TY - JOUR T1 -哮喘和COPD共存:危险因素、临床历史和肺功能轨迹JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.04656 -2020欧元SP - 2004656 AU Marcon亚历山德罗盟——,右路放倒弗朗西斯卡盟——Dharmage Shyamali c . AU - Svanes Cecilie盟——海因里希,约阿希姆盟,研究新兴市场非盟-伯尼,彼得•AU - Corsico安吉洛盟——Caliskan Gulser AU - Calciano,露琪亚盟——Gislason Thorarinn AU -詹森,Christer AU -贾维斯,黛博拉盟-勒夫,雨盟——Lytras西奥多盟——Malinovschi安德烈•AU - Probst-Hensch妮可盟——Toren谢尔AU -卡萨斯,莉迪亚盟——Verlato朱盟——Garcia-Aymerich,朱迪思盟——Accordini西蒙A2 -,合并哮喘和慢性阻塞性肺疾病(COPD)的患者有沉重的疾病负担。利用欧洲共同体呼吸健康调查(European Community Respiratory Health Survey)前瞻性收集的数据，我们比较了从成年早期到60年代晚期患有哮喘+COPD (n=179)、过去(n=263)或目前(n=808)单独哮喘、单独COPD (n=111)的中年受试者的危险因素、临床史和肺功能轨迹。或者这些都没有(n=3477)。方法收集1991-1993年、1999-2002年和2010-2013年三次临床检查的访谈资料和支气管扩张剂前FEV1和FVC。根据是否存在固定气流梗阻(支气管扩张剂后FEV1/FVC低于正常下限)、终生哮喘史、累积烟草或职业吸入剂暴露情况，在2010-2013年对受试者的疾病状况进行分类。对这些表型的肺功能轨迹、临床特征和危险因素进行了估计。主要结果:哮喘+COPD受试者报告母亲吸烟(28.2%)和儿童呼吸道感染(19.1%)的频率高于单独COPD受试者(20.9和14.0%)。 Subjects with asthma+COPD had an impairment of lung function at age 20 that tracked over adulthood, and more than half of them had asthma onset in childhood. Subjects with COPD alone had the highest lifelong exposure to tobacco smoking and occupational inhalants, and they showed accelerated lung function decline during adult life.Conclusions The coexistence between asthma and COPD seems to have its origins earlier in life compared to COPD alone. These findings suggest that prevention of this severe condition, which is typical at older ages, should start in childhood.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Marcon has nothing to disclose.Conflict of interest: Dr. Locatelli has nothing to disclose.Conflict of interest: Dr. Dharmage has nothing to disclose.Conflict of interest: Dr. Svanes has nothing to disclose.Conflict of interest: Dr. Heinrich has nothing to disclose.Conflict of interest: Dr. Leynaert has nothing to disclose.Conflict of interest: Dr. Burney has nothing to disclose.Conflict of interest: Dr. Corsico has nothing to disclose.Conflict of interest: Dr. Caliskan has nothing to disclose.Conflict of interest: Dr. Calciano has nothing to disclose.Conflict of interest: TG has no COI.Conflict of interest: Dr. Janson has nothing to disclose.Conflict of interest: Dr. Jarvis has nothing to disclose.Conflict of interest: Dr. Jõgi reports grants from Estonian Research Council Personal Research Grant no 562, during the conduct of the study; personal fees from Consultancy, grants from Grants/grants pending, personal fees from Payment for lectures, personal fees from Travel/accommodations/meeting expenses, outside the submitted work.Conflict of interest: Dr. Lytras has nothing to disclose.Conflict of interest: Dr. Malinovschi has nothing to disclose.Conflict of interest: Dr. Probst-Hensch has nothing to disclose.Conflict of interest: Dr. Torén has nothing to disclose.Conflict of interest: Dr. Casas has nothing to disclose.Conflict of interest: Dr. Verlato has nothing to disclose.Conflict of interest: Dr. Garcia-Aymerich has nothing to disclose.Conflict of interest: Dr. Accordini has nothing to disclose. ER -