RT Journal第SR电子T1儿童哮喘:呼出一氧化氮与临床症状JF欧洲呼吸期刊Jo EUR Respir J FD欧洲呼吸学会SP 1396 OP 1401 VO 13是6 A1 Artlich,A A1 Busch,T A1 Lewandowski,K A1188bet官网地址Jonas,S A1 Gortner,L A1 Falke,KJ YR 1999 UL //www.qdcxjkg.com/content/13/6/1396.abstract/13/6/1396.abstract Ab支气管哮喘与氧化术类固醇抑制的呼出式一氧化物的增加有关吸入。研究了带支气管哮喘的儿童,以阐明内源性无释放与支气管梗阻最近症状之间的关系。注册了25名具有特应性哮喘和11个健康对照受试者的儿童,使用化学发光分析研究了呼出NO。受试者专门呼吸净化的空气(<0.5零件(PPB)NO)。在连续鼻腔抽吸期间测量口服过期的否(1.3 L x min(-1))以除去鼻子产生的NO。鼻腔没有浓度在吸气气体中确定。口服过期不浓度为2.5 +/- 0.3 ppb(平均+/- em),在健康对策中,无症状儿童3.19 +/- 0.88 ppb(ns),8.28 +/- 0.81 ppb(p <或=0.01)在带支气管哮喘的儿童患有最近的支气管梗阻的症状。类似地,在具有吸入的糖皮质激素的儿童的儿童亚组中,近期症状的症状显着更高口头呼出,没有浓度的浓度高于健康的对策(9.5 +/- 1.5 ppb,P <0.05)。 The nasal NO concentration was 152.8+/-12.7 ppb in healthy control subjects and not significantly different in asthmatic children. In this group of asthmatic children, recent symptoms of bronchial obstruction were linked to significantly higher concentrations of NO in orally exhaled gas and to increased oral NO excretion rates. If substantiated by further studies, measurement of orally exhaled NO during nasal aspiration may become useful to monitor disease control in asthmatic children.