细胞支气管肺泡灌洗液剖面是否反映结节病的严重程度?JF -欧洲呼吸杂志JO - Eur Respiratory J SP - 1338 LP - 1344 VL - 13 IS - 6 AU - Drent, M AU - Jacobs, JA AU - de Vries, J AU - Lamers, RJ AU - Liem, IH AU - Wouters，EF Y1 - 1999/06/01 UR - //www.qdcxjkg.com/content/13/6/1338.abstract N2 -本研究的目的是评估细胞是否支气管肺泡灌洗液(BALF)剖面,特别是多形核中性粒细胞(中性粒细胞)的数量,与疾病的严重程度决定缓解结节病及其实用性。本研究共纳入二十六个非吸烟门诊结节病患者。根据BALF中pmn的绝对数量将患者分为2个亚组:<or =0.2x10(4) cells x mL(-1)(组1;n = 15)和>0.2x10(4)细胞x mL(-1)(2组;n = 11)。第1组和第2组的影像学分期、高分辨率ct (HRCT)表现、67Ga肺摄取及肺功能检查差异显著。随访显示，组1有14例(93.3%)患者在未使用皮质激素的情况下自行康复，而组2有4例(36.4%)患者自行康复。 In contrast, no differences were found in the number of lymphocytes in BALF nor in the serum angiotensin converting enzyme (sACE) level between both groups. The number of PMNs, the transfer factor of the lungs for carbon monoxide (TL,CO), the forced expiratory volume in one second (FEV1) and one of the HRCT subscores discriminated between patients with different disease progression. Of these parameters the PMNs appeared to be the only one which differentiated patients who demonstrated remission and those who deteriorated. In conclusion, these results indicate that the number of polymorphonuclear neutrophils in bronchoalveolar lavage fluid distinguish between sarcoidosis patients who demonstrated remission and those having a more severe course of the disease. Whether polymorphonuclear neutrophils may be considered as markers of disease activity and/or prognosis in sarcoidosis needs further investigation. ER -