TY -的T1 -支气管高反应性和成人发作喘息:特异反应性的影响摩根富林明-欧洲呼吸杂志》乔和J SP - 335 LP - 338欧元六世- 14 - 2非盟。博得纳,C盟——Godden D AU -罗斯,年代盟——小J AU -道格拉斯,詹盟——Legge J盟,Seaton盟——朋友,J Y1 - 1999/08/01 UR - //www.qdcxjkg.com/content/14/2/335.abstract N2 -普遍认为成人气喘病发作主要是nonatopic本质上表明,特异反应性的作用的病理生理学支气管高反应性(BHR)在成人喘息发作可能是最小的。This study examined risk factors for BHR (BHR: provocative dose causing a 20% fall in forced expiratory volume in one second PD20 < or =16.38 micromol methacholine) among 82 subjects with adult onset wheeze and among 191 subjects who had never wheezed. Subjects were identified from a cohort of subjects aged 39-45 yrs who were known to have had no childhood wheeze and who were involved in a 30 yr follow-up survey. Risk factors for BHR were examined among all subjects with BHR and among subjects with BHR stratified according to whether or not they had ever wheezed. The prevalence of BHR was 40% (33/82) among the subjects with adult onset wheeze and 11% (21/191) among the subjects who had never wheezed. Lower baseline lung function (odds ratio (OR) = 0.94; 95% confidence interval (CI) = 0.92-0.97 per unit forced expiratory volume (FEV1)% predicted) and atopy (OR = 7.23; CI = 2.53-20.64 for all three measures of atopic compared to nonatopic) were associated with BHR, while smoking and family history showed no statistically significant relation to BHR. This pattern was also apparent in analyses stratified by symptom status. A family history of atopy increased the risk that BHR was accompanied by wheezing symptoms (OR = 4.75; CI = 1.53-14.72 for more than one affected relative compared to no affected relatives). These findings suggest that atopy is associated with bronchial hyperresponsiveness in adults known to have had no childhood wheeze. A familial factor reflecting genetic influences and/or shared environmental factors may influence whether bronchial hyperresponsiveness is associated with symptoms. ER -