TY -的T1 - SARS-CoV-2之间的关系RT-PCR cycle threshold and mortality in a community cohort JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00360-2021 SP - 2100360 AU - Waudby-West, Rupert AU - Parcell, Benjamin AU - Palmer, Colin N A AU - Bell, Samira AU - Chalmers, James D AU - Siddiqui, Moneeza K Y1 - 2021/01/01 UR - //www.qdcxjkg.com/content/early/2021/06/10/13993003.00360-2021.abstract N2 - A diagnosis of severe acute respiratory virus coronavirus 2 (SARS-CoV-2) disease is widely made by the use of reverse transcription polymerase chain reaction (RT-PCR). When using RT-PCR, the infectivity of SARS-CoV-2 can be inferred from the threshold cycle (Ct) value [1]. It is best practice to confirm the validity of the standard curve using reference materials or in-house plasmid controls with known viral copy numbers [2]. As the Ct value represents the cycle number at which the signal breaches the threshold for positivity, a lower Ct value is indicative of a higher viral load. Although some studies suggest that viral load is associated with mortality and infectiousness [3, 4], a systematic review has identified little difference in viral load between pre-symptomatic, asymptomatic and symptomatic patients [5].Lower Ct values from RT-PCR tests are associated with higher risk of mortality in SARS-CoV2 infections.Ct values < 20 was associated with 2.20 times the hazards of mortality compared to values >30 [(95%CI: 1.28–3.76) adjusted for age,sex,comorbidities & hopsitalisation ER -