.Conflict of interest: Dr. Ramsey reports grants from Swiss National Science Foundation, outside the submitted work.Conflict of interest: Dr. Latzin reports grants from Vertex, during the conduct of the study; personal fees from Vertex, personal fees from Novartis, personal fees from Roche, personal fees from Polyphor, personal fees from Vifor, personal fees from Gilead, personal fees from Schwabe, personal fees from Zambon, personal fees from Santhera, grants from Vertex, outside the submitted work. %U //www.qdcxjkg.com/content/erj/early/2020/12/10/13993003.02686-2020.full.pdf