ty -jour t1 -tlr7/8调节I型和III型干扰素信号传导1B诱导的过敏性哮喘JF-欧洲呼吸杂志JO -EUR RESSIR J DO -10.1183/13993003.01562-2020 vl -57- Krug, Jasmin AU - Kiefer, Alexander AU - Koelle, Julia AU - Vuorinen, Tytti AU - Xepapadaki, Paraskevi AU - Stanic, Barbara AU - Chiriac, Mircea T. AU - Akdis, Mübeccel AU - Zimmermann, Theodor AU - Papadopoulos,Nikolaos G. au -Finotto，Susetta Y1-2021/05/01 Ur -http：//www.qdcxjkg.com/content/57/5/5/5/2001562.Abstract N2-介绍了Interferon（IFN）响应已有缺陷。在鼻病毒（RV）诱导的哮喘中。I型IFN（IFN-α/β）的异二聚体受体由IFN-αR1和IFN-αR2组成。配体与IFN-α/β受体复合物的结合激活了信号转导子和转录激活因子（STAT）蛋白STAT1和STAT2细胞内。尽管III型IFN（IFN-λ）与含有IFN-λR1和白介素-10R2的不同受体结合，但其触发会导致激活相同的下游转录因子。在这里，我们分析了RV对IFN I型和III受体的影响，并询问了可能的Toll样受体7/8（TLR7/8）激动剂R848介导的IFN-αR1和IFN-λR1调节。α，IFN-β和IFN-λ及其受体水平在外周血单核细胞（PBMC）上清液和细胞颗粒中用RV1B和R848刺激了两个同类和没有哮喘的儿童，并在学龄前年龄招募和没有哮喘的儿童（预测）和在初中年龄（议程）以及从小鼠分离的总肺细胞的细胞上清液中。我们观察到R848在健康和哮喘儿童的PBMC中诱导了IFN-λRmRNA表达，但抑制了IFN-αRRNAmRNA水平。 In murine lung cells, RV1b alone and together with R848 suppressed IFN-αR protein in T-cells compared with controls and in total lung IFN-λR mRNA compared with RV1b infection alone.Conclusions In PBMCs from pre-school age children, IFN-αR mRNA was reduced and IFN-λR1 mRNA was induced upon treatment with the TLR7/8 agonist R848, thus suggesting new avenues for induction of antiviral immune responses in paediatric asthma.TLR7/8 agonist reduced IFN-αR1 but induced IFN-λR1 in PBMCs of pre-school age children. This induction of IFN-λR1 offers a new mechanism for therapy of children with RV1b-exacerbated asthma. https://bit.ly/2QWnoTp ER -