TY - JOUR T1 -儿童哮喘:呼出一氧化氮与临床症状JF -欧洲呼吸杂志》乔和J SP - 1396 LP - 1401欧元六世- 13 - 6盟Artlich,非盟——布施,T非盟- Lewandowski, K AU -乔纳斯,年代盟——Gortner L盟——FalkeN2 -支气管哮喘与呼出的一氧化氮水平升高有关，吸入糖皮质激素可抑制一氧化氮。研究支气管哮喘患儿内源性NO释放与近期支气管梗阻症状的关系。研究对象为25名特应性哮喘患儿和11名健康对照者，采用化学发光分析法对呼出NO进行研究。受试者只通过嘴呼吸净化空气(十亿分之0.5 NO)。在连续滴鼻(1.3 L x min(-1))过程中测量口服过期NO，以去除鼻腔产生的NO。测定吸入气体中鼻NO的浓度。健康对照组口服过期NO浓度为2.5+/-0.3 ppb(平均值+/-SEM)，无症状儿童口服过期NO浓度为3.19+/-0.88 ppb (NS)，无症状儿童口服过期NO浓度为8.28+/-0.81 ppb (p;或=0.01)，近期有支气管梗阻症状的支气管哮喘儿童。 Similarly, in the subgroup of children treated regularly with inhaled glucocorticosteroids those with recent symptoms had significantly higher orally exhaled NO concentrations than healthy control subjects (9.5+/-1.5 ppb, p<0.05). The nasal NO concentration was 152.8+/-12.7 ppb in healthy control subjects and not significantly different in asthmatic children. In this group of asthmatic children, recent symptoms of bronchial obstruction were linked to significantly higher concentrations of NO in orally exhaled gas and to increased oral NO excretion rates. If substantiated by further studies, measurement of orally exhaled NO during nasal aspiration may become useful to monitor disease control in asthmatic children. ER -