TY-JUR T1 - Sjogren综合征患者的过期空气中的一氧化氮增加。BHR研究组。支气管高反应效率JF - 欧洲呼吸期刊Jo - Eur Respir J SP - 739 LP - 743 VL - 13是 - 4 Au - Ludviksdottir，D Au - Janson，C Au - Hogman，M Au - Gudbornsson，B Au - Bjornsson，E Au- Valtysdottir，S Au - Hedenstrom，H Au - Venge，P Au - Boman，G Y1 - 1999/04/01 UR - //www.qdcxjkg.com/content/13/4/739.abstract n2 - 硝化氧化物在气道功能的调节中具有重要作用，并且可以具有促炎作用。支气管高反应性（BHR）和呼吸系统症状是Sjogren综合征（SS）的患者常见的。本研究的目的是确定SS的患者是否具有增加的呼出量，也没有与呼吸系统症状和BHR相关。在18例SS和13名正常受试者中测量呼出的NO，在三种不同的场合使用化学发光方法的间隔至少3天。通过甲胆碱挑衅评估气道反应性。测定血清髓过氧化物酶（MPO），人嗜嗜中性粒细胞脂素（HNL），嗜酸性粒细胞阳离子蛋白（ECP）和嗜酸性粒细胞过氧化物酶（EPO）。 Exhaled NO was significantly higher in patients with SS than in controls (147+/-82 versus 88+/-52 nL x min(-1); mean+/-SD; p=0.041). Exhaled NO was correlated with age (partial r=0.52, p=0.006) and serum HNL (partial r=0.46, p=0.014). There were no significant correlations between exhaled NO and respiratory symptoms, BHR or serum MPO, ECP or EPO. Disease duration was negatively associated with serum MPO (r=-0.47, p=0.043). In patients with SS, a positive correlation was found between symptom score and serum ECP (partial r=0.65, p=0.003) and EPO (partial r=0.62, p=0.004) and a negative correlation with age (partial r=-0.60, p=0.005). In conclusion, elevated levels of exhaled nitric oxide in patients with Sjogren's syndrome were demonstrated. The mechanism underlying this increase in exhaled nitric oxide in Sjogren's syndrome is not known. ER -