%0期刊论文%A须贺,M%甲Iyonaga,K%A Ichiyasu,H%A SAITA,N%A山崎,H%A安藤,患者在BALF MCP-1水平的M个%T临床意义和血清间质性肺病%d%1999年Ĵ欧洲呼吸杂志%P 376-382%V 14%N 2%X之前已经报道了单核细胞趋化蛋白-1(MCP-1)的患者的肺组织中的表达特发性肺纤维化(IPF)是在患有其他间质性肺疾病(的ILD)的组织中的不同。本研究的目的是确定该差是否反映MCP-1在支气管肺泡灌洗液(BALF)或患者的血清ILD的量,以及是否这样的相关性,如果它存在,在临床上是有用的。MCP-1的浓度在BALF和血清在86名患者进行了评价用的ILD包括IPF,急性间质性肺炎,间质性肺炎与胶原血管病(IP-CVD),慢性间质性肺炎(CIP),闭塞性细支气管炎机化性肺炎,结节病,过敏性肺炎,并在10名正常健康志愿者谁是控制(NC)。BALF MCP-1水平在IPF,IP-CVD,CIP和结节病组分别显著升高与NC组进行比较。在IPF组中的水平明显高于在任何其他患者组显著高。血清MCP-1在IPF,IP-CVD水平,CIP和结节病组比NC组显著高。无统​​计学差异在IPF,IP-CVD和CIP组之间血清MCP-1水平找到。 BALF MCP-1 levels were significantly higher than serum MCP-1 levels in the IPF group and lower than in the IP-CVD and CIP groups. Serum MCP-1 levels correlated with the clinical course of ILD treated with corticosteroid therapy. These results show that measurement of monocyte chemoattractant protein-1 levels in both bronchoalveolar lavage fluid and serum may be helpful in discriminating idiopathic pulmonary fibrosis from other types of interstitial lung disease and that monitoring of serum monocyte chemoattractant protein-1 may be useful for predicting the clinical course of interstitial lung diseases. %U //www.qdcxjkg.com/content/erj/14/2/376.full.pdf