PT -期刊文章盟Vos PJ AU -福杰尔,HT AU -嘘,TM盟——Lemmens WJ AU - van Herwaarden CL TI -醋酸氯地孕酮、乙酰唑胺和氧气体交换睡眠和觉醒在慢性阻塞性肺病(COPD)患者DP - 1994年5月01 TA -欧洲呼吸杂志》第六PG - 850 - 855 - 7 IP - 5 4099 - //www.qdcxjkg.com/content/7/5/850.short 4100 - //www.qdcxjkg.com/content/7/5/850.full所以欧元和J1994可能01;7 AB -本研究的目的是评估的短期影响醋酸氯地孕酮(CMA),一个合成的孕激素,乙酰唑胺(乙炔)和氧气在睡眠和觉醒血气值。这项研究是根据进行随机、双盲和安慰剂对照设计在53个hypoxaemic慢性阻塞性肺疾病患者。在第一次连续两个晚上,所有患者接受室内空气或氧气,通过鼻插管,以随机的顺序。然后他们分别接受了CMA(25毫克),乙炔(250毫克)或安慰剂,一天两次,在相同的胶囊。在第三个研究晚上,经过一个星期的药物治疗,患者呼吸室内空气进行测试。CMA和乙炔治疗动脉二氧化碳张力降低意味着白天(PaCO2) 0.7和0.5 kPa,分别和夜间end-tidal二氧化碳张力(PETCO2) 0.5和0.3 kPa,分别。补充氧气的增加导致了二氧化碳潴留在日夜(分别为0.6和0.3 kPa。白天动脉氧张力(PaO2)增加到相同的程度上在乙炔(1.9 kPa)和氧(2.5 kPa)。睡着了与氧氧饱和度改善大多数补充(7%),尽管乙炔也引起显著改善(4%)。 CMA administration had virtually no effect on mean awake and asleep hypoxaemia. ACET therapy significantly improved subjective sleep quality. On CMA, minute ventilation increased in association with an augmentation of the hypercapnic ventilatory response. ACET treatment increased both hypercapnic and hypoxic ventilatory responses. We conclude from the group of patients with COPD studied, that the short-term effects of ACET treatment on gas exchange compare favourably with those of CMA. Oxygen therapy improves oxygenation slightly more than ACET, but aggravates CO2 retention.