TY - T1的结核病诊断的准确性凳子爱视宝MTB / RIF和尿液AlereLAM弱势儿童JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01116 -2021欧元六世- 59 - 1 SP - 2101116 AU -帕特里克Orikiriza AU -史密斯朱丽安娜AU -鲍勃Ssekyanzi AU -丹Nyehangane AU -伊万·穆吉沙Taremwa AU -以斯帖Turyashemererwa盟Onesmas Byamukama盟Tobias Tusabe AU - Elisa Ardizzoni盟本·J·Marais说非盟-埃里克Wobudeya盟-伊丽莎白Kemigisha盟朱丽叶Mwanga-Amumpaire AU -多拉Nampijja盟Maryline帽子Y1 - 2022/01/01 UR - //www.qdcxjkg.com/content/59/1/2101116.abstract N2 -背景Non-sputum-based诊断方法是至关重要的高危儿童中传播肺结核(TB)不能咳出痰痰。我们评估结核分枝杆菌凳子爱视宝的诊断准确性/ RIF和尿液AlereLAM测试在这群孩子。方法住院儿童的结核病和年龄& lt; 2年,艾滋病毒阳性或加入一个诊断严重营养不良。在招生,我们试图收集两个尿,两个凳子和两个呼吸样本。尿液和粪便进行了AlereLAM和爱视宝MTB / RIF,分别。结核分枝杆菌呼吸道样本测试爱视宝/ RIF和分枝杆菌培养。微生物和复合临床参考标准。结果研究分析了219名儿童;平均年龄16.4个月,72例(32.9%)阳性,184(84.4%)严重营养不良。12(5.5%)和58例(28.5%)孩子已经确认和未经证实的结核,分别。粪便和尿液收集在219年(100%)和216年(98.6%)的孩子,分别。 Against the microbiological reference standard, the sensitivity and specificity of stool Xpert MTB/RIF was 50.0% (6/12, 95% CI 21.1–78.9%) and 99.1% (198/200, 95% 96.4–99.9%), while that of urine AlereLAM was 50.0% (6/12, 95% 21.1–78.9%) and 74.6% (147/197, 95% 67.9–80.5%), respectively. Against the composite reference standard, sensitivity was reduced to 11.4% (8/70) for stool and 26.2% (17/68) for urine, with no major difference by age group (<2 and ≥2 years) or HIV status.Conclusions The Xpert MTB/RIF assay has excellent specificity on stool, but sensitivity is suboptimal. Urine AlereLAM is compromised by poor sensitivity and specificity in children.Modest sensitivity but high specificity and good feasibility support the use of stool Xpert MTB/RIF in young children at high risk of disseminated tuberculosis; however, urine AlereLAM showed poor specificity and has little applicability https://bit.ly/3oMLNHUThis work was made possible through several contributions of staff and partners at different levels. We would like to particularly express our gratitude to the study participants. We also thank the nurses, laboratory and data personnel of Epicentre Mbarara Research Centre (Mbarara, Uganda) that participated in data collection and analysis. Special credit goes to Médecins Sans Frontières for the funding. ER -