TY - JOUR T1 -铝加工车间工人的支气管反应性和FEV1下降JF -欧洲呼吸杂志JO - Eur Respir J SP - 888 LP - 894 DO - 10.1183/09031936.94.07050888 VL - 7 IS - 5 AU - Soyseth, V AU - Kongerud, J AU - Kjuus, H AU - Boe，J Y1 - 1994/05/01 UR - //www.qdcxjkg.com/content/7/5/888.abstract N2 -我们研究了铝室工人一秒内用力呼气量(delta FEV1)的年下降与支气管反应性(BR)之间的关系。在一项为期6年的肺功能随访研究中，337名铝加工厂工人的横断面研究测量了BR。还进行了皮肤点刺试验(SPT)。随访期间，每位受试者肺功能(FEV1)的平均测量次数为6.8次。平均delta FEV1为21.3 ml.yr-1(受试者SD = 30.5 ml.yr-1)。在具有刺激性浓度的受试者中，FEV1 (PC20)下降20%，平均delta FEV1为57.0,44.5和16.6 ml.yr-1;Or = 8.0, 8.1-32.0 and >32.0毫克。分别ml-1。 After adjustment for gender, atopy, smoking habit, FEV1, age and familial asthma the association between BR and delta FEV1 was weakened, and was not statistically significant. A significantly accelerated decline in FEV1 with age was found. The difference in delta FEV1 between smokers and nonsmokers was 39.3 ml.yr-1, and between subjects who had a positive skin-prick test compared to subjects with a negative skin-prick test 39.6 ml.yr-1. In subjects reporting work-related asthmatic symptoms the decline in FEV1 was 43.2 ml.yr-1 greater than in asymptomatic subjects. In asymptomatic subjects, positive skin-prick test was also associated with increased delta FEV1. These data indicate that a single measurement of BR is not a predictor of delta FEV1 in aluminium potroom workers. Smoking, work-related asthmatic symptoms, and positive reaction to skin-prick test in asymptomatic workers were risk factors of increased delta FEV1. ER -